Listing all stimulus spending by amount, in descending order. Return to National Institutes of Health page
Amount refers to both the amount of stimulus funding going toward the project and the face value of the loan.
| Recipient | Amount | Type | Description | Federal Dept./Agency | Date |
|---|---|---|---|---|---|
| EMORY UNIVERSITY | $54,403 | Grant | Trans-NIH Recovery Act Research Support: Even though major advances have been made in the past decade with respect to understanding the genetics, environmental and immune dysregulation in IBD, the etiopathogenesis of IBD is poorly understood. It is envisaged that this investigation will define t | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| EMORY UNIVERSITY | $174,056 | Grant | Trans-NIH Recovery Act Research Support: PREDOCTORAL TRAINING PROGRAM IN GENETICS Opportunities in the fields of genetics and molecular biology in academia, government, and in the private sector have increased with the explosion of genetic information and the potential to use this information fo | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| EMORY UNIVERSITY | $150,000 | Grant | Trans-NIH Recovery Act Research Support: Efficacy and Mechanisms of GLN Dipeptide in the SICU (GLND trial): The purpose of this supplement is to accelerate the tempo of research in the current NIH/NIDDK-funded trial U01 DK069322 (the GLND study) by adding an additional study site at the Universi | Health and Human Services, Department of / National Institutes of Health | 9/10/2009 |
| EMORY UNIVERSITY | $776,051 | Grant | Trans-NIH Recovery Act Research Support: Although AlzheimerG??s Disease (AD) is an aggressive and devastating dementia that has an increased frequency with age and is one of the most common neurodegenerative diseases, it is remarkably difficult to diagnose with certainty, particularly in the ear | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| EMORY UNIVERSITY | $965,006 | Grant | Trans-NIH Recovery Act Research Support: Streptococcus pyogenes, the group A streptococcus (GAS) is an important human pathogen that causes many types of disease, ranging in severity from strep throat to severe invasive disease and streptococcal toxic shock syndrome. By elucidating the regulatio | Health and Human Services, Department of / National Institutes of Health | 5/22/2009 |
| EMORY UNIVERSITY | $64,001 | Grant | Trans-NIH Recovery Act Research Support: Parent Grant Title: Cellular Targets of Polyomavirus Transforming Proteins The expertise my laboratory has developed and the many reagents we have created have placed us in an outstanding position to help elucidate the roles and regulation of the enzyme, | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $711,356 | Grant | Trans-NIH Recovery Act Research Support: Despite the considerable advancements in our understanding of the mechanisms of acute and chronic pain, inadequate pain relief remains a major issue in chronic pain. Cannabinoid agonists acting on cannabinoid receptors (CBR) 1 and 2 have shown great promi | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| EMORY UNIVERSITY | $947,179 | Grant | Trans-NIH Recovery Act Research Support: Current theories of drug abuse view addiction as a disease, but inevitably, the element of volitional choice will remain one of the key components of the illness. The issue boils down to this: why does an individual choose to use drugs even when they kn | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| EMORY UNIVERSITY | $700,002 | Grant | Trans-NIH Recovery Act Research Support: Sickle cell nephropathy is a common complication of sickle cell disease that affects both children and adults, and may lead to kidney failure. The mechanisms that cause kidney damage in sickle cell disease are not well understood. We will study kidney dam | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| EMORY UNIVERSITY | $49,338 | Grant | Trans-NIH Recovery Act Research Support: TITLE: Role of Syk and Rac2 in regulation of HIF1alpha and neovascularization Postnatal neovascularization plays a critical role in pathogenesis of numerous diseases e.g. diabetic retinopathy, tissue remodeling upon injury, rheumatoid arthritis and tumor | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| EMORY UNIVERSITY | $706,021 | Grant | Trans-NIH Recovery Act Research Support: HIV incidence among men who have sex with men (MSM) continues to rise in the United States, and over 50% of new US HIV infections in 2006 were among MSM. A recent CDC analysis suggests that over half of HIV transmissions among MSM are from main partners. | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| EMORY UNIVERSITY | $59,178 | Grant | Trans-NIH Recovery Act Research Support: Effects of mGluR2/3 Activation on Cue-Induced Cocaine Relapse in Squirrel Monkeys Despite substantial efforts, there are currently no FDA-approved pharmacotherapies available for the treatment of cocaine abuse or dependence. A prominent feature of cocain | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| EMORY UNIVERSITY | $192,292 | Grant | Trans-NIH Recovery Act Research Support: Title: SUPPORT OF YERKES NATIONAL PRIMATE RESEARCH CENTER One of the central goals of the Yerkes National Primate Research Center is to provide educational and training opportunities. The Center is actively involved in training and continuing education | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| EMORY UNIVERSITY | $99,984 | Grant | Trans-NIH Recovery Act Research Support: A C.elegans model for EPEC & EHEC Pathogenesis. The project is designed to understand evolutionarily conserved mechanisms by which the immune system detects pathogens. Here we use the model genetically maleable nematode Cenorhabditis elegans to determine | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| EMORY UNIVERSITY | $273,118 | Grant | Trans-NIH Recovery Act Research Support: 'Nox4 and cardiac fibrosis'. Congestive heart failure is a major cause of hospitalization (over 500,000 admissions per year) and affect over 5 million patients in US. In the current application we will study the mechanism of development and progression of | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| EMORY UNIVERSITY | $99,901 | Grant | Trans-NIH Recovery Act Research Support: This supplemental request encompasses activities of the Emory Epithelial Pathobiology Research Development Center core facilities and will update and add to essential components of the Morphology/Image Analysis Core (Core B) and Cell Culture and Monoclona | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| EMORY UNIVERSITY | $1,649,526 | Grant | Trans-NIH Recovery Act Research Support: The scope of the CTOTC-02 collaborative encompasses unique barriers to successful kidney transplantation in children. Over the past forty years, the use of increasingly potent immunosuppressive drugs has lessened the risk for acute rejection (AR) and subs | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| SEATTLE BIOMEDICAL RESEARCH INSTITUTE | $30,740 | Grant | Trans-NIH Recovery Act Research Support: This grant is providing summer and academic research experiences for high school students, college students and science educators in health-related scientific research. The research experiences were in support of a parental NIH grant that investigates how | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE | $144,810 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this research is to develop a comprehensive model of the perception of 3D object motion. The recovery of object motion in a 3D environment is important for perceptual tasks such as the detection and avoidance of collisions and performing in | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $927,000 | Grant | Trans-NIH Recovery Act Research Support: Bicarbonate is a vital component of secretions from exocrine glands such as salivary glands, the pancreas, the duodenum, reproductive organs, sweat glands and the airways. It plays a critical role in numerous physiological functions such as digestion, and | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF TEXAS AT ARLINGTON | $209,257 | Grant | Trans-NIH Recovery Act Research Support: The overall objective of the grant is to develop a multifunctional image guided surgical (MIGS) platform to perform delicate and intricate surgeries. The MIGS platform integrates a high resolution depth-resolved imaging technique know as optical coherence | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE | $499,998 | Grant | Trans-NIH Recovery Act Research Support: Over the past five years the Tulane National Primate Research Center (TNPRC) has successfully developed and expanded its specific pathogen free (SPF) rhesus monkey breeding colony. By the end of the current funding period the U24 SPF colony will have grow | Health and Human Services, Department of / National Institutes of Health | 8/24/2009 |
| TEXAS BIOMEDICAL RESEARCH INSTITUTE | $524,290 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project proposed for supplemental funding is the same as that of the parent grant (U42 RR016024): to increase the nation's capacity to produce Indian-origin rhesus monkeys (Macaca mulatta) that are specific pathogen-free (SPF) for herpes | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| EMORY UNIVERSITY | $58,452 | Grant | Trans-NIH Recovery Act Research Support: My award title is HIV-INDUCED 5-LIPOXYGENASE: ROLE IN HIV-RELATED PULMONARY ATERIAL HYPERTENSION. My research aim is to determine whether HIV-1 increases the susceptibility of infected individuals to develop the non-infectious pulmonary vasculature disord | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| EMORY UNIVERSITY | $772,650 | Grant | Trans-NIH Recovery Act Research Support: Design of new treatment agents for drug abuse The development of effective medications for the treatment of drug addiction disorders is of great importance to society. Great advances have been made in the treatment of many CNS diseases that were previou | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| EMORY UNIVERSITY | $172,186 | Grant | Trans-NIH Recovery Act Research Support: Tuberculosis (TB) is an enormous global public health problem including in the independent country of Georgia, a former Soviet republic, which has high rates of TB including drug-resistant TB (MDR- and XDR-TB). This ARRA award is a supplement (U.S. Globa | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| EMORY UNIVERSITY | $54,000 | Grant | Trans-NIH Recovery Act Research Support: PROLIFERATIVE RESPONSES TO ENTERIC PATHOGENS IN INTESTINAL TISSUES Funding for the K01 parent grant was provided to study the protein Kruppel-like factor 5 (KLF5), a protein that promotes cell division/proliferation in the intestines. Preliminary evidenc | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| EMORY UNIVERSITY | $100,000 | Grant | Trans-NIH Recovery Act Research Support: REGULATION OF RAT RENAL INNER MEDULLARY FUNCTION. The major goal of the parent grant, 5R01DK041707, is to test two hypotheses: 1?? vasopressin rapidly increases UT-A1 accumulation in the apical plasma membrane; and 2?? vasopressin regulates UT-A1 retrieva | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| UNIVERSITY OF MASSACHUSETTS | $90,543 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement is under parent grant 5R01DK064902-05, Epidemiology of Stress and GDM among Latina Women. The overall goal of the administrative supplement is to achieve more quickly the goals of the project through the hiring of additional | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF CALIFORNIA, SANTA BARBARA | $600,810 | Grant | Trans-NIH Recovery Act Research Support: A nanomicelle-forming amphiphile PTS has been identified that allows for several Pd- and Ru-catalyzed cross-couplings to take place in water as the only solvent, and at room temperature, in high isolated yields. The new processes include Heck, Suzuki, Son | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF MARYLAND | $1,322,801 | Grant | Trans-NIH Recovery Act Research Support: Early childhood temperament, particularly behavioral inhibition, is seen as an expression of a child's biologically based negative reactivity to novelty and threat. Behavioral inhibited children have difficulty with peer interactions and exhibit withdrawa | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER | $140,920 | Grant | Trans-NIH Recovery Act Research Support: Candida albicans is an opportunistic fungal pathogen that is able to survive as a commensal organism in several anatomically distinct sites. In compromised hosts, the manifestations of invasive infection caused by C. albicans vary based upon the particula | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $270,000 | Grant | Trans-NIH Recovery Act Research Support: With the support of the Framework Program in Global Health, Dartmouth will undertake The Dartmouth Global Health Initiative: Growing a Multidisciplinary Framework program to develop a coordinated multidisciplinary curriculum and new educational opportunit | Health and Human Services, Department of / National Institutes of Health | 5/06/2009 |
