Recovery Tracker
How We Compiled Our Data. Visit our Eye on the Stimulus blog. Data current as of Sept. 30, 2009 (the latest available data as of Dec. 2009).
Erie County
Funding Breakdown
| U.S. | New York | Erie | ||
|---|---|---|---|---|
| Population | 304,059,724 | 19,490,297 | 909,845 | |
| Total recovery funding | $260,908,876,834 | $19,782,147,945 | $270,794,235 | |
| Direct to County | $188,787,799,322 | $12,004,816,573 | $270,794,235 | |
| County Funds per Capita | $621 | $616 | $298 | |
| Unemployment (10/09) |
10.2 | 9.0 | 8.2 | |
| Median Household Income | $50,007 | $52,944 | $44,650 | |
| Poverty Rate | 13.3% | 14.0% | 13.9% |
Stimulus contracts, grants and loans as of Dec. 7, 2009.
County Projects
Stimulus contracts, grants and loans in Erie County, New York. Data last updated on Sept. 30, 2009 (the latest available data as of Dec. 2009).
Note: There still may be overrepresentation of money going to counties where state capitals are because of funding going to state agencies but where the data did not designate that it was to be used statewide.
Amount refers to both the amount of stimulus funding going toward the project and the face value of the loan.
| Recipient | Amount | Type | Description | Agency | Date |
|---|---|---|---|---|---|
| BUFFALO PHILHARMONIC ORCHESTRA SOCIETY, INC. | $50,000.00 | Grant | Awards to Organizations and Individuals To support the preservation of jobs that are threa | National Endowment for the Arts | 7/15/2009 |
| CENTER FOR EXPLORATORY & PERCEPTUAL ART INC | $25,000.00 | Grant | Awards to Organizations and Individuals To support the preservation of jobs that are threa | National Endowment for the Arts | 7/01/2009 |
| JUST BUFFALO LITERARY CENTER INC | $25,000.00 | Grant | Awards to Organizations and Individuals To support the preservation of jobs that are threa | National Endowment for the Arts | 7/06/2009 |
| D'YOUVILLE COLLEGE | $49,294.00 | Grant | ARRA - Scholarships for Disadvantaged Students Scholarships for disadvantaged undergraduate nursi | Health Resources and Services Administration | 9/01/2009 |
| HEALTH RESEARCH, INC. | $335,208.00 | Grant | Trans-NIH Recovery Act Research Support Summary description of the project that matches the Award: Our data indicate that the human prostate-derived Ets transcription factor (PDEF) plays an essential role in tumor suppression via downregulation of the expression of antiapoptotic protein survivin. Ectopic expression of PDEF in PDEF-negative breast cancer cells inhibits survivin expression as well as its promoter activity. In contrast, knockdown of PDEF in PDEF-positive breast cancer cells upregulates survivin expression along with increased cell proliferation in vitro, and increases xenograft tumor take rate and tumor growth in vivo. Importantly, patients with survivin-/PDEF+ tumor show better survival and less relapse than patients with survivin+/PDEF- tumor. Abnormal inhibition of apoptosis is known to be one of the critical steps for oncogenesis and malignant progression. Although the underlying mechanisms are not fully understood, evidence indicates that survivin plays an important role in the initiation, progression, metastasis and recurrence of cancer. Accordingly, many natural dietary components, including resveratrol, silibinin, sulindac, retinoid, selenium and vitamin D compounds that have cancer-preventive and therapeutic effects, downregulate survivin expression. PDEF appears to have an opposing role to survivin and likely via downregulation of survivin expression. It has been shown that PDEF inhibits cancer cell migration, invasion and growth. Based on these observations, we hypothesize that application of survivin and PDEF as interconnected biomarkers and targets to stratify patents with survivin+/PDEF- tumor and patients with survivin-/PDEF+ tumor may facilitate prostate cancer prognosis and personalized medicine. Two specific aims are proposed to test this hypothesis. In Aim 1, we will use a large cohort of prostate cancer tissues to determine survivin and PDEF expression status. Then we will analyze the association of survivin and PDEF expression status with patient survival, cancer metastasis and tumor relapse by appropriate statistical methods. In Aim 2, we will determine the methylation status in the PDEF gene in prostate cancer tissues. Then we will analyze the association of PDEF methylation status with the expression of PDEF and survivin. These studies may provide novel approaches for cancer prognosis and personalized medicine, by stratifying patients with survivin+/PDEF- tumor and patients with survivin-/PDEF+ tumor. Show more... | National Institutes of Health | 6/05/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $410,442.00 | Grant | Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area (01) Behavior, Behavioral Change, and Prevention and specific Challenge Topic, 01-GM-104: Mechanisms of Behavior Change Research. Cognitive-behavioral therapy (CBT) is well-established as an effective treatment for alcohol dependence. However, many of the pretreatment-posttreatment designs used to study CBT, while important in answering questions about if a treatment works, provide much less information about how CBT works. In recent years, there has been a resurgence of interest in studying what happens between the pretreatment and posttreatment assessment- the process of change-and a renewed understanding of the important role of this research in treatment development (Hayes, Hope, & Hayes, 2007). A central mechanism of CBT is the acquisition and use of coping skills. However, in a review of 10 studies that tested coping as a hypothesized mechanism of action of CBT, Morganstern and Longabuagh (2000) concluded that there is no support for the hypothesis that CBT works through its effects on coping. Although several possible mechanisms have been proposed to explain the effects of CBT, it is rare that more than one mechanism is studied. According to Kazdin (2007), the assessment of multiple mediators (viz. mechanisms) in a given study has enormous benefits. If two or more mechanisms are studied, one can identify if one is more plausible or makes a greater contribution to the outcome. In addition, the assessment of multiple potential mechanisms is cost efficient, given the amount of time and resources needed for any one treatment outcome study. Across many studies, some mechanisms may repeatedly emerge as possible contenders while others fall by the wayside. In addition to coping skills, two key mechanisms posited to underlie the effectiveness of CBT are increasing self-efficacy and self- confidence and reducing positive outcome expectancies for alcohol use (Moos, 2007). Two other mechanisms, thought to be operating across many different interventions, including CBT, are increasing the therapeutic alliance and reducing/regulating negative emotional states. For the present study, participants will be 72 alcohol dependent men and women who agree to participate in a 12-week trial of CBT for alcohol dependence. In addition, comprehensive research assessments will be conducted with patients at baseline, end of treatment, and 3-months posttreatment. The overarching goal of the present study is to map the process of change in successful CBT by measuring the aforementioned 4 theoretically relevant behavioral mechanisms of change on multiple (i.e., weekly) occasions during treatment. As Hayes et al. (2007) state, such a 'map' would have several important implications, including, (1) further refinement of existing treatment procedures; (2) a clearer picture of the processes of recovery, treatment dropout, poor response, and relapse; and (3) further development of empirically supported treatment processes. Although several possible mechanisms have been proposed to explain the effects of CBT, it is rare that more than one mechanism is studied. The goal of the present study is to map the process of change in successful CBT by measuring 4 theoretically relevant behavioral mechanisms of change on multiple occasions during treatment (i.e., following weekly treatment sessions). Such a fine-grained analysis is needed in order to study the unfolding of processes over time. Such a 'map' would have several important implications, including, (1) further refinement of existing treatment procedures; (2) a clearer picture of the processes of recovery, treatment dropout, poor response, and relapse; and (3) further development of empirically supported treatment processes. Show more... | National Institutes of Health | 9/28/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $385,377.00 | Grant | Trans-NIH Recovery Act Research Support This application proposes to develop two novel prophylactic and therapeutic non-viral gene transfer strategies that target pulmonary cells in vivo employing nanotechnology. The lung is especially well suited for these treatment strategies as direct contact with the environment provides a portal for inhalation administration of cDNA and siRNA conjugated nanoplexes. The emergence of drug-resistant strains of human influenza A and B viruses, as well as avian H5N1 influenza viruses with pandemic potential to one or both classes of approved antiviral agents underscores the importance of developing novel antiviral strategies. The primary objective of the R21 phase is to construct an electrostatic complex between a cationic nanoparticle (i.e., Gold Nanorods, GNR) and anionic genetic material (i.e., cDNA or siRNA). These nanoplexes will be engineered such that they can be taken-up and express bioactivity in large airway (i.e., bronchial) epithelial cells with little or no untoward cellular or pulmonary responses. The siRNA/cDNA constructs, which have just recently been synthesized, have dual actions of suppressing the translation of the influenza virulence factor, NS1, as well as independently stimulating type I interferon production through activation of the RIG-I pathway. Stimulation of this antiviral innate immune pathway occurs as a result of a triphosphate (PPP) moiety attached to the 5' end of the siRNA. We will preferentially administer the GNR-5'PPP-NS1siRNA or its counterpart cDNA nanoplexes to the tracheal and bronchial epithelium in vivo, thereby increasing the safety of the treatment. Extension of these nanotechnological approaches can also be applied to treat other infectious, as well as non-infectious acute lung injuries. The focus in the R33 phase will be to demonstrate the therapeutic efficacy of using 5'PPP-NS1siRNA and cDNA-nanoplex targeting of large airway epithelial cells in vivo before and during influenza. In addition to assessing the clearance of influenza virus from the respiratory tract, the R33 phase will specifically examine the ability of 5'PPP-NS1siRNA or cDNA-nanoplexes to stimulate innate antiviral immunity, resulting in alteration of the inflammatory cytokine milieu, adaptive immune response, and antibacterial host defense, as well as prevent or reduce the degree of viral induced respiratory injury and impairment of bacterial clearance. We predict that these large airway epithelial-targeted nanoplexes will lead to prophylactic and therapeutic options that can prevent or significantly reduce the morbidity and severity of symptoms of influenza including the highly pathogenic H5N1 'bird flu' and the risk of secondary bacterial pneumonia, which is the major cause of death secondary to influenza. It is our goal to have a nanoparticle mediated novel antiviral prophylactic and therapeutic strategy at the completion of the R33 phase available for Investigational New Drug filing with the FDA to go for Phase 1 clinical trials as a result of the experiments proposed in this application. Show more... | National Institutes of Health | 7/22/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $191,544.00 | Grant | Trans-NIH Recovery Act Research Support Chronic renal allograft survival is poorer in African Americans than Caucasians which may be due to medication non-adherence, racial differences in immunosuppressive pharmacokinetics, genomic factors, increased immunoreactivity, and racial variation in immunodynamic responses. This proposal describes a pilot study that is based on our preliminary findings that indicate race and gender impact on the interpatient variability in drug transport (gene and protein) and immunodynamic responses with immunosuppressive drug exposure within a dosing interval after renal transplantation. The hypothesis of this application is that individual renal allograft recipients receiving chronic, dose-adjusted immunosuppressives exhibit a time-dependent drug transporter dynamics and immunologic responses over a dosing interval that are influenced by race and gender. The specific aims are to: 1) Examine race and gender influence on time-dependent extracellular/intracellular immunodynamic responses and their relationship to extracellular/intracellular immunosuppressive concentrations; 2) Investigate interpatient and intrapatient, time-dependent patterns of P- glycoprotein expression (gene and protein) and function in relation to race, gender and drug concentrations. These aims will extend our initial four-hour studies of time-dependent responses of MDR1 gene expression, intracellular cytokines (IL-2 and IL-4) and extracellular immunodynamic responses of CD4+ and CD8+ T regulatory cells, T Helper 1 and T Helper 2 lymphocytes to include an entire twelve-hour dosing interval in renal transplant recipients. This study will also investigate the relationship of the P-gp transport protein and immunodynamic responses to race, gender, age, drug exposure, renal function, time post-transplant, HLA compatibility and concurrent medications. The results of this study will provide preliminary data to create a bridge from the non-specific clinical monitoring methods that are currently used to create a novel approach that incorporates cellular and genomic biomarkers. This patient specific approach will allow clinicians to provide more individualized immunosuppressive therapy and enhance allograft survival. PUBLIC HEALTH RELEVANCE: The significance of this project is related to the growing need for strategies that will increase allograft survival and function following renal transplantation due to the rising incidence of end stage renal disease in the United States. A primary concern is the observed racial disparity with regard to suboptimal renal allograft outcomes in spite of improved drug therapy. The results of this study will lead to the development of new therapeutic guidelines as well as potential biomarkers that incorporate race and gender differences in response to immunosuppression and facilitate individualization of drug treatment and improved allograft survival and function. Show more... | National Institutes of Health | 6/23/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $389,985.00 | Grant | Trans-NIH Recovery Act Research Support Major developments in molecular biology, coupled with strides in genomics and proteomics, have led to an explosive growth in biological data. To obtain usable, relevant information from these vast databases (e.g. through data mining) it is mandatory to use advanced computational methods and hardware. The rapidly expanding field of bioinformatics, where biology, computer science, and information technology merge to form a single discipline, has the potential to serve as a bridge between medical informatics and experimental science. In this proposal we focus on a unique cohort of HIV-1 infected subjects, long term non-progressors (LTNP), who can remain asymptomatic for >15 yr without antiretroviral therapy. Many factors underlie the LTNP state. This project, which expands our current bioinformatics studies in a more translational direction, will develop a complex clinical and experimental database that will be analyzed by powerful informatics tools to identify key genes and proteins that contribute to the LTNP phenotype. We hypothesize that using innovative informatics technology that we specifically develop, we shall prepare a publicly available, large, interactive database containing medical, genomic and proteomic information on HIV-1 infected patients that can be queried to guide rational, evidence-based, decision making at both the clinical and public health levels. Our proposal represents a productive partnership between 3 specialized research groups, with extensive expertise in: a) clinical management of HIV-1 disease, b) molecular and cellular immunovirology, and c) bioinformatics and computational sciences. The goal of this biomedical informatics proposal is the characterization and efficient utilization of data obtained from basic biomedical research and integrate it with clinical outcome. The following specific aims are proposed. Specific Aim 1: To identify functional genes and proteins that are unique to our specific HIV-1 infected patient cohorts using state of the art genomic and proteomic technologies. Specific Aim 2: To evaluate the role of human allelic variants in influencing the rate of HIV-1 disease progression using SNP analysis and real time, quantitative PCR. Specific Aim 3: To develop new computational tools to analyze and integrate genomic, proteomic, and clinical data from our HIV-1 patient cohorts and convert them into clinically useful information relating to the pathogenesis, transmission and therapeutic response of HIV-1 infected patients. This will involve the design of: data mining-oriented schemas; advanced algorithms for integrating genomic, proteomic, and clinical data in a data warehouse; and metrics and methods to explore the association between host genetic variations and HIV disease. Ultimately this database will be provided on the web as a publicly accessible resource. This study will contribute to our fundamental understanding of the pathogenesis of HIV infections and identify new biomarkers of disease progression and potential molecular targets for therapy. Show more... | National Institutes of Health | 7/22/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $250,000.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 3 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 5/26/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $230,937.00 | Grant | Trans-NIH Recovery Act Research Support Communication in Late-stage Cancer: Exploring Hospice Decisions This application addresses broad Challenge Area (04): Clinical Research and specific Challenge Topic, 04-NR-103*: Methods to Enhance Palliative Care and End-of-Life Research. Estimates indicate that 388,322 people over age 65 died from cancer in 2005 and that almost 60% of all newly diagnosed malignant tumors and 70% of all cancer deaths occur in this age group.2,9 People who are age 65 or older are 10 times more likely to be diagnosed with cancer and 15 times likely to die from it than are people under age 65.10 Cancer of the pancreas, stomach, rectum, lung, leukemia, non-Hodgkin's lymphoma, liver, kidney, and ovarian cancers account for two-thirds to three-quarters of cancer deaths in older adults.10 Each cancer trajectory is unique and distinct, being influenced by numerous factors which include: the type of cancer, its lethality and stage at diagnosis, the available treatment and its side effects, all coexisting comorbid conditions, the person's age, and the nature of communication with providers and family members.11 Each type of cancer is accompanied by different symptom clusters which shape and influence the lived experience of cancer and are likely to inform communication and decision-making about the utilization of services such as home care and hospice. While 44% of all hospice patients have cancer and four out of five are over age 65, many older cancer patients only utilize hospice for short periods of time or decline it altogether. The overall purpose of this study is to explore and describe how, when and with whom, older cancer patients communicate their concerns and needs for care during the advanced stages of the illness and compare the decision-making and service utilization of cancer patients who have enrolled in hospice with those who have not. Specifically the study aims to: 1. Explore the factors that contribute to older cancer patients' decisions about service utilization and the timing of their decisions; 2. Compare decision-making and service utilization patterns of older cancer patients who are enrolled in hospice with those who are not 3. Determine how decision-making about service utilization is different relative to the type of cancer and its trajectory; 4. Explore family caregivers' roles in decision-making. This exploratory descriptive study will employ a sequential mixed methods design involving multiple types of data which will be linked for the purpose of developing complementarity between the overlapping perspectives of cancer patients and their caregivers. Data will be collected through in-depth interviews which will include a combination of open-ended and categorical questions as well as standardized measures.34 The rationale for using mixed qualitative and quantitative data is to generate a deeper understanding of the complexities of hospice decision making. The results will provide information about clinical decisions in 'real time' by gathering the experiences of cancer patients and their families in their own words. Guided by a 7 stage framework of decision-making32, participants will be asked about how and when they chose the services they are using. The resulting descriptive profile will contribute to a deeper understanding of how older people talk about and decide to seek care during in advanced cancer. The results of this study are relevant to public health in three ways. (1) Understanding how older people comprehend, perceive and experience advanced cancer and the availability of services at life's end has direct relevance to quality of life in advanced cancer. (2) Exploring decision-making about hospice enrollment or declination and the timing of that decision will inform healthcare providers about communication with older cancer patients and their families. ?The complete abstract for this award is available at http://report.nih.gov/recovery/ Show more... | National Institutes of Health | 9/23/2009 |
| HEALTH RESEARCH, INC. | $297,488.00 | Grant | Trans-NIH Recovery Act Research Support Asthma is a disease of chronic inflammation marked by periodic bouts of acute exacerbations of airway obstruction, and early sub-clinical eosinophilic pulmonary inflammation precedes the development of asthma in children. Why certain individuals develop asthma and factors contributing to the severity of acute exacerbations remain poorly understood. The ST6Gal-1 sialyltransferase constructs the sialyl ?Ñ2,6 to Gal?Ò1,4GlcNAc glycan structures. Our preliminary data point to a previously unrecognized role of ST6Gal-1 in modulating experimental allergic airway inflammation. Mutant mice with ST6Gal-1 deficiencies have exaggerated acute allergic airway inflammation. Expression of recombinant ST6Gal-1 in vivo can attenuate the pulmonary eosinophilia, suggesting a therapeutic potential for ST6Gal-1. Following induction of experimental allergic airway inflammation, wild-type mice with normal ST6Gal-1 expression profiles had significantly depressed circulatory ST6Gal-1 levels. Therefore, natural circulatory ST6Gal-1 levels and serum sialylation products may have potential in identifying persons at risk for allergic airway disease and as a marker for disease severity. This is an exploratory proposal to test the hypothesis that ST6Gal-1 can regulate allergic respiratory inflammation and to evaluate ST6Gal-1 as a marker for asthma disease severity and as a therapeutic target. Specifically, we propose to 1) determine the extent that pulmonary inflammation and asthma-like pathologies are affected in mutant mice with deficiencies in ST6Gal-1; 2) determine the extent that pulmonary inflammation and pathologies can be mitigated by in vivo supplementing of ST6Gal-1; and 3) assess the relationship of circulatory ST6Gal-1 levels in patients with atopic asthma during exacerbations and asymptomatic periods, and normal volunteers. The goal of the proposed research is to generate the foundation data for future efforts that will focus on developing ST6Gal-1 as a potential early predictor and prognostic marker of allergic airway disease and as a therapeutic target for drug development. Show more... | National Institutes of Health | 6/04/2009 |
| HEALTH RESEARCH, INC. | $249,875.00 | Grant | Trans-NIH Recovery Act Research Support To analyze how immune responses generated against respiratory viral infection impact immunological and pathological responses to a subsequent pulmonary bacterial infection. Our goal is to identify the molecules and pathways involved in increased susceptibility or protection against subsequent infections. We will evaluate the interactions between two pathogens (respiratory syncytial virus and non-typeable Haemophilus influenzae) that have direct relevance to otitis media and chronic obstructive pulmonary disease. Our studies will determine whether the age of the host during primary exposure to RSV infection influences the generation of anti-NTHI immune responses. Show more... | National Institutes of Health | 7/17/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $193,355.00 | Grant | Trans-NIH Recovery Act Research Support Consistent, albeit moderate alcohol consumption in human adults results in permanent alterations in the cerebellum that discretely disrupt motor functions and become more pronounced with age. This is a major health concern as the aging population continues to escalate. In aging rats, chronic ethanol consumption results in regression of Purkinje neuron (PN) dendrites, a process that surely alters cerebellar function as PN are the sole output neurons from the cerebellum. Ethanol-related dendritic regression is coupled with other degenerative changes in dendrites such as dilation of the smooth endoplasmic reticulum (SER), the major calcium storage component of PN dendrites. Dilation of the SER in PN dendrites is strongly suggestive of increases in intradendritic calcium, a second messenger signal for a myriad of neuronal pathways. Ethanol-related dilation of the SER also suggests that ethanol-related alterations may have occurred in the sarcoplasmic reticulum calcium ATPase (SERCA) pump that resequesters calcium into the SER lumen following calcium signaling. The overall goal of this proposal is to show that ethanol-related increases in intracellular calcium levels and declines in the levels and/ or function of the SERCA 2b calcium ATPase pump may be the driving force that culminates in PN dendritic degeneration in aging and alcohol-fed rats. Calreticulin, a calcium binding protein that interacts with the SERCA pump will also be examined. To achieve this goal, 12 mo old F344 male rats will be fed the AIN-93M ethanol (EF rats), AIN-93M control (PF) rats, or rat chow (CF rats) for a period of weeks. Young control rats will also be included in the analysis. To measure calcium within dendrites and specific dendritic components, acute cerebellar slices will be made following 10, 20, or 40 weeks of ethanol treatment, electroporated to facilitate Fura-2 entry into PN, and ratiometric calcium measures made on the slices. Levels of the SERCA 2b ATPase pump and calreticulin will be assessed with confocal microscopy, and fluorescence intensity correlation after treatment durations of 10, 20 or 40 weeks in proximal and distal dendritic branches, spines, and branchpoints. SERCA 2b pump function will be assessed by observing the ability of the PN to handle large calcium transients when calcium sequestration systems other than the SERCA pump are blocked and by assessing whether ethanol predisposes the neuron to thapsigargin-induced expression of caspase-12.and GRP78 It is predicted that chronic ethanol consumption will result in increases in intracellular calcium ions that will be related to ethanol-related declines in the function or expression of the SERCA 2b pump. Results from this study will provide a basis for future studies of the actions of ethanol on intracellular calcium homeostasis and the mechanisms that result in PN dendritic degeneration. PUBLIC HEALTH RELEVANCE: The elderly U.S. population will double by 2050, an escalation accompanied by a tremendous increase in the number of elderly lifetime alcohol consumers. Recent studies show that consistent, albeit moderate alcohol consumption in human adults results in permanent alterations in cerebellar- based motor coordination and also in the cognitive activities ascribed to the cerebellum's connections with the frontal lobe. Permanent deficits result from these alterations that become more prevalent with age and predispose our increasing elderly population to falls, accidents, and cognitive dysfunctions. Show more... | National Institutes of Health | 8/17/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $535,271.00 | Grant | Trans-NIH Recovery Act Research Support Chronic disease is a major contributor to health disparities, and complex chronic disease (multiple chronic conditions requiring multiple providers) is increasingly common. Literature suggests that individuals with chronic disease receive less preventive cancer screening than individuals without a chronic disease, but little research is available to assess the incorporation of preventive cancer screening among patients with complex chronic disease (CCD). For minority populations with limited resources and disproportionate rates of some chronic conditions, this may contribute to poorer outcomes and greater disparities. This study will build upon a well established partnership of university and community collaborators to assess barriers to and motivators for preventive cancer screening and will design a patient-driven intervention to incorporate cancer screening into chronic disease management. The Community Based Participatory Research (CBPR) team will be jointly led by 2 PIs, one from the community and one from a university. A CBPR Steering Committee will include 4 researchers from a School of Medicine, a School of Public Health, and a Cancer Research Institute, 2 community-based organizations, 2 primary care practices serving predominantly minority low- income patients, and a Patient Action Team of patients with CCD. The study aims are to: (1) conduct a cross-sectional study to describe cancer prevention screening among patients with CCD; (2) design a pilot cancer-prevention intervention with a Patient Action Team (composed of patients with CCD) based on patient-reported factors that enable or hinder cancer prevention screening among adults with CCD in low- income, minority communities; and (3) conduct a pilot cancer-prevention intervention among patients with CCD in preparation for a larger CBPR Roll study. Specifically, this study will develop a registry of patients with complex chronic disease from 2 community medical practices. The registry will be used to: (a) conduct a descriptive cross-sectional study to explore disparities in cancer prevention screening (Aim 1); (b) recruit patients with CCD to serve on a Patient Action Team to design an intervention (Aim 2); and (c) recruit patients with CCD to pilot test the patient-centered intervention (Aim 3). RELEVANCE (See instructions): The prevalence of adults with multiple chronic diseases is increasing. This proposal will establish a university-community partnership to engage patients with complex chronic disease living in predominately minority low-income communities to collaborate in developing an intervention to improve cancer prevention screening. The intervention will be based on patient perceptions of need, priority, barriers, and motivators to include preventive cancer screening as part of their patient-centered care regimen. Show more... | National Institutes of Health | 9/21/2009 |
| COMMUNITY HEALTH CENTER OF BUFFALO, INC. | $535,880.00 | Grant | ARRA-Health Center Integrated Services development Initiative ARRA ? Capital Improvement Program: CIP funds will be used to underwrite part of the cost of constructing a 36,000 sq. ft. building to allow the Community Health Center of Buffalo, Inc. (CHCB) to increase access to care for underserved populations. The CHCB building will have two floors and a 150-car surface parking lot. Phase 1, to be completed using CIP funds, includes 24,000 sq. ft. On the first floor will be a waiting room, exam rooms, procedure rooms, social work, a 340 pharmacy, and the billing department (Phase 1). Administrative offices will be on the second floor. The CHCB?s number of medical exam rooms will increase from 16 to 21. A main entrance and separate access points are planned for staff and for service/loading. The building will have two elevators and will be fully handicap accessible. The impact of the CHCB serving as a primary care hub for Buffalo will be to improve access of the medically underserved to high quality, comprehensive and culturally sensitive primary care, including appropriate specialty services. Construction of a new primary care facility offers the opportunity to develop collaborative services between the CHCB and major hospital systems in Buffalo, NY. The CHCB will act as the ?hub? or entry point to the health care delivery system in Buffalo. Collaborative agreements link CHCB to hospitals and specialists into a mutually beneficial network that reduces barriers to accessing care. The CHCB will work towards an integrated health care delivery system designed to: 1) improve the effectiveness of primary care services; 2) reduce the overall health care costs; 3) broaden access to services; and 4) improve targeting services to identified health problems in the community. Using health information technology, the CHCB will become more data driven to improve individual patient care and operational efficiencies. There will be increased access to comprehensive care management because the CHCB approach integrates a continuum of services (outreach, risk assessment, education, prevention, medical care, social support and follow-up) to improve community wellness. There will be 5 FTE health care jobs created. There will be 27 FTE construction jobs created. The Project Team is headed by Dr. LaVonne Ansari. She has more than 20 years of combined experience in workforce development and business administration, health care, higher education, and EEO/affirmative action compliance. Richard T. Pope, CPA, is the Financial Director and Chief Financial Officer for CHCB. He is a graduate of State University of New York at Buffalo with a B.S. Degree in Business Management. Employment history reflects 20 years of financial experience. The CHCB governing board has unanimously approved this project and is committed to this expansion of services. Stievater + Associates: architects has over 20 years medical design experience, including about 50 projects over the last 15 years. Casilio Companies will provide construction management. Since its founding, the Casilio Companies has developed over 20 million sq. ft. of space. Construction Management and general construction projects include medical surgical units and corporate offices. The CHCB will conduct outreach to the disconnected and unconnected medically underserved individuals and special needs populations. The CHCB envisions the new location as a gateway for a wide spectrum of activities that promote wellness. Show more... | Health Resources and Services Administration | 6/25/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $51,710.00 | Grant | Trans-NIH Recovery Act Research Support Manganese (Mn) intoxication, a syndrome known as manganism, is most often associated with prolonged occupational exposure, although individuals with cirrhosis of the liver and related hepatic dysfunction display many of the behavioral and neurological symptoms associated with this disorder. The most prominent symptom from overexposure comprises an irreversible extrapyramidal dysfunction resembling that of Parkinson's disease. Manganism, however, is associated with the preferential degeneration of GABAminergic neurons within the globus pallidus and not the dopaminergic neurons in the substantia nigra. Although the neurotoxic mechanisms provoking increased susceptibility of pallidal neurons to the toxic actions of Mn is not fully understood, there is increasing evidence that the excitatory neurotransmitter, glutamate, as playing a role in the degenerative actions of Mn since neurons within the globus pallidus normally receive glutaminergic input from cells within the subthalamic nuclei. This is supported by studies demonstrating that blocking of the glutamate receptors with the NMDA receptor antagonist, MK-801, prevents lesions produced by intrastriatal injections of Mn. This raises the issue that the selective neurotoxic actions of Mn on pallidal neurons may not be caused by any one factor but are likely an amalgamation of several processes occurring simultaneously which include 1) accumulation of Mn in the globus pallidus, 2) similarity between the cytotoxic actions of glutamate and Mn involving mitochondrial dysfunction leading to oxidative stress, 3) Mn inhibition of astrocytic glutamate transport and metabolism leading to increase synaptic levels of glutamate and 4) increased uptake of Mn in pallidal neurons by activated glutamate channels. Thus, it is reasonable to hypothesize that treatment of Mn overdoses with a drug which inhibits both glutamate release and oxidative stress may prove useful in the initial stages of manganism. Interestingly, there is a drug on the market, riluzole, currently approved for treatment of amyotrophic lateral sclerosis (ALS), which mechanistically behaves in this fashion. Riluzole functions by inhibiting glutamate release as well as its actions as both an antioxidant and an antagonist of the ionotropic glutamate receptor. Thus, the combined pharmacological actions of riluzole as both an antioxidant and inhibitor of glutamate activity may make it an ideal drug for the treatment of manganism. As will be described in more detail in this proposal, our preliminary studies, in fact, support this hypothesis. Accordingly, the studies proposed in this grant are designed to 1) examine the mechanism by which glutamate facilitates Mn toxicity, 2) characterize the biochemical mechanisms responsible for the neuroprotective actions of riluzole and 3) demonstrate the neuroprotective actions of riluzole in Mn exposed mice. PUBLIC HEALTH RELEVANCE Overexposure to high atmospheric levels of manganese can lead to a syndrome characterized by an irreversible extrapyramidal dysfunction resembling that of Parkinson's disease. Although it is known that manganism is associated with the preferential degeneration of GABAminergic neurons, the mechanism for this selective toxicity is not fully understood. Thus, the studies proposed in this grant is relevant to human health in that it will investigate new mechanisms to explain the selective toxic actions of manganese in human brain and provide the necessary preliminary evidence to demonstrate the application of the drug, riluzole, for treatment of this debilitating and irreversible disorder. Show more... | National Institutes of Health | 7/17/2009 |
