Dollars for Profs
Dig Into University Researchers' Outside Income and Conflicts of Interest
Published Dec. 6, 2019
This database was last updated in December 2019 and should only be used as a historical snapshot. There may be new or amended records not reflected here.
Conflict of Interest
Institutions must file significant disclosures to the National Institutes of Health if they determine financial relationships could affect the design, conduct or reporting of the NIH-funded research. The NIH provided us with their entire financial conflict of interest database, with filings from 2012 through 2019.
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Richard Morimoto
Northwestern University, Department: Biochemistry
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Proteostasis Therapeutics, Inc.
Payment for services (e.g., consulting fees, honoraria, paid authorship)
This proposal aims to examine the basis of intertissue signaling in the regulation of organismal proteostasis, and specifically investigating how intertissue signaling affects the organismal response to proteotoxicity during aging, using a model organism, C. elegans. This proposal also looks to investigate how proteotoxic proteins Abeta, tau or polyQ (misfolding and/or aggregation of which are all associated with diseases) affect peripheral proteostasis, and whether the organismal proteostasis network (PN) can be restored through genetic and small molecule approaches. Proteostasis Therapeutics has the goal of developing novel therapeutics designed to characterize and pharmacologically control the proteostasis network in cells, and which focuses on protein aggregation diseases. While the work included in this proposal examines basic mechanisms relating to proteostasis, the similarity of these studies and the broad goals of Proteostasis Therapeutics suggest the potential for a perceived conflict of interest that should be managed.
Regulation of Peripheral Proteostasis
PROJECT NARRATIVE Among the most daunting diseases are those known as protein conformational diseases that cause neurodegeneration including Alzheimer's disease, Parkinson's disease, ALS and Huntington's disease. Each of these diseases and hundreds of others are due to protein aggregation and resulting tissue failure. This proposal is to address how different tissues communicate and coordinate the cellular response to aggregation and proteotoxicity.
Filed on September 28, 2017.
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Richard Morimoto filed other conflict of interest disclosures with the NIH:
| Name | Institution | Type | Company | Disclosed Value |
|---|---|---|---|---|
| Richard Morimoto | Northwestern University | Conflict of Interest | Proteostasis Therapeutics, Inc. | >$600,000 |
| Richard Morimoto | Northwestern University | Conflict of Interest | Proteostasis Therapeutics | $40,000 - $59,999 |
| Richard Morimoto | Northwestern University | Conflict of Interest | Proteostasis Therapeutics, Inc. | $20,000 - $39,999 |
| Richard Morimoto | Northwestern University | Conflict of Interest | Proteostasis Therapeutics | Value cannot be readily determined |
| Richard Morimoto | Northwestern University | Conflict of Interest | Proteostasis Therapeutics, Inc. | Value cannot be readily determined |
Notes: When a more specific filing date is not available for an individual financial disclosure or conflict of interest form, we use the year the form was filed. If the year was not disclosed, we report the range of years covered by our public records requests. In a few cases, a start date was provided instead of a filing date. In those cases, we use the start date instead.
Fewer than 10% of records from the University of Florida and fewer than 1% of records from the University of Texas system were removed because they did not contain enough information.
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