Recovery Tracker

How Much Stimulus Funding is Going to Your County?

Listing all stimulus spending by amount, in descending order. Return to National Institutes of Health page

Amount refers to both the amount of stimulus funding going toward the project and the face value of the loan.

Recipient Amount Type Description Federal Dept./Agency Date
UNIVERSITY OF KENTUCKY $998,571 Grant Trans-NIH Recovery Act Research Support: Broad goals and specific aims: Kentucky ranks among the worst in the nation for its burdens of diabetes (41st ) and obesity (46th), which are major contributors to the fact that Kentucky ranks 44th for its all-cause mortality rate. The proposed Kentucky D Health and Human Services, Department of / National Institutes of Health 8/09/2010
UNIVERSITY OF CALIFORNIA, LOS ANGELES $297,000 Grant Trans-NIH Recovery Act Research Support: This project is a Recovery Act Administrative Supplement for Comparative Effectiveness Research (CER) Workforce Development to the University of California-Los Angeles (UCLA) K30 Graduate Training Program in Translational and Clinical Investigation. The U Health and Human Services, Department of / National Institutes of Health 8/26/2010
RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE $80,835 Grant Trans-NIH Recovery Act Research Support: Fusion between two eukaryotic cells is a fundamentally interesting and biologically important process. We have only a rudimentary understanding of how cell fusion occurs. This grant proposal focuses on characterizing the process of anastomosis (vegetative Health and Human Services, Department of / National Institutes of Health 7/14/2010
JOHNS HOPKINS UNIVERSITY, THE $66,420 Grant Trans-NIH Recovery Act Research Support: Our long-term objective is to understand the host factors that regulate the systemic inflammation andpathogenesis of sepsis, which affects 750,000 persons every year in United States alone and causes high mortality worldwide. We recently discovered a nove Health and Human Services, Department of / National Institutes of Health 8/27/2010
JOHNS HOPKINS UNIVERSITY, THE $505,233 Grant Trans-NIH Recovery Act Research Support: The major goal of this one-year project is to provide a firm foundation for the mechanistic analysis of pathology development in Wilson?s disease (WD). WD is a severe human disorder of copper homeostasis. The gene mutated in WD encodes a copper-transporti Health and Human Services, Department of / National Institutes of Health 8/23/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $25,000 Grant Trans-NIH Recovery Act Research Support: The scope of the parent grant (1R03HD059717-01) is the Screening of Human Milk Oligosaccharides that Protect Infants from HIV Infections. Breast-feeding is the predominant transmission route for HIV-1 infection in children. However, the vast majority of b Health and Human Services, Department of / National Institutes of Health 9/01/2010
COMPACT MEMBRANE SYSTEMS, INC. $196,852 Grant Trans-NIH Recovery Act Research Support: The objective of this program is to build a platform technology based on developing membrane-crystallization technology to produce crystals of active pharmaceutical ingredients in which the crystal size and crystal form polymorph or pseudo-polymorph are c Health and Human Services, Department of / National Institutes of Health 6/01/2010
UNIVERSITY OF ALABAMA AT BIRMINGHAM $138,285 Grant Trans-NIH Recovery Act Research Support: This administrative supplement to our UAB Infectious Diseases Training grant will expand and enhance our ability to train investigators in Comparative Effectiveness Research (CER). The UAB ID division has been a leader in CER in HIV, STD, and Opportunisti Health and Human Services, Department of / National Institutes of Health 6/21/2010
BIOSENSE TECHNOLOGIES, INC. $1,998,687 Grant Trans-NIH Recovery Act Research Support: Platelet transfusion is the leading cause of transfusion related bacterial sepsis. Despite the mandated testing of platelet concentrate (PC) for contaminant bacteria, limitations in currently used testing methods continue to result in a significant number Health and Human Services, Department of / National Institutes of Health 6/10/2010
ASTRAEA THERAPEUTICS LLC $241,423 Grant Trans-NIH Recovery Act Research Support: Parkinson?s disease (PD) is one of the more common and serious neurodegenerative diseases and occurs in 2% of the population over 60. Its main therapy, L-Dopa, is associated with severe and worsening symptoms that inevitably occur after continued therapy, Health and Human Services, Department of / National Institutes of Health 7/01/2010
REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE $76,620 Grant Trans-NIH Recovery Act Research Support: Bisphenol A is one of the highest production volume chemicals in the world and has recently been the focus of much public health concern. Animal studies point towards metabolism-disrupting effects of BPA, but little research has been conducted in humans. Health and Human Services, Department of / National Institutes of Health 5/28/2010
COLORADO STATE UNIVERSITY $30,639 Grant Trans-NIH Recovery Act Research Support: 670,000 new cases of leprosy were detected during the year 2002. What are the factors that contributed to this high incidence even though effective multidrug therapy implemented by the World Health Organization has been used to treat leprosy patients over Health and Human Services, Department of / National Institutes of Health 5/24/2010
EMORY UNIVERSITY $499,534 Grant Trans-NIH Recovery Act Research Support: This is extra funding for the Emory HIV/AIDS Clinical Trials Unit supplement designated for the HPTN protocols 061 and 064. The award will provide support for the analysis and closeout functions needed for these two protocols. Health and Human Services, Department of / National Institutes of Health 5/24/2010
BROWN UNIVERSITY IN PROVIDENCE IN STATE OF RI AND PROVIDENCE PLANTATIONS $96,391 Grant Trans-NIH Recovery Act Research Support: The supplement funds will be used to increase the sample size in order to allow for a more efficient test of the hypothesized effects of the community health worker (CHW) behavioral intervention on diabetes management. Funds will be used to deliver the in Health and Human Services, Department of / National Institutes of Health 6/15/2010
WAYNE STATE UNIVERSITY (INC) $1,044,749 Grant Trans-NIH Recovery Act Research Support: Aims of the proposal: 1) Contribute to the development and competency of pre-service STEM teachers through integration of Environmental Health-based Biotechnology lessons into an existing methods course. 2) Intergrate Environmental health science researc Health and Human Services, Department of / National Institutes of Health 9/30/2009
NEW JERSEY INSTITUTE OF TECHNOLOGY $64,369 Grant Trans-NIH Recovery Act Research Support: The following supplement for summer 2010 will accelerate our current research project. We will be employing seven undergraduate students for research. They will develop a SW prototype for automatic drawing of the partial area diagrams, which play a major Health and Human Services, Department of / National Institutes of Health 6/28/2010
MAVEN TECHNOLOGIES, LLC $1,965,039 Grant Trans-NIH Recovery Act Research Support: Development of an Optical Instrument For Label-Free Assays. This project will bring to market an optical instrument capable of diagnosing complex diseases in minutes using minimally invasive strategies requiring just a drop of blood, saliva, or other bodi Health and Human Services, Department of / National Institutes of Health 9/27/2010
CASE WESTERN RESERVE UNIVERSITY $2,435,464 Contract : The Systolic Blood Pressure Intervention Trial (SPRINT). SRINT is a 2-arm, multicenter, randomized clinical trial designed to test whether a treatment program aimed at reducing systolic blood pressure (SBP) to a lower goal than currently recommended will Health and Human Services, Department of / National Institutes of Health 9/23/2010
TRUSTEES OF INDIANA UNIVERSITY $139,024 Grant Trans-NIH Recovery Act Research Support: The PI has long studied behavioral development in rodents and contributed to basic knowledge of fetal sensory function, perinatal behavior, contact behavior (huddling), suckling, energy homeostasis, and parent-offspring interactions. This K18 project woul Health and Human Services, Department of / National Institutes of Health 9/22/2010
MAYO CLINIC $222,948 Contract : The Mayo Foundation has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of hepatocellular cases. These cases are all primary and untreated. The colle Health and Human Services, Department of / National Institutes of Health 6/25/2010
LEICA MICROSYSTEMS INC $272,634 Contract : TCS SP5 CONFOCAL SYSTEM PURCHASE Health and Human Services, Department of / National Institutes of Health 9/14/2010
UNIVERSITY OF MASSACHUSETTS $411,250 Grant Trans-NIH Recovery Act Research Support: Shigellae are a group of Gram-negative enteric bacilli that cause acute bacillary dysentery in humans. The signature feature of this disease is exhibited by an intense inflammatory reaction manifested clinically as passage of bloody stools. Humans and so Health and Human Services, Department of / National Institutes of Health 9/30/2010
UNIVERSITY OF MISSOURI SYSTEM $1,000,000 Grant Trans-NIH Recovery Act Research Support: African Americans continue to experience striking health disparities, including shorter life expectancy and higher rates of cancer, heart disease, stroke, diabetes, substance abuse, and infant mortality and low birth weights (NCMHD). African Americans hav Health and Human Services, Department of / National Institutes of Health 7/06/2010
THE VANDERBILT UNIVERSITY $145,638 Grant Trans-NIH Recovery Act Research Support: This supplement will increase both the rate and quality of our research by 1 supporting a skilled research position that would otherwise be lost to the program, and 2 preserving genetically unique mouse lines for type 1 diabetes research. This supplement Health and Human Services, Department of / National Institutes of Health 8/16/2010
QIAGEN INC. $41,687 Contract : QTY 48 QIAamp Viral RNA Mini Kit (250) and QTY 48 QIAquick Gel Extraction Kit (250) Health and Human Services, Department of / National Institutes of Health 9/28/2010
MAGEE-WOMENS HEALTH CORPORATION $11,139 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This Program Project addresses among the most important questions in stem cell medicine and biology through responsible studies on the potentials of pluripotent stem cells from humans (hESC) and nonhuman primates (nhpE Health and Human Services, Department of / National Institutes of Health 5/10/2010
UNIVERSITY OF ALABAMA AT BIRMINGHAM $614,565 Grant Trans-NIH Recovery Act Research Support: The ARRA grant provides an opportunity to execute a core consolidation that will have enormous benefits for our user-base on a day-to-day basis. This funding allows for purchased of a new peice of major equipment, major upgrades to an exisiting peice, ove Health and Human Services, Department of / National Institutes of Health 7/26/2010
RIDGE DIAGNOSTICS, INC. $200,000 Grant Trans-NIH Recovery Act Research Support: USING A BIOMARKER PANEL FOR DETECTING ADOLESCENT DEPRESSION: Approximately 6% of all U.S. teenagers suffer from clinical depression which is known to result in continued risk for recurrences with persistence of depressive episodes and psychosocial morbidi Health and Human Services, Department of / National Institutes of Health 7/27/2010
WAKE FOREST UNIVERSITY $34,445 Grant Trans-NIH Recovery Act Research Support: Influenza epidemic control is an important public health priority, and the application of isolation, vaccination, and drug treatment measures to control influenza is based on an incomplete understanding of influenza virus epidemiology. Several limited stu Health and Human Services, Department of / National Institutes of Health 9/29/2010
CHILDREN'S HOSPITAL CORPORATION, THE $240,566 Grant Trans-NIH Recovery Act Research Support: Newborns are at increased risk of infection yet the mechanisms underlying their susceptibility are incompletely defined. Toll-like receptors (TLRs) play crucial roles in the recognition of microbial components including bacterial lipopeptides (BLPs), expr Health and Human Services, Department of / National Institutes of Health 7/19/2010
MAYO CLINIC $99,835 Grant Trans-NIH Recovery Act Research Support: The primary goal of our UOl application titled Optimization of Small-Molecule Inhibitors of Shiga and Ricin Toxins (5UOlAI082120) is to develop second-generation small-molecule inhibitors of Shiga-like toxin 2 (Sro) and ricin. Despite the challenge that s Health and Human Services, Department of / National Institutes of Health 7/12/2010
Q TRACK CORPORATION $89,133 Grant Trans-NIH Recovery Act Research Support: Radiation exposure of nuclear workers is not only a serious health and safety issue, but also imposes substantial costs on nuclear utilities. Precise knowledge of the radiation environment within a nuclear facility is essential to minimizing personnel exp Health and Human Services, Department of / National Institutes of Health 5/28/2010
MOLECULAR DEVICES, INC. $167,000 Contract : IsoCyte Single Laser Instrument Health and Human Services, Department of / National Institutes of Health 11/10/2009
VYBION, INC. $200,000 Loan Arthritis, Musculoskeletal and Skin Diseases Research: Rapid isolation of high-affinity human antibodies from large synthetic libraries Health and Human Services, Department of / National Institutes of Health 1/29/2010
UNIVERSITY OF ALABAMA AT BIRMINGHAM $99,870 Grant Trans-NIH Recovery Act Research Support: B lymphocytes are required for host defense against infectious pathogens but abnormal activation of B cells can lead to autoimmunity. Thus, B cells are important in a wide range of physiologic and pathophysiologic processes. Mature B cells in the spleen e Health and Human Services, Department of / National Institutes of Health 6/29/2010
GLOBAL VACCINES INC $518,489 Grant Trans-NIH Recovery Act Research Support: A Novel Sysstemic and Mucosal Adjuvant for Biodefense. Health and Human Services, Department of / National Institutes of Health 6/28/2010
UNIVERSITY OF ARKANSAS SYSTEM $93,358 Grant Trans-NIH Recovery Act Research Support: We are requesting funds to purchase a new gas chromatograph mass spectrometer. This project involves tracing a variety of metabolic pathways using stable isotope tracers. The study will be performed in pigs with multiple catheters, placed so that regional Health and Human Services, Department of / National Institutes of Health 6/17/2010
SO-LOW ENVIRONMENTAL EQUIPMENT CO (INC) $2,894 Contract : LABORATORY EQUIPMENT AND SUPPLIES Health and Human Services, Department of / National Institutes of Health 4/05/2010
CLAFLIN UNIVERSITY $214,897 Grant Trans-NIH Recovery Act Research Support: Research enhancement (R15) award to detrmine protein fold specific rules in enzymatic adaptation to temperature constraints. To understand how structure adapts to selctive pressures of high and low temperature and understand what amino acid changes are ne Health and Human Services, Department of / National Institutes of Health 9/09/2009
RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE $396,250 Grant Trans-NIH Recovery Act Research Support: Moraxella catarrhalis is an important human respiratory tract pathogen. Approximately 25 million episodes of otitis media occur in children in the US annually; 15 to 20% of these are caused by M. catarrhalis, based on results of cultures of middle ear flu Health and Human Services, Department of / National Institutes of Health 6/28/2010
UNIVERSITY OF ARKANSAS SYSTEM $118,054 Grant Trans-NIH Recovery Act Research Support: The objective of this project is to use novel quantitative proteomic method to systematically identify Bax interacting proteins that may play critical roles in keeping Bax in check in the cytosol of healthy cells. The identifications of novel Bax interact Health and Human Services, Department of / National Institutes of Health 5/14/2010
BREONICS, INC. $2,926,003 Grant Trans-NIH Recovery Act Research Support: This award includes funding under the American Recovery and Reinvestment Act of 2009 (ARRA) and is issued in response to Notice RFA-OD-09-008, Recovery Act Limited Competition: Biomedical Research, Development, and Growth to Spur the Acceleration of New T Health and Human Services, Department of / National Institutes of Health 6/23/2010
BANYAN BIOMARKERS INC. $45,917 Grant Trans-NIH Recovery Act Research Support: TO ACELERATE THE PRODUCTION OF DIAGNOSTIC PANEL FOR LIVER INJURY AND VALIDATE THE UTILITY OF THE PANEL WITH AN EMPHASIS ON DRUG-INDUCED HEPATOTOXICITY. Health and Human Services, Department of / National Institutes of Health 3/10/2010
HAMILTON COMPANY $165,140 Contract : Recovery/AARA Equipment Order James L. Kish, P.S., 301-402-2282 Quote No. q_NIH_Wang_STARlet 8_98 Health and Human Services, Department of / National Institutes of Health 1/08/2010
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE $277,711 Grant Trans-NIH Recovery Act Research Support: The long-term goal of our research program is to understand the functional role of taste receptors (TRs) in pancreatic ?-cells. We have found that a novel class of nutrient-binding G-protein coupled receptors, TRs, is expressed in pancreatic ?-cells. We d Health and Human Services, Department of / National Institutes of Health 6/28/2010
UNIVERSITY OF MONTANA SYSTEM $54,450 Grant Trans-NIH Recovery Act Research Support: This supplemental request is to provide additioal funding for RC2ES018742-01 to support our collaborative effort in conducting transciptome and proteome analysis of human mucosal epithelial cells and macrophages in an effort to link those responses to in Health and Human Services, Department of / National Institutes of Health 6/11/2010
UNIVERSITY OF ALABAMA AT BIRMINGHAM $42,675 Grant Trans-NIH Recovery Act Research Support: The B1a (CD5+) B-cells are the primary producers of natural antibodies that are self-reactive and polyreactive but usually non-pathogenic. However, in some circumstances, B1a B-cells contribute substantially to the immunopathogenesis of chronic systemic a Health and Human Services, Department of / National Institutes of Health 6/29/2010
ILLINOIS COLLEGE OF OPTOMETRY $267,238 Grant Trans-NIH Recovery Act Research Support: Accommodation is a main function of the lens. During dynamic focusing, the shape of the lens is changed. The accommodative ability of the lens decreases throughout life, such that it becomes a noticeable problem by around the age of 40. It is proposed tha Health and Human Services, Department of / National Institutes of Health 5/26/2010
UNIVERSITY OF LA VERNE $57,346 Grant Trans-NIH Recovery Act Research Support: This award will fund one Post-Baccalaureate Research Assistant for Prenatal Developmental Immunotoxicity of Diethylstilbestrol and Methoxychlor research. Health and Human Services, Department of / National Institutes of Health 6/24/2010
UNIVERSITY OF CALIFORNIA, LOS ANGELES $28,731 Grant Trans-NIH Recovery Act Research Support: The overall purpose of this supplement is to provide research opportunities to students interested in hazmat worker health and safety issues. Specifically, the supplement will be used to support four undergraduate students at the UCLA Labor Occupational S Health and Human Services, Department of / National Institutes of Health 5/28/2010
PACIFIC BIOSCIENCES OF CALIFORNIA, INC. $1,970,752 Grant Trans-NIH Recovery Act Research Support: In this program, we will enable direct sequencing from RNA templates by adapting Pacific BiosciencesG?? high throughput Single-Molecule Real-Time (SMRT) DNA sequencing to an RNA-dependent polymerase so SMRT RNA sequencing can be performed on the same inst Health and Human Services, Department of / National Institutes of Health 6/14/2010
UNIVERSITY OF TOLEDO, THE $1,649,791 Grant Trans-NIH Recovery Act Research Support: This is a proposal to validate the accuracy of a multi-gene Lung Cancer Risk Test (LCRT). An accurate LCRT may be used to design more efficient lung cancer screening and/or chemoprevention studies by enabling enrollment of the highest risk individuals, re Health and Human Services, Department of / National Institutes of Health 9/30/2009
UNIVERSITY OF CALIFORNIA, LOS ANGELES $46,200 Grant Trans-NIH Recovery Act Research Support: Characterizing the role of CREB in leukemogenesis and normal myelopoiesis The overall purpose of this project is to characterize the mechanism by which CREB regulates normal and abnormal myelopoiesis. Expected outcomes: CREB increases short-term engraftme Health and Human Services, Department of / National Institutes of Health 6/10/2010
UNIVERSITY OF ALABAMA AT BIRMINGHAM $366,250 Grant Trans-NIH Recovery Act Research Support: The incidence of Juvenile Diabetes, more commonly known as Type 1 Diabetes (T1D), along with other auto-immune related diseases, such as Asthma, are increasing in western-style societies. Of multiple human infectious diseases thought to be associated with Health and Human Services, Department of / National Institutes of Health 6/07/2010
AR CHILDRENS HOSPITAL RESEARCH INSTITUTE $95,657 Grant Trans-NIH Recovery Act Research Support: This is a supplement to the autism is a behavioral condition defined by deficient social interaction, language and communication, and play. Children with autism can exhibit a number of behaviors including severe tantrums, noncompliance, destructiveness, a Health and Human Services, Department of / National Institutes of Health 6/26/2010
TRUSTEES OF DARTMOUTH COLLEGE $237,000 Grant Trans-NIH Recovery Act Research Support: The overall goal of this program is to elucidate signaling pathways from the insulin receptor at the molecular level. The specific aims are to elucidate the roles of RalGAP2 and other novel Akt substrates in insulin signaling and to carry out phosphoprote Health and Human Services, Department of / National Institutes of Health 6/25/2010
PLX PHARMA INC $798,642 Grant Trans-NIH Recovery Act Research Support: PLx Pharma is a pharmaceutical company developing GI safer formulations of proven nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, aspirin, and naproxen. PLx has created novel NSAID formulations, using a natural gastroprotective agent, Health and Human Services, Department of / National Institutes of Health 4/30/2010
OKLAHOMA MEDICAL RESEARCH FOUNDATION $0 Grant Trans-NIH Recovery Act Research Support: We request funding for a dual-purpose microarray platform, an iScan-? system with Autoloader 2 by Illumina, Inc. This instrument will perform high-density genome wide association and methylation studies, custom single nucleotide polymorphism (SNP) detecti Health and Human Services, Department of / National Institutes of Health 6/10/2010
BAYLOR COLLEGE OF MEDICINE $220,647 Grant Trans-NIH Recovery Act Research Support: During the funding of the current R-01, our team made 4 discoveries related to human and mouse somatostatin receptor subtype five (hSSTR5, mSSTR5) and pancreatic duodenal homeobox-1 (PDX-1) that are highly translatable for patients suffering with islet ne Health and Human Services, Department of / National Institutes of Health 6/17/2010
ALASKA NATIVE TRIBAL HEALTH CONSORTIUM INC $320,000 Grant Trans-NIH Recovery Act Research Support: This supplement has allowed progress of the Alaska Native Stroke Registry behavioral risk survey instrument, per the intended purpose of the grant award. Better understanding behavioral risk factors for stroke will allow the project to develop more effec Health and Human Services, Department of / National Institutes of Health 6/30/2010
PROTIVITI GOVERNMENT SERVICES, INC. $462,600 Contract : Recovery-Professional Information Technology Program and technical Services to the Support of the Federated Identity Management Initiative. Health and Human Services, Department of / National Institutes of Health 3/18/2010
BAYLOR RESEARCH INSTITUTE, THE $4,499,507 Grant Trans-NIH Recovery Act Research Support: Vaccines represent the major success of immunology and have spared countless numbers of people from infections. Despite this success, we understand little about how effective vaccines stimulate protective immune responses. We surmise that understanding th Health and Human Services, Department of / National Institutes of Health 7/12/2010
TRIPLE F FARMS INC $173,291 Contract : ARRA Influenza Project ? Animal Model: Ferrets are required for animal research studies using H1N1 influenza. The deliverables include: 750 female ferrets; ferret serum samples; packaging and shipping of blood samples; filtered shipping crates and air fre Health and Human Services, Department of / National Institutes of Health 6/18/2010
UNIVERSITY OF NEW ORLEANS $90,292 Grant Trans-NIH Recovery Act Research Support: The parent grant to this supplemental award was two interconnected research aied to reconstruct signaling pathways from integrated gene expression data. Through this award, we are accelerating the research progress. Specifically, we will implement the Health and Human Services, Department of / National Institutes of Health 6/01/2010