| BUFFALO CITY OF | $2,616,421.00 | Grant | 16.804 - Recovery Act - Justice Assistance Grants - Localities Jag stimulus funding engages a partnership between the City of Buffalo and 11 suburban law enforcement partners focusing on crime reduction through job creation/preservation; purchasing equipment and technology and community initiatives that promote safety partnerships between the police and the community. Deliverables include: selective enforcement overtime, job creation in criminal justice agencies and community-based providers; prevention/intervention opportunities and re-entry services, as well as replacing obsolete and unserviceable police equipment. Show more... | Department of Justice | 5/29/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $111,220.00 | Grant | Trans-NIH Recovery Act Research Support The long term goal of our research is to develop an acoustically-based, explanatory model of the communication deficit in dysarthria that can be used to guide and justify treatment decisions. Toward this end, the proposed Phase I treatment project will investigate the relationship among phonatory and supralaryngeal acoustic measures of speech, intelligibility, and speaking conditions used as intervention strategies for dysarthria secondary to Parkinson disease and Multiple Sclerosis. Studies from the first funding cycle indicated that vowel distinctiveness was maximized in a Slow condition while consonant distinctiveness and intelligibility were maximized in a Loud condition. Supralaryngeal acoustic measures also accounted for only a portion of the variance in intelligibility. Whether a speech mode encouraging a slowed rate and increased intensity would yield improvements in acoustic-phonetic distinctiveness and intelligibility above those associated with rate reduction or increased loudness alone is unknown, although the Perceptual-Acoustic Theory (Perkell et al., 2000) predicts such an outcome. The proposed project tests this and other predictions of the Perceptual-Acoustic Theory by extending the study of speech mode effects in dysarthria to Clear speech, a speech mode encouraging a slowed rate and increased intensity. The contribution of acoustic measures of phonatory behavior to intelligibility as well as measures of acoustic-phonetic distinctiveness also will be studied. Loud, Slow, Clear, and even Fast speech modes are used therapeutically to maximize intelligibility in dysarthria, yet comparative group studies are lacking. Research that improves our understanding of acoustic-perceptual changes associated with these speech modes would strengthen the scientific bases of treatment techniques and may reveal acoustic-perceptual advantages of a given speech mode that will determine preferred therapies - key considerations for evidence based practice. The overarching hypothesis to be evaluated is that intelligibility and acoustic-phonetic distinctiveness will be maximized in conditions associated with increased effort, as indexed by SPL, and for which a slowed rate is encouraged, whereas phonatory function will be maximized in conditions associated with increased effort. This hypothesis is suggested by the Perceptual-Acoustic Theory, which posits a trade-off between effort and acoustic-perceptual adequacy as well as articulatory rate and accuracy. Show more... | National Institutes of Health | 9/03/2009 |
| HEALTH RESEARCH, INC. | $127,220.00 | Grant | Trans-NIH Recovery Act Research Support Many organisms show daily oscillations of various physiological and behavioral processes, which are generated by a genetically determined circadian clock system. It is believed that the circadian system has evolved to provide the most efficient responses to changing environmental stimuli. Disruptions of circadian rhythms are often associated with pathological conditions; on the other hand, many types of illnesses (heart attacks, stroke, asthma etc.) show patterns of daily variation. Responses to different medications, and therefore the efficiency of treatment, may be significantly affected by the functional status of the circadian clock system. At the molecular level, circadian rhythms are generated by periodic changes in the expression levels of large groups of genes regulated by the components of the molecular circadian oscillator. Currently accepted model of the molecular circadian oscillator is based on a transcription-translation negative feedback loop. However, this model cannot provide comprehensive explanation for the circadian rhythms phenomena. In fact, we have demonstrated that circadian transcriptional complex possesses both transactivation and transrepression properties. Based on these observations, we propose a new concept of circadian system organization, suggesting that active circadian repression plays an important role in oscillator's operation and circadian control of responses to the environment. The current program is devoted to: (i) study of the functional role of posttranslational modifications of circadian transcriptional regulators and identification of proteins that involved in these modifications; (ii) understanding of the basic molecular mechanisms of the activation/repression function of circadian transcriptional regulators; (iii)the development of potential pharmacological modulators of circadian system through the high throughput screening of the chemical libraries using cell-based readout system. The completion of this program should not only bring this problem to a new level of understanding but will also help defining new targets for pharmacological modulation of circadian rhythmicity. Show more... | National Institutes of Health | 9/18/2009 |
| HEALTH RESEARCH, INC. | $356,346.00 | Grant | Trans-NIH Recovery Act Research Support The aim of this funded R21 proposal is to study the role of dietary supplement selenium (Methylselenocysteine or MSC) in supranutritional doses in retarding cancer growth and synergistically enhancing chemotherapeutic efficacy in combination setting through its? antiangiogenic activity. This antiangiogenic effect lead to tumor blood vessel normalization that enabled delivery of higher drug within the tumor at a given systemic drug dose administered. This effect was hypothesized to be through down regulation of reactive oxygen species leading to HIF-1á degradation. The proposal uses six different human cancer xenografts from three cancer disease sites ? Head and Neck, Colorectal and Lung. The specific aims of the proposal are as under: Specific Aim 1: Evaluate the effect of Se on antioxidant and vascular (antiangiogenic and normalization) status in tumor xenografts growing sub cutaneously (s.c) in nude mice. Specific Aim 2: Evaluate the effect of Se on tumor vascular volume and permeability using noninvasive dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). Specific Aim 3: Evaluate the effect of Se in vitro on ROS, antioxidants, HIF-1á degradation and on downstream angiogenic markers VEGF, PDGF-B, and MMP-14. Show more... | National Institutes of Health | 6/04/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $380,818.00 | Grant | Trans-NIH Recovery Act Research Support The long term goal of this project is to elucidate the roles protein arginine methylation in Trypanosoma brucei gene expression, particularly at the RNA level. These studies will greatly increase our understanding of gene regulation in a medically and economically important parasite. In addition, because the effects of arginine methylation on RNA metabolism are not well understood in general, they will also provide insight into a common posttranslational modification in higher eukaryotes. Show more... | National Institutes of Health | 7/17/2009 |
| HEALTH RESEARCH, INC. | $178,718.00 | Grant | Trans-NIH Recovery Act Research Support This funding will allow us to promote job creation and economic development as it accelerates the pace and achievement of the scientific research as outlined in our parent grant, one of the seven NIH-funded Transdisciplinary Tobacco Use Research Centers (TTURCs). In recognition of the threat that tobacco use poses to global public health, in 2003, the member countries of the World Health Organization adopted the Framework Convention on Tobacco Control (WHO FCTC), the first international treaty devoted to health. As a result of the FCTC, national-level policies and programs designed to reduce tobacco use have proliferated. Good quality evaluation, including capacity to understand any differential by-country effects, will be a critical aspect of fulfilling FCTC obligations to deliver the optimum mix of evidence-based policies. The central aim of the Roswell Park TTURC has been to apply rigorous methods to evaluate the psychosocial, behavioral, and product-related impact of tobacco control policies implemented as part of the FCTC. The Roswell Park TTURC is one of the principal funding arms of the International Tobacco Control (ITC) Policy Evaluation Collaborative. Since its inception in 2002, the ITC Project has conducted cohort surveys of large samples of smokers in 20 countries inhabited by over 50% of the world?s population, 60% of the world?s smokers, and 70% of the world?s tobacco users. All surveys contain questions addressing each of the demand reduction policies of the FCTC. Through this administrative supplement, we will hire two doctoral students enrolled at the State University of New York at Buffalo to perform secondary data analyses to allow us to examine whether the effects of FCTC policies on tobacco use behaviors and psychosocial mediators of behavior differ as a function of socioeconomic status. We will also examine whether SES influences tobacco use behaviors and psychosocial mediators of tobacco use in the same way in all ITC countries. The supplement will produce a series of research papers focused on six FCTC policy domains. These papers will be compiled into a journal supplement for researchers and policymakers that describes how tobacco control policies may or may not exert differential impact in different populations. These topics are outlined below. Paper FCTC Policy Domain Policy Relevant Research Questions 1. Tax and price: Are low SES smokers more likely to quit in response to price increases? Are higher SES smokers more likely to avoid paying high cigarette taxes? Are low SES smokers more likely to switch to discount brands or roll your own cigarettes? 2. Clean indoor air: Are low SES populations more likely to see secondhand smoke exposure reductions? Do population subgroups respond differently with respect to hospitality patronage, quitting, and displacement of smoking from pubs to the home? 3. Product labeling: Are product warning labels more effective in lower SES population? Does the impact of warning labels and low tar descriptor bans diminish over time? Are there gender differences in response to warning labels? 4. Cessation treatment: Has the UK policy to improve access to cessation treatments reduced SES disparities in use of evidence based treatment strategies? Is access to evidence based treatment approaches increasing the same across different SES groups? 5. Marketing: Are there differences in exposure to pro- and anti-tobacco marketing across SES groups? Have policies restricting tobacco product advertising had the same effects in different SES groups? 6. Product regulations: Are misperceptions about light cigarettes the same across SES groups? Has the removal of misleading product labeling such as light and mild had the same effects in different SES groups? What effect has establishing maximum tar levels had on smoking habits of smokers in different SES groups? Show more... | National Institutes of Health | 8/31/2009 |
| HEALTH RESEARCH, INC. | $397,991.00 | Grant | Trans-NIH Recovery Act Research Support A critical component of the acute inflammatory response is the rapid mobilization of blood-borne lymphocytes into secondary lymphoid organs. These organs are the staging ground for lymphocyte encounters with antigens and foreign pathogens during the initiation of protective immunity. Significant progress has been achieved in defining the adhesion events that guide homeostatic steady-state trafficking of lymphocytes across vascular checkpoints in lymphoid organs. By contrast, the molecular basis of inducible trafficking of naïve and central memory cells to lymphoid organs during inflammation is poorly understood. Extensive preliminary data lead us to hypothesize that the proinflammatory cytokine, interleukin-6 (IL-6), is a driving force in regulating lymphocyte migration into lymphoid organs during acute inflammation. The first aim will identify the cellular source of IL-6 that regulates the capture efficiency of vascular gateways in a model of systemic febrile inflammation. Reciprocal bone marrow chimeras with wild-type and IL-6-deficient mice will segregate whether IL-6 production by radiation-resistant stromal cells or radiation-sensitive hematopoietic cells is required for enhanced lymphocyte trafficking across vessel walls during febrile stress. Homing assays and intravital microscopy will validate whether radiation-sensitive hematopoietic cells or radiation-resistant stromal cells are the primary source of IL-6 that promotes lymphocyte influx into lymphoid organs. Aim 2 will focus on determining if IL-6 is also responsible for mobilizing the recruitment of naïve T cells to local inflamed lymph nodes during an adaptive immune response. These studies are based on our surprising discovery that IL-6 produced by mature dendritic cells (DC) modifies the adhesive properties of vascular entryways in draining nodes. Studies will determine whether DC act distally (at inflammatory sites) or locally (in draining lymph node) to regulate vascular endothelial adhesion. Understanding the cytokine requirements for lymphocyte recruitment during acute inflammation may lead to novel intervention strategies in chronic inflammatory disorders as well as provide insights into vaccine approaches based on the ability of cytokines to heighten adaptive immunity. Show more... | National Institutes of Health | 7/21/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $479,574.00 | Grant | Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area (03) Biomarker Discovery and Validation, and specific Challenge Topic, 03-DE-101: Development, Refinement, or Validation of Biomarkers Relevant to Oral or Craniofacial Disorders. The goal of this proposed study is to measure a series of inflammatory biomarkers in saliva and serum to examine to what extent non-invasive salivary biomarkers can be used to characterize those same biomarkers measured in serum. We propose to assess inflammatory biomarkers in saliva and serum samples that are available from previously collected and frozen samples from two funded and completed federally supported studies investigating the association of osteoporosis and periodontal disease (DOD #OS950077; R01DE013505). Samples of saliva and blood were collected, processed and stored using standardized protocols at baseline (DOD study) and again in the same participants prospectively approximately 5 years later (R01). Participants were postmenopausal women recruited into these 2 ancillary studies from the University at Buffalo clinical center of the NIH Women's Health Initiative Observational Study. These stored samples are a unique resource that will be used to measure a panel of inflammatory biomarkers selected for their potential importance in both oral and systemic health. The stored samples were collected at two time points (baseline and 5 years later) at clinic visits. Both saliva and serum blood were collected from these participants on the same day and immediately processed for frozen storage. At these same visits, oral examinations were conducted according to standardized protocols to assess indices of oral and periodontal health (CAL, ACH, bleeding, plaque, calculus, tooth loss, DMFT, oral bone density). Assessments of bone density (DXA), body composition and other physical measures were obtained. Information was collected on participant demographics, personal habits, lifestyle factors, psychosocial factors, dietary intake, physical activity, medication/supplement use, occupation, family history, health practices and medical history. The primary aim of this proposed study is to measure a panel of biomarkers of inflammation in stored saliva samples and determine to what extent salivary levels of these biomarkers are able to characterize these same biomarkers measured in samples of stored serum (N=920). We also propose to determine to what extent the levels of these biomarkers and their relationship to each other change over time (collected at baseline and 5 years later, N=400). In addition, we will determine to what extent baseline markers in salvia and in serum are able to characterize prevalent periodontal disease at baseline, and predict incidence of new and progression of existing periodontal disease (N=920). These data are critically important and significant for several reasons. First, if we are able to characterize serum levels of these biomarkers using saliva, this would provide a novel and non-invasive method of assessing systemic inflammation in older women, which could have many applications. Second, the information collected here will allow us to develop prediction models for incident periodontal disease and also for progression of existing disease. Third, although the focus of this proposed study is to utilize the biomarkers to characterizing periodontal disease, the salivary biomarkers measured in saliva could be used more generally in other chronic diseases thought to be associated with inflammation. For example, in this cohort we would be able to explore salivary biomarkers in the prediction of bone density and osteoporosis which is well characterized in this cohort. We may be able to explore the relation in other chronic diseases that are also assessed as part of routine outcomes collection in WHI. The complete abstract for this award is available at http://report.nih.gov/recovery/? Show more... | National Institutes of Health | 9/22/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $210,117.00 | Grant | Trans-NIH Recovery Act Research Support The application addresses the broad Challenge Area (15) Translational Science and Specific Challenge Topic, 15-ES-101; Effects of environmental exposures on phenotypic outcomes using non-human models. This application will apply non-human modeling to examine a genetic mutation which may be responsible for increasing susceptibility to develop manganese (Mn) toxicity. Chronic exposure to the Mn has been linked to development of a severe, irreversible neurological disorder known as manganism consisting of reduced response speed, intellectual deficits and mood changes in the initial stages of the disorder to more prominent and irreversible extrapyramidal dysfunction resembling Parkinson's disease upon protracted exposure. Manganism is primarily an occupational disorder associated with environmental conditions in which workers are exposed to chronic high levels of the metal and include Mn miners, welders and those involved in ferroalloy processing. The CNS injury caused by Mn manifests in a diverse set of symptoms indicative of the fact that the basal ganglia is one of the most complex areas of the brain. When in excess, Mn disrupt the delicate balance between the well organized and interrelated components within the basal ganglia as a disturbance in any one of the elements, whether it occurs in the globus pallidus as in manganism or the nigro-striatal neurons as in Parkinson's disease, manifests in insidious neurological deficits that, in some respect, can appear remarkably similar. Differences in response to Mn overexposure in the human population, most likely, are due to underlying genetic variability which ultimately presents in deviations in both susceptibility as well as the characteristics of the neurological lesions and symptoms expressed. Although the underlying genetic defect responsible for increased susceptibility to develop manganism is not known, our preliminary findings revealed that the gene for early onset of Parkinson's disease, parkin, has the potential to regulate Mn toxicity and, thus for the first time, identify a potential genetic link between manganism and Parkinsonism. Parkin is an E3 ligase responsible for ubiquitinating a number of proteins destined for degradation via the proteasomal pathway. Of the known Parkinson's disease -linked genetic mutations correlating with early onset, those involving parkin are the most prevalent encompassing approximately 50% of all recessive Parkinson's disease cases. Our preliminary studies have now established (unpublished findings) that parkin is the E3 ligase responsible for the ubiquitination of the 1B isoforms of divalent metal transporter 1 (DMT1), the major protein for transport of Mn. These studies reveal that neuroblastoma cells overexpressing parkin display both decreased expression of DMT1 as well as increased toxicity towards Mn. Non-transformed human lymphocytes that are homozygous for the mutation in exon 4 of parkin express increased levels of the transporter as do brains from parkin knock-out mice. Although considered to be an autosomal recessive gene there is evidence in the literature suggesting that mutations in a single allele of the parkin gene may exert sufficient imbalance in dopaminergic activity to cause subclinical features of Parkinsonism and play a significant role in idiopathic Parkinson's disease. Thus, individuals that are heterozygous for the parkin mutation may similarly be at greater risk to develop Mn toxicity. In addition to the ability of parkin to alter DMT1 expression, mutations in the gene have also been reported to regulate activation of a number of signaling processes associated with Mn toxicity. The complete abstract for this award is available at http://report.nih.gov/recovery/ Show more... | National Institutes of Health | 9/26/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $389,357.00 | Grant | Trans-NIH Recovery Act Research Support We appreciate the opportunity to refocus this application to achieve a single important aim related to our understanding of young adults' use of male liquor (ML), other alcoholic beverages, and marijuana (MJ), all of which confer high risks for experiencing negative consequences, including addiction. As we have noted, reviews of this grant application, have noted numerous strength, which are summarized below. a) Malt liquor use is an understudied topic and the use of ML, other alcoholic beverages, and MJ are important public health issues. 2) The proposed research is highly innovative and long overdue. 3) The proposed research is based on a well-articulated conceptual framework and uses careful (i.e., methodologically rigorous) study design. 4) The application is well-written and in response to previous reviews includes assessment of the use of all alcoholic beverages, not just ML. 5) This research team has previous been successful in recruiting a large (> 600) sample of regular ML drinkers. 6) The research environment is excellent and the research team is very productive and led by a PI who is a leader in the alcohol and drug field. Given the previous reviewers' approval of the conceptual model, design, and measures proposed in this application, in this document begin by highlighting the following the following: 1) Selection of one specific aim that can be achieved within the 2 years of available funding and a brief overview of how that aim is reflected in the research design and methods; 2) Submission of a detailed budget similar in total costs to 2 years of the budget submitted as part of the earlier application; 3) Description of the ways in which funding this research stimulates the economy of the Buffalo metropolitan region and the nation; and 4) A description of timelines and milestones to be achieved during the 2-year period. The document ends with a detailed description of the significance of the proposed research. Show more... | National Institutes of Health | 5/07/2009 |
| HEALTH RESEARCH, INC. | $208,350.00 | Grant | Trans-NIH Recovery Act Research Support The aim of this funded R21 proposal is to study the role of dietary supplement selenium (Methylselenocysteine or MSC) in supranutritional doses in retarding cancer growth and synergistically enhancing chemotherapeutic efficacy in combination setting through its? antiangiogenic activity. This antiangiogenic effect lead to tumor blood vessel normalization that enabled delivery of higher drug within the tumor at a given systemic drug dose administered. This effect was hypothesized to be through down regulation of reactive oxygen species leading to HIF-1á degradation. The proposal uses six different human cancer xenografts from three cancer disease sites ? Head and Neck, Colorectal and Lung. The specific aims of the proposal are as under: Specific Aim 1: Evaluate the effect of Se on antioxidant and vascular (antiangiogenic and normalization) status in tumor xenografts growing sub cutaneously (s.c) in nude mice. Specific Aim 2: Evaluate the effect of Se on tumor vascular volume and permeability using noninvasive dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). Specific Aim 3: Evaluate the effect of Se in vitro on ROS, antioxidants, HIF-1á degradation and on downstream angiogenic markers VEGF, PDGF-B, and MMP-14. Show more... | National Institutes of Health | 4/28/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $77,439.00 | Grant | Trans-NIH Recovery Act Research Support Voltage-sensitive potassium (Kv) channels are proteins that exist in the membranes of all electrically excitable cell types. Kv1.4 (the mammalian homologue of Shaker) and all Kv4 (Shal-type) subunits generate potassium-selective current phenotypes designated 'Ito' in cardiac myocytes and 'IA' in neurons. Due to their rapid activation and subsequent inactivation kinetics, both channel types can significantly modulate action potential repolarization and frequency-dependent electrical signaling. IA/Ito phenotypes have thus been hypothesized to play important functional roles in both the cardiovascular and nervous systems. In particular, Kv4 channels have recently been importantly implicated in neural mechanisms underlying both memory and pain perception. While much is understood about molecular mechanisms underlying activation, inactivation, and recovery in Shaker/Kv1.4, the corresponding mechanisms in Kv4 are presently undetermined. Nonetheless, there is general consensus that 'conventional' Shaker N- and C- type inactivation mechanisms are not involved. Kv4 channels also display prominent inactivation from pre-activated closed states (closed state inactivation or CSI), a process which is not significant in Shaker. Therefore, as an alternative to the conventional Shaker/Kv1.4 gating model, I hypothesize that transitions in the Kv4 voltage sensing domain (VSD), and in particular those mediated by S4 positively charged arginine (R) residues, are primarily responsible for regulating not only activation and deactivation, but also CSI and recovery. CSI thus either possesses inherent voltage dependence or is coupled to activation by a mechanism significantly different from that in Shaker. As a result, Kv4 recovery (from both open inactivated and closed inactivated states) will be coupled to deactivation. Using Xenopus laeavis oocytes as an expression system, a combination of mutagenic and functional kinetic analysis (two microelectrode voltage clamp, cut open oocyte voltage clamp) will be employed to gain initial insights into molecular and biophysical mechanisms underlying CSI and recovery of Kv4.3 subunits. The Specific Aim will be to develop novel methods for measurement of Kv4.3 subunit gating currents 'Ig' and to determine how various S4 arginine (R) mutants alter them. PUBLIC HEALTH RELEVANCE: Kv4 channels are important for normal functioning of the heart, and are believed to be directly involved in several functions/dysfunctions of the nervous system, including learning and memory, epilepsy, and pain perception. The proposed research will provide new molecular and biophysical insights into basic mechanisms regulating Kv4 channels, and may thus provide the basis for development of more effective therapeutic treatments. Show more... | National Institutes of Health | 7/16/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $78,810.00 | Grant | Trans-NIH Recovery Act Research Support Aggression and victimization are both risk factors for social-psychological adjustment problems and future psychopathology. The study of the developmental course of aggression and victimization among children is crucial for identifying children most at risk for future psychopathology (Cummings, Iannotti, & Zahn-Waxler, 1989; Keenan & Shaw, 1994). In children, subtypes of aggression and victimization (i.e., physical and relational) have been extensively studied and developmental psychopathologists have documented links between these behaviors and both externalizing and internalizing problems (Dodge, Coie & Lynam, 2006; Crick, Ostrov, & Kawabata, 2007). Peer relations researchers have revealed robust associations between relational aggression and victimization and hostile attribution biases, loneliness, and depressive symptoms (Crick et al., 2007). However, to date, these associations have been concurrent and possible developmental mechanisms have not been studied in prospective designs. Therefore, the proposed study will conduct a secondary data analysis of the NICHD Study of Early Child Care and Youth Development to test three hypotheses. We hypothesize that hostile attribution biases for relational provocations, loneliness and depressed affect with independently partially mediate the prospective associations between relational aggression and relational victimization. PUBLIC HEALTH RELEVANCE: The goal of this research is to better understand the types of behaviors that may be associated with maladaptive developmental trajectories for both boys and girls. The proposed research will permit the field to move closer toward understanding the developmental mechanisms that promote peer victimization and will provide implications for the development of prevention and intervention efforts during middle childhood. Show more... | National Institutes of Health | 8/14/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $1,312,909.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Rural Are
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 3/19/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $725,769.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Urbanized
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 3/19/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $13,378,488.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 4/29/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $570,000.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 3 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 7/01/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $1,092,868.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 4/29/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $220,000.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 2 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 6/18/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $250,000.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 5/26/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $130,000.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 4/29/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $587,696.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 4/29/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $959,000.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Urbanized
There were 4 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 7/01/2009 |
| CLEVELAND BIOLABS, INC. | $2,844,359.00 | Grant |
Trans-NIH Recovery Act Research Support The severity of radiation injury in humans is largely determined by high sensitivity of the gastrointestinal (GI) tract, yet no drugs are approved for this indication. This award is focused on a novel, clinical-stage drug candidate, Protectan CBLB502, a Toll-like receptor 5 (TLR5) agonist capable of effective mitigation of otherwise lethal radiation-induced GI injury in mice and non-human primates (NHPs). A comprehensive understanding of mechanisms of action is required for drug development under the FDA Animal Efficacy Rule. Accordingly, the main objective of this proposal is to use mouse and NHP models to charaterize in detail the mitigating effect of CBLB502 on various elements of the GI system and to identify cellular and molecular mediators of this effect. Specifically, our multi-institutional collaborative team will: (i) create a comprehensive 'histological atlas' illustrating the mitigating effects of CBLB502 on various elements of GI infrastructure damaged by radiation, (ii) define the target organs that contribute to the GI radiomitigation activity of CBLB502 with specific focus on bone marrow and liver, and (iii) identify primary and secondary cellular and molecular conductors of the radiomitigating function of the drug as well as novel efficacy biomarkers. Completion of this program should create a solid mechanistic base for translation of animal data into a well-justified projected human efficacious dose and will be critical for FDA approval of CBLB502 as a medical countermeasure to mitigate GI radiation damage. Show more...
