Dollars for Profs
Dig Into University Researchers' Outside Income and Conflicts of Interest
Published Dec. 6, 2019
This database was last updated in December 2019 and should only be used as a historical snapshot. There may be new or amended records not reflected here.
Conflict of Interest
Institutions must file significant disclosures to the National Institutes of Health if they determine financial relationships could affect the design, conduct or reporting of the NIH-funded research. The NIH provided us with their entire financial conflict of interest database, with filings from 2012 through 2019.
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Andrea Califano
Columbia University Health Sciences, Department: Biochemistry
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Darwin Health
Payment for services (e.g., consulting fees, honoraria, paid authorship)
Dr. Califano's anticipated equity interest in Darwin Health was originally reported as a managed FCOI in connection with this grant in FCOI Report 12872. As noted therein, Dr. Califano is co-founder of a startup company called Darwin Health. Columbia has determined that the company’s aims (commercialization of efforts for systematic identification of aberrantly activated gene products within critical tumor checkpoints that drive cancer initiation, progression, and drug resistance) are related to research described in this award; that the outcome of this research could affect the company or Dr. Califano’s significant financial interest in the company; and that the design, conduct, and/or reporting of this research could be affected by this financial interest.
Columbia now is reporting additional new financial interests for Dr. Califano in Darwin, which have been reviewed and incorporated into the existing management plan. Columbia had originally submitted a new FCOI Report on 5/21/18 (#14131) reporting these new financial interests. For administrative purposes (and after discussion with Kathy Hancock, OPERA Grants Compliance on 5/21/18), the following steps are being taken: (1) FCOI Report 14131 has been rescinded, (2) we are reporting the FCOI described in FCOI Report 12872 as no longer existing, and (3) we are consolidating the reporting of all of Dr. Califano’s Darwin financial interests and the FCOI management for this award into this new FCOI report.
Systematic Identification and Pharmacological Targeting of Tumor Dependencies for Precision Cancer Medicine
PROJECT NARRATIVE Genetically-based targeted therapy and immunoncology hold great promise but patients eventually relapse with drug resistant tumors suggesting that one may need to revisit the concept of therapeutic targets as single proteins. To accomplish this goal, we will leverage a highly successful framework developed by us for the identification, validation, and pharmacological targeting of tumor dependencies implemented by master regulator (MR) proteins in tumor checkpoint modules. This would represent the first mechanistic approach for precision cancer medicine, where therapeutic targets, associated small molecule inhibitors, and population stratification biomarkers are derived from precise, mechanistic understanding of tumor state regulation and of its drug-induced modulation.
Filed on May 21, 2018.
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Andrea Califano filed other conflict of interest disclosures with the NIH:
| Name | Institution | Type | Company | Disclosed Value |
|---|---|---|---|---|
| Andrea Califano | Columbia University Health Sciences | Conflict of Interest | Darwin Health | $60,000 - $79,999 |
| Andrea Califano | Columbia University Health Sciences | Conflict of Interest | Darwin Health | $60,000 - $79,999 |
| Andrea Califano | Columbia University Health Sciences | Conflict of Interest | Darwin Health | $60,000 - $79,999 |
| Andrea Califano | Columbia University Health Sciences | Conflict of Interest | Darwin Health | $0 - $4,999 |
| Andrea Califano | Columbia University Health Sciences | Conflict of Interest | Darwin Health | $0 - $4,999 |
| Andrea Califano | Columbia University Health Sciences | Conflict of Interest | Darwin Health | $0 - $4,999 |
| Andrea Califano | Columbia University Health Sciences | Conflict of Interest | Darwin Health | $0 - $4,999 |
| Andrea Califano | Columbia University Health Sciences | Conflict of Interest | Darwin Health | Value cannot be readily determined |
| Andrea Califano | Columbia University Health Sciences | Conflict of Interest | Darwin Health | Value cannot be readily determined |
| Andrea Califano | Columbia University Health Sciences | Conflict of Interest | Darwin Health | Value cannot be readily determined |
| Andrea Califano | Columbia University Health Sciences | Conflict of Interest | Darwin Health | Value cannot be readily determined |
Notes: When a more specific filing date is not available for an individual financial disclosure or conflict of interest form, we use the year the form was filed. If the year was not disclosed, we report the range of years covered by our public records requests. In a few cases, a start date was provided instead of a filing date. In those cases, we use the start date instead.
Fewer than 10% of records from the University of Florida and fewer than 1% of records from the University of Texas system were removed because they did not contain enough information.
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