ASKLEPIOS BIOPHARMACEUTICAL, INC $2,999,988 Grant Trans-NIH Recovery Act Research Support: This RC3 project award is designed to develop a hemophilia B nucleic-acid- (DNA-) based therapy capable of mediating multi-year expression of Factor IX (FIX) at therapeutic levels from a single administration that is anticipated to cost less than 2 years Health and Human Services, Department of / National Institutes of Health 6/01/2010
INVASC THERAPEUTICS, INC. $199,932 Grant Trans-NIH Recovery Act Research Support: Cardiovascular diseases are the number one killer around the world. Myeloperoxidase enzyme (MPO) has been implicated in many cardiovascular diseases but there are no MPO inhibitor drugs available for treatment. The development of novel therapy for MPO e Health and Human Services, Department of / National Institutes of Health 5/17/2010
MIAMI UNIVERSITY $426,000 Grant Trans-NIH Recovery Act Research Support: Drosophila RNP-4F is an ortholog to human p110, which functions with the pre-mRNA processing (PRP) protein class as a recycling factor to carry U4- and U6-snRNPs to the assembling spliceosome. Both inherited and acquired defects in pre-mRNA processing ar Health and Human Services, Department of / National Institutes of Health 6/25/2010
UNIVERSITY OF ALABAMA AT BIRMINGHAM $437,409 Grant Trans-NIH Recovery Act Research Support: Bacillus anthracis, the causative agent of anthrax, is a highly pathogenic bacterium considered to be a serious threat as an agent of bioterrorism. The recent use of this bacterium as a terrorist weapon in the United States exposed the need for a more ef Health and Human Services, Department of / National Institutes of Health 6/07/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $159,617 Grant Trans-NIH Recovery Act Research Support: An administrative supplement funded through the American Recovery and Reinvestment Act of 2009 is requested to support the salary of a full-time research technician and to cover the costs of supplies to further develop novel recombinant CD3 immunotoxins t Health and Human Services, Department of / National Institutes of Health 8/23/2010
CHARLES RIVER LABORATORIES, INC. $1,391,398 Contract : Produce and test 8 lots of influenza challenge virus for the purpose of supporting ongoing influenza projects within the Division of Intramural Research, NIAID. Due to the critical public need for H1N1 therapies, vaccines, and diagnostics, this project ha Health and Human Services, Department of / National Institutes of Health 9/13/2010
FRED HUTCHINSON CANCER RESEARCH CENTER $184,863 Grant Trans-NIH Recovery Act Research Support: Natural Killer (NK) cells and regulatory T cells (Tregs) lie at the interface between innate and adaptive immune control of viral infections. Their activities impact HIV-1 disease progression, but they have not been well-studied in HIV-exposed uninfected Health and Human Services, Department of / National Institutes of Health 6/30/2010
AR CHILDRENS HOSPITAL RESEARCH INSTITUTE $99,315 Grant Trans-NIH Recovery Act Research Support: Optimal Amino Acid Nutrition in Sepsis study which these funds will pay for a piece of equipment as proposed. Equipment has been ordered and received. Health and Human Services, Department of / National Institutes of Health 4/23/2010
UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) $390,000 Grant Trans-NIH Recovery Act Research Support: In this application we will explore the hypothesis that Toll-like receptor 2 (TLR2) is the master regulator controlling both protective and pathologic features of the tubercle granuloma. The hypothesis builds on novel findings made in our laboratory. Prev Health and Human Services, Department of / National Institutes of Health 9/01/2009
TRIPLE F FARMS INC $33,210 Contract : ARRA Influenza Project ? Animal Model: Ferrets are required for animal research studies using H1N1 influenza. The deliverables include: 132 female ferrets; ferret serum samples; packaging and shipping of blood samples; filtered shipping crates and air fre Health and Human Services, Department of / National Institutes of Health 3/08/2010
ACIONT INC $214,000 Grant Trans-NIH Recovery Act Research Support: Iontophoresis is a method of using a mild electrical current to enhance the penetration of a drug through tissue. Our long term goal is to develop the Visulex(r) ocular iontophoresis device capable of delivering large molecule anti-VEGF agents to the post Health and Human Services, Department of / National Institutes of Health 5/26/2010
SALK INSTITUTE FOR BIOLOGICAL STUDIES,THE $122,618 Grant Trans-NIH Recovery Act Research Support: The long-term goal of this project is to elucidate the mechanisms by which erbB2 regulates mammalian development. The erbB signaling network has been established as a key regulator of multiple developmental and physiological processes, including synaptic Health and Human Services, Department of / National Institutes of Health 6/22/2010
FEDERATION OF AMERICAN SCIENTISTS $100,000 Grant Trans-NIH Recovery Act Research Support: To supplement the development of the Computer game Immune Attack. Health and Human Services, Department of / National Institutes of Health 7/01/2010
NANOFIBER SOLUTIONS, LLC $199,365 Grant Trans-NIH Recovery Act Research Support: Project Title: High-Throughput Ex Vivo Tumor Cell Motility Assay. Malignant brain tumors are highly invasive leading to infiltration of the surrounding normal brain tissue. This makes them extremely difficult or impossible to ?cure? even after surgical re Health and Human Services, Department of / National Institutes of Health 7/01/2010
VYBION, INC. $200,000 Grant Trans-NIH Recovery Act Research Support: This project is for the development and testing of ProCode, a new technology for preclinical development of novel pharmaceutical therapies based on functional bispecific antibodies. It was described in the NIH Readiness Tool as A NEW TECHNOLOGY FOR PRECL Health and Human Services, Department of / National Institutes of Health 5/14/2010
AUTISM SPEAKS INC. $141,029 Grant Trans-NIH Recovery Act Research Support: This supplement (3RC1MH089707-01S1 - Linking Data Sources from the Autism Genetic Resource Exchange (AGRE) with NDAR) proposes to further enhance the breadth of data that will be made available to NDAR by facilitating the inclusion of clinical, genetic, a Health and Human Services, Department of / National Institutes of Health 5/22/2010
WESTERN WASHINGTON UNIVERSITY $24,679 Grant Trans-NIH Recovery Act Research Support: The synthetic versality of the C-B bond has let to its use in the synthesis of countless natural products and pharmaceuticaltargets. New methods to incorporate boron substituents into organic substrates would increase the types of molecules that could be Health and Human Services, Department of / National Institutes of Health 6/25/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $218,863 Grant Trans-NIH Recovery Act Research Support: Immunobiology of Acute Environmental Asthma - ARRA The majority of asthma exacerbations are a result of initiation of innate immune processes due to the encounter of pathogen-associated molecular patterns (PAMPs), such as bacterial or viral structures. T Health and Human Services, Department of / National Institutes of Health 6/28/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $1,499,999 Grant Trans-NIH Recovery Act Research Support: The proposed research will implement real-time radiology decision support and study its effects on the dissemination and adoption of imaging-related comparative effectiveness research (CER) findings. The development and broad adoption of advanced imaging Health and Human Services, Department of / National Institutes of Health 9/25/2010
ZYMO RESEARCH CORP $16,966 Contract : NIAID will purchase 16 of the R1041 ZR-96 Viral RNA kits and 24 of the D4022 ZR-96 Zymoclean Gel DNA Reccovery kit from Zymo Research Corporation. Health and Human Services, Department of / National Institutes of Health 9/24/2010
UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE $75,706 Grant Trans-NIH Recovery Act Research Support: The aims of the supplement for the parent grant 5 R01 DK062267 titled Neuronal Excitability and Motility in Colitis are (1) to use calcium imaging to evaluate neuromuscular function in the ulcerated region of TNBS-inflamed colon, which is a region in whic Health and Human Services, Department of / National Institutes of Health 9/09/2009
JOHNS HOPKINS UNIVERSITY, THE $100,040 Grant Trans-NIH Recovery Act Research Support: Persons in the US with end stage renal disease (ESRD) have an annual mortality rate of over 20% and an age-specific death rate from cardiovascular disease that is 10-100 times higher than the general population. Much of this excess mortality is due to sud Health and Human Services, Department of / National Institutes of Health 9/30/2010
MICHIGAN STATE UNIVERSITY $191,192 Grant Trans-NIH Recovery Act Research Support: The long-term objective of this study is to develop and test parental feeding strategies to reduce childhood obesity and improve diet quality among low-income groups. Specifically, this grant supports development and testing of a video-based interactive e Health and Human Services, Department of / National Institutes of Health 9/07/2010
BRIGHAM AND WOMEN'S HOSPITAL, INC., THE $262,320 Grant Trans-NIH Recovery Act Research Support: The objective of this collaborative and synergistic program is to determine how interactions between immigrant neutrophils and macrophages and resident synovial fibroblasts lead to the formation of synovial pannus and joint destruction. Preliminary result Health and Human Services, Department of / National Institutes of Health 7/06/2010
SAPIENT GOVERNMENT SERVICES, INC. $383,541 Contract : To acquire professional Information Technology (IT) services to support the National Institutes of Health national Database for Autism Research (NDAR) Progr;am in the areas of project management, system architecture, requirements agathering and system tes Health and Human Services, Department of / National Institutes of Health 5/28/2010
SRI INTERNATIONAL $1,046,974 Grant Trans-NIH Recovery Act Research Support: The goal of the project is to create improved treatment regimens for XDR/MDR-TB infections that will be shorter and have fewer side effects. The development of a shorter, more effective treatment regimen will increase patient compliance and therefore slo Health and Human Services, Department of / National Institutes of Health 8/30/2010
TEXAS TECH UNIVERSITY SYSTEM $311,059 Grant Trans-NIH Recovery Act Research Support: The objective of this grant is to investigate the effects of a specific interview technique on the quality of low-income childrenG??s reports about witnessed events. Additionally, we are investigating the effects of various child and contextual factors on Health and Human Services, Department of / National Institutes of Health 7/14/2010
PROTEOS INC $169,643 Grant Trans-NIH Recovery Act Research Support: The efficacy of injected therapeutic proteins is often compromised by their rapid clearance from the circulation. This means that doses must be administered more often, impacting both patient compliance and cost of treatment. A major search is underway i Health and Human Services, Department of / National Institutes of Health 7/09/2010
EMORY UNIVERSITY $277,495 Grant Trans-NIH Recovery Act Research Support: AMYGDALA: SEX DIFFERENCES IN BEHAVIOR, COGNITION, This is a competitive revision proposal of currently funded R01-MH050268 entitled G?Amygdala sex differences in behavior cognition and neuroendocrine developmentG? in response to NOT-OD-10-032 entitled G?N Health and Human Services, Department of / National Institutes of Health 9/27/2010
CASE WESTERN RESERVE UNIVERSITY $14,004 Grant Trans-NIH Recovery Act Research Support: This study will define mucosal virulence and mechanism of innate immune host defense against aerosolized Rift Valley fever virus, a Category A biodefense pathogen. Rift Valley Fever virus (RVFV) is designated a priority pathogen based upon its projected s Health and Human Services, Department of / National Institutes of Health 5/24/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $1,464,387 Grant Trans-NIH Recovery Act Research Support: Unfortunately, most individuals do not express protective HLA class I alleles such as B57 and B27, and are thus unable to control viral replication and disease progression. Understanding the mechanisms of this control might facilitate instilling these pr Health and Human Services, Department of / National Institutes of Health 8/02/2010
UNIVERSITY OF MASSACHUSETTS $290,676 Grant Trans-NIH Recovery Act Research Support: The purpose of this administrative supplement is to accelerate the analysis of human immune responses to category A-C viral pathogens. The overall objectives of the UMMS Collaborating Center for Translational Research on Human Immunology and Biodefense ar Health and Human Services, Department of / National Institutes of Health 8/23/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $542,671 Grant Trans-NIH Recovery Act Research Support: The major goal of this research proposal is to study the underlying neural mechanisms of overlapping pain. Our preliminary data indicates that neonatal chronic cystitis in rats causes significant colonic hyperalgesia later in their life. Based on our pr Health and Human Services, Department of / National Institutes of Health 8/19/2010
ALBERT EINSTEIN COLLEGE OF MEDICINE $499,999 Grant Trans-NIH Recovery Act Research Support: Malaria remains a major source of morbidity and mortality worldwide. The mechanisms of severe malaria which is associated with a 15% mortality rate and the mechanisms of natural immunity remain poorly defined. The immune response is central to these impor Health and Human Services, Department of / National Institutes of Health 9/29/2010
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH $74,400 Contract : Memorial Sloan Kettering Cancer Center has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of lung specimens (N=48). The collection of the specimens i Health and Human Services, Department of / National Institutes of Health 6/15/2010
WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION $171,759 Grant Trans-NIH Recovery Act Research Support: COBRE Transitional Center in Neuroscience - Pilot Project. Two related pilot projects are proposed to improve the capability of non-linear optical microscopy (NLOM), which has increasing application in biology. The first project will explore strategies Health and Human Services, Department of / National Institutes of Health 9/09/2010
OREGON HEALTH & SCIENCE UNIVERSITY $89,423 Grant Trans-NIH Recovery Act Research Support: Progression and metastasis of solid tumors is a principal cause of death for cancer patients. The childhood muscle cancer alveolar rhabdomyosarcoma is a classic example. A gap in understanding the disease-specific mechanisms of progression underlies the d Health and Human Services, Department of / National Institutes of Health 9/14/2010
DUKE UNIVERSITY $73,415 Grant Trans-NIH Recovery Act Research Support: Chromosome 22q11.2 deletion syndrome is the most common chromosome microdeletion syndrome in human beings and results in multiple medical problems and neurocognitive deficits. These neurocognitive deficits adversely affect functions that are critical to t Health and Human Services, Department of / National Institutes of Health 9/24/2010
SAI INTERACTIVE, INC. $159,698 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Approximately 50% of prescription medications are not taken as directed. The Institute of Medicine and others have highlighted the importance of improving prescription drug management in the United States, particularly Health and Human Services, Department of / National Institutes of Health 9/30/2010
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH $446,875 Contract : MSKCC has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of kidney tissues (200 cases). These cases are all primary and untreated. The collection of Health and Human Services, Department of / National Institutes of Health 4/21/2010
UNIVERSITY OF CALIFORNIA, IRVINE $753,221 Grant Trans-NIH Recovery Act Research Support: Celiac disease (gluten-sensitive enteropathy, celiac sprue) is a common disease with significant morbidity and mortality. It is caused by sensitivity to the dietary protein gluten, resulting in a chronic enteropathy in the small intestine. Celiac disease Health and Human Services, Department of / National Institutes of Health 7/15/2010
NORTHWESTERN UNIVERSITY $1,486,857 Grant Trans-NIH Recovery Act Research Support: Microbial translocation as a cause of systemic immune activation: Systemic immune activation has been shown to correlate with the rate of HIV disease progression. The underlying causes of such immune activation remain unclear, however. In chronic HIV infe Health and Human Services, Department of / National Institutes of Health 8/30/2010
UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC. $482,034 Grant Trans-NIH Recovery Act Research Support: Organic synthesis provides access to novel chemical entities essential for human health research as biological probes, libraries for high-throughput screening, and even as drug candidates. However, traditional chemical methodology development and reaction Health and Human Services, Department of / National Institutes of Health 7/22/2010
CREIGHTON UNIVERSITY $58,476 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION - With a long-term goal to better understand the molecular mechanisms of epithelial innate immune responses to pathogens, we will investigate innate immunity in cholangiocytes (epithelial cells lining the biliary tract) in response to Cryptosp Health and Human Services, Department of / National Institutes of Health 9/29/2010
UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO $705,626 Grant Trans-NIH Recovery Act Research Support: There is growing evidence that the host genetic make-up of an individual is a strong determinant of HIV/AIDS susceptibility. We have integrated genetics, immunology, and evolution, and used them as powerful tools to (a) uncover complex host gene-gene inte Health and Human Services, Department of / National Institutes of Health 9/07/2010
UNIVERSITY OF MARYLAND $54,200 Grant Trans-NIH Recovery Act Research Support: The University of Maryland Baltimore Institutional Review Board - National Health Research Ethics Committee of Nigeria (NHREC) Collaborative Capacity Building Initiative (UMBINN) is a program designed to enhance the capacity of the two ethics review commi Health and Human Services, Department of / National Institutes of Health 9/24/2010
CASE WESTERN RESERVE UNIVERSITY $235,500 Grant Trans-NIH Recovery Act Research Support: Sushi domain containing protein 4 (SUSD4) is a highly conserved (> 95% homology in mammals) hypothetical protein with unknown function. Previous microarray based comparative genomic hybridization (cGH) studies suggested that deletion of SUSD4 gene could Health and Human Services, Department of / National Institutes of Health 9/27/2010
RESEARCH FOUNDATION FOR MENTAL HYGIENE INC $236,998 Grant Trans-NIH Recovery Act Research Support: To support research and other projects that will support fundamental biomedical discovery and translation of that knowledge into effective prevention strategies and new treatments while also providing economic stimulus to the nation. Health and Human Services, Department of / National Institutes of Health 9/23/2010
UNIVERSITY OF HOUSTON SYSTEM $168,750 Grant Trans-NIH Recovery Act Research Support: The proposed project is designed to uncover the neural correlates of processing two languages as bilinguals transition from novice to intermediate L2 speakers in early childhood. To achieve this, the proposed project will use Near Infrared Spectroscopy ( Health and Human Services, Department of / National Institutes of Health 9/24/2010
KITWARE, INC. $150,000 Contract : This award is to acquire non-severable Professional Information Technology Services using ARRA Funds for the 2010 Algorithm, Adapters and Data Distribution Outreach. Health and Human Services, Department of / National Institutes of Health 8/05/2010
IQUUM, INC. $1,872,460 Grant Trans-NIH Recovery Act Research Support: We propose to develop a Liat(tm) Avian Influenza Assay to enable the specific detection and differentiation of potential pandemic avian influenza A/H5, A/H7 and A/H9 in less than 25 minutes. We will also develop a high throughput Liat Workstation and upgr Health and Human Services, Department of / National Institutes of Health 9/11/2009
UNIVERSITY OF ALABAMA AT BIRMINGHAM $349,231 Grant Trans-NIH Recovery Act Research Support: While Fc receptors (FcRs) for switched immunoglobulin isotypes have been extensively characterized, an FcR for IgM (Fc-?R) has defied genetic identification. By retroviral expression and functional cloning, we have recently identified a cDNA encoding a Health and Human Services, Department of / National Institutes of Health 7/26/2010
NATIONAL JEWISH HEALTH $396,250 Grant Trans-NIH Recovery Act Research Support: This bridge award will enable us to obtain some additional results towards a project originally submitted for 5 years of support, to further our understanding of the functions of the gamma/delta (gd) T cells, by identifying and characterizing common ligan Health and Human Services, Department of / National Institutes of Health 7/19/2010
GEORGIA HEALTH SCIENCES UNIVERSITY RESEARCH INSTITUTE, INC. $196,680 Grant Trans-NIH Recovery Act Research Support: Lymph node involvement is one of the most important clinical features to determine when managing colorectal cancer patients. Node-negative disease is often cured by surgery alone, whereas node-positive disease requires the administration of chemotherapy, Health and Human Services, Department of / National Institutes of Health 8/11/2010
UNIVERSITY OF CHICAGO, THE $384,624 Grant Trans-NIH Recovery Act Research Support: Although energy homeostasis is central in determining feeding behavior, the decision to eat or stop eating is largely controlled by the reward pathway. Research on the homeostatic system has been central to our understanding of energy balance and obesity, Health and Human Services, Department of / National Institutes of Health 8/11/2010
AXERION THERAPEUTICS, INC. $3,000,000 Grant Trans-NIH Recovery Act Research Support: Axerion seeks to develop therapeutic agents to promote the recovery of neurological function through axonal fiber growth and enhanced plasticity after brain or spinal cord damage. In nearly all neurological conditions, a substantial portion of brain and s Health and Human Services, Department of / National Institutes of Health 4/19/2010
HASKINS LABORATORIES, INC. $198,303 Grant Trans-NIH Recovery Act Research Support: Nature and Acquisition of the Speech Code and Reading. Administrative Supplement for HD-001994, Project III. Health and Human Services, Department of / National Institutes of Health 9/01/2010
APPLIED BIOMATHEMATICS INC $1,627,774 Grant Trans-NIH Recovery Act Research Support: Physicians and their patients will benefit from well designed software tools that compensate for these problems to (1) explain to patients the meaning of the results of a medical test in a way that is understandable and accurate, and (2) help patients dec Health and Human Services, Department of / National Institutes of Health 9/20/2010
IONWERKS, INC. $2,996,567 Grant Trans-NIH Recovery Act Research Support: Overall Goal:-Obtain maximum molecular information by Mass Spectrometry from a single 10 micron diameter cell. Ionwerks has created new classes of nanoparticulate (NP) matrices which can be localized in submonolayer amounts on or within the first several Health and Human Services, Department of / National Institutes of Health 8/23/2010
UNIVERSITY OF MARYLAND $135,693 Grant Trans-NIH Recovery Act Research Support: There is increasing evidence that antibodies targeting the CD4 induced (CD4i) epitopes on the HIV envelope spike can facilitate control of viremia and quite possibly protection from transmission after exposure (reviewed in (1, 2)). We have developed a gp1 Health and Human Services, Department of / National Institutes of Health 8/27/2010
THE HOSPITAL FOR SPECIAL SURGERY FUND INC $4,140,386 Grant Trans-NIH Recovery Act Research Support: We seek to identify common factors by which OA initiates and develops following normal loading of abnormal joint tissues (genetic model) or after abnormal loading of normal joints (post-traumatic/surgical model). Goal: To identify common factors by which Health and Human Services, Department of / National Institutes of Health 9/16/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $83,664 Grant Trans-NIH Recovery Act Research Support: Title: Targeted Gene Expression from NL63 Vaccine Vectors Project Description: Funds were requested to continue our work with the human coronavirus, NL63 as a heterologous vaccine vector that expresses foreign antigens from other respiratory pathogens at Health and Human Services, Department of / National Institutes of Health 9/29/2010
