Recovery Tracker

How Much Stimulus Funding is Going to Your County?

Listing all stimulus spending by amount, in descending order. Return to National Institutes of Health page

Amount refers to both the amount of stimulus funding going toward the project and the face value of the loan.

Recipient Amount Type Description Federal Dept./Agency Date
THE VANDERBILT UNIVERSITY $159,900 Grant Trans-NIH Recovery Act Research Support: This shared instrumentation grant is for the purchase of a digital, real-time autoradiography system with multiple radiolabel capability. The NIH-funded research projects that require this system are aimed primarily at developing new molecular imaging age Health and Human Services, Department of / National Institutes of Health 7/29/2010
WAKE FOREST UNIVERSITY $999,346 Grant Trans-NIH Recovery Act Research Support: The Forsyth County Healthy Living Collaborative (FCHL Collaborative) is a partnership among Wake Forest University Health Sciences (WFUHS), Communities Helping All Neighbors Gain Empowerment (CHANGE), the Forsyth County Department of Public Health (FCDPH) Health and Human Services, Department of / National Institutes of Health 8/13/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $130,030 Grant Trans-NIH Recovery Act Research Support: The goal of the Center for Reproductive Science and Medicine at UCSD is to develop understanding of the mechanisms that govern normal and disordered function of the hypothalamic-pituitary-ovarian axis. This application represents our renewal for years 29- Health and Human Services, Department of / National Institutes of Health 8/26/2010
TREVENA, INC. $7,639,642 Grant Trans-NIH Recovery Act Research Support: Approximately one third of today's FDA-approved drugs act on G-protein coupled receptors (GPCRs), collectively affecting hundreds of millions of people worldwide. In this project, Trevena proposes to demonstrate the broad applicability of functionally sel Health and Human Services, Department of / National Institutes of Health 9/30/2009
GEORGE MASON UNIVERSITY $295,135 Grant Trans-NIH Recovery Act Research Support: The long term goal of our research is to understand how the RNAi mechanism affects HIV-1 viral replication. DESCRIPTION: Human Immunodeficiency Virus type I (HIV-1) is the etiologic agent of Acquired Immunodeficiency Syndrome (AIDS). AIDS is a compl Health and Human Services, Department of / National Institutes of Health 6/25/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $33,482 Grant Trans-NIH Recovery Act Research Support: Our project addresses key issues in adult-to-adult living donor liver transplantation (LDLT). The Main Trial is an extension of the ongoing A2ALL Study - our program is an active participant and the leading enroller of patients to this trial. The current Health and Human Services, Department of / National Institutes of Health 9/30/2010
UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC. $170,879 Grant Trans-NIH Recovery Act Research Support: Disordered and/or delayed communication and language development constitute a defining characteristic of mental retardation. The proposed research is guided by a conceptualization of communication and language development that stresses the central role of Health and Human Services, Department of / National Institutes of Health 8/25/2010
G BAILEY COMPANY, INC $3,379,910 Contract : RECOVERY - Replace Steam Line and Manhole 69. Health and Human Services, Department of / National Institutes of Health 9/03/2010
UNIVERSITY OF UTAH, THE $171,990 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The pathogenesis of cerebral malaria (CM) is poorly understood. We discovered that Tanzanian children with CM have markedly low plasma levels of arginine (Arg) and markedly elevated phenylalanine (Phe). Arg is needed f Health and Human Services, Department of / National Institutes of Health 7/06/2010
BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE $128,812 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): We will establish the Intestinal Stem Cell Consortium Coordinating Center (ISCC-CC) at City of Hope. The ISC-CC will be under the direction of Dr. Joyce C. Niland, Chair of Information Sciences. The overall objective o Health and Human Services, Department of / National Institutes of Health 9/30/2010
SRI INTERNATIONAL $8,000,000 Contract : Work Assignment 17: RECOVERY -'IN VIVO SCREENING OF COMBINATIONS OF DRUGS TO TREAT CANCER We will test 121 drug combinations in three xenograft models. Test compounds and route of administration will be determined by the COTR. Tumor cell lines will be sel Health and Human Services, Department of / National Institutes of Health 9/03/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $169,176 Grant Trans-NIH Recovery Act Research Support: Development of a software pipeline that automates the process of generating gene function predictions from integrated genomic evidence Health and Human Services, Department of / National Institutes of Health 8/05/2010
UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC. $149,912 Grant Trans-NIH Recovery Act Research Support: This supplement addresses the Challenge Area (05) Comparative Effectiveness Research (CER) and the specific Challenge Topic posed by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Antihypertensive Drugs and Level of Blood Pr Health and Human Services, Department of / National Institutes of Health 9/30/2010
UNIVERSITY OF CALIFORNIA, LOS ANGELES $227,721 Grant Trans-NIH Recovery Act Research Support: Title: IFN-a and pDC in HIV infection: Impact on T cell development and reconstitution The immunosuppressive effects of IFN a outweigh its antiviral activity thereby contributing to HIV-1 pathogenesis. Thus it is imperative to elucidate factors that are r Health and Human Services, Department of / National Institutes of Health 9/27/2010
MICHIGAN STATE UNIVERSITY $1,109,565 Grant Trans-NIH Recovery Act Research Support: Comparative effectiveness research (CER) holds significant promise to improve health care quality although it faces methodological challenges in fulfilling this promise. The current CER framework does not directly meet the stated goal of CER to identify ' Health and Human Services, Department of / National Institutes of Health 9/27/2010
MCDONOUGH BOLYARD PECK, INC. $8,062,113 Contract : The proposed project is an incremental renovation of the F Wing of Building 10 (Floors 2-14) on the NIH campus in Bethesda, Maryland. Due to partial occupancy of some areas within the F wing and funding sources, the project is designed to be accomplished Health and Human Services, Department of / National Institutes of Health 8/30/2010
BAYLOR RESEARCH INSTITUTE, THE $499,875 Grant Trans-NIH Recovery Act Research Support: This work will address the challenge in human mucosal immunology. It will have a broad impact in science and health as it will provide fundamental knowledge in the immunology of the human genital tract, particularly the vagina, which is a major site of in Health and Human Services, Department of / National Institutes of Health 9/29/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $244,734 Grant Trans-NIH Recovery Act Research Support: The hypocretins (Hcrts), also known as orexins, are two hypothalamic neuropeptides, discovered by the applicant, with key functions in arousal maintenance, acute stress and brain reward function (de Lecea et al., 1998; de Lecea and Sutcliffe, 2005). The o Health and Human Services, Department of / National Institutes of Health 9/20/2010
UNIVERSITY OF IOWA, THE $50,000 Grant Trans-NIH Recovery Act Research Support: In this K01 application, Philip Polgreen, MD, seeks to gain expertise in graph theory pertaining to social networks and in mathematical simulations for developing more effective interventions to minimize the spread of nosocomial infections (specifically i Health and Human Services, Department of / National Institutes of Health 8/02/2010
ARIZONA STATE UNIVERSITY $336,943 Contract : RECOVERY:Computational Thinking to Support Clinicians and Biomedical Scientists. Text mining of clinical narratives: porting semi-supervised concept and relationship extraction techniques from biomedical literature mining. Health and Human Services, Department of / National Institutes of Health 9/21/2010
UNIVERSITY OF CALIFORNIA, LOS ANGELES $1,247,695 Grant Trans-NIH Recovery Act Research Support: Monetary incentives and intrinsic motivation to sustain hypertension control Hypertension affects over 70 million Americans, is responsible for one-sixth of deaths, and costs more than $70 billion annually. It disproportionately affects African-American Health and Human Services, Department of / National Institutes of Health 9/21/2010
FLORIDA STATE UNIVERSITY, THE $465,105 Grant Trans-NIH Recovery Act Research Support: There is a pressing need to improve early detection of ASD so that families can access intensive, appropriate intervention services as early as possible. However, studies indicate that important racial and ethnic disparities exist in the identification an Health and Human Services, Department of / National Institutes of Health 9/17/2009
REGENTS OF THE UNIVERSITY OF COLORADO, THE $50,000 Grant Trans-NIH Recovery Act Research Support: Severe acute respiratory syndrome (SARS), caused by a new human coronavirus (SARS-CoV), represents the 21st century's first pandemic caused by a previously unknown etiological agent. The 2002-03 SARS epidemic stimulated research on coronaviruses of humans Health and Human Services, Department of / National Institutes of Health 8/02/2010
RAND CORPORATION, THE $1,249,939 Grant Trans-NIH Recovery Act Research Support: Dementia is a condition that is growing in prevalence and which harms not only the afflicted individual but also adversely affects the health of their family and other informal caregivers. New methods for delivering comprehensive assistance to persons wit Health and Human Services, Department of / National Institutes of Health 9/24/2010
GEORGIA HEALTH SCIENCES UNIVERSITY RESEARCH INSTITUTE, INC. $343,182 Grant Trans-NIH Recovery Act Research Support: The Animal Models of Diabetic Complications Consortium (AMDCC) and the Mouse Metabolic Phenotyping Centers (MMPC) are two multi-center initiatives funded by the NIH. During the current five year funding cycle, the AMDCC had the primary responsibility of d Health and Human Services, Department of / National Institutes of Health 9/30/2010
NTVI ENTERPRISES, LLC $1,796,493 Contract : Building 3, Activation Move Services and Furniture Services. Health and Human Services, Department of / National Institutes of Health 9/28/2010
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY $433,243 Grant Trans-NIH Recovery Act Research Support: This is a application to purchase a Computer Cluster to support seven NIH-funded research groups carrying out research in computational and structural biology, structural genomics, and proteomics. We propose to acquire 96 compute nodes with two quad-core Health and Human Services, Department of / National Institutes of Health 7/22/2010
ASTERAND INC. $5,360,978 Contract : We have been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically to establish a Tissue Source Site (TSS) Network capable of delivering clinically annotated biospecimens through either or both retr Health and Human Services, Department of / National Institutes of Health 9/24/2010
LONZA WALKERSVILLE, INC. $70,157 Contract : NHBE - Bronchial Epi Cells - Cat number CC-2541W12 - & CC-2540 Cells Deliver to 3E19A3. These cells are standard off the shelf products (UOM - EA or AMP). As customer needs product, they will shipped from stored inventory. Health and Human Services, Department of / National Institutes of Health 9/22/2010
PUGET SOUND BLOOD CENTER PROGRAM $108,000 Grant Trans-NIH Recovery Act Research Support: Acute lung injury (ALI) is a severe complication of trauma with major short and long-term consequences. ALI is the earliest and most frequent manifestation of multiple organ failure, the leading cause of death among trauma victims surviving their injury a Health and Human Services, Department of / National Institutes of Health 8/03/2010
UNIVERSITY OF CALIFORNIA, LOS ANGELES $228,744 Grant Trans-NIH Recovery Act Research Support: The gastric H,K ATPase is the enzyme responsible for gastric acid secretion. Inhibition of this pump by proton pump inhibitors (PPIs) such as omeprazole, lansoprazole, pantoprazole, rabeprazole and esomeprazole are the main type of drug therapy used today Health and Human Services, Department of / National Institutes of Health 8/04/2010
UNIVERSITY OF NEBRASKA $199,981 Grant Trans-NIH Recovery Act Research Support: This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in oth Health and Human Services, Department of / National Institutes of Health 9/20/2010
VISION MECHANICS, INC $8,940 Contract : Fareday cage for two photon system 5X8 Health and Human Services, Department of / National Institutes of Health 9/29/2010
CHILDREN'S HOSPITAL MEDICAL CENTER $108,752 Grant Trans-NIH Recovery Act Research Support: During the period of the ARR a supplement for NICHD grant number R01-HD38578 we have been able to accomplish the primary aims of the proposed work. We successfully collected MEG data from the children in the longitudinal cohort using the same language tas Health and Human Services, Department of / National Institutes of Health 7/27/2010
MEDICAL UNIVERSITY OF SOUTH CAROLINA $363,805 Grant Trans-NIH Recovery Act Research Support: Walking is important to persons who have had a stroke and better rehabilitation methods are needed to restore or improve their walking. This project will find new and better ways to measure walking performance that are explicitly linked to specific underl Health and Human Services, Department of / National Institutes of Health 9/07/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $74,028 Grant Trans-NIH Recovery Act Research Support: Varicella zoster virus (VZV) causes varicella during primary infection, persists in sensory ganglia and may reactivate from latency to cause zoster. VZV pathogenesis depends upon its tropisms for T cells, skin and sensory ganglia. VZV vaccines to prevent Health and Human Services, Department of / National Institutes of Health 8/16/2010
ALBERT EINSTEIN COLLEGE OF MEDICINE $66,084 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This proposal responding to RFA-OD-10-005, Recovery Act Limited Competition: NIH Director's Opportunity for Research in Five Thematic Areas (RC4) fully addresses Research Area 2: Translating Basic Science Discoveries i Health and Human Services, Department of / National Institutes of Health 9/28/2010
OKLAHOMA MEDICAL RESEARCH FOUNDATION $0 Grant Trans-NIH Recovery Act Research Support: Systemic lupus erythematosus (SLE) has pleomorphic disease expression and a fundamental humoral autoimmune character. Disease manifestations are a virtual smorgasbord of clinical features that vary greatly from patient to patient and include dermatitis, Health and Human Services, Department of / National Institutes of Health 9/07/2010
NSABP FOUNDATION, INC. $188,932 Grant Trans-NIH Recovery Act Research Support: The American Cancer Society estimated that in 2004, breast or colorectal cancer would strike over 350,000 Americans and close to 100,000 people would die from these diseases. The National Surgical Adjuvant Breast and Bowel Project(NSABP) is a multi-center Health and Human Services, Department of / National Institutes of Health 7/02/2010
UNIVERSITY OF WASHINGTON $145,639 Grant Trans-NIH Recovery Act Research Support: The goal of our proposal is to develop a statistical framework forprobabilistic population projections and for assessing uncertainty inlinked demographic-disease models. This will yield probability-basedprediction intervals around all outputs of the model Health and Human Services, Department of / National Institutes of Health 8/18/2010
WHITING-TURNER CONTRACTING COMPANY, THE $157,030,324 Contract : Construction of the NIH Porter Neuroscience Research Center Phase II. The project is approximately 300,000 GSF. Health and Human Services, Department of / National Institutes of Health 5/13/2010
WILLIAM MARSH RICE UNIVERSITY $1,630,720 Grant Trans-NIH Recovery Act Research Support: Rice University is proposing the acquisition of a 24 TeraFLOP Computational Biology Cluster, based on the new Intel Nehalem technology, and equipped with hybrid InfiniBand/GigE interconnect to support both tightly coupled MPI and loosely coupled high-thro Health and Human Services, Department of / National Institutes of Health 8/12/2010
UNIVERSITY OF OREGON $196,846 Grant Trans-NIH Recovery Act Research Support: The research proposed in this supplementary application will expand the focus of a parent grant that examines the core determinants of capacity limits in Working Memory (WM). Is capacity limited by a maximum number of items that can be represented simulta Health and Human Services, Department of / National Institutes of Health 9/30/2010
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK $414,744 Grant Trans-NIH Recovery Act Research Support: The type III secretion system (TTSS) is essential for the pathogenesis of a number of gram-negative human pathogens, including three Yersinia species; Y. pseudotuberculosis and Y. enterocolitica, that cause infection of intestinal lymphoid tissues, and Y. Health and Human Services, Department of / National Institutes of Health 9/01/2009
TEXAS AGRILIFE RESEARCH $73,250 Grant Trans-NIH Recovery Act Research Support: Fifteen percent of babies born with a weight less than 1500 g die before being discharged from the hospital and 2 to 5% die within two years from complications. Those infants who survive two years are frequently disabled and prone to a lifetime of multipl Health and Human Services, Department of / National Institutes of Health 8/25/2010
MARQUETTE UNIVERSITY $73,399 Grant Trans-NIH Recovery Act Research Support: This project analyzes disordered control of posture and movement during reaching in patients with stroke resulting from middle cerebral artery occlusion. Prior studies have shown that control of posture and movement may both be impaired, and contribute im Health and Human Services, Department of / National Institutes of Health 7/30/2010
UNIVERSITY OF CALIFORNIA, DAVIS $153,733 Grant Trans-NIH Recovery Act Research Support: Metrics and Models for Measuring Behavioral Development in Rodents. The proposed research has two basic aims: The first aim is to determine what kinds of behavioral metrics in infant rats are most predictive of adult behaviors. The approach developed here Health and Human Services, Department of / National Institutes of Health 9/01/2010
BROWN UNIVERSITY IN PROVIDENCE IN STATE OF RI AND PROVIDENCE PLANTATIONS $405,000 Grant Trans-NIH Recovery Act Research Support: During the previous funding period we found that Killer Cell Lectin Like Receptor G1 (KLRG1), an evolutionary conserved inhibitory receptor expressed at the Natural Killer (NK) cell surface is a ligand for N-cadherin and E-cadherin molecules. Our recent p Health and Human Services, Department of / National Institutes of Health 7/20/2010
UNIVERSITY OF ILLINOIS $204,885 Grant Trans-NIH Recovery Act Research Support: Oral carcinoma have a high incidence of poor response to treatment and worldwide they produce high levels of mortality that has not changed for decades. There is needed novel methods to detect and diagnose oral carcinoma as early as possible. Many patient Health and Human Services, Department of / National Institutes of Health 8/09/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $361,206 Grant Trans-NIH Recovery Act Research Support: The prevalence of non-alcoholic fatty liver disease (NAFLD) and its severe phenotype, non-alcoholic steatohepatitis (NASH), are increasing significantly in the United States in the adult and pediatric population. NAFLD is associated with obesity and meta Health and Human Services, Department of / National Institutes of Health 9/30/2010
UNIVERSITY OF PUERTO RICO $426,768 Grant Trans-NIH Recovery Act Research Support: This is an application for a R15 that seeks to examine the relationship between a) the efficacy of cognitive behavioral therapy (CBT) and fluoxetine treatment in adolescents with a positive diagnosis for major depressive disorder (MDD), and b) brain struc Health and Human Services, Department of / National Institutes of Health 6/30/2010
WASHINGTON UNIVERSITY, THE $1,499,998 Grant Trans-NIH Recovery Act Research Support: NEW OBSERVATIONAL DATA ANALYSIS METHODS FOR COMPARATIVE EFFECTIVENESS RESEARCH Comparative effectiveness research (CER) is designed to identify healthcare interventions having the best patient outcomes to direct patients to receive the best treatment and Health and Human Services, Department of / National Institutes of Health 8/24/2010
YALE UNIVERSITY $111,757 Grant Trans-NIH Recovery Act Research Support: The proposed longitudinal study is designed to examine reading development at critical points in its establishment (from ages 7.5-10.5) in nonimpaired (Nl) and reading disabled (RD) cohorts. Our previous cross sectional research has identified reading gro Health and Human Services, Department of / National Institutes of Health 7/30/2010
THERMO ELECTRON NORTH AMERICA LLC $12,110 Contract : Laboratory equipment Health and Human Services, Department of / National Institutes of Health 9/29/2010
REGENTS OF THE UNIVERSITY OF MINNESOTA $199,846 Grant Trans-NIH Recovery Act Research Support: Currently, there are 7.7 million smokeless tobacco users in the U.S. Smokeless tobacco use has been associated with increased risk of oral pathologies (including oral cancer), pancreatic cancer, diabetes and other components of the metabolic syndrome, fet Health and Human Services, Department of / National Institutes of Health 9/01/2010
WASHINGTON METROPOLITAN AREA TRANSIT AUTHORITY $69,415 Contract : These ARRA funds provided SmartBenefits on SmarTrip cards to NIH employees that they may use to ride MetroBus or MetroRail. The fare media may also be used on DASH, Ride On, Fairfax Connector, ART, CUE, Loudoun County Transit, Omniride, TheBus, DC Circula Health and Human Services, Department of / National Institutes of Health 3/23/2010
EMORY UNIVERSITY $3,213,142 Grant Trans-NIH Recovery Act Research Support: A major challenge in vaccinology is that the efficacy of a vaccine can only be ascertained retrospectively, upon infection. The identification of molecular signatures induced rapidly after vaccination, which correlate with and predict, the later developme Health and Human Services, Department of / National Institutes of Health 7/12/2010
BAYLOR COLLEGE OF MEDICINE $124,650 Grant Trans-NIH Recovery Act Research Support: Purpose: To test the hypothesis that coactivator posttranslational modifications control the in vivo systems biology of mammals. Health and Human Services, Department of / National Institutes of Health 9/30/2010
REGENTS OF THE UNIVERSITY OF MINNESOTA $55,460 Grant Trans-NIH Recovery Act Research Support: Human infections by the intracellular bacterial pathogens Chlamydia trachomatis and C pneumoniae present an enormous health care problem. Infections by these pathogens have been associated with engendering and/or exacerbating several chronic diseases, and Health and Human Services, Department of / National Institutes of Health 8/30/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $99,930 Grant Trans-NIH Recovery Act Research Support: The purpose of the study is to evaluate the efficiency of a risk assessment algorithm in identifying subjects with suspicious pre-cancerous or cancerous lesions in high risk population, as compared to broad screening in the general population. To test the Health and Human Services, Department of / National Institutes of Health 9/09/2010
MICHIGAN STATE UNIVERSITY $5,022 Grant Trans-NIH Recovery Act Research Support: This supplemental award supports the summer research of two undergraduate students at Michigan State University. The funds will accelerate the research supported by a Research Scholar Development Award, assist the development of young scientists, and crea Health and Human Services, Department of / National Institutes of Health 6/28/2010
UNIVERSITY OF MIAMI $65,912 Grant Trans-NIH Recovery Act Research Support: Heritable factors are responsible for 70-80% of the variability in the timing of puberty. However, the mechanism that initiates puberty, and thus the genetic causes of abnormal pubertal development is still unknown. The majority of the new developments in Health and Human Services, Department of / National Institutes of Health 8/26/2010
RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE $161,432 Grant Trans-NIH Recovery Act Research Support: Spirochetes are a medically significant but poorly understood group of bacteria. These organisms cause several important human diseases, such as syphilis, Lyme disease and leptospirosis. Spirochetes are very diverse, but they share a special attribute: Sp Health and Human Services, Department of / National Institutes of Health 7/06/2010