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
National Institutes of Health | 9/25/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $68,917.00 | Grant | Trans-NIH Recovery Act Research Support Myocardial infarction is a major cause of morbidity and mortality in the United States and most developed countries. Heart transplantation is an effective therapeutic modality in reconstituting the function of damaged heart. However, widespread application of this modality is severely limited due to the scarcity of organ donors and complications associated with the required immunosuppression. Cell therapies aiming at replacing infarcted heart muscle are highly desirable. Embryonic stem cells (ESCs) can serve as an inexhaustible source of cellular material for repairing damaged myocardium. Human ESCs (hESCs) have been shown to differentiate towards functional cardiomyocytes. Nonetheless, clinical realization of stem cell-based therapies for heart repair will require the production of ESC-derived cardiomyocytes in large numbers. Current methodologies entail the propagation and differentiation of ESCs in static cultures (e.g. dishes) which are challenging to scale-up. To that end, large cell quantities can be generated under tightly controlled culture conditions in scalable stirred-suspension bioreactors. We have discovered that mouse ESCs cultivated in a bioreactor can be expanded several fold and differentiate to multiple lineages. We hypothesize that hESCs cultured as aggregates in stirred-suspension vessels can also propagate to high concentrations. We propose to culture hESCs in a stirred bioreactor culture system and determine conditions which favor the growth of hESCs without compromising their viability. Furthermore, hESC differentiation to cardiomyocytes is carried out mainly while hESCs are organized as aggregates or embryoid bodies. Therefore, expansion of hESCs as aggregates in the bioreactor may be followed by switching to conditions directing the cells to adopt a cardiomyocyte fate. We will evaluate the cardiogenic potential of hESCs cultured as aggregates in the bioreactor. The resulting cells will be characterized for the expression of cardiomyocyte-associated genes/proteins and will be subjected to functional assays in vitro. This study will yield new information benefiting the development of bioprocesses for the generation of large quantities of hESC-derived cardiomyocytes suitable for infracted heart therapies. PUBLIC HEALTH RELEVANCE Myocardial infarction-induced heart failure is a prevailing cause of death in the United States and clinical therapies aiming at replacing or restoring damaged heart muscle are lacking. Stem cells with their extensive proliferative capacity and their ability to differentiate towards functional cardiomyocytes may serve as a renewable cellular source for regenerative heart therapies. This project seeks to further our understanding of the effects of bioreactor culture on the cardiogenic potential of human embryonic stem cells and to advance the bioprocess technology for the production of stem cell-derived cardiomyocytes in clinically relevant quantities. Show more... | National Institutes of Health | 7/23/2009 |
| HEALTH RESEARCH, INC. | $491,634.00 | Grant | Trans-NIH Recovery Act Research Support To obtain a detailed understanding of both innate and adaptive immune responses to bacterial pathogens that cause repeated respiratory tract infections in chronic obstructive pulmonary disease (COPD) patients. We are studying how key outer membrane antigens of the bacteria that are responsible for exacerbations of COPD stimulate innate and adaptive immune responses and how their cross-talk accounts for some of the lung damage that is manifested during the disease. An understanding of these processes will be crucial to the strategies to vaccine development and patient management. Show more... | National Institutes of Health | 7/17/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $250,000.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 5/26/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $142,988.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 4/29/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $1,204,000.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Urbanized
There were 3 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 7/01/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $900,000.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 2 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 5/19/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $50,000.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 2 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 6/15/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $370,000.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 5/26/2009 |
| NORTHWEST BUFFALO COMMUNITY HEALTH CARE CENTER | $559,995.00 | Grant | ARRA-Health Center Integrated Services development Initiative Capital Improvement Project | Health Resources and Services Administration | 6/25/2009 |
| BUFFALO URBAN RENEWAL AGENCY | $4,311,494.00 | Grant | Community Development Block Grant ARRA Entitlement Grants (CDBG-R)(Recover CDBG-R activities include a variety of community development projects including rehabilitation of single and multi family residential units, infrastructure (streets/sidewalks) improvements, demolitions, a job training program, and funding for administration. Show more... | Department of Housing and Urban Development | 8/14/2009 |
| CHEEKTOWAGA, TOWN OF | $273,744.00 | Grant | Community Development Block Grant ARRA Entitlement Grants (CDBG-R)(Recover Installation of drainage system on 2 streets and r | Department of Housing and Urban Development | 6/05/2009 |
| AMHERST, TOWN OF (INC) | $158,675.00 | Grant | Community Development Block Grant ARRA Entitlement Grants (CDBG-R)(Recover CDBG-R funds to replace 500 linear feet and re-lin | Department of Housing and Urban Development | 8/10/2009 |
| HAMBURG, TOWN OF | $126,675.00 | Grant | Community Development Block Grant ARRA Entitlement Grants (CDBG-R)(Recover The Town of Hamburg through its Department of Community Development and in conjunction with its Engineering Department will be replacing 6' waterlines on State Street with new 8' water lines. The project will improve water-flow, water quality and fire protection to a low/mod income neighborhood. This project will also create temporary jobs for the company who bids lowest for this project. This project will assist in preserving and creating jobs and promoting economic recovery. Also, this project will be investing in infastructure that will provide long-term economic benefit. It is expected thate there will be 1.14 full time equivalent jobs created if using the given formula. More realistically, there will be a short term or temporary job creation of six to ten jobs for the length of the project. This project will promote energy conservation by replacing older, leaking, inefficient 6' water line with a new 8' water line that will eliminat leakage, thus conserving water and increasing water pressure within this neighborhood. Show more... | Department of Housing and Urban Development | 8/10/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $50,000.00 | Grant | OFFICE OF SCIENCE FIN ASST PROGRAM The proposed work will provide mechanistic insight and fundamentally advance the three key performance metrics for energy storage: energy density, power delivery, and reversibility. These goals will be realized through development and study of a new class of bimetallic energy storage materials. Show more... | Argonne Site Office | 9/28/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $558,617.00 | Grant | Trans-NIH Recovery Act Research Support Infections caused by Staphylococcus aureus span a wide clinical spectrum, ranging from asymptomatic nasal carriage to endocarditis, bone and joint infections and lethal shock. Increasing rates of S. aureus infection and the emergence of community-acquired strains drive the need for an increased understanding of the virulence determinants of this emerging pathogen and evaluating the role they play in outcome of patients with S. aureus bacteremia. Evaluating the role of these virulence determinants in humans was limited by the absence of a large, well-characterized collection of bloodstream S. aureus isolates. Such a clinical resource was developed by Vance Fowler (Co-Investigator), when he created one of the world. Show more... | National Institutes of Health | 9/24/2009 |
| HEALTH RESEARCH, INC. | $173,231.00 | Grant | Trans-NIH Recovery Act Research Support RPCI is committed to focusing clinical research resources on processes that will improve the efficiency and effectiveness of study implementation, participant accrual and study data collection with an emphasis on investigator-initiated studies and Phase I studies. This proposal provides for an additional Clinical Research Services (CRS) staff and an Electronic Medical Record (EMR) Programmer (1.0 FTE). The EMR Programmer is needed to facilitate the EMR team in making needed changes that will improve clinical research processes to enhance accrual, prevent study protocol deviations, and enhance the collection of a complete and accurate dataset. The combination of the new CRS position and the 20% salary support for the CRS Educator who will provide consistent education for the investigators and the clinical research coordinators regarding the new EMR clinical research features will enhance the efficiency, effectiveness and accuracy of the RPCI clinical research processes: study implementation, participant accrual and accurate and complete data collection. Show more... | National Institutes of Health | 9/16/2009 |
| HEALTH RESEARCH, INC. | $50,000.00 | Grant | Trans-NIH Recovery Act Research Support The Roswell Park Cancer Institute (RPCI) has been continuously recognized as a Comprehensive Cancer Center since the NCI designation of such centers in 1974 and is now requesting continued federal support for the next five years. A free-standing research, education and clinical cancer care Institute, RPCI occupies a 27 acre campus near downtown Buffalo and has expanded to nearly 1.6M gsf of clinical and research space, a 16% increase since the last review period. RPCI serves a population base of ~1.5M in Western New York where the RPCI tumor registry is recording more than 3,400 new cancer patients per year. RPCI has strong collaborations with the University of Buffalo and the Hauptman-Woodward Institute for Structural Biology, but is a fully independent entity with Dr. Donald Trump, CCSG PI and RPCI President/CEO, answering only to the RPCI Board of Directors. Since the last competitive renewal, the RPCI has grown significantly as demonstrated by: 1) the recruitment of over 100 new faculty clinicians and researchers of which 43 are new CCSG members; 2) a 74% increase in total NCI funding and a 44% increase in total peer-reviewed funding; 3) a 73% increase in accrual to investigator-initiated, interventional clinical trials and a 44% increase to accrual in all interventional trials; 4) the addition of 4 new shared resources with an institutional investment of over $2.0 M and (5) the opening of a new, 177,000 gsf, state-of-the-art research building housing Program member laboratories and Shared Resources. With the growth in faculty has also come the recruitment of three Senior Leaders. In addition, a director for the newly created RPCI Office of Cancer Health Disparities Research has also been recruited. As part of the scientific growth within RPCI, a new disease-specific Research Program, the Prostate Program, has been added in this renewal bringing RPCI to a total of six Scientific Programs that also include Cancer Prevention & Population Sciences, Cell Stress & Biophysical Therapies, Genetics, Molecular Targets & Experimental Therapeutics and Tumor Immunology & Immunotherapy. With strong leadership and institutional commitment, RPCI will continue to focus on recruiting talented investigators to further expand research efforts targeting areas in genetics, investigational imaging and cancer health disparities. Show more... | National Institutes of Health | 9/21/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $43,200.00 | Grant | Trans-NIH Recovery Act Research Support This is a revised AITRP proposal for a postgraduate training initiative with an emphasis on HIV/AIDS clinical pharmacology between the University at Buffalo (UB) and the University of Zimbabwe (UZ). The program faculty at both institutions are experienced investigators that will contribute mentored training to UZ students who, in turn, will contribute clinical pharmacology expertise to multidisciplinary teams to achieve the HIV/AIDS research goals for Zimbabwe. The program is designed for AITRP trainees to benefit from mentored interactions with faculty and health professionals with established clinical/translational and laboratory research environments. The AITRP infrastructure has been broadened to include formalized collaboration with NIAID-funded international, multidisciplinary research networks in Zimbabwe, coordinated through the UZ Clinical Trials Site, as well as other US-supported and Zimbabwe-based research programs. This approach will provide opportunities for AITRP trainees to develop their research career during the AITRP and then continue in a collaborative, mentored environment after the training period. This revised application include0s a focused didactic curriculum for postgraduate trainees and an integrated research project experience that includes on-site training at UB and UZ. The AITRP will focus on a group of highly trained individuals who will then pursue their research programs within the multidisciplinary environment that is present at UZ with continued mentoring and career development. Strong institutional support for the proposed AITRP is evident through participation of faculty and administrative leaders at UZ in recognition of the need to support the development of future researchers to address the HIV/AIDS epidemic in Zimbabwe. PUBLIC HEALTH RELEVANCE: As the HIV/AIDS epidemic has continued to impact on developing countries, the need for training in HIV/AIDS clinical Pharmacology has also expanded in scope. Our AITRP meets these needs by providing a mechanism for multi-disciplinary training to conduct HIV/AIDS treatment research and achieve the goals that Zimbabwe has established for optimizing antiretroviral therapy and expanding its pool of clinician scientists. Show more... | National Institutes of Health | 9/03/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $744,973.00 | Grant | Trans-NSF Recovery Act Research Support Intellectual Merit All animals rely on their ability to sense and respond to their constantly changing environments to survive. Because they do not have eyes or ears, C. elegans (small roundworms) depend heavily upon their ability to taste and smell chemical information in their soil environment to find food and avoid danger; animals must move towards chemicals that indicate a food source while avoiding chemicals that indicate potentially harmful environments. These behavioral responses are elicited when the chemical signals (tastants and odorants) bind to proteins (receptors) on sensory nerve cells (neurons) and initiate a chain of intracellular events that ultimately activates the neuron. Neuronal activity, in turn, controls the behavior of the organism. Although this process of chemical signal transduction is highly conserved across species, there are still large gaps in our understanding of the mechanisms used to regulate signaling. Coupled with powerful genetic and molecular tools, C. elegans is an ideal model system in which to dissect the contributions of individual genes and regulatory pathways to integrated neuronal function and sensory behavior. Loss of a negative regulator of signaling (C. elegans GRK-2) surprisingly leads to decreased calcium signaling in sensory neurons and a concomitant loss of both attractive and avoidance chemosensory behaviors. In the absence of GRK-2 there appears to be an upregulation of compensatory inhibitory pathways that dampen signaling to protect neurons from overstimulation. This project will utilize cellular, biochemical and genetic approaches in a simple model organism to understand how cells respond to aberrant signaling; the findings will benefit researchers working in organisms ranging from yeast to humans. In particular, they will provide valuable information on the interconnectedness of signaling and regulatory pathways downstream of receptors. In addition, novel mechanisms used by cells to compensate for mis-regulated signaling may be revealed. Broader Impact Graduate students and undergraduates, including women and minority students, will participate in these studies. The University at Buffalo (UB) is a very diverse campus, providing a great opportunity to mentor minority students. Funds from this grant will support a summer stipend for an undergraduate from a Liberal Arts College that does not itself have undergraduate research. Providing early exposure to hypothesis-driven research is essential for preparing students for careers in the biological sciences. Students will present their findings at local (monthly), regional and international meetings. Importantly, the annual C. elegans meetings foster the development of junior scientists because many of the speakers are selected from graduate student submitted abstracts. Findings from this work will also be included in the lectures in an undergraduate Signal Transduction course at UB. Mutants obtained from the genetic screens in this project will be deposited at the Caenorhabditis Genetics Center, which will distribute them to any investigator that requests them. New gene and phenotype descriptions will also be incorporated into Wormbase, an online open access resource. Show more... | National Science Foundation | 7/17/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $533,041.00 | Grant | Trans-NSF Recovery Act Research Support The sense of taste is used by all organisms to determine whether potential food items will be ingested or rejected and is critical for the survival of the organism. The taste system is made up of multiple cell types that detect chemicals in food and then send a specific signal describing that stimulus to the brain. The goal of this project is to characterize a newly identified signaling pathway in taste cells that contributes to the detection of taste stimuli. Characterization of this signaling pathway will provide a better understanding of how the taste system works and how the brain gathers information about its surroundings. A combination of calcium imaging, molecular biology, and immunocytochemistry will be used to describe this newly identified signaling pathway and define its physiological role in the formation of taste signals that are sent to the brain. The findings that emerge from this project will improve the understanding of how taste receptor cells that are located on the tongue can detect chemicals in food and translate that information into a signal that the brain can understand. This information is critical for two reasons: 1) understanding how chemicals are detected from the environment has important implications in feeding behaviors including the regulation of food intake, and 2) information about the physiology of these neuronal cells will translate into a better understanding of how signaling pathways function in all neurons. This project will provide research and training opportunities for multiple graduate and undergraduate students, including both minorities and women. Students will be trained in molecular biology and immunocytochemical techniques as well as live cell calcium imaging on taste cells. These skills will provide students with the ability to answer research questions (either in the taste field or elsewhere) using a multi-faceted approach. Show more... | National Science Foundation | 6/01/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $57,583.00 | Grant | Trans-NIH Recovery Act Research Support Sepsis is a serious problem in surgical and trauma patients and the leading cause of death in critically ill patients. Many septic patients die of organ failure caused by microvascular dysfunction. Our long term goal is to elucidate the mechanisms by which microvascular dysfunction occurs in sepsis and can be prevented. We propose to evaluate a new theory wherein ascorbate acts on several therapeutic targets to modulate the gene expression that is the key to microvascular dysfunction. The specific hypothesis is that vitamin C prevents septic microvascular dysfunction by inhibiting NADPH oxidase and inducible nitric oxide synthase (iNOS) expression in endothelial cells. Specific Aim 1 is to identify the redox state of vitamin C that confers protection in sepsis. Vitamin C in its reduced state (ascorbate) can be reversibly oxidized to dehydroascorbic acid (DHAA). We will compare the effectiveness of ascorbate and DHAA for raising intracellular ascorbate and preventing microvascular dysfunction and mortality in polymicrobial sepsis. Mice with impaired ability to utilize ascorbate because of deficiency in the ascorbate transporter SVCT2 and wild-type controls (129S6 mice) will be subjected to the septic insult of cecal ligation and puncture (CLP) or will be sham operated. Subsequently the mice will be injected with vehicle or else with high or low doses of ascorbate or DHAA. Ascorbate concentrations in plasma and tissues, oxidative and nitrosative stress markers in plasma, functional responsiveness of arterioles, red blood cell flow in capillaries, and survival will be measured. Specific Aim 2 is to determine if vitamin C acts on NADPH oxidase and iNOS to prevent microvascular dysfunction in sepsis. Mice that are deficient in the NADPH oxidase subunit p47phox, deficient in iNOS, or are wild-type controls (C57BL/6 mice), will be compared. The mice will undergo CLP or sham operation, be injected with vitamin C or vehicle, and then expression of sepsis-associated genes in arterioles and endothelial cells, plasma coagulation, arteriolar responsiveness and capillary perfusion will be assessed. Specific Aim 3 is to elucidate the mechanisms by which vitamin C affects endothelial permeability, NADPH oxidase, iNOS and tissue factor in microvascular endothelial cells exposed to septic insult. The effects of septic insult, ascorbate and DHAA on intracellular ascorbate concentration and endothelial cell viability and permeability will be determined. Additionally, the signaling pathways through which vitamin C regulates NADPH oxidase, iNOS and tissue factor will be elucidated by comparing the responses of cells that are replete or deficient in p47phox, Nox catalytic subunits and iNOS. Accomplishing the specific aims will define the protective role of vitamin C during sepsis and provide the basis for its use as an adjunct therapy in septic patients.Project Narrative The significance of our research is that it addresses an important problem of direct clinical relevance. This research is innovative because it will determine the effects on sepsis-associated microvascular dysfunction and mortality of vitamin C injection. Our research is also original because it will elucidate in clinically relevant models of sepsis the intracellular signaling pathways by which vitamin C regulates endothelial cell gene expression Show more... | National Institutes of Health | 6/25/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $200,000.00 | Grant | Trans-NIH Recovery Act Research Support Pancreatic ductal adenocarcinoma is the fourth most common cause of cancer-related mortality in the United States, accounting for nearly 31,000 deaths each year. The vast majority of patients present with locally advanced or unresectable disease, and currently available conventional therapeutic approaches have been minimally successful in ameliorating the dismal prognosis of this malignancy. Nanobiotechnology provides unprecedented opportunities for addressing many of the current pitfalls in the diagnosis and therapy of pancreatic cancer. The current proposal represents a multi-institutional platform partnership between groups with extensive expertise in nanomaterial synthesis and delivery, pancreatic cancer biology, and small animal imaging. Multifunctional hybrid ceramic-polymeric nanoparticles, specifically indium phosphide quantum dots (InP Q-DOTS) and organically modified silica (ORMOSIL) nanoparticles have been developed for comprehensive preclinical evaluation in pancreatic cancer models. Specific Aim 1 of this proposal entails the synthesis of long-circulating (PEGylated), surface-functionalized Q-DOTS and dye-doped ORMOSIL nanoparticles incorporating PET probes ('nanoPET'), for improved imaging of early and metastatic pancreatic cancer in vivo. Specific Aim 2 of this proposal entails synthesis of long-circulating, surface-functionalized ORMOSIL nanoparticles encapsulating the small molecule inhibitor rapamycin (nanorapamycin) for systemic drug delivery to pancreatic cancer. A systematic approach is proposed, including an 'optimization' phase comprised of in vitro experiments using human pancreatic cancer cell lines and in vivo studies using conventional subcutaneous xenografts; these studies will then lead into an 'application' phase utilizing two preclinical models that faithfully recapitulate human pancreatic cancer biology, including the development of intra-abdominal metastases: first, a novel KRAS-driven transgenic mouse model of pancreatic cancer and second, a spontaneously metastasizing orthotopic xenograft model of human pancreatic cancer established in athymic mice. It is anticipated that clinical translation of these 'smart' nanomaterials will lead to improved staging of pancreatic cancer at diagnosis, early detection in 'at risk' individuals, and more potent therapeutic benefits for patients with advanced disease. The long-term goal of this proposal remains improvement in patient outcome for a malignancy with near-uniform lethality. Show more... | National Institutes of Health | 9/09/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $64,139.00 | Grant | Trans-NIH Recovery Act Research Support The overall goals of this project are to (A) obtain behavioral estimates of tinnitus induced by salicylate or noise exposure, (B) identify the changes in neural activity associated with salicylate or noise-induced tinnitus using MicroPET imaging and electrophysiological recordings and (C) determine if the behavioral, metabolic and neural manifestations of tinnitus can be suppressed by NS1883, a potassium channel agonist that appears to suppress salicylate-induced tinnitus. Spontaneous and sound evoked neural activity will be assessed in the auditory cortex and inferior colliculus of awake animals using 16-channel electrode arrays. MicroPET imaging combined with FDG tracer will be used to identify regions in the auditory pathway that show a significant change in metabolic activity during tinnitus. In Aim 1, the onset, recovery and pitch of tinnitus will be measured following treatment with a high dose of salicylate. Behavioral measures of tinnitus will be correlated with changes in metabolic activity and neural activity. We will determine if NS1883 can suppress the behavioral, neural and metabolic changes associated with salicylate-induced tinnitus. In Aim 2, the onset, time course and pitch of tinnitus will be assessed after high level noise exposure. Behavioral measures of noise-induced tinnitus will be correlated with changes in metabolic activity and neural activity. We will determine if NS1883 can suppress the behavioral, neural and metabolic changes associated with noise-induced tinnitus. This project will be the first to use MicroPET imaging to identify changes in metabolic activity in animal models of tinnitus. The project will significantly advance our understanding of the metabolic and neural changes in the auditory pathway that are associated with tinnitus, and will evaluate the effectiveness of a new potassium channel agonist in suppressing salicylate and noise-induced tinnitus. Show more... | National Institutes of Health | 7/17/2009 |
| CAMBRIDGE SQUARE OF HAMBURG, A LIMITED PARTNERSHIP | $519,300.00 | Grant |
Section 8 Housing Assistance Payments Program Special Allocations (Recover Rental Assistance Payments
There were 26 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Department of Housing and Urban Development | 3/16/2009 |
| LACKAWANNA MUNICIPAL HOUSING AUTHORITY | $1,459,353.00 | Grant | Public Housing Capital Fund Stimulus (Formula) Recovery Act Funded Conduct modernization activities at various Public Housing Developments. This funding can be expected to result in providing employment for architects and engineers, construction workers and product manufactures. In addition this funding can be expected to substantially modernize public housing units in this jurisdiction. Show more... | Department of Housing and Urban Development | 3/18/2009 |
| HEALTH RESEARCH, INC. | $386,285.00 | Grant | Trans-NIH Recovery Act Research Support Vitamin D has been investigated as a potential preventive therapy for prostate cancer (CaP) because of its many anti-cancer activities. We demonstrate in the transgenic adenocarcinoma of mouse prostate (TRAMP) model of CaP that early treatment with 1,25(OH)2D3 prevents hormone responsive CaP and is associated with decreased proliferation and increased differentiation. The in vivo response of TRAMP prostate to 1,25(OH)2D3 treatment indicates a decrease in cell cycle modulators that regulate G2/M transition and an increase in E-Cadherin, a marker of differentiation. 1,25(OH)2D3 had no preventative effect on castration recurrent CaP. We have identified a novel interaction of VDR with LSD1 and CoREST. LSD1 and CoREST are part of a recently described corepressor complex. LSD1 is a demethylase whose activity s associated with repression of gene transcription and increases in prostate cancer progression. Tranylcypromine (TCP) is a potent LSD1 inhibitor that can increase vitamin D mediated gene transcription. We propose a model in which LSD1 increases during prostate cancer progression and in castration recurrent disease, leading to interaction of VDR with LSD1 which represses VDR mediated gene transcription. The biological consequence of these changes is a loss of vitamin D¡¦s anti-cancer activity. Therefore, the effectiveness of 1,25(OH)2D3 can be enhanced by combination with LSD1 inhibitors. In this proposal, in Aim I we determine the molecular mediators of 1,25(OH)2D3 chemopreventive activity in vivo. In Aims II and III we test LSD1 as corepressor of vitamin D¡¦s action and test combination therapy of 1,25(OH)2D3 and a LSD1 inhibitor. Aim I. Determine the in vivo mechanism by which the chemopreventive action of 1,25(OH)2D3 decreases proliferation and increases differentiation in CaP. TRAMP animals are treated with 1,25(OH)2D3 starting at 4 weeks of age and expression of target molecules are examined by western analysis at multiple times during CaP progression. Cell cycle regulators being examined include: cyclin A, cyclin B1, cyclin E, skp2, cdk2, p27, p21, CDKN3, aurora-A, aurora-B, and Bub1. Modulators of differentiation being examined include: E-cadherin, ?Ò-catenin, Snail and LSD1. Aim II: Test the corepressor complex containing LSD1/CoREST as the molecular mechanism of deregulated VDR-mediated transcription in CaP cells that escape 1,25(OH)2D3¡¦s chemopreventive activity. The consequence of altering LSD1 activity by shRNA or chemical inhibition and by overexpression on VDR activity will be evaluated. Effect on vitamin D induced growth inhibition is measured by cell counts and MTT assay. Effects on gene expression is measured by qRT-PCR and luciferase reporter assays. Interactions of VDR with LSD1 and CoREST are evaluated by ChIP and Re-ChIP. Aim III: Determine if combination therapy of calcitriol and the LSD1 inhibitor, tranylcypromine (TCP), improves the chemopreventive effectiveness of vitamin D in hormone responsive and castration resistant CaP in an autochthonous model of CaP (TRAMP). TRAMP animals will be treated with 1,25(OH)2D3 alone, TCP alone and 1,25(OH)2D3 in combination with TCP. The impact on hormone responsive, castration recurrent disease and time to palpable tumor will be evaluated. The studies in the proposal will identify the mechanism of vitamin D¡¦s chemopreventive activity in vivo, establish LSD1 as a corepressor for the vitamin D receptor, and test combination therapy of 1,25(OH)2D3 with LSD1 inhibitors to improve the effectiveness of vitamin D¡¦s chemopreventive activity. Thus, these studies are fully translational. The rationale for these studies is that an understanding of the mechanism of action of vitamin D chemopreventive activity at the molecular level provides the basis for developing improved therapeutics and identifying patients most/least likely to benefit from vitamin D therapy. Show more... | National Institutes of Health | 7/16/2009 |
| STATE UNIVERSITY OF NEW YORK | $352,813.00 | Grant | FEDERAL WORK-STUDY PROGRAM Federal Work-Study provides need-based financial a | Department of Education | 7/01/2009 |
| CANISIUS COLLEGE OF BUFFALO | $139,714.00 | Grant | FEDERAL WORK-STUDY PROGRAM Federal Work Study provides need based financial a | Department of Education | 7/01/2009 |
| DAEMEN COLLEGE | $43,280.00 | Grant | FEDERAL WORK-STUDY PROGRAM Federal Work-Study provides need based financial a | Department of Education | 7/01/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $394,857.00 | Grant | Trans-NIH Recovery Act Research Support Varicella zoster virus (VZV) is the causative agent of chicken pox and shingles. The overall objective of this proposal is to understand the nature of physical and functional interactions between the complex VZV major transactivator, IE62, and specific components of the cellular transcription apparatus. Such information is critical to our understanding of the complex pathogenesis of VZV infection. It is particularly important in terms of the live attenuated VZV vaccine. Vaccination is now recommended for all children and recently the FDA approved the vaccine for use in the elderly for the prevention of zoster based on an extensive clinical trial. Currently little is known concerning attenuation of the vaccine virus. Since the IE62 gene accumulates the majority of mutations in the attenuated vaccine strains, understanding its interaction with host functions could lead to the development of second generation vaccine whose molecular mechanism of attenuation is well understood. The work proposed involves three Specific Aims. Specific Aim 1: Functional Interaction of IE62 with Cellular Factors. We will examine the functional interaction between the IE62 protein and two essential cellular transcription factors the Mediator complex and HCF-1. This will be done by mapping and mutation of interacting domains and expression of these mutations in the context of the viral genome. Specific Aim 2: Role of DNA Binding in the Mechanism of IE62 Activation. We will determine the specificity and affinity of the IE62- DNA Interaction and the effect of mutations in the DNA-binding domain on IE62 DNA-binding and transactivation and viral gene expression. Specific Aim 3: Interrelationship Between IE62 Structure and Function. We will mutate the IE62 SEAC domains and assess there function in in vitro transcription assays. The growth properties of virus carrying mutations in these domains will be determined. We will determine if the two transcriptional activation domains present in the IE62 homodimer are both required for IE62 function and what functions they perform. These studies will help us to understand the ways in which this important viral protein influences the functions of cells following infection. Since the live attenuated VZV vaccine will be used to prevent chicken pox and shingles throughout the U.S. population it is important to understand how the virus interacts with its human host. This work should also result in information that could be used in strategies to develop better anti-viral drugs and vaccines. Show more... | National Institutes of Health | 9/16/2009 |