UNIVERSITY OF TEXAS HEALTHCARE AT TYLER $0 Grant Trans-NIH Recovery Act Research Support: This is a supplemental award for enhancing and accelerating our existed research: NIAID/NIH grant ?molecular basis for age-related thymic involution and rejuvenation? (R01-AI081995). In the first year of this R01 project, we established a thymic medullary Health and Human Services, Department of / National Institutes of Health 7/06/2010
DANA-FARBER CANCER INSTITUTE, INC. $97,907 Grant Trans-NIH Recovery Act Research Support: Progress in the research funded by this grant has led to the discovery that the Osteopontin gene specifies two distinct isoforms through differential translation of a single Opn RNA species: a cytokine in T cells and a critical intracellular protein expre Health and Human Services, Department of / National Institutes of Health 9/07/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $149,793 Grant Trans-NIH Recovery Act Research Support: The title of this award is Children Living in Rural Poverty: The Continuation of the Family Life Project. This award will fund the genotyping of approximately 100 candidate genes from children and mothers who currently participate in the Family Life Proj Health and Human Services, Department of / National Institutes of Health 9/01/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $108,957 Grant Trans-NIH Recovery Act Research Support: Young children differ in how quickly and effectively they master their native language, with these differences being connected to a variety of social and environmental factors. A well known observation is that vocabulary growth is related to the socio eco Health and Human Services, Department of / National Institutes of Health 8/10/2010
BOSTON COLLEGE, TRUSTEES OF $469,500 Grant Trans-NIH Recovery Act Research Support: Control of Early Embryonic Cell Polarity in a Model Deuterostome: Our results thus far include: he cytoskeleton is involved in the establishment and maintenance of the non-uniform distribution of membrane domains in the plasma membrane. It has been prev Health and Human Services, Department of / National Institutes of Health 6/25/2010
UNIVERSITY OF ARKANSAS SYSTEM $528,985 Grant Trans-NIH Recovery Act Research Support: The primary goal of the grant, 'Measuring Quality Adjusted life years in children with Autism Spectrum Disorders' , is to investigate methods of measuring quality adjusted life years (QALYS) for cost-effectiveness analysis of interventions to treat child Health and Human Services, Department of / National Institutes of Health 9/09/2010
OREGON HEALTH & SCIENCE UNIVERSITY $197,976 Grant Trans-NIH Recovery Act Research Support: This is a revised renewal application aimed at elucidating the neuroendocrine mechanisms underlying the initiation of female puberty. During the last funding period we examined the hypothesis that the activation of LHRH secretion at puberty requires a cel Health and Human Services, Department of / National Institutes of Health 7/27/2010
UNIVERSITY OF NEBRASKA $103,950 Grant Trans-NIH Recovery Act Research Support: Systemic lupus erythematosus (SLE) is a devastating disease that affecting 1 million people world wide. Due to the unknown etiology, there is no specific treatment currently available for SLE. The hallmark for SLE is the production of disease associated a Health and Human Services, Department of / National Institutes of Health 8/30/2010
UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON $100,874 Grant Trans-NIH Recovery Act Research Support: Immunoglobulin A (IgA) has been shown to be critical in mucosal immune defense. Intestinal IgA can be produced by both T cell-dependent and T cell-independent pathways, however, the relative importance of each and how they are regulated are still largely Health and Human Services, Department of / National Institutes of Health 9/29/2010
MAYO CLINIC $81,250 Contract : The Mayo Foundation has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of hepatocellular cases. These cases are all primary and untreated. The colle Health and Human Services, Department of / National Institutes of Health 8/27/2010
GEORGETOWN UNIVERSITY (THE) $49,877 Grant Trans-NIH Recovery Act Research Support: Project Summary Television viewing and picture-book reading are prevalent activities during toddlerhood (Rideout, Vandewater & Wartella, 2003). Parents and teachers assume that toddlers' can easily learn from these symbolic media by transferring new infor Health and Human Services, Department of / National Institutes of Health 8/10/2010
COLLEGE OF WILLIAM & MARY, THE $149,961 Contract : The purpose of this award is to acquire non-severable Professional Information Technology Services using ARRA Funds for the 2010 Algorithm, Adapters, and Data Distribution Outreach (A2D2) Project Title: 3D Real-Time Physics-Based Non-Rigid Registration fo Health and Human Services, Department of / National Institutes of Health 6/24/2010
RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE $139,133 Grant Trans-NIH Recovery Act Research Support: Perhaps the best predictor of ethanol abuse in adolescence and young adult humans is prior fetal exposure to the drug. Yet, there is a relative paucity of evidence regarding the factors contributing to these long-term ingestive consequences. Studies have Health and Human Services, Department of / National Institutes of Health 8/09/2010
CHILDREN'S HOSPITAL CORPORATION, THE $564,063 Grant Trans-NIH Recovery Act Research Support: Transcriptional regulators play pivotal roles in fundamental physiological processes including cell proliferation, differentiation and development. A main interest of my lab is to understand the biology and mechanism of action of Yin Yang 1 (YY1), a zinc Health and Human Services, Department of / National Institutes of Health 9/13/2010
NORTH DAKOTA STATE UNIVERSITY $179,659 Grant Trans-NIH Recovery Act Research Support: Object individuation is the ability to determine that an object is the same or different from an object previously seen. This ability provides a foundation for object recognition and is crucial to our perception of a stable and persistent world. Despite s Health and Human Services, Department of / National Institutes of Health 9/21/2010
UNIVERSITY OF MARYLAND $2,355,935 Grant Trans-NIH Recovery Act Research Support: We convene our investigators, sub-contractors and staff for weekly meetings focused on data quality, analysis and curriculum development.. Project staff and PIs have additional weekly meetings. ICF Macro is nearing completion of in-depth interviews and te Health and Human Services, Department of / National Institutes of Health 9/27/2010
JOHNS HOPKINS UNIVERSITY, THE $248,850 Contract : Johns Hopkins has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of lung adeno and squamous cell carcinoma tissue (119 cases). These cases are all prim Health and Human Services, Department of / National Institutes of Health 5/20/2010
UNIVERSITY OF NORTH CAROLINA AT GREENSBORO $139,500 Grant Trans-NIH Recovery Act Research Support: !Mothers' Part-Time Employment! is an analysis of NICHD ECCRN data (focal child birth through 5th grade) to identify the conditions under which mothers' part-time employment facilitates family functioning and the conditions under which mothers' part-time Health and Human Services, Department of / National Institutes of Health 4/06/2010
PURDUE UNIVERSITY $1,984,388 Grant Trans-NIH Recovery Act Research Support: A diversity of ideas reflects a diversity of individuals. Highly innovative solutions to emerging U.S. and global human health concerns requires a diverse biomedical workforce comprised of the nation's best minds. National efforts to diversify our biomedi Health and Human Services, Department of / National Institutes of Health 9/30/2010
CHILDREN'S HOSPITAL MEDICAL CENTER $1,813,081 Grant Trans-NIH Recovery Act Research Support: The long term objective of this proposal is to conduct a NexGen RNA-Seq based dissection of the gene expression program driving kidney development. The central thesis is straightforward. We propose to define, in a sensitive and quantitative manner, all o Health and Human Services, Department of / National Institutes of Health 9/29/2010
SEATTLE CHILDREN'S HOSPITAL $292,500 Grant Trans-NIH Recovery Act Research Support: The molecular and cellular mechanisms by which CD4+CD25+FoxP3+ T cells are induced and by which they inhibit induction of autoimmunity have not been elucidated. The role of this subset of T cells in the regulation of EAE, an animal model of Multiple Scler Health and Human Services, Department of / National Institutes of Health 8/26/2010
UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE $193,800 Grant Trans-NIH Recovery Act Research Support: The overall goal of this supplement proposal is to advance the aims and goals of the present Center of Biomedical Research Excellence (COBRE) P30 RR031158 (PI: Irvin) program is to create a sustainable center of research excellence in Lung Biology and Dis Health and Human Services, Department of / National Institutes of Health 9/20/2010
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $399,350 Grant Trans-NIH Recovery Act Research Support: The purpose of this study is to confirm the gene expression profile found to predict response to Revlimid in patients with myelodysplastic syndromes (MDS) irrespective of the patients' karyotype. The clinical trial that accompanies this study (ie the trea Health and Human Services, Department of / National Institutes of Health 9/06/2010
KAISER FOUNDATION HOSPITALS $937,264 Grant Trans-NIH Recovery Act Research Support: Traditional frequentist methods for analysis of clinical trials are generally accepted as the gold standard in research practice. Newer Bayesian methods, however, hold great promise for a more efficient analytic approach, thereby lowering the costs of cl Health and Human Services, Department of / National Institutes of Health 9/20/2010
UNIVERSITY OF CALIFORNIA, IRVINE $105,100 Grant Trans-NIH Recovery Act Research Support: A variety of drug discovery efforts are focused on creation of molecules that will increase nicotinic cholinergic neurotransmission to augment cognition in the dementias. In addition to the nicotinic system, GABAA receptors containing the alpha5 subunit ( Health and Human Services, Department of / National Institutes of Health 9/14/2010
UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE $142,411 Grant Trans-NIH Recovery Act Research Support: The University of Vermont (UVM) has a long and venerable history of research using rodent models of environmental lung disease developed within a dedicated inhalational exposure facility housed in the College of Engineering at UVM. This facility has been Health and Human Services, Department of / National Institutes of Health 9/20/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $200,000 Grant Trans-NIH Recovery Act Research Support: Most dialysis patients in the US are >65 years and are at increased cardiovascular risk. The prevalence of atrial fibrillation (AF) is higher in dialysis patients, but estimates vary widely (7%-27%). Further, controversy persists in defining its optimal m Health and Human Services, Department of / National Institutes of Health 9/13/2010
LOUISIANA STATE UNIVERSITY SYSTEM $91,612 Grant Trans-NIH Recovery Act Research Support: The objective for this administrative supplement is to improve the insight gained from comparative gene expression measurements in embryos exposed to the environment of maternal diabetes by (i) generating a broader view and greater significance of diabete Health and Human Services, Department of / National Institutes of Health 7/08/2010
UNIVERSITY OF MIAMI $94,050 Grant Trans-NIH Recovery Act Research Support: Our parent project (R0-1GM083897) involves studying the role of the novel DNA-binding and dimerization (DBD) domain of MAP kinase phosphatase 5 (MKP5) phosphatase in regulating gene transcription pertinent to cellular activities such as cell growth, cell Health and Human Services, Department of / National Institutes of Health 8/25/2010
UNIVERSITY OF MASSACHUSETTS $411,250 Grant Trans-NIH Recovery Act Research Support: T cell development in the thymus is now known to produce a wide array of distinct T cell lineages. Many of these T cell subsets play key roles in regulating immune responses, both to self as well as to pathogens. In addition to the conventional CD4+ and Health and Human Services, Department of / National Institutes of Health 9/30/2010
BRIGHAM AND WOMEN'S HOSPITAL, INC., THE $1,500,000 Grant Trans-NIH Recovery Act Research Support: While technologic advances in imaging techniques such as US, CT, and MRI have contributed tremendously to patient care, expenditures related to their use have increased rapidly and significant practice pattern variation exists in imaging utilization. Subs Health and Human Services, Department of / National Institutes of Health 9/25/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $1,492,184 Grant Trans-NIH Recovery Act Research Support: There is increased interest in comparative effectiveness research as a way of informing clinicians, payers, and policymakers about the relative effectiveness of different treatments with the goal of maximizing benefit to patients and value to payers. Alth Health and Human Services, Department of / National Institutes of Health 9/27/2010
UNIVERSITY OF CONNECTICUT $207,828 Grant Trans-NIH Recovery Act Research Support: Early detection of Autism Spectrum Disorders (ASD) has come to be recognized as a crucial activity in promoting the best possible outcome for affected children. In our current NICHD-funded Early Detection (ED) study, for which this application is a compet Health and Human Services, Department of / National Institutes of Health 8/25/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $46,400 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The broad objective of the proposed research is to obtain a molecular-level understanding of the interactions between transcriptional activators and their target proteins within the transcriptional machinery using a su Health and Human Services, Department of / National Institutes of Health 8/13/2010
REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE $331,923 Grant Trans-NIH Recovery Act Research Support: We will accelerate the goals of the parent grant by including 2 new academic statistical collaborators and a statistics graduate student, and 2 new staff. This expansion will help the Berkeley GDAC to match the productive power of the rest of the TCGA pr Health and Human Services, Department of / National Institutes of Health 9/21/2010
THE VANDERBILT UNIVERSITY $97,873 Grant Trans-NIH Recovery Act Research Support: Development of the vertebrate brain requires the appropriate specification, migration, and differentiation of neurons. As a model organism for studying these events, we use the zebrafish, because the genetic, molecular and embryological tools available gi Health and Human Services, Department of / National Institutes of Health 7/08/2010
HENRY FORD HEALTH SYSTEM $732,500 Grant Trans-NIH Recovery Act Research Support: Gliomas, the most frequent primary brain tumors, exhibit very poor prognosis which is largely due to their highly infiltrative nature. Genetic and biochemical studies have demonstrated that gliomagenesis involves stepwise accumulation of genetic alteratio Health and Human Services, Department of / National Institutes of Health 9/20/2009
CYTOKINETICS, INCORPORATED $2,948,895 Grant Trans-NIH Recovery Act Research Support: Cytokinetics, Inc. is a clinical-stage biopharmaceutical company focused on the discovery and development of novel small molecule therapeutics that modulate muscle function for the potential treatment of serious diseases and medical conditions. A central Health and Human Services, Department of / National Institutes of Health 7/23/2010
TEXAS BIOMEDICAL RESEARCH INSTITUTE $735,903 Grant Trans-NIH Recovery Act Research Support: Pre-eclampsia/eclampsia (PE/E) is the most common and serious disorder of human pregnancy and is associated with substantial maternal and perinatal morbidity and mortality. There is currently no known prevention or cure for PE/E with the only effective tr Health and Human Services, Department of / National Institutes of Health 8/25/2010
BAYLOR COLLEGE OF MEDICINE $184,220 Grant Trans-NIH Recovery Act Research Support: Adult stem cells are present in many tissues and replenish the cellular constituents of those tissues throughout life. Recently, evidence has accumulated that at least under some conditions, progeny of adult stem cells can generate cells outside their tis Health and Human Services, Department of / National Institutes of Health 9/28/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $240,000 Grant Trans-NIH Recovery Act Research Support: The matrix metallo proteases (MMPs) are a large family of enzymes that have been found to regulate the pathogenesis of a wide rage of human diseases, most notably cancer. Their potential role in matrix degradation during tumor growth originally made them Health and Human Services, Department of / National Institutes of Health 8/27/2010
LOMA LINDA UNIVERSITY $676,510 Grant Trans-NIH Recovery Act Research Support: The use of pigs as organ donors for human transplantation represents a solution to the escalating shortage of organs that are available for patients with endstage diseases. Wild type pig organs are hyperacutely rejected, however, by preexisting natural an Health and Human Services, Department of / National Institutes of Health 8/30/2010
SCHEPENS EYE RESEARCH INSTITUTE, INC., THE $1,224,824 Grant Trans-NIH Recovery Act Research Support: During this the first year of the stimulus grant we studied the therapeutic effect of in vivo injection of ACAID induced Tolerogenic APC on the clinical course of Experimental Autoimmune Uveitis ( EAU) in the C57/B6 mouse. We observed that the antigen Health and Human Services, Department of / National Institutes of Health 7/17/2009
KITWARE, INC. $1,224,993 Contract : The Insight Toolkit, Version 4 and Professional Services: 'Fostering Open Science for Lung Cancer Lesion Sizing'. The Insight Toolkit (ITK) is an open source software library that provides functionalities for performing medical image analysis, in particul Health and Human Services, Department of / National Institutes of Health 9/28/2010
WESTERN CAROLINA UNIVERSITY $325,729 Grant Trans-NIH Recovery Act Research Support: Overall purpose and expected outcomes. We are studying S-(2-succinyl)- modified thiols as models of modified proteins observed in diabetic patients. Metal complexes formed with these modified proteins have been proposed to catalyze oxidative stress lead Health and Human Services, Department of / National Institutes of Health 7/09/2010
UNIVERSITY OF MARYLAND $210,144 Grant Trans-NIH Recovery Act Research Support: The proposed supplement will augment the aims of the parent award (R37HD17899) by examining social, emotional, and behavioral outcomes in children during the transition to middle childhood. In order to complete data collection within one year, as well as Health and Human Services, Department of / National Institutes of Health 7/27/2010
RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE $5,370,429 Grant National Center for Research Resources, Recovery Act Construction Support: The first products of genes (DNA) are the ribonucleic acids, RNAs. Every cell has many different types of RNA molecules. Interest in RNA has increased exponentially with each new discovery of its functions. The great majority ... Show more Health and Human Services, Department of / National Institutes of Health 9/23/2010
UNIVERSITY OF CHICAGO, THE $80,421 Grant Trans-NIH Recovery Act Research Support: Necrotizing enterocolitis (NEC) is a life-threatening inflammatory bowel disorder of unknown cause that affects approximately 10% of premature infants born <1500gm. Prematurity is the greatest risk factor rather than any particular insult, suggesting that Health and Human Services, Department of / National Institutes of Health 7/27/2010
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $149,885 Grant Trans-NIH Recovery Act Research Support: 'This supplement was awarded on September 15, 2010. The following progress has been made: 1. Subcontract to the Public Health Institute has been prepared and submitted to Sponsored Projects Administration at Columbia. 2. We have spoken to our colleagues Health and Human Services, Department of / National Institutes of Health 9/09/2010
LUMEN THERAPEUTICS, LLC $195,859 Grant Trans-NIH Recovery Act Research Support: Patients with kidney failure must undergo regular external blood filtering, known as hemodialysis, in order to remove metabolic byproducts from their blood. Hemodialysis requires creation of access sites in the body for connection to hemodialysis machine Health and Human Services, Department of / National Institutes of Health 9/29/2010
UNIVERSITY OF MIAMI $422,957 Grant Trans-NIH Recovery Act Research Support: Miami HIV/AIDS Clinical Therapeutic and Vaccine Trial Unit: Immunopathogenesis of Immune Reconstitution Syndrome. Immune Reconstitution Inflammatory Syndrome (IRIS) among patients with HIV infection is defined as a paradoxical infectious or inflammatory Health and Human Services, Department of / National Institutes of Health 8/30/2010
UNIVERSITY OF KENTUCKY $101,106 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Obesity and type 2 diabetes are conditions characterized by a state of chronic, low-grade inflammation, due largely to an increase in adipose tissue inflammation brought about by infiltrating macrophages. Drugs such as Health and Human Services, Department of / National Institutes of Health 7/19/2010
AGILENT TECHNOLOGIES, INC $514,520 Contract : 60ea - G41121 Whole Human Genome kit 4x44K, 5 slides, 60ea - G4122F Whole Mouse Genome kit 4x44K, 5 slides, 100sl - G2519F Unrestricted AMADID Release GE 4x44K, 100sl - G2519F Unrestricted AMADID Release GE 4x44K, 1ea - G2939AA 2100 Electrophoresis Bioana Health and Human Services, Department of / National Institutes of Health 9/22/2010
REGENTS OF THE UNIVERSITY OF MINNESOTA $458,770 Grant Trans-NIH Recovery Act Research Support: The human immune response to infection and immunization - Profiling via modern immunological methods and systems biology. The Hepatitis B subunit vaccine induces immunity in millions of people by inducing antibodies that prevent viral infection. However, Health and Human Services, Department of / National Institutes of Health 9/27/2010
BAYLOR COLLEGE OF MEDICINE $1,956,173 Grant Trans-NIH Recovery Act Research Support: The comparative effectiveness (CE) of screening endoscopy in patients with GERD symptoms (vs. no screening) or among different surveillance strategies (frequency, intensity) is unclear due to lack of strong evidence-based findings for GERD or Barrett's es Health and Human Services, Department of / National Institutes of Health 9/30/2010
DANA-FARBER CANCER INSTITUTE, INC. $763,750 Grant Trans-NIH Recovery Act Research Support: The development of an effective HIV vaccine is one of the greatest global health challenges. However despite decades of research, no vaccine has yet been able to elicit protective immunity to HIV. Recently, efforts to develop vaccines against HIV have foc Health and Human Services, Department of / National Institutes of Health 9/30/2010
FLORIDA INTERNATIONAL UNIVERSITY $60,471 Grant Trans-NIH Recovery Act Research Support: Mosquito-transmitted parasitic diseases are among the major causes of mortality and morbidity in the world. Recent dramatic increases in the incidence of mosquito-borne diseases, like malaria and dengue fever, and the wide-spread resistance of mosquitoes Health and Human Services, Department of / National Institutes of Health 7/06/2010
JOSLIN DIABETES CENTER, INC. $399,109 Grant Trans-NIH Recovery Act Research Support: Mechanism-Based Biomarkers for Glucose-Lowering in TINSAL T2D - Background. TINSAL-T2D is a multicenter, randomized, placebo-controlled, dose-ranging clinical trial designed to determine glycemic efficacy, safety and tolerability of salsalate in patients Health and Human Services, Department of / National Institutes of Health 9/30/2010
UNIVERSITY OF ALABAMA AT BIRMINGHAM $36,369 Grant Trans-NIH Recovery Act Research Support: A supplement was requested to hire a research assistant to analyze samples collected through the parent grant. The research assistant hired through supplemental funds will oversee three major tasks: 1) establishing the laboratory and managing daily opera Health and Human Services, Department of / National Institutes of Health 8/09/2010
ALBERT EINSTEIN COLLEGE OF MEDICINE $903,499 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Community-based organizations and academic health centers each have unique resources, assets and expertise which could be used synergistically to promote health in the community by enhancing opportunities for health-re Health and Human Services, Department of / National Institutes of Health 7/06/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $329,000 Grant Trans-NIH Recovery Act Research Support: Inflammatory bowel disease, enterocolitis, colorectal cancer, Celiac sprue, and radiation injury are associated with damage to the intestinal epithelial barrier. The multifactorial nature of these pathologies, and the lack of targeted therapies for th Health and Human Services, Department of / National Institutes of Health 7/22/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $2,079,278 Grant Trans-NIH Recovery Act Research Support: High-resolution, three-dimensional atomic resolution structures obtained by x-ray macromolecular crystallography provide fundamental insights into the molecular mechanisms of proteins, nucleic acids, and their higher-order complexes. This information is e Health and Human Services, Department of / National Institutes of Health 6/24/2010