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH $220,860 Grant Trans-NIH Recovery Act Research Support: iNKT cells are extremely potent first responders to infection. The aggressive nature of these cells has made them attractive targets for immunotherapy. Like conventional T cells, iNKT cells develop in the thymus from hematopoietic precursor cells that com Health and Human Services, Department of / National Institutes of Health 7/12/2010
CELLULAR TECHNOLOGY LIMITED $84,320 Contract : LABORATORY EQUIPMENT Health and Human Services, Department of / National Institutes of Health 9/17/2010
UNIVERSITY OF CALIFORNIA MERCED $304,000 Grant Trans-NIH Recovery Act Research Support: Hepatitis C virus (HCV) is a growing public health concern and is estimated to have infected nearly four to five million individuals in the U.S. alone. About 70 - 80 % of hepatitis C virus (HCV) infection results in chronic infection that can lead to sev Health and Human Services, Department of / National Institutes of Health 9/07/2010
EMORY UNIVERSITY $270,000 Grant Trans-NIH Recovery Act Research Support: Emory-Ethiopia Global Interdisciplinary Partnership. Building on unique partnerships with the CDC, CARE, the Carter Center, and the Task Force for Global Health, Emory University is already one of the nation's leading universities for reducing disease in Health and Human Services, Department of / National Institutes of Health 9/27/2010
UNIVERSITY OF CHICAGO, THE $78,000 Grant Trans-NIH Recovery Act Research Support: To study the role of cellular sulfation in embryonic brain development, the investigators have developed a novel inducible RNAi system to reduce the cellular levels of PAPS, the universal sulfate donor in the cell. They have generated transgenic mice whic Health and Human Services, Department of / National Institutes of Health 9/09/2010
MOUNT SINAI SCHOOL OF MEDICINE $372,330 Grant Trans-NIH Recovery Act Research Support: The prevalence of food allergy has increased over the past 2 decades and food allergy now affects 3.5% :o 4% of the U.S. population. Peanut allergy, which is the single leading cause of severe and fatal foodnduced allergic reactions in the U.S., affects 1 Health and Human Services, Department of / National Institutes of Health 7/19/2010
MOUNT SINAI SCHOOL OF MEDICINE $317,964 Grant Trans-NIH Recovery Act Research Support: Chronic allograft nephropathy (CAN) remains the most common cause of graft loss. However, the term CAN does not delineate the specific underlying pathologic process but rather refers to the chronic injury resulting from multiple potential factors. More re Health and Human Services, Department of / National Institutes of Health 8/02/2010
CELL SIGNALING TECHNOLOGY, INC. $150,018 Grant Trans-NIH Recovery Act Research Support: The parent grant supports the development of PhosphoSitePlus-? (PSP) a cutting-edge web-based biomedical research used weekly by thousands of researchers around the world. PSP aggregates information about protein post-translational modifications (PTMs) Health and Human Services, Department of / National Institutes of Health 9/28/2009
SIMULCONSULT, INC. $377,991 Contract : An Evidence-Based, Open Database Approach to Diagnostic Decision Support Health and Human Services, Department of / National Institutes of Health 9/20/2010
UNIVERSITY OF WASHINGTON $383,550 Grant Trans-NIH Recovery Act Research Support: Genital HIV-1 viral load is a major predictor of sexual and perinatal HIV transmission, and strategies to decrease HIV-1 shedding while promoting vaginal health are urgently needed. We hypothesize that Lactobacillus crispatus, a key component of the norma Health and Human Services, Department of / National Institutes of Health 9/20/2010
NORTHERN ILLINOIS UNIVERSITY INC $350,455 Grant Trans-NIH Recovery Act Research Support: Funds are being used to study oxygen levels in different positions and structures within the eye, under both normal and disease conditions, in order to improve knowledge of oxygen diffusion throughout the eye and its possible role in the etiology of disea Health and Human Services, Department of / National Institutes of Health 9/30/2010
REGENTS OF THE UNIVERSITY OF MINNESOTA $1,804,357 Contract : Among its other research projects, the Division of Epidemiology, Statistics and Prevention Research of the Eunice Kennedy Shriver National Institute of Child Health and Human Development is conducting the National Standard for Normal Fetal Growth Study. Health and Human Services, Department of / National Institutes of Health 9/27/2010
BAYLOR COLLEGE OF MEDICINE $1,657,258 Grant Trans-NIH Recovery Act Research Support: We propose to map and deposit a collection of well defined chemically induced mutations in essential genes on the Drosophila melanogaster X chromosome for distribution by the Bloomington Drosophila Stock Center (BDSC) to the fly community. This resource w Health and Human Services, Department of / National Institutes of Health 9/30/2010
OHIO STATE UNIVERSITY, THE $83,990 Grant Trans-NIH Recovery Act Research Support: Type I interleukin-1 receptor (IL-1R1) is the functional receptor for IL-1. IL-1 mediates numerous activities in the neuroendocrine, nervous, and immune systems. The transcriptional regulation of IL-1R1 is poorly understood. Current work in our lab has id Health and Human Services, Department of / National Institutes of Health 7/06/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $77,250 Grant Trans-NIH Recovery Act Research Support: Perceptual disorders are often measured through the inability to rapidly identify visual objects such as faces or words, but these deficits may reflect a change in the certainty associated with potential responses rather than a deficit in the underlying p Health and Human Services, Department of / National Institutes of Health 9/28/2010
UNIVERSITY OF CALIFORNIA, IRVINE $976,936 Grant Trans-NIH Recovery Act Research Support: The integrated, transformational strategies of the proposed Orange County Center for Community Health Research (OCCCHR) will potentially have a broad impact on health research and in the reduction of health disparities. The OCCCHR will utilize a state-of- Health and Human Services, Department of / National Institutes of Health 9/23/2010
OHIO STATE UNIVERSITY, THE $95,750 Grant Trans-NIH Recovery Act Research Support: Glutamate-mediated excitotoxicity is believed to be involved in the pathogenesis of many neurological disorders. Under disease conditions, elevated extracellular glutamate concentrations can occur when the release from presynaptic terminals is augmented o Health and Human Services, Department of / National Institutes of Health 8/05/2009
CYCORP, INC. $377,967 Contract : Conduct research feasibility studies that will: 1) develop and test computational approaches to one or more significant cognitive problems as commonly encountered by clinicians, clinical researchers, biologists, or patients; and b) bring improvement in me Health and Human Services, Department of / National Institutes of Health 9/20/2010
NEW YORK UNIVERSITY (INC) $1,231,890 Grant Trans-NIH Recovery Act Research Support: Behavioral economics represents a powerful, albeit underutilized tool by which to influence provider and systems behavior in a large-scale, meaningful, and sustainable way. We propose to use a sophisticated electronic health record (EHR) system to change Health and Human Services, Department of / National Institutes of Health 9/28/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $193,333 Grant Trans-NIH Recovery Act Research Support: This application for a methodological R21 builds upon the interest of examining potential approaches to using existing public use secondary data for the study of the Asian Pacific Islander racial category previously defined by the U.S. Census. With the ex Health and Human Services, Department of / National Institutes of Health 9/22/2010
UNIVERSITY OF TEXAS AT SAN ANTONIO $82,797 Grant Trans-NIH Recovery Act Research Support: More than 100,000 myocardial infarction (MI) patients undergo adverse remodeling of left ventricle (LV) and progress to congestive heart failure each year. Currently, the 5 year mortality rate for CHF is 50%. A lack of early diagnostic indicators and effe Health and Human Services, Department of / National Institutes of Health 9/06/2010
BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE $187,587 Grant Trans-NIH Recovery Act Research Support: potent inhibition of HIV-1 infection in cultured cells. We will extend our analyses of these constructs to primary CD34+ cells and T-lymphocytes as part of specific aim 1. In aim 2 further analyses of the functional role of HIV-1 RNA trafficking through t Health and Human Services, Department of / National Institutes of Health 8/23/2010
JOHNS HOPKINS UNIVERSITY, THE $50,000 Grant Trans-NIH Recovery Act Research Support: The objectives of the proposed studies are two-fold: 1) To investigate the mechanisms of the effects of cytokines and hormones on the regulation of rat class I alcohol dehydrogenase (ADH). These studies include characterization of trans-acting factors tha Health and Human Services, Department of / National Institutes of Health 8/09/2010
TRUSTEES OF BOSTON UNIVERSITY $826,561 Grant Trans-NIH Recovery Act Research Support: Trisomy 21 results in the constellation of phenotypes collectively termed Down syndrome (DS) and is one of the most prevalent congenital birth defects. Motor and sensory deficits and often severe mental retardation are among the many debilitating sequelae Health and Human Services, Department of / National Institutes of Health 9/02/2010
REGENX BIOSCIENCES, LLC $2,822,695 Grant Trans-NIH Recovery Act Research Support: The goal of this project is to develop a gene therapeutic for retinitis pigmentosa (RP). RP is the most common inherited form of blindness, and is characterized by photoreceptor loss, leading to a progressive loss of peripheral as well as night vision. Health and Human Services, Department of / National Institutes of Health 7/26/2010
TRUSTEES OF TUFTS COLLEGE INC $2,494,925 Grant Trans-NIH Recovery Act Research Support: Tufts CTSI Career Development Program in Comparative Effectiveness Research From its inception in 2008, a major goal of the Tufts Clinical and Translational Institute (CTSI) has been to develop a comprehensive infrastructure for the efficient conduct of Health and Human Services, Department of / National Institutes of Health 9/30/2010
OKLAHOMA STATE UNIVERSITY $418,998 Grant Trans-NIH Recovery Act Research Support: The WNT family of signaling molecules has been identified as potential key regulators of normal ovarian function in the adult female. It is known that WNT proteins are required for early ovarian development and that mice lacking Wnt4 have sex-reversed ova Health and Human Services, Department of / National Institutes of Health 7/07/2010
TRUSTEES OF INDIANA UNIVERSITY $299,790 Grant Trans-NIH Recovery Act Research Support: This administrative supplement proposal is to further develop online services to support clinical and translational science collaboration needs among researchers and in support of technology transfer to the health care industry. It is also to develop esse Health and Human Services, Department of / National Institutes of Health 9/18/2009
NET ESOLUTIONS CORPORATION $76,310 Contract : To develop and publish reports on the scientific outcomes resulting from research grants funded with Recovery Act dollars. Health and Human Services, Department of / National Institutes of Health 9/14/2010
MICHIGAN STATE UNIVERSITY $369,655 Grant Trans-NIH Recovery Act Research Support: There is a fundamental gap in understanding the neural bases for childhood developmental stuttering, particularly with respect to why certain children recover naturally whereas others continue to stutter throughout life and why there is a greater probabil Health and Human Services, Department of / National Institutes of Health 9/25/2010
UNIVERSITY OF ILLINOIS $58,651 Grant Trans-NIH Recovery Act Research Support: Persistent infection with Helicobacter pylori is a significant risk factor for a number of gastric disorders in humans, including peptic ulcer disease and gastric adenocarcinomas. The vacuolating cytotoxin(VacA) is an important virulance factor that cont Health and Human Services, Department of / National Institutes of Health 9/20/2010
MOUNT SINAI SCHOOL OF MEDICINE $101,750 Grant Trans-NIH Recovery Act Research Support: Molecular imaging of gene expression in vivo, in real time and at the cellular level is a rapidly growing area of medical research that will provide insight into the origin and progression of disease at the genetic level. Instrumentation for non-invasive Health and Human Services, Department of / National Institutes of Health 7/01/2010
UNIVERSITY OF KENTUCKY $222,750 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This application is in response to the NIDCD Research Grants for Translating Basic Research into Clinical Tools for Human Health (R21) (PAR-08-018). As individuals age, muscle weakness and neuromuscular disorders have Health and Human Services, Department of / National Institutes of Health 9/22/2010
VISION TECHNOLOGIES, INC $2,391,779 Contract : Installation of cabling for Bulding - B10 F-Wing - Phase B Health and Human Services, Department of / National Institutes of Health 5/27/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $332,800 Grant Trans-NIH Recovery Act Research Support: Exposure to prenatal inflammation, as occurs in many preterm births, is associated with a significant increased risk of adverse neurological outcomes. Ex preterm children are at dramatically increased risk of lower IQs, poor functioning in school as well Health and Human Services, Department of / National Institutes of Health 8/11/2010
MOUNT SINAI SCHOOL OF MEDICINE $486,489 Grant Trans-NIH Recovery Act Research Support: A high-throughput workstation for cell-based assays is requested for the use for researchers at the Mount Sinai School of Medicine. This system is comprised of a liquid handler integrated with a plate reader (with fluorescence, luminescence and absorbance Health and Human Services, Department of / National Institutes of Health 7/01/2010
GROUP HEALTH COOPERATIVE $1,499,873 Grant Trans-NIH Recovery Act Research Support: This project will develop a Mental Health Research Network (MHRN) including eight established public-domain research centers based in large, integrated not-for-profit health systems. Together, these health systems provide comprehensive health care to app Health and Human Services, Department of / National Institutes of Health 7/09/2010
NEW YORK UNIVERSITY (INC) $4,731,086 Grant Trans-NIH Recovery Act Research Support: This application addresses the broad Thematic Area 1, Applying Genomics and Other High Throughput Technologies, to study the transcriptional regulatory network that governs the differentiation of Th17 cells. Following infection with different microbes, C Health and Human Services, Department of / National Institutes of Health 9/27/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $83,163 Grant Trans-NIH Recovery Act Research Support: The success of our research critically depends on reliable non-invasive and invasive measurements of lung function in the mice. The PI conceived of and was an author of the first study to demonstrate that invasive measurements of lung function can be acco Health and Human Services, Department of / National Institutes of Health 8/03/2010
RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA $189,000 Grant Trans-NIH Recovery Act Research Support: Very low birth weight [VLBW] infants have an increased risk of brain injury [BI] and consequently, are more likely to exhibit signs of motor, cognitive, or behavioral impairment. Studies have examined the effects of Apolipoprotein E (APOE) genotype on out Health and Human Services, Department of / National Institutes of Health 9/09/2010
UNIVERSITY OF TEXAS M D ANDERSON $841,344 Grant Trans-NIH Recovery Act Research Support: The proposed Genome Data Analysis Center B (GDAC B) will work cooperatively with other GDACs funded by The Cancer Genome Atlas (TCGA) project to (i) develop an innovative, integrative pipeline for systems- level analysis of TCGA's molecular profiling data Health and Human Services, Department of / National Institutes of Health 9/22/2010
UNIVERSITY OF ALABAMA AT BIRMINGHAM $1,044,000 Grant Trans-NIH Recovery Act Research Support: The Alabama Neuroscience Blueprint Core Center (NS057098) was established in 2006 to provide neuroscience investigators at the University of Alabama at Birmingham (UAB) and participating institutions in the Southern United States access to state-of-the-ar Health and Human Services, Department of / National Institutes of Health 9/13/2010
UNIVERSITY OF MARYLAND $98,086 Grant Trans-NIH Recovery Act Research Support: The overall goal of the parent project is to characterize the gene network underlying vertebrate sex determination. The research takes advantage of four distinct sex determining systems (two XY and two WZ) among closely related species of cichlid fishes. Health and Human Services, Department of / National Institutes of Health 7/19/2010
BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE $410,248 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Chronic graft versus host disease (GVHD), an autoimmune-like collagen-vascular disease with clinical features similar to scleroderma and systemic lupus erythematosus (SLE), remains the major cause of morbidity and mort Health and Human Services, Department of / National Institutes of Health 7/12/2010
CHILDREN'S MEMORIAL HOSPITAL, THE $261,551 Grant Trans-NIH Recovery Act Research Support: Corneal ectasia, a warping and thinning of the anterior eye, afflicts 1 in 2000 of the general population. Its dynamic mechanism remains poorly understood, in part, due to its diverse and pleiotropic environmental and genetic causes. While treatment optio Health and Human Services, Department of / National Institutes of Health 9/27/2010
3-C INSTITUTE FOR SOCIAL DEVELOPMENT, INC. $240,741 Grant Trans-NIH Recovery Act Research Support: This supplement grant will build on the WDT-C Phase I project by creating a WDT treatment outcomes module and conducting an additional feasibility test. The proposed supplemental research is expected to demonstrate strong support for the treatment outcome Health and Human Services, Department of / National Institutes of Health 9/27/2010
CHILDREN'S HOSPITAL MEDICAL CENTER $381,250 Grant Trans-NIH Recovery Act Research Support: The purpose of the current award is to define the importance of the Guanylate Cyclase C (GC-C) signaling system in the pathogenesis of Inflammatory Bowel Disease (IBD). Our current work indicates that in both animal models systems as well as in pediatric Health and Human Services, Department of / National Institutes of Health 7/28/2010
YALE UNIVERSITY $184,890 Grant Trans-NIH Recovery Act Research Support: Our primary defense against infectious disease and re-occurring illness are memory T and B cells. These critical arms of the immune system can also be potent aggressors against many forms of cancer. Developing effective vaccines to prevent infection and t Health and Human Services, Department of / National Institutes of Health 7/26/2010
RESEARCH TRIANGLE INSTITUTE $1,494,669 Grant Trans-NIH Recovery Act Research Support: The project is providing support for 10 jobs at RTI international (1 full time 9 part-time), 2 part-time jobs at UNC Chapel Hill, and 2 part-time consultants from Yale University. In particular the project supports In this methodological study we will d Health and Human Services, Department of / National Institutes of Health 9/30/2010
UNIVERSITY OF MASSACHUSETTS $2,507,052 Grant Trans-NIH Recovery Act Research Support: 'This award was for a 3-year Director's opportunity award entitled ''Translating Dosage Compensation to Trisomy''. Our lab has long studied inactivation of one X-chromosome which provides for equal dosage of genes between males and females. While basi Health and Human Services, Department of / National Institutes of Health 9/30/2010
UNIVERSITY OF SOUTH FLORIDA $54,200 Grant Trans-NIH Recovery Act Research Support: The University of South Florida (USF), in its third year of a Fogarty AIDS International Training and Research Program (AITRP) grant focused on the state of Gujarat, India has identified improvement of local ethics board procedures as an area of strategic Health and Human Services, Department of / National Institutes of Health 9/24/2010
TRUSTEES OF INDIANA UNIVERSITY $137,475 Grant Trans-NIH Recovery Act Research Support: This request is being made to increase the scientific tempo of our research project under our currently approved aims. The ability to create a new research technician position in my lab will help bridge the cellular and in vitro data we are collecting for Health and Human Services, Department of / National Institutes of Health 8/09/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $80,584 Grant Trans-NIH Recovery Act Research Support: The goal of this renewal grant is to translate our pioneering studies on the biology of bone morphogenetic protein-15 (BMP-15) in rodents to the human. The rationale underpinning the grant is that mutations in the bmp15 gene cause infertility in women due Health and Human Services, Department of / National Institutes of Health 7/29/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $765,000 Grant Trans-NIH Recovery Act Research Support: ADPKD is the most common hereditary kidney disease, affecting 1 in 400 to 1000 individuals and accounting for 4% of end-stage renal disease in the United States and 8-10% in Europe. The condition is characterized by progressive development of kidney cysts Health and Human Services, Department of / National Institutes of Health 9/28/2010
UNIVERSITY OF WASHINGTON $95,040 Grant Trans-NIH Recovery Act Research Support: The ability to reason about other's behavior is a pervasive aspect of mature and developing cognition. In past work, I have significantly contributed to the field by demonstrating that infants possess a rich understanding of others' goals and intentions, Health and Human Services, Department of / National Institutes of Health 9/24/2010
UNIVERSITY OF OKLAHOMA $76,333 Grant Trans-NIH Recovery Act Research Support: The long-term goal is to employ a multidisciplinary approach to gain a thorough understanding of how the GTPase cycle is utilized in various biological systems to control specifically diverse cellular functions, including signal transduction, cytoskeleton Health and Human Services, Department of / National Institutes of Health 7/09/2010
RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA $269,500 Grant Trans-NIH Recovery Act Research Support: This proposal describes the development of an innovative training and research tool, a novel agent-based model (ABM), to address a critical global health challenge, the devastating toll of early childhood diarrhea (ECD). An ABM will be developed to simula Health and Human Services, Department of / National Institutes of Health 9/26/2010
KANSAS STATE UNIVERSITY $433,215 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The interferons (IFNs) are a multi-functional group of cytokines that participate in the implantation of the early embryo, maintenance of a successful pregnancy, initiation of innate immunity and regulation of adaptive Health and Human Services, Department of / National Institutes of Health 8/04/2010
UNIVERSITY OF UTAH, THE $669,992 Grant Trans-NIH Recovery Act Research Support: Address; Affect; African American; Afro American; Afroamerican; Area; BMI percentile; BMI z-score; Black Populations; Black or African American; Body Weight; Body Weight decreased; Body mass index; CAT Scan, X-Ray; CAT scan; CNP; CT X Ray; CT scan; Candid Health and Human Services, Department of / National Institutes of Health 8/06/2010
LOUISIANA STATE UNIVERSITY SYSTEM $222,000 Grant Trans-NIH Recovery Act Research Support: The purpose of the project is to determine how astrocytic leptin receptor (ObR) is involved in leptin transport from blood to the brain and how it is involved in neuronal leptin signaling in the context of adult-onset obesity. During the first quarter, Health and Human Services, Department of / National Institutes of Health 7/05/2010
CASE WESTERN RESERVE UNIVERSITY $647,060 Grant Trans-NIH Recovery Act Research Support: This Administrative Supplement application is in response to NOT-RR-10-001, NIH Announces the Availability of Recovery Act Funds for Administrative Supplements to Support Core Consolidation. The project is entitled G?Core Consolidation: Behavioral Measure Health and Human Services, Department of / National Institutes of Health 9/29/2010
UNIVERSITY OF PITTSBURGH THE $0 Grant Trans-NIH Recovery Act Research Support: Proteins are fundamental molecules that perform the functions of cell, and understanding the functions of proteins is a corner stone of modern biomedical research. Much of knowledge regarding proteins is stored in the form biomedical literature. The ove Health and Human Services, Department of / National Institutes of Health 9/28/2010