| EMORY UNIVERSITY | $804,807 | Grant | Trans-NIH Recovery Act Research Support: POLARITY OF REDOX CONTROL AND RISK OF INJURY IN THE ALVEOLAR EPITHELIUM There is a significant difference in the concentrations and redox potentials between the fluid lining the epithelial surface and plasma for reduced and oxidized components of the an | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| EMORY UNIVERSITY | $178,808 | Grant | Trans-NIH Recovery Act Research Support: Title: Patients' Experiences of Emergency Research: The PEER Study There is a critical need for clinical research on treatment of acute neurological conditions such as traumatic brain injury, seizures, and stroke. The National Institute of Neurological Di | Health and Human Services, Department of / National Institutes of Health | 6/15/2009 |
| EMORY UNIVERSITY | $426,250 | Grant | Trans-NIH Recovery Act Research Support: Title: Towards the development of a novel treatment for epilepsy. The voltage-gated sodium channels SCN1A, SCN2A, SCN3A, and SCN8A are key regulators of neuronal excitability in the central nervous system (CNS). Mutations in SCN1A, SCN2A, and SCN3A are a | Health and Human Services, Department of / National Institutes of Health | 7/19/2009 |
| EMORY UNIVERSITY | $1,515,743 | Grant | Trans-NIH Recovery Act Research Support: Increasingly available and inexpensive high-throughput DNA sequencing holds great promise for biomedical research, but informatics challenge block the full realization of the potential of this transformative technology. In particular progress is limited b | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| EMORY UNIVERSITY | $775,000 | Grant | Trans-NIH Recovery Act Research Support: HIV vaccine strategies have not yet succeeded in generating broadly neutralizing antibody responses in humans. A limited number of broadly neutralizing human monoclonal antibodies against HIV have been identified and have been the subject of intensive stu | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| EMORY UNIVERSITY | $154,813 | Grant | Trans-NIH Recovery Act Research Support: General Magnitude Representation in Infancy: Testing the Associations among Space, Number, and Time Abstract: Space, number, and time provide fundamental sources of information by which we (and other animals) structure experience in the world. Althoug | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UMDNJ-ROBERT WOOD JOHNSON MEDICAL SCHOOL | $860,173 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad challenge area (04), clinical research, and specific challenge topic 05-CA-104, comparative effectiveness research on cancer treatment. One in six American men will be diagnosed with prostate cancer in their lifetime. Wh | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| EMORY UNIVERSITY | $2,202,768 | Grant | Trans-NIH Recovery Act Research Support: Transplantation is the preferred method of treatment for many forms of end-stage organ failure. Current therapy in clinical transplantation relies on potent non-specific immunosuppressive drugs to inhibit rejection. While short-term results have improved | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| EMORY UNIVERSITY | $809,920 | Grant | Trans-NIH Recovery Act Research Support: Function of the Gamma HV68 M2 Antigen This is a revised competing renewal of an R01 grant to characterize the function of the murine gammaherpesvirus 68 (MHV68) M2 antigen. Gamma-herpesviruses are associated with the development of lymphoproliferative d | Health and Human Services, Department of / National Institutes of Health | 7/28/2009 |
| EMORY UNIVERSITY | $29,797 | Grant | Trans-NIH Recovery Act Research Support: Cellular Signaling and Kidney Function This supplemental funding application requests support for 4 undergraduate summer students for 2 years to participate in the research described in our program project grant P01-DK61521. This PPG is a joint endea | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| EMORY UNIVERSITY | $99,820 | Grant | Trans-NIH Recovery Act Research Support: The parent project entitled The Role of Leptin in Liver Fibrogenesis was competetively renewed on April 1, 2008 for four years. This application was funded via the R01 investigator-initiated mechanism for four years. The central hypothesis of the parent g | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| EMORY UNIVERSITY | $107,042 | Grant | Trans-NIH Recovery Act Research Support: Fostering Global Health Opportunities fro Emory and Its Partners Incorporating state of the art information and communication technologies (ICT) into Framework educational programs and activities is critical if Emory University is to remain among the lead | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $852,500 | Grant | Trans-NIH Recovery Act Research Support: Emerging and established viral diseases take an enormous toll on human health. Current treatment approaches are unlikely to halt epidemic spread of many viruses, notably HIV-1, due to prohibitive costs of treatment (i.e. access), compliance issues, rapid | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $629,839 | Grant | Trans-NIH Recovery Act Research Support: This project will develop and disseminate a key computational resource for integration of Near-Infrared Spectroscopy (NIRS) into Magnetic Resonance Imaging (MRI). The way to seamlessly use spectroscopy within MRI is to allow a flexible flow from MR image | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE | $48,000 | Grant | Trans-NIH Recovery Act Research Support: With this application for an Administrative Supplement, we seek to implement state-of-the-art technology to test hypotheses stated in Specific Aim 1 of our proposal (1R01AI080302: Molecular Regulation of HIV-1 Assembly, Release, and Cell to Cell Transmiss | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $118,206 | Grant | Trans-NIH Recovery Act Research Support: X-linked spinal and bulbar muscular atrophy (SBMA, Kennedy's disease) is an inherited neuromuscular disorder characterized by lower motor neuron degeneration. SBMA is caused by CAG/polyglutamine (polyQ) repeat expansions in the human androgen receptor (A | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| EMORY UNIVERSITY | $97,684 | Grant | Trans-NIH Recovery Act Research Support: CTL ESCAPE AND REVERSION IN LINKED PAIRS Recent studies have demonstrated that HIV immune escape follows a predictable mutational path in response to an individualG??s genetic environment, specifically an individualG??s HLA alleles. Since immune escape f | Health and Human Services, Department of / National Institutes of Health | 7/23/2009 |
| EMORY UNIVERSITY | $775,000 | Grant | Trans-NIH Recovery Act Research Support: Cardiac hypertrophy and the subsequent heart failure (HF) cause more than 260,000 deaths a year in The United States. Award Title:FUNCTIONAL COUPLING BETWEEN Ito AND Ica IN CARDIOMYOCYTES Recent studies demonstrated that the pathological increase of intra | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| EMORY UNIVERSITY | $966,462 | Grant | Trans-NIH Recovery Act Research Support: In recent years, reactive oxygen species (ROS) have been shown to have critical roles in normal vascular function and the pathogenesis of vascular disease. These molecules have profound effects on vascular smooth muscle cell (VSMC) growth, migration and | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| EMORY UNIVERSITY | $155,000 | Grant | Trans-NIH Recovery Act Research Support: Vitamin D Status in Pulmonary Fibrosis Idiopathic pulmonary fibrosis is a diffuse interstitial lung disease of unknown etiology characterized by chronic inflammation and progressive fibrosis and carries a 3-year, 50% mortality. Currently, there are no eff | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| EMORY UNIVERSITY | $426,250 | Grant | Trans-NIH Recovery Act Research Support: The Role of JAM-A in Regulation of Intestinal Antigen Presenting Cells and Inflammation Numerous observations have suggested that inflammatory bowel disease is a multifactorial process encompassing at least three major interacting elements: environmental | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| EMORY UNIVERSITY | $76,771 | Grant | Trans-NIH Recovery Act Research Support: Each year, approximately five million people die from injuries, and millions more develop temporary or permanent disability, exacting a profound toll on the individual, family and society. Injury places a significant burden on countries with limited resou | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| EMORY UNIVERSITY | $100,392 | Grant | Trans-NIH Recovery Act Research Support: Ultrasonic Tissue-Typing-Guided Prostate Brachytherapy. The purpose of this supplemental proposal is to increase the target number of patients in our clinical study by 40% (from 100 to 140), strengthening the statistical power of our parent grant. In ad | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| UNIVERSITY OF MASSACHUSETTS | $669,529 | Grant | Trans-NIH Recovery Act Research Support: This program will continue to study fundamental structural properties of the cell nucleus that support biological control and are disrupted in leukemia and metastatic breast cancer. We will gain insight into components of nuclear organization that can be | Health and Human Services, Department of / National Institutes of Health | 9/02/2009 |
| EMORY UNIVERSITY | $199,950 | Grant | Trans-NIH Recovery Act Research Support: Title: THE ROLE OF MOUSE ARL13B IN CELL DIVERSIFICATION Cilia play well-established roles in motility and cell signaling in the mammalian nervous system. Our current understanding of how the neuroepithelium gives rise to specific neurons while maintain | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| EMORY UNIVERSITY | $433,692 | Grant | Trans-NIH Recovery Act Research Support: Title: The Role Of Leukocyte Sequestration In The Control Of Viral Infections Abstract In the period immediately following infection, many viruses cause a transient, type I interferon-dependent lymphopenia. The reason that mammalian hosts adopt such a str | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| EMORY UNIVERSITY | $232,500 | Grant | Trans-NIH Recovery Act Research Support: Transplant Tolerance in Non-human primates. This program project grant seeks to develop novel immunomodulatory strategies to induce immune tolerance after transplantation. Immune tolerance is defined as the acceptance of an allogeneic allograft without re | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| FOX CHASE CANCER CENTER | $1,389,172 | Grant | Trans-NIH Recovery Act Research Support: For the 100 years of its history, Fox Chase Cancer Center (FCCC) has been guided by a singular mission to reduce the burden of human cancer. Its 1904 hospital charter called for 'the study of the cause, treatment and prevention of cancer and for the disse | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| EMORY UNIVERSITY | $162,855 | Grant | Trans-NIH Recovery Act Research Support: Title: Novel VLP vaccines for pandemic influenza virus (The ARRA award was made as a supplement to an ongoing project (AI068003). The 2009 influenza outbreak strain is the result of human infection with a new H1N1 strain of influenza virus containing some | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| APERYS | $58,062 | Grant | Trans-NIH Recovery Act Research Support: Administrative supplement for High-Resolution Patterning of Neuron Cultures to Enable High-Throughput Assays Neuronal cell culture is a cornerstone of neuroscience research and is used extensively in studies of brain and behavior. The in vitro environment | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| HARVARD PILGRIM HEALTH CARE INC | $996,280 | Grant | Trans-NIH Recovery Act Research Support: ?Approaches to study the interactions among individual behaviors, social and physical environments, and genetic/epigenetic processes during critical developmental periods.? Decades of animal physiology experiments unequivocally show that perturbations du | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE | $106,246 | Grant | Trans-NIH Recovery Act Research Support: Chronic kidney disease (CKD) has become an important public health challenge in the United States. CKD is a major risk factor for end-stage renal disease (ESRD), cardiovascular disease (CVD), and premature death. Understanding novel risk factors for the p | Health and Human Services, Department of / National Institutes of Health | 9/02/2009 |