UNIVERSITY OF CONNECTICUT $103,108 Grant Trans-NIH Recovery Act Research Support: The double-stranded (ds) RNA-activated protein kinase, PKR, is one of several proteins induced by interferon and plays a pivotal role in the cellular antiviral response. PKR has also been implicated in other cellular processes including transformation, di Health and Human Services, Department of / National Institutes of Health 7/26/2010
UNIVERSITY OF MAINE SYSTEM $76,209 Grant Trans-NIH Recovery Act Research Support: This proposal engages high school and undergraduate students in summer employment in a research program designed to encourage and stimulate them to pursue a career in health-related science. Health and Human Services, Department of / National Institutes of Health 5/28/2010
SOUTH CAROLINA RESEARCH FOUNDATION $399,446 Grant Trans-NIH Recovery Act Research Support: Multi-Component Intervention to Increase Physical Activity in Preschool Children Obesity rates in 3-5 year-old American children have increased dramatically in recent decades. Concurrent with this alarming trend, time spent by young children in preschool Health and Human Services, Department of / National Institutes of Health 9/01/2010
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. $120,000 Grant Trans-NIH Recovery Act Research Support: Rhizobium-legume symbioses involve processes that are fundamental to all bacterial-host interactions. These include (a.) prokaryotic-eukaryotic recognition, (b.) interaction with the host defense mechanism, and (c.) bacterial and host differentiation proc Health and Human Services, Department of / National Institutes of Health 1/22/2010
UNIVERSITY OF ARKANSAS SYSTEM $185,637 Grant Trans-NIH Recovery Act Research Support: With continuous improvements in cancer treatment, there is a growing population of long-term cancer survivors who are at a significant risk for late effects induced by ionizing radiation (IR) and chemotherapy, such as residual bone marrow (BM) injury, gen Health and Human Services, Department of / National Institutes of Health 9/17/2010
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH $170,000 Contract : The Sloan Kettering Institute for Cancer Research has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) Projects. Specifically this award is to fund the provision of bladder tissues (100 cases). These cases are Health and Human Services, Department of / National Institutes of Health 7/14/2010
CLEMSON UNIVERSITY $438,454 Grant Trans-NIH Recovery Act Research Support: The objectives of this prospective investigation are to use latent growth mixture modeling to determine the longitudinal trajectories of sexual violence (SV) behaviors during college and to use the Theory of Triadic Influence to guide the assessment of in Health and Human Services, Department of / National Institutes of Health 7/19/2010
BAYLOR COLLEGE OF MEDICINE $1,799 Grant Trans-NIH Recovery Act Research Support: We will study decision-making processes in physicians under controlled experimental conditions, paired with the neuroimaging data. Litt Health and Human Services, Department of / National Institutes of Health 9/21/2010
EMORY UNIVERSITY $499,863 Grant Trans-NIH Recovery Act Research Support: Tranplant Tolerance in Non-Human Primates For most patients with end stage renal disease, organ transplantation is the preferred therapy. Recent evidence suggests antibody-mediated rejection is a growing problem in clinical transplantation. The goal of th Health and Human Services, Department of / National Institutes of Health 7/26/2010
UNIVERSITY OF TOLEDO, THE $207,653 Grant Trans-NIH Recovery Act Research Support: Award Description* DESCRIPTION (provided by applicant): Abstract Prenatal alcohol exposure induces neuronal death in the fetal brain through apoptotic mechanism. Evidence shows that alcohol exposure may accelerate apoptosis in the developing brain through Health and Human Services, Department of / National Institutes of Health 9/06/2010
GEORGETOWN UNIVERSITY (THE) $176,858 Grant Trans-NIH Recovery Act Research Support: This application is for the purchase of a self-contained x-ray machine that will be based in the radiobiology program of the Lombardi Comprehensive Cancer Center (LCCC) and that will be a core resource for members of the LCCC as well as for other research Health and Human Services, Department of / National Institutes of Health 8/05/2010
EMORY UNIVERSITY $97,439 Grant Trans-NIH Recovery Act Research Support: DNA Methylation: Structures, Functions, and regulation The major goal of this project is to continue the investigation of functional role of posttranslational modifications of mammalian DNA methyltransferases (Dnmts) in epigenetic regulation of gene expre Health and Human Services, Department of / National Institutes of Health 9/30/2010
UNIVERSITY OF CHICAGO, THE $100,000 Grant Trans-NIH Recovery Act Research Support: The South Side of Chicago is a 95 square mile region including 34 of Chicago's 77 community areas, and is one of the nation's largest contiguous urban African American communities (72% of 1.1 million people). Seven of the 8 poorest communities in Chicago Health and Human Services, Department of / National Institutes of Health 8/09/2010
BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE $1,999,788 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This is the third competitive renewal of our Program Project Grant. We have modified the name to reflect the refinement in focus, Antibody Targeted Radiation and Immunotherapy for the Treatment of Solid Tumors. There a Health and Human Services, Department of / National Institutes of Health 9/29/2010
ALLENTOWN INC $49,634 Contract : Manufacture and ship the following items: 92 Ea. PCT4SMV-4L 92 EA. MBTT4ST4K-PNC 92 EA. F45GPB-NIH 92 EA. 311811 Caging systems to be used in Ventilated ferret units. Health and Human Services, Department of / National Institutes of Health 9/08/2010
MARINE BIOLOGICAL LABORATORY, THE $233,013 Grant Trans-NIH Recovery Act Research Support: This application re-examines the mechanism of glucose stimulated insulin secretion from pancreatic beta cells. Based on our preliminary studies, we have identified a novel metabolic pathway, which involves plasma membrane electron transport, and is respon Health and Human Services, Department of / National Institutes of Health 9/30/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $109,017 Grant Trans-NIH Recovery Act Research Support: The Kissi gene encodes proteins called kisspeptins, v^rhich bind to the G-protein coupled receptor GPR54. Kissl is expressed in discrete brain regions that regulate reproductioa and in mammals, induding humans, kisspeptins stimulate the secretion of gonad Health and Human Services, Department of / National Institutes of Health 8/18/2010
VISION MECHANICS, INC $40,000 Contract : Upgrade PALM Microscope System Health and Human Services, Department of / National Institutes of Health 5/26/2010
UNIVERSITY OF ARIZONA $880,052 Grant Trans-NIH Recovery Act Research Support: Individuals with astigmatism (unequal curvature of one or more of the surfaces of the eye) experience blurred vision when not wearing corrective lenses. The visual experience of the uncorrected astigmat provides a unique natural experiment on the effect Health and Human Services, Department of / National Institutes of Health 8/04/2010
OREGON HEALTH & SCIENCE UNIVERSITY $495,816 Grant Trans-NIH Recovery Act Research Support: Comparative effectiveness research will play a crucial role in shaping national health care reform by investigating and identifying mechanisms to improve quality, reduce the cost of care, and conduct primary research that responds to the needs of patients Health and Human Services, Department of / National Institutes of Health 9/30/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $87,306 Grant Trans-NIH Recovery Act Research Support: Bone histomorphometry is the gold standard method used in the field to measure static and dynamic parameters of bone remodeling. The information garnered complements biochemical studies since it provides a direct in vivo measurement of cell numbers and bo Health and Human Services, Department of / National Institutes of Health 7/27/2010
BRIGHAM AND WOMEN'S HOSPITAL, INC., THE $904,314 Grant Trans-NIH Recovery Act Research Support: We are seeking support to establish a Genome Characterization Center, as a part of the Cancer Genome Atlas Project in Boston. The goal of the proposed effort is to analyze 2,000-2,500 tumor samples each year over a five-year period of time and identify a Health and Human Services, Department of / National Institutes of Health 9/16/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $35,000 Grant Trans-NIH Recovery Act Research Support: In order to generate a functional nervous system, neural progenitors need to adopt one specific fate verses another. It is the long-term goal of my laboratory to determine the molecular mechanisms that regulate cell fate determination of neural crest and Health and Human Services, Department of / National Institutes of Health 7/07/2010
EMPIRICAL TECHNOLOGIES CORP $113,956 Grant Trans-NIH Recovery Act Research Support: Falls among the elderly, one of the most common reasons requiring medical intervention and a contributing factor in 40% of nursing home admissions, are a major health problem. Several studies have identified quantifiable gait markers that appear to distin Health and Human Services, Department of / National Institutes of Health 3/15/2010
SCRIPPS RESEARCH INSTITUTE, THE $744,332 Grant Trans-NIH Recovery Act Research Support: The new scientific project described in this administrative supplement application is designed to advance in a complementary fashion the primary objectives of our original U19 award -the discovery and validation of biomarkers for kidney transplantation an Health and Human Services, Department of / National Institutes of Health 9/07/2010
UNIVERSITY OF CALIFORNIA, IRVINE $1,248,355 Grant Trans-NIH Recovery Act Research Support: Methicillin-Resistant Staphylococcus aureus (MRSA) produces significant morbidity and mortality among a large and growing population of hospitalized and chronically ill patients in the US. As invasive disease due to MRSA continues to rise, there is an urg Health and Human Services, Department of / National Institutes of Health 8/30/2010
NEXTBIO $207,750 Grant Trans-NIH Recovery Act Research Support: We propose to continue the development of our novel application that enables scientists to search and correlate information across studies in different model organisms. NextBio will develop methods that combine the power of genomic and proteomic studies i Health and Human Services, Department of / National Institutes of Health 7/01/2010
WASHINGTON UNIVERSITY, THE $275,212 Grant Trans-NIH Recovery Act Research Support: This proposal requests funds to establish a Whole Slide Imaging (WSI) facility for NIH-funded translational neuroscience research at Washington University. Whole slide imaging rapidly captures the entire content of glass histology slides into large digita Health and Human Services, Department of / National Institutes of Health 7/01/2010
THE VANDERBILT UNIVERSITY $242,680 Grant Trans-NIH Recovery Act Research Support: This request for an Administrative Supplement to the parent grant (5 R01 AI061721-05) entitled Molecular Basis of iNKT Cell Ontogeny and Function is responsive to NOT-OD-09-056 (NIH Announces the Availability of Recovery Act Funds for Administrative Suppl Health and Human Services, Department of / National Institutes of Health 8/23/2010
UNIVERSITY OF CHICAGO, THE $2,335,143 Grant Trans-NIH Recovery Act Research Support: This proposal addresses Theme 4 (Focusing on global health) of NIH RFA-OD-10-005 by aiming to generate staphylococcal vaccines. The project also addresses Theme 1 (Applying Genomics and Other High Throughput Technologies) through the systematic analysis o Health and Human Services, Department of / National Institutes of Health 9/29/2010
LEICA MICROSYSTEMS INC. $990,000 Contract : TCS STED 2 Color system Confocal Microscope purchase to be used in the Core Imaging laboratory and quoted to Dr. Owen Schwartz. This system will be used to image structures normally too small to be resolved on regular confocal microscope, which are limit Health and Human Services, Department of / National Institutes of Health 9/28/2010
ONEIDA COMMUNICATIONS, INC. $4,350,896 Contract : Installation of cabling for PNRC B35 Phase II cable project Health and Human Services, Department of / National Institutes of Health 6/10/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $1,396,894 Grant Trans-NIH Recovery Act Research Support: The proposed Revision aims to contribute to the elimination of racial, ethnic and socioeconomic disparities in cardiovascular disease (CVD), including hypertension and stroke, the leading cause of death for all Americans, a major contributor to racial dis Health and Human Services, Department of / National Institutes of Health 9/23/2010
NTVI ENTERPRISES, LLC $4,934,137 Contract : Upgrade Building Number 38 Electrical Vault. Health and Human Services, Department of / National Institutes of Health 9/28/2010
UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE $4,255,543 Grant Trans-NIH Recovery Act Research Support: The overall purposes of this project are to 1) optimize conditions for development of functional three dimensional lung tissue from embryonic and/or induced pluripotent stem cells grown in de-cellularized mouse lungs and 2) develop strategies for successf Health and Human Services, Department of / National Institutes of Health 9/17/2010
PURDUE UNIVERSITY $562,164 Grant Trans-NIH Recovery Act Research Support: Dietary intake provides some of the most valuable insights for mounting intervention programs for prevention. With the growing concern about adolescent overweight and obesity, the need to accurately measure diet becomes imperative. Assessment among adol Health and Human Services, Department of / National Institutes of Health 7/12/2010
WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY $221,700 Grant Trans-NIH Recovery Act Research Support: A critical component of the Weill Cornell CTSC (WC/CTSC) is the training of a diverse group of future investigators through our Clinical and Translational Education Program (CTEP). Included in the program , and as part of our initial K30 grant, we develo Health and Human Services, Department of / National Institutes of Health 9/23/2010
UNIVERSITY OF NEVADA, RENO $143,737 Grant Trans-NIH Recovery Act Research Support: Atherosclerosis is a chronic inflammatory disease, characterized by neointimal plaque formation due to endothelial dysfunction, the infiltration by T lymphocytes (T cells) and macrophages, and proliferation and migration of vascular smooth muscle cells (V Health and Human Services, Department of / National Institutes of Health 7/19/2010
IMMIXTECHNOLOGY, INC. $398,008 Contract : Product License Health and Human Services, Department of / National Institutes of Health 8/27/2010
UNIVERSITY OF CALIFORNIA, LOS ANGELES $230,969 Grant Trans-NIH Recovery Act Research Support: This application is in response to NOT-OD-10-033, NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications (RO1, RO3, R15, R21, R21/R33, and R37) for HIV/AIDS-related Research through the NIH Basic Behavioral and Social S Health and Human Services, Department of / National Institutes of Health 9/20/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $2,908,784 Grant Trans-NIH Recovery Act Research Support: This project covers 3 thematic areas: Applying Genomics and Other High Throughput Technologies, Translating Basic Science Discoveries into New and Better Treatments and Reinvigorating the Biomedical Research Community. Somatic cells are highly stable in a Health and Human Services, Department of / National Institutes of Health 9/13/2010
NORTHWESTERN UNIVERSITY $389,024 Grant Trans-NIH Recovery Act Research Support: Preterm birth in nulliparous women: an understudied population at great risk. The ultimate aims of this observational study of nulliparous women are: to identify maternal characteristics (i.e. environmental, genetic, physiologic) that are associated with Health and Human Services, Department of / National Institutes of Health 7/08/2010
UNIVERSITY OF MARYLAND $160,137 Grant Trans-NIH Recovery Act Research Support: Anthrax toxin consists of three proteins secreted by Bacillus anthracis - protective antigen (PA), edema factor (EF) and lethal factor (LF). LF is a Zn2+-dependent metalloprotease that cleaves members of the mitogen-activated protein kinase kinase (MAPKK) Health and Human Services, Department of / National Institutes of Health 9/07/2010
UNIVERSITY OF MARYLAND $497,557 Grant Trans-NIH Recovery Act Research Support: The human body encounters most pathogens through mucosal sites. Two main portals are the lung and gut, where pathogens are encountered through the aerodigestive tract mucosa and oral ingestion. While both of these organs harbor resident immune cells for p Health and Human Services, Department of / National Institutes of Health 9/27/2010
UNIVERSITY OF ILLINOIS $639,651 Grant Trans-NIH Recovery Act Research Support: For over 40 years, the U.S. military has recognized that the toxin SEB (staphylococcal enterotoxin B) poses a serious incapacitating and lethal threat. In the past 15 years, various biochemical and molecular studies have shown that SEB acts as a superanti Health and Human Services, Department of / National Institutes of Health 8/02/2010
YALE UNIVERSITY $53,726 Grant Trans-NIH Recovery Act Research Support: In evaluating human research projects taking place in international settings, U.S. Institutional Review Boards (IRBs) acknowledge their limitations in the understanding of local culture and context. Yet they remain obligated to comply with the 45CFR46 reg Health and Human Services, Department of / National Institutes of Health 9/25/2010
UNIVERSITY OF WASHINGTON $47,296 Grant Trans-NIH Recovery Act Research Support: This proposal requests a Recovery Act Administrative Supplement to NIH grant 1K08AI073739-01A1 Differential Effects of Progesterone and Estrogen on DC Functions and Lupus Autoimmunity. Grant 1K08AI073739-01A1 seeks to determine the mechanisms by which th Health and Human Services, Department of / National Institutes of Health 8/30/2010
BRANDEIS UNIVERSITY $35,000 Grant Trans-NIH Recovery Act Research Support: Essential divalent transition metals such as zinc, copper, and iron play important structural and catalytic roles in over 300 proteins. However, these and other transition metals also pose a potential threat to an organism. Left unchecked these metals can Health and Human Services, Department of / National Institutes of Health 8/27/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $1,013,474 Grant Trans-NIH Recovery Act Research Support: Scavenger receptors (SRs) are important pattern recognition receptors expressed on mononuclear phagocytes, antigen presenting cells and endothelial cells. They recognize a variety of ligands of self and non self origin and function as phagocytic and/or si Health and Human Services, Department of / National Institutes of Health 9/20/2010
SEATTLE CHILDREN'S HOSPITAL $499,998 Grant Trans-NIH Recovery Act Research Support: This grant proposes to significantly advance the current technology for generation of mouse models of human genetic disease. This addresses broad Challenge Area (15) Translational Science, and Specific Challenge Topic 15-OD(ORDR)-101: Pilot projects for p Health and Human Services, Department of / National Institutes of Health 9/27/2010
OSEL, INC. $198,503 Grant Trans-NIH Recovery Act Research Support: PROJECT NARRATIVE Bacterial vaginosis (BV) is the most common infection of the reproductive tract among women of childbearing age globally. Control of BV recurrence has emerged as a global issue of concern, in light of its significant prevalence and patho Health and Human Services, Department of / National Institutes of Health 7/26/2010
PRICEWATERHOUSECOOPERS LLP $1,496,920 Contract : The NIH Office of Management Assessment (OMA) is responsible for developing, implementing, maintaining, and sustaining the NIH Risk Management Program. Part of this effort includes working to adapt the program as the NIH risk environment changes. While t Health and Human Services, Department of / National Institutes of Health 9/14/2010
UNIVERSITY OF UTAH, THE $142,614 Grant Trans-NIH Recovery Act Research Support: The HIV-1 accessory gene vpr encodes a conserved 96-amino acid protein that induces block of the cell cycle at the 62 phase. Expression of Vpr in CD4+ lymphocytes also induces apoptosis. We have identified the ATR kinase as the cellular factor that mediat Health and Human Services, Department of / National Institutes of Health 9/20/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $160,000 Grant Trans-NIH Recovery Act Research Support: Recruitment focus on Fathers- We will re-engage partners lost to follow-up as well as fathers that we were unable to contact for the T1 interview. We will encourage mothers to provide consent for their partners to enroll in the study. We will seek other a Health and Human Services, Department of / National Institutes of Health 8/11/2010
RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA $90,580 Grant Trans-NIH Recovery Act Research Support: Hypothalamic gonadotropin releasing hormone (GnRH), controls production of luteinizing hormone (LH) and follicle stimulating hormone (FSH), LH regulating ovarian hormones and FSH gamete maturation. In normal ovulatory cycles, differential synthesis/secret Health and Human Services, Department of / National Institutes of Health 8/26/2010
PURDUE UNIVERSITY $91,536 Grant Trans-NIH Recovery Act Research Support: : To reduce health disparities, national targets were set in Healthy People 2010 to increase the rates of initiation and duration of breast feeding. Although initiation rates are nearly met, the targets set to sustain breastfeeding are far from being met. Health and Human Services, Department of / National Institutes of Health 9/01/2010
REGENTS OF THE UNIVERSITY OF MINNESOTA $485,779 Grant Trans-NIH Recovery Act Research Support: The goal of this study is to determine whether electrical stimulation of certain brain regions can be used to improve the gait and balance instabilities associated with ParkinsonG??s disease (PD). An animal model of PD will be used to study the effect of Health and Human Services, Department of / National Institutes of Health 9/01/2010
HEBREW REHABILITATION CENTER FOR AGED, INC. $90,000 Grant Trans-NIH Recovery Act Research Support: The award is an American Recovery and Reinvestment (ARRA) administrative supplement for the Determinants, Decision-Making and Outcomes of Antibiotic Use in Advanced Dementia study (R01AG32982). The aims of this study are: Aim 1. To describe the occurrence Health and Human Services, Department of / National Institutes of Health 9/17/2010
UNIVERSITY OF WISCONSIN SYSTEM $392,243 Grant Trans-NIH Recovery Act Research Support: This proposal requests funds for an laser scanning confocal microscope. This system will be housed in the R.M Bock Laboratories at the University of Wisconsin at Madison and be available for members of the three research entities of this building, the Ins Health and Human Services, Department of / National Institutes of Health 7/22/2010
BETH ISRAEL DEACONESS MEDICAL CENTER INC $48,154 Grant Trans-NIH Recovery Act Research Support: Mutations in TRPC6, a nonspecific cation channel, have been found to lead to hereditary forms of focal segmental glomerulosclerosis. This project aims to define the role of TRPC6 in normal and abnormal glomerular function, with the goal of identifying the Health and Human Services, Department of / National Institutes of Health 9/23/2010
THE VANDERBILT UNIVERSITY $118,090 Grant Trans-NIH Recovery Act Research Support: This project will address the role of natriuretic peptide ligand-reeptor signaling in the regulation of early pregnancy events. Defects in the uterus can cause infertility and pregnancy loss in women. This research will provide deeper insight into the mol Health and Human Services, Department of / National Institutes of Health 7/29/2010
WOMEN & INFANTS HOSPITAL OF RHODE ISLAND $3,736,391 Contract : RECOVERY: Normal fetal growth is a critical component to a healthy pregnancy and the long-term health of the child. The purpose of this contract is to recruit 2,400 low risk, normal weight women with an equal number of White, Hispanic, african American Health and Human Services, Department of / National Institutes of Health 9/30/2010