| CLEVELAND BIOLABS, INC. | $458,512.00 | Grant | Trans-NIH Recovery Act Research Support To develop a medical radiation countermeasure to meet the radiological and nuclear threats in support of the preparedness mission and priorities of the HHS Puclic Health Emergency Medical Countermeasures Enterprise (PHEMCE) as articulated in the PHEMCE Implementation Plan for CBRN threats. (page 3) Show more... | National Institutes of Health | 9/21/2009 |
| HEALTH RESEARCH, INC. | $1,300,294.00 | Grant | Trans-NIH Recovery Act Research Support The Roswell Park Cancer Institute (RPCI) has been continuously recognized as a Comprehensive Cancer Center since the NCI designation of such centers in 1974 and is now requesting continued federal support for the next five years. A free-standing research, education and clinical cancer care Institute, RPCI occupies a 27 acre campus near downtown Buffalo and has expanded to nearly 1.6M gsf of clinical and research space, a 16% increase since the last review period. RPCI serves a population base of ~1.5M in Western New York where the RPCI tumor registry is recording more than 3,400 new cancer patients per year. RPCI has strong collaborations with the University of Buffalo and the Hauptman-Woodward Institute for Structural Biology, but is a fully independent entity with Dr. Donald Trump, CCSG PI and RPCI President/CEO, answering only to the RPCI Board of Directors. Since the last competitive renewal, the RPCI has grown significantly as demonstrated by: 1) the recruitment of over 100 new faculty clinicians and researchers of which 43 are new CCSG members; 2) a 74% increase in total NCI funding and a 44% increase in total peer-reviewed funding; 3) a 73% increase in accrual to investigator-initiated, interventional clinical trials and a 44% increase to accrual in all interventional trials; 4) the addition of 4 new shared resources with an institutional investment of over $2.0 M and (5) the opening of a new, 177,000 gsf, state-of-the-art research building housing Program member laboratories and Shared Resources. With the growth in faculty has also come the recruitment of three Senior Leaders. In addition, a director for the newly created RPCI Office of Cancer Health Disparities Research has also been recruited. As part of the scientific growth within RPCI, a new disease-specific Research Program, the Prostate Program, has been added in this renewal bringing RPCI to a total of six Scientific Programs that also include Cancer Prevention & Population Sciences, Cell Stress & Biophysical Therapies, Genetics, Molecular Targets & Experimental Therapeutics and Tumor Immunology & Immunotherapy. With strong leadership and institutional commitment, RPCI will continue to focus on recruiting talented investigators to further expand research efforts targeting areas in genetics, investigational imaging and cancer health disparities. Show more... | National Institutes of Health | 9/22/2009 |
| LANCASTER TOWERS ASSOCIATES, L.P. | $93,368.00 | Grant | Section 8 Housing Assistance Payments Program Special Allocations (Recover a portion of the Sec 8 funding was provided by ARR | Department of Housing and Urban Development | 3/16/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $1,364,448.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Rural Are
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 6/18/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $200,000.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 4/08/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $261,041.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 5/26/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $240,000.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 5/26/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $1,352,529.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 4/29/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $763,880.00 | Grant | Trans-NIH Recovery Act Research Support Myotonic muscular dystrophy type 1 (DM1) and type 2 (DM2) are caused by a toxic gain of function by expanded repeating RNAs. Both expanded repeats reside in noncoding regions and bind to the splicing regulator muscleblind (MBNL1); the formation of the RNA-protein complexes causes DM by inactivating MBNL1. Our group has developed a series of modularly assembled, multivalent ligands that specifically bind the DM RNAs with nanomolar affinities and that potently inhibit the formation of the DM RNA-MBNL1 complex in vitro with nanomolar IC50's. These compounds are also permeable to mouse myoblasts when simply added to the culture medium; a subset of the ligands localize to the nucleus, which is where the RNA-MBNL1 interaction occurs in vivo. Because these compounds are high affinity, specific, and cell permeable, they have the potential to be biologically active. Our aims are two-fold: determine the efficacy of modularly assembled, multivalent compounds that target the DM1 repeats in cell culture and to understand the molecular recognition of the RNA-ligand complexes using X-ray crystallography in order to design more potent and selective inhibitors. If successful, these investigations may result in the development of a general strategy to design compounds that target toxic triplet repeating RNAs. Specifically, we propose to: 1. Optimize previously identified, multivalent ligands a.) to disrupt the formation of the DM1 RNA- MBNL1 interaction and to specifically bind the DM1 RNA in vitro and b.) for improved uptake, cellular localization, and toxicity profiles in a mouse myoblast cell line and DM1-affected myoblasts. Ligands identified to bind the DM1 RNA were multivalently displayed on a peptoid backbone. In the proposed studies, the spacing modules between ligands will be changed to optimize inhibition potency and to alter cellular uptake and localization properties. 2. Determine if a series of lead compounds that meet the criteria in Specific Aim 1 can increase translation of rCUG-repeat containing RNAs using a luciferase reporter system, disrupt nuclear foci in DM1-affected myoblasts using a fluorescence in situ hybridization (FISH) assay, and correct splicing defects (insulin receptor) that are associated with DM1 using RT-PCR. 3. Determine the structure of DM 1 and DM2 RNAs in the presence of ligand. Such studies will identify the features of the small molecule that are important for binding the RNA. Derivatives can then be made to improve affinity and specificity. We expect that the proposed work will stimulate the economy by enabling hiring of additional scientific staff, consistent with the goals of Notice Number NOT-09-058, NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications. PUBLIC HEALTH RELEVANCE: Myotonic dystrophy (DM) is a genetic disease characterized by wasting of muscle function including organ wasting that leads to cardiac disease, respiratory impairment, cataracts, and a host of other significant problems. At present, there are no therapeutics that treat the cause of DM, the formation of an RNA-protein complex. In this proposal, we describe the determining the biological efficacy of previously developed small molecules to move towards the development of DM therapies and the structural determination of RNA-ligand complexes to design more potent and specific compounds. Show more... | National Institutes of Health | 9/30/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $100,000.00 | Grant | Trans-NIH Recovery Act Research Support The solution and redox properties of iron that make it the metal prosthetic group of choice for the activation of otherwise kinetically inert substrates, including dioxygen, also make ionic Fe cytotoxic to aerobic organisms. Eukaryotes from yeast to humans have to manage ferrous iron's inherent reactivity with dioxygen and ferric iron's instability in water; the oft-cited role of iron in human pathology from post-ischemic tissue damage to neurodegenerative disease is testament to the importance of managing ionic iron. We propose that the Fe-traffieking pathway that succeeds in suppressing Fe's abiologic side-reactions has two essential and inter-related features: sequential Fe-trafficking components are spatially contiguous and thereby are architecturally organized to support the channeling of ionic Fe species along the Fe-metabolic pathway. This model will be tested at three steps in the ionic Fe pathway in Saccaromyces cerevisiae, the most tractable eukaryotic cell for a systematic test of this Fe-metabolic model. These three steps are: at the plasma membrane where ferrireduction is coupled to iron permeation; in the cytoplasm where Fe is trafficked from the PM to protein acceptor sites; and in the vacuole where Fe-redox cycling is coupled to Fe-storage in reactions that precisely mirror those that occur in ferritin. A primary strategy to ascertain conformational contiguity of Fe-handling proteins will be fluorescence resonance energy transfer; we propose to use FRET to examine the spatial relationships between reductase and permease partners in the plasma and vacuolar membranes. A primary strategy in quantifying the relative partitioning of newly-arrived Fe will be the use of cells engineered to turn on or turn off production of these putative Fe-handling proteins. A new role in Fe- handling is proposed for the yeast HSP90 proteins, Hsp82 and Hsc82; in addition, we suggest that nitric oxide and glutathione combine in a dinitrosyldithiolato-Fe complex that plays a significant role in cytoplasmic Fe-handling. Outstanding progress has been made on the metabolism of Fe-prosthetic groups like heme and Fe/S clusters; ionic Fe is the precursor to these 'caged' Fe-species and is responsible for the 'corrosive chemistry' that characterizes the relationship between Fe and dioxygen. An understanding of how cells suppress this chemistry would make a significant contribution to our eventual elucidation of the molecular basis for the multitude of human pathologies often attributed in part to mismanaged ionic iron. Show more... | National Institutes of Health | 9/22/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $25,836.00 | Grant | Trans-NIH Recovery Act Research Support Although there is a long history of research on basic cognitive and motivational processes in ADHD and a long history of research on effective treatments for ADHD, there is almost a total absence of research relating basic processes to the impact of clinical interventions. Contemporary theories of ADHD emphasize a range of basic cognitive processes, including inhibitory control, working memory, and sustained attention, and basic motivational processes such as delay-related impulsivity (a tendency to choose small, immediate rewards over larger, delayed rewards). An important, yet untested, corollary of these models is that the primary treatments for ADHD - stimulants such as methylphenidate (MPH), behavioral treatment, and their combination - exert their effects by improving these basic processes. Thus, there are important gaps in our understanding of the extent to which the basic processes are sensitive to each of these treatments, and there are almost no data to address whether changes in basic cognitive and motivational processes actually account for treatment effects in clinical settings. The proposed research fills these gaps. First, it is the first study to concurrently examine the effects of both MPH and performance-based motivational incentives (i.e., monetary rewards, an analogue of behavioral treatment) on laboratory measures of inhibitory control, working memory, sustained attention, and delay-related impulsivity in children with ADHD (n=108). A group of age- and gender-matched controls (n=108) is included for comparison but not given MPH. We hypothesize that children with ADHD will exhibit impaired performance in the absence of motivational incentives, but that this pattern will be ameliorated in the presence of incentives for good performance. Second, among the children with ADHD, incentive will be crossed with doses of extended-release MPH (placebo, O.3., and 0.6 mg/kg) on a within-subjects basis to provide an initial examination of the separate and interactive effects of these analogue treatments on neurocognitive processing. Third, the proposed research will be the first to test the extent to which MPH effects on basic processes assessed in the lab actually mediate, or account for, individual differences in clinical response to MPH. To accomplish this aim, the participants with ADHD will undergo a 3-week, double blind school-based medication assessment to examine MPH effects on ADHD children's functioning in a natural setting. Thus, the proposed research will bridge basic and clinical research in ADHD and will provide critical initial tests of the hypothesis that changes in basic cognitive and motivational processes are the mechanisms by which treatments for ADHD work. This work will pave the way for a new generation of translational research and theory in ADHD. Show more... | National Institutes of Health | 6/01/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $128,297.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 4/29/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $447,857.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 4/29/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $900,000.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 4/29/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $1,249,919.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Rural Are
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 3/19/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $1,221,901.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 5/26/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $1,410,000.00 | Grant | Highway Planning Highway Infrastructure Investment Grant: Areas wit | Federal Highway Administration | 7/30/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $570,000.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 3 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 7/01/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $380,000.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 5/26/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $499,995.00 | Grant | Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area (04) Clinical Research and specific Challenge Topic, 04- AA-103: Novel Models of Service Delivery. Nearly 1 in 20 adult women in the U.S. are married to or living with an alcoholic or problem drinking partner. As a result, these individuals experience significant psychological and physical distress, utilize health care services to a greater degree than spouses of nonalcoholics, and incur overall higher healthcare costs. While their physical and psychological health is important in its own right, their health and coping skills also can play a significant role in facilitating alcoholic partner drinking reduction and help-seeking, and in buffering their children from the negative effects of the other parent's alcohol problem. Yet, despite its size, distress, and importance, this population remains largely hidden and underserved. Relatively few of their partners seek treatment, and psychological and socioeconomic barriers limit the availability of and access to empirically- tested services for themselves. These barriers include: (a) inadequate third party coverage, (b) inability to pay, (c) fear of stigmatization, (d) fear of the partner's reaction, (e) competing job, childcare and other demands, (f) geographical and other isolation, and (g) the fear that they will be told to leave the partner, which they are not willing to do. The self-help group Al-Anon is available to this group, but not widely used, and its efficacy unclear. Stage II efficacy trials now show that clinic-based cognitive-behavioral, coping skill-based interventions, designed specifically for the spouse of the alcoholic can be effective in reducing psychological distress or facilitating alcoholic-partner help-seeking or drinking reduction, but the access barriers remain the same. Unless alternate service delivery models are developed, these treatments will reach relatively few individuals, and have little public health impact. The challenge is to develop novel, alternate service delivery models for these empirically-supported interventions that provide secure, engaging, low cost, easy access to a much larger population of women with alcoholic partners than the small population currently served. To begin to address this service delivery challenge, the current Stage I treatment development application proposes to build on the investigators' substantial research on face-to-face Coping Skills Training (CST) for women with alcoholic partners by adapting CST to a World Wide Web-accessible or deliverable database. An internet-delivered CST model has the potential to address several of the barriers noted above by providing services that (a) are relatively low cost, (b) readily accessible to a very broad population of women with alcoholic partners, (c) are accessible 24/7, and (d) with appropriate security precautions, offer a higher degree of privacy than clinic-based treatment, thereby helping to reduce stigma, embarrassment and other concerns. Development and preliminary evaluation of the internet-based CST (iCST) in the current proposal is accomplished in the two substages of Stage I treatment development work. In Stage Ia, we follow an iterative, user-centered Web site development process to adapt the content of the previously developed, face-to-face CST for interactive, on-line delivery. In Stage Ib, we pilot the feasibility of recruiting women for an iCST clinical trial, and randomly assign 84 women with a partner with an active alcohol use disorder to either 8 weeks of iCST or 8 weeks of a delayed treatment control (DTC) condition. The complete abstract for this award is available at http://report.nih.gov/recovery/ Show more... | National Institutes of Health | 9/22/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $74,743.00 | Grant | Trans-NIH Recovery Act Research Support The overall objective of the proposed experiments is to examine the behavioral abilities of mice to hear in several listening situations. We will test the detection of simple sounds in quiet, the monaural temporal resolution acuity, and binaural sound localization accuracy. Once reliable behavioral paradigms are established for normal mice, these same measures will be taken on mice lacking the voltage-gated potassium channel subunit Kv1.1. Both in vivo and in vitro physiological studies on these Kcna1 knockout mice suggest that these animals should have normal hearing capabilities for detecting pure tones in quiet, but should have poor temporal resolution. Whether this temporal resolution will manifest itself in both monaural and binaural temporal processing situations is unknown, so both will be measured. Although physiological studies comparing knockouts to wild-type mice are important, they do not tell us how the whole, awake, behaving animal is affected. The experiments proposed here will reveal any type of deficit that may be seen in mice lacking a completely normally-functioning auditory system. These experiments will establish a reliable method for testing auditory behavior in mice that can be used for both normal subjects and for those with abnormal auditory functioning. Mice lacking the gene Kcna1, a mutation linked to epilepsy, stress-induced ataxia, and chronic muscle twitching in humans, show abnormal physiological responses to auditory stimuli. It is unknown, however, how this affects the 'real world' listening situation of these animals, so this will be determined here. Show more... | National Institutes of Health | 8/14/2009 |
| TONAWANDA, TOWN OF | $505,121.00 | Grant |
Community Development Block Grant ARRA Entitlement Grants (CDBG-R)(Recover The Community Development Block Grant Program enables local governments to undertake a wide range of activities intended to create suitable living environments, provide decent affordable housing and create economic opportunities, primarily for persons of low and moderate income. Under the Recovery Act, the Town of Tonawanda has given priority to projects that can award contracts based on bids within 120 days of the grant agreement. Three of the five projects that the Town originally planned on for CDBG-R have been substantially completed. The other two projects will be completed within the next 2 quarters. The projects that are near completion have provided employment for 34 persons and have taken another step to ensuring a more suitable living environment for all Town residents. Show more...
There were 3 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Department of Housing and Urban Development | 8/13/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $600,000.00 | Grant | Trans-NSF Recovery Act Research Support Technical Summary Vanadium oxides have a rich and complex phase diagram originating from the facile accessibility of different vanadium oxidation states and the various structural distortions adopted to accommodate non-stoichiometry and point defects. The proposed research project focuses on understanding the influence of finite size on the properties of two intriguing vanadium oxides, VO2 and V2O5. Bulk VO2 shows a dramatic insulator?metal phase transition at ~67??C and represents a textbook problem in solid-state chemistry and physics. The proposed work is inspired by our preliminary results showing a strong size dependence of the phase-transition temperature and hysteresis for VO2 nanostructures prepared by hydrothermal methods. Chemical vapor deposition and hydrothermal approaches for the fabrication of VO2 nanostructures with controlled shape, size, and growth direction will be explored. A systematic investigation of the crystal growth mechanism will be performed to obtain rational and predictive control over the nanostructure dimensions. A combination of ensemble X-ray absorption spectroscopy, Raman spectroscopy, and X-ray diffraction measurements will be used in conjunction with single-nanowire electrical transport and Raman spectroscopy measurements to understand the influence of finite size on the insulator?metal phase transition in these nanostructures. Another aspect of the proposed CAREER proposal will involve the fabrication of V2O5 nanowires and their dielectrophoretic integration within device structures. Simultaneous electrical conductivity and Raman spectroscopy measurements of single nanowires will be performed within device geometries to understand the influence of finite size in modifying the electrical transport and surface conductance of these nanowires in the presence of alcohol vapors. The synthesis and device integration of anisotropic VO2 and V2O5 nanostructures will pave the way for their implementation in optical switching devices, thermochromic coatings, Mott field-effect transistors, alcohol sensors, and waveguides. Non-Technical Summary Nanoscale materials often show properties that are not exhibited by their bulk counterparts. The proposed research effort is focused on understanding how such properties can be harnessed for practical applications such as making faster electronic circuits for use in the next generation of computers, ?smart? window materials that change color with temperature, and accurate sensors for detecting low concentrations of vapors. Vanadium dioxide, one of the materials that will be explored in this project, is a transparent insulator at room temperature but upon heating to 67??C becomes an excellent conductor that is almost completely opaque. The proposed research will focus on shifting this transition closer to room temperature wherein this dramatic effect can be used to construct ultrafast nanoelectronic circuits and temperature-sensitive coatings. An integrated outreach and education program is also proposed emphasizing teacher professional development, classroom engagement, and curricular reform at the middle-school level at a local urban high-needs school. These activities will serve to build sustained mentoring relationships between faculty, graduate students, undergraduate students, and middle-school teachers and students. This effort will seek to actively engage Buffalo Public School middle-school students from economically disadvantaged backgrounds in appreciating science and technology at a critical and formative time period. The collaborative development of attractive curricular material and challenging laboratory experiments along with sustained classroom visitation and after-school science activities will form the cornerstone of this program. A freshman seminar course will be developed to discuss the broader societal implications of nanotechnology. Show more... | National Science Foundation | 5/27/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $211,688.00 | Grant | Trans-NSF Recovery Act Research Support Collaborative Research: Do CFCs and SF6 behave as reactive (sorbing) tracers in low carbon content sedimentary aquifers? This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). Intellectual Merit: CFCs and SF6 are environmental tracers used to date recent groundwater (up to ~50 years). Because these compounds are relatively soluble, the current paradigm expects conservative (no sorption or degradation) transport of these compounds in aerobic, low carbon content (foc) aquifers. We posit that CFCs and SF6 act as reactive (sorbing) tracers in many low foc sedimentary aquifers ? in particular those that contain thermally altered carbonaceous matter (TACM). TACM examples include char, coal and kerogen. TACM occurs commonly in sediments deposited since the Devonian. Our preliminary experiments demonstrate that CFC sorption is sufficient to significantly retard CFC transport in low foc aquifers. This project will provide the first systematic assessment of the impact of different forms of TACM on CFC and SF6 sorption. The experiments will be completed for selected low foc sediments over an unprecedented concentration range of ~9 orders of magnitude. CM will be fractionated, quantified and classified using established methods. The isotherm models and parameters deduced will be used to evaluate the conditions in which significant retardation of these solutes are expected in low foc aquifers. Broader Impacts: The proposed project will provide support for a new collaboration between Drs. Allen-King and Sheldon, faculty members at neighboring and complementary SUNY institutions: Geneseo, a primarily undergraduate institution, and Buffalo, a PhD granting institution. This project will enhance educational opportunities through direct support of four undergraduate students and one PhD student. It will provide opportunities to develop connections through student exchanges between the institutions. The PIs will invite applications from qualified students with particular attention to soliciting participation from members of underrepresented groups. Benefit to society from this project will come through improved understanding of the reactive transport of moderately hydrophobic chemicals in groundwater and improved groundwater age estimates. This project will support economic stimulus through providing well paid positions for research students and valuable training that will enhance their technical contributions as they enter the workforce Show more... | National Science Foundation | 7/09/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $524,049.00 | Grant | Trans-NSF Recovery Act Research Support The State University of New York at Buffalo has received a grant to create a database and software tools to facilitate the study of gene regulation, through transcriptional cis-regulatory modules (CRMs). CRMs are a major class of genomic sequence elements required for the temporal and spatial control of gene expression. CRMs play critical roles with respect to normal phenotypic variation, birth defects, chronic diseases, and evolution. Despite this clear importance of CRMs for many areas of biology, our knowledge of these sequences is surprisingly limited. CRMs are vastly underrepresented in current genome annotations, in part because most CRMs are uncharacterized, but also because there has been little effort to curate the literature for known CRMs or to develop appropriate databases to house CRM information. This project, by producing a well-annotated collection of known CRMs, will be of significant use in a number of important areas, including studies of transcriptional regulation, of the evolution of CRMs and new gene functions, and of genome structure. The project also provides training data for computational approaches to CRM discovery, leading to improved methods for identifying uncharacterized CRMs. The project has constructed the first database of known CRMs for any animal, the REDfly (Regulatory Element Database for Fly) database of regulatory elements for the fruit fly Drosophila melanogaster. Funding under this award is allowing for the continued development and expansion of REDfly into a fully comprehensive resource for Drosophila and for its extension to regulatory elements from vertebrate model organisms, including the zebrafish and mouse. Analysis of the REDfly data will lead to the discovery of new important features of CRMs and to the generation of exciting new hypotheses about gene regulation that are being tested experimentally in the laboratory. REDfly also serves as a useful resource for education and training in genomics, gene regulation, and genome annotation at the graduate, undergraduate, and secondary school levels through a variety of courses, workshops, and informal training activities. These activities create in REDfly a comprehensive repository for cis-regulatory sequence and expression pattern data for three major metazoan model organisms, making REDfly the most powerful available resource for large-scale studies of the composition, organization, and evolution of transcriptional cis-regulatory elements. The REDfly database can be found at http://redfly.ccr.buffalo.edu. Show more... | National Science Foundation | 7/18/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $2,383,814.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 3/30/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $7,960,000.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 3 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 4/29/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $3,819,200.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 3 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 4/29/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $3,051,114.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 4/29/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $900,000.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 4/29/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $209,379.00 | Grant | Trans-NSF Recovery Act Research Support Rapid changes in the arctic climate system that occurred in the relatively recent past can be compared with the output of climate models to improve the understanding of the processes responsible for nonlinear system change. This study focuses on the transition between the Holocene thermal maximum (HTM) and the onset of Neoglaciation, and on the step-like changes that occurred subsequently during the late Holocene. The millennial-scale cooling trend that followed the HTM coincides with the decrease in Northern Hemisphere summer insolation driven by slow changes in Earth's orbit. Despite the nearly linear forcing, the transition from the HTM to the Little Ice Age (1500-1900 AD) was neither gradual nor uniform. To understand how feedbacks and perturbations result in rapid changes, a geographically distributed network of proxy climate records will be used to study the spatial and temporal patterns of change, and to quantify the magnitude of change during these transitions. The researchers of this collaborative project will use lacustrine sediments to produce 13 new high-resolution proxy climate records of the past 8000 years. The study sites form two focus regions (eastern Beringia and the NW Atlantic) that generally coincide with the nodes of the surface temperature expression of the Arctic Oscillation (AO). This effort will nearly double the number of high-resolution lacustrine records that extend through the last two millennia, and will generate some of the first high resolution records that capture the HTM. During the HTM, summer sea-ice cover over the Arctic Ocean was likely the smallest of the present interglacial period; certainly it was less extensive than at any time in the past 100 years, and therefore affords an opportunity to investigate a period of warmth similar to what is projected during the coming century. This study focuses on lakes because lakes are the most widely distributed sources of proxy climate records that consistently extend through the post-glacial interval. Because climate change is amplified in the Arctic, the climate signal preserved in arctic lake sediments should be stronger than elsewhere. The proxy records generated in this project will use conventional and newly emerging techniques to document the spatio-temporal patterns of abrupt environmental changes, and to derive quantitative estimates of past summer temperature and hydroclimate variables. Most lakes have been cored previously and show potential for generating high-quality proxy records. Five of the lakes contain laminated sediment with annually resolved records; others have high sedimentation rates (>0.5 mm yr-1) for sub-decadal resolution across the climate transitions. Confidence in the paleoclimate reconstructions will be bolstered by a multi-proxy approach, and by replicate lake records in each of the focus regions that will be used to distinguish basin-scale thresholds from regional-scale climate shifts. This project builds on on-going climate-modeling experiments that use NCAR's Climate System Model (CCSM3) to study the sensitivities of the arctic system to volcanism and solar variability. A new data-model comparison proposed for this study will test whether the most prominent changes in the arctic system during the past 8 ka, as reconstructed from the proxy records, can be explained by a plausible combination of system-component conditions coincident with prolonged volcanism. The experiments, conducted with NCAR collaborators, will focus on the elements of the Arctic system (e.g., AO and extent of sea ice) that participate in abrupt transitions, and that might elicit nonlinear changes in the future. Show more... | National Science Foundation | 7/23/2009 |
| ERIE, COUNTY OF | $878,421.00 | Grant |
Community Development Block Grant ARRA Entitlement Grants (CDBG-R)(Recover 9 Community Development Projects funded for a total of $878,421. The projects will help to stimulate the economy through the provision of needed infrastructure improvements in low to moderate income neighborhoods. The infrastructure improvements include waterline replacement and installation, road reconstruction, sidewalk replacement and environmental remediation of a former waste water facility. The projects will help to create approximately 162 jobs during the construction phase. The projects will also promote energy efficiency by replacing older deteriorated infrastructure with new water, drainage and road improvements. Show more...
