Dollars for Profs
Dig Into University Researchers' Outside Income and Conflicts of Interest
Published Dec. 6, 2019
This database was last updated in December 2019 and should only be used as a historical snapshot. There may be new or amended records not reflected here.
Conflict of Interest
Institutions must file significant disclosures to the National Institutes of Health if they determine financial relationships could affect the design, conduct or reporting of the NIH-funded research. The NIH provided us with their entire financial conflict of interest database, with filings from 2012 through 2019.
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David Sinclair
Harvard Medical School, Department: Genetics
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Jumpstart Fertility (a subsidiary of Life Biosciences)
Equity Interest - Non-publicly traded entity ( e.g., stock, stock option, or other ownership interest)
Jumpstart Fertility is interested in NMN to improve IVF. The research project proposes to study radiation protection by NMN in a model of oral mucositis. The company may be interested in the outcomes of the research.
Nicotinamide Mononucleotide (NMN) as a Novel Therapeutic in the Treatment of Oral Mucositis
NARRATIVE Oral mucositis is one of the most frequent side effects associated with cancer therapies that involves breakdown of the mucosa in the mouth and gut, which, in severe cases, limits the treatment and worsens prognosis for the patient. Chemo-radiation treatment leads to rapid hyperactivation of a group of DNA-repairing enzymes known as poly-ADP-ribose polymerases (PARPs) that deplete nicotinamide adenine dinucleotide (NAD+) and reduce the activity of SIRT1, an anti-inflammatory signaling protein. We will test the hypothesis that the maintenance of NAD+ levels by treatment with a precursor to NAD+, nicotinamide mononucleotide (NMN), will maintain SIRT1 activity and reduce the severity and duration of radiation-induced mucositis, which will further lead to a better understanding of mucositis and a rapid clinical path to treating this common, debilitating condition.
Filed on September 12, 2018.
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David Sinclair filed other conflict of interest disclosures with the NIH:
| Name | Institution | Type | Company | Disclosed Value |
|---|---|---|---|---|
| David Sinclair | Harvard Medical School | Conflict of Interest | Cohbar, Inc. | >$600,000 |
| David Sinclair | Harvard Medical School | Conflict of Interest | OvaScience | >$600,000 |
| David Sinclair | Harvard Medical School | Conflict of Interest | Life Biosciences | $250,000 - $299,999 |
| David Sinclair | Harvard Medical School | Conflict of Interest | Ovscience | $40,000 - $59,999 |
| David Sinclair | Harvard Medical School | Conflict of Interest | Ovscience | $40,000 - $59,999 |
| David Sinclair | Harvard Medical School | Conflict of Interest | GlaxoSmithKline | $40,000 - $59,999 |
| David Sinclair | Harvard Medical School | Conflict of Interest | Senolytic Therapeutics | $40,000 - $59,999 |
| David Sinclair | Harvard Medical School | Conflict of Interest | OvaScience | $10,000 - $19,999 |
| David Sinclair | Harvard Medical School | Conflict of Interest | GlaxoSmithKline | $5,000 - $9,999 |
| David Sinclair | Harvard Medical School | Conflict of Interest | OvaScience | $5,000 - $9,999 |
| David Sinclair | Harvard Medical School | Conflict of Interest | Life Biosciences (parent company) and Jumpstart Fertility (wholly owned subsidiary operated by Life) | $0 - $4,999 |
| David Sinclair | Harvard Medical School | Conflict of Interest | Jupiter Orphan Therapeutics | Value cannot be readily determined |
| David Sinclair | Harvard Medical School | Conflict of Interest | Liberty Biosecurity (wholly owned and operated subsidiary of EdenRoc Sciences) and EdenRoc Sciences | Value cannot be readily determined |
| David Sinclair | Harvard Medical School | Conflict of Interest | Metrobiotech East, LLC | Value cannot be readily determined |
| David Sinclair | Harvard Medical School | Conflict of Interest | EdenRoc Science | Value cannot be readily determined |
| David Sinclair | Harvard Medical School | Conflict of Interest | Life Biosciences (parent company) and Jumpstart Fertility (wholly owned subsidiary operated by Life) | Value cannot be readily determined |
| David Sinclair | Harvard Medical School | Conflict of Interest | Life Biosciences | Value cannot be readily determined |
| David Sinclair | Harvard Medical School | Conflict of Interest | Spotlight Biosciences Inc. | Value cannot be readily determined |
| David Sinclair | Harvard Medical School | Conflict of Interest | Liberty Biosecurity (wholly owned and operated subsidiary of EdenRoc Sciences) and EdenRoc Sciences | Value cannot be readily determined |
| David Sinclair | Harvard Medical School | Conflict of Interest | Senolytic Therapeutics | Value cannot be readily determined |
| David Sinclair | Harvard Medical School | Conflict of Interest | MetroBiotech Midatlantic, LLC | Value cannot be readily determined |
| David Sinclair | Harvard Medical School | Conflict of Interest | Life Biosciences (parent company) and Jupiter Orphan (wholly owned subsidiary operated by Life) | Value cannot be readily determined |
| David Sinclair | Harvard Medical School | Conflict of Interest | EdenRoc Sciences (parent company of Metro International Biotech and Liberty Biosecurity) | Value cannot be readily determined |
| David Sinclair | Harvard Medical School | Conflict of Interest | Iduna Therapeutics | Value cannot be readily determined |
Notes: When a more specific filing date is not available for an individual financial disclosure or conflict of interest form, we use the year the form was filed. If the year was not disclosed, we report the range of years covered by our public records requests. In a few cases, a start date was provided instead of a filing date. In those cases, we use the start date instead.
Fewer than 10% of records from the University of Florida and fewer than 1% of records from the University of Texas system were removed because they did not contain enough information.
ProPublica obtained additional financial disclosures and conflict of interest forms that we have not yet digitized and added to the database. You can download those disclosures in the ProPublica Data Store.