BRIGHAM AND WOMEN'S HOSPITAL, INC., THE $50,000 Grant Trans-NIH Recovery Act Research Support: This proposal describes a 5-year training program for the development of an academic career in Clinical Pathology. The candidate is completing residency training in clinical laboratory medicine at Harvard Medical School, Boston, and now proposes to expand Health and Human Services, Department of / National Institutes of Health 8/09/2010
OSEL, INC. $425,654 Grant Trans-NIH Recovery Act Research Support: Project Narrative Osel, Inc. is developing a live microbicide by employing a human vaginal isolate of hydrogen peroxideproducing Lactobacillus jensenii that has been genetically modified to constitutively secrete high levels of a potent HIV entry inhibito Health and Human Services, Department of / National Institutes of Health 9/29/2010
WIELKOPOLSKIE CENTRUM ONKOLOGII IM MARII SKLODOWSKIEJ CURIE $343,500 Contract : Wielkopolskie Centrum Onkologii has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of breast, colon, stomach, head and neck, and melanoma cases. These Health and Human Services, Department of / National Institutes of Health 7/07/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $99,944 Grant Trans-NIH Recovery Act Research Support: The incidence of Down syndrome (DS) is one in 700 live births, the life expectancy is now >50 years, and the average IQ is approximately 50. Therefore, DS is a significant social and medical issue. Many phenotypic features of DS, including cognitive defic Health and Human Services, Department of / National Institutes of Health 7/07/2010
MICHIGAN STATE UNIVERSITY $160,862 Grant Trans-NIH Recovery Act Research Support: This project funding will continue the progress of an existing National Institutes of Health award by supporting a postdoctoral research associate to assist the researchers in an ongoing study to identify antiretroviral cofactors for APOBEC3G, which poten Health and Human Services, Department of / National Institutes of Health 9/13/2010
MASSACHUSETTS INSTITUTE OF TECHNOLOGY $85,000 Grant Trans-NIH Recovery Act Research Support: This ARRA project is a supplement to ES16313, The Environment as an Experimental Variable to Calibrate Mouse Models of Human Disease. It supported the work of Ms. Ann Wattanawaraporn, a graduate student, who collaborated with Prof. John Groopman of Johns Health and Human Services, Department of / National Institutes of Health 7/01/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $125,116 Grant Trans-NIH Recovery Act Research Support: The aims of this administrative supplement for the research project Pragmatic Skills of Young Males and Females with Fragile X Syndrome were threefold: (1) to increase the value of the parent grant through enrichment of data from parents who are carriers Health and Human Services, Department of / National Institutes of Health 7/07/2010
MICHIGAN STATE UNIVERSITY $50,000 Grant Trans-NIH Recovery Act Research Support: This project funding will extend an existing National Institutes of Health award by supporting the hire of a licensed nurse and a postdoctoral fellow to assist the researchers in two of the aims of the ongoing study: 1. To study and facilitate the antire Health and Human Services, Department of / National Institutes of Health 8/02/2010
UNIVERSITY OF CHICAGO, THE $76,172 Grant Trans-NIH Recovery Act Research Support: My long term goal is to understand the mechanisms that initiate development of the mammalian cerebral cortex and control the formation of the cortical area map, the basic functional organization of the cortex. Findings should be relevant to understanding Health and Human Services, Department of / National Institutes of Health 7/07/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $131,325 Grant Trans-NIH Recovery Act Research Support: Many commonly prescribed anionic drugs (eg. antibiotics, diuretics, ACE inhibitors, NSAIDs) as well as disease-associated metabolites are organic anions that are excreted as a result of transport by the proximal tubule of the kidney. The rate limiting gen Health and Human Services, Department of / National Institutes of Health 7/09/2010
UNIVERSITY OF WASHINGTON $179,400 Grant Trans-NIH Recovery Act Research Support: This proposal is in response to Notice Number (NOT-OD-10-033), 'NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications (R01, R03, R15, R21, R21/R33, and R37) for HIV/AIDS-related Research through the NIH Basic Behaviora Health and Human Services, Department of / National Institutes of Health 8/18/2010
UNIVERSITY OF WISCONSIN SYSTEM $50,000 Grant Trans-NIH Recovery Act Research Support: The purpose of the proposed studies is to understand the HIV-1 frameshift (FS) mechanism and to learn how it can be targeted with small, drug-like molecules. The HIV-1 FS site is a highly conserved genomic RNA structure located between the gag and pol re Health and Human Services, Department of / National Institutes of Health 9/02/2010
LAHEY CLINIC, INC. $33,482 Grant Trans-NIH Recovery Act Research Support: These studies will integrate the expertise of clinicians, basic scientists, and clinical researchers and have potential to identify A20 based therapies useful for the prevention or treatment of liver graft dysfunction, identify and devise treatment strate Health and Human Services, Department of / National Institutes of Health 9/30/2010
UNIVERSITY OF ALABAMA AT BIRMINGHAM $49,998 Grant Trans-NIH Recovery Act Research Support: This administrative supplement award began in year 4 of the parent project (K02 AI076123). The funds will contribute to: (i) the hiring of a new graduate assistant for data management and data analyses, (ii) the retention of a newly hired, full-time rese Health and Human Services, Department of / National Institutes of Health 8/09/2010
RFCUNY - HUNTER COLLEGE $328,397 Grant Trans-NIH Recovery Act Research Support: ARRA - TRANS-NIH RECOVERY ACT RESEARCH SUPPORTARRA G?? Administrative Supplement to parent grant R01-AI030653-20. This administrative supplement was awarded to sustain a research project that is presently in a no-cost extension. The award provides funds Health and Human Services, Department of / National Institutes of Health 7/06/2010
CHILDREN'S HOSPITAL MEDICAL CENTER $413,350 Grant Trans-NIH Recovery Act Research Support: We currently have projects that are ready to begin. These projects will study the genetic composition of children with lupus from the Rheumatology department and Eosinophilic Esophagitis from the Allergy and Immunology departments. The iScan is a cut Health and Human Services, Department of / National Institutes of Health 8/23/2010
THE VANDERBILT UNIVERSITY $40,105 Grant Trans-NIH Recovery Act Research Support: This application is for a Recovery Act Administrative Supplement (NOT-OD-056) to parent grant R01 HD23264, Developmental Outcomes of Pediatric Chronic Abdominal Pain (2007-2012). The parent grant uses a prospective design and experimental methods to ident Health and Human Services, Department of / National Institutes of Health 7/30/2010
UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON $326,294 Grant Trans-NIH Recovery Act Research Support: This component supports a KL2 Scholar to develop special expertise in CER and provides 0.75 protected time, course work, and mentorship while conducting major CER. The candidates are Susan Wootten, M.D., Patricia Evans, M.D., and Claudia Pedroza, M.D. Health and Human Services, Department of / National Institutes of Health 9/23/2010
SCRIPPS RESEARCH INSTITUTE, THE $760,703 Grant Trans-NIH Recovery Act Research Support: The vaccine-induced immune responses that, alone or in combination, will provide optimal protection for a large population of individuals against infection by HIV are still unknown. Nevertheless, many regard the induction of broadly neutralizing antibodie Health and Human Services, Department of / National Institutes of Health 9/30/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $158,258 Grant Trans-NIH Recovery Act Research Support: The epithelial to mesenchymal transition (EMT) is a fundamental developmental process that can be reactivated in epithelial cancers to promote tumor invasion and metastasis. The ESRPs are master regulators of an epithelial splicing program and a comprehen Health and Human Services, Department of / National Institutes of Health 7/02/2010
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK $36,132 Grant Trans-NIH Recovery Act Research Support: Melanin-concentrating hormone (MCH) mediates a variety of neurological functions including appetite and energy expenditure. The discovery of MCH receptors in peripheral tissues such as adipose tissue and pancreatic beta cells broadens the potential impact Health and Human Services, Department of / National Institutes of Health 9/09/2010
MAX MOBILITY, LLC $38,507 Grant Trans-NIH Recovery Act Research Support: Manual wheelchair users are at considerable risk of developing upper limb overuse injuries. One preventative measure is to improve the user's push style. This project will develop the understanding required to teach proper propulsion technique. ABSTRACT M Health and Human Services, Department of / National Institutes of Health 7/10/2010
JOHNS HOPKINS UNIVERSITY, THE $959,827 Grant Trans-NIH Recovery Act Research Support: Poor adherence to medication regimens is associated with worsening of disease, death and increased health care costs in the United States. The few studies conducted in the emergency department (ED) setting suggest that between 7 to 45 percent of patients Health and Human Services, Department of / National Institutes of Health 8/19/2010
JOHNS HOPKINS UNIVERSITY, THE $2,078,635 Grant Trans-NIH Recovery Act Research Support: This application is in response to RFA number RFA-OD-10-005 and addresses thematic area 1: Applying genomics and other high throughput technologies. Retrotransposons are an often-overlooked source of inter-individual genomic variation in mammals. The prim Health and Human Services, Department of / National Institutes of Health 9/27/2010
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $161,089 Grant Trans-NIH Recovery Act Research Support: During the current quarter we acquired components to upgrade our Olympus inverted light microscope for laser scanning capability. The microscope is now capable of constant environment, constant temperature, high resolution imaging and will be of great va Health and Human Services, Department of / National Institutes of Health 8/18/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $188,254 Grant Trans-NIH Recovery Act Research Support: The fact that HIV-specific cytotoxic T-lymphocytes (CTL) responses against certain areas of the virus may be more effective at controlling HIV replication than CTL with other specificities suggests that vaccine should elicit selected CTL responses associa Health and Human Services, Department of / National Institutes of Health 9/27/2010
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $1,212,874 Grant Trans-NIH Recovery Act Research Support: Refinement and enhancement of a web-based risk calculator deployment system .The quality of medical decision making suffers because risk predictions are not tailored to the individual patient. Further, available risk models and tools are not widely used b Health and Human Services, Department of / National Institutes of Health 8/24/2010
WAYNE STATE UNIVERSITY (INC) $228,000 Grant Trans-NIH Recovery Act Research Support: We propose to examine the hypothesis that MKP-1 is involved in the anabolic actions of PTH and PTHrP. With the interim support (R56 award), we plan to generate more preliminary data using multiple in vitro and in vivo approaches of osteoblast cell lines a Health and Human Services, Department of / National Institutes of Health 8/13/2010
TRUSTEES OF DARTMOUTH COLLEGE $54,200 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The dramatic increase in HIV/AIDS, tuberculosis and malaria research that has occurred in Tanzania over the past decade has challenged existing research bioethics resources and infrastructure in Tanzania. Procedure Health and Human Services, Department of / National Institutes of Health 9/24/2010
ILLUMINA, INC. $147,000 Contract : iScan System For: Settara Chandra Health and Human Services, Department of / National Institutes of Health 5/07/2010
BROAD INSTITUTE, INC., THE $24,870,017 Grant Trans-NIH Recovery Act Research Support: We are embarking on contributing to a large catalogue of DNA sequence variation in phenotyped samples and to pioneering the application of this depth and scale of data to the analysis of key cardiovascular phenotypes. We propose to do this by (1) performi Health and Human Services, Department of / National Institutes of Health 9/28/2009
LELAND STANFORD JUNIOR UNIVERSITY, THE $88,800 Grant Trans-NIH Recovery Act Research Support: Current concepts of innate immune responses to bacterial stimuli such as lipopolysaccharides (e.g., the LPS from S. typhimurium used here) are largely based on data from in vitro stimulation of spleen cells taken from unstimulated mice. However, our recen Health and Human Services, Department of / National Institutes of Health 8/23/2010
BECKMAN COULTER, INC. $14,806 Contract : Swing Bucket Tit Rotor Package Health and Human Services, Department of / National Institutes of Health 5/12/2010
WAKE FOREST UNIVERSITY $2,671,616 Contract : The Systolic Blood Pressure Intervention Trial (SPRINT)-Senior ARRA expansion is designed to test the SPRINT intervention in participants who are ? 75 years of age. Approximately 3,250 of the 9,250 SPRINT participants are expected to be age 75 or older. I Health and Human Services, Department of / National Institutes of Health 9/24/2010
CASE WESTERN RESERVE UNIVERSITY $715,438 Contract : We have been awarded the 'RECOVERY-Tissue Source Site (TSS) Networks in Support of The Cancer Genome Atlas (TCGA) Program' contract to provide gliomas to the NCI. Specifically to establish a TSS network capable of delivering clinically annotated biospeci Health and Human Services, Department of / National Institutes of Health 9/24/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $377,200 Grant Trans-NIH Recovery Act Research Support: Gonadotropin releasing hormone (GnRH) neurons originate in or near the olfactory placode and migrate into the forebrain during embryogenesis. Disruption of GnRH neuronal migration or production results in abnormal reproductive function in humans. Axl is a Health and Human Services, Department of / National Institutes of Health 8/11/2010
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK $53,500 Grant Trans-NIH Recovery Act Research Support: Activation of complement (C) with consequent generation of the C5-derived peptides C5a and C5a des Arg is a primary chemotactic stimulus at sites of infection or injury. Excessive C5a- mediated leukocyte recruitment into various tissues is known to be a c Health and Human Services, Department of / National Institutes of Health 7/02/2010
SINGAPORE HEALTH SERVICES PTE LTD $162,500 Contract : Singapore Health Services has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of lymphoma cases. These cases are all primary and untreated. The colle Health and Human Services, Department of / National Institutes of Health 9/27/2010
CASE WESTERN RESERVE UNIVERSITY $111,096 Grant Trans-NIH Recovery Act Research Support: This administrative supplement to 1U10HD63072-01 (Adverse Outcomes In Nulliparous Pregnancies: The Ohio Collaborative) proposes to administer questionaires investigating novel factors associated with adverse pregnancy outcomes and to perform cervical len Health and Human Services, Department of / National Institutes of Health 7/08/2010
UNIVERSITY OF MARYLAND $150,700 Grant Trans-NIH Recovery Act Research Support: The Developmental Origins of Health and Disease (DOHaD) hypothesis argues that early life events (even pre-conception events) influence the risk of adult disease. Pre- and post-natal environmental factors play vital roles in adult disease risk, ranging fr Health and Human Services, Department of / National Institutes of Health 9/02/2010
UNIVERSITY OF MASSACHUSETTS $86,320 Grant Trans-NIH Recovery Act Research Support: The long-term objective of this research is to determine how ovarian steroids trigger luteinizing hormone-releasing hormone (LHRH) and LH surge release, thereby inducing ovulation. In these studies, we will investigate mechanisms through which potoperiod Health and Human Services, Department of / National Institutes of Health 9/02/2010
ALBERT EINSTEIN COLLEGE OF MEDICINE $499,998 Grant Trans-NIH Recovery Act Research Support: This revised application (A2) responds to the CTSA initiative to establish and sustain an academic-community partnership for clinical and translational research/To achieve this goal, we created the Institute for Clinical and Translational Research (ICTR Health and Human Services, Department of / National Institutes of Health 8/26/2010
INSTITUTE FOR SYSTEMS BIOLOGY $836,445 Grant Trans-NIH Recovery Act Research Support: Cancer onset and progression involves disruptions of complex networks of biomolecular interactions in cells, as a result of genomic and epigenomic aberrations. To achieve a deeper understanding of the genetic basis of cancer and to identify novel translat Health and Human Services, Department of / National Institutes of Health 9/21/2010
GEORGETOWN UNIVERSITY (THE) $4,374,674 Grant Trans-NIH Recovery Act Research Support: Specific Aim 1. We will develop an assay for measuring YK-4-279 in biological samples. A method to extract and analyze YK-4-279 in biological samples has been developed by the Chemistry Technical Center (CTC) at Battelle in support of the in vivo toxicolo Health and Human Services, Department of / National Institutes of Health 9/30/2010
UNIVERSITY OF UTAH, THE $364,393 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Preterm birth (PTB) is the major cause of neonatal morbidity and mortality in non-anomalous neonates. Nulliparous women are a particularly important and relatively understudied group at risk for PTB. They account for a Health and Human Services, Department of / National Institutes of Health 7/08/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $28,596 Grant Trans-NIH Recovery Act Research Support: The 1000 Genomes Project aims to achieve a nearly complete catalog of common human genetic variants by generating high-quality sequence data surveying the genomes of >1000 individuals. This catalog will include SNPs, copy number variants, and short insert Health and Human Services, Department of / National Institutes of Health 9/23/2010
JOHNS HOPKINS UNIVERSITY, THE $348,766 Grant Trans-NIH Recovery Act Research Support: The central element in allergic diseases such as asthma, rhinitis and eczema, is the presence of IgE antibody. While there is general acceptance of the central role for IgE in these diseases, there remains only a poor understanding of the quantitative req Health and Human Services, Department of / National Institutes of Health 8/02/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $4,579,758 Grant Trans-NIH Recovery Act Research Support: This is an analysis of a variety of different disease/vaccine models in order to define common and unique characteristics of responder and non-responder individuals to develop new informative tools and assays that should be illuminating both to specific q Health and Human Services, Department of / National Institutes of Health 7/12/2010
UNIVERSITY OF RHODE ISLAND $2,845,473 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The University of Rhode Island (URI), the state's flagship public research university, received $86 million in sponsored program awards in FY 2009. Approximately 80% of this research was federally funded, with approxim Health and Human Services, Department of / National Institutes of Health 3/31/2010
UNIVERSITY OF MARYLAND $97,100 Grant Trans-NIH Recovery Act Research Support: The experiments in this proposal are designed to investigate the basis of changes in cognitive flexibility caused by normal aging. Subsets of elderly humans and rats appear to have difficulty changing behaviors when the likely outcomes of those behaviors Health and Human Services, Department of / National Institutes of Health 9/14/2010
REGENTS OF THE UNIVERSITY OF MINNESOTA $154,331 Grant Trans-NIH Recovery Act Research Support: The discovery of the anti-viral APOBEC3 proteins is regarded as one of the most therapeutically promising breakthroughs in HIV/AIDS molecular virology in recent years. Humans have seven APOBEC3 proteins and at least two, APOBEC3F and APOBEC3G, are known t Health and Human Services, Department of / National Institutes of Health 9/20/2010
FLORIDA STATE UNIVERSITY, THE $100,000 Grant Trans-NIH Recovery Act Research Support: Equipment funds will be used to purchase piece of one chromatography equipment and a bacteria growth shaker to replace our aging equipments to conduct the following work: Ribosome biogenesis is an essential cellular process that must meet the demands of n Health and Human Services, Department of / National Institutes of Health 8/25/2010
THOMAS JEFFERSON UNIVERSITY $574,971 Grant Trans-NIH Recovery Act Research Support: Our preliminary results show that exposure of epithelial cells to tungsten carbide cobalt (WC-Co) nanoparticles produced high levels of reactive oxygen species (ROS). WC-Co nanoparticles induced AKT and ERK1/2 activation, and increased the transcriptional Health and Human Services, Department of / National Institutes of Health 8/30/2010
JOHNS HOPKINS UNIVERSITY, THE $469,986 Grant Trans-NIH Recovery Act Research Support: This S10 Shared Instrumentation Grant application seeks funding in support of confocal live imaging resources for the Johns Hopkin University's Center for Functional Investigation in Zebrafish, also known as FinZ Center. FinZ Center was established i Health and Human Services, Department of / National Institutes of Health 7/08/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $60,045 Grant Trans-NIH Recovery Act Research Support: Gametogenesis in females is controlled by follicle-stimulating hormone (FSH) from the pituitary, which is, in turn, regulated by gonadotropin-releasing hormone (GnRH) from the hypothalamus. GnRH regulates FSH synthesis through induction of the immediate e Health and Human Services, Department of / National Institutes of Health 8/11/2010
SOUTH CAROLINA RESEARCH FOUNDATION $181,250 Grant Trans-NIH Recovery Act Research Support: Promoting Healthy Weight in Pregnancy and Postpartum Among Overweight/Obese Women African American women are more likely than other racial groups to enter pregnancy overweight or obese. Overweight and obese women are more likely to gain excessive weight d Health and Human Services, Department of / National Institutes of Health 9/09/2010
UNIVERSITY OF ROCHESTER $204,070 Grant Trans-NIH Recovery Act Research Support: We propose to develop a general task prompting and reminding system that runs on an ordinary cell phone for persons with cognitive disabilities. The system will use information from a variety of sensors to determine the user's activity and context, so tha Health and Human Services, Department of / National Institutes of Health 9/15/2010
ALLENTOWN INC $221,837 Contract : Manufacture resarch animal caging. Model No. PNCT4U24FER2X. Health and Human Services, Department of / National Institutes of Health 7/01/2010
MOUNT SINAI SCHOOL OF MEDICINE $249,999 Grant Trans-NIH Recovery Act Research Support: Platelet derived growth factors (PDGFs) are required the formation of oligodendrocytes, neural crest, vascular smooth muscle and a variety of cell types of mesenchymal origin, and the deregulation of this pathway has been implicated in disease and in vari Health and Human Services, Department of / National Institutes of Health 8/25/2010
UNIVERSITY OF CALIFORNIA, IRVINE $382,500 Grant Trans-NIH Recovery Act Research Support: Chlamydia is a pathogenic bacterium with a significant impact on public health. In 2006, more than a million chlamydial infections were reported to the CDC making it the most commonly reported infectious disease. The ability of this organism to cause dise Health and Human Services, Department of / National Institutes of Health 9/07/2010
VIRGINIA COMMONWEALTH UNIVERSITY $373,750 Grant Trans-NIH Recovery Act Research Support: The focus of this proposal is to determine the mechanisms regulating expression of ?V?3 integrin, its ligands, fibronectin and vitronectin, and determine how they jointly regulate IGF-I stimulated smooth muscle cell hyperplasia. Smooth muscle hyperplasia Health and Human Services, Department of / National Institutes of Health 8/16/2010
SCRIPPS RESEARCH INSTITUTE, THE $31,500 Grant Trans-NIH Recovery Act Research Support: Cell motility is a basic process that contributes to both normal (e.g. wound healing) and pathological (e.g. metastasis) cell behavior. Underlying the migratory abilities of cells are the dynamics of actin at the leading edge, regulated in response to Rho Health and Human Services, Department of / National Institutes of Health 8/13/2010