There were 9 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Department of Housing and Urban Development | 8/10/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $121,690.00 | Grant | Trans-NSF Recovery Act Research Support This proposal is aimed at breaking the convexity bounds for $L$-functions on high rank groups. The principal investigator has already made the first progress on breaking the convexity bounds for self dual L-functions on GL(3). The problems related to breaking the convexity bounds for L-functions on high rank groups in various aspects are discussed in the proposal. Concrete conjectures are made, possible difficulties are discussed, new techniques and tools are mentioned. These projects are closely related to one of the most fundamental open problems in number theory - the Lindeloff hypothesis for degree n L-functions. The subconvexity bounds are the first steps toward the Lindeloff hypothesis. The proposal is concerned with the study of the size of certain number theoretical functions (infinite sums with one complex parameter) which are constructed on some geometric spaces. Bounding such functions are important not only because of its theoretical value but also because of its vast applications. For example, one application would be a stronger quantum unique ergodicity conjecture which tells us the convergence of certain measures on certain geometric spaces as well as the rate of convergence of these measures. This is a very important problem in mathematical physics. Other applications will be found in the future. Show more... | National Science Foundation | 6/16/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $277,375.00 | Grant | Trans-NIH Recovery Act Research Support This project investigates 'impulsivity' as a predisposing factor for drug abuse. Drug abuse researchers have extensively studied 'reward-related' factors that facilitate drug-seeking behaviors, including both unconditioned and conditioned positive affective responses to drugs while ignoring 'impulsivity-related' processes that normally inhibit or limit the use of drugs. We believe that processes related to impulsivity may be as important as reward processes in determining whether an individual will use drugs. One reason for the lack of attention to 'impulsivity related' factors may be the lack of adequate laboratory models. The primary objective of the proposed research is to develop and use laboratory-based, behavioral measures of impulsivity to study the relationship between impulsive processes and drug abuse. Our own research as well as other recent findings indicates that 'impulsivity' does not refer to a single process or trait. Instead, several distinct behavioral processes appear to underlie the broad category of 'impulsive behaviors'. One process that can result in impulsive behaviors is the preference for smaller, more immediate rewards over larger delayed rewards, and it is measured using the delay discounting task. A second process corresponds to the inability to inhibit (stop) a prepotent response. This is referred to as behavioral inhibition and is measured using the Stop Task. We have identified a new, third process, which relates to attention. Impairments in attention have not been studied extensively in relation to drug abuse; sustained attention is likely to be important for self-control, particularly during periods of abstinence from drug taking behaviors. The proposed project will use non-human laboratory models of impulsivity to determine the strength of association between cocaine self-administration and impulsivity as measured by delay discounting and sustained attention tasks. A self-administration (SA) procedure which includes acquisition of drug taking, escalation of drug intake, extinction of drug taking, and finally cue-induced reinstatement of drug taking, which models important features of human drug use will be used. We have previously accumulated promising data on these tasks, and the proposed studies will provide important information validating the role of specific types of impulsive behaviors in drug abuse. The proposed studies will provide important new information concerning putative animal models of impulsivity, and the ability of these models to predict cocaine self-administration. Show more... | National Institutes of Health | 7/16/2009 |
| TONAWANDA, TOWN OF (INC) | $544,700.00 | Grant | ENERGY EFF AND CNSRVTN BLOCK GRANT PGM The Town of Tonawanda, NY will install photovoltaic panels on the roofs of five municipally owned buildings thereby reducing the Town's consumption of fossil fuel generated electricity. The reduction in electricity usage will limit the Town’s dependence on fossil-fuel driven electrical generation, thus limiting its contribution toward greenhouse gas emissions. The photovoltaic systems to be installed on the five municipally owned buildings will reduce green house gas emissions by 2,771 tons of CO2 over the next twenty-five years (estimated life span of the photovoltaic panels). The photovoltaic system will reduce utility costs paid by the Town and its tax base, freeing up resources for future parallel energy improvements. The Town estimates saving $802,800 in utility costs over the 25 year life of the system. The Town anticipates using monies saved to invest in additional photovoltaic systems to be installed on other Town owned facilities in the future. Following is a breakdown of the activity components: Tonawanda Highway Department located at 450 Woodward Avenue, Kenmore NY 14217 - 96 photovoltaic panels will be installed resulting in reduced green house gas emissions by 16.2 tons annually and a utility savings of $5,280.00 annually. Tonawanda Police Department located at 1835 Sheridan Drive, Tonawanda NY 14223 - 120 photovoltaic panels will be installed resulting in reduced green house gas emissions by 19 tons annually and a utility savings of $6,168.00 annually. Tonawanda Sewer Maintenance Building located at 525 Belmont Avenue, Tonawanda NY 14223 - 238 photovoltaic panels will be installed resulting in reduced green house emissions by 38.5 tons annually and a utility savings of $10,476.00 annually. Tonawanda Water Treatment Plant located at 218 Aqua Lane, Tonawanda NY 14223 - 120 photovoltaic panels will be installed resulting in reduced green house emissions by 18.5 tons annually and a utility savings of $5,040.00 annually. Tonawanda Waste Water Treatment Facility located at 750 Two Mile Creek Road (mailing address 779 Town Mile Creek Road) Tonawanda, NY 14150 - 120 photovoltaic panels will be installed resulting in reduced green house gas emissions by 19 tons annually and a utility savings of $5,148.00 annually. The project is estimated to create/retain ten jobs. The total project cost is estimated to be $910,876 including $544,700 in EECBG funds and $366,176 in leveraged funds. Show more... | Department of Energy | 9/11/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $525,000.00 | Grant | Trans-NSF Recovery Act Research Support Technical Abstract This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Faculty Early Career Award funds a proposal that seeks to make significant impact on our current understanding of the physics of quantum phase transitions (QPT) in superconducting nanostructures. Nanometer scale indium oxide devices with precisely engineered structural and transport characteristics will be utilized to probe the subtle interplay between disorder and interaction across the superconductor-insulator QPT. These experiments will provide explicit information about the microscopic conduction mechanisms when the transition is tuned via disorder, density or magnetic field in one and two-dimensional devices. The results will improve our current understanding of the phase coherence and emergence of novel collective phases near quantum critical points. Research is closely integrated with the education component of the proposal: an undergraduate laboratory experiment to explore quantum nature of electrons will be developed and hands-on research opportunities will be provided to a broader group including high school science teachers in the Buffalo region. The education plan also seeks to improve the learning experience of students in undergraduate introductory physics courses through a variety of modern teaching methods. Non-technical Abstract: This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). The goal of this Faculty Early Career Award is to effectively combine experimental research to explore quantum phases near critical points in superconducting nanostructures with education and outreach programs to train a new generation of undergraduate and graduate students and high school teachers. The research proposal will seek an unprecedented control in engineering the microstructure and property of the material used (indium oxide) and the transport measurements in nanodevices proposed herein are expected to transform our current understanding of quantum phases in one and two-dimensional systems. The integrated educational aspects will involve several projects closely related to the research activities in the PIs group. A new undergraduate laboratory experiment for learning the basic concept of quantum nature of electrons will be developed with the help of undergraduate students at the university or K-12 physics teachers in the Buffalo region. Modern teaching methods will be implemented in introductory physics courses for non-majors, thereby improving the learning experience and scientific awareness among a wider student body. The results of the research and educational activities will be disseminated to the general public through participation in local art festivals and New York States STEP program Show more... | National Science Foundation | 8/19/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $173,995.00 | Grant | Trans-NIH Recovery Act Research Support Moraxella catarrhalis is a Gram-negative human mucosal pathogen, a significant cause of middle ear infections and sinusitis in infants and children and an important source of exacerbations in adults with lung disease. It is the third leading cause of otitis media (OM) and there is a high colonization rate with M. catarrhalis, as 50% of children will be colonized in the first 6 months of life. The incidence of OM is also high and as about 80% of all children under under 3 will experience at least one episode. In addition, recurrent acute OM is prevalent resulting in hearing impairment and developmental/learning problems as these children reach school age. OM is a significant source of direct and indirect health care costs and M. catarrhalis is responsible for 3 to 4 million physician office visits annually. This is considered low as diagnosis is difficult because tympanocentesis is uncommon. These facts have stimulated research aimed at identifying virulence factors involved in pathogenesis. One of the prominent surface components implicated as a virulence factor is the lipooligosaccharide (LOS). Structural analysis confirmed that M. catarrhalis LOS shares similarities with the LOS of Gram-negative human pathogens, i.e. Neisseria meningitidis, N. gonorrhoeae and Haemophilus influenzae. More importantly, these common carbohydrate epitopes are involved in virulence, i.e. adherence, biofilm formation and serum resistance. To date there has been little effort to evaluate the role of M. catarrhalis LOS in disease. The most likely reason for the lack of research in this area involves the fact that there was no data describing the genes involved in the biosynthesis and assembly of M. catarrhalis LOS and there were no defined mutants that could be used to delineate the importance of different oligosaccharide structures. We have made significant progress in this area over the previous period identifying 17 LOS genes and constructing each specific mutant. In addition, we have proposed a potential animal colonization model, together with our collaborators, which could be critical in performing in vivo studies with M. catarrhalis. We are now in a position to continue genetic and biologic studies designed to test our hypothesis that the serotype LOS structure assembled by M. catarrhalis isolates is directly related to pathogenesis. We further hypothesize that the serotype A and serotype B LOS structures may provide an advantage over the serotype C LOS structure. We will test our hypotheses by the following specific aims: (1) Determine the sequential steps involved in the assembly and biosynthesis of M. catarrhalis LOS and (2) Determine the role of M. catarrhalis LOS structures in pathogenesis. Middle ear infections are quite prevalent among you children. It is estimated that over 80% of children under the age of 5 will experience at least one of these types of infections. Moraxella catarrhalis is an organism that causes 15-20% of all bacterial middle ear infections. This generates a significant health care issue and there is significant interest in identifying vaccine targets. Therefore it is critically important to investigate bacterial components that could be vaccine antigen such as the lipooligosaccharides that are the focus of this work. Show more... | National Institutes of Health | 7/17/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $114,782.00 | Grant | Trans-NIH Recovery Act Research Support The scope of our ongoing research is to understand the mechanisms by which Candida albicans Hsp70 protein (Ssa1 and Saa2p) bind to and mediate uptake of salivary Histatin 5 (Hst 5), with the long-term goal of development of peptide-based alternative therapies for oral candidiasis. We found that although Ssa1p is more abundant than Ssa2p in C. albicans, it has a minimal role in Hst 5 binding, translocation and killing. Unexpected, we found Ssa1p is essential for oral and systemic virulence of this organism, and transcriptional analyses of ssa1 / cells identified 21 significantly down-regulated genes including cell wall adhesins such as PIR33. Since Hsp70 is known to bind both transcription factors and promoter region DNA in other yeast, we asked whether Candidal Ssa1p could regulate gene transcription though direct binding to promoter regions. Using EMSA analyses, we found that Ssa1p can specifically interact with PIR33 promoter GC rich DNA region, supporting its involvement in transcriptional regulation. These data point to an exciting new role for Ssa1p in C. albicans that involves regulation of gene expression by binding to transcriptional factors or DNA, or perhaps control of mRNA decay. We will investigate these possibilities by 1) identifying C. albicans genes regulated by Ssa1p using intergenic transcriptional profiling of Ssa1p with ChIP-Chip assays, and 2) determining whether Ssa1p can target RNA directly to control mRNA decay rates. These proposed experiments are outside the original aims of the Parent Grant DE10641project, therefore, this revision application requests funding for these studies in the remaining year of the parent project. We anticipate that data generated from this aim will accelerate the tempo of research by showing a novel role of ssa1p in transcriptional regulation of genes involved in the virulence of C. albicans, and allow for job creation by hiring an additional post-doctoral fellow to complete this aim. PUBLIC HEALTH RELEVANCE: As a part of the funded aims of our project, we found that Hst 5 uptake into the yeast cell and its killing ability requires primarily C. albicans Ssa2p, but that Ssa1p is required for fungal virulence in both systemic and oral thrush. Therefore, additional funding is requested to test whether Ssa1p can function as a DNA-binding transcriptional factor or co-activator of C. albicans genes by whole-genome transcriptional profiling of Ssa1p using ChIP-Chip assays, or if Ssa1p regulates gene expression by targeting RNA molecules directly to control mRNA decay rates in order to define a novel role of Ssa1p in transcriptional regulation of genes involved in the virulence of C. albicans. The proposed experiments will be accomplished during the final year of the parent grant and accelerate the tempo of our research by generating new data for additional publications and a new research project. Show more... | National Institutes of Health | 9/25/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $30,618.00 | Grant | Trans-NIH Recovery Act Research Support Controlling transcription termination upstream of a coding region is a common strategy to regulate gene expression in bacteria, including many with importance to human health. Such control mechanisms are collectively termed attenuation and antitermination. The proposed research will investigate the mechanisms by which RNA binding proteins recognize and bind to specific sites in RNA, and how these interactions regulate transcription. The mechanism by which protein-protein interactions can modulate the activity of an RNA-binding gene regulatory protein will also be studied. The model system of study is the TRAP protein, an RNA binding protein that regulates transcription attenuation of the tryptophan (trp) genes in Bacillus subtilis and related bacteria. In the presence of excess tryptophan, TRAP is activated to bind to the 5' leader region of the trp operon mRNA and induce formation of a transcription terminator, which halts expression of the genes. TRAP is a unique among characterized RNA binding proteins in that it consists of 11 identical subunits arranged in a ring structure, and in that it binds RNAs that contain up to 11 small (trinucleotide) repeated elements. Recent studies indicate that TRAP binds to RNA by a two-step mechanism. The hypothesis to be tested is that TRAP first binds to the 5'-end of the RNA and then scans until it encounters the 5-most repeats of the binding site, at which point an initiation complex is formed. This is followed by wrapping the remainder of the repeats around the outer perimeter of the protein ring. The detailed mechanism by which TRAP associates with its RNA target will be characterized using a combination of kinetic binding studies, as well as rapid-quench nuclease protection and fluorescence studies. A protein called anti-TRAP (AT) specifically binds to tryptophan-activated TRAP and inhibits it from binding to RNA. Studies will be performed to characterize the structure and function of AT, particularly the mechanism by which it recognizes and binds to TRAP. Show more... | National Institutes of Health | 8/14/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $263,066.00 | Grant | Highway Planning Highway Infrastructure Investment Grant: Available | Federal Highway Administration | 5/26/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $33,543,280.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Areas wit
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 5/26/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $1,780,000.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 3 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 6/18/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $610,000.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 5/26/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $660,000.00 | Grant | Highway Planning Highway Infrastructure Investment Grant: Available | Federal Highway Administration | 4/29/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $162,000.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 4/29/2009 |
| COMMUNITY HEALTH CENTER OF BUFFALO, INC. | $178,698.00 | Grant | ARRA-Health Center Integrated Services development Initiative ARRA - Increase Services to Health Centers: In response to community need, funds are requested to expand hours and social work services, plus conduct outreach to the unemployed and uninsured. Existing services include: primary care, dentistry, psychosocial services, lab work, 340B pharmacy, education, and care coordination with specialists. The Community Health Center of Buffalo, Inc. (CHCB) has expertise and experience to meet challenges of expanding health care during this difficult economic climate. The proposed strategies to expand access to primary care services and increase capacity include: retaining a physician assistant; hiring five part time employees (physician assistant, nurse practitioner, registration clerk and medical assistants) to expand hours/capacity; hiring a social worker to assist new and uninsured or unemployed patients to access needed social services; and hiring a part-time outreach worker to work with soup kitchens, food pantries and organizations providing unemployment services to increase awareness of expanded availability of CHCB staff for health care services. Starting June 1, 2009, the CHCB will expand hours to include Saturday, 9 AM to 5 PM. Also, there will be increased access to comprehensive care management, because the CHCB approach integrates a continuum of services (outreach, risk assessment, education, prevention, medical care, social support, follow-up and relapse prevention) to improve community wellness. The CHCB will target the disconnected and unconnected medically underserved individuals and special needs populations. Increased access will result in health status improvements and reduced numbers of patients who use the Emergency Department (ED) as their medical home. The CHCB is working toward becoming Buffalo's core provider of primary care and is strategically working with hospital EDs to link patients to medical homes. Care management and outreach are critically needed during these difficult economic times but these services are time-framed for the two-year grant period. Expanded hours will be sustained through increased patient volume. The CHCB will make a tangible and measurable impact by providing culturally competent primary and preventive care for the underinsured and uninsured. There will be 1,100 new patients, including 300 uninsured. Procedures for gathering measuring outcomes, including projected numbers, are based on the CHCB's medical records system that tracks measurable indicators of performance. The CHCB's Quality Assurance Committee meets monthly to review audits generated through electronic medical records. The CHCB will base its services evaluation on the indicators recommended by HRSA. Impact Factors: The CHCB has several factors that inherently support success: existing primary care location - located on a bus route, making it readily accessible to residents; outreach to the uninsured and unemployed; experienced CHCB administration; and alignment with local hospitals for bi-directional referrals. Positive economic impact will be demonstrated by creating 3.85 FTE new jobs and retaining 1.0 FTE job. Total New Patients (Unduplicated): 1,100. Total New Uninsured Patients: 300. The CHCB supports local businesses since our employees live in the community. Show more... | Health Resources and Services Administration | 3/27/2009 |
| KENMORE MUNCIPAL HOUSING AUTHORITY | $308,762.00 | Grant | Public Housing Capital Fund Stimulus (Formula) Recovery Act Funded Emergency Generator Replacement, Hallway Flooring | Department of Housing and Urban Development | 3/18/2009 |
| NORTHWEST BUFFALO COMMUNITY HEALTH CARE CENTER | $192,883.00 | Grant | ARRA-Health Center Integrated Services development Initiative The Increased Demand for Services grant | Health Resources and Services Administration | 3/27/2009 |
| HEALTH RESEARCH, INC. | $73,209.00 | Grant | Trans-NIH Recovery Act Research Support This application proposes a 5 year translational research training program for the development of an academic career in urologic oncology. The applicant completed urology residency at the University of Chicago and fellowships in urologic oncology and minimally invasive surgery at the University of California, Los Angeles. This program provides training for translating basic science concepts into novel therapeutic strategies. Specifically, a heat shock protein-based vaccine targeting a kidney cancer antigen, resulting from the underlying VHL mutation, is developed under the mentorship of Dr. John Subjeck, a well recognized leader in the field of heat shock proteins. Dr. Subjeck has mentored numerous graduate, postgraduate students, and several junior clinicians. Co-mentors for this project include Dr. Elizabeth Repasky, Professor of Immunology, and Dr. James Mohler, Professor of Urologic Oncology, who has combined translational research and clinical practice in a successful academic urology career. Heat shock proteins (HSPs) are potent immune activators. The mentor's laboratory first demonstrated the feasibility of using the natural chaperoning function of HSPs to bind tumor antigens and produce an antitumor immune response. The major hypothesis of the proposed research is that HSPs complexed in vitro to a kidney cancer protein will serve as an effective vaccine for kidney cancer. The specific aims are: 1) Determine if heat shock complexes of HSP and tumor antigen prevent tumor formation (prevention study) and treat established tumors (treatment study) in a murine model of renal cell carcinoma (RCC), and compare vaccine efficacy to other heat shock protein based vaccines strategies; 2) Determine if HSP complexed to tumor antigen stimulates human peripheral blood monocytes and generates antigen-specific cytotoxic lymphocyte (CTL) response; 3) Perform a phase I clinical trial using HSP complexed to tumor antigen as a tumor vaccine in patients with advanced, clear cell RCC. Currently available therapies for metastatic kidney cancer produce modest response rates of 15-20%. Advances in the understanding of the molecular mechanism underlying the disease have revealed new therapeutic targets. A novel, immunotherapy targeting a kidney tumor-specific antigen is proposed. Show more... | National Institutes of Health | 9/15/2009 |
| TONAWANDA, TOWN OF | $772,574.00 | Grant |
Homelessness Prevention and Rapid Re-Housing Program (Recovery Act Funde The Homelessness Prevention and Rapid Re-Housing Program will provide financial assistance and services to prevent individuals and families from becoming homeless and help those who are experiencing homelessness to be quickly re-housed and stabilized. The funds under this program are intended to target individuals and families who would be homeless but for this assistance. The funds will provide for a variety of assistance, including: short-term or medium-term rental assistance and housing relocation and stabilization services, including such activities as mediation, credit counseling, security or utility deposits, utility payments, moving cost assistance, and case management. The Tonawanda Temporary Assistance Program details may be viewed at: http://www.tonawanda.ny.us/commdev/ Show more...
There were 3 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Department of Housing and Urban Development | 7/23/2009 |
| NIAGARA FRONTIER TRANSPORTATION AUTHORITY | $409,946.00 | Grant | The purpose of this grant is to invest in public transportation by upgrading the Niagara Frontier Transportation Authority (NFTA) Metro Rail's power support system. NY-56-0002-00 entails the purchase of Uninterruptible Power Supply (UPS) Batteries and Traction Power Substation Batteries for the 6.2 mile rail line in Buffalo, New York. Show more... | Federal Transit Administration | 8/21/2009 |
| BOSTON,TOWN | $156,700.00 | Grant | TOA Code 544, Water only combo loan/grant - Rural Development funds will be used to install a water main and a booster pumping station in order to provide safe, clean drinking water to residents who currently rely on unhealthy wells. The project will benefit 13 users. | Rural Utilities Service | 6/30/2009 |
| CAYUGA VILLAGE ASSOCIATES LIMITED PARTNERSHIP | $422,396.00 | Grant | Section 8 Housing Assistance Payments Program Special Allocations (Recover Rental Assistance Payments | Department of Housing and Urban Development | 3/16/2009 |
| D'YOUVILLE COLLEGE | $52,393.00 | Grant | FEDERAL WORK-STUDY PROGRAM Federal Work-Study provides need based financial a | Department of Education | 7/01/2009 |
| MEDAILLE COLLEGE | $52,393.00 | Grant | FEDERAL WORK-STUDY PROGRAM Federal Work-Study provides need based financial a | Department of Education | 7/01/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $299,000.00 | Grant | Trans-NSF Recovery Act Research Support This award supports theoretical research and education focused on electron-phonon kinetics and electric, thermal, and thermomagnetic transport in low-dimensional conductors, nanomaterials, and strongly correlated materials such as doped Mott dielectrics, e.g. novel superconductors and conducting polymers. Vibrating boundaries, defects, or dopants generates another channel of electron-phonon interaction, which interferes with the usual electron-phonon and elastic electron scattering. The interference of scattering mechanisms drastically modifies kinetic and transport phenomena. The interference effects can be strong and easily observable. While effects of interference have been known for some time, the research in this field is limited. The PIs will investigate electron-phonon kinetics and electric, thermal, and themomagnetic transport in low-dimensional structures, such as heterostructures, ultrathin films, multi-walled carbon nanotubes, nanowires, metallic clusters, and quantum dot arrays. In low dimensions, strong enhancement of interference effects is expected due to a smaller electron momentum transfer and due to intrinsic peculiarities in the momentum transfer related to the collective excitations. The PIs will investigate electron-phonon interference effects in specific materials, such as graphene and various doped Mott dielectrics. The research is aimed to contribute to the development of critical insights into the quantum interference of scattering mechanisms in kinetics and transport and will contribute to significantly improved theoretical techniques, related to the quantum transport equation and Feynman-Keldysh diagrammatic techniques. This research program contributes to developing effective ways to manage electron-phonon transport and energy transfer which will, in turn, strongly impact the development of advanced nanodevices and materials. A number of puzzling experimental results will find their explanation in the framework developed by this program. The project will have broader impacts through its contributions to education, and by developing theoretical models that can have impact in materials science and engineering. Nanoscale thermal management will substantially affect practically all branches of the electronics industry. This research will have immediate impact on the development of nanodevices in which energy transfer is ?tailored? to specific applications, e.g. ultrasensitive nanocalorimeters and single quanta nanodetectors operating at low and moderate temperatures. With graduate and undergraduate students, the PIs will develop a set of specialized experiments for elementary and high school students. These demonstrations are directly related to modern electronics and nanotechnology. The PIs will incorporate information technologies via Java Applets; they are extending these applets to incorporate the nanoworld energy transfer. They are also developing an interactive exhibit for the Physical World Science Studio of the Buffalo Museum of Science that will help to promote nanotechnology to a broader public. Lectures and demonstrations will be developed at a level appropriate for the general public. NON-TECHNICAL SUMMARY This award supports theoretical research aimed to elucidate the microscopic mechanisms that control how heat and electricity flow through materials structures and devices that are thousands of times smaller than the diameter of a human hair. The PIs will develop a theory on the level of electrons and the atomic-scale surfaces and defects, and vibrations that they encounter as they flow through these tiny structures. This project will contribute to the intellectual foundations for managing heat dissipation at small length scales anticipated for future circuit feature sizes of semiconductor devices. ?The complete abstract for this award is available in Research.gov at www.research.gov? Show more... | National Science Foundation | 9/14/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $845,796.00 | Grant | Trans-NSF Recovery Act Research Support The ICCAP research project's main goals are 1) the extent to which the circumpolar area has been subject to varying trends of environmental change in the past and 2) the similarities and differences in human adaptations to these changes in different areas of the Arctic. The research team will employ a well tested collection of direct and indirect proxies of climate and human adaptation based upon methods from dendro-climatology, palynology, geo-chemistry, climate modeling, ethnography, and archaeology. The very successful predecessor of this project, SCENOP of the European Science Foundation BOREAS program, created and compared two data sets from northern Finland and northern Canada. ICCAP creates a new data set from northern Russia and combined with its predecessor will provide three approximately equidistant placed research areas encompassing the entire the circumpolar world. For each research area, the employing the same research teams using the same methodologies at the same levels of resolution makes possible meaningful comparisons from uniformly collected data. ICCAP adds to the existing ?two way? (Finland, Canada) comparison, two new two way comparisons (Finland, Russia) (Canada, Russia), as well as making truly three way comparisons among the data sets (Finland, Canada, Russia). Because of the circum-global geographic locations, Yli-ii Finland, Wemindji Quebec Canada and Ust-Kamchatsk, Kamchatka, Russia, ICCAP will make circumpolar generalizations. By using a long-term perspective on human responses to climate and environmental change in these three coastal circumpolar locations between 60 and 78 degrees N latitude and 7000 to 3000 years ago, the researchers proposed to answer some basic questions that are important for science and policy. For example: in the long run, several thousand years, are yearly average temperatures more important than seasonal temperatures Are absolute temperature and precipitation changes more important than the variability in temperature and precipitation? Does diversity of environmental change result in increasing stability or diversity of human adaptation Are there thresholds that must be met in environmental change or in human adaptation before changes occur Does human adaptation to environmental or climate change need to be reactive or may it successfully be pro-active The circumpolar north widely is seen as a critical observatory for understanding environmental change and human adaptation. This is particularly true today since the effects of global warming are most clearly visible in the Arctic where reality has exceeded expectations?. Ultimately, this project proposes to explain the past and the potential range of human resilience when faced with global and local environmental changes. Taken from the circumpolar perspective, the research team believes that this information has the potential to aid policy makers as they enter into debates on new post-cold-war partnerships, and set policy concerning such issues as energy, post-colonial governance, and strategy. Show more... | National Science Foundation | 6/09/2009 |
| MARILLA, TOWN OF | $348,730.00 | Grant | TOA Code 544, Water only combo loan/grant - Rural Development funds will be used to install 15,000 feet of PVC pipe with one large and three small creek crossings to improve water for residents in the area who are experiencing insufficient quantity and poor water quality. The project will benefit 148 users. Show more... | Rural Utilities Service | 9/04/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $1,055,383.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 4/29/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $120,000.00 | Grant | Trans-NSF Recovery Act Research Support The study of the fundamental physics that governs evolution of our universe is one of the most exciting research fields in modern physics. In the last two decades, technological advances have made possible a host of cosmological observations strongly constraining the properties of the universe and making possible the formulation of the Standard Model of cosmology in analogy with the Standard Model of particle physics. At the same time, direct cosmological observations are almost always complemented by data from particle accelerators, earth-based detectors and cosmic ray observatories. Along these lines, the proposed project will have two aspects. The first aspect is related to fundamental theoretical cosmology and envisions a concerted research effort towards understanding and explaining the puzzle of dark energy. The approach to this problem that will be explored is based on the idea of the late time phase transitions in the universe, where the field responsible for the phase transition carries gauge charges. Such models have a very good chance to be tested in near future collider experiments. The second aspect of the project will be tightly connected to models with large extra dimensions that can accommodate a TeV-scale gravity. Probably the most interesting and intriguing feature of these models is the possibility of production of mini black holes in future collider experiments. The project envisions building a black hole event generator for the LHC which will play an important role in confirming or excluding this class of models. This event generator (tentatively called BlackMax) will be integrated into the ATLAS Monte Carlo programs Herwig and Pythia.. The broader impact of the proposed activities is that they will lead to an improved understanding of the possible connection between dark energy and the Standard Model. This would further link cosmological observations with fundamental physics. This project will provide an excellent training ground for students at both the undergraduate and graduate level. Developed numerical tools as well as the black hole event generator itself will be made public for the benefit of a wider physics community. Scientific results will presented at national and international conferences and workshops. The PI is also a guest Lecturer at 'Petnica Science Center' which is a center for gifted high school students. Show more... | National Science Foundation | 6/08/2009 |