UNIVERSITY OF WISCONSIN SYSTEM $86,480 Grant Trans-NIH Recovery Act Research Support: The overall aim of the funded R01 is to investigate the factors associated with men becoming unwed fathers and the nature and consequences of unmarried fathers' involvement with children. Using three national datasets--the National Survey of Family Growth Health and Human Services, Department of / National Institutes of Health 7/01/2010
CHARLES RIVER LABORATORIES, INC. $28,550 Contract : National Institutes of Health intend to procure 5,600 Specific Pathogen-Free (SPF) Premium Plus Incubated Eggs for the purpose of supporting ongoing influenza projects within the division of Intramural Research, NIAID. Due to the critical public need for Health and Human Services, Department of / National Institutes of Health 9/09/2010
MONELL CHEMICAL SENSES CENTER $154,634 Grant Trans-NIH Recovery Act Research Support: This is an Administrative Supplement to grant: NIH RO1GrantHD37119, Model for Sensitive Periods in Early Flavor Learning. The overall goal of the grant is to discover the timing of the sensitive period in human flavor learning and its impact on later foo Health and Human Services, Department of / National Institutes of Health 7/27/2010
GEORGIA HEALTH SCIENCES UNIVERSITY RESEARCH INSTITUTE, INC. $327,900 Grant Trans-NIH Recovery Act Research Support: Campylobacter jejuni is a leading bacterial cause of gastroenteritis in the United States, and is responsible for sporadic disease as well as food-borne and water-borne outbreaks. It is also a Category B Bioterrorism Agent. There are at least 2 million Health and Human Services, Department of / National Institutes of Health 7/19/2010
THOMAS JEFFERSON UNIVERSITY $49,272 Grant Trans-NIH Recovery Act Research Support: Under the auspices of the parent grant, we have demonstrated that both morpholino antisense and a small drug molecule can inhibit ALDH2, both in vitro and in vivo, and as a consequence acetaldehyde leevls are increased. Thus, these agents may assist us i Health and Human Services, Department of / National Institutes of Health 8/20/2010
UNIVERSITY OF CALIFORNIA, DAVIS $305,789 Grant Trans-NIH Recovery Act Research Support: Comparative effectiveness research (CER) is a priority for the physical and economic health of the nation. Defined as the conduct and synthesis of research comparing the benefits and harms of different interventions and strategies to prevent, diagnose, t Health and Human Services, Department of / National Institutes of Health 9/09/2010
BAYLOR COLLEGE OF MEDICINE $102,335 Grant Trans-NIH Recovery Act Research Support: The goal of this project is to understand the mechanism of cell trafficking and inflammatory responses in nonlymphoid tissues in the settings of autoimmune diseases. CXCL16 is the second member of the chemokine family with a transmembrane domain. The rece Health and Human Services, Department of / National Institutes of Health 9/13/2010
UNIVERSITY OF MARYLAND $319,461 Grant Trans-NIH Recovery Act Research Support: Staphylococcus aureus is a gram positive, ubiquitous bacterial species, with the predominant reservoir in nature being humans. The increased use of implanted medical devices such as intramedullary rods, screws, plates, and artificial joints has provided a Health and Human Services, Department of / National Institutes of Health 8/16/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $449,693 Grant Trans-NIH Recovery Act Research Support: This application is an extension of our funded 2000 Trauma Center application and a resubmission of our competing renewal thaw was awarded bridge funding for 2004-2005. Our global hypothesis is that twoway exchanges between Human Core (housing clinical da Health and Human Services, Department of / National Institutes of Health 6/22/2010
REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE $52,615 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This application requests NICHD development support for population research at the University of California, Berkeley. The campus' long history of excellence in demographic teaching and research was recently enhan Health and Human Services, Department of / National Institutes of Health 9/02/2010
PRIMATE PRODUCTS, INCORPORATED $351,800 Contract : ARRA Influenza project - Animal model : Non-human primates are required for animal research studies using human influenza virus. The deliverables include: 72 Cynomolgus macaques and transportation. The animals will be requested on a per need basis in sepe Health and Human Services, Department of / National Institutes of Health 9/17/2010
ALBERT EINSTEIN COLLEGE OF MEDICINE $849,449 Grant Trans-NIH Recovery Act Research Support: This is an application for renewed CCSG funding for year 35 of the Albert Einstein Cancer Center which received its first NCI designation in 1972. There are seven established programs. These include: Immunooncology (Scharff), Tumor Microenvironment and Me Health and Human Services, Department of / National Institutes of Health 9/09/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $1,078,118 Grant Trans-NIH Recovery Act Research Support: The long-range objectives of the Colorado Learning Disabilities Research Center (CLDRC) are the identification, characterization, validation and amelioration of reading disabilities and ADHD, the two most prevalent and often co-morbid disorders of childho Health and Human Services, Department of / National Institutes of Health 9/07/2010
CHILDREN'S HOSPITAL CORPORATION, THE $181,084 Grant Trans-NIH Recovery Act Research Support: Developmental brain malformations are at the core of significant neurological diseases affecting many families in the United States and around the world. It is known that epilepsy, specific learning deficits and mental retardation, cerebral palsy, and abn Health and Human Services, Department of / National Institutes of Health 8/21/2009
UMDNJ-ROBERT WOOD JOHNSON MEDICAL SCHOOL $84,648 Grant Trans-NIH Recovery Act Research Support: Systems providing inducible gene regulation in mammalian cells have been of great experimental value. To date most systems regulate gene expression at the level of transcription initiation. Although these systems have been quite useful, there are some dr Health and Human Services, Department of / National Institutes of Health 8/09/2010
THE JACKSON LABORATORY $170,356 Grant Trans-NIH Recovery Act Research Support: The goal of R01 EY018605 is to understand how adhesion and matrix molecules confer recognition signals and cellular identifiers to neuronal cell types to mediate cell adhesion and avoidance during the development of the retina. The purpose of this ARRA ad Health and Human Services, Department of / National Institutes of Health 7/01/2010
GENEFLUIDICS, INC. $97,205 Grant Trans-NIH Recovery Act Research Support: The overall goal of this SBIR Phase I application is to develop and validate the prototyping fabrication process of a universal point-of-care (POC) system that is capable of adapting existing assay protocols for life science research and clinical diagnost Health and Human Services, Department of / National Institutes of Health 7/19/2010
YALE UNIVERSITY $192,314 Grant Trans-NIH Recovery Act Research Support: Autoantibodies are a characteristic of most autoimmune diseases including rheumatoid arthritis (RA) and appear in the serum many years before the onset of clinical disease, suggesting an early break in B cell tolerance in RA. An important role for B cells Health and Human Services, Department of / National Institutes of Health 8/30/2010
EMORY UNIVERSITY $169,225 Grant Trans-NIH Recovery Act Research Support: The title of this award is Spinal Circuits and the Musculoskeletal System. The goal of this research is to evaluate the effects of interventions aimed at restoration of function following injuries to peripheral nerves. Such injuries occur commonly and are Health and Human Services, Department of / National Institutes of Health 8/25/2010
UNIVERSITY OF CHICAGO, THE $2,435,723 Grant Trans-NIH Recovery Act Research Support: Comparative effectiveness research (CER) is the conduct and synthesis of systematic research comparing interventions and strategies to promote health and diagnose and treat disease. This research is intended to inform patients, providers, and decision-mak Health and Human Services, Department of / National Institutes of Health 9/30/2010
UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) $142,000 Grant Trans-NIH Recovery Act Research Support: This competitive revision R03 application is in response to Notice Number (NOT-OD-10-032) and Notice Title: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications (R01, R03, R15, R21, R21/R33, and R37) through the NIH B Health and Human Services, Department of / National Institutes of Health 9/27/2010
UNIVERSITY HEALTH NETWORK $257,920 Contract : The University Health Network has been awarded a contract to provide tumour types to the NCI for the Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of thyroid (80),cervical(21),uterine (22) and endometrioid (38)speci Health and Human Services, Department of / National Institutes of Health 9/21/2010
JOHNS HOPKINS UNIVERSITY, THE $139,974 Grant Trans-NIH Recovery Act Research Support: Over the last years we have characterized transcription factors IRF-5, studied the regulation of its expression, and its role in the innate antiviral response. We were the first and only group that cloned and comprehensively analyzed properties of human I Health and Human Services, Department of / National Institutes of Health 7/06/2010
FRED HUTCHINSON CANCER RESEARCH CENTER $149,945 Grant Trans-NIH Recovery Act Research Support: Building from the parent grant study, the immediate goal of this administrative supplement is to test national dissemination of an internet-based intervention to a national cohort of hematopoietic stem cell transplantation (HSCT) survivors. This project Health and Human Services, Department of / National Institutes of Health 8/19/2010
BOSTON MEDICAL CENTER CORPORATION $195,450 Grant Trans-NIH Recovery Act Research Support: Develops and pilot-tests a culturally-tailored, clinic-based weight management program to reduce obesity among postpartum African American Women. The program adapts a multi-session effective weight loss program demonstrating success with patients contendi Health and Human Services, Department of / National Institutes of Health 8/25/2010
BRIGHAM AND WOMEN'S HOSPITAL, INC., THE $418,983 Grant Trans-NIH Recovery Act Research Support: We propose the creation of the virtual Melvin First International Center for Innovative Air Disinfection Technology. The Center, based in Boston, with collaborating universities and agencies in the US and abroad (South Africa, initially), will provide an Health and Human Services, Department of / National Institutes of Health 9/27/2010
UNIVERSITY OF SOUTHERN CALIFORNIA $84,457 Grant Trans-NIH Recovery Act Research Support: Primate lentiviruses code for a conserved function that is necessary for the efficient production of viral particles and in vivo pathogenicity. For HIV-1 this is carried out by the accessory protein Vpu, while for HIV-2, the function has been mapped to th Health and Human Services, Department of / National Institutes of Health 8/16/2010
WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY $350,001 Grant Trans-NIH Recovery Act Research Support: Hox homeodomain transcription factors play essential roles in vertebrate limb patterning and morphogenesis, but the mechanisms of Hox regulation remain elusive at the molecular level. The Pbx1 TALE homeodomain protein is a homolog of Drosophila extradenti Health and Human Services, Department of / National Institutes of Health 8/25/2010
UNIVERSITY OF MARYLAND $422,176 Grant Trans-NIH Recovery Act Research Support: The immediate goal is to establish an active research program at UMES investigating herpesvirus biology. HSV ocular infection is the leading cause of corneal blindness in the industrialized world. Epidemiological data suggested that approximately 50,000 n Health and Human Services, Department of / National Institutes of Health 9/14/2010
TRUSTEES OF TUFTS COLLEGE INC $447,708 Grant Trans-NIH Recovery Act Research Support: Administrative Supplement in support of Comparative Effectiveness Research Workforce Development The proposed Web-based Comparative Effectiveness Research (CER) survey course will be a one credit (30 hour) course delivered in the Spring 2011 semeste Health and Human Services, Department of / National Institutes of Health 7/08/2010
UNIVERSITY OF WASHINGTON $227,675 Grant Trans-NIH Recovery Act Research Support: Twin studies have provided decisive evidence for the hereditary nature of body weight regulation, demonstrating that individual differences in tendencies toward weight gain could be explained by an interaction between genotype and the nutritional environm Health and Human Services, Department of / National Institutes of Health 7/19/2010
UNIVERSITY OF KENTUCKY $46,145 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Membrane fusion, a process critical for viral entry, is promoted by the paramyxovirus fusion (F) proteins. All F proteins contain a number of common features that play fundamental roles in fusion. However, significant Health and Human Services, Department of / National Institutes of Health 9/13/2010
CHILDREN'S HOSPITAL MEDICAL CENTER $108,724 Grant Trans-NIH Recovery Act Research Support: The main objectives of this supplemental funding is to test that FKBP52 and PRDX6 cooperatively direct an appropriate uterine environment for blastocyst implantation and pregnancy maintenance ant that FKBP52 has dual functions: first, FKBP52 optimizes PR Health and Human Services, Department of / National Institutes of Health 7/29/2010
UNIVERSITY OF TEXAS AT DALLAS $138,754 Grant Trans-NIH Recovery Act Research Support: Traumatic brain injury (TBI) is the number one cause of acquired long term disability with the highest rates occurring during adolescence. Despite evidence that higher order cognitive abilities may worsen or fail to adequately develop years after the brai Health and Human Services, Department of / National Institutes of Health 9/01/2010
RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA $64,759 Grant Trans-NIH Recovery Act Research Support: Mechanisms governing (a) normal gonadotropin-releasing hormone (GnRH) secretion across puberty and (b) abnormal GnRH secretion in peripubertal girls who go on to develop polycystic ovary syndrome (PCOS) are unclear. In the parent grant, we proposed a nove Health and Human Services, Department of / National Institutes of Health 7/19/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $2,363,388 Grant Trans-NIH Recovery Act Research Support: Chronic metabolic diseases, such as obesity, insulin resistance, type 2 diabetes, and cardiovascular disease are among the most common diseases with adverse effects on global health. Despite their enormous burden on human life, the preventive and therapeu Health and Human Services, Department of / National Institutes of Health 9/30/2010
UNIVERSITY OF CALIFORNIA, IRVINE $3,690,668 Contract : Normal fetal growth is a critical component of a healthy pregnancy and the long-term health of the offspring. Pivotal to understanding the dynamics of human fetal growth and to defining normal and abnormal fetal growth is the development of standards for Health and Human Services, Department of / National Institutes of Health 9/23/2010
UNIVERSITY OF CALIFORNIA, LOS ANGELES $64,956 Grant Trans-NIH Recovery Act Research Support: This administrative supplement application is submitted in response to NIH ARRA request for applications, and is part of the G?Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD)G?. One of the overall goals of the entire CIFASD is to det Health and Human Services, Department of / National Institutes of Health 9/03/2010
EMORY UNIVERSITY $78,517 Grant Trans-NIH Recovery Act Research Support: These are supplemental funds under the American Recovery and Reinvestment Act of 2009 (ARRA) for 1 UO1 AI077821-02. The parent grant supports investigators participating in the Clinical Trials in Organ Transplantation in Children (CTOTC)-02 multicenter tr Health and Human Services, Department of / National Institutes of Health 9/13/2010
WASHINGTON UNIVERSITY, THE $151,319 Grant Trans-NIH Recovery Act Research Support: Preterm birth is a major public-health issue because of its increasing incidence combined with the frequent occurrence of subsequent behavioral, neurological, and psychiatric challenges faced by surviving infants. Approximately 10-15% of very preterm chil Health and Human Services, Department of / National Institutes of Health 9/24/2010
UNIVERSITY OF UTAH, THE $834,912 Grant Trans-NIH Recovery Act Research Support: Neurodegenerative diseases represent an ever-increasing societal and economic burden with WHO estimates indicating that they will replace cancer as the 2nd leading cause of death by 2040. In neurodegenerative disease research, a wealth of pathways has bee Health and Human Services, Department of / National Institutes of Health 9/29/2010
LOUISIANA STATE UNIVERSITY SYSTEM $121,511 Grant Trans-NIH Recovery Act Research Support: Project proposed the following additional experiments that are closely related to the original Specific Aims of the original grant in order to expedite this work as follows: 1) To confirm the immunogenicity and protective efficacy of mucosal prime-boost Health and Human Services, Department of / National Institutes of Health 7/12/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $175,952 Grant Trans-NIH Recovery Act Research Support: We propose to expand the recruitment for the Epidemiology of H. pylori transmission to a second county facility in the Bay Area. Currently, we are recruiting predominantly at the refugee and, to a lesser degree, at the immunization clinic at Santa Clara Health and Human Services, Department of / National Institutes of Health 7/12/2010
UNIVERSITY OF NEVADA, RENO $177,028 Grant Trans-NIH Recovery Act Research Support: The purpose of this project is to use ultrasound techniques to non-invasively assess gastric motor function. By examining gastric wall motion using ultrasound over a short period of time (~ 5 minutes), it is possible to visualize abnormal patterns of mot Health and Human Services, Department of / National Institutes of Health 9/23/2010
UNIVERSITY OF MONTANA SYSTEM $1,005,100 Grant Trans-NIH Recovery Act Research Support: The goal of this project is to consolidate small molecule cores and new equipment, Nuclear Magnetic Resonance Spectrometer (NMR), within the Core Laboratory for Neuromolecular Production (CLNP) (P30NS055022) to produce a single, comprehensive and efficien Health and Human Services, Department of / National Institutes of Health 9/13/2010
MISSISSIPPI STATE UNIVERSITY $412,913 Grant Trans-NIH Recovery Act Research Support: This is one year challenge grant award from NIH/NIAID. This project began on 08/16/10 and ends on 08/15/11. This project proposes to develop a novel method in predicting influenza antigenic variants in silicon. Three specific aims were included: (1) Deve Health and Human Services, Department of / National Institutes of Health 8/16/2010
CHUGACH WORLD SERVICES, INC. $177,881 Contract : Prime Contract award HHSN292200900003I requires the Contractor to provide minor alteration construction and handy man services for the National Institutes of Health (NIH) located at the main campus located in Bethesda, Maryland and locations to include Po Health and Human Services, Department of / National Institutes of Health 9/27/2010
GRANT THORNTON LLP $1,527,972 Contract : Program Integrity Investigations to include a professional audit, program analysis, and other support services Health and Human Services, Department of / National Institutes of Health 9/28/2009
UNIVERSITY OF WISCONSIN SYSTEM $74,250 Grant Trans-NIH Recovery Act Research Support: The structure and function of synapses in Down syndrome (DS) brain are abnormal, causing the cognitive deficits that characterize this developmental disorder. Research within the last decade has revealed that, in addition to pre- and post-synaptic neurons Health and Human Services, Department of / National Institutes of Health 9/21/2010
CHILDREN'S HOSPITAL & RESEARCH CENTER $800,000 Grant Trans-NIH Recovery Act Research Support: The goal of proposed research is to use adenovirus gene transfer of specific apolipoprotein A-V (apoA-V) variants to elucidate the molecular basis of apoA-VG??s physiological effects on plasma triacylglycerol (TG). Knowledge gained from transgenic and kno Health and Human Services, Department of / National Institutes of Health 7/31/2009
UNIVERSITY OF CALIFORNIA, IRVINE $126,345 Grant Trans-NIH Recovery Act Research Support: This R01 revision application answers RFA NOT-OD-09-058 (Notice Title: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications). This is a revision application for the R01 grant GM076330, titled ?The Ketoreduction and Cy Health and Human Services, Department of / National Institutes of Health 8/27/2010
YALE UNIVERSITY $253,867 Grant Trans-NIH Recovery Act Research Support: The overall goals of this project are to define the common molecular mechanisms in the pathogenesis of biliary cirrhosis. Biliary cirrhosis accounts for approximately 20 percent of cases liver failure in adults and more than 50 percent of cases ofliver fa Health and Human Services, Department of / National Institutes of Health 7/15/2010
CORNELL UNIVERSITY, INC $163,161 Grant Trans-NIH Recovery Act Research Support: The purpose of this project is to examine the relationships between nonstandard work among mothers and children's behavior, cognitive test scores, and body mass index (BMI; or weight-for height). We focus on atypical and unpredictable aspects of maternal Health and Human Services, Department of / National Institutes of Health 7/21/2010
GEORGETOWN UNIVERSITY (THE) $149,346 Contract : The goal of this project is to develop a framework for automated parameter tuning of ITK non-rigid registration pipelines. ITK components used to construct registration pipelines are highly parameterized. As a consequence, the performance of a registratio Health and Human Services, Department of / National Institutes of Health 8/05/2010
WESTERN UNIVERSITY OF HEALTH SCIENCES $456,513 Grant Trans-NIH Recovery Act Research Support: This project studies accommodative function, the ability to focus while doing near work. Visual discomfort symptoms, such as headaches, sore eyes, and blurred vision are commonly associated with prolonged reading or other near work. Researchers have long Health and Human Services, Department of / National Institutes of Health 9/27/2010
UNIVERSITY OF ALABAMA AT BIRMINGHAM $2,708,560 Contract : ARRA - Systolic Blood Pressure Intervention Trial (SPRINT) - Senior Health and Human Services, Department of / National Institutes of Health 9/24/2010
UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE $131,258 Grant Trans-NIH Recovery Act Research Support: The Vermont IDeA Network for Biomedical Excellence is the Vermont Genetics Network (VGN). We build biomedical research capacity throughout the state by developing facilities such as for Microarray and Proteomics, providing Bioinformatics services, suppor Health and Human Services, Department of / National Institutes of Health 8/20/2010
JOHNS HOPKINS UNIVERSITY, THE $410,000 Grant Trans-NIH Recovery Act Research Support: Malaria is responsible for more mortality than any parasitic disease. Malaria parasite species that infect humans, must first take up residence in liver cells before invading red blood cells which instigates the pathology associated with malaria. We are s Health and Human Services, Department of / National Institutes of Health 8/02/2010
MASSACHUSETTS INSTITUTE OF TECHNOLOGY $124,676 Grant Trans-NIH Recovery Act Research Support: The broad, long-term objectives of the parent award for this supplement are to understand how proteins establish interaction specificity at the level of individual domains, and to capture this in models that can be used for computational prediction and de Health and Human Services, Department of / National Institutes of Health 9/30/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $231,149 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The last two decades mark a conceptual revolution in immune recognition, switching from one based on engagement of clonal receptor to one that integrates pattern recognition with clonal recognition. The pathogen-associ Health and Human Services, Department of / National Institutes of Health 7/19/2010