| EMORY UNIVERSITY | $1,246,164 | Grant | Trans-NIH Recovery Act Research Support: 'FMRP-mediated translation regulation in neuronal development ' The fragile X mental retardation protein (FMRP) binds mRNA and microRNA, is associated with polyribosomes, and is localized in dendrites and axons. Hence, FMRP is thought t | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| EMORY UNIVERSITY | $426,250 | Grant | Trans-NIH Recovery Act Research Support: 'Identification of localized miRNAs for neuronal development and plasticity'. This research will advance our understanding of the critical importance played by miRNAs in local protein synthesis underlying neuronal development, which may be altered in dise | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| EMORY UNIVERSITY | $500,000 | Grant | Trans-NIH Recovery Act Research Support: FEI TRANSMISSION ELECTRON MICROSCOPE WITH TOMOGRAPHY CAPABILITY The award is for an electron microscope, an instrument that can be used for new discoveries in biology or in the study of small structures. There is a dedicated group of scientists who will u | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| EMORY UNIVERSITY | $135,625 | Grant | Trans-NIH Recovery Act Research Support: Title: Supplement to Functional approach to communication sound processing in mouse auditory cortex Early views of the adult auditory system describe it as a static processor of sound. Ample evidence now demonstrates though that the adult auditory syste | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| EMORY UNIVERSITY | $37,975 | Grant | Trans-NIH Recovery Act Research Support: STRUCTURE FUNCTION STUDIES ON INTESTINAL EPITHELIAL JAM Our proposed studies encompass detailed cell-biological approaches that have resulted in major advances in understanding the molecular basis of how JAM-A signals to regulate cell migration and perme | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| EMORY UNIVERSITY | $61,738 | Grant | Trans-NIH Recovery Act Research Support: Cellular Responses to Radiation and Other Types of Damage Radiation is responsible for mutation and genomic instability as a result of DNA strand nicks and breaks and misreplication of damaged DNA. This damage if not correctly repaired is responsible for | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| EMORY UNIVERSITY | $264,184 | Grant | Trans-NIH Recovery Act Research Support: Excitation-contraction coupling in human ventricle development Postnatal changes in the mammalian heart make it difficult to extrapolate pharmacological and surgical therapies from adults to infants. Excitation-contraction coupling is the method b | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| EMORY UNIVERSITY | $291,952 | Grant | Trans-NIH Recovery Act Research Support: This is an administrative supplement for R21 HL093665 (PI, V. Vaccarino), entitled G?Sex Differences in Myocardial Ischemia Triggered by Emotional Factors after MI.G? One third to two thirds of patients with CHD have myocardial ischemia that is induced by | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $170,636 | Grant | Trans-NIH Recovery Act Research Support: Molecular Imaging of G-Protein Coupled Receptors for Drug Development Supplemental support is requested that will enable the research on structural studies of G-protein-coupled receptors to be accelerated and improved. The support for a postdoc | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| EMORY UNIVERSITY | $771,552 | Grant | Trans-NIH Recovery Act Research Support: The cutaneous microcirculation plays a central role in a range of skin diseases that are characterized by epidermal hyperproliferation or cutaneous inflammation. Many of these diseases are typified by increased vascular permeability, leading to cutaneous | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $14,015 | Grant | Trans-NIH Recovery Act Research Support: Administrative Supplement - The purpose of the supplement is to pursue the knockdown of Siglec-5 in chimpanzee T cells using small interfering RNA. The student will work an experienced postdoc in the lab to optimize this knockdown first in model cells, | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE | $287,417 | Grant | Trans-NIH Recovery Act Research Support: Hypertension is a leading cause of death and disability affecting over 50 million people in the United States and responsible for 200,000 deaths annually. Because hypertension and associated cardiovascular diseases are prevalent in Louisiana, Tulane Healt | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $120,488 | Grant | Trans-NIH Recovery Act Research Support: The prospect of prophylactov treatment of a large number of people with small pox antiviral agents raises the possibility of a significant degree of toxicity to the kidney and other organs. Since the basolateral Oast and other apical multispecific transpo | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| EMORY UNIVERSITY | $155,000 | Grant | Trans-NIH Recovery Act Research Support: Impact of Video Viewing on Infant Learning: Using Baby Signs as an Experimental Approach The American Academy of Pediatrics recommends that children under two refrain from watching television or videos on the grounds that infant viewing is potentially h | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| UMDNJ-ROBERT WOOD JOHNSON MEDICAL SCHOOL | $793,695 | Grant | Trans-NIH Recovery Act Research Support: The Personal Responsibility and Work Opportunity Reconciliation Act (PRWORA) of 1996, often referred to as welfare reform, ended entitlement to welfare benefits under Aid to Families with Dependent Children (AFDC) and replaced AFDC with Temporary Assistan | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF ROCHESTER | $803,526 | Grant | Trans-NIH Recovery Act Research Support: Cardiovascular disease is the number one killer of Americans, claiming over 500,000 lives annually. These deaths occur when the fibrous cap of an atherosclerotic plaque ruptures in the later stages of the disease. Current screening tests for the diagnosis | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| EMORY UNIVERSITY | $477,754 | Grant | Trans-NIH Recovery Act Research Support: The title of this award: REPAIR OF CLUSTERED DNA DAMAGES. Melanoma is the most fatal form of skin cancer. Despite much research has been directed to identify the etiological factors that lead to melanoma formation, it is still not clear what factors ot | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| EMORY UNIVERSITY | $109,620 | Grant | Trans-NIH Recovery Act Research Support: ADMIN SUPPLEMENT - HER-2/IGF-IR CROSSTALK AND HERCEPTIN The her2 gene is overexpressed in approximately 30% of metastatic breast cancers, and is associated with rapid disease progression and poor survival. Herceptin, a recombinant humanized anti-HER2 mon | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| EMORY UNIVERSITY | $43,358 | Grant | Trans-NIH Recovery Act Research Support: Currently, the most accurate experiment approach to quantitatively measure gap junction mediated biochemical coupling is the LAMP assay. The LAMP method is noninvasive and offers excellent temporal resolution. The dyes used in LAMP have high ultraviolet ( | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| EMORY UNIVERSITY | $310,000 | Grant | Trans-NIH Recovery Act Research Support: Neutrophil interactions with intestinal epithelial cells The etiology of human inflammatory bowel disease (IBD) includes both aberrant leukocyte responses and epithelial barrier dysfunction. Junctional Adhesion Molecule (JAM) family of proteins have been | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| EMORY UNIVERSITY | $169,829 | Grant | Trans-NIH Recovery Act Research Support: The purpose of the funding is to provide employment for on additional resident in an already existing veterinary training program, thus increasing the return on investment from the parent R25 supported program, while offering a new employment opportunity | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| EMORY UNIVERSITY | $261,084 | Grant | Trans-NIH Recovery Act Research Support: TRAINING IN SYSTEMS AND INTEGRATIVE BIOLOGY: NEUROSCIENCE: This award will support three addditional outstanding predoctoral students in the interdepartmental Graduate Program in Neuroscience at Emory University for the next two years. The objective of th | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| EMORY UNIVERSITY | $50,000 | Grant | Trans-NIH Recovery Act Research Support: This award is an administrative supplement for a Career Transition Award from the Center to Reduce Cancer Health Disparities at NCI to promote the advancement of minority scientist towards independence and research on health disparities related issues. Th | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE | $240,800 | Grant | Trans-NIH Recovery Act Research Support: The focus of the parent grant is to study the role of ?? T cells in the immune response to infection with Borrelia burgdorferi. Despite our knowledge of the existence of ?? T cells for 25 years, we still know very little regarding their contribution to t | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| EMORY UNIVERSITY | $599,998 | Grant | Trans-NIH Recovery Act Research Support: The Atlanta Clinical and Translational Science Institute's (ACTSI) community engagement efforts strive to increase the capacity of communities to participate in clinical and translational research. ACTSI's Community Engagement and Research Program (CERP), | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $99,445 | Grant | Trans-NIH Recovery Act Research Support: This grant provided summer research experiences for two teachers, one graduate student, and two undergraduate students in health-related scientific research. Project NCE (no Cost Extension)ended 11/30/10. | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $310,149 | Grant | Trans-NIH Recovery Act Research Support: Function and Regulation of the Human Splicing Factor SC35 was designed to study the role of SR proteins in regulated RNA processing, focusing on the following 3 specific aims: 1. Analyze the splicing program during heart development 2. Determine the funct | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $79,997 | Grant | Trans-NIH Recovery Act Research Support: Group B Streptococcus (GBS), the leading cause of invasive bacterial infections in human newborns, and a common cause of ascending placental infection triggering premature delivery or spontaneous abortion. In studies published in Blood (2009), we showed | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $844,791 | Grant | Trans-NIH Recovery Act Research Support: Infections with RSV are one of the major causes of viral lower respiratory tract illness. Protection against RSV may be achieved with an efficient vaccination strategy that induces neutralizing humoral immunity and a Th1-dominant cellular response and tha | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF CALIFORNIA, SANTA BARBARA | $647,662 | Grant | Trans-NIH Recovery Act Research Support: The primary long-term goal of this ongoing project is to elucidate the nature of the underlying neural mechanisms responsible for the reinforcing and motivational properties of drugs of abuse. Previous work in this field has concentrated on cocaine's rein | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $173,963 | Grant | Trans-NIH Recovery Act Research Support: In response to NOT-OD-09-058 (NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications), the Norris Cotton Cancer Center (NCCC) requests CCSG developmental funds to promote cancer comparative effectiveness research throug | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| EMORY UNIVERSITY | $426,250 | Grant | Trans-NIH Recovery Act Research Support: Schizophrenia biomarkers discerned by cellular networks in DiGeorge syndrome. To understand the causes of schizophrenia we should ultimately consider its genetic underpinnings and developmental course (i.e. from the prenatal period though adulthood). In r | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| EMORY UNIVERSITY | $82,339 | Grant | Trans-NIH Recovery Act Research Support: The elongation of transcripts by RNA polymerase II is a complex process dependent upon nucleotide substrate levels, elongation factors, and co-transcriptional events such as splicing. Mutations in genes encoding elongation factor SI I (TFIIS), other elong | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| EMORY UNIVERSITY | $155,000 | Grant | Trans-NIH Recovery Act Research Support: Dietary Inorganic Phosphate as a Target for Nutritional Intervention in Cancer It is becoming increasingly apparent that diet can have profound effects on functional genomics. However, this area of research has only begun to be exploited for therapeutic b | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| EMORY UNIVERSITY | $290,159 | Grant | Trans-NIH Recovery Act Research Support: This award titled: 'NUCLEAR MAGNETIC RESONANACE SPECTROSCOPY BASED METABOLOMICS' is funded under the American Recovery and Reinvestment Act of 2009 (ARRA) to develop a novel metabolomics approach that may improve the early diagnosis of Alzheimer's disease | Health and Human Services, Department of / National Institutes of Health | 5/18/2009 |