| NIAGARA FRONTIER TRANSPORTATION AUTHORITY | $2,234,070.00 | Grant | ARRA Rail and Transit Security Grant Program American Recovery and Reinvestment Act Rail and Transit Security Grant Program-Law Enforcement. The purpose of this grant is to reduce transit system risks and stimulate job creation. The grant will fund the salaries of six new Niagara Frontier Transportation Authority (NFTA) Transit Police Department Officers, including two new K-9 team transit police officers for three years, and two trained K-9 team police dogs. Training, equipment, and support for the new officers will be funded as well. Show more... | Federal Emergency Management Agency | 7/31/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $142,011.00 | Grant | Trans-NIH Recovery Act Research Support There is an urgent need to develop new means for potentiating protective immune responses against pathogens that infect the oral, gastric and urogenital mucosae. The objective of this proposal is to evaluate the mucosal adjuvant activities of LT-IIa and LT-IIb, two Escherichia coli Type II enterotoxins. LT-IIa and LT-IIb induce distinctive patterns of enhanced immune responses which are profoundly different from those induced by cholera toxin (CT). Whereas CT commonly induces a predominant Th2-type response based on antibody isotype and cytokine patterns, mice administered with Type II enterotoxins as adjuvants exhibit a more balanced Th1/Th2 response. We have also demonstrated that LT-IIa, LT-IIb, and CT interact with different populations of lymphocytes and induce in those populations distinctive cellular responses (apoptosis, cytokine production, proliferation, etc.). Collectively, these data provide strong evidence that LT-IIa and LT-IIb (and CT) utilize different cellular and molecular mechanisms for immunomodulation. Our hypothesis is that the distinctive adjuvant activities of LT-IIa and LT-IIb (and CT) are elicited by their binding affinity for different receptors on immunocompetent cells which are required to trigger specific signal transduction events. To test this hypothesis, the adjuvant activities of the LT-IIa and LT-IIb, and a collection of mutant enterotoxins with altered receptor-binding activities, will be analyzed in a mucosal mouse model using Agl/II of the oral pathogen Streptococcus mutans as a model antigen. Other LT-IIa and LT-IIb mutants will be engineered to establish the importance of ADP- ribosylation and cellular trafficking in immunomodulation. Prior investigations have revealed a receptor on lymphocytes which is likely the trigger for the adjuvant activities of LT-IIb. Ablation and blocking experiments using relevant lymphocytes will be used to characterize the receptor. The affect of the enterotoxins on the cellular and molecular responses of dendritic cells, the major sentinel antigen- presenting cells of the mucosa, will be investigated as a further means to correlate the adjuvant activities of LT-IIa and LT-IIb with particular lymphocytes. Efficacy of the mutant enterotoxins as protective mucosal adjuvants will also be determined using an established S. mutans murine colonization model. The fundamental information obtained herein will be essential for establishing the potential of Type II enterotoxins, or their non-toxic mutants, as mucosal adjuvants for subsequent vaccine use. Show more... | National Institutes of Health | 9/22/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $144,330.00 | Grant | Trans-NIH Recovery Act Research Support NMDA receptors (NRs) mediate fast excitatory transmission in the brain. Their activation is critical for the normal development, maintenance and continual remodeling of excitatory synapses. Excessive NR activity is a disease mechanism in stroke, chronic pain, epilepsy, and neurodegenerative disease, whereas insufficient NR signaling has been involved with schizophrenia and cognitive disorders. Numerous endogenous and pharmacologic agents modulate NR activities and are potential candidates for therapeutic intervention. The mechanisms governing the allosteric control of NR activity are poorly understood and empirical attempts to control NR function have so far yielded disappointing results. The OBJECTIVE is to understand how allosteric modulators control NR physiologic functions in terms of molecular mechanisms, integration and consequences on synaptic physiology. The AIMS addressed in this proposal are to: i) characterize individual NR allosteric modulators in terms of their effects on NR gating dynamics and on non-stationary macroscopic behaviors; ii) establish how multiple allosteric signals are integrated to result in responses with distinct signaling profiles; and iii) investigate how allosteric modulation of NR responses impacts on synaptic physiology. First, using kinetic analysis of single-channel currents and statistical modeling we will identify and quantify the actions of individual modulators on NR elementary kinetic transitions during gating. These measured rate constants are intrinsically rich with mechanistic information; in addition they can predict modulator effects on NR macroscopic behaviors and on NR- mediated synaptic function. These predictions will be verified by measuring ensemble NR responses to patterned stimulation in excised membrane patches and by measuring evoked NR synaptic responses in brain slices. For NRs whose activation reaction is complex, this approach is entirely novel and may identify effective means to modulate specific receptor functions in separation of each other. Taken together the results will help to compile an integrated mechanistic view of how allosteric control of NR activity impacts synaptic physiology. This view should suggest new, combinatorial approaches to specifically target harmful receptor behaviors while preserving the critical functions played by NRs . Show more... | National Institutes of Health | 9/25/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $31,545.00 | Grant | Trans-NIH Recovery Act Research Support We propose to develop a photonic-based sensing layer for the spatial and temporal determination of proteins within the microenvironment of a wound. This program will combine Protein Imprinted Xerogels with Integrated Emission Sites (PIXIES) with photonic bandgap structures to provide a flexible protein sensing film that can be directly integrated into a point-of-care solid state system for wound status determination. These protein sensing films can be directly integrated with Complementary Metal Oxide Semiconductor (CMOS) technologies to provide low-power, portable, hand held systems for clinical applications. The composite sensing films will be fabricated using optical interference lithography combined with pin-printing. The resulting new class of organic PBG-based sensors integrated with our PIXIES technology that will enable real time assessment of biomarkers that are significant in the care of patients with acute and chronic wounds. The first six months of the project will focus on the demonstration of selectivity and sensitivity of a PIXIES array to multiple proteins printed on a flexible polymer substrate, and imaged using a CCD camera, for in-vitro wound assessment. This will be followed by the development of a porous photonic bandgap (PBG) architectures that can be directly integrated with the PIXIES to efficiently collect the protein-concentration-dependent fluorescence emission from the PIXIES elements. These hybrid PIXIES/PBG structures will be validated using in-vitro wound assessment. The enhanced emission collection efficiency of the PIXIES/PBG structures will enable the use of low cost, low gain, CMOS technologies that can enable rapid dissemination of the developed instruments as portable test equipment. Finally, once there is sufficiently enhanced sensitivity to signal changes, i.e., better resolution of analyte concentration for real time wound assessment will be demonstrated. We intend to use the results from this R-21 as the starting point for the development of a handheld point of care device using a CMOS based low power, hand-held analysis system for in-vivo wound analysis through RO-1 sponsored funding. PUBLIC HEALTH RELEVANCE: Real-time wound analysis has the potential to translate to decreased patient morbidity and health care cost in clinical applications. It is estimated that on any given day 60 million people worldwide are being treated for chronic, non-healing wounds and the ability to tailor patient treatment to obtain improved outcomes has been difficult. The ability to analyze the microenvironment of a wound will result in personalized health care for individual patients that should result in significantly improved healing outcomes. Show more... | National Institutes of Health | 6/16/2009 |
| HEALTH RESEARCH, INC. | $248,377.00 | Grant | Trans-NIH Recovery Act Research Support This proposal is being submitted in response to NOT-OD-09-058, titled 'NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications.' We propose to expand our NCI R25T funded postdoctoral training program in prevention with the addition of one trainee capable of completing the program in two years. Our program is now at full capacity with four postdoctoral fellows; three are population scientists and one is a basic scientist. The fifth trainee will be a basic scientist who can use his/her expertise and contacts in the areas of chemoprevention and biomarkers while developing research skills in the behavioral, nutritional and/or social sciences. Our vision of cancer prevention at Roswell Park Cancer Institute (RPCI) is drawn from extending the 'bench to bedside' paradigm of translational research. Under the leadership of James Marshall, PhD, Senior Vice President for Cancer Prevention and Population Sciences (CPPS), it has been broadened into a 'bench to sidewalk' model, integrating basic bench, clinical, epidemiologic and population sciences. In this vision, prevention demands the translation of basic science as much as cancer treatment does. Prevention also requires that the basic bench sciences -- genetics, biochemistry and molecular biology -- be integrated with the sciences of prevention: epidemiology and population sciences. Our training program, based in CPPS, builds on Roswell Park's strengths: an established history of multidisciplinary collaboration; a strong group of mentors with numerous funded research projects; and collaboration with the University at Buffalo. The requested revision will use the infrastructure of our existing program to equip an additional basic scientist with the principles, methods and practices needed for cancer prevention research. Our comprehensive training program encourages and supports innovative transdisciplinary research and professional development. The proposed revision will meet the Recovery Act objectives of job creation and accelerating the pace of scientific research by employing a postdoctoral fellow for two years and by training that fellow to launch an independent research career. Show more... | National Institutes of Health | 9/29/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $366,736.00 | Grant | Trans-NIH Recovery Act Research Support It is estimated that up to 50,000 children are newly diagnosed annually in the United States with vesicoureteral reflux (VUR) after a urinary tract infection. It is known that in some of these children, VUR is associated with recurrent infection, pyelonephritis and subsequent renal scarring. This can lead to hypertension and renal insufficiency later on in childhood or in adult life. There remains great confusion, however, regarding the optimal treatment of these children or indeed, if they all require treatment. While it appears that children with the higher grades of dilating reflux (grades IV & V) are at the greatest risk for clinical sequelae, they are a minority of patients. 90% of children have grades I, II or III reflux. The majority of children with low grade reflux will outgrow their reflux before adolescence. Surgical correction of reflux in these children is less commonly required, therefore. Rates of renal scarring and recurrent urinary tract infection are also lower in these children. While long term antibiotic prophylaxis works well in preventing urinary infection, it has been proposed that it may not be necessary in this group, since rates of scarring and recurrent infection are low with low grade reflux. Recently, a new minimally invasive treatment of reflux has been developed and a material known as 'Deflux' has been approved by the FDA for this purpose. This material is injected via a cystoscope around the ureteral orifice. The change in configuration of the orifice caused by this bulking agent cures the reflux. Because of its ease of use and low morbidity of application, it has been proposed that this be employed as initial therapy in the majority of children with low grade reflux. Successful treatment with Deflux might render the need for long term surveillance, either on or off antibiotics unnecessary. The optimal treatment for the majority of the thousands of children with reflux, therefore, remains unknown. Do they simply require daily antibiotics? Can they be safely observed without prophylaxis? Do they require an ambulatory cystoscopic procedure? A prospective randomized study is proposed to answer this question in girls, aged one to five years with grades II or III reflux, diagnosed after a urinary tract infection. The three major treatment groups would be antibiotic prophylaxis, observation without prophylaxis, or endoscopic therapy with Deflux (ET). The clinical endpoints measured would be recurrent febrile or non-febrile urinary infections and renal scarrin Show more... | National Institutes of Health | 8/21/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $800,000.00 | Grant | Highway Planning Highway Infrastructure Investment Grant: Urbanized | Federal Highway Administration | 9/16/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $300,000.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 2 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 7/01/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $620,000.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 2 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 7/01/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $841,570.00 | Grant | Highway Planning Highway Infrastructure Investment Grant: Available | Federal Highway Administration | 5/19/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $491,210.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 6/02/2009 |
| NORTHWEST BUFFALO COMMUNITY HEALTH CARE CENTER | $559,995.00 | Grant | ARRA-Health Center Integrated Services development Initiative The Capital Improvement Project is providing funds needed to prepare NWBCHCC for Electronic Health Records. This includes purchasing licenses for Allscripts Practice Management and Eleectronic Health Records. In addition, the funds are being used to upgrade outdated Information Technology equipment including, servers, computers, routers, phones and the network infra structure. Show more... | Health Resources and Services Administration | 6/25/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $304,179.00 | Grant | Trans-NSF Recovery Act Research Support A recently developed technology, called opportunistic coding, can greatly improve the effciency of wireless networks. However, the problems of cooperation and security in opportunistic-coding-based (OCB) wireless networks have not received suffcient attention. Here cooperation problems are the problems introduced by the existence of selfish nodes in the wireless networks, while security problems are the problems introduced by the existence of adversarial nodes. This work is to design and implement solutions that can provide cooperation and security guarantees for OCB wireless networks. The research work can be divided into studied of three problem areas, namely the cooperation problems, the security problems, and the interplays of cooperation and security. The work also includes the dissemination of related knowledge to students at various levels. Intellectual Merit: The results of this work will signiffcantly improve OCB wireless networks in terms of cooperation and security. Furthermore, these results will also have broader theoretical interests, because a part of the techniques to be developed will be applicable to economic incentives problems in other settings as well. Broader Impacts: First, the developed technical solutions will benefit the society because they make it possible to widely deploy OCB wireless networks to environments with selfish or adversarial nodes. Second, the educational component of this work will build capacity in cooperation and security at various levels. Show more... | National Science Foundation | 8/14/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $539,086.00 | Grant | Trans-NSF Recovery Act Research Support From representation to learning to inference, effective use of high-level semantic knowledge in computer vision remains a challenge in bridging the signal-symbol gap. This research investigates the role of semantics in visual inference through the generalized image understanding problem: to automatically detect, localize, segment, and recognize the core high-level elements and how they interact in an image, and provide a parsimonious semantic description of the image. Specifically, this research examines a unified methodology that integrates low- (e.g., pixels and features), mid- (e.g. latent structure), and high-level (e.g., semantics) elements for visual inference. Adaptive graph hierarchies induced directly from the images provide the core mathematical representation. A statistical interpretation of affinities between neighboring pixels and regions in the image drives this induction. Latent elements and structure are captured with multilevel Markov networks. A probabilistic ontology represents the core knowledge and uncertainty of the inferred structure and guides the ultimate semantic interpretation of the image. At each level, rigorous methods from computer science and statistics are connected to and combined with formal semantic methods from philosophy. A symbiotic education plan involving graduate and undergraduate mentoring and education, professional tutorial courses at the boundary of vision and ontology, and K-12 outreach is incorporated into the research plan. The research and education, disseminated broadly through both the applied science and semantics/philosophy literatures, lays a foundation on which to both utilize and automatically extract rich semantic information from images and other signal data for critical application areas such as internet vision, autonomous navigation, and ambient biometrics. Show more... | National Science Foundation | 6/26/2009 |
| NIAGARA FRONTIER TRANSPORTATION AUTHORITY | $24,430,788.00 | Grant |
Capital and Operating Assist Formula Grants The purpose of this grant is to invest in public transportation by purchasing new transit buses. Project NY-96-X017-00 entails the procurement of fifty-six (56) new diesel buses which will replace a like amount of life expired 40-foot diesel buses. The buses will operate in daily transit service throughout Niagara Frontier Transportation Authority’s (NFTA) 1,575 square mile service area of Erie and Niagara Counties in New York State. Show more...
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Transit Administration | 8/21/2009 |
| BUFFALO MUNICIPAL HOUSING AUTHORITY INC | $14,510,364.00 | Grant | Public Housing Capital Fund Stimulus (Formula) Recovery Act Funded Capital Fund Program ARRA formula grant | Department of Housing and Urban Development | 6/02/2009 |
| BUFFALO URBAN RENEWAL AGENCY | $6,594,081.00 | Grant |
Homelessness Prevention and Rapid Re-Housing Program (Recovery Act Funde It is estimated that this program will be able to
There were 9 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Assistant Secretary for Community Planning and Development | 8/13/2009 |
| ERIE, COUNTY OF | $1,209,200.00 | Grant |
Homelessness Prevention and Rapid Re-Housing Program (Recovery Act Funde The Homelessness Prevention and Rapid Re-Hoising Program shall provide housing assistance to low income individuals and families that are homeless or at risk of becoming homeless. The Program, named Erie County Housing/Homeless Outreach Program, shall provide financial assistance and cousneling service to approximately 1000 homeless or at risk of becoming homeless households in the Erie County CDBG Consortium. Financial assistance will be available to assist eligible households to pay rent, utility payments, security deposits, moving assistance, motel/hotel vouchers. In addition to financial assistance eligible households shall receive case management, legal services, housing search/placement and credit repair, if needed. Show more...
There were 2 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Assistant Secretary for Community Planning and Development | 7/20/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $300,000.00 | Grant | Trans-NSF Recovery Act Research Support This research project investigates climatic change from a global perspective through archaeological excavation and survey in the Puuc region of Yucatan, Mexico and at the Maya center of Xcoch. Climate change in the Arctic is not just a contemporary phenomenon, such change had social and cultural consequences for many past human societies far from northern Polar Regions, including the Maya lowlands. Changing climate facilitated Norse colonization of the North Atlantic Islands during the Medieval Warm Period (AD 800-1300). At about the same time, the Maya of Yucatan, Mexico, were experiencing disruptions to rainfall patterns leading to sustained periods of drought. How Arctic climate change affected processes of cultural development and decline in the North Atlantic and Maya Lowlands has the potential to inform us today regarding the far reaching and serious cultural-environmental impact of global climate change. Climate data from places like the Puuc region, characterized as a semi-arid tropical climate and dry forest vegetation that suffers from a long precarious dry season, has the potential to inform us about the complex effects that Arctic climate change had and has on the global climate system. Climate change has long been seen as a major factor in the decline of ancient Maya civilization. Cycles of drought affecting agriculture and available drinking water in particular are believed to have being critical in the phenomenon known as the Classic Maya collapse beginning around the 9th century AD. The site of Xcoch is uniquely suited for climatic change research because it had a long occupation but experienced significant depopulations by the 9th century, contains a deep cave to a permanent water source, and there are many ponding features (aguadas); all these factors give Xcoch the potential to provide long-term paleoclimatic information. The nearby centers of Uxmal, Muluch Tzekel, and Xuch also contain aguadas and there are several other deep caves in the region that will be tested. This work is largely based upon new, untested ideas and has never been tried in the Yucatan but involves new approaches, requires diverse expertise, and engages interdisciplinary perspectives. Survey and excavation at Xcoch will resume in 2009 when multidisciplinary climate change data will be collected, analyzed, and compared with northern data. This research engages the Arctic community because it is becoming increasingly apparent that Arctic climate changes have global culture-environmental impacts. In order to fully understand what those impacts are, interdisciplinary and cross regional investigations, such as the proposed project, need to take place both in the north and in the south engaging the scientific community in a global discussion. The data that the PI expects to uncover at Xcoch will be added to this ongoing discussion with northern scientists. This research is viewed as potentially transformational, connecting what up to this point have been primarily regionalized archaeological research on the affects of climate change on local social and cultural systems, the Xcoch project will attempt globalize this research by connecting the north with the south. Show more... | National Science Foundation | 9/28/2009 |
| COMMUNITY ACTION ORGANIZATION OF ERIE COUNTY INC | $1,174,675.00 | Grant | ARRA - Head Start FY2009 ARRA COLA/QI | Administration for Children and Families | 7/01/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $79,250.00 | Grant | Trans-NIH Recovery Act Research Support The incidence of late preterm births (defined as births at 34 0/7 to 36 6/7 wk gestation) have been steadily increasing over the past decade and account for the ~ 75% of all preterm births. Respiratory morbidity from disorders of transition including pulmonary hypertension (impaired pulmonary vasodilation), transient tachypnea of newborn (inadequate lung liquid clearance) and respiratory distress syndrome (inadequate surfactant production and release) affect late preterm infants at a higher rate than infants of more advanced gestational age. Practice guidelines of the American College of Obstetricians and Gynecologists (ACOG) recommend tocolysis and glucocorticoids to women in preterm labor up to 34 wk gestation. However, beyond 34 wk efforts are no longer directed at prolonging pregnancy or enhancing fetal maturity. Moreover, because of the inherent inaccuracy of pregnancy dating with margins of error up to 3 wk in the third trimester, inductions of labor and elective cesarean section performed at 'presumed term' might inadvertently contribute to the increasing incidence of late preterm birth. The Antenatal Steroids for Term Cesarean Section study reported that two doses of antenatal betamethasone significantly reduced respiratory morbidity in > 37 wk infants born by elective cesarean section. Administration of antenatal glucocorticoids to < 34 wk gestation mothers in preterm labor undoubtedly reduces a number of neonatal morbidities including respiratory distress and intraventricular hemorrhage. Given the promising results in infants > 37 wk in a single study, research evaluating the pulmonary physiological effects and benefits (or lack there of) of antenatal glucocorticoids for preterm labor between 34 and 36 6/7 wk is important. We propose to gain such insight by administering betamethasone to pregnant ewes prior to elective cesarean section. It may not be possible to prevent delivery for 48 h after initiation of an antenatal steroid course. Hence we plan to test two protocols: one dose of betamethasone administered 24 h prior to delivery and two doses administered 48 h and 24 h prior to delivery in this proposal. Late preterm lambs (134 d gestation, term ~ 145 d) delivered by elective cesarean section following two, one or no doses of antenatal betamethasone will either be sacrificed at birth (for evaluation of pulmonary vascular reactivity, lung liquid status, compliance and surfactant production and release) or instrumented for evaluation of pulmonary vascular resistance, oxygenation and ventilation for 6 h. We will study the changes in important mediators of pulmonary transition at birth such as nitric oxide, beta adrenergic agents, natriuretic peptides and prostaglandins secondary to antenatal glucocorticoid use. We hypothesize that antenatal administration of either one or two doses of betamethasone will enhance pulmonary vasodilation, lung liquid reabsorption and surfactant production in late preterm lambs delivered by cesarean section. These studies are likely to have an impact on the clinical protocol for use of antenatal steroids, changing current practice. PUBLIC HEALTH RELEVANCE: The number of births at 34 to 37 weeks of gestation, often referred to as late preterm births, delivered by cesarean section is rapidly increasing in North America. Treating late preterm pregnant mothers in labor with betamethasone (a steroid) may reduce the risk of respiratory complications and mortality in their infants. We intend to administer betamethasone to late preterm gestation ewes to study the benefit and mechanism of this treatment in fetal lambs delivered by cesarean section. Show more... | National Institutes of Health | 4/30/2009 |
| HEALTH RESEARCH, INC. | $321,845.00 | Grant | Trans-NIH Recovery Act Research Support The anti hormonal drug tamoxifen is approved for the treatment of women with early and advanced and early stage estrogen receptor (ER)-positive breast cancer. Tamoxifen is known to exert its effects on breast cancer cells by binding to the estrogen receptor, thereby preventing the binding of estrogen. However, a major clinical problem is that a large number of patients with ER-positive breast tumors either do not respond to tamoxifen therapy or develop resistance to it. Although several plausible reasons for such resistance have been suggested, the mechanisms of resistance to tamoxifen therapy remain largely unclear. The award is to test the hypothesis that relieving suppression of tumor suppressor p53 by estrogen receptor ?Ñ (ER?Ñ) could be an important mechanism underlying tamoxifen action in breast cancer patients. The benefit of tamoxifen¡¦s effect becomes irrelevant if the tumor has mutant (and therefore dysfunctional) p53, and therefore, p53 status and tamoxifen¡¦s ability to activate p53 function could be important factors in resistance to tamoxifen therapy. To test these hypotheses, a pilot randomized clinical trial of 50 pre-menopausal women with newly diagnosed ER-positive breast cancer expressing wild type p53 is proposed. The award will support this clinical trial. The Specific Aims are: (1) Investigate the status of ER-p53 interaction in patients treated with 20 mg of tamoxifen for four weeks prior to surgery as compared to the interaction in untreated patients, and (2) Confirm the wild type status of p53 and analyze the functional status of p53 pathway by monitoring expression of selected p53-target genes in tumors in patients who have or have not been treated with 20 mg tamoxifen for four weeks prior to surgery. These studies will be conducted prospectively in newly diagnosed breast cancer patients (to be recruited to the Roswell park Cancer Institute over next two years) using a combination of clinical, pathological, cellular, and molecular biology expertise. The status of ER and p53, their interaction, and its consequences in breast tumors will be analyzed with immunohistochemical, cellular, and molecular approaches. This project brings in a paradigm shift to the way resistance to tamoxifen therapy had been addressed to-date. Results from the proposed studies should help to devise new methods to screen patients for tamoxifen therapy and also lead to the development of better diagnostic and intervention strategies. Our studies by providing clues to screen patients who would be benefited by tamoxifen therapy, will help to avoid unnecessary exposure of patients with tumors unresponsive to this drug with several unpleasant side effects. Therefore, our study should constitute an important step toward personalized breast cancer therapy aimed at maximum therapeutic benefit to the patient. Show more... | National Institutes of Health | 7/13/2009 |
| HEALTH RESEARCH, INC. | $145,399.00 | Grant | Trans-NIH Recovery Act Research Support While the positive association between socioeconomic status (SES) and health outcomes has been a consistent finding in health related research, the pathways that produce this association remain imperfectly understood. One pathway that has been hypothesized to be an important link between an individual's SES and their health outcomes are their patterns of health care navigation. While there has been some research on health care navigation and health outcomes in adults, research has not yet examined how these process impact pediatric cancer patients. We also do not know how parents' patterns of health care navigation after a serious pediatric diagnosis vary by race and SES. The goal of this study is to understand how parents' patterns of health care navigation after a child is diagnosed with cancer vary by race and SES, and to translate these findings into evidence based intervention programs. To accomplish this, the proposed study has three specific aims: 1) Conduct 80 in-depth interviews with parents of pediatric cancer patients to document the different characteristics of their patterns of health care navigation; 2) Collect and analyze data on the multiple dimensions of the SES construct to determine what elements of SES are theoretically important for key outcome variables; and 3) Use these data to inform the development of evidence-based, culturally sensitive intervention programs. This study will use a mixed methods approach, combining in-depth interviews with parents and care givers of children with cancer and survey data on socio-demographic variables and family functioning scales. These methods will allow for the collection of nuanced, rich data enabling the definition and understanding of parents' patterns of health care navigation after a child is diagnosed with cancer, and how these patterns vary by race and SES. Since there is not enough existing data to understand the relationship of race, SES, and navigational decisions and barriers of families of pediatric oncology patients, we are not able to do a hypothesis-driven study. This study will build foundational data to inform future research. Results from this study have the potential to make a significant theoretical and practical contribution to scholarship and intervention surrounding pediatric health disparities. Data will be used to define patterns of health care navigation, and identity signature elements of different patterns parents enact. Building upon preliminary data, results will be used to develop a theoretical framework that accounts for the ways that race and SES weave together to affect these patterns of health care navigation. Hypotheses derived from these findings will be tested in a future quantitative longitudinal study of the long term outcomes of pediatric cancer on patients and their families. Findings will also be used to inform the development of culturally sensitive intervention programs aimed to reduce the risks of adverse outcomes of cancer treatment on family members? well being. Show more... | National Institutes of Health | 6/05/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $230,464.00 | Grant | Trans-NIH Recovery Act Research Support The primary objective of the proposed research is to develop a rodent model of self administration (SA) in which drug consumption has delayed negative consequences. Self administration procedures in which the animals make responses that are reinforced by IV drug injections are widely used and are perhaps the most convincing non-human animal models of drug abuse. Non-human animal SA models, however, may not model important aspects of human drug SA. In humans, impulsivity is considered an important component of drug abuse because individuals take drugs despite the knowledge of negative (often delayed) outcomes associated with drug use. In contrast, standard laboratory animal models of SA have no explicit negative outcomes associated with the SA of the drug. Because there are currently no SA models that incorporate negative consequences, the impact of negative outcomes is not generally incorporated into current ideas about the underlying behavioral and neurobiological mechanisms mediating drug abuse. The goal of the Experiment 1 of this application is to determine a dose of cocaine and an amount of water that have equivalent reinforcing efficacy. In this application reinforcing efficacy is measured using progressive ratio schedules of reinforcement. In progressive ratio schedules, reinforcement efficacy is operationally defined as the break point (BP) which indicates the maximum number of responses an animal will make on a progressive ratio schedule of reinforcement for a given reinforcer. Determination of a dose of cocaine and an amount of water that have equivalent efficacy will insure that cocaine and water reinforcers of equivalent reinforcing efficacy are used In Experiments 2 and 3. Experiment 2 will determine if immediate shock has different effects on the reinforcing efficacy of drug and natural reinforcers using the progressive ratio schedule of reinforcement. Building upon Experiments 1 and 2, Experiment 3 will determine the effects of delaying the shock on the reinforcing efficacy of the cocaine/shock and water/shock reinforcers. These studies will advance to our understanding of drug abuse by determining if punishment or delays to punishment have similar (or dissimilar) effects on drug (cocaine) and natural (water) reinforcers of equivalent reinforcing efficacy. These results will help to determine if a 'punished' SA model is a valuable tool with which to investigate the behavioral and cognitive regulation of drug abuse by negative consequences. PUBLIC HEALTH RELEVANCE: The primary objective of the proposed research is to develop a rodent model of self administration (SA) in which drug consumption has delayed negative consequences. There is little doubt that non-human animal SA procedures model important aspects of drug taking in humans; however in some respects the typical application of this model in the laboratory does not model important aspects of drug consumption by human addicts. According to the Diagnostic and Statistical Manual of Mental Disorders (APA, 1994) an important characteristics of human drug addiction is continued drug intake despite harmful consequences. However, current non human animal models of drug abuse do not address this important issue. Consequently, the impact of negative outcomes is not generally incorporated into current ideas about the underlying behavioral and neurobiological mechanisms mediating drug abuse. We believe that drug abuse in humans is a function of two separate processes, 'rewarding' positive affective responses to the drug and 'impulsivity-related' factors, or influences that normally inhibit or limit the use of drugs. Development of a non human SA model that incorporates negative consequences will enhance research into 'impulsivity-related factors' that are necessary for drug abstinence Show more... | National Institutes of Health | 5/14/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $2,000,000.00 | Grant |
Trans-NIH Recovery Act Research Support Cardiovascular molecular imaging is a rapidly emerging area offering considerable promise for the evaluation of patients with heart and vascular disease. While proof of concept studies using novel imaging agents and micro PET have been conducted in mouse models of heart disease, their translation to humans and large animal models has been problematic since the human heart is 2000 times larger and dosimetry and tracer localization are considerably different. This proposal requests support to advance preclinical and clinical translational cardiovascular molecular imaging by acquiring a hybrid positron emission tomography (PET) and multidetector computed tomography (CT) scanner dedicated to research. It will support and enhance the ongoing investigational imaging programs of seven major users (supported by 9 RO1 awards and 2 K awards focused on cardiovascular imaging). The proposed GE Discovery VCT is a state of the art PET/CT scanner that will permit preclinical studies of vascular and myocardial structure coupled with molecular imaging using novel cyclotron generated radiopharmaceuticals developed at the adjacent UB Center for Positron Emission Tomography. The Center for Research in Cardiovascular Medicine and Toshiba Stroke Center at the University at Buffalo are interdisciplinary cardiovascular research centers that are recognized leaders in translational cardiovascular imaging. NIH supported studies routinely employ advanced cardiovascular imaging in porcine models of chronic ischemic heart disease and large animal models of stroke. Besides basic mechanistic research, active programs exist in therapeutics including vascular stents, in vivo gene transfer and cardiovascular repair with stem cells (mesenchymal stem cells and endothelial progenitor cells). There is also a large ongoing NIH supported clinical trial to determine if PET can predict the risk of sudden cardiac death in patients by quantifying the extent of hibernating myocardium and imaging inhomogeneity in sympathetic innervation using 11C-Hydroxyephedrine (Prediction of Arrhythmic Events with Positron Emission Tomography). The combined institutional expertise in large animal disease models including hibernating myocardium, coronary disease, cerebrovasular disease and ischemic cardiomyopathy along with patient oriented research in cardiac PET, quantitative image analysis and radiochemistry synthesis are unique strengths of this investigative team. The proposed instrument and synergy between these two teams will facilitate rapid advancements in the field of molecular imaging as applied to the cardiovascular system. PUBLIC HEALTH RELEVANCE: Heart disease continues to be one of the leading causes of death and disability. The proposed PET/CT system will advance bench to bedside research of potentially clinically relevant therapies by focusing on research at the preclinical to clinical translational interface. Such multilevel translational research ultimately has a high likelihood of directly impacting patient care and improving health outcomes. ` Show more...