UNIVERSITY OF FLORIDA $134,708 Grant Trans-NIH Recovery Act Research Support: We propose the first comprehensive evaluation of the intestinal microbiota in premature infants at risk for necrotizing enterocolitis (NEC). The overall goals respond to objectives of the NIH Funding Opportunity Announcement, which include: 1. gaining a b Health and Human Services, Department of / National Institutes of Health 7/27/2010
ILLUMINA, INC. $449,924 Contract : PhiX Control and Sequencing Primer (100 Lanes) 5 DGE Small RNA Sample Prep Kit (1002698) ChIP-Seq Sample Preparation Kit 4 PE Sample Prep Kit mRNA-Seq 8 sample prep kit Multiplexing Sample Preparation Oliogonucleotide Kit cBot Paired End cluster Generatio Health and Human Services, Department of / National Institutes of Health 9/24/2010
MOUNT SINAI SCHOOL OF MEDICINE $219,823 Grant Trans-NIH Recovery Act Research Support: The complement system, traditionally considered part of the innate immune repertoire has been implicated as a modulator of cell mediated allograft injury. Our group has further shown that alternative pathway complement components C3, factor D and factor B Health and Human Services, Department of / National Institutes of Health 7/12/2010
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $102,379 Grant Trans-NIH Recovery Act Research Support: Abdominal aortic aneurysms (AAAs), characterized by degrading aortic elastin matrix and resultant vessel weakening and rupture, causes 15,000 deaths in the United States anually, primarily amongst seniors, and those suffering from inherited matrix disorde Health and Human Services, Department of / National Institutes of Health 7/29/2010
TRUSTEES OF INDIANA UNIVERSITY $129,650 Grant Trans-NIH Recovery Act Research Support: We are requesting Administrative Supplements funds to our parent grant 5R01GM078501-03 entitled G?CYP2B6 genetic variations and drug interactionsG? to meet increased costs that are within the scope of an approved application, but that were unforeseen or u Health and Human Services, Department of / National Institutes of Health 7/02/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $464,438 Grant Trans-NIH Recovery Act Research Support: The Translational Immunology Center is focused on a comprehensive evaluation of the basis for the chronicity of HCV, a CDC Emerging Pathogen with a remarkable ability to ensure its persistence in the human host. THe tempo and progress of these projects wo Health and Human Services, Department of / National Institutes of Health 9/07/2010
UNIVERSITY OF WASHINGTON $508,750 Grant Trans-NIH Recovery Act Research Support: We propose to build on our key findings with supplemental ARRA funding for projects within the original scope and to ensure success of the grant in four areas:1. Analyze and model the impact of varying CD4 and plasma viral thresholds for ART initiation o Health and Human Services, Department of / National Institutes of Health 7/12/2010
UNIVERSITY OF MARYLAND $567,190 Grant Trans-NIH Recovery Act Research Support: Vaginitis/vaginosis is one of the most common conditions for women to seek medical care. Some 10 million office visits are attributed to vaginitis, which accounts for a health care cost of over $500 million each year. Over 90% of vaginitis can be attribut Health and Human Services, Department of / National Institutes of Health 8/23/2010
WAKE FOREST UNIVERSITY $451,012 Grant Trans-NIH Recovery Act Research Support: The liver has an enormous capacity to regenerate, as demonstrated by the 2/3 partial hepatectomy model in rodents. A stem cell compartment within the liver is activated when mature hepatocytes are unable to perform their role in this process. The overarch Health and Human Services, Department of / National Institutes of Health 9/30/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $243,842 Grant Trans-NIH Recovery Act Research Support: Each site in the network will submit an administrative supplement to fund an additional research coordinator and sonographer to conduct secondary studies approved by the principal investigators. The studies will augment the network's original scientific p Health and Human Services, Department of / National Institutes of Health 7/13/2010
UNIVERSITY OF IOWA, THE $1,458,033 Grant Trans-NIH Recovery Act Research Support: Treatment rates vary dramatically across patients grouped by race, age, and gender. If treatment effects are heterogeneous across patients, though, it is not clear from treatment rate comparisons alone whether treatment rates should be increased or decrea Health and Human Services, Department of / National Institutes of Health 9/24/2010
RUSH UNIVERSITY MEDICAL CENTER $303,391 Grant Trans-NIH Recovery Act Research Support: There is currently much interest in understanding and defining mechanisms that may protect exposed but not HIV infected individuals. On potential mechanism of protection is the generation of antibodies to HIV in the absence of infection. Such antibodies Health and Human Services, Department of / National Institutes of Health 8/02/2010
PERKINELMER HEALTH SCIENCES, INC $29,253 Contract : ARRA::YES::ARRA TAS::75 0883::TAS RECOVERY ACT: SCINTILLATION COUNTER Health and Human Services, Department of / National Institutes of Health 9/20/2010
EMORY UNIVERSITY $116,250 Grant Trans-NIH Recovery Act Research Support: Emory Parkinson's Disease Environmental Research Center (PD-CERC) Supplement 2: New transgenic mouse lines Recent advances by investigators in the PD-CERC highlight the need for the production of two new mouse models to better understand environmental inf Health and Human Services, Department of / National Institutes of Health 7/02/2010
DANA-FARBER CANCER INSTITUTE, INC. $87,417 Grant Trans-NIH Recovery Act Research Support: Improving the health of Americans depends increasingly on valid self-report measures of health. While important information can be obtained from administrative data and health records, measuring physical and emotional health status in the general populat Health and Human Services, Department of / National Institutes of Health 9/27/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $179,721 Grant Trans-NIH Recovery Act Research Support: The U.S. Family Smoking Prevention and Tobacco Control Act (2009) gives the FDA regulatory authority over the marketing and physical design specifications of tobacco products. One important feature of this authority is the capacity to regulate product fea Health and Human Services, Department of / National Institutes of Health 8/30/2010
TRANSCENDENT INTERNATIONAL, LLC $2,725,224 Grant Trans-NIH Recovery Act Research Support: The Department of Health and Human Services mandates that any entity receiving federal funding G?must offer and provide language assistance services, including bilingual staff and interpreter services, at no cost to each patient/customer with limited Engl Health and Human Services, Department of / National Institutes of Health 7/12/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $259,050 Grant Trans-NIH Recovery Act Research Support: Water Wisdom: Developing Local-Global Capacities in Managing Water. The University of North Carolina at Chapel Hill (UNC) proposes a program to engage postdoctoral investigators in interdisciplinary research to address information and decision making rela Health and Human Services, Department of / National Institutes of Health 9/26/2010
QIAGEN INC. $85,155 Contract : Open Market Supplies Health and Human Services, Department of / National Institutes of Health 9/28/2010
JOHNS HOPKINS UNIVERSITY, THE $836,133 Grant Trans-NIH Recovery Act Research Support: The Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) is sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to characterize the natural history of the different phenotypes of nonalcoholic fatty liver Health and Human Services, Department of / National Institutes of Health 9/30/2010
CEDARS-SINAI MEDICAL CENTER $32,403 Contract : Cedars-Sinai Medical Center has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of brain tumor 20 tissues (20cases). These cases are all primary and u Health and Human Services, Department of / National Institutes of Health 7/13/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $386,666 Grant Trans-NIH Recovery Act Research Support: We are assaying whether mouse adenovirus type-1 (MAV-1) uses fiber knob RGD for attachment or entry in fibroblasts, before we move to the resource-intensive primary cells it infects in vivo: monocytes and brain endothelial cells. Suspension cells have bee Health and Human Services, Department of / National Institutes of Health 9/07/2010
SAMSUNG SDS AMERICA, INC. $377,925 Contract : Clinical Decision Support System (RECOVERY-Computational Thinking to Support Clinicians and Biomedical Scientists Medical Advanced Research Projects Initiative, National Library of Medicine, NIH) Health and Human Services, Department of / National Institutes of Health 9/27/2010
NORTH DAKOTA STATE UNIVERSITY $430,500 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The heme-containing enzyme commonly known as chlorite dismutase (Cld) catalyzes the unimolecular decomposition of chlorite ion, ClO2-, as illustrated in Scheme 1. The reaction is thought to proceed via formation of com Health and Human Services, Department of / National Institutes of Health 7/01/2010
UNIVERSITY OF NEW MEXICO $208,604 Grant Trans-NIH Recovery Act Research Support: The New Mexico Alcohol Research Center (NMARC) is a comprehensive, multidisciplinary program focused on fetal alcohol-related behavioral deficits. NMARC's prevailing philosophy is that significant progress towards the dual goals of better diagnoses and in Health and Human Services, Department of / National Institutes of Health 7/09/2010
HEALTH RESEARCH, INC. $335,000 Grant Trans-NIH Recovery Act Research Support: A group of investigators at the Wadsworth Center are requesting funds to purchase a Bruker Avance III 600 MHz NMR spectrometer console. The major users of this instrument include three current and two previous and pending NIH-funded laboratories. The requ Health and Human Services, Department of / National Institutes of Health 7/01/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $100,000 Grant Trans-NIH Recovery Act Research Support: The overall goal of R01A1064285, Modeling Mechanisms of Shigella Pathogenesis in Yeast, is to establish a yeast systems biology approach to determine the roles of bacterial virulence proteins in pathogenesis. This approach is particularly amenable to stud Health and Human Services, Department of / National Institutes of Health 7/19/2010
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $7,717,499 Contract : RECOVERY: National Standard for Normal Fetal Growth Health and Human Services, Department of / National Institutes of Health 9/22/2010
UNIVERSITY OF IOWA, THE $279,765 Grant Trans-NIH Recovery Act Research Support: An essential element of the RFA entitled Institutional Clinical and Translational Science Award, CTSA, is the creation of an academic home that is a department, center, or institute. In response to the RFA, the University of Iowa will create The Universit Health and Human Services, Department of / National Institutes of Health 8/05/2010
UNIVERSITY OF CALIFORNIA, LOS ANGELES $1,000,000 Grant Trans-NIH Recovery Act Research Support: Title: A Community-Academic Policy Partnership for Health Promotion Research Description: Community-based participatory research (CBPR), in which communities are engaged as full partners rather than as mere recipients or subjects of academic research, has Health and Human Services, Department of / National Institutes of Health 9/23/2010
BETH ISRAEL DEACONESS MEDICAL CENTER INC $135,986 Grant Trans-NIH Recovery Act Research Support: Despite tremendous strides in transplantation over the past 60 years, with great advances in short-term graft survival, long-term survival is comparatively poor. This is likely due to the fact that immunosuppressive strategies, though clearly improved ove Health and Human Services, Department of / National Institutes of Health 8/24/2010
FEDERAL PROGRAM INTEGRATORS, LLC $2,938,693 Contract : Provide the NIH's Pet Dept with a state of the art Position Emission Tomography (PET), Computed Tomography (CT) Scanner and associated turn-key design/build install Health and Human Services, Department of / National Institutes of Health 9/15/2010
TEXAS A & M UNIVERSITY $148,653 Grant Trans-NIH Recovery Act Research Support: These funds will be used to hasten the conduct and dissemination of studies that are within the scope of the three broad aims of the parent grant entitled The Impact of Grade Retention. To study the impact of grade retention and to identify social proces Health and Human Services, Department of / National Institutes of Health 8/17/2010
EMORY UNIVERSITY $106,821 Grant Trans-NIH Recovery Act Research Support: Title: Nitrated Fatty Acids, Novel Anti-inflammatory Mediators in Allergic Airway Disease Asthma is a highly prevalent airway disease for which available treatment options are inadequate. Endogenous nitrated fatty acids (NFAs), produced from NO, have rece Health and Human Services, Department of / National Institutes of Health 8/30/2010
APPLIED BIOSYSTEMS, LLC $46,000 Contract : MED & SURGICAL INSTRUMENTS,EQ & SUP Health and Human Services, Department of / National Institutes of Health 9/22/2010
NORTH DAKOTA STATE UNIVERSITY $431,697 Grant Trans-NIH Recovery Act Research Support: The goal of the project is to assess the translational impact of video game training on enhancing older adultsG?? attention skills and to determine its ability to improve daily cognitive activities that allow older adults to maintain independence. The pr Health and Human Services, Department of / National Institutes of Health 9/20/2010
WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY $764,113 Grant Trans-NIH Recovery Act Research Support: Cluster randomized clinical trials (RCTs) and observational studies are each vulnerable to treatment group imbalance at baseline. This problem is seen in designs such as these that do not use patient-level randomization. Imbalance, in turn, compromises tr Health and Human Services, Department of / National Institutes of Health 9/27/2010
EMORY UNIVERSITY $1,171,865 Grant Trans-NIH Recovery Act Research Support: Hospital length of stay (LOS) is a central factor in the increasingly important and complex interplay between quality of healthcare delivery and medical costs. The inpatient environment bolsters the intensity of care, and indeed longer hospital stays have Health and Human Services, Department of / National Institutes of Health 9/21/2010
JOHNS HOPKINS UNIVERSITY, THE $93,741 Grant Trans-NIH Recovery Act Research Support: Human immunodeficiency virus type -1 (HIV-1) infection is the commonest cause of dementia in adults less than 40 years of age. Alcohol is a common drug of abuse in HIV-infected patients that can worsen the decline of frontal lobe function that is associat Health and Human Services, Department of / National Institutes of Health 8/09/2010
UNIVERSITY OF IOWA, THE $98,880 Grant Trans-NIH Recovery Act Research Support: The long-term objectives and specific aims of this proposal are to establish the University of Iowa Department of Urology and Preventive Medicine trials group as a Clinical Evaluation and Treatment Center (CETC) in a multi-institutional research consortiu Health and Human Services, Department of / National Institutes of Health 9/30/2010
UNIVERSITY OF TEXAS AT EL PASO $84,844 Grant Trans-NIH Recovery Act Research Support: Recently we have demonstrated an essential role of the lens epithelium-derived growth factor (LEDGF/p75) in the human immunodeficiency virus type 1 (HIV-1) DNA integration process. T cells lacking this chromatin-bound protein are resistant to HIV-1 infe Health and Human Services, Department of / National Institutes of Health 8/02/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $146,322 Grant Trans-NIH Recovery Act Research Support: The 3D-Structure of the Immunoglobulin Heavy Chain Locus In recent studies it has become clear that the CTCF proteins act as a ?weaver of the genome?. Specifically, the CTCF proteins functions as anchors of loops that organize the chromatin fiber into ro Health and Human Services, Department of / National Institutes of Health 8/09/2010
UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON $95,267 Grant Trans-NIH Recovery Act Research Support: This award is a Recovery Act Administrative Supplement for the G?NIH Pathway to Indepedence Award SchemeG? (K99/R0O), 4R00A1072961-02. The overall scope of the project is the study of pathogenesis of Enterococcus faecium, one of the most difficult bacteri Health and Human Services, Department of / National Institutes of Health 8/02/2010
UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS $297,188 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Multiple sclerosis (MS) is an inflammatory, demyelinating disorder of the central nervous system (CNS) and is responsible for long-term morbidity in over 300,000 people in the United States. Although the precise etiolo Health and Human Services, Department of / National Institutes of Health 8/02/2010
TRUSTEES OF INDIANA UNIVERSITY $473,753 Grant Trans-NIH Recovery Act Research Support: The Specific Aims are: 1) To test the hypothesis that rats will self-medicate with a nonpsychoactive cannabinoid analgesic to attenuate a neuropathic pain state. 2) To test the hypothesis that a nonpsychoactive cannabinoid analgesic will produce minimal d Health and Human Services, Department of / National Institutes of Health 8/25/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $155,530 Grant Trans-NIH Recovery Act Research Support: In our prior work, performed during the initial funding period and now published in two manuscripts in the Journal of Experimental Medicine, we have shown that interactions between HLA class I alleles and immunoregulatory MHC class I receptors expressed o Health and Human Services, Department of / National Institutes of Health 9/27/2010
WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY $163,930 Grant Trans-NIH Recovery Act Research Support: The role of the transcription factor Brachyury (Bra) in notochord formation is well documented and evolutionarily conserved throughout the chordate phylum. However, still little is known about the transcription factors controlled directly or indirectly by Health and Human Services, Department of / National Institutes of Health 7/07/2010
UNIVERSITY OF MASSACHUSETTS $247,634 Grant Trans-NIH Recovery Act Research Support: The parent RO1 grant of this ARRA supplement received a score of 115 (1.3%) in 2007. The goal was to use both cultured rodent primary neurons and Drosophila models to examine molecular mechanisms of the pathogenesis of frontotemporal dementia (FTD). In th Health and Human Services, Department of / National Institutes of Health 9/10/2010
PC MALL GOV, INC. $99,774 Contract : COMPUTER EQUIPMENT - SUN FIRE X4600 SERVER Health and Human Services, Department of / National Institutes of Health 5/26/2010
DREXEL UNIVERSITY $77,040 Grant Trans-NIH Recovery Act Research Support: Concussions, sometimes referred to as mild traumatic brain injuries, are a significant public health issue in this country. Prevalence estimates vary widely, ranging from 300,000 sports related concussions annually (a CDC earlier estimate) to over 2 mill Health and Human Services, Department of / National Institutes of Health 9/13/2010
UNIVERSITY OF WISCONSIN SYSTEM $400,000 Grant Trans-NIH Recovery Act Research Support: The Center for Health Enhancement Systems Studies at the University of Wisconsin - Madison submits this proposal, entitled 'Building a Sustainable National Infrastructure for Research and Dissemination of Improved Behavioral Health Treatment Practices,' i Health and Human Services, Department of / National Institutes of Health 9/30/2010
SUN HEALTH RESEARCH INSTITUTE $56,500 Grant Trans-NIH Recovery Act Research Support: The purpose of this supplement request is to expand the Native American (NA) Outreach Effort historically conducted under the EIT Core of the Arizona ADCC in conjunction with the Clinical Core. This grant application requests five years of renewed support Health and Human Services, Department of / National Institutes of Health 9/14/2010
MASSACHUSETTS INSTITUTE OF TECHNOLOGY $607,548 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (06) Enabling Technologies and specific Challenge Topic, 06-MH-102: Technologies to study neuronal signaling, plasticity, and neurodevelopment. The complex and diverse fu Health and Human Services, Department of / National Institutes of Health 9/03/2010
WHITEHEAD INSTITUTE FOR BIO-MEDICAL RESEARCH $311,563 Grant Trans-NIH Recovery Act Research Support: This supplement was awarded so we could create and preserve jobs, build our scientific infrastructure, and accelerate the pace and expand the objectives within the scope of our Reprogramming grant. To this purpose, we have hired a new postdoc, Dr. Haoyi Health and Human Services, Department of / National Institutes of Health 7/19/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $2,000,000 Grant Trans-NIH Recovery Act Research Support: Administrative Supplement-2/2 A genome-wide association study to detect genetic variation for schizophrenia Clozapine (CLO) is one of the most effective antipsychotics but its use is limited by the risk of agranulocytosis, an uncommon but serious advers Health and Human Services, Department of / National Institutes of Health 5/31/2010
RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA $143,505 Grant Trans-NIH Recovery Act Research Support: It is estimated that 3.2 million African Americans aged 20 years or older have type 2 diabetes. This represents approximately 13% of the AA population and a significant proportion of the more than 20 million Americans believed to be living with diabetes, Health and Human Services, Department of / National Institutes of Health 7/26/2010
BRIGHAM AND WOMEN'S HOSPITAL, INC., THE $44,500 Grant Trans-NIH Recovery Act Research Support: The long term goal of this project is to understand, at the cellular level, the mechanisms by which gastric mucosa protects itself against damage by trauma and systemic sepsis or stress. This proposal focuses on zinc as a signal of oxidative stress that o Health and Human Services, Department of / National Institutes of Health 8/05/2010
DLT SOLUTIONS, LLC $259,989 Contract : Informatica Software License and Maintenance Health and Human Services, Department of / National Institutes of Health 9/14/2010
GEORGIA HEALTH SCIENCES UNIVERSITY RESEARCH INSTITUTE, INC. $104,300 Grant Trans-NIH Recovery Act Research Support: Our long-term goal is to elucidate the roles of a novel protein C53 in regulation of cell cycle progression and DNA damage response, and to explore potential utilization of this novel protein as a novel therapeutic approach. Regulation of cell cycle and c Health and Human Services, Department of / National Institutes of Health 8/23/2010
THE VANDERBILT UNIVERSITY $115,126 Grant Trans-NIH Recovery Act Research Support: This proposal seeks to continue development of the NIDDK Consortial Interconnectivity Network (dkCOIN), an important initiative that will enable the long term storage, tracking and exchange of annotated scientific resource information between NIDDK-funded Health and Human Services, Department of / National Institutes of Health 9/30/2010
CEDARS-SINAI MEDICAL CENTER $97,852 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The Community Child Health Network (CCHN) Phase II research proposes to: (1) advance understanding of the combined biomedical, social, behavioral, and environmental influences on the course of prenatal development, pre Health and Human Services, Department of / National Institutes of Health 9/22/2010
UNIVERSITY OF MONTANA SYSTEM $306,000 Grant Trans-NIH Recovery Act Research Support: Upgrade of current CompuCyte LSC (Laser Scanning Cytometer) to the CompuCyte iCys, Research Imaging Cytometer from CompuCyte Corporation. Since the purchase of our laser scanning cytometer (LSC) in 2000, there have been major advances in technology, both Health and Human Services, Department of / National Institutes of Health 7/08/2010
TRUSTEES OF INDIANA UNIVERSITY $128,701 Grant Trans-NIH Recovery Act Research Support: A consortium of obstetric researchers recently has been brought together, with NICHD support, to investigate the genomic and proteomic basis for adverse pregnancy outcomes in nulliparous women (Preterm Birth in Nulliparous Women: An Understudied Populatio Health and Human Services, Department of / National Institutes of Health 7/08/2010
MAYO CLINIC $347,136 Grant Trans-NIH Recovery Act Research Support: The development and conduct of clinical trials consists of a coordinated set of activities beginning with concept development and continuing through protocol development and activation, data quality control, auditing, and results reporting. The time consu Health and Human Services, Department of / National Institutes of Health 7/02/2010