| EMORY UNIVERSITY | $397,691 | Grant | Trans-NIH Recovery Act Research Support: This project will investigate the efficacy of UBS109, a water soluble nuclear factor kappa B (NF-kB ) antagonist structurally related to curcumin, the principal curcuminoid of the Indian curry spice turmeric, to block CNS and behavioral changes in an anim | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| EMORY UNIVERSITY | $743,447 | Grant | Trans-NIH Recovery Act Research Support: Factor VIII (fVIII) is the protein that is missing or deficient in patients with hemophilia A. The development of inhibitory antibodies (Abs) to fVIII currenlty is considered the most significant complication in the management of patients with hemophilia | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| EMORY UNIVERSITY | $79,332 | Grant | Trans-NIH Recovery Act Research Support: The mammalian intestinal epithelium is a dynamic system in which cell proliferation is closely linked to differentiation and cell death. Studies have identified several important pathways such as Wnt, Notch, BMP and hedgehog that are involved in maintaini | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| EMORY UNIVERSITY | $31,000 | Grant | Trans-NIH Recovery Act Research Support: This summer student research will support and accelerate aim-3 of the parent grant to identify the cause of exaggerated glutamate receptor signaling at synapses in a mouse model of fragile x syndrome. This research will provide students with training and | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| EMORY UNIVERSITY | $27,900 | Grant | Trans-NIH Recovery Act Research Support: Detection of Left Ventricular Dyssynchrony by Cross-Correclation Analysis The purpose of the funding was to create a position for a student to obtain research experience in the summer and fall of 2009. The funding allowed the student to perform added ana | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| EMORY UNIVERSITY | $250,625 | Grant | Trans-NIH Recovery Act Research Support: The title of the award is: Comparison of B Cell Differentiation in Mice and Humans. Our previous studies indicated that human B cells, but not mouse B cells, preferentially express immunoglobulin Fc Receptor-Like (FCRL) transmembrane receptors that have a | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| EMORY UNIVERSITY | $94,006 | Grant | Trans-NIH Recovery Act Research Support: We are proposing a predoctoral training program in Biostatistics in Genetics, Immunology, and Neuroimaging (BGIN). In this program, students will learn to develop statistical and computational innovations applied in one of three areas of concentration: 1. | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| EMORY UNIVERSITY | $486,623 | Grant | Trans-NIH Recovery Act Research Support: SPF Breeding Colonies at the Yerkes NPRC G?? Supplement Support to enable us to better characterize the MHC region of the specific pathogen free (SPF) colony of rhesus macaques housed at the Yerkes National Primate Research Center by using a two-fold app | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| EMORY UNIVERSITY | $998,826 | Grant | Trans-NIH Recovery Act Research Support: Atlanta Clinical and Translation Science Institute (UL1): Supplement to the Translational Technologies and Resources Program to Advance Innovation through Imaging The Translational Technologies and Resources (TTR) Program of the Atlanta Clinical and Tran | Health and Human Services, Department of / National Institutes of Health | 9/05/2009 |
| TEXAS A & M RESEARCH FOUNDATION | $83,543 | Grant | Trans-NIH Recovery Act Research Support: In the United States (US) ticks transmit more vector borne disease agents than any other vector arthropod. Limitations associated with current acaricide based tick control strategies that threaten the future sustainability of tick borne illnesses containm | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| YALE UNIVERSITY | $1,524,000 | Grant | Trans-NIH Recovery Act Research Support: The Yale Program in Cellular Neuroscience, Neurodegeneration and Repair (CNNR) was co-founded by the PI and Co-PI four years ago with the goal of linking basic research in neuronal cell biology with efforts to advance pathophysiological understanding of n | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| HEBREW REHABILITATION CENTER FOR AGED, INC. | $400,000 | Grant | Trans-NIH Recovery Act Research Support: This award supports the Harvard Older AmericansIndependence Center (OAIC), which has been funded over the past 2 years with ARRA support. Over the previous funding period the Center generated over 928 research papers and trained over 50 new investigators | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF MASSACHUSETTS | $820,000 | Grant | Trans-NIH Recovery Act Research Support: Over the next several years, the number of older individuals in the U.S. population will increase dramatically. Associated with this aging population, will be a large surge in the number of cases of age-associated illnesses. Understanding the aging proc | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| YALE UNIVERSITY | $826,221 | Grant | Trans-NIH Recovery Act Research Support: Mental and physical functioning have major implications for the quality of life of older individuals. We plan to examine a largely unexplored social psychological factor that may benefit older individuals longterm functioning: the age stereotypes that ind | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| UNIVERSITY OF TENNESSEE | $740,000 | Grant | Trans-NIH Recovery Act Research Support: Rheumatoid arthritis is a chronic inflammatory disease of diarthrodial joints. This systemic disease is characterized by chronic synovitis, sustained by an antigen-driven immune process against one or more proteins found in cartilage. Although several ant | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| YALE UNIVERSITY | $1,172,590 | Grant | Trans-NIH Recovery Act Research Support: Treatment of breast cancer with hormonal therapy and more recently trastuzumab (Herceptin) has led the field of cancer treatment in the use of companion diagnostics to select patients most likely to respond to targeted therapies. However, the currently us | Health and Human Services, Department of / National Institutes of Health | 8/05/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $1,260,288 | Grant | Trans-NIH Recovery Act Research Support: Emotion Regulation and Depression in Breast Cancer Survivorship: Both in individuals living with cancer and in the general population, the experience of clinical depression exacts a profound psychological, physical, and economic toll. Little research has | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| UNIVERSITY OF TENNESSEE | $780,989 | Grant | Trans-NIH Recovery Act Research Support: The homeostatic balance between proliferation and apoptosis is essential for the intestinal epithelium to function as a physiological and structural barrier. Intestinal epithelial cells have a high rate of cell turnover accompanied by an equally high rate | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $2,593,750 | Grant | Trans-NIH Recovery Act Research Support: The changing demographics of developed nations underscores the need for regenerative medicine approaches to combat the clinical and financial burden of degenerative diseases. The basic understanding of how tissues are normally maintained by their resident | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| HEALTH RESEARCH, INC. | $674,247 | Grant | Trans-NIH Recovery Act Research Support: Summary description of the project that matches the Award: Our data indicate that the human prostate-derived Ets transcription factor (PDEF) plays an essential role in tumor suppression via downregulation of the expression of antiapoptotic protein survivi | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $487,200 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this project is to develop enabling computational tools for IGART and to show the potential clinical impact of the new paradigm of IGART. The underlying hypothesis of this work is that IGART will greatly reduce the uncertainty in beam targe | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| BAYLOR COLLEGE OF MEDICINE | $637,028 | Grant | Trans-NIH Recovery Act Research Support: Purpose: Identify virus and host factors important in polyomavirus SV40 infections and cancer development. Abstract: Human cancer viruses establish persistent infections in their hosts. We hypothesize that the risk of viral induced cancer is dependent o | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $634,952 | Grant | Trans-NIH Recovery Act Research Support: Based on our recent findings, we hypothesize that chromatin coregulators such as ANCCA is a key mediator of specific AR function in the conversion of prostate cancer to the hormone-refractory state. To test our hypothesis, we propose to establish the role | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $449,138 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to define the mechanisms by which crosstalk between the insulin-like growth factor 1 receptor (IGF1R) and vascular endothelial growth factor (VEGF) receptor pushes oral squamous cell carcinoma (OSCC) cells to metastatic progres | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $709,650 | Grant | Trans-NIH Recovery Act Research Support: The overarching goal of this project is to understand two important aspects of epigenetic control during medulloblastoma formation, namely the difference between cancer stem cells and bulk tumor, and the role of DNA methylation dependent gene silencing in | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | $611,564 | Grant | Trans-NIH Recovery Act Research Support: Molecularly targeted agents against receptor tyrosine kinases (RTK), particularly the antiangiogenic agents (AAs), have caused a paradigm shift in cancer chemotherapy. These agents target tumor angiogenic mechanisms (sprouting of new blood vessels) that a | Health and Human Services, Department of / National Institutes of Health | 5/28/2009 |