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
National Institutes of Health | 4/28/2009 |
| HEALTH RESEARCH, INC. | $383,842.00 | Grant | Trans-NIH Recovery Act Research Support Mutation of the retinoblastoma tumor suppressor gene (Rb1) causes the pediatric cancer retinoblastoma and contributes to most types of human cancer. Despite its central role in tumorigenesis, therapies designed to target this pathway have been slow to develop. A detailed understanding of the molecular mechanisms underlying Rb1 mediated tumor suppression will facilitate the development of such therapies. The long-term goal of this continuing project is to identify and characterize these molecular mechanisms. Rb1 protein (pRb) is a negative regulator of the cell cycle, and this cell cycle regulatory activity contributes to tumor suppression. Multiple mechanisms likely contribute to pRb mediated cell cycle control, including the well characterized mechanism involving binding of pRb to E2F transcription factors resulting in transcriptional repression of genes required for cell cycle progression. Another possible mechanism involves targeted degradation of Skp2 by pRb and consequent stabilization of p27Kip1. The ability of pRb to regulate E2F transcription factors is genetically separable from its ability to degrade Skp2. We hypothesize that pRb mediated degradation of Skp2 and stabilization of p27Kip1 contributes to prostate tumor suppression in vivo. Our working model is that post translational stabilization of p27Kip1 (p27) normally enforces a senescence like response to oncogenic stress, thereby curtailing tumor initiation and progression. In the absence of pRb, this tumor suppressive response is muted. The goal of this application is to test the hypothesis using in vitro and in vivo experimental model systems. We have created a mouse strain containing a mutant Rb1 allele (R654W) whose encoded protein is deficient for E2F binding and regulation, but may be competent to target Skp2 for degradation. We propose to use this mutant allele to assess the relative contribution of the pRb/E2F and pRb/p27 mechanisms to prostate tumor suppression in vivo. Two specific aims are proposed: 1) Test whether R654W pRb can suppress prostate tumorigenesis in the mouse; 2) Characterize the contribution of the pRb/Skp2/p27 mechanism to R654W pRb tumor suppressor activity. Successful completion of these specific aims will identify a new mechanism contributing to Rb1 tumor suppression and suggest new therapeutic strategies to treat prostate cancer. Show more... | National Institutes of Health | 7/16/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $481,358.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 4/29/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $841,570.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 5/19/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $1,500,000.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 5/26/2009 |
| HEALTH RESEARCH, INC. | $100,000.00 | Grant | Trans-NIH Recovery Act Research Support Lung cancer is the most frequent cause of cancer death in both men and women in the United States. Lymph node staging provides the most important prognostic information in patients with loco-regional nonsmall cell lung cancer. The parent grant is involves using a radioguided, intra-operative, hand held gamma probe to detect lymph node metastases. It is currently difficult to predict which primary tumors will metastasize early, via the lymphatics. This supplemental grant seeks to provide the tools to study the molecular mechanisms of lymph node metastases. We hypothesize that expression of VEGF-A, VEGF-C and VEGF-D in primary tumors induces lymphoangiogenesis in tumors and their draining lymph nodes, resulting in lymph node metastases. A prospective cohort of patients with micro, macro and no lymph node metastasis from lung cancer provides a unique opportunity to study this concept in the basic science laboratory. With the knowledge of the molecular profiles of the tumors of the patients in our clinical trial, we can rationally design mechanistic studies. Understanding the molecular mechanisms of metastases in lymph nodes may guide the design of our appropriate therapeutic trials. Improvement in therapy resulting in better patient survival is the ultimate goal of radio-guided detection of lymph node metastases in non-small cell lung cancer. Show more... | National Institutes of Health | 9/23/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $68,339.00 | Grant | Trans-NIH Recovery Act Research Support Carbonyl reductase activity accounts for a significant fraction of the metabolism of pharmacological agents extensively used in clinical practice such as the antipsychotic haloperidol and the anticancer anthracyclines doxorubicin and daunorubicin. In humans there are two carbonyl reductases, carbonyl reductase 1 (CBR1) and carbonyl reductase 3 (CBR3). It is possible that genetic variability in CBR1 and CBR3 may be key for the wide person-to-person variation in the metabolism of drugs that are CBR substrates. A systematic approach that combines the identification of common CBR1 and CBH3 genetic variants together with functional studies will be needed to critically delineate the role of CBR1 and CBR3 in variable CBR mediated drug biotransformation. Towards this goal we investigated the presence of single nucleotide polymorphisms (SNPs) in CBR1 and CBR3. Two SNPs in CBR3 encoding for non-synonymous changes in the amino acidic sequence of the protein were pinpointed to perform functional characterization studies. One SNP encodes for a valine244 to methionine244 change (CBR3 V244M), while the other SNP results in a cysteine4 to tyrosine4 substitution (CBR3 C4Y). Interestingly, the CBR3 allelic variants are common among different ethnic groups. Very promising kinetic data suggest that the polymorphic CBR3 valine244 and CBR3 methionine244 protein isoforms have distinctive catalytic properties towards menadione and doxorubicin. Thus, studies in specific Aim 1 will focus on the functional characterization of the polymorphic CBR3 protein isoforms. In specific Aim 2 the effects of polymorphic CBR3 in hepatic CBR activity will be investigated using 200 paired DNA-RNA liver tissue samples. The presence of genotype-phenotype correlations will be analyzed by measuring variables such as enzyme activities and protein levels in samples with known CBR3 genotypes. An additional contributing factor for inter-individual CBR variability may be dictated by the presence of genetic polymorphisms in the regulatory CBR1 and CBR3 proximal promoter regions. In specific Aim 3, DNA samples from phenotypic CBR outliers (pinpointed in Aim2) will be screened to identify new polymorphisms in the thus far unexplored CBR1 and CBR3 proximal promoter regions. Subsequent to the determination of allele frequencies, the functional consequences of the novel allelic variants will be examined by DNA expression analysis using gene reporter assays. Collectively, the proposed studies will provide essential information on the impact of CBR1 and CBR3 genetic variability on CBR mediated drug metabolism. The understanding of the molecular basis that govern the pharmacodynamics of CBR metabolized drugs will assist the design of more rational pharmacological therapies. Show more... | National Institutes of Health | 9/18/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $39,625.00 | Grant | Trans-NIH Recovery Act Research Support Streptococcus mutans is the primary cariogen that produces several virulence factors. The long-term goal of the proposed studies is to characterize specific interactions of S. mutans with oral bacteria in the dental plaque biofilm. We hypothesize that it is not merely colonization by S. mutans that determines the ultimate cariogenicity of plaque, but the interaction of the pathogen with other biofilm bacteria that affect virulence. Other bacteria present in dental plaque may modulate quorum sensing-dependent expression of virulence properties of the organism. This hypothesis is based on observations that: 1) S. mutans competence-stimulating peptide (CSP) and a signal transduction system mediate a variety of virulence characteristics: biofilm formation, bacteriocin production, acid tolerance, antimicrobial sensitivity, and natural genetic transformation. Elimination of CSP or its signal transduction system results in alterations in all of these virulence activities. 2), other oral bacteria, such as the commensal early-colonizing dental plaque species Streptococcus gordonii, can inactivate S. mutans CSP thereby interfering with S. mutans bacteriocin production. Therefore, the experimental focus of this proposal will be to determine the effects of other early colonizers such as Actinomyces naeslundii and later anaerobic colonizers such as Porphyromonas gingivalis on quorum-sensing in S. mutans and to determine the effects of these organisms on the virulence-associated properties of S. mutans. The Specific Aims are: Specific Aim 1. To determine if early colonizers, S. gordonii or A. naeslundii, antagonize colonization efficiency and the acid tolerance response in S. mutans. i) Colonization of S. mutans WT and its comC mutant on preformed biofilms of S. gordonii Challis or A. naeslundii will be assessed by both radioactive labeling techniques and confocal microscopy. ii) The acid tolerance response of S. mutans and mixtures with S. gordonii Challis or A. naeslundii will be assessed by viable cell counts. Specific Aim 2. To determine if late colonizers such as P. gingivalis, Treponema denticola, and Tannerella forsythia antagonize quorum-sensing properties in S. mutans. i) S. mutans bacteriocin production in broth monocultures of S. mutans and mixtures of S. mutans with P. gingivalis, T. denticola, or T. forsythia will be monitored by determining killing percentages of an indicator strain. ii) The transformation efficiencies of S. mutans in monocultures and in mixtures with P. gingivalis, T. denticola, or T. forsythia will be assessed. iii) The acid tolerance response of S. mutans and mixtures with P. gingivalis, T. denticola, or T. forsythia will be assessed by viable cell counts. iv) We will determine if the proteinases of P. gingivalis inactivate the S. mutans CSP. Project Narrative: Dental caries is a common chronic infectious disease affecting much of the worldwide population. The S. mutans quorum-sensing system may be an appropriate target for interruption to reduce dental caries. The disruption of CSP-dependent regulation has the potential to attenuate the bacterium so that it is less virulent. Show more... | National Institutes of Health | 9/22/2009 |
| HEALTH RESEARCH, INC. | $181,655.00 | Grant | Trans-NIH Recovery Act Research Support The NCI has released the latest Common Terminology Criteria for Adverse Events version 4.0 (CTCAEv4.0). In order to collect and report on these new criteria, database table(s) will need to be created, the new criteria will need to be loaded, mappings from the prior version 3.0 are to be created, software to collect and report on the new criteria will be created or modified. Additionally, education materials will need to be created for our internal and external users on how to implement and interpret these new materials. Protocols GOG0241 and GOG0261 are the pilot protocols selected for use within the Clinical Trials Support Unit?s (CTSU) Oncology Patient Enrollment Network (OPEN) initiative. This will require working closely with CTSU staff to create a web portal between our two facilities to allow the registration of GOG patients. This will include the creation of new software and modifications to existing software. This will also require participation in conference calls and meetings sponsored by CTSU. Training materials will be developed to inform our internal and external users of this new system and how to implement this on GOG protocols. Additional work will be required to enter in and test eligibility criteria in the CTSU by our randomization and user support staff. The eCRF project will be to integrate the new eCRF standards into the GOG?s clinical trials infrastructure and to incorporate these new standards into the web based data entry system created at the SDC. The electronic Protocol Authoring (ePA) project will require participation on conference calls and meetings sponsored by CTEP during the selection process of various vendor?s products. Recently the NIC has select Medidata?s RAVE product for the electronic capture to clinical data. Once released to the Cooperative Groups, we will attend and participate on conference calls, meetings and discussion groups related to this endeavor. Show more... | National Institutes of Health | 9/18/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $1,242,226.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 4/08/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $826,561.00 | Grant | Highway Planning Highway Infrastructure Investment Grant: Urbanized | Federal Highway Administration | 3/19/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $1,561,000.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Urbanized
There were 3 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 7/01/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $800,000.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 2 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 5/19/2009 |
| TRANSPORTATION, NEW YORK DEPARTMENT OF | $567,090.00 | Grant |
Highway Planning Highway Infrastructure Investment Grant: Available
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Federal Highway Administration | 4/29/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $299,999.00 | Grant | Trans-NSF Recovery Act Research Support This award is funded under the American recovery and Reinvestment Act of 2009 (Public Law 111-5) The aim of this project is to develop new structural architectures for resisting and mitigating the effects of impulsive loadings, such as blast and high velocity impacts, using functionally graded protective systems. The research approach combines theoretical concepts from wave propagation and nonlinear dynamics with a heuristic optimization methodology, based on genetic algorithms, to develop protective systems that have spatially varying stiffness, density and damping. In particular, this research will investigate functionally graded material systems, along with strategically allocated voids and solid or fluid inclusions for the objective of attenuating stress waves imparted on a structural system by blast and high velocity impacts. The first phase of the research will feature the use of numerical simulations, within a parallel grid computing environment, to develop novel functionally graded protective system concepts. A rigorous experimental investigation will then validate the effectiveness of the proposed functionally graded protective systems for mitigating impulsive loads and provide feedback for further enhancements of these protective systems. The impact of the project will occur at several levels. The research will lead to the generation of new knowledge associated with functionally graded materials and systems, along with the development of robust optimization tools that rely on coupling genetic algorithm methodology with finite element analysis to tailor material architectures for mitigating blast and high velocity impact loading. The validated functionally graded protective systems will enable engineers to apply these new design concepts in structural systems vulnerable to blast and high velocity impact environment. Finally, this has the potential to transform the present design philosophy for structural design under blast and high velocity impacts from one that emphasizes hardening to one focused on energy and momentum management. The project involves the education and mentoring of at least one doctoral student, the research findings will be incorporated into several graduate level courses, including one specifically on blast engineering and a web-based repository will be established to enable broad dissemination of the research results. Show more... | National Science Foundation | 6/02/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $299,689.00 | Grant | Trans-NSF Recovery Act Research Support The main research objective of this award is the development of a framework for accurate estimation of tumor target dynamics which enables safe and effective Adaptive Conformal Radiation Therapy for cancer treatment. Two specific aims of this research are 1) construction of models correlating body surface motion to the motion of the tumor and 2) development of algorithms for state uncertainty characterization and propagation for timely acquisition of tumor motion data. The research approach progresses from the development of a simple rigid body point mass representation of the tumor, followed by a finite dimensional rigid body model and concluding with a model which accounts for the flexible modes of the tumor dynamics. In close collaboration with our project members from Roswell Park Cancer Institute (RPCI), comprehensive experiments will be performed in a clinical scenario to validate the developed framework. Deliverables include a suite of tumor motion models validated via lab experiments, algorithms for characterizing and propagating state uncertainty in tumor motion models, documentation of research results and undergraduate and graduate student education. If successful, this research has the potential to significantly improve the effectiveness of the conventional radiation therapy. This research will facilitate rational design of even more potent radiation treatment while minimizing: 1) exposure of healthy tissues to toxic radiations, 2) exposure to X-ray imaging doses and most importantly, 3) probability of relapse of tumor. This award facilitates collaboration between researchers in engineering and biomedical sciences. Through this kind of collaboration between two fields, expansion of the fundamental knowledge in both fields is expected. The goals of the broader impact portion of this award will be met in part by incorporating various aspects of the research program into educational activities as well. Show more... | National Science Foundation | 6/29/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $910,000.00 | Grant | Trans-NSF Recovery Act Research Support It will fund the research work of the High Energy Group at the State University of New York at Buffalo. The group main research activities are on the D0 experiment at the Tevatron, the CMS experiment at LHC, and the outreach program through QuarkNet. The research program plans to initially investigate the production of Standard Model processes and than to search for the Higgs particles at the CMS experiment. The background processes are important to themselves as they provide crucial test of the Standard Model in areas least explored so far. The group will continue its participation in the Forward Pixel Detector project. This participation should allow postdocs and graduate students to acquire a balanced education by combining activities of data analyses and detector commissioning and operation. The D0 detector has recorded in excess of 4fb-1 of data to date and is expected to substantially increase the integrated luminosity in the coming years. The goal of the proposed research program with D0 is to study Z decay to bbar and ZZ production processes. These analyses will greatly benefit from the increased dataset and well calibrated and understood detector. As for broader impact the research program will be fostering collaboration between the State University of New York at Buffalo group members, high school teachers and their students. They open Show more... | National Science Foundation | 6/05/2009 |
| INSTALLS INC, LLC | $440,000.00 | Contract | Basic In-home Digital converter box installation i | Federal Communications Commission | 5/02/2009 |
| INSTALLS INC, LLC | $800,000.00 | Contract | Basic In-home Digital converter box installation i | Federal Communications Commission | 5/15/2009 |
| INSTALLS INC, LLC | $420,000.00 | Contract | Basic In-home Digital converter box installation i | Federal Communications Commission | 5/02/2009 |
| ARSENAL CONTRACTING LLC | $1,875,000.00 | Contract |
Replace HVAC System in Bldg 92
There were 2 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Department of Veterans Affairs | 9/28/2009 |
| URS GROUP, INC. | $239,994.55 | Contract | TAS::96 3133::TAS BLANCHARD RIVER WATERSHED STUDY | Department of the Army | 7/08/2009 |
| INSTALLS INC, LLC | $350,000.00 | Contract | Basic In-home Digital converter box installation i | Federal Communications Commission | 5/02/2009 |
| INSTALLS INC, LLC | $148,995.00 | Contract | Expert In-home Digital converter box installation | Federal Communications Commission | 5/07/2009 |
| ARSENAL CONTRACTING LLC | $500,180.00 | Contract |
Demolition/Abatement of Buildings 6,7,11 and 35
There were 2 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Department of Veterans Affairs | 6/30/2009 |
| ARSENAL CONTRACTING LLC | $3,186,388.00 | Contract |
Provide all labor, materials , tools and equipment
There were 9 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Department of Veterans Affairs | 5/13/2009 |
| ECOLOGY AND ENVIRONMENT, INC. | $486,496.00 | Contract |
E & E will (1) develop an Engineering and Design Quality Control Plan; (2) provide A-E support for continuation of the Buffalo River Environmental Dredging Feasibility Study; (3) provide visualization and volume quantification of Dredged Sediments within the Buffalo River Project Area; (4) provide A-E Support of the USACE Regional Sediment Management (RSM) Authority (SEC 204) on the Buffalo River, New York; (5) provide A-E Support to the Great Lakes Fishery and Ecosystem Restoration (GLFER) Authority and develop a preliminary restoration plan; and (6) provide integrated Lower Maumee River -- Western Lake Erie Basin Modeling Support. Show more...