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. $50,000 Grant Trans-NIH Recovery Act Research Support: The recent research from this laboratory provides direct evidencethat Drosophila is a suitable genetic model for studying molecular, cellular and neural basis of feeding behavioral control and eating disorders. We have shown that Drosophila neuropeptide F Health and Human Services, Department of / National Institutes of Health 3/22/2010
WAKE FOREST UNIVERSITY $2,392,562 Contract : The Systolic Blood Pressure Intervention Trial (SPRINT)-Senior ARRA expansion is designed to test the SPRINT intervention in participants who are ? 75 years of age. Approximately 3,250 of the 9,250 SPRINT participants are expected to be age 75 or older. I Health and Human Services, Department of / National Institutes of Health 9/24/2010
THE VANDERBILT UNIVERSITY $51,307 Grant Trans-NIH Recovery Act Research Support: The students will participate in research and training in a dynamic lab environment, performing molecular biology experiments aimed at exploring the molecular and cellular basis for neutralization of HIV. A subset of HIV-specific antibodies can neutralize Health and Human Services, Department of / National Institutes of Health 9/27/2009
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $241,500 Grant Trans-NIH Recovery Act Research Support: The purpose of the grant is to understand environmental memory in the monkey, a phenomenon whereby neurons in the lateral intraparietal area of the monkey respond to saccades which bring the spatial location of a stimulus which appeared on a previous tria Health and Human Services, Department of / National Institutes of Health 8/31/2010
CLEMSON UNIVERSITY $35,371 Grant Trans-NIH Recovery Act Research Support: Human DNA sequence differs among individuals and the most common variations are known as single nucleotide polymorphisms, or SNPs. Studies have shown that non-synonymous coding SNPs (nsSNPs - SNPs occurring in protein coding regions which lead to amino ac Health and Human Services, Department of / National Institutes of Health 6/28/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $48,886 Grant Trans-NIH Recovery Act Research Support: Development of Eppin as a Male Contraceptive The long-term goals of this research project are to develop eppin as a male contraceptive target. We have been studying the interaction of eppin with semenogelin on the human sperm surface, particularly with re Health and Human Services, Department of / National Institutes of Health 7/01/2010
SOUTHERN ILLINOIS UNIVERSITY $363,750 Grant Trans-NIH Recovery Act Research Support: Ovulation is a complex and intriguing biological process that is essential for mammalian reproduction. The actions of granulosa cells in the ovary are central to successful ovulation. Initially the follicle consists of a single layer of granulosa cells Health and Human Services, Department of / National Institutes of Health 7/07/2010
WASHINGTON UNIVERSITY, THE $43,972 Grant Trans-NIH Recovery Act Research Support: Lower Urinary Tract Symptoms(LUTS) due to benign prostatic hyperplasia (BPH) are one ofthe most common disorders ofthe aging male. Over the last decade significant advances have been made in characterizing this abnormality and treating it with medical the Health and Human Services, Department of / National Institutes of Health 9/30/2010
JOHNS HOPKINS UNIVERSITY, THE $632,421 Grant Trans-NIH Recovery Act Research Support: WE are isolating and characterizing human mobile element polymorphisms, specifically L1s and Alus. These polymorphisms are called RIPs or retrotransposon insertion polymorphisms. WE plan to produce a microarray that is specific for the detection of these Health and Human Services, Department of / National Institutes of Health 8/10/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $171,423 Grant Trans-NIH Recovery Act Research Support: The goal of the proposed research is to understand at a molecular level, how chemokines and their receptors control cellular migration and activation. These proteins are part of a surveillance system that protects the host from pathogens, abnormal cell gr Health and Human Services, Department of / National Institutes of Health 7/06/2010
CHILDREN'S HOSPITAL MEDICAL CENTER $57,690 Grant Trans-NIH Recovery Act Research Support: The purpose of this Administrative Supplement application for the parent grant R01DK054915-06A1: G?Behavioral and Nutrition Treatment to Help CF Preschoolers GrowG? is to enhance the activity of this multi-center clinical trial by increasing enrollment, i Health and Human Services, Department of / National Institutes of Health 9/30/2010
SCHEPENS EYE RESEARCH INSTITUTE, INC., THE $266,000 Grant Trans-NIH Recovery Act Research Support: About ten million Americans, predominantly women, suffer from dry eye disease, arising from a variety of causes including aging, refractive surgery, menopause, autoimmune disease (Sjogren's syndrome), and trauma. Although the cause of each of these condi Health and Human Services, Department of / National Institutes of Health 8/31/2010
UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC. $958,664 Grant Trans-NIH Recovery Act Research Support: In terms of health, Wyandotte County ranks 105th out of the 105 counties in the state of Kansas. Wyandotte County is a G??majority minorityG?? county with high rates of poverty, unemployment, poor access to healthcare and excessive morbidity and mortality Health and Human Services, Department of / National Institutes of Health 8/19/2010
VYBION, INC. $200,000 Grant Trans-NIH Recovery Act Research Support: This project is for developing a new process for the rapid isolation of high-affinity human antibodies from large synthetic libraries. Health and Human Services, Department of / National Institutes of Health 1/29/2010
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $400,002 Grant Trans-NIH Recovery Act Research Support: The parent study for this ancillary proposal, the Targeting INflammation using SALsalate in Type 2 Diabetes (TINSAL) trial, found that a high dose salicylate, salsalate, improved glycemic control in patients with T2D. These results support the concept th Health and Human Services, Department of / National Institutes of Health 9/30/2010
THE JACKSON LABORATORY $217,311 Grant Trans-NIH Recovery Act Research Support: Alstrom Syndrome (AS) is a rare recessive disorder characterized by progressive neurosensory retinal and aural degeneration, obesity, Type II diabetes and death by the second through fourth decade of life. Frequently encountered complications of the disea Health and Human Services, Department of / National Institutes of Health 7/27/2010
BAYLOR COLLEGE OF MEDICINE $1,950,000 Grant Trans-NIH Recovery Act Research Support: This project addresses the G?Applying Genomics and Other High Throughput TechnologiesG? thematic area. HIV-associated nephropathy (HIVAN) is a unique disease that results from the interplay of environmental factors (HIV), host responses to the virus, and Health and Human Services, Department of / National Institutes of Health 9/29/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $730,861 Grant Trans-NIH Recovery Act Research Support: Description: This supplement requested funds to renovate a building and expand and consolidate the technologies of five existing research cores facilities at UNC-Chapel Hill focused on genome analysis. These cores are currently in separate locations aroun Health and Human Services, Department of / National Institutes of Health 8/05/2010
RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA $50,803 Grant Trans-NIH Recovery Act Research Support: The supplement requests support to examine the light and ultrastructural localization of TSKS during both mouse and human spermatogenesis. As part of these studies co-localizations of TSKS with markers of centrioles and chromatoid bodies would be examined Health and Human Services, Department of / National Institutes of Health 7/21/2010
UNIVERSITY OF CALIFORNIA, SANTA CRUZ $22,124 Grant Trans-NIH Recovery Act Research Support: UCSC ACCESS PROPOSAL ABSTRACT Baccalaureate Bridge to the Biomedical Sciences (ACCESS) R25-GM051765 The University of California at Santa Cruz (UCSC) proposes to continue our training grant (which we have titled 'Baccalaureate Bridge to the Biomedical Sci Health and Human Services, Department of / National Institutes of Health 7/09/2010
BAYLOR COLLEGE OF MEDICINE $11,958,994 Contract : The Human Genome Sequencing Center (HGSC) at Baylor College of Medicine is responding to this RFP to produce up to 31.5 terabases (Tb) of DNA sequence, comprising at least 400 and as many as 1000 cases, in 18 months. This will be followed by 3 optional on Health and Human Services, Department of / National Institutes of Health 9/24/2010
WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY $67,769 Grant Trans-NIH Recovery Act Research Support: Mammalian renal development is dependent on the ureteric bud. Its proximal tip induces nephron formation in the developing kidney and undergoes branching morphogenesis forming the intra-renal collecting system whereas its distal or trunk domain differenti Health and Human Services, Department of / National Institutes of Health 9/30/2010
TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER $307,630 Grant Trans-NIH Recovery Act Research Support: DNA vaccines have shown great promise in eliciting both humoral and cellular immune responses in a variety of rodent and non-human primate models. We are proposing to develop a DNA vaccine against schistosome infection which affects over 200 million peopl Health and Human Services, Department of / National Institutes of Health 8/02/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $80,113 Grant Trans-NIH Recovery Act Research Support: The function of millions of proteins remains unknown, and automated protein function prediction systems have a poor record of performance. We will test hypotheses about protein functional sites by validating high-throughput predictions derived from comput Health and Human Services, Department of / National Institutes of Health 9/23/2010
OHIO STATE UNIVERSITY, THE $469,498 Grant Trans-NIH Recovery Act Research Support: It is widely acknowledged there is a critical need for a well trained workforce to conduct comparative effectiveness research (CER) studies in order to improve patient and provider decision making and to formulate more effective health care policy. The aw Health and Human Services, Department of / National Institutes of Health 7/29/2010
CALIFORNIA INSTITUTE OF TECHNOLOGY $194,400 Grant Trans-NIH Recovery Act Research Support: We request an administrative supplement to our ongoing project aimed at elucidating the genetic, cellular, and molecular basis of a checkpoint defect found in progenitor T cells in autoimmune diabetes-prone NOD mice. We have made major progress in sever Health and Human Services, Department of / National Institutes of Health 9/13/2010
FERRIS STATE UNIVERSITY (INC) $347,997 Grant Trans-NIH Recovery Act Research Support: Melanoma is the most dealy form of human skin cancer. It is estimated that one American dies from melanoma every hour. Melanoma is a highly curable disease when detected at early stages. Determining the etiology of melanoma and the early mechanisms inv Health and Human Services, Department of / National Institutes of Health 7/02/2010
WASHINGTON UNIVERSITY, THE $238,262 Grant Trans-NIH Recovery Act Research Support: The prevalence of childhood overweight (CO) has tripled in recent decades and there is growing recognition of environmental factors related to the rapid increase of this significant public health problem. Socio-ecological models provide a strong theoretic Health and Human Services, Department of / National Institutes of Health 9/24/2010
TRUSTEES OF BOSTON UNIVERSITY $384,050 Grant Trans-NIH Recovery Act Research Support: Epidemiological studies have found less skin cancer in people who have high levels of constitutive pigment and/or tan well. However, we have incomplete understanding of other factors involved in the development of skin cancer, such as capacity to repair p Health and Human Services, Department of / National Institutes of Health 9/27/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $50,000 Grant Trans-NIH Recovery Act Research Support: Use of an administrative supplement to support 2 additional research nurses to enroll study subjects in ongoing work exploring neighborhood level characteristics influencing patterns of pneumococcal carriage in children Health and Human Services, Department of / National Institutes of Health 9/07/2010
UNIVERSITY OF IOWA, THE $203,400 Grant Trans-NIH Recovery Act Research Support: The proposal is a response to Notice Number (NOT-OD-10-032) and Notice Title: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications (R01, R03, R15, R21, R21/R33, and R37) through the NIH Basic Behavioral and Social Sci Health and Human Services, Department of / National Institutes of Health 9/25/2010
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $400,000 Grant Trans-NIH Recovery Act Research Support: Investigators at the University of California, San Diego propose their continued inclusion as a Clinical Center within the 'Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)'. NASH is the most prevalent liver disease in children and one of Health and Human Services, Department of / National Institutes of Health 9/30/2010
TRANSCENDENT INTERNATIONAL, LLC $227,800 Grant Trans-NIH Recovery Act Research Support: Complementary and alternative medicine (CAM) has a significant and growing presence in the United States. By one estimate, Americans make 629 million visits to CAM practitioners annually, as compared to only 386 million made to primary care physicians (Ei Health and Human Services, Department of / National Institutes of Health 9/22/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $458,000 Grant Trans-NIH Recovery Act Research Support: This Administrative Supplement proposes to consolidate in new space the existing resources of two complementary University of Michigan core facilities into one more productive, resilient, responsive, and cost-effective animal phenotyping core. A new senio Health and Human Services, Department of / National Institutes of Health 9/14/2010
BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE, INC. $318,013 Grant Trans-NIH Recovery Act Research Support: ARRA award: Regulation of Bacteroides fragilis multidrug efflux pumps Rising antimicrobial resistance costs 5-30 billion dollars and 90,000 lives in the US alone. Multidrug efflux pumps are largely responsible for this resistance. Bacteroides fragilis Health and Human Services, Department of / National Institutes of Health 7/06/2010
EMORY UNIVERSITY $124,269 Grant Trans-NIH Recovery Act Research Support: PepT1 is mainly expressed in brush-border membranes of enterocytes in the small intestine. PepT1 has a differential pattern of expression in the small intestine. Along the vertical axis, PepT1 is most abundant at the villous tip, with expression decreasin Health and Human Services, Department of / National Institutes of Health 7/19/2010
RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA $25,000 Grant Trans-NIH Recovery Act Research Support: This proposal is a request for an Administrative Supplement for a multi-PI grant, (1 R01 GM08457-01A1) entitled Molecular Mechanisms of RhoA-mediated Ca2+ Sensitization in Vascular Smooth Muscle; the corresponding proposal received a priority score of 110 Health and Human Services, Department of / National Institutes of Health 7/16/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $2,271,441 Grant Trans-NIH Recovery Act Research Support: Our application belongs to the theme, 'Translating Basic Science Discoveries into New and Better Treatments'. The goal of the project is to develop the first selective adenosine monophosphate deaminase- 2 (AMPD2) inhibitor, which we believe will offer an Health and Human Services, Department of / National Institutes of Health 9/30/2010
JAMES' ELECTRICAL CONTROL, INC. $638,141 Contract : CIT DNST DIV Network Systems & Telecommuncations - Bldg 3 Health and Human Services, Department of / National Institutes of Health 6/07/2010
UNIVERSITY OF CHICAGO, THE $428,066 Grant Trans-NIH Recovery Act Research Support: Innate immunity Toll-like receptors (TLR) have a crucial role in the detection of microbial infection. Specificity for conserved pathogen-associated molecular patterns (PAMPs) allows TLR proteins to detect the presence of pathogens and to induce the acti Health and Human Services, Department of / National Institutes of Health 7/06/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $622,891 Grant Trans-NIH Recovery Act Research Support: Cancer Center Core Support Grant - ARRA Clinical research at the UNC Lineberger Comprehensive Cancer Center has undergone impressive growth over the last five to ten years. At over 800 per year, accrual to therapeutic clinical trials is almost twice what Health and Human Services, Department of / National Institutes of Health 9/02/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $301,251 Contract : A full-text search engine is critical to increasing the reuse value of narrative documents stored in electronic health records (EHR). A prominent barrier preventing the effective use of such systems originates from usersG?? lack of search expertise and/or Health and Human Services, Department of / National Institutes of Health 9/21/2010
SPECTRASILK, INC. $200,000 Grant Trans-NIH Recovery Act Research Support: In this grant, we seek to accelerate transitions to clinical trials with a new small diameter silk graft for blood vessels. We will focus on control of blood-silk biomaterial interactions by using a multifunctional approach for spatial regulation of mate Health and Human Services, Department of / National Institutes of Health 9/20/2010
TRUSTEES OF DARTMOUTH COLLEGE $652,431 Grant Trans-NIH Recovery Act Research Support: The recent passage of the Paul Wellstone and Pete Domenici Mental Health Parity and Addiction Equity Act of 2008, which requires private health plans to provide equal coverage of behavioral and medical/surgical services, also known as parity, represents a Health and Human Services, Department of / National Institutes of Health 8/30/2010
SOCIAL & SCIENTIFIC SYSTEMS, INC. $1,999,917 Contract : Increasing Adoption of Early Intervention to Prevent Diabetes After Gestational DM Health and Human Services, Department of / National Institutes of Health 8/18/2010
MILLIPORE CORPORATION $94,577 Contract : Open Market Supplies Health and Human Services, Department of / National Institutes of Health 9/20/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $53,334 Grant Trans-NIH Recovery Act Research Support: Educational Attainment of Rural Youth - ARRA Funding In this research, we are investigating (a) the secondary and postsecondary educational attainment of rural youth; and (b) the role of curricular and extracurricular experiences in the educational attai Health and Human Services, Department of / National Institutes of Health 9/01/2010
OKLAHOMA STATE UNIVERSITY $349,175 Grant Trans-NIH Recovery Act Research Support: The long-term goal of this research program is to understand the neurobiology of monogamy and the social behaviors that comprise this unique mating system. The proposed studies will examine how causal manipulations of a neuropeptide receptor that regulate Health and Human Services, Department of / National Institutes of Health 7/14/2010
UNIVERSITY OF WISCONSIN SYSTEM $255,612 Grant Trans-NIH Recovery Act Research Support: The main project will test the causal effects of social capital on levels and inequalities of children's social and cognitive development during the early elementary years. Social capital here refers to trust and shared expectations embedded in social net Health and Human Services, Department of / National Institutes of Health 8/18/2010
UNIVERSITY OF PUERTO RICO-MEDICAL SCIENCES CAMPUS $1,400,000 Grant Trans-NIH Recovery Act Research Support: This application provides the opportunity to fill the knowledge gap of Comparative Effectiveness Research (CER) for mental health care for Latinos by comparing two public health approaches. One is offered by telephone and one face-to face, consisting of a Health and Human Services, Department of / National Institutes of Health 9/18/2010
UNIVERSITY OF IOWA, THE $104,674 Grant Trans-NIH Recovery Act Research Support: Extending from the surface of nearly all of the cells in our body is a primary cilium, which is thought to function as an antenna monitoring environmental conditions and to be crucial for the maintenance of normal cell behavior. Primary cilia have attract Health and Human Services, Department of / National Institutes of Health 8/30/2010
ENVIRONMENT AND HEALTH GROUP, INC. $126,581 Grant Trans-NIH Recovery Act Research Support: Abstract: HIV infection is on the rise among older women in the U.S. There is an urgent need for culturally-sensitive, gender- specific, and age-appropriate HIV prevention interventions for older women, particularly minority older women who are most at-ri Health and Human Services, Department of / National Institutes of Health 9/21/2010
HOUSE RESEARCH INSTITUTE $467,588 Grant Trans-NIH Recovery Act Research Support: The research proposed under the R56 grant was to develop specific behavioral and electrophysiological tasks for measuring speech pattern contrast perception in children 1.5 to 3 years of age. IRB approval was received on July 7, 2010. Health and Human Services, Department of / National Institutes of Health 7/20/2010
NORTHWESTERN UNIVERSITY $1,999,858 Grant Trans-NIH Recovery Act Research Support: The historical approaches to training biomedical scientists have been very successful at creating a talented, creative, community of scientists, but have failed to produce meaningful improvement in the participation of individuals from underrepresented ra Health and Human Services, Department of / National Institutes of Health 9/30/2010
MEDICAL UNIVERSITY OF SOUTH CAROLINA $2,414,063 Contract : The objective of this project is to study fetal growth patterns in pregnant women of various race/ethnic backgrounds in a logitudinal study and to examine factors that affect health pregnancy, fetal growth and perinatal outcomes. The primary goals of the Health and Human Services, Department of / National Institutes of Health 9/24/2010
UNIVERSITY OF PITTSBURGH THE $158,035 Grant Trans-NIH Recovery Act Research Support: Specific Aim 1: Provide advanced training in CER methods through a new program offered at the University of Pittsburgh. The Research Education and Career Development Core of the CTSI and ICRE currently support extensive educational programs in the basic m Health and Human Services, Department of / National Institutes of Health 9/23/2010
EMORY UNIVERSITY $98,678 Grant Trans-NIH Recovery Act Research Support: HISTONE LYSINE METHYLATION: STRUCTURES AND FUNCTIO The new equipment will accelerate progress in the funded project G?? 2R01GM068680-06. The project focuses on epigenetic regulation, a newly appreciated and fundamentally important set of gene control mech Health and Human Services, Department of / National Institutes of Health 8/30/2010
UNIVERSITY OF WASHINGTON $458,550 Grant Trans-NIH Recovery Act Research Support: Electrical signaling is a nearly ubiquitous property of cells ranging from bacteria to vertebrate neurons. Cellular regulation in nerve, muscle, endocrine, exocrine, epithelial, and lymphatic cells depends on electrical signaling mediated by ion channels Health and Human Services, Department of / National Institutes of Health 7/08/2010
THE VANDERBILT UNIVERSITY $38,750 Grant Trans-NIH Recovery Act Research Support: CpG islands, clusters of CpG dinucleotides in GC-rich regions, are often located in the promoter regions and are considered gene markers. Experiments have shown that methylation of promoter CpG islands plays an important role in gene silencing, carcinogen Health and Human Services, Department of / National Institutes of Health 8/24/2010
NEW YORK UNIVERSITY (INC) $71,232 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Immobility mediated by volatile anesthetics (VAs) appears to result largely from depression of excitatory neurotransmission at the spinal cord level. Neurons transform electrical and chemical stimuli into meaningful ph Health and Human Services, Department of / National Institutes of Health 6/11/2010
OREGON STATE UNIVERSITY $309,069 Grant Trans-NIH Recovery Act Research Support: Normal mammalian reproduction depends on pulsatile secretion of gonadotropin-releasing hormone (GnRH) from the hypothalamus, and ovulation in females requires a robust surge of GnRH. While well known, it is unclear what cellular and molecular mechanisms u Health and Human Services, Department of / National Institutes of Health 9/20/2010
MORGAN STATE UNIVERSITY (INC) $90,058 Grant Trans-NIH Recovery Act Research Support: The program is focused on increasing the number of well-prepared and highly qualified under-represented minority students who can successfully compete for positions in graduate programs leading to the PhD degree in the behavioral or biomedical sciences. Health and Human Services, Department of / National Institutes of Health 7/01/2010