YALE UNIVERSITY $116,454 Grant Trans-NIH Recovery Act Research Support: Innate immunity via Toll Like Receptors (TLRs) is the first line of defense against microbial invasion and is essential for pathogen detection. Our preliminary data, using experimental murine systems, also demonstrates that TLR dependent immunity is impor Health and Human Services, Department of / National Institutes of Health 8/02/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $39,862 Grant Trans-NIH Recovery Act Research Support: The overall aim of this Mentored Research Scientist Career Development (K01) Award is for the candidate to gain new skills so that she may become an independent researcher in the area of neuroimaging, particularly with respect to understanding the neurobe Health and Human Services, Department of / National Institutes of Health 9/24/2010
UNIVERSITY OF WASHINGTON $201,376 Grant Trans-NIH Recovery Act Research Support: Reducing the disproportionate rates of HIV prevalence among persons of African descent in the U.S. is a critically important task. The parent grant and the supplement requested here are focused on that goal. The aim of the parent grant is to develop cul Health and Human Services, Department of / National Institutes of Health 7/29/2010
COPPER RIVER INFORMATION TECHNOLOGY, LLC $4,018,579 Contract : This contract is for the provision of computed tomography (CT) equipment. The contractor is charged to install the CT equipment, as well as provide turn-key planning, design, and build services. Health and Human Services, Department of / National Institutes of Health 8/06/2010
ZANTECH IT SERVICES, INC. $827,944 Contract : Service Oriented Architecture (SOA) Program Management / Support Services Health and Human Services, Department of / National Institutes of Health 1/27/2010
NORTHWESTERN UNIVERSITY $86,757 Grant Trans-NIH Recovery Act Research Support: The proposal is a response for a research project (cooperative agreement) by the NIH-NIDDK for consideration for one of 10 Clinical Evaluation and Treatment Centers (CETC) forming a consortium to develop and conduct a randomized placebo controlled trial t Health and Human Services, Department of / National Institutes of Health 9/30/2010
REGENTS OF THE UNIVERSITY OF MINNESOTA $1,362,891 Grant Trans-NIH Recovery Act Research Support: This proposal builds and expands on completed and ongoing biomarker work in SMART and ESPRIT. We have formulated 7 aims, and each takes advantage of stored specimens in the INSIGHT repository. Serious non-AIDS conditions are a major focus of our resear Health and Human Services, Department of / National Institutes of Health 8/16/2010
MOUNT SINAI SCHOOL OF MEDICINE $423,750 Grant Trans-NIH Recovery Act Research Support: We have recently identified osteopontin as a key protein involved in the pathogenesis of liver fibrosis. The work proposed herein will clarify the mechanism whereby osteopontin modulates oval cell expansion, ductular reaction, and collagen I increase; thu Health and Human Services, Department of / National Institutes of Health 7/15/2010
ALCHEM LABORATORIES CORP $300,000 Contract : Synthesis of known drug candidates as specified in ARRA project 'Cancer Pathway Dissection and Combination Therapies' Health and Human Services, Department of / National Institutes of Health 8/25/2010
WASHINGTON UNIVERSITY, THE $2,489,728 Grant Trans-NIH Recovery Act Research Support: WASHINGTON UNIVERSITY CER MENTORED CAREER DEVELOPMENT AWARD KM1 The PI wishes to use the existing abstract as reported in the NIH reporter as her Award Description for ARRA reporting purposes. Health and Human Services, Department of / National Institutes of Health 9/28/2010
UNIVERSITY OF IOWA, THE $172,711 Grant Trans-NIH Recovery Act Research Support: Cocaine addiction is a serious problem afflicting the United States, and treatment remains imperfect. Although the study of cocaine self-administration and reinstatement in rats has provided much knowledge of cocaine addiction, relatively few studies have Health and Human Services, Department of / National Institutes of Health 7/10/2010
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $93,468 Grant Trans-NIH Recovery Act Research Support: The long-term objective of this proposal is to advance research in the area of physical activity promotion for persons with multiple sclerosis (MS) by implementing and evaluating a multifaceted intervention that can be translated into public health and re Health and Human Services, Department of / National Institutes of Health 9/13/2010
DUKE UNIVERSITY $144,321 Grant Trans-NIH Recovery Act Research Support: Cryptococcus neoformans is one of the most common life-threatening central nervous system infections in humans and despite present treatments, morbidity and mortality still remain high. In a recent outbreak on Vancouver Island, British Columbia it was sho Health and Human Services, Department of / National Institutes of Health 7/06/2010
STARKS ASSOCIATES, INC. $479,000 Contract : This contract action provides compound synthesis support for the NCI American Recovery and Reinvestment Act (ARRA) project entitled Cancer Pathway Dissection and Combination Therapies project. The NCI wishes to build a specific targeted library or librar Health and Human Services, Department of / National Institutes of Health 8/03/2010
WASHINGTON UNIVERSITY, THE $50,008 Grant Trans-NIH Recovery Act Research Support: The long-term goal of this project is to fully characterize the mechanisms by which neutrophil serine proteases regulate the inflammatory response. We hope that information gained from these studies can be used to develop strategies to inhibit the activit Health and Human Services, Department of / National Institutes of Health 9/29/2010
VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY $240,733 Grant Trans-NIH Recovery Act Research Support: Synapses in the cerebral cortex undergo dynamic alterations in their efficiency throughout life. In particular, the neurons of the primary visual cortex can use such synaptic plasticity to perform parallel computations on aspects of visual processing. Suc Health and Human Services, Department of / National Institutes of Health 9/21/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $203,673 Grant Trans-NIH Recovery Act Research Support: Autoimmune diabetes is characterized by an inflammatory reaction in and around pancreatic islets, followed by selective destruction of ?-cells. The broad goals of this research are to elucidate the cellular mechanisms that are responsible for pancreatic ? Health and Human Services, Department of / National Institutes of Health 7/15/2010
NEW YORK UNIVERSITY (INC) $357,647 Grant Trans-NIH Recovery Act Research Support: Goal of the parent application: The Conte Center for Schizophrenia Research focuses on mechanisms underlying cognitive dysfunction in schizophrenia, with particular emphasis on contributions of early sensory dysfunction to higher order cognitive deficits. Health and Human Services, Department of / National Institutes of Health 5/22/2010
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE $11,000 Grant Trans-NIH Recovery Act Research Support: Cholesterol is a critical nutrient that is required as a structural component of cell membranes and is a precursor in the biosynthesis of steroid hormones and bile acids. It is important that cholesterol levels are properly regulated because aberrant meta Health and Human Services, Department of / National Institutes of Health 9/29/2010
UNIVERSITY OF MAINE SYSTEM $101,209 Grant Trans-NIH Recovery Act Research Support: Attachment of muscle fibers to the basement membrane (BM) is necessary for musculoskeletal function. Mutations in genes that inactivate proteins required for adhesion to the BM lead to multiple myopathies such as Duchenne muscular dystrophy, Becker muscul Health and Human Services, Department of / National Institutes of Health 7/10/2010
THE GEORGE WASHINGTON UNIVERSITY $328,650 Grant Trans-NIH Recovery Act Research Support: Forebrain neural stem cell specification remains poorly understood, even though radial gliaG??the fate-specified neural stem cells of the forebrainG??give rise to neurons and glia that constitute circuits essential for cognition, learning and memory. The Health and Human Services, Department of / National Institutes of Health 9/02/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $998,697 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): There is extensive research evidence that stressors in the social and physical environment are associated with poor health outcomes, and that these conditions contribute to ethnic, racial and socioeconomic health dispa Health and Human Services, Department of / National Institutes of Health 7/06/2010
CARL ZEISS MICROIMAGING, LLC $227,000 Contract : Laboratory Equipment, microscope system. Health and Human Services, Department of / National Institutes of Health 7/12/2010
DUKE UNIVERSITY $1,000,000 Grant Trans-NIH Recovery Act Research Support: The goal of this project is to establish an effective, practical, and widely available medical countermeasure to mitigate radiation-induced lung injury by utilizing metalloporphyrin antioxidant mimetic based strategies. This project is strongly focused on Health and Human Services, Department of / National Institutes of Health 8/09/2010
SAINT LOUIS UNIVERSITY $221,250 Grant Trans-NIH Recovery Act Research Support: The proposed experiments will elucidate mechanisms involved in development and differentiation of a highly specialized neuronal epithelial cell type: the rod photoreceptor cell. The rd1 mouse model of juvenile retinitis pigmentosa will be used to gain ins Health and Human Services, Department of / National Institutes of Health 7/08/2010
RADIATION MONITORING DEVICES, INC. $656,503 Grant Trans-NIH Recovery Act Research Support: SBIR award, year 2 funding for project entitled High Performance Transparent Optical Ceramic Scintillators through Technology. Public Health Relevance: The proposed research will investigate a promising detector technology which should have a major impac Health and Human Services, Department of / National Institutes of Health 8/05/2010
UNIVERSITY OF UTAH, THE $220,094 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This Competitive Revision is in response to Notice Number NOT-OD-10-032 with Notice Title: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications (R01, R03, R15, R21, R21/33 and R37) Health and Human Services, Department of / National Institutes of Health 9/20/2010
TRUSTEES OF INDIANA UNIVERSITY $397,906 Grant Trans-NIH Recovery Act Research Support: Type 1 diabetes has typically been considered a T cell mediated autoimmune diseases. The recently reported, TrialNet-sponsored study using the monoclonal antibody rituximab (anti-CD20) demonstrated that B cells also play a role in the pathogenesis. Specif Health and Human Services, Department of / National Institutes of Health 9/30/2010
NORTH DAKOTA STATE UNIVERSITY $238,559 Grant Trans-NIH Recovery Act Research Support: The project seeks to provide Dr. Blakeslee with the opportunity to master skills to enable her to integrate high-density EEG methods to her ongoing studies of the neural bases for visual perception. Dr. Rainville will receive training in the laboratory of Health and Human Services, Department of / National Institutes of Health 9/23/2010
MCLAUGHLIN RESEARCH INSTITUTE FOR BIOMEDICAL SCIENCES, INC. $374,805 Grant Trans-NIH Recovery Act Research Support: The award grants McLaughlin Research Institute for Biomedical Sciences, Inc. funds with which to acquire an Olympus FV1000 Spectral Confocal with IX81 inverted microscope and accessories. The microscope will allow imaging of peripheral nerve sections, tea Health and Human Services, Department of / National Institutes of Health 8/05/2010
UNIVERSITY OF FLORIDA $81,250 Contract : The University of Florida has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of liver cases. These cases are all primary and untreated. The collecti Health and Human Services, Department of / National Institutes of Health 9/21/2010
JEOL USA, INC. $600,000 Contract : Provide electron microscope including Delivery, set up, installation, performance of accptance tests and user training at the NIH site. One year parts and labor is included. Health and Human Services, Department of / National Institutes of Health 7/19/2010
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. $471,671 Grant Trans-NIH Recovery Act Research Support: Heterochromatin formation is essential for chromosome segregation, epigenetic silencing and X chromosome inactivation. In spite of their biological significance, the mechanisms involved in the establishment of heterochromatin domains during oogenesis are Health and Human Services, Department of / National Institutes of Health 9/01/2010
MELANOMA INSTITUTE AUSTRALIA $162,500 Contract : The Melanoma Institute of Australia has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of metastatic melanoma tissue (100 cases). These cases are all Health and Human Services, Department of / National Institutes of Health 9/03/2010
BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON $441,361 Grant Trans-NIH Recovery Act Research Support: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the USA and may be present in up to 20% of the general population. A subset of patients with NAFLD has non-alcoholic steatohepatitis (NASH), a more severe for of this disease a Health and Human Services, Department of / National Institutes of Health 7/27/2010
UNIVERSITY OF FLORIDA $271,026 Grant Trans-NIH Recovery Act Research Support: The long rand goal is to provide intervention to delay or prevent cognitive decline associated with unsuccessful aging, in order to improve the health and well-being of older Americans. The incidence of Alzheimer's disease (AD) is projected to increase d Health and Human Services, Department of / National Institutes of Health 9/14/2010
YALE UNIVERSITY $35,583 Grant Trans-NIH Recovery Act Research Support: Implanting human cytotrophoblasts (CTBs) invade an underlying decidua comprised of decidual cells and such immune cells as macrophages (MFs) and dendritic cells (DCs). These specialized antigen-presenting cells (APCs) mediate innate immunity, subsequent a Health and Human Services, Department of / National Institutes of Health 6/15/2010
UNIVERSITY OF CALIFORNIA, DAVIS $85,000 Grant Trans-NIH Recovery Act Research Support: The award is for the purchase of a flow cytometer to support and accelerate our studies on the fundamental mechanisms of phagocytosis. Combining flow cytometry measurements with the unique single-cell tests pioneered by our laboratory allows us, for exam Health and Human Services, Department of / National Institutes of Health 7/26/2010
NORTHWESTERN UNIVERSITY $2,522,391 Grant Trans-NIH Recovery Act Research Support: The broad, long-term objective of this proposal is to improve he detection and treatment for patients suffering from various diseases in the neurological, cardiovascular, or body systems. Investigators at the Northwestern University Feinberg School of Med Health and Human Services, Department of / National Institutes of Health 7/01/2010
MASSACHUSETTS INSTITUTE OF TECHNOLOGY $372,834 Grant Trans-NIH Recovery Act Research Support: Our goal is to test the expression output of tens of thousands of candidate enhancers in a single experiment. This can be of great use in testing predicted candidate enhancers across the genome arising from our chromatin work in the context of ENCODE and Health and Human Services, Department of / National Institutes of Health 8/06/2010
YALE UNIVERSITY $415,650 Grant Trans-NIH Recovery Act Research Support: As requested by RFA-HD-04-002 entitled 'Genomic and Proteomic Network for Premature Birth Research,' we propose to establish a Data Management, Statistics, and Informatics Core at Yale University as a part of the Network. We will be responsible for the ce Health and Human Services, Department of / National Institutes of Health 9/22/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $646,000 Grant Trans-NIH Recovery Act Research Support: A Grand Opportunity for scientific advance has been created by the confluence of falling costs of genotyping, the development of statistical methods for genome-wide association studies (GWAS), and the creation of a substantial repository of genetic materi Health and Human Services, Department of / National Institutes of Health 9/29/2009
DUKE UNIVERSITY $2,433,915 Grant Trans-NIH Recovery Act Research Support: We propose an interdisciplinary CER KM1 training program, focused on Biostatistics, Cancer, and Cardiology that matches mentors from diverse CER methodological backgrounds with mentees committed to a career in CER. A leadership team of experienced Duke CE Health and Human Services, Department of / National Institutes of Health 9/28/2010
TRUSTEES OF BOSTON UNIVERSITY $310,687 Grant Trans-NIH Recovery Act Research Support: Tumor metastasis, a process by which tumor cells migrate from the primary tumor to distant locations in the body, is the main cause of cancer related deaths. Through a combination of computer models and high resolution microscopy the project carried out u Health and Human Services, Department of / National Institutes of Health 9/01/2010
EMORY UNIVERSITY $441,691 Grant Trans-NIH Recovery Act Research Support: The project is entitled 'Accessible Handling of Misclassified or Missing Binary Variables in CER Studies'. The goal of this project is to provide statistical methods to aid comparative effectiveness research (CER) investigators with common problems encoun Health and Human Services, Department of / National Institutes of Health 9/24/2010
UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC. $355,610 Grant Trans-NIH Recovery Act Research Support: 1. To determine the mechanism by which radiation affects CUGBP2 expression. In this regard, we have cloned a 2 kb region of COX-2 promoter and are currently almost completely cloned deletion mutants into the plasmid PCL3-Basic, upstram of the luciferase r Health and Human Services, Department of / National Institutes of Health 9/16/2010
UNIVERSITY OF WASHINGTON $206,220 Grant Trans-NIH Recovery Act Research Support: The parent grant is a randomized controlled trial evaluating the efficacy of a telephone-delivered cognitive behavioral therapy pain intervention relative to telephone-delivered pain education intervention in a sample of adults with chronic pain and eithe Health and Human Services, Department of / National Institutes of Health 9/13/2010
BAYLOR COLLEGE OF MEDICINE $132,730 Grant Trans-NIH Recovery Act Research Support: The main purpose of this supplement were to save jobs and supplement unanticipated expansion. Abstract: The parent grant is focused on the role of the transcription factors ELF4 and KLF4 on the development and maintenance of CD8+ T cell memory. In this su Health and Human Services, Department of / National Institutes of Health 7/09/2010
FRED HUTCHINSON CANCER RESEARCH CENTER $550,000 Contract : In keeping with the Interagency Agreement between the Centers for Disease Control and Prevention and the National Cancer Institute, funds have been allocated to this contract to enhance access to and utilization of Quitline services. The NCI?s Smoking Qu Health and Human Services, Department of / National Institutes of Health 9/29/2010
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY $300,216 Contract : RECOVERY: Computational Thinking to Support Clinicians and Biomedical Scientists. Health and Human Services, Department of / National Institutes of Health 9/24/2010
UNIVERSITY OF TEXAS AT SAN ANTONIO $132,742 Grant Trans-NIH Recovery Act Research Support: There currently is no licensed vaccine against Chlamydia trachomatis, the leading cause of bacterial sexually transmitted disease worldwide. Untreated genital chlamydial infection cause serious sequelae such as pelvic inflammatory disease, ectopic pregnan Health and Human Services, Department of / National Institutes of Health 9/07/2010
UNIVERSITY OF DELAWARE $100,000 Grant Trans-NIH Recovery Act Research Support: Robotic Exoskeletons, FES, and Biomechanics: Treating Movement Disorders. The goal of this ARRA research supplement are as follows: (i) Design and fabricate a bilateral exoskeleton ALEX III, worn in both legs, which can perform the following functions: Health and Human Services, Department of / National Institutes of Health 9/01/2010
CARNEGIE MELLON UNIVERSITY $149,549 Contract : METHODS IN MEDICAL IMAGE ANALYSIS: AN ITK-BASED COURSE WITH DELIVERABLE ALGORITHMS THAT EXTENDS AND EVALUATES ITK WHILE BROADENING ITS DEVLOPER BASE: The primary objective is to adapt an existing multi-university ITK-project-based course, titled G?Method Health and Human Services, Department of / National Institutes of Health 8/05/2010
UNIVERSITY OF MIAMI $227,994 Grant Trans-NIH Recovery Act Research Support: There are over 3.2 - 4.7 million people in the US suffering from dry eye syndrome (DES) by middle age. DES is a common multi-factorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear film instab Health and Human Services, Department of / National Institutes of Health 8/31/2010
REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE $70,000 Grant Trans-NIH Recovery Act Research Support: The purpose of this award is to replace aging/malfunctioning equipment necessary for the completion of project aims as outlines in my ongoing NIGMS award, GM071747. Health and Human Services, Department of / National Institutes of Health 8/25/2010
LIFE TECHNOLOGIES CORPORATION $94,942 Contract : Qty. 216 CAT. #11304029-PLATINUM TAQ HIGH FIDELITY Shipping and Handling Charges Health and Human Services, Department of / National Institutes of Health 9/24/2010
RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA $148,204 Grant Trans-NIH Recovery Act Research Support: For children between the ages of 3 and 5, their readiness to function competently in school is best understood in terms of the nature and quality of their interactions in classrooms with adults, with peers, and with learning/instructional activities. Clas Health and Human Services, Department of / National Institutes of Health 8/10/2010
UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO $591,627 Grant Trans-NIH Recovery Act Research Support: The San Antonio Sexually Transmitted Infections & Topical Microbicides Cooperative Research Center (STI TM CRC) proposal represents an integrative, collaborative and innovative multi-disciplinary research effort to investigate and prevent important emergi Health and Human Services, Department of / National Institutes of Health 9/07/2010
YALE UNIVERSITY $124,375 Contract : The Yale University has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of melanoma cases. These cases are all primary and untreated. The collection Health and Human Services, Department of / National Institutes of Health 5/04/2010
UNIVERSITY OF SOUTH FLORIDA $220,500 Grant Trans-NIH Recovery Act Research Support: Angelman Syndrome (AS) is a genetic neurological disorder that presents with seizure, ataxia, severe mental retardation, virtual absence of speech, and is genetically and biochemically associated with our cognitive disorders, such as autism and Rettsyndro Health and Human Services, Department of / National Institutes of Health 9/23/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $399,611 Grant Trans-NIH Recovery Act Research Support: We propose to develop and maintain a Data Coordinating Center (DCC) that will provide support for a network of clinical sites studying chronic pediatric liver disease. Specifically we will continue, expand, and merge the efforts of investigators from the Health and Human Services, Department of / National Institutes of Health 8/05/2010
OREGON SOCIAL LEARNING CENTER $369,620 Grant Trans-NIH Recovery Act Research Support: Mentoring is widely viewed as an effective preventive intervention for a variety of youth problems and consequences, including conduct disorder and delinquency, academic failure and school drop out, substance use and abuse, and early sexual behavior and t Health and Human Services, Department of / National Institutes of Health 9/01/2010
CASE WESTERN RESERVE UNIVERSITY $982,989 Grant Trans-NIH Recovery Act Research Support: The grant entitled Therm Electron LTQ Orbitrap XL will enhance mass spectrometry capability and research throughput of the Center for Proteomics and Bioinformatics (CPB) at Case Western Reserve University. The user group supported by this Center is growin Health and Human Services, Department of / National Institutes of Health 7/08/2010
AKONNI BIOSYSTEMS INC. $2,985,932 Grant Trans-NIH Recovery Act Research Support: Mycobacterium tuberculosis (TB) infects approximately one-third of the worldG??s population, with approximately nine million new cases of TB occurring each year and two million deaths attributable to the disease. Culture-based methods remain the gold sta Health and Human Services, Department of / National Institutes of Health 9/20/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $531,773 Grant Trans-NIH Recovery Act Research Support: This ARRA supplement is a substudy of !Colorectal Chemoprevention with Calcium and Vitamin D,! a randomized, double-blind placebo controlled study testing whether supplementation with calcium (1200 mg per day) and/or vitamin D (1000 IU per day) decreases Health and Human Services, Department of / National Institutes of Health 9/16/2010