There were 1 sub-recipients, vendors, and/or sub-vendors associated with this. See details |
Department of Defense (except military departments) | 6/24/2009 |
| LUEDTKE ENGINEERING COMPANY | $1,173,750.00 | Contract | FY09 Maintenance Dredging Black Rock Channel Buffa | Department of the Army | 7/29/2009 |
| IROQUOIS BAR CORP. | $9,583.00 | Contract | Supply ready mix concrete | Department of the Army | 8/27/2009 |
| INSTALLS INC, LLC | $99,000.00 | Contract | Expert In-home Digital converter box installation | Federal Communications Commission | 5/07/2009 |
| ESENSORS INC | $89,978.00 | Contract | SBIR Time Synchronization of Wireless Sensor Netwo | National Institute of Standards and Technology | 6/19/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $199,999.00 | Contract | The purpose of this contract is to obtain services for the Student/Resident Experiences and Rotations in Community Health (SEARCH) program(s) to provide opportunities for health professions students and residents to serve on multidisciplinary health care teams in underserved communities throughout the United States and its territories, thereby establishing and strengthening links between community-based sites and academic institutions. The goals of the SEARCH program are to: 1) assist the Health Resources and Services Administration HRSA) Bureau of Clinician Recruitment and Services (BCRS) with its recruitment and the retention efforts of health care professionals for primary health care service; and 2) facilitate and strengthen partnerships between communities and academic institutions (community-academic linkages). In order to accomplish these goals, SEARCH will: 1) provide opportunities for students to implement their classroom experiences in a health care setting; 2) provide opportunities for students and residents to train on multidisciplinary primary health care teams; 3) nurture the development of culturally competent, community focused primary and allied health care providers; and 4) expand statewide partnerships including the State Primary Care Association (PCAs), State Primary Care Office (PCOs), Office of Rural Health (ORHs), professional associations, academic institutions, and Area Health Education Centers (AHECs) to form a network of organizations to meet the diverse primary care needs of the underserved. Show more... | Health Resources and Services Administration | 9/29/2009 |
| INSTALLS INC, LLC | $400,000.00 | Contract | Basic In-home Digital converter box installation i | Federal Communications Commission | 5/02/2009 |
| INSTALLS INC, LLC | $148,500.00 | Contract | Expert In-home Digital converter box installation | Federal Communications Commission | 5/07/2009 |
| BOSTON,TOWN | $3,006,000.00 | Loan | TOA Code 538, Water only loan only - Rural Development funds will be used to install water lines consisting of 35,200 linear feet of pipe and 33 fire hydrants. The project will replace unhealthy wells to improve water quality and service as well as improve fire protection. The project will benefit 453 users. Show more... | Rural Utilities Service | 6/30/2009 |
| MARILLA, TOWN OF | $967,000.00 | Loan | TOA Code 544, Water only combo loan/grant - Rural Development funds will be used to install 15,000 feet of PVC pipe with one large and three small creek crossings to improve water for residents in the area who are experiencing insufficient quantity and poor water quality. The project will benefit 148 users. Show more... | Rural Utilities Service | 9/04/2009 |
| BOSTON,TOWN | $197,000.00 | Loan | TOA Code 544, Water only combo loan/grant - Rural Development funds will be used to install a water main and a booster pumping station in order to provide safe, clean drinking water to residents who currently rely on unhealthy wells. The project will benefit 13 users. | Rural Utilities Service | 6/30/2009 |
| AFFINITY OLD POST L P | $210,777.00 | Grant | Section 8 Housing Assistance Payments Program Special Allocations (Recover Contract Svs S8 Funds | Dept of Housing and Urban dev | 3/20/2009 |
| AUTUMN WOODS ASSOCIATES L.P. | $1,355,354.00 | Grant | Section 8 Housing Assistance Payments Program Special Allocations (Recover Contract Svs S8 Funds | Dept of Housing and Urban dev | 3/25/2009 |
| BENCHMARK CEDAR RIDGE ELDERLY TOWER | $270,875.00 | Grant | Section 8 Housing Assistance Payments Program Special Allocations (Recover Contract Svs S8 Funds | Dept of Housing and Urban dev | 3/20/2009 |
| BENCHMARK WINTON HOUSE ASSC | $167,040.00 | Grant | Section 8 Housing Assistance Payments Program Special Allocations (Recover Contract Svs S8 Funds | Dept of Housing and Urban dev | 3/20/2009 |
| BOARD COOPERATIVE EDUCTL SVCS | $81,860.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 5/14/2009 |
| BOARD COOPERATIVE EDUCTL SVCS | $9,271.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 5/13/2009 |
| BRYANT & STRATTON COLLEGE INC | $10,395,664.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 5/14/2009 |
| BRYANT & STRATTON COLLEGE INC | $1,177,403.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 5/13/2009 |
| BRYANT & STRATTON COLLEGE INC | $11,169.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 4/23/2009 |
| BRYANT & STRATTON COLLEGE INC | $10,539.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 4/24/2009 |
| BRYANT & STRATTON COLLEGE INC | $6,999.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 4/07/2009 |
| BRYANT & STRATTON COLLEGE INC | $6,532.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 5/12/2009 |
| BRYANT & STRATTON COLLEGE INC | $4,731.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 4/15/2009 |
| BRYANT & STRATTON COLLEGE INC | $4,709.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 4/28/2009 |
| BRYANT & STRATTON COLLEGE INC | $4,139.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 4/22/2009 |
| BRYANT & STRATTON COLLEGE INC | $2,527.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 5/05/2009 |
| BRYANT & STRATTON COLLEGE INC | $2,365.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 4/14/2009 |
| BRYANT & STRATTON COLLEGE INC | $-251.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 4/20/2009 |
| BRYANT & STRATTON COLLEGE INC | $-255.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 5/08/2009 |
| BRYANT & STRATTON COLLEGE INC | $-590.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 4/27/2009 |
| BRYANT & STRATTON COLLEGE INC | $-592.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 4/21/2009 |
| BRYANT & STRATTON COLLEGE INC | $-12,757.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 4/30/2009 |
| BRYANT & STRATTON COLLEGE INC | $-22,839.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 5/18/2009 |
| CANISIUS COLLEGE OF BUFFALO | $900,593.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 5/14/2009 |
| CANISIUS COLLEGE OF BUFFALO | $102,000.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 5/13/2009 |
| CEDAR GROVE HEIGHTS | $11,592.00 | Grant | Section 8 Housing Assistance Payments Program Special Allocations (Recover Contract Svs S8 Funds | Dept of Housing and Urban dev | 3/20/2009 |
| THE CLAREMOUNT | $289,406.00 | Grant | Section 8 Housing Assistance Payments Program Special Allocations (Recover Contract Svs S8 Funds | Dept of Housing and Urban dev | 6/25/2009 |
| DAEMEN COLLEGE | $639,199.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 5/14/2009 |
| DAEMEN COLLEGE | $72,395.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 5/13/2009 |
| DAEMEN COLLEGE | $8,762.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 4/28/2009 |
| DAEMEN COLLEGE | $7,096.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 4/30/2009 |
| DAEMEN COLLEGE | $1,790.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 4/22/2009 |
| DAEMEN COLLEGE | $1,043.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 4/09/2009 |
| DAEMEN COLLEGE | $787.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 4/21/2009 |
| DAEMEN COLLEGE | $0.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 5/14/2009 |
| DAEMEN COLLEGE | $-1,043.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 4/16/2009 |
| DYOUVILLE COLLEGE | $635,200.00 | Grant | PELL GRANT PROGRAM | Department of Education | 5/14/2009 |
| DYOUVILLE COLLEGE | $71,942.00 | Grant | PELL GRANT PROGRAM | Department of Education | 5/13/2009 |
| ELLICOTT COMMUNITY REDEVOLP. | $618,735.00 | Grant | Section 8 Housing Assistance Payments Program Special Allocations (Recover Contract Svs S8 Funds | Dept of Housing and Urban dev | 9/25/2009 |
| ERIE COMMUNITY COLLEGE | $6,458,611.00 | Grant | PELL GRANT PROGRAM | Department of Education | 5/14/2009 |
| ERIE COMMUNITY COLLEGE | $731,496.00 | Grant | PELL GRANT PROGRAM | Department of Education | 5/13/2009 |
| ERIE COMMUNITY COLLEGE | $132,966.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 4/07/2009 |
| ERIE COMMUNITY COLLEGE | $81,895.00 | Grant | PELL GRANT PROGRAM | Department of Education | 5/11/2009 |
| ERIE COMMUNITY COLLEGE | $2,197.00 | Grant | PELL GRANT PROGRAM | Department of Education | 5/15/2009 |
| ERIE COMMUNITY COLLEGE | $0.00 | Grant | PELL GRANT PROGRAM | Department of Education | 5/01/2009 |
| ERIE COMMUNITY COLLEGE | $0.00 | Grant | PELL GRANT PROGRAM | Department of Education | 4/30/2009 |
| ERIE COMMUNITY COLLEGE | $-4,280.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 4/16/2009 |
| HERBERT STAR APTS. | $104,958.00 | Grant | Section 8 Housing Assistance Payments Program Special Allocations (Recover Contract Svs S8 Funds | Dept of Housing and Urban dev | 3/20/2009 |
| HILBERT COLLEGE | $438,948.00 | Grant | PELL GRANT PROGRAM | Department of Education | 5/14/2009 |
| HILBERT COLLEGE | $49,715.00 | Grant | PELL GRANT PROGRAM | Department of Education | 5/13/2009 |
| HILBERT COLLEGE | $10,978.00 | Grant | PELL GRANT PROGRAM | Department of Education | 5/11/2009 |
| ISLANDVIEW HOUSING DEVELOPMENT | $238,368.00 | Grant | Section 8 Housing Assistance Payments Program Special Allocations (Recover Contract Svs S8 Funds | Dept of Housing and Urban dev | 3/20/2009 |
| KEN-TON PRESBYTERIAN E | $923,484.00 | Grant | Section 8 Housing Assistance Payments Program Special Allocations (Recover Contract Svs S8 Funds | Dept of Housing and Urban dev | 3/20/2009 |
| LEON STUDIO ONE SCHOOL HAIR | $52,137.00 | Grant | PELL GRANT PROGRAM | Department of Education | 5/14/2009 |
| LEON STUDIO ONE SCHOOL HAIR | $5,905.00 | Grant | PELL GRANT PROGRAM | Department of Education | 5/13/2009 |
| LEON STUDIO ONE SCHOOL HAIR | $5,337.00 | Grant | PELL GRANT PROGRAM | Department of Education | 5/14/2009 |
| LEON STUDIO ONE SCHOOL HAIR | $4,656.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 4/16/2009 |
| LEON STUDIO ONE SCHOOL HAIR | $4,422.00 | Grant | PELL GRANT PROGRAM | Department of Education | 4/23/2009 |
| LEON STUDIO ONE SCHOOL HAIR | $3,942.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 4/09/2009 |
| LEON STUDIO ONE SCHOOL HAIR | $2,366.00 | Grant | PELL GRANT PROGRAM | Department of Education | 4/20/2009 |
| LEON STUDIO ONE SCHOOL HAIR | $2,365.00 | Grant | PELL GRANT PROGRAM | Department of Education | 4/24/2009 |
| LESURETIMER'S RES SVC | $91,663.00 | Grant | Section 8 Housing Assistance Payments Program Special Allocations (Recover Contract Svs S8 Funds | Dept of Housing and Urban dev | 5/26/2009 |
| LEWIN BROTHERS, INC. | $15,312.00 | Grant | Section 8 Housing Assistance Payments Program Special Allocations (Recover Contract Svs S8 Funds | Dept of Housing and Urban dev | 3/20/2009 |
| MARJON SCHOOL OF BUTY CULTURE | $56,082.00 | Grant | PELL GRANT PROGRAM | Department of Education | 5/14/2009 |
| MARJON SCHOOL OF BUTY CULTURE | $6,352.00 | Grant | PELL GRANT PROGRAM | Department of Education | 5/13/2009 |
| MARJON SCHOOL OF BUTY CULTURE | $3,156.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 4/15/2009 |
| MARJON SCHOOL OF BUTY CULTURE | $3,006.00 | Grant | PELL GRANT PROGRAM | Department of Education | 5/07/2009 |
| MARJON SCHOOL OF BUTY CULTURE | $2,366.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 4/07/2009 |
| MARJON SCHOOL OF BUTY CULTURE | $2,366.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 4/13/2009 |
| MARJON SCHOOL OF BUTY CULTURE | $2,366.00 | Grant | PELL GRANT PROGRAM | Department of Education | 5/08/2009 |
| MARJON SCHOOL OF BUTY CULTURE | $2,366.00 | Grant | PELL GRANT PROGRAM | Department of Education | 4/23/2009 |
| MARJON SCHOOL OF BUTY CULTURE | $2,341.00 | Grant | PELL GRANT PROGRAM | Department of Education | 5/13/2009 |
| MEDAILLE COLLEGE | $661,734.00 | Grant | PELL GRANT PROGRAM | Department of Education | 5/14/2009 |
| MEDAILLE COLLEGE | $74,947.00 | Grant | PELL GRANT PROGRAM | Department of Education | 5/13/2009 |
| MEDAILLE COLLEGE | $63,115.00 | Grant | PELL GRANT PROGRAM | Department of Education | 5/15/2009 |
| MEDAILLE COLLEGE | $27,271.00 | Grant | PELL GRANT PROGRAM | Department of Education | 4/14/2009 |
| Neighborhood Legal Services | $221,131.00 | Grant | SSA- Work Incentives Planning and Assistance Program Western New York Social Security Work Incentives P | Social Security Administration | 3/31/2009 |
| NEW YORK INSTITUTE MASSAGE INC | $61,963.00 | Grant | PELL GRANT PROGRAM | Department of Education | 5/14/2009 |
| NEW YORK INSTITUTE MASSAGE INC | $9,289.00 | Grant | PELL GRANT PROGRAM | Department of Education | 4/22/2009 |
| NEW YORK INSTITUTE MASSAGE INC | $7,642.00 | Grant | PELL GRANT PROGRAM | Department of Education | 4/24/2009 |
| NEW YORK INSTITUTE MASSAGE INC | $7,018.00 | Grant | PELL GRANT PROGRAM | Department of Education | 5/13/2009 |
| NEW YORK INSTITUTE MASSAGE INC | $4,257.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 4/13/2009 |
| NEW YORK INSTITUTE MASSAGE INC | $2,365.00 | Grant | PELL GRANT PROGRAM | DEPARTMENT OF EDUCATION | 4/09/2009 |
| RENEWAL HOUSING CORP | $831,649.00 | Grant | Section 8 Housing Assistance Payments Program Special Allocations (Recover Contract Svs S8 Funds | Dept of Housing and Urban dev | 3/20/2009 |
| ST ANDREWS TOWERS | $1,684,800.00 | Grant | Section 8 Housing Assistance Payments Program Special Allocations (Recover Contract Svs S8 Funds | Dept of Housing and Urban dev | 5/11/2009 |
| ST JOHN TOWER/JAMES MANAGEMENT CO. | $219,240.00 | Grant | Section 8 Housing Assistance Payments Program Special Allocations (Recover Contract Svs S8 Funds | Dept of Housing and Urban dev | 3/20/2009 |
| TRANSITIONAL SERVICES | $10,657.00 | Grant | Section 8 Housing Assistance Payments Program Special Allocations (Recover Contract Svs S8 Funds | Dept of Housing and Urban dev | 3/20/2009 |
| TROCAIRE COLLEGE | $639,012.00 | Grant | PELL GRANT PROGRAM | Department of Education | 5/14/2009 |
| TROCAIRE COLLEGE | $72,374.00 | Grant | PELL GRANT PROGRAM | Department of Education | 5/13/2009 |
| TROCAIRE COLLEGE | $1,604.00 | Grant | PELL GRANT PROGRAM | Department of Education | 5/11/2009 |
| VILLA MARIA COLLEGE OF BUFFALO | $269,724.00 | Grant | PELL GRANT PROGRAM | Department of Education | 5/14/2009 |
| VILLA MARIA COLLEGE OF BUFFALO | $30,549.00 | Grant | PELL GRANT PROGRAM | Department of Education | 5/13/2009 |
| VILLA MARIA COLLEGE OF BUFFALO | $591.00 | Grant | PELL GRANT PROGRAM | Department of Education | 4/30/2009 |
| Abbott Motors, Inc | $200,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 4/03/2009 |
| Aduo, Inc. | $100,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 5/12/2009 |
| Advan-Tech Acquisition Inc | $170,000.00 | Loan | 504 TO ASSIST SMALL BUSINESS CONCERNS BY PROVIDING LON | Small Business Administration | 9/10/2009 |
| Advan-Tech Acquisition Inc. | $444,060.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 9/01/2009 |
| Akron Animal Hospital P.C. | $360,000.00 | Loan | 504 TO ASSIST SMALL BUSINESS CONCERNS BY PROVIDING LON | Small Business Administration | 8/17/2009 |
| Alliance Assistance, Ltd. | $25,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/13/2009 |
| Amton Auto and Truck, Inc | $202,500.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/10/2009 |
| Aries Computer Solutions Inc | $20,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 6/19/2009 |
| Aspire Family Dentistry Buffalo PLLC | $184,000.00 | Loan | 504 TO ASSIST SMALL BUSINESS CONCERNS BY PROVIDING LON | Small Business Administration | 8/05/2009 |
| Aspire Family Dentistry Buffalo PLLC | $266,000.00 | Loan | 504 TO ASSIST SMALL BUSINESS CONCERNS BY PROVIDING LON | Small Business Administration | 8/05/2009 |
| Aurora Audiology & Speech Associates In | $241,000.00 | Loan | 504 TO ASSIST SMALL BUSINESS CONCERNS BY PROVIDING LON | Small Business Administration | 5/29/2009 |
| Aurora Audiology & Speech Associates In | $27,000.00 | Loan | 504 TO ASSIST SMALL BUSINESS CONCERNS BY PROVIDING LON | Small Business Administration | 9/21/2009 |
| THE AURORA BIKE SHOP, INC. | $25,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 5/13/2009 |
| Be Relevant Group LLC | $30,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 5/12/2009 |
| Bella Capelli of Aurora, LLC | $58,500.00 | Loan | 7A PATRIOT EXPRESS | Small Business Administration | 6/18/2009 |
| Bella Capelli of Aurora, LLC | $-6,750.00 | Loan | 7A PATRIOT EXPRESS | Small Business Administration | 7/06/2009 |
| BENEFIT BROKERS OF WNY, LLC | $45,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 9/21/2009 |
| Best Tan of NY, Inc. | $25,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/04/2009 |
| Best Vision, Inc. | $25,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/04/2009 |
| Betty's | $64,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 4/06/2009 |
| THE BIKER BAZAAR | $-88,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 5/29/2009 |
| THE BIKER BAZAAR | $88,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 4/21/2009 |
| The Biker Bazaar | $63,000.00 | Loan | 7A PATRIOT EXPRESS | Small Business Administration | 7/22/2009 |
| Boston, Town of | $0.00 | Loan | Direct Water & Waste Disposal Positive Subsidy | Rural Utilities Service (15) | 6/30/2009 |
| Boston, Town of | $0.00 | Loan | Direct Water & Waste Disposal Positive Subsidy | Rural Utilities Service (15) | 6/30/2009 |
| Boston, Town of | $3,006,000.00 | Loan | Direct Domestic Water Loans - 09/10 Stimulus - Pub | Rural Utilities Service (15) | 6/30/2009 |
| Boston, Town of | $197,000.00 | Loan | Direct Domestic Water Loans - 09/10 Stimulus - Pub | Rural Utilities Service (15) | 6/30/2009 |
| Botanicus Inc. | $220,000.00 | Loan | 504 TO ASSIST SMALL BUSINESS CONCERNS BY PROVIDING LON | Small Business Administration | 9/18/2009 |
| Brian Parisi Copier Systems, Inc. | $35,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/18/2009 |
| Brian Parisi Copier Systems Inc. | $291,000.00 | Loan | 504 TO ASSIST SMALL BUSINESS CONCERNS BY PROVIDING LON | Small Business Administration | 9/12/2009 |
| Britica Management Group, Inc. | $50,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 3/04/2009 |
| Bruce J. Hora | $115,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 6/17/2009 |
| Buerk Tool LLC | $225,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/04/2009 |
| Buffalo Auto Rental Inc | $25,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 7/14/2009 |
| Buffalo Buck's Smokehouse Restaurant | $20,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 7/29/2009 |
| Buffalo Compressed Air | $72,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 4/29/2009 |
| Buffalo Discount Muffler & Brake | $124,000.00 | Loan | 504 TO ASSIST SMALL BUSINESS CONCERNS BY PROVIDING LON | Small Business Administration | 9/24/2009 |
| Buffalo Training Center LLC | $12,500.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/27/2009 |
| C & G Group of WNY, LLC | $33,800.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 5/04/2009 |
| C & G Group of WNY, LLC | $25,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 5/04/2009 |
| Calhoun EyeCare & Optometry PC | $145,000.00 | Loan | 504 TO ASSIST SMALL BUSINESS CONCERNS BY PROVIDING LON | Small Business Administration | 9/16/2009 |
| Canfield's Landscaping | $25,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 4/08/2009 |
| The Carey Firm LLC | $135,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 9/28/2009 |
| Carrollco, LLC | $205,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 4/06/2009 |
| Cats Like Us, LLC | $27,500.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 7/14/2009 |
| CIR ELECTRICAL CONSTRUCTION CORP | $247,500.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 9/01/2009 |
| CIR ELECTRICAL CONSTRUCTION CORP | $334,530.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 9/01/2009 |
| Construction Personnel Group Inc. | $100,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/13/2009 |
| Conway Porter, C.P.A., P.C. | $65,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 4/01/2009 |
| Copper & Slate Inc | $25,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 3/04/2009 |
| Corto Brothers II, Inc | $175,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 5/29/2009 |
| Cozy Fireplace Company Inc. | $51,000.00 | Loan | 504 TO ASSIST SMALL BUSINESS CONCERNS BY PROVIDING LON | Small Business Administration | 9/26/2009 |
| Creative Comfort Systems, Inc. dba Reimer | $50,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 4/02/2009 |
| Creative Comfort Systems, Inc. dba Reimer | $68,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 4/02/2009 |
| Custom Built Displays Inc | $50,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 9/02/2009 |
| Custom Built Displays Inc | $50,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 9/02/2009 |
| D & J BRAWDY FARMS INC | $0.00 | Loan | DIRECT OPERATING LOAN SUBSIDY | Farm Service Agency (FA) | 3/05/2009 |
| D & J BRAWDY FARMS INC | $0.00 | Loan | DIRECT OPERATING LOAN SUBSIDY | Farm Service Agency (FA) | 3/05/2009 |
| D & J BRAWDY FARMS INC | $100,000.00 | Loan | DIRECT OPERATING LOAN | Farm Service Agency (FA) | 3/05/2009 |
| D & J BRAWDY FARMS INC | $100,000.00 | Loan | DIRECT OPERATING LOAN | Farm Service Agency (FA) | 3/05/2009 |
| D. Jones Electric, Inc. d/b/a Tunney Elec | $150,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 7/07/2009 |
| David M. Gordon | $900,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 9/11/2009 |
| Davidson Restaurant Group Inc | $54,500.00 | Loan | 7A PATRIOT EXPRESS | Small Business Administration | 4/20/2009 |
| Dennis Evchich Agency, Inc. | $90,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 5/21/2009 |
| Dip 'N Dive Inc | $25,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 3/31/2009 |
| Durkin Heating and Cooling, Inc | $25,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 4/20/2009 |
| Edward P. O'Brien, MD | $225,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/25/2009 |
| Ella Perry Medical, P.C. | $-12,500.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 9/10/2009 |
| Ella Perry Medical, P.C. | $-12,500.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 9/09/2009 |
| Emerling International Foods, Inc. | $225,000.00 | Loan | 7A PATRIOT EXPRESS | Small Business Administration | 7/07/2009 |
| Eminent Technology Solutions Inc | $37,500.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/06/2009 |
| Empire Smokes, Inc. & Lorenz Holdings, Inc | $46,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 4/15/2009 |
| Enhanced Tool Inc | $90,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/17/2009 |
| Environmental Education Associates, Inc. | $99,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 4/27/2009 |
| Flexo Transparent Inc. | $758,000.00 | Loan | 504 TO ASSIST SMALL BUSINESS CONCERNS BY PROVIDING LON | Small Business Administration | 6/17/2009 |
| G.A.D. Enterprises, Inc. | $50,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 5/11/2009 |
| GENESIS CHIROPRACTIC | $440,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 3/03/2009 |
| Good & Fair Carting & Moving Co., Inc | $0.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 4/07/2009 |
| Good & Fair Carting & Moving Co., Inc | $75,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 3/24/2009 |
| Gordon Companies, Inc. | $600,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 9/11/2009 |
| Graphcon, Inc. | $30,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 6/25/2009 |
| Great Expectations Childcare, Inc | $30,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 7/28/2009 |
| Great Lakes Medical Sales LLC | $50,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 2/24/2009 |
| Hamburg Cycle, Inc | $37,500.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 9/22/2009 |
| Hamburg Floor Covering Inc. | $100,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 5/13/2009 |
| HAMBURG FLOOR COVERING INC. AND TODD D. CZ | $66,600.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 6/11/2009 |
| Hive Lifespan Center, Inc. | $200,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 4/13/2009 |
| Ievolve Inc | $250,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 3/30/2009 |
| Imperial Wholesale Inc. | $263,000.00 | Loan | 504 TO ASSIST SMALL BUSINESS CONCERNS BY PROVIDING LON | Small Business Administration | 5/04/2009 |
| Infinite Health Chiropractic and Wellness | $12,500.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/12/2009 |
| Infinite Health Chiropractic and Wellness | $21,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/12/2009 |
| Innovative Recovery Group, Inc. | $100,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 4/24/2009 |
| International Spirits, LLC | $150,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 2/27/2009 |
| International Spirits, LLC | $25,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 2/27/2009 |
| Ivy Lea Construction, Inc. | $100,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 7/02/2009 |
| James Shanor, Kathleen Shanor, Daniel Welc | $116,200.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 4/14/2009 |
| J. D. Cousins, Inc. | $150,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/06/2009 |
| John Eberz (P.C. entity to be formed) | $12,500.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/13/2009 |
| John Eberz (Real Estate entity to be forme | $265,500.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/13/2009 |
| JOHNNY ROCKETS | $225,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 6/12/2009 |
| K Feather 5, LLC dba Duff's on Dick | $75,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 7/01/2009 |
| Kelly M. Truong, DDS | $162,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 3/06/2009 |
| KEN-TON FABRICATORS, INC. | $225,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/12/2009 |
| Kishel's Quality Animal Scents & Lures, In | $12,500.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 6/15/2009 |
| La Tolteca | $375,000.00 | Loan | 504 TO ASSIST SMALL BUSINESS CONCERNS BY PROVIDING LON | Small Business Administration | 6/18/2009 |
| Lackawanna Chiropractic | $74,250.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 7/01/2009 |
| Lackawanna Chiropractic | $114,750.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 7/01/2009 |
| Lake Shore Truck & Trailer Inc | $50,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 4/08/2009 |
| LGGC Inc | $135,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 7/21/2009 |
| M Efthemis & Associates | $30,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 4/16/2009 |
| Marilla, Town of | $0.00 | Loan | Direct Water & Waste Disposal Positive Subsidy | Rural Utilities Service (15) | 9/04/2009 |
| Marilla, Town of | $967,000.00 | Loan | Direct Domestic Water Loans - Public Body - 09/10 | Rural Utilities Service (15) | 9/04/2009 |
| MCCLELLAND SMALL ANIMAL HOSPITAL, P.C. | $38,500.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 9/09/2009 |
| MCD Plumbing, Inc. | $150,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 3/10/2009 |
| Metal Preparations Company, Inc | $25,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/14/2009 |
| Michael C. Casseri Agency | $67,500.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 6/12/2009 |
| Mike Telesco Design Inc | $12,500.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/25/2009 |
| Mobile Ultrasound of WNY LLC | $15,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 9/04/2009 |
| Moore Road Construction, Inc. | $80,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 4/09/2009 |
| Moore Road Construction, Inc. | $25,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/03/2009 |
| Ms. Jean's Child Care | $60,250.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 7/02/2009 |
| MVP DEVELOPMENT, INC. | $-18,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 9/17/2009 |
| MVP DEVELOPMENT, INC. | $220,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 4/03/2009 |
| Neville Manufacturing, Service and Distrib | $50,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 9/09/2009 |
| NORAZZA, INC. | $675,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/06/2009 |
| The Perfect Gift New York, Inc. | $155,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 3/12/2009 |
| Phoenix Physical Therapy Services PC | $25,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 3/27/2009 |
| Phoenix Physical Therapy Services PC | $25,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 3/04/2009 |
| Phoenix Physical Therapy Services PC | $-25,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 3/20/2009 |
| Pines Lawn and Garden, Inc. | $25,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 3/27/2009 |
| Pioneer Printwear, Inc. | $25,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/24/2009 |
| Pioneer Printwear, Inc. | $58,250.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/24/2009 |
| Proficiency Placement LLC | $25,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 5/28/2009 |
| QMC Technologies, Inc | $110,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 4/23/2009 |
| Q.T.A. Machining Inc. | $355,000.00 | Loan | 504 TO ASSIST SMALL BUSINESS CONCERNS BY PROVIDING LON | Small Business Administration | 5/21/2009 |
| Quality Bindery Services, Inc | $45,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 6/15/2009 |
| R.A.C. Property Maintenance Inc. | $50,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 3/19/2009 |
| Rapid Title Services Inc | $12,500.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 7/08/2009 |
| Risa's Deli and Catering Co. Inc. | $60,750.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 9/23/2009 |
| R.J. Joba, O.D.,P.C. | $25,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 6/09/2009 |
| RP Mechanical | $85,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 9/02/2009 |
| S & G Trucking Inc | $54,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 4/09/2009 |
| Sam I Am Enterprises, Inc | $25,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/20/2009 |
| SANCHACK, LLC | $25,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 3/20/2009 |
| S.E.G. Construction, Inc | $25,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 3/16/2009 |
| Seth Allen Company, Inc. | $12,500.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/05/2009 |
| Sheridan Soft Water Service Company Inc. | $57,500.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 6/10/2009 |
| Skidmore Inc. | $164,000.00 | Loan | 504 TO ASSIST SMALL BUSINESS CONCERNS BY PROVIDING LON | Small Business Administration | 6/08/2009 |
| Solmac, Inc. | $350,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 4/30/2009 |
| Specialty Maintenance Services, Inc | $50,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 9/14/2009 |
| Springville, Village of | $0.00 | Loan | Direct Water & Waste Disposal Positive Subsidy | Rural Utilities Service (15) | 7/27/2009 |
| Springville, Village of | $3,000,000.00 | Loan | Direct Waste Disposal Loans - 09/10 Stimulus - Pub | Rural Utilities Service (15) | 7/27/2009 |
| Steaks of Buffalo, Inc. | $150,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 4/20/2009 |
| Superior Heat Company LLC | $175,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/24/2009 |
| Survey Services Inc | $142,500.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 7/22/2009 |
| Tammy M E Perison, DDS | $414,900.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 6/18/2009 |
| Theodore G. Campas | $144,000.00 | Loan | 7A PATRIOT EXPRESS | Small Business Administration | 8/05/2009 |
| THOMAS E. DOUGHERTY, MD | $-1,000.00 | Loan | 504 TO ASSIST SMALL BUSINESS CONCERNS BY PROVIDING LON | Small Business Administration | 4/16/2009 |
| THOMAS E. DOUGHERTY, MD | $121,000.00 | Loan | 504 TO ASSIST SMALL BUSINESS CONCERNS BY PROVIDING LON | Small Business Administration | 2/27/2009 |
| THOMAS E. DOUGHERTY, MD | $-120,000.00 | Loan | 504 TO ASSIST SMALL BUSINESS CONCERNS BY PROVIDING LON | Small Business Administration | 7/08/2009 |
| Thomas H McCarthy Funeral Home Inc | $15,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/28/2009 |
| Tim Andruschat, Esq. | $12,500.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 9/09/2009 |
| Tim Andruschat, Esq. | $37,500.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 9/10/2009 |
| Timothy Lafferty | $15,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 9/28/2009 |
| Toscana Salon and Day Spa Ltd. | $15,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/20/2009 |
| Tracys Retreat | $34,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/27/2009 |
| Urban Surfer, Inc. | $50,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 4/13/2009 |
| Varecka Builders, Inc. | $75,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 4/09/2009 |
| Varecka Builders, Inc. | $-35,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 4/17/2009 |
| Vascuscript, Inc. | $100,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 5/14/2009 |
| Vega Exclusive, Inc. | $12,500.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 9/25/2009 |
| Village Auto | $15,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/05/2009 |
| WBG Enterprises, Inc. | $405,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 6/23/2009 |
| W.H. Jones & Son, Inc. | $50,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 9/24/2009 |
| Winning Smiles Pediatric Dentistry, PLLC | $535,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 4/01/2009 |
| WSSN LLC | $385,000.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 4/29/2009 |
| Yup Chagi, Inc. | $27,500.00 | Loan | 7A TO AID SMALL BUSINESSES WHICH ARE UNABLE TO OBTAIN | Small Business Administration | 8/03/2009 |
| MULTIPLE RECIPIENTS | $0.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 9/30/2009 |
| MULTIPLE RECIPIENTS | $0.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 3/31/2009 |
| MULTIPLE RECIPIENTS | $0.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 3/31/2009 |
| MULTIPLE RECIPIENTS | $0.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 4/30/2009 |
| MULTIPLE RECIPIENTS | $0.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 6/30/2009 |
| MULTIPLE RECIPIENTS | $0.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 7/31/2009 |
| MULTIPLE RECIPIENTS | $0.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 7/31/2009 |
| MULTIPLE RECIPIENTS | $0.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 8/31/2009 |
| MULTIPLE RECIPIENTS | $0.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 8/31/2009 |
| MULTIPLE RECIPIENTS | $0.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 8/31/2009 |
| MULTIPLE RECIPIENTS | $0.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 5/31/2009 |
| MULTIPLE RECIPIENTS | $0.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 5/31/2009 |
| MULTIPLE RECIPIENTS | $0.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 9/30/2009 |
| MULTIPLE RECIPIENTS | $0.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 9/30/2009 |
| MULTIPLE RECIPIENTS | $0.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 4/30/2009 |
| MULTIPLE RECIPIENTS | $0.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 6/30/2009 |
| MULTIPLE RECIPIENTS | $0.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 5/31/2009 |
| MULTIPLE RECIPIENTS | $0.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 6/30/2009 |
| MULTIPLE RECIPIENTS | $542,896.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 3/31/2009 |
| MULTIPLE RECIPIENTS | $442,162.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 6/30/2009 |
| MULTIPLE RECIPIENTS | $90,066.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 6/30/2009 |
| MULTIPLE RECIPIENTS | $90,066.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 4/30/2009 |
| MULTIPLE RECIPIENTS | $542,896.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 3/31/2009 |
| MULTIPLE RECIPIENTS | $442,162.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 4/30/2009 |
| MULTIPLE RECIPIENTS | $298,414.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 7/31/2009 |
| MULTIPLE RECIPIENTS | $251,471.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 7/31/2009 |
| MULTIPLE RECIPIENTS | $139,795.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 5/31/2009 |
| MULTIPLE RECIPIENTS | $10,240.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 5/31/2009 |
| MULTIPLE RECIPIENTS | $171,859.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 5/31/2009 |
| MULTIPLE RECIPIENTS | $97,920.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 9/30/2009 |
| MULTIPLE RECIPIENTS | $1,051,269.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 9/30/2009 |
| MULTIPLE RECIPIENTS | $132,600.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 9/30/2009 |
| MULTIPLE RECIPIENTS | $7,462.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 6/30/2009 |
| MULTIPLE RECIPIENTS | $210,044.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 8/31/2009 |
| MULTIPLE RECIPIENTS | $222,870.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 8/31/2009 |
| MULTIPLE RECIPIENTS | $198,900.00 | Loan | Single Family Housing Guaranteed Loans - ARRA | Rural Housing Service (07) | 8/31/2009 |
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