| ILLINOIS INSTITUTE OF TECHNOLOGY | $385,637 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this funded project is to optimally design synthetic hydrogel scaffolds of poly(ethylene glycol) diacrylate (PEGDA) that promote rapid vascularization (angiogenesis) which is essential for the clinical success of implantable tissue engineer | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $2,566,864 | Grant | Trans-NIH Recovery Act Research Support: Descriptive Title: G?Understanding the mechanisms to correct the development of the immune system using stem cell therapy in children with inherited immune deficiency.G? The central hypothesis of the Program is that the age of the hematopoietic graft and | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF MASSACHUSETTS | $664,155 | Grant | Trans-NIH Recovery Act Research Support: Data resulting from our prior and current research, support the suggestion that the elmiric acids (EMA), which are carboxy containing analogs of the endocannabinoid anandamide, are potential anti-inflammatory agents (Burstein et al., 2007). It was observe | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $1,167,052 | Grant | Trans-NIH Recovery Act Research Support: The aim of this two-year 'Grand Opportunities' ('GO') proposal is to construct a detailed and comprehensive profile of the molecular biology of cardiac function in a hibernating mammal. In compliance with 'GO' program requirements the proposed project is | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $4,136,888 | Grant | Trans-NIH Recovery Act Research Support: Patients with an acute coronary syndrome (ACS) and comorbid depression have a 2-fold higher risk for recurrent ACS and mortality, worse quality of life, and higher costs of care than nondepressed ACS patients. The strength of these findings prompted the A | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $1,345,823 | Grant | Trans-NIH Recovery Act Research Support: Infection of children with Shiga toxin (Stx) producing Escherichia coli (STEC), primarily a food and waterborne aquired disease, is the leading cause of hemolytic-uremic syndrom (HUS) in the US. There is no specific treatment to prevent or ameliorate HUS. | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| UNIVERSITY OF ILLINOIS | $1,042,363 | Grant | Trans-NIH Recovery Act Research Support: Characterization of Therapeutic human monoclonal antibodies against SARS-CoV. Aim-1. /To characterize the relative binding affinities and specificities of human monoclonal antibodies against SARS-CoV. /*/ /We will identify a subset of HmAbs with differ | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $388,089 | Grant | Trans-NIH Recovery Act Research Support: Patients with active ulcerative colitis (UC) despite of a therapy with 5-aminosalicylates and steroids represent a clinical challenge, since the alternatives in medical therapy are considerably fewer compared to those for patients with active Crohn's dise | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | $2,195,148 | Grant | Trans-NIH Recovery Act Research Support: Three of the critical issues in modern cancer research and evolutionary theory include (a) an understanding of the progression of mutations over time, (b) an identification of the cell of origin of these tumors, (c) and the differential response of cancer | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $674,761 | Grant | Trans-NIH Recovery Act Research Support: ARRA - Socioeconomic Disparities in Young Adult Health In the United States, large and persistent health disparities exist across the life course. Reducing these disparities is a top priority for policymakers and the public. Of particular importance, f | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| WOMEN & INFANTS HOSPITAL OF RHODE ISLAND | $10,830 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this supplement is to provide funding support for students seeking careers in heath science related research with a particular interest in neurodevelopment and cellular and molecular biological mechanisms of perinatal Hypoxic-ischemic brain | Health and Human Services, Department of / National Institutes of Health | 7/09/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO | $593,833 | Grant | Trans-NIH Recovery Act Research Support: Developing germ cells must be in intimate contact with Sertoli cells for the successful completion of spermatogenesis. This cellular interaction is facilitated by specialized actin-based adherens junctional complexes known as ectoplasmic specializations ( | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| NORTHWESTERN UNIVERSITY | $5,310,858 | Grant | Trans-NIH Recovery Act Research Support: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of premenopausal women, affecting ~7% of this population. It has major reproductive and metabolic morbidities across the lifespan, including markedly increased prevalence rates of obes | Health and Human Services, Department of / National Institutes of Health | 7/31/2009 |
| MOREHOUSE SCHOOL OF MEDICINE, INC., THE | $593,496 | Grant | Trans-NIH Recovery Act Research Support: Follicular development and differentiation, key to female reproduction, are sequential events that are tightly regulated by balanced cell proliferation, survival and cell death. Previously we reported the prohibitins, PHB1 and REA, as important mediators | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $102,208 | Grant | Trans-NIH Recovery Act Research Support: Award Title: Characterization of a protein translocase in the pathogen Trichomonas vaginalis. Purpose of the research: To identify and characterize members of a protein translocase in the hydrogenosome of Trichomonas vaginalis. These studies could even | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF TENNESSEE | $666,000 | Grant | Trans-NIH Recovery Act Research Support: In previous work we created congenic strains carrying the DBA/2IBG (D2) region for alcohol preference on chromosome 2, on an otherwise C57BL/6IBG (B6) background. Recently, we have done the construction and testing of interval specific congenic recombinan | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $765,430 | Grant | Trans-NIH Recovery Act Research Support: Identification of Genetic Modifiers of Anthrax Lethal Toxin Induced Pathophysiology Virulence of Bacillus anthracis is associated with production of a bipartite protein exotoxin called lethal toxin (LT). While our understanding of the in vitro interaction | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| YALE UNIVERSITY | $51,396 | Grant | Trans-NIH Recovery Act Research Support: Both healthy and pathological aging entail some degree of cognitive and neural decline. Executive functions appear to be particularly affected by aging (Hasher and Zacks, 1988). Executive function has traditionally been associated most strongly with the p | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| YALE UNIVERSITY | $118,144 | Grant | Trans-NIH Recovery Act Research Support: MicroRNAs (miRNAs) constitute a novel class of gene regulatory elements with important roles in the control of gene expression and development in plants and animals. miRNAs are endogenous, small non-coding RNAs which inhibit gene expression by base pairin | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| UNIVERSITY OF MASSACHUSETTS | $92,824 | Grant | Trans-NIH Recovery Act Research Support: The award is a Ruth L. Kirschstein National Research Service Award Individual Postdoctoral Fellowship. The title of the work is 'Genomic Variability of Cytomegalovirus in a Clinical Setting'. The purpose of the fellowship is develop a better understand | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF ARKANSAS SYSTEM | $145,000 | Grant | Trans-NIH Recovery Act Research Support: Title: Significance of Pituitary Leptin to Gonadotropes Pituitary leptin changes in a cyclic manner that indicates it may facilitate or permit the secretion of gonadotropins. There are parallel reductions in pituitary leptin and LH during food deprivat | Health and Human Services, Department of / National Institutes of Health | 4/27/2009 |
| SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | $1,034,246 | Grant | Trans-NIH Recovery Act Research Support: RNA interference (RNAi) is a widespread gene-silencing phenomenon initiated by a double-stranded RNA that is converted into small interfering RNAs (siRNAs). Although the detailed mechanism whereby siRNA silences its target gene expression is not understo | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $965,219 | Grant | Trans-NIH Recovery Act Research Support: Familial episodic ataxia (EA) syndromes are rare and heterogeneous (EA1-EA7 to date) monogenic disorders, the study of which has illuminated previously unrecognized but important roles of ion channels and transporters in neuronal and cerebellar function. | Health and Human Services, Department of / National Institutes of Health | 9/20/2009 |
| UNIVERSITY OF MASSACHUSETTS | $821,354 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of the proposed research is to reveal the physiological functions and in vivo mechanisms of G protein-coupled receptor (GPCR) endocytosis and postendocytic trafficking. GPCRs are the largest family of membrane receptors that receive se | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| YALE UNIVERSITY | $130,400 | Grant | Trans-NIH Recovery Act Research Support: Many men with prostate cancer will be affected by side effects of hormonal therapy. The impact of hormonal therapy for prostate cancer on cognitive function, a major determinant of quality of life, remains unclear. This study proposes to use brain imaging | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $1,253,111 | Grant | Trans-NIH Recovery Act Research Support: For the past 20 years, we have studied the genetic underpinnings of hormonal factors leading to hypertension (HTN) in the HyperPATH cohort. From these studies, we have identified several associations between single nucleotide polymorphic (SNP) markers on | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $740,625 | Grant | Trans-NIH Recovery Act Research Support: High serum levels of low density lipoprotein (LDL) are associated with atherosclerosis, the leading cause of death in the USA. The long term goal of this proposal is to develop new treatments that lower LDL levels and alleviate cardiovascular disease. LDL | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| YALE UNIVERSITY | $395,450 | Grant | Trans-NIH Recovery Act Research Support: The proposed studies of redox sites in photosystem II address fundamental aspects of catalysis that are ubiquitous in metabolic mechanisms of metalloenzymes common to different classes of organisms from bacteria to humans (e.g., P-450s, peroxidases and ox | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $973,684 | Grant | Trans-NIH Recovery Act Research Support: Title: - p63-Dependent Checkpoints in Oocytes.- This project is to define at the molecular level a mechanism that prevents birth defects. In brief, we have discovered a female-specific quality control process operating directly in oocytes that determines | Health and Human Services, Department of / National Institutes of Health | 7/28/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $1,306,662 | Grant | Trans-NIH Recovery Act Research Support: Adolescent Health Literacy: Improving Use of Preventive Health Services in order to to enhance adolescent health literacy, increasing teens 'capacity to access and use their insurance and the current health care system, so they can become empowered health | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF TENNESSEE | $869,393 | Grant | Trans-NIH Recovery Act Research Support: Our preliminary data indicate ischemic hearts from rats have a transient decrease in protein phosphatase 2a (PP2a) activity, and an increase in phosphorylation of phospholamban, ERK and AKT. The decrease in PP2a activity occurs concomitant with demethylat | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $997,188 | Grant | Trans-NIH Recovery Act Research Support: Our award captures the challenge area (06) 'Enabling Technologies,' to address the specific challenge topic 06-AG-101 Neuroscience Blueprint: Development of non-invasive imaging approaches or technologies that directly assess neural activity. This award e | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| LOYOLA UNIVERSITY | $401,311 | Grant | Trans-NIH Recovery Act Research Support: The overall purpose of this award is to determine how respiratory viruses cause inflammation. By identifying host factors leading to inflammation upon virus infection, novel therapies to reduce the extent of viral disease may be developed. Additionally, | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $426,875 | Grant | Trans-NIH Recovery Act Research Support: Tropical malaria, caused by the parasite Plasmodium falciparum, is responsible for up to three million deaths each year. Since the parasite develops resistance against most clinically available drugs, novel antimalarial drugs are urgently needed. Glucose- | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $408,271 | Grant | Trans-NIH Recovery Act Research Support: Immunological memory at the mucosa must be carefully balanced to ensure long-term protection from re-current infection without excessive immune activation which could lead to chronic inflammation and disease. The intestinal mucosa is a unique niche where | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF KENTUCKY | $403,525 | Grant | Trans-NIH Recovery Act Research Support: Infants are particularly susceptible to respiratory infections which have been attributed to an immature and naive immune system that is characterized by suboptimal antigen presentation and a T helper cell bias toward Th2-type cytokines. However, little i | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $171,764 | Grant | Trans-NIH Recovery Act Research Support: Upregulation of the renin-angiotensin system and increased vasoconstrictive response to angiotensin II (AngII) are observed during hypertension in pregnancy (HTN-Preg) and preeclampsia. Although the renin- angiotensin system is upregulated during normal p | Health and Human Services, Department of / National Institutes of Health | 5/04/2009 |
