Dollars for Profs

Dig Into University Researchers' Outside Income and Conflicts of Interest

Published Dec. 6, 2019

This database was last updated in December 2019 and should only be used as a historical snapshot. There may be new or amended records not reflected here.

Financial doc
Filing Type

Conflict of Interest

Institutions must file significant disclosures to the National Institutes of Health if they determine financial relationships could affect the design, conduct or reporting of the NIH-funded research. The NIH provided us with their entire financial conflict of interest database, with filings from 2012 through 2019.

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Claudio Soto

Case Western Reserve University, Department: Physiology

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Disclosed Conflict of Interest with

Amprion, Inc.

Disclosed Value
Listed Reason
Payment for services (e.g., consulting fees, honoraria, paid authorship)

NA

Listed Research Project
Mechanisms of Transmissibility in Prion Diseases

Transmissible spongiform encephalopathies, or prion diseases, are neurodegenerative disorders that can be transmitted from animals to humans. Understanding the pathogenic process in these disorders and the mechanisms by which they are transmitted within and between species is of fundamental importance for protecting the human population as well for the development of therapeutic strategies. Project 1: Molecular and Structural Basis of Prion Protein Conversion to the Infectious Form Project Leader: Witold Surewicz DESCRIPTION (as provided by applicant): The main focus of Research Project 1 is to elucidate the structural basis of prion protein conversion and the structure of the infectious PrPSc conformer. This Project also seeks to identify specific structural differences in PrPSc that underlie phenotypic variability of human prion diseases. This contributes to the over-arching objective of the Program Project to advance the understanding of the pathogenic process in prion diseases, with a special focus on the mechanisms of disease transmission. A critical gap in TSE research is limited understanding of the structure of PrPSc. This knowledge is fundamental to understanding the mechanism of prion replication. Here we address this issue by a number of complementary approaches, ranging from studies with apparently infectious amyloid fibrils formed by fragment(s) of PrP to structural characterization of highly infectious prions generated from the recombinant full-length PrP and determination of lower-resolution strain-specific structural constraints for brain-derived PrPSc. We anticipate that at the very least, these studies will allow us to (i) identify and characterize the critical seedin element in prion protein conversion to the infectious form, both with regard to its sequence as well as high-resolution structure; (ii) conclusively establish the overall folding motif within the?-core of infectious PrPres aggregates (thereby resolving the major controversy in the field) and determine the identity of individual ?- strands and turns between them; (iii) determine which specific structural features are critical determinants of prion infectivity and use this informatio to advance the development of novel therapeutic strategy based on the concept of self-propagating 'antiprions'.

Filed on November 16, 2017.

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Name Institution Type Company Disclosed Value
Claudio Soto University of Texas Hlth Sci Ctr Houston Conflict of Interest Amprion, Inc. $20,000 - $39,999
Claudio Soto University of Texas Hlth Sci Ctr Houston Conflict of Interest Amprion, Inc. Value cannot be readily determined
Claudio Soto University of Texas Hlth Sci Ctr Houston Conflict of Interest Amprion, Inc. $0 - $4,999
Claudio Soto University of Texas Hlth Sci Ctr Houston Conflict of Interest Amprion, Inc. $20,000 - $39,999
Claudio Soto University of Texas Hlth Sci Ctr Houston Conflict of Interest Amprion, Inc. $0 - $4,999
Claudio Soto University of Texas Hlth Sci Ctr Houston Conflict of Interest Amprion, Inc. $20,000 - $39,999
Claudio Soto University of Texas Hlth Sci Ctr Houston Conflict of Interest Amprion, Inc. Value cannot be readily determined
Claudio Soto University of Texas Hlth Sci Ctr Houston Conflict of Interest Amprion, Inc. $0 - $4,999
Claudio Soto University of Texas Hlth Sci Ctr Houston Conflict of Interest Amprion, Inc. Value cannot be readily determined
Claudio Soto University of Texas Hlth Sci Ctr Houston Conflict of Interest Amprion, Inc. Value cannot be readily determined
If you see an error in the database or a reason we should not disclose a record, please contact us at [email protected] and we'll evaluate it on a case-by-case basis.
Sources: National Institutes of Health, public records requests filed at multiple public state universities

Notes: When a more specific filing date is not available for an individual financial disclosure or conflict of interest form, we use the year the form was filed. If the year was not disclosed, we report the range of years covered by our public records requests. In a few cases, a start date was provided instead of a filing date. In those cases, we use the start date instead.

Fewer than 10% of records from the University of Florida and fewer than 1% of records from the University of Texas system were removed because they did not contain enough information.

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