UNIVERSITY OF WISCONSIN SYSTEM $1,999,793 Grant Trans-NIH Recovery Act Research Support: Dr. Mary (Molly) Carnes at the University of Wisconsin-Madison is an ideal candidate for the Pathfinder Award. Her innovative research has already led to changes in practices that promote workforce diversity in science, technology, engineering, mathemati Health and Human Services, Department of / National Institutes of Health 9/30/2010
SAMUEL MERRITT UNIVERSITY $413,013 Grant Trans-NIH Recovery Act Research Support: Multiple sclerosis (MS) is a neurodegenerative disease affecting approximately 2.5 million people worldwide and is the most frequent cause of disability in young adults. Balance and gait impairments are common in MS, however, the manifestation of balance Health and Human Services, Department of / National Institutes of Health 9/20/2010
UNIVERSITY OF WASHINGTON $99,275 Grant Trans-NIH Recovery Act Research Support: Our parent grant (#U01HD060488-01, 'BDADs for Male Contraception') hypothesized that BDADs such as WIN 18,446 inhibit spermatogenesis by inhibiting the testicular enzyme ALHD1a2, which converts retinal to retinoic acid. Work in our cell-based ALDH1a2 as Health and Human Services, Department of / National Institutes of Health 7/19/2010
MOLECULAR INSIGHT PHARMACEUTICALS, INC. $243,101 Grant Trans-NIH Recovery Act Research Support: Determination of serum prostate specific antigen (PSA) is an effective early screen for potential Prostate cancer with revenues estimated at over $350 million annually. Although the current screening method of PSA levels in the blood is valuable for early Health and Human Services, Department of / National Institutes of Health 9/01/2010
MAYO CLINIC $668,560 Grant Trans-NIH Recovery Act Research Support: Barrett's esophagus (BE), a well-known complication of GER, is the strongest known precursor of esophageal adenocarcinoma (EAC). Thus, identifying effective screening approaches for the early detection of BE are highly desired. Current impediments to BE s Health and Human Services, Department of / National Institutes of Health 9/30/2010
INTELLIGENT OPTICAL SYSTEMS, INC. $199,961 Grant Trans-NIH Recovery Act Research Support: Intelligent Optical Systems (IOS) proposes to accelerate the commercialization of a simple to use, point of care clinical assay system that can be used for the early screening of ovarian and other cancers as well as for a wide range of other diagnostic te Health and Human Services, Department of / National Institutes of Health 9/29/2009
BATTELLE MEMORIAL INSTITUTE $3,246,135 Contract : The objective of this contract is to establish a Quality Management System (QMS) across the funded activities of The Cancer Genome Atlas (TCGA) program, with the goal of identifying non-conforming data in a timely fashion to ensure data released to the pu Health and Human Services, Department of / National Institutes of Health 9/24/2010
LOYOLA UNIVERSITY $49,847 Grant Trans-NIH Recovery Act Research Support: The purpose of this supplemental award is to allow us to purchase key pieces of equipment and enable us to continue to explore mechanisms by which acute/binge alcohol exposure results in alterations in innate immune responses after burn injury. Health and Human Services, Department of / National Institutes of Health 8/19/2010
REGENTS OF THE UNIVERSITY OF MINNESOTA $73,136 Grant Trans-NIH Recovery Act Research Support: Insufficient copper (Cu) during perinatal development of rodents has a major impact on the central nervous system leading to altered neurochemistry and behavior even after long-term Cu repletion. Human intakes of Cu during pregnancy and lactation may be s Health and Human Services, Department of / National Institutes of Health 7/21/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $49,730 Grant Trans-NIH Recovery Act Research Support: The Partners Human Research Committees (IRBs) in Boston MA provides ethical and scientific review of clinical research projects conducted primarily at Massachusetts General Hospital and Brigham and WomenG??s Hospital, and also at affiliated institutions c Health and Human Services, Department of / National Institutes of Health 9/25/2010
UNIVERSITY OF CALGARY $58,695 Contract : The University of Calgary has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of liver/pancreatic cases. These cases are all primary and untreated. T Health and Human Services, Department of / National Institutes of Health 9/27/2010
WASHINGTON UNIVERSITY, THE $106,568 Grant Trans-NIH Recovery Act Research Support: The purpose of this Administrative Supplement is to explore a new therapeutic target for globoid cell leukodystrophy (GLD) that was discovered during our NIH-funded research and accelerate the translation of these approaches into the clinic. Consistent w Health and Human Services, Department of / National Institutes of Health 7/08/2010
UNIVERSITY OF FLORIDA $240,437 Grant Trans-NIH Recovery Act Research Support: The regulation of actin filament dynamics in neutrophils and macrophages allows cells to crawl to sites of infection and ingest invading pathogens. The present grant focuses on the most abundant actin regulatory protein in macrophages, CapG. Aim 1 will ex Health and Human Services, Department of / National Institutes of Health 7/12/2010
COLORADO STATE UNIVERSITY $1,958,105 Grant Trans-NIH Recovery Act Research Support: The long term goal of our program is to develop novel broad spectrum chemotherapeutics that can be used for Phase 1 clinical trials for treating the diseases caused by priority pathogens such as Francisella tularensis, Burkholderia pseudomallei and Yersin Health and Human Services, Department of / National Institutes of Health 8/30/2010
TRUSTEES OF DARTMOUTH COLLEGE $237,000 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The overall goal of the proposed studies in this R21 application is a better understanding of the molecular and cellular mechanisms by which aldosterone regulates sodium homeostasis. Studies by others and us reveale Health and Human Services, Department of / National Institutes of Health 7/15/2010
RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE $110,919 Grant Trans-NIH Recovery Act Research Support: Efficacy of Various Positive Reinforcers in the Treatment of Destructive Behavior Destructive behavior (e.g., self-injury, aggression) may impede the development of many individuals with disabilities. These behaviors may occur for many reasons however, fo Health and Human Services, Department of / National Institutes of Health 7/16/2010
CHILDREN'S HOSPITAL & RESEARCH CENTER $397,318 Grant Trans-NIH Recovery Act Research Support: This one-year R56 project will focus on the genotyping of subsets of a very large mapping population of an N2F1 C57BL/6N x 129P2 mouse intercross that was phenotyped for metabolic disease traits including body composition by DEXA, body weights, and glucos Health and Human Services, Department of / National Institutes of Health 7/12/2010
MASSACHUSETTS INSTITUTE OF TECHNOLOGY $499,106 Grant Trans-NIH Recovery Act Research Support: We propose to conduct high-throughput sequencing of cDNAs using a strand-specific, paired-end version of the Illumina mRNA-Seq protocol from a total of 10 specific tissues (cerebral corex, heart, liver, skeletal muscle, testis, spleen, cerebellum, colon, Health and Human Services, Department of / National Institutes of Health 8/12/2010
UNIVERSITY OF ALABAMA AT BIRMINGHAM $471,384 Grant Trans-NIH Recovery Act Research Support: LKB1 (liver kinase B1) is a serine/threonine kinase that is mutationally inactivated in Peutz-Jeghers syndrome and many cancers. It is estimated that 93% of PJS patients will develop a malignant tumor at an average age of 43 years. LKB1 mutations have als Health and Human Services, Department of / National Institutes of Health 6/17/2010
CORNELL UNIVERSITY, INC $238,500 Grant Trans-NIH Recovery Act Research Support: This proposal is to conduct basic research into the structure and function of mammalian cells, with a focus on the processes of secretion and endocytosis. Both secretion and endocytosis are vital for human and animal health because they are required for m Health and Human Services, Department of / National Institutes of Health 7/19/2010
YALE UNIVERSITY $413,275 Grant Trans-NIH Recovery Act Research Support: The transcription states of genes are either stable or flexible, which has clear biological importance. Also, evidence is mounting that exogenous insults acting on fetus can cause irreversible damages to chromatin (called epimutations), impairing gene fun Health and Human Services, Department of / National Institutes of Health 7/21/2010
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $1,627,009 Contract : We have been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically to establish a Tissue Source Site (TSS) Network capable of delivering clinically annotated biospecimens through either or both retr Health and Human Services, Department of / National Institutes of Health 9/27/2010
MOUNT SINAI SCHOOL OF MEDICINE $127,867 Grant Trans-NIH Recovery Act Research Support: Dengue virus (DenV) is a devastating human pathogen that causes disease and viremia in millions of people worldwide every year. But very little is known about the initiation of immunity by DenV. In this proposal we will study the following aims: Aim 1. Wh Health and Human Services, Department of / National Institutes of Health 8/30/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $516,000 Grant Trans-NIH Recovery Act Research Support: Capitalizing on our group's experience on single molecule enzymology, we propose a novel method for multiplex sequencing of individual nucleic acid molecules using a sequencing-by-synthesis approach that employs fluorogenic nucleotide substrates. Upon inc Health and Human Services, Department of / National Institutes of Health 9/16/2010
OREGON HEALTH & SCIENCE UNIVERSITY $996,212 Grant Trans-NIH Recovery Act Research Support: In this application, we describe a new community partnership entitled Collaborative Research Efforts Aimed at Translating Evidence and building Community Capacity (CREATE Community Capacity). The Oregon Health & Science University (OHSU) and OCHIN (a com Health and Human Services, Department of / National Institutes of Health 9/20/2010
SOCIAL & SCIENTIFIC SYSTEMS, INC. $350,901 Grant Trans-NIH Recovery Act Research Support: This award is an administrative supplement for the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Group, specifically, it provides supplemental funding for the HIV-1 Infection & Transmission Project. Health and Human Services, Department of / National Institutes of Health 9/27/2010
YALE UNIVERSITY $9,197,360 Grant Trans-NIH Recovery Act Research Support: This application requests funding to renovate the animal facility in a newly acquired Yale research complex that was purchased from Bayer in 2007. The animal facility was used by Bayer for a combination of large animal and rodent studies and has been vaca Health and Human Services, Department of / National Institutes of Health 9/23/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $368,861 Grant Trans-NIH Recovery Act Research Support: We are actively investigating the role of a zinc finger transcription factor called ZBP-89 in the regulation of cell growth. This factor was expression cloned in my lab using a DNA element from the gastrin promoter that mediates EGF regulation. Recent stu Health and Human Services, Department of / National Institutes of Health 7/28/2010
UNIVERSITY OF ROCHESTER $986,900 Grant Trans-NIH Recovery Act Research Support: In accord with the goals and strategic vision of the Center, the Career Development Program (CDP) has three major goals. These include: 1) successful mentoring and career development of junior faculty; 2) recruitment and mentoring of investigators new Health and Human Services, Department of / National Institutes of Health 9/27/2010
UNIVERSITY OF TEXAS M D ANDERSON $48,141 Contract : The MD Anderson Cancer Center has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of endometrial cases. These cases are all primary and untreated. Th Health and Human Services, Department of / National Institutes of Health 9/21/2010
WAKE FOREST UNIVERSITY $55,167 Grant Trans-NIH Recovery Act Research Support: Intrauterine complications (i.e, perinatal asphyxia, prenatal immune activation and cesarean delivery) are a recognized risk factor for the emergence of later neuropsychiatric disorders. These disorders are characterized by hyperdopaminergic function, and Health and Human Services, Department of / National Institutes of Health 7/21/2010
UNIVERSITY OF MIAMI $77,387 Grant Trans-NIH Recovery Act Research Support: The purpose of the award is to understand the mechanisms by which a certain categories of proteins (known as DEAD-box helicases) regulate molecular processes inside the cell. These studies are being conducted in bacteria, which contain the same class of p Health and Human Services, Department of / National Institutes of Health 8/20/2010
UNIVERSITY OF IOWA, THE $225,000 Grant Trans-NIH Recovery Act Research Support: Refactoring the ITK FEM Framework Health and Human Services, Department of / National Institutes of Health 6/21/2010
UNIVERSITY OF CALIFORNIA, LOS ANGELES $147,001 Grant Trans-NIH Recovery Act Research Support: The project 'Valid Inference for Respondent Driven Sampling of Hidden Networked Populations' is to develop statistical methods for improving estimation in Respondent Driven Sampling (RDS) with a focus on developing tools and methods that will help, and be Health and Human Services, Department of / National Institutes of Health 8/18/2010
OREGON HEALTH & SCIENCE UNIVERSITY $49,999 Grant Trans-NIH Recovery Act Research Support: Our goal is to understand how the immune system recognizes and initiates its attack on solid organ transplants. Our preliminary date indicate that there may be a division of labor in the T cell response to allogeneic heart transplants. In mice maintaine Health and Human Services, Department of / National Institutes of Health 8/02/2010
UNIVERSITY OF CALIFORNIA, LOS ANGELES $757,000 Grant Trans-NIH Recovery Act Research Support: This is an administrative supplement to an NINDS Center Core Grant, the UCLA Informatics Center for Neurogenetics and Neurogenomics (ICNN), which provides informatics services that enable neuroscientists -- primarily investigators on designated NINDS fund Health and Human Services, Department of / National Institutes of Health 9/13/2010
BROAD INSTITUTE, INC., THE $30,965,067 Contract : This contract was awarded on September 24, 2010. We are providing second generation sequencing of tumor samples across numerous tumor types in support of The Cancer Genome Atlas (TCGA) project. In additional validation sequencing on mutations is also pe Health and Human Services, Department of / National Institutes of Health 9/24/2010
UNIVERSITY OF MARYLAND $47,775 Grant Trans-NIH Recovery Act Research Support: Bioterrorism is no longer a threat in the United States, but a reality. In 2001, the spread of anthrax spores through the U.S. mail illustrated that deadly agents can be acquired and spread using relatively unsophisticated means. It also highlighted our v Health and Human Services, Department of / National Institutes of Health 8/23/2010
BAYLOR COLLEGE OF MEDICINE $32,793 Grant Trans-NIH Recovery Act Research Support: This supplement is requesting funding from the American Recovery and Reinvestment Act of 2009 to accelerate the pace of its research. This grant is in its second year of funding and has been highly productive. During the first year of research funded by R Health and Human Services, Department of / National Institutes of Health 7/29/2010
REGENTS OF THE UNIVERSITY OF MINNESOTA $218,850 Grant Trans-NIH Recovery Act Research Support: This award funds our research looking at the role of hepatic adipose triglyceride lipase (ATGL) in liver energy metabolism and function. Health and Human Services, Department of / National Institutes of Health 7/09/2010
BRIGHAM AND WOMEN'S HOSPITAL, INC., THE $255,938 Contract : Brigham & Women's Hospital has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of clear cell renal tissues (150 cases). These cases are all primary and Health and Human Services, Department of / National Institutes of Health 6/23/2010
UNIVERSITY OF NEBRASKA $297,000 Grant Trans-NIH Recovery Act Research Support: Methicillin-resistant Staphylococcus aureus (MRSA), with various difficult-to-kill strains isolated clinically and from communities, caused 94,360 serious infections and 18,650 deaths in the United States in 2005. To tackle this problem, we propose to eng Health and Human Services, Department of / National Institutes of Health 8/16/2010
YALE UNIVERSITY $963,916 Grant Trans-NIH Recovery Act Research Support: The application addresses broad challenge area Model organisms for social behavior studies: Identification and development of model organisms that allow for integrative analyses of the genetic, biochemical, physiological, and environmental components of s Health and Human Services, Department of / National Institutes of Health 9/16/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $382,500 Grant Trans-NIH Recovery Act Research Support: On a worldwide basis, leptospirosis is the most widespread zoonotic disease. Leptospirosis is also emerging as a significant infectious disease in urban slums, particularly in tropical regions. The infection is caused by spirochetes of the genus Leptospir Health and Human Services, Department of / National Institutes of Health 9/07/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $420,446 Grant Trans-NIH Recovery Act Research Support: Cochlear implants are commonly used in young children to treat deafness. This electronic device receives incoming sounds and electrically stimulates the auditory nerve, thereby bypassing the malfunctioning inner ear. Achieving optimal results with a cochl Health and Human Services, Department of / National Institutes of Health 8/01/2010
UNIVERSITY OF LOUISVILLE $1,559,561 Grant Trans-NIH Recovery Act Research Support: This proposal is based on a novel mechanism linking advanced age to destructive periodontal inflammation, which is targeted for new therapeutic intervention against periodontitis. The application therefore addresses the second thematic area of RFA-OD-10-0 Health and Human Services, Department of / National Institutes of Health 9/27/2010
UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO $1,297,000 Grant Trans-NIH Recovery Act Research Support: The University of Texas Health Science Center at San Antonio (UTHSCSA) has established the Institute for Integration of Medicine and Science (IIMS) as the home for our Clinical and Translational Science Award [CTSA). Our mission is to achieve optimal inte Health and Human Services, Department of / National Institutes of Health 9/09/2010
SEATTLE CHILDREN'S HOSPITAL $499,812 Grant Trans-NIH Recovery Act Research Support: Developmental defects of the cerebellum in humans have received less attention than other brainmalformations such as neural tube defects and cortical malformations. Yet, cerebellar malformations arecommon, affecting approximately 1/5000 births. Dandy-Walk Health and Human Services, Department of / National Institutes of Health 7/28/2010
BAYLOR COLLEGE OF MEDICINE $153,500 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Baylor College of Medicine (Baylor) is applying for a Clinical Trials Unit (CTU) in response to NIH RFA-AI-05-002 Units for HIV/AIDS Clinical Trials Networks. Baylor (presently Pediatric AIDS Clinical Trials Group [PAC Health and Human Services, Department of / National Institutes of Health 9/13/2010
ALBERT EINSTEIN COLLEGE OF MEDICINE $451,503 Grant Trans-NIH Recovery Act Research Support: (provided by applicant): This application addresses broad Challenge Area (04) Clinical Research, and the specific Challenge Topic 04-HL-103 Assess the role of leukocyte interaction with platelets, erythrocytes, and endothelium in the pathogenesis of heart Health and Human Services, Department of / National Institutes of Health 9/07/2010
UNIVERSITY OF PITTSBURGH THE $8,000 Grant Trans-NIH Recovery Act Research Support: Award Title: TNFalpha Control of a Surfactant Enzyme in Lung Injury Description: The purpose of this award is to fund the salary of an undergraduate student to perform summer biomedical research. Overall Purpose: The study purpose was to test if an injuri Health and Human Services, Department of / National Institutes of Health 8/24/2010
UNIVERSITY OF CALIFORNIA, DAVIS $63,097 Grant Trans-NIH Recovery Act Research Support: Activities in this supplemental request relate making CASP databases and CASP experience more easily accessible to researchers, educators, and students. Protein structure plays an ever increasing role in biology, and structure modeling and prediction have Health and Human Services, Department of / National Institutes of Health 8/20/2010
EC AMERICA INC $398,008 Contract : Product License Health and Human Services, Department of / National Institutes of Health 8/27/2010
WASHINGTON STATE UNIVERSITY $32,199 Grant Trans-NIH Recovery Act Research Support: DNA damage is one of the most important factors in cancer development in humans, and yet it also contributes to the therapeutic efficacy of many anti-cancer drugs. Thus, a better understanding of the mechanistic basis underlying DNA double strand break (D Health and Human Services, Department of / National Institutes of Health 8/13/2010
UNIVERSITY OF WASHINGTON $112,652 Grant Trans-NIH Recovery Act Research Support: Insulin like molecules alter system-wide protein turnover, yet the effects on individual proteins is unclear. A change in a protein's turnover can alter the stoichiometry of the active protein and ultimately affect the efficiency of a pathway. Additiona Health and Human Services, Department of / National Institutes of Health 2/05/2009
GEORGETOWN UNIVERSITY (THE) $153,443 Grant Trans-NIH Recovery Act Research Support: The applicants appreciate the substantial disparities in cancer risk, screening, treatments and outcomes for ethnic and racial minorities. A major barrier to understanding the biological reasons, and the exogenous risk factors for cancer and cancer outco Health and Human Services, Department of / National Institutes of Health 9/03/2010
UNIVERSITY OF ALABAMA AT BIRMINGHAM $201,173 Grant Trans-NIH Recovery Act Research Support: The overall goal of the ongoing studies is to define the structure/function relationships of a family of paired Ig-like receptors of activating (PIR-A) and inhibitory (PIR-B) isoforms that we identified in mice. The hypothesis that PIR-A and PIR-B play r Health and Human Services, Department of / National Institutes of Health 8/09/2010
MCLEAN HOSPITAL CORPORATION, THE $1,896,390 Grant Trans-NIH Recovery Act Research Support: The limited supply of red blood cells (RBC) and platelets is a serious medical issue that can have life-threatening consequences for transfusion-dependent patients, particularly those who develop platelet allo-immunity. The low prevalence of O Rh-negative Health and Human Services, Department of / National Institutes of Health 9/20/2010
GLSYNTHESIS INC. $191,458 Grant Trans-NIH Recovery Act Research Support: Oligomeric, conjugated water soluble (p-phenylene-ethynes) (G?OPEsG?) are strongly fluorescent at long wavelengths and are 'superquenchable' by interaction with appropriate small molecules. They and the polymeric versions (G?PPEsG?), however, have signif Health and Human Services, Department of / National Institutes of Health 6/14/2010
SCRIPPS RESEARCH INSTITUTE, THE $291,750 Grant Trans-NIH Recovery Act Research Support: Recombination that occurs during meiosis is essential for genetic diversity, species fitness, and evolution. Here the shuffling of chromosomes does not occur at random but rather at distinct hotspots in eukaryotic genomes. The anatomy and control of recom Health and Human Services, Department of / National Institutes of Health 9/22/2010
VARIAN MEDICAL SYSTEMS, INC. $271,087 Contract : Recovery Varian Rapid Arc Upgrade for Varian Clinac 21EX, S/N 2999, NIH# 01633590 Health and Human Services, Department of / National Institutes of Health 8/03/2010
CHARLES RIVER LABORATORIES, INC. $60,657 Contract : 2010 - Approximately 13 shipments each of 17 Female Hartley Guinea Pigs 300 - 350 Grams totalling approximately $15,867.41 2011 - Approximately 24 shipments each of 17 Female Harltey Guinea Pigs 300 - 350 Grams totalling approximately $31,063.92 Health and Human Services, Department of / National Institutes of Health 9/29/2010
UNIVERSITY OF CONNECTICUT $955,216 Grant Trans-NIH Recovery Act Research Support: An existing public-academic research partnership between the Connecticut Department of Correction (CDOC), the University of Connecticut, and the University of Connecticut Health Center seek to continue research infrastructure development to achieve a tran Health and Human Services, Department of / National Institutes of Health 7/30/2010