BRIGHAM AND WOMEN'S HOSPITAL, INC., THE $1,331,793 Grant Trans-NIH Recovery Act Research Support: Data on the comparative effectiveness of medications are limited because few head-to-head trials are available and most of them do not represent the general population or real-world practice. Comparative effectiveness research using non-randomized healthc Health and Human Services, Department of / National Institutes of Health 9/20/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $17,159 Grant Trans-NIH Recovery Act Research Support: This supplement provided a summer research opportunity for a high school science instructor. The instructor previously trained with the PI as a post-doctoral fellow until 1995. The instructor was identified as a candidate with prior experience and knowl Health and Human Services, Department of / National Institutes of Health 2/17/2010
UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE $859,726 Grant Trans-NIH Recovery Act Research Support: This Request is the Vermont portion of a regional effort from the northeast IDeA states (VT, NH, ME, RI and DE) to provide the first fiber-optic backbone through northern New England that connects higher-education and biomedical research institutions for Health and Human Services, Department of / National Institutes of Health 8/19/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $499,170 Grant Trans-NIH Recovery Act Research Support: The Southeast Regional Center of Excellence for Emerging Infections and Biodefense (SERCEB) is an NIH/NIAID-funded consortium of institutions across the southeast established in 2003. SERCEB?s mission is to assist the nation in developing and deploying ef Health and Human Services, Department of / National Institutes of Health 7/26/2010
LOUISIANA STATE UNIVERSITY SYSTEM $28,802 Grant Trans-NIH Recovery Act Research Support: We propose to hire one half-time coordinator who has recently completed a Bachelors of Science degree to promote increased enrollment. He/she will coordinate activities of additional study participants and assist with the analysis of the new biomarker of Health and Human Services, Department of / National Institutes of Health 9/29/2009
TRUSTEES OF PRINCETON UNIVERSITY, THE $118,161 Grant Trans-NIH Recovery Act Research Support: The long-term goal of this research is to explore the molecular mechanisms that bacteria use for cell-cell communication. Here we propose an integrated structural, chemical, and biological study of recently identified quorum sensing circuits in two relate Health and Human Services, Department of / National Institutes of Health 8/11/2010
UNIVERSITY OF PITTSBURGH THE $380,715 Contract : RECOVERY-Computational Thinking to Support Clinicians and Biomedical Scientists Health and Human Services, Department of / National Institutes of Health 9/07/2010
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION $153,946 Grant Trans-NIH Recovery Act Research Support: The goal of the administrative supplement project is to determine how the catalytic activity of bacterial ribonuclease III is regulated by YmdB protein. RNase III is a double-stranded(ds) specific phosphodiesterase that is highly conserved in bacteria, a Health and Human Services, Department of / National Institutes of Health 7/09/2010
GENERAL ELECTRIC COMPANY $862,699 Contract : Enhancing ITK for Research, Education, and Clinical Interoperability. Health and Human Services, Department of / National Institutes of Health 6/21/2010
UNIVERSITY OF MARYLAND $300,000 Grant Trans-NIH Recovery Act Research Support: The rapid rise in antibiotic resistance in the past two decades increases the need for alternative therapeutic strategies. A current approach to developing new antibiotics is to target non-essential functions that reduce virulence of infecting organisms b Health and Human Services, Department of / National Institutes of Health 8/30/2010
UNIVERSITY OF CALIFORNIA, LOS ANGELES $120,151 Grant Trans-NIH Recovery Act Research Support: The goal of experiments funded through this administrative supplement was to test whether a functional impairment in GABA-A receptor signaling exists in a mouse model of fragile X syndrome, the so-called Fmr1 knockout (KO) mice. Specifically, we proposed Health and Human Services, Department of / National Institutes of Health 7/07/2010
RESEARCH SOLUTIONS, INC $41,965 Contract : Special Swine Cages were designed and fabricated to allow operators in a BSL 3 facility to assemble and disassemble while in full protective gear and allow the cages to be taken to the cage wash area. Health and Human Services, Department of / National Institutes of Health 6/09/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $431,995 Grant Trans-NIH Recovery Act Research Support: The overall objective of this proposal is the strengthening of interdisciplinary research capacity in Ghana to address global health challenges faced by to low- and middle-income countries (LMICs). This focus reflects the situational analysis of the regio Health and Human Services, Department of / National Institutes of Health 9/27/2010
UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS $67,320 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The primary objective of this study is to evaluate the effectiveness of traditional total contact casts (TCC), removable cast walkers (RCW) and a modification of a RCW, termed the instant total contact cast (ITCC). TCC Health and Human Services, Department of / National Institutes of Health 9/30/2010
EMORY UNIVERSITY $54,170 Grant Trans-NIH Recovery Act Research Support: Ethically-engaged research requires a commitment to universal ethical norms, such as those expressed in the Declaration of Helsinki and the Belmont Report, tempered by a recognition that their implementation and the relative weight given to competing ethi Health and Human Services, Department of / National Institutes of Health 9/25/2010
THE MIRIAM HOSPITAL $130,886 Grant Trans-NIH Recovery Act Research Support: The overall goal of this pilot project is to determine whether recent advances in proteonomics can be applied to HIV-1 transmission as evaluated among persons exposed to HIV who remain uninfected as compared to HIV infected individuals. As the HIV/AIDS e Health and Human Services, Department of / National Institutes of Health 8/30/2010
RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA $338,804 Grant Trans-NIH Recovery Act Research Support: This is an application for supplemental funding to support an expanded analysis of influenza-host cell interactions emanating from studies initiated in the Project 1 of the Cooperative Agreement U-19 AI-83024. The proposed analysis will examine the intera Health and Human Services, Department of / National Institutes of Health 7/06/2010
MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC. $4,780,547 Grant Trans-NIH Recovery Act Research Support: This project addresses one of the leading public health issues in the US - the spread of antibiotic resistant Staphylococcus aureus. S. aureus and especially methicillin resistant (MRSA) strains have emerged as leading causes of life-threatening infection Health and Human Services, Department of / National Institutes of Health 8/11/2010
OHIO STATE UNIVERSITY, THE $364,409 Grant Trans-NIH Recovery Act Research Support: Our primary objective is to extend the NLSY79 young adult data collection for youth age 21 and over through the 2008 and 2010 data collection rounds. These youth represent the oldest children born to NLSY79 female respondents. The ongoing grant has provid Health and Human Services, Department of / National Institutes of Health 8/01/2010
CHILDREN'S HOSPITAL CORPORATION, THE $3,876,697 Grant Trans-NIH Recovery Act Research Support: Fanconi anemia (FA) is a rare recessive syndrome characterized by bone marrow failure, congenital anomalies and a predisposition to malignancy. FA cells have a defect in DNA repair that leads to increased spontaneous chromosomal breakage. This feature inc Health and Human Services, Department of / National Institutes of Health 9/21/2010
UNIVERSITY OF CALIFORNIA, DAVIS $286,510 Grant Trans-NIH Recovery Act Research Support: The instrument requested is a Leica TCS LSI zoom confocal microscope system. We are requesting the current configuration because it has the greatest flexibility in capability and can capture images from live tissues and cells as well as image very large f Health and Human Services, Department of / National Institutes of Health 7/01/2010
DANA-FARBER CANCER INSTITUTE, INC. $4,207,530 Grant Trans-NIH Recovery Act Research Support: This proposal is closely aligned with the Research Theme: 'Translating Basic Science Discoveries into New and Better Treatments'. The USA is in the midst of an epidemic of obesity that is causing a great deal of mortality and morbidity due to its associat Health and Human Services, Department of / National Institutes of Health 9/30/2010
JOHNS HOPKINS UNIVERSITY, THE $2,524,394 Grant Trans-NIH Recovery Act Research Support: High-throughput screen for FDA approved drugs that amplify Beta-cell mass in vivo The aim of the project proposed here is to identify drugs that will be therapeutic in the treatment of Diabetes. Type I (or Juvenile) Diabetes is caused by a chronic loss of Health and Human Services, Department of / National Institutes of Health 9/30/2010
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $276,632 Grant Trans-NIH Recovery Act Research Support: The goal of this supplemental award is to establish the program in CER-STAT, or Comparative Effectiveness Research: Summer Training in Applications and Techniques. By providing rigorous training and mentoring opportunities that focus on CER, we can furnis Health and Human Services, Department of / National Institutes of Health 7/08/2010
TRUSTEES OF BOSTON UNIVERSITY $31,427 Grant Trans-NIH Recovery Act Research Support: In the parent proposal specific aim 2 (below), we proposed to process the tooth fragments, manipulating the scaffolds, seeding the stem cells and insertion of the scaffolds/cells into the tooth canals. These procedures need visual aid with a dissecting mi Health and Human Services, Department of / National Institutes of Health 9/09/2010
UNIVERSITY OF CALIFORNIA, DAVIS $73,398 Grant Trans-NIH Recovery Act Research Support: The general goal of this project is to advance understanding of the principles and molecular mechanism of proton pumping in Cytochrome c oxidase (CcO) - the terminal enzyme of the respiratory electron transport chain - by using computer simulations. The c Health and Human Services, Department of / National Institutes of Health 7/23/2010
CHILDRENS HOSPITAL OF PHILADELPHIA $822,567 Grant Trans-NIH Recovery Act Research Support: Premature infants are a vulnerable population with multiple inter-related health problems that put them at risk for poor outcomes. Electronic health records capture large amounts of information that may help guide decisions, but existing alert and remind Health and Human Services, Department of / National Institutes of Health 8/01/2010
UNIVERSITY OF MIAMI $80,515 Grant Trans-NIH Recovery Act Research Support: As a mid-career investigator in applied behavioral and social sciences related to HIV/AIDS, my goal in applying for a Short-term Mentored Career Development Award (K-18) is to learn to employ hierarchical linear modeling/structural equation modeling analy Health and Human Services, Department of / National Institutes of Health 9/20/2010
MAYO CLINIC $496,120 Grant Trans-NIH Recovery Act Research Support: Functional dyspepsia is a common, chronic and costly disorder that substantially impairs quality of life for many Americans. The pathogenesis is unclear but abnormalities of gastric motor and sensory function have been identified; it is uncertain if the r Health and Human Services, Department of / National Institutes of Health 7/02/2010
SOUND TECHNOLOGIES INC $76,700 Contract : Tru-DR Digital Radiograp Detector, Tru-DR a'Cappella, Tru-DR Workstation,Monitor,Generator,Training and shipping Health and Human Services, Department of / National Institutes of Health 3/18/2010
WRIGHT STATE UNIVERSITY $82,270 Grant Trans-NIH Recovery Act Research Support: The health and structure of a child's skeleton is vital to his or her overall physical well-being. While there are numerous physiological and environmental factors that can alter pediatric skeletal health, there are three essential components: the geneti Health and Human Services, Department of / National Institutes of Health 7/27/2010
UNIVERSITY OF MARYLAND $81,270 Grant Trans-NIH Recovery Act Research Support: The recovery of useful hand function after stroke is a major scientific challenge for stroke treatment today particularly for those with more severe paresis. In this population recovery mechanisms may differ from those with mild hemiparesis and may involv Health and Human Services, Department of / National Institutes of Health 7/07/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $378,000 Contract : RECOVERY: Computational Thinking to Support Clinicians and Biomedical Scientists Health and Human Services, Department of / National Institutes of Health 9/23/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $82,768 Grant Trans-NIH Recovery Act Research Support: The supplement will accelerate work directly proposed in the parent grant. Technical and conceptual progress in our lab in the study of regeneration has enabled deeper analysis of signaling during regeneration than has been possible in the past. Funds a Health and Human Services, Department of / National Institutes of Health 9/02/2010
RESEARCH TRIANGLE INSTITUTE $872,224 Grant Trans-NIH Recovery Act Research Support: This supplemental funding will extend and enhance communication, coordination and outreach efforts under way to develop a set of consensus standard measures used in genetic/genomic research to describe various phenotypes and exposures (the PhenX project). Health and Human Services, Department of / National Institutes of Health 7/30/2009
BRIGHAM AND WOMEN'S HOSPITAL, INC., THE $3,126,139 Grant Trans-NIH Recovery Act Research Support: This application addresses Grand Opportunity: Phase 2 Clinical Trials Program of Novel Therapies for HLB Diseases. Obstructive sleep apnea (OSA) afflicts > 5% of adults and is associated with a 2 to 4-fold increased risk of cardiovascular disease (CVD). D Health and Human Services, Department of / National Institutes of Health 9/07/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $214,512 Grant Trans-NIH Recovery Act Research Support: Diabetes mellitus (DM) is increasingly prevalent among youth, forecasting early complications. Type 1 (T1D) and Type 2 diabetes (T2D) cause premature cardiovascular disease (CVD), shortening lifespan despite advances in glycemic control and CV risk factor Health and Human Services, Department of / National Institutes of Health 7/30/2010
TRUSTEES OF INDIANA UNIVERSITY $231,000 Grant Trans-NIH Recovery Act Research Support: The quest for improved Parathyroid hormone (PTH) efficacy has prompted the search for synergizers of PTH, i.e., pathways that accentuate PTH effects in the skeleton. One such synergistic stimulus is mechanical signaling. The molecular basis underlying the Health and Human Services, Department of / National Institutes of Health 7/19/2010
WASHINGTON UNIVERSITY, THE $248,871 Grant Trans-NIH Recovery Act Research Support: Guatemala is undergoing an epidemiological transition and today faces the 'double-burden' disease problem of significant infectious and non-infectious disease. However, prevalence and mortality rates of non-infectious disease are limited by an unreliable, Health and Human Services, Department of / National Institutes of Health 9/26/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $172,529 Grant Trans-NIH Recovery Act Research Support: This Administrative Supplement meets the overarching objectives of the ARRA Administrative Supplement by accelerating the tempo and enhancing the parent R01 project ?Development of the Functional Neural Systems for Face Expertise? (R01 HD060595; PI: Frank Health and Human Services, Department of / National Institutes of Health 7/27/2010
UNIVERSITY OF CALIFORNIA, IRVINE $50,654 Grant Trans-NIH Recovery Act Research Support: The specific aims of the parent grant are: 1) To establish the structural and functional alterations present in DS mitochondria; and 2) To characterize the molecular determinants of mitochondrial structural and functional alterations in DS. More specific Health and Human Services, Department of / National Institutes of Health 7/21/2010
OCHSNER CLINIC FOUNDATION $98,338 Grant Trans-NIH Recovery Act Research Support: The p66 gene has emerged as a genetic determinant of longevity, that controls mitochondrial metabolism and cellular responses to oxidative stress aging and apoptosis. The major hypothesis to be tested here is kidneys from p66-/- Akita mice will be resista Health and Human Services, Department of / National Institutes of Health 5/28/2010
ENVIRONMENT AND HEALTH GROUP, INC. $224,700 Grant Trans-NIH Recovery Act Research Support: The parent grant (2 R44 AG026815), E-Technology for Chinese Dementia Caregivers, supports a Phase II SBIR randomized trial that tests a web-based education and social support intervention for Chinese-speaking dementia caregivers. The proposed OppNet resea Health and Human Services, Department of / National Institutes of Health 9/22/2010
THE VANDERBILT UNIVERSITY $232,500 Grant Trans-NIH Recovery Act Research Support: The objective of this proposal is to better understand the regulation of glucose uptake and storage by the liver in vivo in the normal and insulin resistant state. The specific aims are: 1) to determine the importance of hormone and substrate sensing in Health and Human Services, Department of / National Institutes of Health 7/09/2010
UNIVERSITY OF CALIFORNIA, DAVIS $3,519,967 Grant Trans-NIH Recovery Act Research Support: High throughput design, synthesis and in vivo evaluation of targeted molecular imaging agents. This is a 3-year proposal in response to the RFA-OD-10-005. This proposal addresses components of all 5 thematic areas with the closest association with the the Health and Human Services, Department of / National Institutes of Health 9/25/2010
WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY $378,170 Grant Trans-NIH Recovery Act Research Support: The purpose of this grant is to purchase a JEOL JEM 1400 electron microscope with embedded CCD camera to serve as the sole EM available for research in a Core Facility at Weill Cornell Medical College. It will replace a 28 year-old JEOL 100 CX-II, which i Health and Human Services, Department of / National Institutes of Health 7/08/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $2,463,942 Grant Trans-NIH Recovery Act Research Support: Our goal is to develop and test a novel donor-specific, genomic approach to the non-invasive, early diagnosis of rejection and graft dysfunction after solid organ transplantation, and addresses two targeted thematic areas: 1) Applying Genomics and Other H Health and Human Services, Department of / National Institutes of Health 9/27/2010
SANFORD RESEARCH / USD $337,133 Grant Trans-NIH Recovery Act Research Support: This administrative supplement is designed to expand participant recruitment at the Rapid City one of the study locations in the Northern Plains Comprehensive Clinical Site of the Safe Passage Study. The Prenatal Alcohol in SIDS and Stillbirth (PASS) Net Health and Human Services, Department of / National Institutes of Health 9/16/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $244,450 Grant Trans-NIH Recovery Act Research Support: The awarded parent grant is exploring the relationship of structural effects of poverty and food insecurity on HIV vulnerability and child malnutrition among the rural poor in Malawi, but core concepts are highly relevant to the US. The study tests the hy Health and Human Services, Department of / National Institutes of Health 7/21/2010
UNIVERSITY OF WASHINGTON $48,661 Grant Trans-NIH Recovery Act Research Support: The PI of this grant is an M.D., Ph.D. who is committed to academic research and recently completed his clinical training in the Division of Infectious Disease at the University of Washington in Seattle. The proposal describes a 5 year training program d Health and Human Services, Department of / National Institutes of Health 8/02/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $1,973,881 Grant Trans-NIH Recovery Act Research Support: Disproportionate loss of women faculty from top universities greatly compromises our nation's academic talent pool. Under my leadership, Stanford School of Medicine has enacted important structural interventions (tenure clock flexibility, childcare, mento Health and Human Services, Department of / National Institutes of Health 9/30/2010
FLORIDA STATE UNIVERSITY, THE $97,381 Grant Trans-NIH Recovery Act Research Support: The specific aim of this supplement is to increase the rigor and pace of inquiry of the current study in the following ways: (a) take advantage of the treated control group design to examine CXI interactions in mathematics; (b) increase the pace of coding Health and Human Services, Department of / National Institutes of Health 9/07/2010
GE HEALTHCARE BIO-SCIENCES CORP. $160,000 Contract : Purchase of: One SYS 12903 MANUAL VP CAPILLARY DSC SYSTEM One SYS 12905 SYSTEM UPGRADE TO VP CAPILLARY DSC Health and Human Services, Department of / National Institutes of Health 9/21/2010
OHIO STATE UNIVERSITY, THE $76,250 Grant Trans-NIH Recovery Act Research Support: This research proposal seeks to answer fundamental questions on the contractile machinery of the bladder, specifically to determine the functional relevance of SM1 and SM2 myosin isoforms (that differ in the C-terminus). We have shown previously that alte Health and Human Services, Department of / National Institutes of Health 8/15/2010
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $379,250 Grant Trans-NIH Recovery Act Research Support: 'The proposed research is aimed at better understanding the neural underpinnings of cognitive reserve (CR). We have postulated that CR mediates the relationship between age- or Alzheimer+?G??G??s disease (AD)-related brain pathology and the clinical im Health and Human Services, Department of / National Institutes of Health 9/14/2010
ALBERT EINSTEIN COLLEGE OF MEDICINE $5,630,177 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant application focuses upon the Apicomplexa, etiologic agents of many diseases in the developing world and relevant to global health (thematic area 4). It uses genomics and other high throughput technologies (thematic area Health and Human Services, Department of / National Institutes of Health 9/29/2010
UNIVERSITY OF CALIFORNIA, LOS ANGELES $20,266 Grant Trans-NIH Recovery Act Research Support: Investigators at the Center for Gene Environment in Parkinson's (CGEP) study how environmental factors such as pesticides, interact with genetic variations to increase the risk for PD. The ARRA summer stipend provided support for 5 high school students to Health and Human Services, Department of / National Institutes of Health 5/28/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $379,710 Grant Trans-NIH Recovery Act Research Support: The epithelium of the small intestine undergoes a remarkable series of morphogenic changes during its development. The endodermally derived epithelial tube is initially comprised of a single layer of short columnar cells. Between E10.5 and E14.5, the epit Health and Human Services, Department of / National Institutes of Health 8/16/2010
ULTRADIAN DIAGNOSTICS, LLC $191,228 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): To date, the use of marketed continuous glucose monitoring systems (CGMs) are limited to glucose trend analysis by patients with insulin-dependent type 1 and type 2 diabetes. Accuracy limitations, particularly in the h Health and Human Services, Department of / National Institutes of Health 8/09/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $139,495 Grant Trans-NIH Recovery Act Research Support: In this quarter, we completed structured interviews with six professionals and are currently working on transcribing the information. We are continuing with recruitment of participants for the second community focus group and additional professionals for Health and Human Services, Department of / National Institutes of Health 8/03/2010
MISSOURI SYSTEM, UNIVERSITY OF $183,185 Grant Trans-NIH Recovery Act Research Support: We need a state-of-the-art method for BPA analysis. The purchase of an LC-MS/MS will provide a more definitive fingerprint of the molecules we're interested in. Health and Human Services, Department of / National Institutes of Health 9/23/2010
UNIVERSITY OF UTAH, THE $821,972 Grant Trans-NIH Recovery Act Research Support: The overall goal of our research is to elucidate underlying mechanisms, pathways and biological markers which may predispose individuals to advanced age-related macular degeneration (AMD) so that appropriate preventive and therapeutic targets can be devel Health and Human Services, Department of / National Institutes of Health 9/30/2010