JOHNS HOPKINS UNIVERSITY, THE $194,420 Grant Trans-NIH Recovery Act Research Support: LINE-1, or L1, elements, are the most prolific and prominent mobile elements in mammalian genomes. In the human and mouse genomes, active L1s and their relics account for 17-20% of the genome mass. By providing activities necessary for mobility of Alu and Health and Human Services, Department of / National Institutes of Health 9/24/2010
OHIO STATE UNIVERSITY, THE $5,101 Contract : Ohio State University has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of specimens (total of 44 cases). The collection of the specimens is being p Health and Human Services, Department of / National Institutes of Health 9/15/2010
NEW YORK UNIVERSITY $217,500 Grant Trans-NIH Recovery Act Research Support: In recent years, Drosophila, with its genetic amenability and the relatively small size of its brain, has been very successfully developed as a model system to study how neural circuits control behavior. We will investigate how the brain processes color v Health and Human Services, Department of / National Institutes of Health 9/30/2010
PRIMATE PRODUCTS, INCORPORATED $185,760 Contract : Providing four seperate species for NIAIDS use. Phillipine cynos, African Greens, Common Marmosets and squirrel monkeys. Health and Human Services, Department of / National Institutes of Health 9/20/2010
TUFTS MEDICAL CENTER PARENT, INC. $0 Grant Trans-NIH Recovery Act Research Support: While achieving optimal health outcomes for persons with chronic medical conditions requires that patients adhere to effective medications, few simple and effective methods to accomplish this have been developed. This proposed pilot study develops an inn Health and Human Services, Department of / National Institutes of Health 9/22/2010
UNIVERSITY OF WASHINGTON $727,595 Grant Trans-NIH Recovery Act Research Support: Mycoplasma genitalium has been implicated in both male and female reproductive tract infections and may account for up to 25% of all cases of nongonococcal urethritis (NGU). This emerging sexually transmitted organism has been independently associated wit Health and Human Services, Department of / National Institutes of Health 8/23/2010
MAYO CLINIC $394,250 Grant Trans-NIH Recovery Act Research Support: Background: Food intolerances are a common complaint, of which gluten sensitivity is one of the most common and serious. It has 2 distinct manifestations, Celiac Disease (CD) and Dermatitis Herpetiformis (DH), which affect 1% of the population, a number t Health and Human Services, Department of / National Institutes of Health 7/12/2010
TRUSTEES OF BOSTON UNIVERSITY $134,327 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The healthy eye possesses a unique physiological and evolutionary adaptation that modifies the expression of immunity. This physiological adaptation is part of ocular immune privilege. The physiological role of immune Health and Human Services, Department of / National Institutes of Health 7/20/2010
UNIVERSITY OF OKLAHOMA $205,152 Grant Trans-NIH Recovery Act Research Support: Pressure ulcers significantly affect quality of life and overall healthcare costs of wheelchair users with spinal cord injury (SCI). Current clinical practice includes using wheelchair power seat function (PSF) to attain specific seating angles, durations Health and Human Services, Department of / National Institutes of Health 9/02/2010
WASHINGTON UNIVERSITY, THE $152,000 Grant Trans-NIH Recovery Act Research Support: The Alvin J. Siteman Cancer Center (SCC) at Washington University School of Medicine and Barnes-Jewish Hospital received NCI designation as a Clinical Cancer Center in 2001, and as a Comprehensive Cancer Center in 2004. The SCC is composed of eight multid Health and Human Services, Department of / National Institutes of Health 9/16/2010
NORTH DAKOTA STATE UNIVERSITY $203,332 Grant Trans-NIH Recovery Act Research Support: Project Goals. We are using a powerful new paradigm, the quadrature-phase motion technique to measure the magnitude of both luminance-based first-order (Grating Induction) and contrast-based second-order (Contrast-Contrast) inhibitory visual processes ove Health and Human Services, Department of / National Institutes of Health 9/17/2010
RFCUNY - HUNTER COLLEGE $143,890 Grant Trans-NIH Recovery Act Research Support: The delivery of mRNA from the nucleus to distal dendritic sites is imperative for localized gene expression. This is required for protein synthesis-dependent changes in synapse plasticity in response to neuro- transmission. Several mRNA-binding proteins ( Health and Human Services, Department of / National Institutes of Health 7/20/2010
UNIVERSITY OF SOUTHERN CALIFORNIA $38,900 Grant Trans-NIH Recovery Act Research Support: Despite advances in antiviral therapy, control of infection with the human immunodeficiency virus (HIV) is not completely achieved in all patients. A majority of HIV-infected women receiving HAART present good virus control and recovery of CD4 counts upon Health and Human Services, Department of / National Institutes of Health 7/06/2010
UNIVERSITY OF KENTUCKY $222,750 Grant Trans-NIH Recovery Act Research Support: Protein kinases mediate many cell signaling events, and their tight control is essential for regulating vital processes ranging from cell division to energy metabolism. Thus, it is not surprising that protein kinases are directly or indirectly involved in Health and Human Services, Department of / National Institutes of Health 1/19/2010
JOHNS HOPKINS UNIVERSITY, THE $162,114 Grant Trans-NIH Recovery Act Research Support: 501HD038384-07, GENOMIC APPROACHES TO ANEUPLOIDY ? REQUEST FOR ADMINISTRATIVE SUPPLEMENT We seek an administrative supplement to directly extend experiments in Specific aims 1 and 2 to forward progress in this grant and in the community of Down syndrome r Health and Human Services, Department of / National Institutes of Health 7/07/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $106,295 Grant Trans-NIH Recovery Act Research Support: This goal of this short-term mentored senior career development award is to add to PI's research areas an understanding of the concepts, methods, and current research in epigenetics to his on-going work on biodevelopmental mechanisms that underlie observe Health and Human Services, Department of / National Institutes of Health 9/27/2010
OHIO STATE UNIVERSITY, THE $2,626,966 Grant Trans-NIH Recovery Act Research Support: Transmitted by sand fly vectors, Leishmania are obligate intracellular parasites that cause a wide range of diseases, including cutaneous (CL), mucocutaneous (MCL) and visceral leishmaniasis (VL). Over 12 million people currently suffer from leishmaniasis Health and Human Services, Department of / National Institutes of Health 9/29/2010
UNIVERSITY OF MARYLAND $130,827 Grant Trans-NIH Recovery Act Research Support: The cytokine IL-4 is produced by TH2 lymphocytes, NKT cells, and by cells of the innate immune system including mast cells, and eosinophils. It was originally identified as a stimulator of B cell proliferation, but it is now clear that IL-4 can regulate p Health and Human Services, Department of / National Institutes of Health 7/06/2010
UNIVERSITY OF CALIFORNIA, LOS ANGELES $670,197 Grant Trans-NIH Recovery Act Research Support: DEVELOPMENT OF A TULAREMIA VACCINE THAT IS SAFER AND MORE POTENT THAN LVS Francisella tularensis (Ft) causes tularemia, a serious and potentially fatal disease. Because Ft has an extraordinarily high infectivity, causes high morbidity and mortality, is Health and Human Services, Department of / National Institutes of Health 7/09/2010
UNIVERSITY OF NEBRASKA $993,063 Grant Trans-NIH Recovery Act Research Support: The overarching goal of the proposed project is to develop an innovative, durable academic-community research enterprise co-created and grounded by an equitable partnership among NebraskaG??s leading health science center and key community organizations w Health and Human Services, Department of / National Institutes of Health 8/19/2010
VIBETECH, INC. $199,998 Grant Trans-NIH Recovery Act Research Support: This project aims to develop and test a Passive Vibration Therapy (PVT) device for the lower extremities. Researchers will investigate the ability of the PVT device developed under this award to reduce fracture risk associated with falls in institutionali Health and Human Services, Department of / National Institutes of Health 7/15/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $168,161 Grant Trans-NIH Recovery Act Research Support: This K18 application is to provide advanced mentorship in complex dynamic system analyses of clinical and biomarker data for major depressive disorder (MDD) and bipolar disorder (BD). MDD is a serious, debilitating illness that is projected to become the Health and Human Services, Department of / National Institutes of Health 9/28/2010
CARNEGIE MELLON UNIVERSITY $55,192 Grant Trans-NIH Recovery Act Research Support: Our primary goals are to assess the influence of the social environment on susceptibility to upper respiratory illness and to identify the pathways through which environmental factors get under the skin to influence disease expression. We hypothesize that Health and Human Services, Department of / National Institutes of Health 8/16/2010
DANA-FARBER CANCER INSTITUTE, INC. $52,154 Grant Trans-NIH Recovery Act Research Support: All viruses infecting vertebrates interact with receptors during the process of cell infection, and also are challenged by antibodies that are either pre-existing in the host or generated shortly after infection. Both these interactions are critical to th Health and Human Services, Department of / National Institutes of Health 9/01/2010
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO $999,777 Grant Trans-NIH Recovery Act Research Support: Infrastructure for Community-Linked Research to Address Disparities in HIV/AIDS To respond to the domestic HIV epidemic in general and reduce health disparities in HIV prevalence specifically, this project will build sustainable infrastructure to enable h Health and Human Services, Department of / National Institutes of Health 7/06/2010
QIAGEN INC. $87,368 Contract : QIASymphony SP Health and Human Services, Department of / National Institutes of Health 7/16/2010
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE $12,000 Grant Trans-NIH Recovery Act Research Support: Participants at last year's CNS meeting in RTP discussed the meeting venue for 2010 and investigators reached consensus that a West Coast location would be preferable, as two of the CNS programs are located on the West Coast. The Catamaran Resort Hotel a Health and Human Services, Department of / National Institutes of Health 7/17/2010
KECK GRADUATE INSTITUTE OF APPLIED LIFE SCIENCES $153,336 Grant Trans-NIH Recovery Act Research Support: Software development to facilitate EXPAR assay design for pathogen detection: This project utilizes the isothermal Exponential Amplification Reaction (EXPAR) to enable rapid, simple, and inexpensive nucleic acid testing for identification of Herpes Simple Health and Human Services, Department of / National Institutes of Health 6/01/2010
TRUSTEES OF INDIANA UNIVERSITY $195,568 Grant Trans-NIH Recovery Act Research Support: Bacteria often exist in surface-attached multicellular communities called biofilms, a state in which they can evade the immune system and antibiotic therapy, thereby complicating the treatment of infectious diseases. Most bacteria utilize surface structur Health and Human Services, Department of / National Institutes of Health 8/25/2010
MARCH OF DIMES FOUNDATION $65,388 Contract : For the Supplement, a Graduate student will participate in all aspects of the parent grant that are related to the genetic analyses. In the first phase of the project, he would contribute to tasks related to sample handling and tracking, DNA extraction an Health and Human Services, Department of / National Institutes of Health 9/01/2010
MCLEAN HOSPITAL CORPORATION, THE $79,000 Grant Trans-NIH Recovery Act Research Support: We have developed a plan for a NINDS research organization/consortium to develop, characterize and study iPS cell lines for Parkinson's disease (PD). The consortium is organized with several top research teams with both clinical and basic science expertis Health and Human Services, Department of / National Institutes of Health 9/28/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $50,000 Grant Trans-NIH Recovery Act Research Support: Chronic HIV-1 infection is characterized by loss of CD4+ T cells, chronic immune activation and progressive immune dysfunction. Regulatory CD4+ T (Tregs) cells play a crucial role in controlling immune activation in several disease models, but the role of Health and Human Services, Department of / National Institutes of Health 8/09/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $50,000 Grant Trans-NIH Recovery Act Research Support: The focus of my career in patient-oriented research (POR) has been to study how interactions between HIV- 1 and key cells involved in innate and adaptive immunity influence control of HIV-1 replication and disease progression. The ultimate goal of these s Health and Human Services, Department of / National Institutes of Health 8/02/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $500,000 Grant Trans-NIH Recovery Act Research Support: This project supports the purchase of an instrument that is dedicated to isolate cells from a variety of animal cells that are being used to develop new therapies at the University of Pennsylvania. In addition, this proposal will create or retain two jobs Health and Human Services, Department of / National Institutes of Health 7/22/2010
SYSMEX AMERICA, INC. $164,465 Contract : Sysmex Cellavisoion DM96, 3 Cellavision Database Licenses, and DM96 B/F Option (Product Code is 6515, product description is Medical and Surgical Instrument, Equipment, and Supply). Health and Human Services, Department of / National Institutes of Health 7/16/2010
ACADEMIC EDGE INC $886,817 Grant Trans-NIH Recovery Act Research Support: There has been significant improvement in our understanding and articulation of ideal patient and provider diabetes management practices. However, these optimal diabetes care behaviors are often not achieved in real world clinical experiences as a result Health and Human Services, Department of / National Institutes of Health 9/03/2010
SRI INTERNATIONAL $3,100,000 Contract : IN VITRO SCREENING OF COMBINATIONS OF DRUGS TO TREAT CANCER We will test combinations of drugs and other potential cancer therapies as indicted in the work assignment. The goal of this project is to test the effects of 100 cancer therapeutic agents in all Health and Human Services, Department of / National Institutes of Health 9/20/2010
VIRGINIA COMMONWEALTH UNIVERSITY $245,886 Grant Trans-NIH Recovery Act Research Support: This application requests funds to accelerate the pace of data extraction and data analysis necessary to accomplish the specific aims of the original grant, which is active through August 31, 2011. No unreviewed new research directions are proposed. All o Health and Human Services, Department of / National Institutes of Health 7/29/2010
CHILDREN'S HOSPITAL MEDICAL CENTER $386,385 Grant Trans-NIH Recovery Act Research Support: The Pediatric Rheumatology Tissue Core (PRTR) within Cincinnati P30 Rheumatic Diseases Core Center is a long standing, proven, and valuable resource for pediatric rheumatic disease translational research studies and houses approximately 80,000 samples. S Health and Human Services, Department of / National Institutes of Health 9/10/2010
UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO ,THE $0 Grant Trans-NIH Recovery Act Research Support: This project addresses broad Challenge Area (15) Translational Science and specific Challenge Topic, 15-AI-103: Develop drugs for neglected tropical diseases, with a special emphasis on malaria. New drugs are desperately needed to treat visceral leishmani Health and Human Services, Department of / National Institutes of Health 9/29/2010
SONOSITE, INC. $9,000 Grant Recovery Act of 2009: Capital Improvement and Maintenance: Purchase of a ultrasound transducer. Health and Human Services, Department of / National Institutes of Health 7/19/2010
HARVARD COLLEGE, PRESIDENT & FELLOWS OF $500,000 Grant Trans-NIH Recovery Act Research Support: A major goal of the worldwide malaria eradication program is the reduction and eventual elimination of malaria transmission. In order to achieve this goal, the development of drugs to prevent transmission becomes a high priority and requires new approache Health and Human Services, Department of / National Institutes of Health 9/29/2010
NATIONAL BUREAU OF ECONOMIC RESEARCH, INC. $218,509 Grant Trans-NIH Recovery Act Research Support: Smokeless tobacco (ST) has been determined to be hazardous to health. However, there have been no studies which have examined the impact of ST advertising on ST use and there is very little prior research on the targeting of ST advertising. Research on th Health and Human Services, Department of / National Institutes of Health 8/26/2010
UNIVERSITY OF CALIFORNIA, DAVIS $892,251 Grant Trans-NIH Recovery Act Research Support: A. Award title: Development of a Multiplex Assay for Viral Pathogens Causing Hemorrhagic Fever B. Overall purpose of the Award: Develop rapid, highly sensitive and specific, flexible, simple, and cost-effective diagnostic techniques to detect and diffe Health and Human Services, Department of / National Institutes of Health 8/16/2010
UNIVERSITY OF TENNESSEE $284,180 Grant Trans-NIH Recovery Act Research Support: Peptide-Cell Interactions in Saccharomyces cerevisiae. This project is to elucidate the molecular details of the interaction of a peptide pheromone with its cognate receptor in the yeast S. cerevisiae. The system serves as a model for the interaction of p Health and Human Services, Department of / National Institutes of Health 8/31/2010
PACIFIC INSTITUTE FOR RESEARCH AND EVALUATION $243,663 Grant Trans-NIH Recovery Act Research Support: PROJECT SUMMARY: The social costs of HIV/AIDS are extremely high. Among the most vulnerable to harm are adolescent orphans, and especially girl orphans, in high HIV prevalence areas. They are at great risk of school dropout and many will soon commence b Health and Human Services, Department of / National Institutes of Health 7/19/2010
CHARLES RIVER LABORATORIES, INC. $216,067 Contract : The research focus is to provide support to animal studies within NIAID and will entail staffing support for 'cage to bench-side' for both rodent and guinea pig work with the H1N1 virus. The specific focus is on disease transmission. This scope of work Health and Human Services, Department of / National Institutes of Health 8/13/2010
DUKE UNIVERSITY $7,175,320 Grant Trans-NIH Recovery Act Research Support: Palliative care, a relatively new subspecialty, needs to build its evidence base supporting clinical practice. The Institute of Medicine has identified palliative care as a comparative effectiveness research priority, but increased scientific productivity Health and Human Services, Department of / National Institutes of Health 9/30/2010
UNIVERSITY OF FLORIDA $325,431 Grant Trans-NIH Recovery Act Research Support: Absorption; Acinar Cell; Aciner Cells; Assay; B cell differentiation factor; B cell stimulating factor 2; B-Cell Differentiation Factor-2; B-Cell Stimulatory Factor-2; BCDF; BSF-2; BSF2; BSF2 (B cell stimulating factor 2); Binding Proteins; Bioassay; Biol Health and Human Services, Department of / National Institutes of Health 7/12/2010
TRUSTEES OF BOSTON UNIVERSITY $512,479 Grant Trans-NIH Recovery Act Research Support: Anti-retroviral therapy (ART) for human immunodeficiency virus (HIV)-1 infection has prolonged and improved quality and longevity of life. Nonetheless, disease morbidities associated with HIV abound, including cognitive dysfunction seen during the later s Health and Human Services, Department of / National Institutes of Health 9/03/2010
ALBERT EINSTEIN COLLEGE OF MEDICINE $39,830 Grant Trans-NIH Recovery Act Research Support: The proposed Specialized Cooperative Center Program in Reproductive and Infertility Research (SCCPIR) is focused upon female reproductive biology with Dr. Jeffrey W. Pollard as Principal Investigator. It has evolved out of an institutional supported Cente Health and Human Services, Department of / National Institutes of Health 9/15/2010
CASE WESTERN RESERVE UNIVERSITY $24,952 Grant Trans-NIH Recovery Act Research Support: The supplement has accelerated the tempo of scientific research. This grant also support to explore our experiments to investigate involvement of innate immunity observed in age-related retinal diseases. The funds from this supplement have been used compl Health and Human Services, Department of / National Institutes of Health 7/01/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $50,000 Grant Trans-NIH Recovery Act Research Support: The proposal is an administrative supplement to the K01 grant Mathematical Techniques for Control of Epidemic Trypanosoma cruzi Transmission. It requests funding for a geographic investigator to accelerate the progress of the parent award. Health and Human Services, Department of / National Institutes of Health 8/02/2010
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. $444,939 Grant Trans-NIH Recovery Act Research Support: The interplay of biology and behavior, and interactions between specific serovars, reservoir hosts, humans and the physical environment contributes to the transmission of Salmonella from non-food sources. The overall objective of this application is to es Health and Human Services, Department of / National Institutes of Health 9/07/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $200,002 Grant Trans-NIH Recovery Act Research Support: Significant morbidity and mortality of diabetes results from its complications of renal impairment, accelerated cardiovascular disease, and loss of vision. Abnormal vascular remodeling are integral components of diabetic macro-vascular and micro-vascular Health and Human Services, Department of / National Institutes of Health 9/30/2010
REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE $42,558 Grant Trans-NIH Recovery Act Research Support: The focus of our research is to determine how signal transduction regulates directed motility and behavior in the bacterium Myxococcus xanthus using an integrated approach that combines biochemistry, genetics, and cell biology. M. xanthus is an excellent Health and Human Services, Department of / National Institutes of Health 8/06/2010
NEW YORK UNIVERSITY (INC) $1,192,128 Grant Trans-NIH Recovery Act Research Support: Due to a successful biomedical research effort great strides have been made in understanding pathologic processes and developing new therapies for once untreatable diseases. Nonetheless, there are speed bumps on the road to more efficient and productive r Health and Human Services, Department of / National Institutes of Health 7/29/2010
WASHINGTON METROPOLITAN AREA TRANSIT AUTHORITY $59,668 Contract : These ARRA funds provided SmartBenefits on SmarTrip cards to NIH employees that they may use to ride MetroBus or MetroRail. The fare media may also be used on DASH, Ride On, Fairfax Connector, ART, CUE, Loudoun County Transit, Omniride, TheBus, DC Circula Health and Human Services, Department of / National Institutes of Health 3/15/2010
UNIVERSITY OF CALIFORNIA, LOS ANGELES $414,421 Grant Trans-NIH Recovery Act Research Support: Infectious diseases comprise the leading cause of morbidity and mortality in low to middle income countries. Malaria, tuberculosis, HIV disease and gastrointestinal illnesses pose 2/3 of the world population at risk. Investigators at UCLA from the School Health and Human Services, Department of / National Institutes of Health 9/26/2010
UNIVERSITY OF HAWAII SYSTEMS $1,400,000 Grant Trans-NIH Recovery Act Research Support: The Comparative Effectiveness Research (CER) Approaches to Eliminate Cardiometabolic Disparities (ECD)' is a revision application that includes 4 CER activities to integrate comparative effectiveness research methods with existing health disparities appro Health and Human Services, Department of / National Institutes of Health 7/31/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $66,000 Grant Trans-NIH Recovery Act Research Support: TO DETERMINE THE STRUCTURE OF THE +?2AR-Gs COMPLEX BY X-RAY CRYSTALLOGRAPHY. The complex of a G protein coupled receptor (GPCR) and its G protein is the fundamental signaling unit for the majority of hormones and neurotransmitters. There has been remarkab Health and Human Services, Department of / National Institutes of Health 7/30/2010
FLORIDA STATE UNIVERSITY, THE $573,586 Grant Trans-NIH Recovery Act Research Support: Like humans, juvenile songbirds learn to imitate the vocal patterns of an adult during a sensitive period of development. Also like humans, songbird vocal patterns are controlled by a forebrain network that includes pre-motor, striatal, and auditory path Health and Human Services, Department of / National Institutes of Health 5/12/2009
INFECTIOUS DISEASE RESEARCH INSTITUTE $432,300 Grant Trans-NIH Recovery Act Research Support: Mycobacterium tuberculosis is a major human pathogen causing significant human suffering worldwide. As the leading cause of death from a single bacterial infection, it is imperative to understand the biology, physiology and pathogenicity of the organism. Health and Human Services, Department of / National Institutes of Health 6/18/2009
UNIVERSITY OF MARYLAND $213,940 Grant Trans-NIH Recovery Act Research Support: Biosensor platforms capable of discriminating molecules on the basis of their molecule masses at the level of individual molecules offer significant promise towards advancing our fundamental understanding of biological processes. This project addresses th Health and Human Services, Department of / National Institutes of Health 8/12/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $99,000 Grant Trans-NIH Recovery Act Research Support: A major impediment to progress during the second stage of labor comes from the resistance of the pelvic floor tissues to stretch. This resistance depends mostly upon the elastic and viscous properties of the pubovisceral muscle and perineal body. The know Health and Human Services, Department of / National Institutes of Health 9/02/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $99,165 Grant Trans-NIH Recovery Act Research Support: The NIH Roadmap recognizes a 'pressing need to better quantify clinically important symptoms and outcomes, including pain, fatigue, and quality of life.' The NIH Roadmap has lead to an unprecedented number of large-scale initiatives for health-related qua Health and Human Services, Department of / National Institutes of Health 9/21/2010
EMORY UNIVERSITY $741,299 Grant Trans-NIH Recovery Act Research Support: The gastrointestinal epithelium functions as a dynamic barrier that serves as an interface between luminal contents and underlying tissue compartments, and is thus vital in maintaining mucosal homeostasis. Mucosal wounds have been observed following enter Health and Human Services, Department of / National Institutes of Health 7/12/2010
ALBERT EINSTEIN COLLEGE OF MEDICINE $173,370 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Summary Formation of such an elaborate structure as the nervous system requires the concerted action of numerous molecules many of which reside in the molecularly complex extracellular matrices (ECMs). Neurons receive Health and Human Services, Department of / National Institutes of Health 7/07/2010
RESEARCH TRIANGLE INSTITUTE $2,899,367 Contract : RTI will develop an authoritative Nanomaterial Registry to provide consistent and curated information on the biological and environmental interactions of well-characterized nanomaterials. Health and Human Services, Department of / National Institutes of Health 7/02/2010
UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON $1,844,556 Grant Trans-NIH Recovery Act Research Support: Preeclampsia (PE) is a dangerous complication of pregnancy characterized by sudden onset hypertension, proteinuria, inflammation, and coagulopathy. The condition affects approximately 7% of first pregnancies and accounts for over 80,000 premature births e Health and Human Services, Department of / National Institutes of Health 9/24/2010
COMPOUND FOCUS INC $4,999,355 Contract : Compound Focus will provide chemical repository services that will 1) provide interactive central chemical registry and distribution services, 2) procure, receive, analyze, manage, store and distribute individual chemical compounds and 3) produce, distrib Health and Human Services, Department of / National Institutes of Health 9/24/2010
YALE UNIVERSITY $46,553 Grant Trans-NIH Recovery Act Research Support: Intramembrane proteolysis is an important and widespread biochemical mechanism in cell biology: many membrane proteins undergo intramembrane proteolysis to become activated for signal transduction, or to be converted to poorly soluble amyloidal peptides t Health and Human Services, Department of / National Institutes of Health 9/30/2010
NORTHSHORE UNIVERSITY HEALTHSYSTEM RESEARCH INSTITUTE $188,932 Grant Trans-NIH Recovery Act Research Support: This supplemental award is focused on increasing activities and personnel to boost participant enrollment (fathers) and retention (mothers and fathers). Improvement in these numbers is the main deliverable. Health and Human Services, Department of / National Institutes of Health 9/22/2010
UNIVERSITY OF WASHINGTON $2,042,620 Grant Trans-NIH Recovery Act Research Support: The nematode C. elegans is one of the most thoroughly studied organisms in biology. It is used by thousands of scientists to gain insight into basic biological processes, many of which are shared with humans. Its genome is fully sequenced and is now the Health and Human Services, Department of / National Institutes of Health 8/19/2010
THE JACKSON LABORATORY $745,063 Grant Trans-NIH Recovery Act Research Support: The GO Consortium's Reference Genome project has revealed to us both the need and the unique opportunity to create an environment that supports team curation among the contributing functional annotation groups. This next-generation common curation environ Health and Human Services, Department of / National Institutes of Health 9/23/2010
UNIVERSITY OF IOWA, THE $1,000,000 Grant Trans-NIH Recovery Act Research Support: The University of Iowa Holden Comprehensive Cancer Center (HCCC), in collaboration with the Iowa Cancer Consortium (ICC), the Iowa Center for Education and Research on Therapeutics (CERT) and the Iowa Research Network (IRENE), propose development of a com Health and Human Services, Department of / National Institutes of Health 8/30/2010
BROWN UNIVERSITY IN PROVIDENCE IN STATE OF RI AND PROVIDENCE PLANTATIONS $254,810 Grant Trans-NIH Recovery Act Research Support: Natural killer T cells are a unique subset of T lymphocytes that rapidly produce Th1 and Th2 cytokines, most notably IFN-y and IL-4. NK T cells are CD4+CD8 or double negative and are dependent on a non-classical, non-polymorphic MHC class l-like molecule, Health and Human Services, Department of / National Institutes of Health 8/11/2010
UNIVERSITY OF WASHINGTON $163,790 Grant Trans-NIH Recovery Act Research Support: Multiple primate species, including 5 species of macaques (Macaca mulatta, M. nemestrina, M. fascicularis, M. assamensis, M. arctoides) and 3 species langurs (Semnopithecus entellus, Trachypithecus phayrei, Trachypithecus pileatus) coexist with humans in Health and Human Services, Department of / National Institutes of Health 9/07/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $344,400 Grant Trans-NIH Recovery Act Research Support: This supplement's aim is to increase our understanding of the mechanism by which airway inflammation may contribute to airway remodeling in asthma. Studies will focus on the role of the airway epithelium and T cells in contributing to airway remodeling u Health and Human Services, Department of / National Institutes of Health 7/26/2010
UNIVERSITY OF TEXAS AT AUSTIN $145,786 Grant Trans-NIH Recovery Act Research Support: The yeast plasmid 2 micron circle provides a simple model for a 'benign parasite genome'. The genetic organization of the plasmid has been evolutionarily optimized for its high-copy propagation without compromising the fitness of the host cells. The centr Health and Human Services, Department of / National Institutes of Health 8/27/2010
ALBERT EINSTEIN COLLEGE OF MEDICINE $166,000 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Despite evidence for a substantial genetic component, the inherited biological factors that promote extended life span (longevity) in humans remain unknown. The long-term goal of this Program is to identify genes that Health and Human Services, Department of / National Institutes of Health 9/14/2010
UNIVERSITY OF WISCONSIN SYSTEM $999,107 Grant Trans-NIH Recovery Act Research Support: The University of Wisconsin-Madison School of Nursing (PI), Lussier Community Education Center (CRA) and Goodman Community Center (CRA) will collaborate to establish Project WINNERS, an innovative statewide community-based research support network. Projec Health and Human Services, Department of / National Institutes of Health 7/23/2010
UNIVERSITY OF FLORIDA $45,762 Grant Trans-NIH Recovery Act Research Support: The high rate of unintended pregnancy can be attributed to inadequate access to or use of contraceptives, or both. It is important to provide alternative choices for effective contraception to meet the needs of people with different ethnic, cultural, and Health and Human Services, Department of / National Institutes of Health 7/01/2010
BRUKER BIOSPIN CORPORATION $3,650,000 Contract : 850NMR Spectrometer, Avance III 700 NMR spectrometer, Avance III 600 NMR console frequency conversion Health and Human Services, Department of / National Institutes of Health 6/22/2010
GILBANE BUILDING COMPANY $4,426,036 Contract : Design/Build job to furnish and install replacement air handling units for the Building 10 ACRF laboratory areas. Health and Human Services, Department of / National Institutes of Health 9/08/2010
GEORGETOWN UNIVERSITY (THE) $147,461 Contract : To acquire non-severable professional information Technology services. Health and Human Services, Department of / National Institutes of Health 8/04/2010
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO $154,500 Grant Trans-NIH Recovery Act Research Support: This project uses mice engineered with specific genetic changes in order to recreate Lowe Syndrome and study the renal pathology as it pertains to Lowe and other diseases. Health and Human Services, Department of / National Institutes of Health 9/30/2010
UNIVERSITY OF CALIFORNIA, LOS ANGELES $78,364 Grant Trans-NIH Recovery Act Research Support: Award Title: MOLECULAR ANALYSIS OF THE HOST IMMUNE RESPONSE IN LEPROSY This is a basic biomedical rsearch diversity supplement to the Molecular Analysis of Host Immune Responses in Leprosy project. The goal is to exam the role of the vitamin D pathway Health and Human Services, Department of / National Institutes of Health 9/07/2010
UNIVERSITY OF FLORIDA $52,916 Grant Trans-NIH Recovery Act Research Support: Peptide YY3-36 (PYY3-36) is an important hormone that is released post-prandially into the bloodstream from gut epithelial cells. Its secretion is related to caloric intake, and it induces satiety by acting on Y2 receptors in the brain. Recent research co Health and Human Services, Department of / National Institutes of Health 9/23/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $3,811,268 Grant Trans-NIH Recovery Act Research Support: Obesity is a worldwide health epidemic and a major contributor to the increased prevalence and severity of more than 60 metabolic, inflammatory, degenerative, cognitive, and neoplastic disorders. Broadly effective preventive and therapeutic strategies hav Health and Human Services, Department of / National Institutes of Health 9/30/2010
THERMO FISHER SCIENTIFIC (ASHEVILLE) LLC $8,226 Contract : Laboratory Equipment Order Health and Human Services, Department of / National Institutes of Health 9/21/2010
WAYNE STATE UNIVERSITY (INC) $490,704 Grant Trans-NIH Recovery Act Research Support: The long-term objective of our research is to augment the efficacy of the cancer treatment photodynamic thearpy (PDT). Three specific aims will test the hypothesis: 1) to demonstrate that cell killing after PDT requires a definitive, enzyme-controlled, S Health and Human Services, Department of / National Institutes of Health 7/16/2009
SRI INTERNATIONAL $461,755 Grant Trans-NIH Recovery Act Research Support: The goal of this project is to determine the role of LRRK2 mutation in the intrinsic vulnerability of nigrostriatal dopaminergic neurons and the susceptibility of this pathway to injury induced by environmental toxicants. The former subawardee (the Parkin Health and Human Services, Department of / National Institutes of Health 8/31/2010
SYNTHOSYS LLC $91,131 Contract : Synthosys shall provide consulting services in support of the STAR METRICS program, intended to help the federal government document the value of its investments in research and development in order to yield a more rigorous, transparent review of how our Health and Human Services, Department of / National Institutes of Health 8/10/2010
REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE $425,303 Grant Trans-NIH Recovery Act Research Support: The Framework to Address Drug Resistant Infections and Global Health will establish a major new program of health research and training at the University of California, focused on the detection, dynamics and control of drug resistant infections in the U.S Health and Human Services, Department of / National Institutes of Health 9/28/2010
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO $215,875 Grant Trans-NIH Recovery Act Research Support: Grant name: Novel small-molecule therapies for CF. The purpose of this project is to identify small-molecule inhibitors of P.aeruginosa biofilm formation for CF therapy. This second year of this pilot will focus on: (i) further screening and optimizatio Health and Human Services, Department of / National Institutes of Health 8/06/2010
UNIVERSITY OF NEW MEXICO $1,009,212 Grant Trans-NIH Recovery Act Research Support: his award supplements our main Center of Excellence Grant by supporting the development of a CER project in our borderlands population study area located in Hidalgo and Grant Counties, NM. This study uniquely develops innovative efforts to use CER for a Health and Human Services, Department of / National Institutes of Health 7/31/2010
UNIVERSITY OF UTAH, THE $2,491,798 Contract : The Systolic Blood pressure Intervention Trial, (SPRINT) contractor will conduct a multicenter, randomized clinical trial to determine whether treating systolic blood pressure to a lower goal than currently recommended, will reduce cardiovascular disease. Health and Human Services, Department of / National Institutes of Health 9/24/2010
UNIVERSITY OF CONNECTICUT $262,192 Grant Trans-NIH Recovery Act Research Support: Aging is associated with a dramatic increase in serious complications of influenza. Recent studies have linked influenza to excess mortality from cardiovascular diseases and pneumonia and influenza. Interactions between the immune system and influenza tha Health and Human Services, Department of / National Institutes of Health 8/02/2010
WASHINGTON UNIVERSITY, THE $2,725,275 Contract : We have been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically to establish a Tissue Source Site (TSS) Network capable of delivering clinically annotated biospecimens through either or both retr Health and Human Services, Department of / National Institutes of Health 9/27/2010
UNIVERSITY OF CONNECTICUT $144,397 Grant Trans-NIH Recovery Act Research Support: The long-range goal of this project is to determine the mechanism used by bacteria to select the proper cell division site at midcell. The three Min proteins, MinC, MinD and MinE, are required for proper site selection. The proteins have a unique cellular Health and Human Services, Department of / National Institutes of Health 9/16/2010
PALLADIAN PARTNERS, INC. $353,329 Contract : The NIH Office of the Director awarded the Office of Science Policy Analysis (OSPA), funds to be used to develop reports on the scientific outcomes resulting from research grants funded with ARRA dollars. In this second phase of the effort, the contractor Health and Human Services, Department of / National Institutes of Health 9/27/2010
PAIGE INDUSTRIAL SERVICES, INC. $7,974,093 Contract : Building 12 CIT Electrical Relisbility Phase 3 Health and Human Services, Department of / National Institutes of Health 9/24/2010
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO $191,802 Grant Trans-NIH Recovery Act Research Support: The therapeutic potential of small fragment homologous replacement (SFHR), developed in the PIs laboratory, was evaluated. Three Specific Aims will be pursued: Aim 1 - Optimize SFHR frequency by testing different sizes and types (single versus double stra Health and Human Services, Department of / National Institutes of Health 9/23/2010
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $339,807 Grant Trans-NIH Recovery Act Research Support: The aim of the project is to provide data on the feasibility of a genome-wide association study of oral cancer. Specific outcomes have been specified, to be addressed in a 12-month period. Currently, outcome No. 1 is under development. Outcome 1 involves Health and Human Services, Department of / National Institutes of Health 7/21/2010
UNIVERSITY OF WASHINGTON $48,891 Grant Trans-NIH Recovery Act Research Support: Each year, 9 million people are newly infected with Mycobacterium tuberculusis (mtb) and approximately 2 million die from Mtb worldwide. Mtb is particularly devastating in children, where dissemination and meningitis occur much more readily than in adult Health and Human Services, Department of / National Institutes of Health 8/02/2010
REGENTS OF THE UNIVERSITY OF MICHIGAN $51,579 Grant Trans-NIH Recovery Act Research Support: The long term objective of this application is to understand how HIV evades the immune response and establishes a chronic infection. Insights into how this occurs may lead to new strategies to augment the ability of the immune response to eradicate the vi Health and Human Services, Department of / National Institutes of Health 8/30/2010
CHILDRENS HOSPITAL OF PHILADELPHIA $4,215,211 Grant Trans-NIH Recovery Act Research Support: Mesenchymal stromal cells (MSCs), designated mesenchymal stem cells by some investigators, hold promise for the future therapy of diseases in nearly all tissues in the body. This application addresses Thematic Area 2, 'Translating Basic Science Discoverie Health and Human Services, Department of / National Institutes of Health 9/23/2010
NORTHWESTERN UNIVERSITY $68,729 Grant Trans-NIH Recovery Act Research Support: The Northwestern University Clinical Trials Unit (NU-CTU) is an existing and very productive clinical unit within the AIDS Clinical Trails Group. The NU-CTU has been invited to participate in the current ACTG application for a Network which will focus on Health and Human Services, Department of / National Institutes of Health 9/13/2010
CASE WESTERN RESERVE UNIVERSITY $54,200 Grant Trans-NIH Recovery Act Research Support: This pilot project aims to reduce the barriers to joint review of protocols by the University Hospitals Case Medical Center Institutional Review Board (UHCMC IRB) and the Papua New Guinea Institute of Medical Research Institutional Review Board (PNG IMR I Health and Human Services, Department of / National Institutes of Health 9/25/2010
UNIVERSITY OF ALABAMA AT BIRMINGHAM $500,859 Grant Trans-NIH Recovery Act Research Support: The probability of becoming infected upon exposure to HIV varies greatly from one individual to another, so does the rate of disease progression after infection. Determinants of such variable phenotypes include HLA class I (HLA-I) genes that mediate cytot Health and Human Services, Department of / National Institutes of Health 9/07/2010
KAISER FOUNDATION HOSPITALS $135,545 Grant Trans-NIH Recovery Act Research Support: This competing continuation application responds to PA 06-258, 'Alcohol Use Disorders: Treatment, Services Research and Recovery,' and extends a longitudinal study of 1,204 managed care Chemical Dependency (CD) patients. The proposed study follows a life Health and Human Services, Department of / National Institutes of Health 9/03/2010
UNIVERSITY OF OKLAHOMA $178,123 Grant Trans-NIH Recovery Act Research Support: Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common genetic diseases affecting 1 in 1000 Americans with the development of epithelial cysts in the kidney, liver, and pancreas. Naturally occurring mutations in two separate genes, Health and Human Services, Department of / National Institutes of Health 8/30/2010
EMORY UNIVERSITY $39,057 Grant Trans-NIH Recovery Act Research Support: Award Title: Gonococci: Genetics of Resistance to PMN Proteins (25S1): The development of antimicrobial resistance in the Gram-negative strict human pathogen Neisseria gonorrhoeae is a growing public health problem. The current CDC guideline states that c Health and Human Services, Department of / National Institutes of Health 9/20/2010
MASSACHUSETTS GENERAL HOSPITAL, THE $1,319,000 Grant Trans-NIH Recovery Act Research Support: This application requests funding to support the purchase of a state-of-the-art PET-SPECT-CT imaging system. This triple modality imager will actively support NIH-funded research addressing questions of fundamental importance in fields of experimental pha Health and Human Services, Department of / National Institutes of Health 7/08/2010
UNIVERSITY OF MIAMI $2,869,929 Grant ARRA Accelerating Adoption of Comparative Effectiveness Research (CER): Best practices for prevention and management of diabetes are known but not fully implemented in clinical and community settings. Working with the University of Miami, the Health Foundation of South Florida, a community partner in... Show more Health and Human Services, Department of / National Institutes of Health 9/13/2010
FLORIDA STATE UNIVERSITY, THE $264,045 Grant Trans-NIH Recovery Act Research Support: The purpose of this supplemental award is to enhance significantly the ability of the project to address its overall aim of identifying effective instructional practices for preschool children who are Spanish-speaking English language learners (ELLs). Spe Health and Human Services, Department of / National Institutes of Health 9/01/2010
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH $1,951,470 Grant Trans-NIH Recovery Act Research Support: Patient T cells may be genetically modified to target tumor through the introduction of genes encoding chimeric antigen recepters (CARS) specific to tumor associated antigens. Subsequently, CAR modified T cells may be adoptively transferred back into tumo Health and Human Services, Department of / National Institutes of Health 9/23/2010
UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON $370,500 Grant Trans-NIH Recovery Act Research Support: Lyme disease is the most prevalent tick-borne infection in North America and Eurasia and can cause long-term infections that affect the skin, joints, heart, and central nervous system. Thebacterium that causes Lyme disease (Borrelia burgdorferi) remains h Health and Human Services, Department of / National Institutes of Health 9/13/2010
NORTHWESTERN UNIVERSITY $1,492,049 Grant Trans-NIH Recovery Act Research Support: There are two significant barriers to including these PROs in comparative effectiveness research (CER): Lack of standardization of PRO scores required to make interpretable comparisons, and feasibility (including acceptability and cost to providers). We p Health and Human Services, Department of / National Institutes of Health 9/21/2010
UNIVERSITY OF MASSACHUSETTS $246,750 Grant Trans-NIH Recovery Act Research Support: Project Description: The importance of innate immune cells in the pathophysiology of alcoholic liver injury is evident from animal models and human studies. Resident macrophages in the liver are activated by endotoxin in portal circulation to produce infl Health and Human Services, Department of / National Institutes of Health 9/07/2010
JOHNS HOPKINS UNIVERSITY, THE $720,369 Grant Trans-NIH Recovery Act Research Support: Obesity is a major public health concern: the prevalence of obesity in the US has increased dramatically, reaching rates greater than 30%. Although lifestyle and pharmacological therapies are successful in the short term, subsequent regain of lost weight Health and Human Services, Department of / National Institutes of Health 7/28/2010
WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY $180,651 Grant Trans-NIH Recovery Act Research Support: An estimated 1 million Americans (and more than 90,000 New York City residents) have HIV infection. Despite recent advances, HIV/AIDS remains an important area for clinical investigation. This application describes the Cornell Clinical Trials Unit (CCTU), Health and Human Services, Department of / National Institutes of Health 9/27/2010
WASHINGTON UNIVERSITY, THE $42,294 Grant Trans-NIH Recovery Act Research Support: This application describes a 5-year training program for the development of an academic career in Pediatric Infectious Diseases, with a goal of independently directing research into parasite biology, pathogenesis, and therapy. Research design and methods: Health and Human Services, Department of / National Institutes of Health 8/30/2010
CASE WESTERN RESERVE UNIVERSITY $257,300 Grant Trans-NIH Recovery Act Research Support: The aims of this project are to accelerate the development of post-doctoral trainees in global health research, taking advantage of existing research programs and the Framework program at Case Western Reserve University (CWRU) and expanding existing relat Health and Human Services, Department of / National Institutes of Health 9/26/2010
DHARMACON, INC. $18,000 Contract : Cat. #AB-1453B-Verso 1st strand cDNA synthesis kit Health and Human Services, Department of / National Institutes of Health 9/24/2010
LELAND STANFORD JUNIOR UNIVERSITY, THE $999,388 Grant Trans-NIH Recovery Act Research Support: This application addresses the broad Challenge Area of Stem Cells (14) and specific Challenge Topic 14-HD- 102: Identifying Reprogramming Factors for Oocytes. In this proposal we build upon our current data, informatics and experimental expertise in the o Health and Human Services, Department of / National Institutes of Health 7/19/2010
WHITE POINT SYSTEMS INC $979,954 Contract : The Contractor will maintain the Global Data Center (GDC) to provide informatics support and to maintain a global dataset for the International Cooperative Biodiversity Groups (ICBG) Program. A unified relational database linking all steps of the data pip Health and Human Services, Department of / National Institutes of Health 9/30/2010
RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA $71,095 Grant Trans-NIH Recovery Act Research Support: This request for a Recovery Act Administrative Supplement as per NIH Notice (NOT -00-09-056) will accelerate progress on, 1 ROl HD0535S0?01A1, Combinations of genetic and environmental risk for externalizing in adolescence. We are requesting funds to empl Health and Human Services, Department of / National Institutes of Health 8/18/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $67,060 Grant Trans-NIH Recovery Act Research Support: Natural Killer T (iNKT) cells represent a lymphocyte population that has evolved to recognize glycolipid antigens presented by CD1d. Upon recognition of glycolipids, iNKT cells respond within hours, reminiscent of innate rather than adaptive functions. Th Health and Human Services, Department of / National Institutes of Health 9/20/2010
MICHIGAN STATE UNIVERSITY $252,664 Grant Trans-NIH Recovery Act Research Support: Stomata, microscopic pores in the epidermis of plants, function in innate immunity to restrict the entry of human and plant pathogenic bacteria into Arabidopsis leaves. To overcome stomate-based defense, the virulent Arabidopsis pathogen Pseudomonas syrin Health and Human Services, Department of / National Institutes of Health 8/09/2010
MICHIGAN STATE UNIVERSITY $353,446 Grant Trans-NIH Recovery Act Research Support: * The enteric nervous system (ENS), the part of the autonomic nervous system that resides within the gut wall, controls gastrointestinal (GI) motility, secretion, and local blood flow. The ENS can perform these complex functions because it contains a Health and Human Services, Department of / National Institutes of Health 7/26/2010
GILBANE BUILDING COMPANY $22,047,839 Contract : The electrical vaults and risers project requires the installation of multiple feeder circuits from the vault in MLP-9 to Building 10 J Wing. These circuits will be conduit and cable in busways. The pathways for underground tunnels for the busways in this Health and Human Services, Department of / National Institutes of Health 7/16/2010
SCRIPPS RESEARCH INSTITUTE, THE $272,300 Grant Trans-NIH Recovery Act Research Support: Sulfur metabilic pathways are essential for the virulence and survival of human pathogens. In microbial cysteine biosynthesis, sulfonucleotide reductases (Srs) catalyzethe reduction of adenosine 5'-phosphosulfate (APS) of 3'-phosphoadenosine 5'phosphosul Health and Human Services, Department of / National Institutes of Health 7/12/2010
3-C INSTITUTE FOR SOCIAL DEVELOPMENT, INC. $199,995 Grant Trans-NIH Recovery Act Research Support: Supports initial prototype development and feasibility testing for the Research Implementation and Management System (RIMS) ? an integrated suite of tools for the many tasks required to conduct research with human participants, including recruitment, scre Health and Human Services, Department of / National Institutes of Health 7/08/2010
COLORADO SEMINARY $347,910 Grant Trans-NIH Recovery Act Research Support: Biochemical probes are molecules that can be used to study how metabolism operates at the cellular and molecular level. These studies are essential for understanding the underlying mechanisms of life at the molecular level, and they have specific applica Health and Human Services, Department of / National Institutes of Health 6/25/2010
UNIVERSITY OF PITTSBURGH THE $3,001,400 Contract : To establish a Tissue Source Site (TSS) Network capable of delivering clinically annotated biospecimens through either or both retrospective and prospective collections. The tissues and clinical data will be delivered to one of the TCGA's Biospecimen Core Health and Human Services, Department of / National Institutes of Health 9/28/2010
UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON $344,250 Grant Trans-NIH Recovery Act Research Support: The overall goal of this project is to develop more effective therapeutic regimens for the treatment of colorectal cancer. These regimens will target not only malignant epithelial cells of the tumor, but also the cancer stem cells responsible for tumor r Health and Human Services, Department of / National Institutes of Health 8/30/2010
NORTH DAKOTA STATE UNIVERSITY $197,514 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): In the developed world, the U.S. has the highest rate of adolescent pregnancy, which is associated with increased risk of fetal growth restriction and premature delivery. Both preterm delivery and low birth weight are Health and Human Services, Department of / National Institutes of Health 7/29/2010
UNIVERSITY OF NORTH DAKOTA $27,600 Grant Trans-NIH Recovery Act Research Support: Project Summary/Abstract Alzheimer's disease (AD) is a complex neurodegenerative disorder for which there is presently no effective therapy. While some genetic mutations are responsible for the familial AD forms, the causative factors for the non-familia Health and Human Services, Department of / National Institutes of Health 6/04/2010
ALBERT EINSTEIN COLLEGE OF MEDICINE $3,994,132 Grant Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This project applies genomic and high-throughput genetic strategies to the global health emergency of tuberculosis. It creates new resources that will bridge clinic and laboratory, and quicken research for new, cheaper Health and Human Services, Department of / National Institutes of Health 9/29/2010
ONEIDA COMMUNICATIONS, INC. $4,158,022 Contract : Professional services to provide Infrastructure Installation and procurement for Bld 10 F wing Health and Human Services, Department of / National Institutes of Health 9/20/2010
NEW YORK UNIVERSITY (INC) $495,241 Grant Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (08): Genomics, and specific Challenge Topic 08-DK-107: Nuclear Receptor Mediated Assembly of Functional Transcriptional Units.The nuclear receptor ROR?t plays a critical role in the development and function Health and Human Services, Department of / National Institutes of Health 7/26/2010
UNIVERSITY OF CALIFORNIA, SAN DIEGO $324,820 Grant Trans-NIH Recovery Act Research Support: Medical decision support tools are increasingly available on the Internet and are being used by lay persons as well as health care professionals. The goal of some of these tools is to provide an individualized prediction of future health care related even Health and Human Services, Department of / National Institutes of Health 9/10/2010
UNIVERSITY OF TEXAS AT EL PASO $376,789 Grant Trans-NIH Recovery Act Research Support: Trypanosoma cruzi causes Chagas' disease, which affects over 11 million people in Latin America. Of those infected, about 5 million will develop severe cardiac and/or digestive disorders. Annually, up to 50,000 people may die and many others will become Health and Human Services, Department of / National Institutes of Health 9/29/2010
UNIVERSITY OF IOWA, THE $50,000 Grant Trans-NIH Recovery Act Research Support: This application is to provide support for a supervised research career development experience for Dr. David Stoltz in the field of airway cell biology. Dr. Stoltz has completed a combined M.D./Ph.D. program and is currently in the Pulmonary/Critical Care Health and Human Services, Department of / National Institutes of Health 8/02/2010
JOHNS HOPKINS UNIVERSITY, THE $202,950 Grant Trans-NIH Recovery Act Research Support: Herpesviruses encode a ubiquitin-specific cysteine protease that was only recently discovered and determined to be incorporated into infectious virus as an active enzyme. Although it is embedded within the amino end of a well-characterized virion tegument Health and Human Services, Department of / National Institutes of Health 7/19/2010
WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY $507,780 Grant Trans-NIH Recovery Act Research Support: Adenovirus infection results in a robust stimulation of the inflammatory and adaptive arms of the immune system. Initiation of the antiviral immune response depends on early recognition by sentinel immune cells such as macrophage and dendritic cells. Once Health and Human Services, Department of / National Institutes of Health 7/26/2010
RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL $11,542,415 Contract : The Research Institute at Nationwide Children's Hospital has been awarded a contract to provide support services to serve as a Biospecimen Core Resource(s) (BCRs) site for receiving tissue and data from the multiple the Tissue Source Site (TSS) networks Health and Human Services, Department of / National Institutes of Health 9/24/2010
TRUSTEES OF INDIANA UNIVERSITY $150,822 Grant Trans-NIH Recovery Act Research Support: The complex causes of substance abuse disorders, including the use of multiple substances (polyuse) and co-occurrence with mental health problems (comorbidity) require scientists from both the biomedical and social sciences to pool their expertise to unde Health and Human Services, Department of / National Institutes of Health 9/20/2010
UNIVERSITY OF CALIFORNIA, DAVIS $137,115 Grant Trans-NIH Recovery Act Research Support: The purpose of this supplemental submission to the California National Primate Research Center (CNPRC) Base Operating Grant is to enable large-scale sharing of existing nonhuman primate pathology data (histologic images, gross photos and associated biolo Health and Human Services, Department of / National Institutes of Health 8/09/2010
CHILD TRENDS INC $79,400 Grant Trans-NIH Recovery Act Research Support: The goal of the proposed research is to examine differences in well-being, in terms of academic achievement, mental health, and substance use, for adult offspring growing up with nonresident versus resident fathers and to examine whether nonresident fathe Health and Human Services, Department of / National Institutes of Health 8/26/2010
BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE $839,093 Grant Trans-NIH Recovery Act Research Support: PUBLIC HEALTH RELEVANCE STATEMENT: The goal of this proposal is to identify causal genetic variants that affect celiac disease risk, a common disease with a population prevalence of almost 1% (1:133) in the United States. Celiac disease is associated with Health and Human Services, Department of / National Institutes of Health 9/30/2010
QIAGEN INC. $26,575 Contract : Biological Materials Health and Human Services, Department of / National Institutes of Health 9/13/2010
VIRGINIA COMMONWEALTH UNIVERSITY $74,750 Grant Trans-NIH Recovery Act Research Support: The overall goal of this proposal is to determine the biological role of RAI1 in the cell. The studies proposed seek to initiate development of zebrafish as model for studying gene dosage requirements for rai1, with a focus on overexpression of rai1. The Health and Human Services, Department of / National Institutes of Health 8/25/2010
BROAD INSTITUTE, INC., THE $847,500 Grant Trans-NIH Recovery Act Research Support: The Broad Institute performs high-throughput large scale biology with academic collaborators from across the country, investigating a wide variety of biological systems. In this proposal the Broad Institute core small molecule screening group is requestin Health and Human Services, Department of / National Institutes of Health 7/15/2010
ILLUMINA, INC. $1,228,423 Contract : ARRA H1N1 (flu) Large Equipment Request: This requirement will purchase equipment that will support ongoing Influenza projects within the Division of Intramural Research, NIAID (National Institute of Allergy and Infectious Diseases). The deliverables incl Health and Human Services, Department of / National Institutes of Health 9/27/2010
UNIVERSITY OF MARYLAND $121,824 Grant Trans-NIH Recovery Act Research Support: In response to and in anticipation of seasonal changes in natural light, many animals manifest marked seasonal changes in physiology and behavior, such as those related to hibernation, breeding and migration. Although humans have increasingly (but far fro Health and Human Services, Department of / National Institutes of Health 9/20/2010
YALE UNIVERSITY $399,089 Grant Trans-NIH Recovery Act Research Support: The immunologic events that lead to the development of Type 1 diabetes mellitus (T1DM) are not clearly defined. Understanding the immunologic events that lead to beta cell destruction is an important goal of mechanistic studies since they are likely to su Health and Human Services, Department of / National Institutes of Health 9/30/2010
YALE UNIVERSITY $111,120 Grant Trans-NIH Recovery Act Research Support: The gap between basic research advances and new clinical insights and treatments remains a critical obstacle to progress in the field of alcoholism research. This translational neuroscience mission is the enduring focus of the Center for the Translational Health and Human Services, Department of / National Institutes of Health 8/20/2010
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $2,500,000 Grant Trans-NIH Recovery Act Research Support: The IMMERSE in CER (Innovative Mentoring and MPH Education in Research and Scientific Excellence in Comparative Effectiveness Research) Program will provide training and mentoring in skills essential to conducting comparative effectiveness research (CER), Health and Human Services, Department of / National Institutes of Health 9/28/2010
EMORY UNIVERSITY $77,449 Grant Trans-NIH Recovery Act Research Support: Emory Parkinson's Disease Environmental Research Center (PD-CERC) Supplement 1: Identification of compounds that enhance vesicular storage of dopamine and other monoamines The vesicular monoamine transporter 2 (VMAT2) in monoamine neurons (nerve cells) pa Health and Human Services, Department of / National Institutes of Health 7/01/2010
WASHINGTON STATE UNIVERSITY $73,464 Grant Trans-NIH Recovery Act Research Support: The long term goal of this project has been to understand the role of Sertoli cells in spermatogenesis. To achieve this goal, previous studies focused on gene expression and hormonal response of murine Sertoli cells and the interactions of the somatic cel Health and Human Services, Department of / National Institutes of Health 7/07/2010
PARKER TIDE CORP. $71,580 Contract : Scientific Consultant on ARRA Funded Projects under the Common Fund Health and Human Services, Department of / National Institutes of Health 8/10/2010
OREGON HEALTH & SCIENCE UNIVERSITY $78,814 Grant Trans-NIH Recovery Act Research Support: Much is known about the hormonal mechanisms controlling ovarian development. More recently, a major focus of attention in the field has been the identification of regulatory pathways that, operating within the ovarian microenvironment, contribute to the a Health and Human Services, Department of / National Institutes of Health 7/27/2010
MEDICAL COLLEGE OF WISCONSIN, INC., THE $44,100 Grant Trans-NIH Recovery Act Research Support: The parent grant was awarded to study the molecular mechanisms of activation of NHE-1, which is an electroneutral sodium-proton exchanger expressed in nearly every mammalian cell, and which is responsible for regulation of cell growth, intracellular pH, a Health and Human Services, Department of / National Institutes of Health 9/28/2010
UNIVERSITY OF ROCHESTER $414,803 Grant Trans-NIH Recovery Act Research Support: The focus of the parent proposal (Understanding the Generation of HIV Broadly Neutralizing Antibodies) is to define the critical aspects of the cellular processes leading to the generation, or lack thereof, of BNA. This is vital as the success of any vacc Health and Human Services, Department of / National Institutes of Health 7/26/2010
JOSLIN DIABETES CENTER, INC. $99,183 Grant Trans-NIH Recovery Act Research Support: Development Genes and the Origin of Fat. The development of obesity depends in part on the balance between food intake and energy utilization; but also on the balance between white adipose tissue, which is the primary site of energy storage, and brown ad Health and Human Services, Department of / National Institutes of Health 12/14/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA $62,000 Grant Trans-NIH Recovery Act Research Support: The overall goal of this research is to understand the sperm function regulation by calcium, cyclic nucleotides and ion channels at the molecular level. This proposal focuses on the roles of a sperm tail ion channel (CatSper1) we discovered. CatSper1 from Health and Human Services, Department of / National Institutes of Health 7/19/2010
BAYLOR COLLEGE OF MEDICINE $161,313 Grant Trans-NIH Recovery Act Research Support: This project aims to understand the mechanisms how immune complex-mediated signals modulate immunity and overcome age-associated immune deficiency. The success of this project will lead to a novel vaccination strategy to provide better protection to immun Health and Human Services, Department of / National Institutes of Health 9/13/2010
WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION $420,758 Grant Trans-NIH Recovery Act Research Support: This supplemental proposal is designed to enhance and fully develop the capabilities of the WVU Genomics Core Facility to support translational research studies by both clinical and basic science investigators at West Virginia University. The proposal bu Health and Human Services, Department of / National Institutes of Health 9/09/2010
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $110,658 Grant Trans-NIH Recovery Act Research Support: The establishment of an intimate interaction between the long retinal pigment epithelium (RPE) microvilli and the mature photoreceptor outer segments is essential for vision. The RPE performs highly specialized, unique functions essential for homeostasis Health and Human Services, Department of / National Institutes of Health 7/01/2010
NORMATEC INDUSTRIES LP $199,956 Grant Trans-NIH Recovery Act Research Support: Pneumatic Medicine: A Transformative Treatment for Diabetic Peripheral Neuropathy Health and Human Services, Department of / National Institutes of Health 9/30/2010
VIRION SYSTEMS INC $139,139 Grant Trans-NIH Recovery Act Research Support: The respiratory tract is a major portal for pathogens. The bronchoalveolar macrophage, positioned at the mucosal surface, recognizes pathogen associated molecular patterns (PAMPs) through pattern recognition receptors (PRRs). A family of mammalian PRRs, T Health and Human Services, Department of / National Institutes of Health 9/29/2010
REGENTS OF THE UNIVERSITY OF COLORADO, THE $467,942 Grant Trans-NIH Recovery Act Research Support: We request funds to purchase a supercontinuum STED microscope. The STED (STimulated Emission Depletion) microscope, invented by Stefan Hell, is the first light microscope to break the Abbi diffraction limit. Abbi's barrier, a fundamental law of physics, s Health and Human Services, Department of / National Institutes of Health 7/01/2010
ARIZONA STATE UNIVERSITY $114,116 Grant Trans-NIH Recovery Act Research Support: 'The original (parent) study is focused on (a) establishing and delivering a readily-administered polestriding exercise therapy protocol in individuals with PD, (b) quantitative evaluation of the neuroadaptive effects of polestriding exercise intervention Health and Human Services, Department of / National Institutes of Health 8/11/2010
UNIVERSITY OF CALIFORNIA, IRVINE $328,505 Grant Trans-NIH Recovery Act Research Support: Nulliparas comprise about 40% of pregnant women in the United States. Because no information is available from previous pregnancy outcomes to guide assignment of risk of mitigating interventions, adverse pregnancy outcomes in nulliparas are especially unp Health and Human Services, Department of / National Institutes of Health 7/08/2010
CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU $392,500 Grant Trans-NIH Recovery Act Research Support: The overall objective of this application is to investigate the oxidation/reduction-regulated cellular and molecular mechanisms providing the homeostatic control of interleukin (IL)- 4-mediated signal transduction, gene expression, and immune responses. T Health and Human Services, Department of / National Institutes of Health 7/06/2010
UNIVERSITY OF WISCONSIN SYSTEM $74,250 Grant Trans-NIH Recovery Act Research Support: Alcohol is a potent neurotoxicant and prenatal alcohol exposure is a leading cause of neurodevelopmental disability. One affected population is the neural crest. Our past work found that clinically relevant ethanol exposures (20-80 mM) cause neural crest Health and Human Services, Department of / National Institutes of Health 9/03/2010
UNIVERSITY OF CALIFORNIA, DAVIS $165,341 Grant Trans-NIH Recovery Act Research Support: The insights gained from the Year 1 studies have caused us to adjust our exposure paradigm. Specifically, studies during Year 2 of the parent grant will evaluate fetuses exposed to continuous, levels of BPA that better model current human exposure levels Health and Human Services, Department of / National Institutes of Health 8/28/2010
REGENTS OF THE UNIVERSITY OF MINNESOTA $514,772 Grant Trans-NIH Recovery Act Research Support: The overall aim of this project is to clarify the relationship between neuronal activity in the internal segment of the globus pallidus (GPi) and the development, phenotypic distribution and severity of dystonic movements in patients with primary generali Health and Human Services, Department of / National Institutes of Health 9/01/2010
WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY $302,103 Grant Trans-NIH Recovery Act Research Support: The ability of experimentalists to perturb biological systems has traditionally been limited to rigid pre- programmed protocols or more flexible, but reflex constrained, operator-controlled protocols. In contrast, 'real-time control' allows the researcher Health and Human Services, Department of / National Institutes of Health 9/29/2010
TETRAGENETICS, INC $177,636 Grant Trans-NIH Recovery Act Research Support: Novel methods for high-level expression of aglycosylated or fully glycosylated monoclonal antibodies in a Tetrahymena thermophila manufacturing platform. Health and Human Services, Department of / National Institutes of Health 7/28/2010
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $834,674 Grant Trans-NIH Recovery Act Research Support: In this supplement application, there are two specific aims, one regarding validation of data to increase pace and confidence of variant calls and one regarding the rapid implementation of a tool created for The Cancer Genome Atlas (TCGA) data disseminati Health and Human Services, Department of / National Institutes of Health 9/17/2010
FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, THE $103,750 Grant Trans-NIH Recovery Act Research Support: In this one-year ARRA administrative supplement, we plan to conduct the various experiments to determine 1) the dose-response effect of radiation on the survival of experimental animals to obtain LD50 dose of radiation; 2) whether early administration of Health and Human Services, Department of / National Institutes of Health 9/20/2010
SCRIPTPRO USA INC $926,499 Contract : Pharmacy Outpatient Information and Dispensing System Health and Human Services, Department of / National Institutes of Health 8/20/2010
UNIVERSITY OF WISCONSIN SYSTEM $252,151 Grant Trans-NIH Recovery Act Research Support: Iron deficiency is the most common human nutritional deficiency disease. Recent estimates of the prevalence of iron deficiency ranges from 2% to 22% of Americans depending on age and gender. Since iron deficiency impairs work output due to muscle dysfunct Health and Human Services, Department of / National Institutes of Health 8/01/2010