| MEHARRY MEDICAL COLLEGE | $146,500 | Grant | Trans-NIH Recovery Act Research Support: The objective of this study is to determine the relationship between the severity of emphysema in COPD patients and abnormality in the expression of key mediators of retinoid action in the lungs | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $431,750 | Grant | Trans-NIH Recovery Act Research Support: Premature birth is a major public health problem that causes 70-80% of neonatal morbidity and mortality. To address this problem our research focuses on understanding the hormonal control of labor and in particular how the steroid hormone progesterone act | Health and Human Services, Department of / National Institutes of Health | 4/30/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $439,964 | Grant | Trans-NIH Recovery Act Research Support: Preterm birth, small-for-gestational age (SGA) and pregnancy induced hypertension (PIH) are major pregnancy complications that impact the health of the mother and the child, often resulting in admission to the neonatal intensive care unit following delive | Health and Human Services, Department of / National Institutes of Health | 5/11/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $484,340 | Grant | Trans-NIH Recovery Act Research Support: Data on the effects of omega-3 fatty acids (n-3 FA) on cardiovascular risk are inconsistent. Some observational studies and randomized trials have suggested that n-3 FA may lower the risk of sudden cardiac death (SCD) and coronary events, possibly through | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| WAYNE STATE UNIVERSITY (INC) | $909,524 | Grant | Trans-NIH Recovery Act Research Support: Aim 1. We will define the structural and biological basis for the shedding of mRANKL by MT1-MMP. - Aim 1.1. Investigate the structural basis of MT1-MMP shedding of mRANKL; - Aim 1.2. Identify MT1-MMP/mRANKL complexes at the surface of pc cells. Aim 2. We | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $639,104 | Grant | Trans-NIH Recovery Act Research Support: Multiple myeloma (MM) is still incurable B-cell malignancy affecting more than 14,000 Americans annually. Myeloma tumor cells can survive even the most aggressive treatment available today, leading to disease relapses. The long-term goal of this project i | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $1,313,831 | Grant | Trans-NIH Recovery Act Research Support: Our current treatment algorithms provide for treating all patients with advanced colorectal cancer (and in the future, possibly those with stages II and III) with combined chemotherapy and bevacizumab. While the therapeutic benefit has been marked, it has | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| UNIVERSITY OF NEW MEXICO | $617,174 | Grant | Trans-NIH Recovery Act Research Support: Transposase activity was thought to be extinct in humans because DNA movement can be deleterious in higher organisms, resulting in genomic instability and perhaps malignancy. However, we isolated a human transposase protein termed Metnase that had histone | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $651,550 | Grant | Trans-NIH Recovery Act Research Support: Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related death. Novel therapeutic strategies are urgently needed. With this proposal, we are planning to move toward this goal by gaining a better understanding of the molecular networks that | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $639,100 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this research is to help develop improved chemopreventive interventions for colorectal cancer based on molecular targeting of crucial events in colorectal tumorigenesis. Inflammation contributes to colon carcinogenesis. Prostaglandin | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF FLORIDA | $641,285 | Grant | Trans-NIH Recovery Act Research Support: Natural products show outstanding potential as starting point in drug discovery, especially in the quest for anticancer drugs. The research proposed here will explore structure-activity relationships of largazole, a marine natural product that shows nano | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| DUKE UNIVERSITY | $641,358 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this proposal is to develop a novel local drug delivery system for cancer radiotherapy by direct intratumoral administration of a thermally sensitive macromolecule conjugated to a therapeutic radionuclide of interest. Thermally sensiti | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $482,660 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): For over half a century, androgen deprivation therapy (ADT) has been known to have beneficial effects on prostate cancer due to the testosterone dependence of prostate tumor cells, yet its optimal use still remains und | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $664,660 | Grant | Trans-NIH Recovery Act Research Support: Mucus Penetrating Nanoparticles for Early Stage Cervical Cancer: Drugs administered systemically typically reach the cervicovaginal (CV) tract in very low concentrations. As a result, drug therapies for diseases that affect the CV tract typically suffer f | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| THE MEMORIAL HOSPITAL | $1,261,436 | Grant | Trans-NIH Recovery Act Research Support: With approximately 9 million Americans passing through correctional institutions annually and an average daily population of over 2 million, there are multiple opportunities to address the smoking cessation needs of this high risk and underserved populati | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| DUKE UNIVERSITY | $779,806 | Grant | Trans-NIH Recovery Act Research Support: Individuals diagnosed with Attention Deficit Hyperactivity Disorder (ADHD) smoke more than the general population, initiate use at a younger age, and in general report more difficulty trying to quit. Several converging lines of work suggest that the high | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| WASHINGTON UNIVERSITY, THE | $750,369 | Grant | Trans-NIH Recovery Act Research Support: The normal auditory system possesses exquisitely well-adapted processes for extracting behaviorally relevant acoustic signals from the environment, especially under challenging listening conditions such as in the presence of competing signals or backgroun | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| UNIVERSITY OF PITTSBURGH THE | $754,665 | Grant | Trans-NIH Recovery Act Research Support: Stroke is the leading cause of serious long-term disability in the United States. Adults who have strokes in the right side of the brain often 'miss the point' of what they hear, read, or see -- a life-altering problem that can have devastating effects o | Health and Human Services, Department of / National Institutes of Health | 9/02/2009 |
| UNIVERSITY OF MARYLAND | $750,780 | Grant | Trans-NIH Recovery Act Research Support: Human ether a go-go-related gene 1a (HERG1a, Kv11.1) K+ channels play a critical role in maintaining the fundamental cardiac rhythm. The significance of HERG1a channels is that they are the central component of the rapid delayed-rectifier K+ channel (IKr) | Health and Human Services, Department of / National Institutes of Health | 6/21/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $1,410,090 | Grant | Trans-NIH Recovery Act Research Support: The leading causes of Type 2 diabetes and prediabetes are being overweight or obese and being sedentary. Diabetes and prediabetes have adverse effects on parameters of cardiac and peripheral vascular structure and function that precede clinical manifestat | Health and Human Services, Department of / National Institutes of Health | 6/21/2009 |
| NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC. | $1,552,066 | Grant | Trans-NIH Recovery Act Research Support: Heart failure has reached epidemic proportions in the United States and is responsible for nearly 500,000 deaths each year. The majority of heart failure cases is now the result of infarction-induced left ventricular (LV) remodeling. The lack of well-esta | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| GEORGIA HEALTH SCIENCES UNIVERSITY RESEARCH INSTITUTE, INC. | $735,000 | Grant | Trans-NIH Recovery Act Research Support: Hypertension and the associated renal and cardiovascular complications are a serious health problem in the Unites States. Approximately 65% of hypertensive patients do not have their blood pressure controlled and women are more likely than men to have unc | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| WAKE FOREST UNIVERSITY | $120,387 | Grant | Trans-NIH Recovery Act Research Support: A decrement in spatial learning ability in normal aging has consistently been correlated with blunted receptor signaling mediated through the muscarinic and metabotropic glutamate receptor-G1q/11 signaling transduction system. The role of G1q/11-mediated | Health and Human Services, Department of / National Institutes of Health | 4/29/2009 |
| TEXAS TECH UNIVERSITY SYSTEM | $135,579 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Leishmania parasites cause a spectrum of devastating diseases known as leishmaniasis. A critical step in Leishmania infection is the differentiation from replicative, non-virulent procyclics to non-replicative, highly | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) | $156,000 | Grant | Trans-NIH Recovery Act Research Support: Kingella kingae is a fastidious gram-negative coccobacillus of the Neisseriaceae family and is a normal inhabitant of the human oropharyngeal flora. This bacterium belongs to HACEK group and can cause infective endocarditis. Recently, as the result of imp | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $176,000 | Grant | Trans-NIH Recovery Act Research Support: Upon bacterial infection, host cells release chemicals that damage the bacterial DNA. Such damage, if left unrepaired, leads to bacterial death. Recombination-based DNA repair proteins, specifically the RecBCD and AddAB helicase-nucleases, are excellent t | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $525,000 | Grant | Trans-NIH Recovery Act Research Support: Eukaryotic DNA is compacted through the formation of a nucleoprotein complex known as chromatin. The primary protein components of this complex are the core histones H2A, H2B, H3 and H4. The core histones form an octameric complex around which DNA wraps t | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $412,500 | Grant | Trans-NIH Recovery Act Research Support: Cardiovascular disease is the leading cause of death, and one of the primary causes of disability worldwide. Atherosclerosis is the primary contributor to cardiovascular disease. About one-half of the deaths that can be attributed to cardiovascular diseas | Health and Human Services, Department of / National Institutes of Health | 6/19/2009 |
| UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) | $429,000 | Grant | Trans-NIH Recovery Act Research Support: Significant gender differences in the prevalence of cardiovascular disease have been demonstrated. The risk of developing cardiovascular disease is considerably lower in pre-menopausal females than in age-matched males, whereas after menopause, the rate o | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF ILLINOIS | $286,626 | Grant | Trans-NIH Recovery Act Research Support: The major barrier to use of autologous EPCs in regenerative vascular medicine is the low number and limited trans-differentiation potential. It is necessary to develop an efficient method to increase the number and/or potency of autologous EPCs. As of now | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $412,722 | Grant | Trans-NIH Recovery Act Research Support: There is considerable public and professional concern that the two most widely prescribed stimulants for youth with attention-deficit/hyperactivity disorder (ADHD), mixed salts of amphetamine (MAS) and methylphenidate (MPH), may increase the risk of strok | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $424,875 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Mood disorders represent a class of devastating illnesses that have profound impact upon individuals, families, communities, employers, and health care systems. While many medications and therapies exist for the treatm | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| THE VANDERBILT UNIVERSITY | $425,876 | Grant | Trans-NIH Recovery Act Research Support: Bipolar disorder (BPD) is among the 10 leading causes of disability in the developed world. The etiology of the disease is unknown and treatment options are based on either serendipitous discoveries of mood stabilizing effects of certain substances, or on | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| UNIVERSITY OF PITTSBURGH THE | $416,625 | Grant | Trans-NIH Recovery Act Research Support: Depression is a leading cause of disability worldwide. Yet, despite the discovery of clinically-effective antidepressants over fifty years ago, the biological mechanisms of the illness remain mostly uncharacterized. As a result, very few new drugs are dev | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $441,700 | Grant | Trans-NIH Recovery Act Research Support: This proposal aims to develop an 18F-labeled agonist PET probe for in vivo quantification of the G-protein coupled high affinity serotonin 1A (5-HT1A) receptors in baboon. We have two major motivations for developing an 18F labeled 5-HT1A receptor agonist | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $424,875 | Grant | Trans-NIH Recovery Act Research Support: GABA modulation and negative affect in psychosis Schizophrenia frequently presents with clinically significant negative affect. In addition to co-morbid depression and anxiety disorders (up to 60 O/O), patients show high levels of trait negative affectivi | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $999,956 | Grant | Trans-NIH Recovery Act Research Support: The overarching goal of this proposal is to characterize the mechanisms through which SDB may lead to alterations in glucose metabolism and determine the putative role of ET-1. To accomplish our goals, we will employ a combination of unique observational | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| PUGET SOUND BLOOD CENTER PROGRAM | $996,583 | Grant | Trans-NIH Recovery Act Research Support: With this award our goal is to use biomarkers of platelet factor 4 (PF4), platelet activation and immune response, along with clinical factors to identify patients at risk of heparin/PF4 antibody formation. Patients who undergo surgery requiring cardiopu | Health and Human Services, Department of / National Institutes of Health | 11/25/2009 |
| TRIPLE RING TECHNOLOGIES, INC. | $960,499 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (04): Clinical Research and specific Challenge Topic 04-HD-102*: Development of Pediatric Medical Devices. Radiation dose in pediatric cardiac interventions is a serious | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: Over the past quarter, we have published one paper titled Preclinical derivation and imaging of autologously transplanted canine induced pluripotent stem cells (Lee AS et la, J Biological Chemistry 2011). We have also successfully generated another porci | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $998,030 | Grant | Trans-NIH Recovery Act Research Support: The goals of this project are: 1) Form a Cardiovascular Risk Reduction Learning Community; 2) Electronically collect and analyze data on trajectories of hypertension and LDL-cholesterol control, antihypertensive and hypolipidemic drug prescription and ful | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $943,677 | Grant | Trans-NIH Recovery Act Research Support: We will identify means to effectively disseminate, adopt and use an established, evidence-based worksite health promotion/injury reduction program for firefighters in 12 departments (~1200 total firefighters) in the Pacific NW. The program is research-bas | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $965,438 | Grant | Trans-NIH Recovery Act Research Support: The goal of this proposal is to identify auto antigens in new autoimmune encephalopathies in human patients, and to determine the effects of patient auto antibodies on neurons and synapses. The proposal thus has clinical and basic neuroscience components | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF MASSACHUSETTS | $999,599 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (15): Translational Science and specific Challenge Topic, 15-NS-104: Early-stage Therapy Development. Amyotrophic lateral sclerosis (ALS, Lou Gehrigs disease) is a devastating neurodegenerative condition | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| KAISER FOUNDATION HOSPITALS | $1,005,372 | Grant | Trans-NIH Recovery Act Research Support: When stroke patients leave the acute hospital, they travel care paths through various post-acute care sites such as inpatient rehabilitation hospital, skilled nursing facility or home health. However, their families and providers do not have a way to asse | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $989,593 | Grant | Trans-NIH Recovery Act Research Support: This application is directed to Challenge Area 14, Stem cells, and Specific Challenge Topic 14- NS-101, Reverse engineering human neurological disease: generation of stem cells from control and patient populations. The recent development of induced plurip | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $949,844 | Grant | Trans-NIH Recovery Act Research Support: Highly specialized professional antigen presenting cells are distributed throughout the skin and include epidermal Langerhans cells (LCs) and dermal dendritic cells (DCs). Our laboratory established some unique properties of cutaneous DCs. We discovered | Health and Human Services, Department of / National Institutes of Health | 7/23/2009 |
| UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) | $780,000 | Grant | Trans-NIH Recovery Act Research Support: Infections with antibiotic resistant bacteria are increasing at an alarming rate. Antibiotic resistance is a particular problem in patients with blood stream infections or sepsis, due to the a mortality that rises exponentially as effective treatment is d | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $234,083 | Grant | Trans-NIH Recovery Act Research Support: Induction of allograft tolerance would avoid the need for chronic immunosuppressive therapy with its attendant toxicities. We have recently performed a pilot trial of combined non-myeloabiative bone marrow and kidney transplantation (CKBMT) from related h | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $705,000 | Grant | Trans-NIH Recovery Act Research Support: Fibrocartilaginous tissues are found throughout the musculoskeletal system in regions experiencing substantial levels of both tension and compression during functional loading. These tissues have highly organized, heterogeneous structures that are well su | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| NORTHWESTERN UNIVERSITY | $736,370 | Grant | Trans-NIH Recovery Act Research Support: ACL is the most commonly injured knee ligament in sports-related activities, especially in pivoting sports. ACL injury mechanisms, including factors contributing to the 2-9 times higher incident rate in female athletes than their male counterparts, are st | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| UNIVERSITY OF MISSOURI SYSTEM | $1,571,275 | Grant | Trans-NIH Recovery Act Research Support: Musculoskeletal conditions are exceptionally common and costly to treat. In a 2002 survey of US adults 26% reported back pain and 14% reported neck pain in the previous three months. Expenditures to treat spine conditions alone accounted for at least 9% o | Health and Human Services, Department of / National Institutes of Health | 8/06/2009 |
| YALE UNIVERSITY | $455,125 | Grant | Trans-NIH Recovery Act Research Support: The function of most genes in our genome remains a mystery. In order to determine their function, we must use model systems such as frogs specifically Xenopus. In this proposal, we will create new technologies to determine gene function in Xenopus and the | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $506,742 | Grant | Trans-NIH Recovery Act Research Support: Collaborative R34 grant which is 1/3 CBT(Cognitive Behavioral Therapy) for Anxiety Disorders in Autism: Adapting Treatment for Adolescents. This project involves adapting a promising intervention for elementary school children with Autism Spectrum Disorde | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| YALE UNIVERSITY | $413,750 | Grant | Trans-NIH Recovery Act Research Support: Opportunistic infections are the primary cause of suffering and death in individuals with AIDS. Many of these infections are produced by parasites that rarely affect individuals who are not immunocompromised. Unfortunately, successful combination therapie | Health and Human Services, Department of / National Institutes of Health | 6/11/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: 'Diet and Exercise (DE) Program for Alzheimer Prevention' This project directly addresses three challenge areas: first broad Challenge Area (01) Behavior, Behavioral Change, and Prevention (specific topic 01-AG-102 Neural mechanisms), second broad Chall | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| YALE UNIVERSITY | $998,477 | Grant | Trans-NIH Recovery Act Research Support: This application addresses the broad Challenge Area (08) Genomics, Beyond GWAS 08-DK-102. The overall genetic architecture and pathogenic mechanisms of complex disorders such as Crohn's disease (CD) is incompletely defined at present. Genome-wide associat | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $827,382 | Grant | Trans-NIH Recovery Act Research Support: Despite best intentions in practice and recent innovations, the sciences continue to experience high attrition rates, particularly in studentsG?? first and second years of college and specifically among underrepresented racial minority students. This crit | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF ARKANSAS SYSTEM | $932,085 | Grant | Trans-NIH Recovery Act Research Support: A new non-invasive technology to diagnose preterm labor : Premature delivery accounts for 12% of all births in the United States and is identified as the leading cause of perinatal morbidity and mortality. Despite advancements in medicine and technology, | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $954,988 | Grant | Trans-NIH Recovery Act Research Support: Neuroimmune Factors Mediate the Co-morbid Expression of Enhanced Fear, Alcohol Consumption and Depression in an Animal Model of Post-Traumatic Stress Disorder; This award addresses broad Challenge Area 01-AA-102 Functional Roles of Neuroimmune Factors in | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| YALE UNIVERSITY | $500,000 | Grant | Trans-NIH Recovery Act Research Support: Asthma is characterized by chronic airway inflammation. It is well established that Th2 inflammation and the downstream responses that occur provide much of the underlying basis of asthma pathogenesis. The biologic function of Th2 inflammation is believed | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| BAYLOR COLLEGE OF MEDICINE INC | $429,750 | Grant | Trans-NIH Recovery Act Research Support: Purpose: To aquire state-of-the art flow cytometer. Abstract: Our research at Baylor College of Medicine requiring a four-laser LSRII flow cytometer will specifically study processes within cells allowing us to better understand stem cell therapies, a | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| WESTERN INSTITUTE FOR BIOMEDICAL RESEARCH | $375,300 | Grant | Trans-NIH Recovery Act Research Support: Lithium is an effective drug for the treatment of bipolar disorders, which affect about 2-3% of general population and 4-6% of Veterans. In addition to its long-standing use for the treatment of bipolar disorders, in recent years lithium has been identif | Health and Human Services, Department of / National Institutes of Health | 6/22/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $445,000 | Grant | Trans-NIH Recovery Act Research Support: In humans, telomeres are repeating strings of TTAGGG DNA sequences at both ends of a chromosome. While their complete biological functions remain unclear, it is known that telomere lengths shorten gradually and contribute to senescence, apoptosis, or neo | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $527,806 | Grant | Trans-NIH Recovery Act Research Support: Title: Cntnap2 in a Behavioral Model of Autism Impairments in language, social interaction and behavioral flexibility that together occur in young children comprise the hallmarks of autism spectrum disorder (ASD; Geschwind & Levitt, 2007, Curr Op Neurobi | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF ARKANSAS SYSTEM | $398,750 | Grant | Trans-NIH Recovery Act Research Support: Regulation of caspase-1 by Sod2 in the heart? Apoptosis of cardiomyocytes is increased in human heart failure, and several studies have subsequently suggested that cardiomyocyte apoptosis is a central mechanism in heart failure. The exploratory studies | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| YALE UNIVERSITY | $389,125 | Grant | Trans-NIH Recovery Act Research Support: The molecular mechanism of antipsychotic drug action is not well understood. Several studies have reported the brain region specific induction of DNA-binding proteins (transcription factors, TF) by these drugs. The functional activity of these transcripti | Health and Human Services, Department of / National Institutes of Health | 5/13/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $539,000 | Grant | Trans-NIH Recovery Act Research Support: Therapeutic approach to Autism Spectrum Disorders using TrkB agonists and the molecular mechanisms of TrkB agonist action in human neurons. The overall goal of this proposal is to examine whether TrkB agonist(s) may have therapeutic values for Autism Spec | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF MASSACHUSETTS | $451,636 | Grant | Trans-NIH Recovery Act Research Support: The role of nicotinic receptors in nicotine withdrawal. Nicotine addiction is one of the primary causes of preventable mortality in the world. Withdrawal symptoms that occur after nicotine cessation account for the high incidence of relapse in people at | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| YALE UNIVERSITY | $996,533 | Grant | Trans-NIH Recovery Act Research Support: Genetic architecture of alcohol misuse candidate endophenotypes - Research Area This application addresses broad Challenge Area 03) Biomarker Discovery and Validation; specific Challenge Topic 03-AA-101,Identification of Intermediate Phenotypic Markers o | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| SAN DIEGO STATE UNIVERSITY FOUNDATION | $999,203 | Grant | Trans-NIH Recovery Act Research Support: The study will explore the mechanisms within social networks, including social learning variables (including the presence of models of behavior, social support, self efficacy to control drinking, and others), acculturation, and ecological variables and th | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| SAN DIEGO STATE UNIVERSTIY FOUNDATION | $990,017 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this project is to develop and test brief communications of nutrition facts and alcohol contents that a)individuals can effectively use to monitor their consumption, b)can motivate them to drink moderately, and c)could be required within ba | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF ARKANSAS SYSTEM | $999,998 | Grant | Trans-NIH Recovery Act Research Support: We have conducted a number of in vitro studies concerning the effects of ethanol on modulating the effects of various toll-like receptor ligands on glial activation in both wild-type and knockout mice. We have also generated co-culture paradigms to evalua | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF ARKANSAS SYSTEM | $994,117 | Grant | Trans-NIH Recovery Act Research Support: A SonoKnife for Advanced Cancers. Development of a new technology for non-invasive thermal ablation of superficial head and neck tumors or positive lymph nodes, namely, a SonoKnife, a scanned, line-focused ultrasound thermal therapy system (target tempe | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF MASSACHUSETTS | $999,014 | Grant | Trans-NIH Recovery Act Research Support: Schizophrenia is defined by a lack of a straightforward genetic cause for a very large majority of affected individuals. The prefrontal cortex (PFC), among other brain regions, is thought to be frequently in subjects in schizophrenia, as reflected by its | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| YALE UNIVERSITY | $998,276 | Grant | Trans-NIH Recovery Act Research Support: This application addresses the broad Challenge Area (03) Biomarker Discovery and Validation and specific Challenge topic, 03-MH-101: Biomarkers in Mental Disorders and is entitled: Biomarkers of Suicide Risk in Adolescents and Young Adults: Factors that C | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $923,877 | Grant | Trans-NIH Recovery Act Research Support: This project is entitled Biomarkers for Outcomes in Late-Life Depression (BOLD). This project examines a biomarker-guided treatment for late-life depression which could improve outcomes by rapidly identifying an effective medication for each patient. | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| SOUTHERN ILLINOIS UNIVERSITY | $742,541 | Grant | Trans-NIH Recovery Act Research Support: Bariatric surgery remains the most effective treatment for morbid obesity. In addition, bariatric surgery such as Roux-en Y Gastric Bypass (RYGB) causes the immediate resolution of type-II diabetes in the majority of patients (84%). This remarkable effe | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $161,042 | Grant | Trans-NIH Recovery Act Research Support: More than 10 million cancer survivors are alive in the US today, and there is a need to promote the health and well being of these individuals. While several studies have shown that physical activity is associated with better quality of life in cancer sur | Health and Human Services, Department of / National Institutes of Health | 5/13/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $154,000 | Grant | Trans-NIH Recovery Act Research Support: Layman's abstract: Women with a history of preeclampsia in pregnancy are at reduced risk of breast cancer, especially those who delivered a son, not a daughter, from the pregnancy. Why is this so? We compare hormones in the blood of a group of women who h | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $2,578,698 | Grant | Trans-NIH Recovery Act Research Support: This is a GO application to address 'Mechanisms of Alcohol and Nicotine Co-Dependence' as the area of scientific priority. The GO mechanism is used because this application requires a multi-lab approach to accelerate current and future research. The objec | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF LOUISVILLE | $1,616,440 | Grant | Trans-NIH Recovery Act Research Support: Alcoholic Liver Disease (ALD) remains a major cause of alcohol-related morbidity and mortality. 15-30% of heavy drinkers develop advanced ALD, over 25,000 deaths occur annually related to liver disease, and over 40% of those are attributed to alcoholic c | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $1,946,907 | Grant | Trans-NIH Recovery Act Research Support: Hepatocellular carcinoma (HCC) develops synergistically in HCV-infected patients with alcoholism, and no treatments are available for this devastating complication. Our study reveals the role of TLR4-dependent Nanog+ cancer stem cells (CSCs) in liver onco | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON | $656,488 | Grant | Trans-NIH Recovery Act Research Support: Starting in the 1990's, some physicians began to devote all of their time to the care of hospitalized patients. They are referred to as hospitalists. Our preliminary data suggest a rapid growth in the number of hospitalized older patients cared for nation | Health and Human Services, Department of / National Institutes of Health | 9/02/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $872,500 | Grant | Trans-NIH Recovery Act Research Support: Control of Lymphocyte Homeostasis by Foxo Transcription Factors: Hematopoietic cells constantly turn over. Their rates of division and death determine the steady-state number of cells and size of lymphoid organs. In particular, T lymphocytes are held in a | Health and Human Services, Department of / National Institutes of Health | 5/11/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $941,375 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this project is to generate a detailed understanding of viral meningitis in realtime. Knowledge derived from these studies are expected to foster the development of novel interventions to treat this potentially fatal disorder for whi | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $431,750 | Grant | Trans-NIH Recovery Act Research Support: In the last decade, significant advances have been made toward achieving chemical control of key developmental signal transduction pathways that are frequently corrupted in cancer. Given the promise of these therapeutic strategies and the perils that they | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| BOWLING GREEN STATE UNIVERSITY (INC) | $383,405 | Grant | Trans-NIH Recovery Act Research Support: The goal of the proposed research is to examine the relationship between socioeconomic status (SES), socioeconomic instability and overweight among young children of immigrants and children of natives. This topic is significant because over one in five U. | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $842,908 | Grant | Trans-NIH Recovery Act Research Support: Large epidemiological studies have indicated that genetic factors contribute significantly to the development of coronary atherosclerosis, a major cause of morbidity and mortality in Western countries. Through genome-wide association studies (GWASs), we a | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF NEW ORLEANS | $409,531 | Grant | Trans-NIH Recovery Act Research Support: To support research and other projects that will support fundamental biomedical discovery and translation of that knowledge into effective prevention strategies and new treatments while also providing economic stimulus to the nation. | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| UNIVERSITY OF IOWA, THE | $412,500 | Grant | Trans-NIH Recovery Act Research Support: Mouse models of human psychiatric disorders show that chronic stress can lead to depression. Mice lacking 5HT2CR show signs of stress response, hyperactivity, increased appetite and obesity. 5HT2CR mRNA is edited by two enzymes ADAR1 and ADAR2 that belong | Health and Human Services, Department of / National Institutes of Health | 5/22/2009 |
| SOUTH CAROLINA RESEARCH FOUNDATION | $355,000 | Grant | Trans-NIH Recovery Act Research Support: HIPPOCAMPAL PLASTICITY IN CO-MORBID DIABETES AND DEPRESSION There is a growing appreciation that the complications of diabetes extend to the central nervous system (CNS), including structural and functional deficits in the hippocampus. Deficits in hippoca | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| BARNES-JEWISH HOSPITAL | $290,106 | Grant | Trans-NIH Recovery Act Research Support: NAME: Timely End-of-Life Communication to Parents of Children with Brain Tumors. DESCRIPTION: Having a child diagnosed with a cancer that has a poor prognosis is a highly stressful situation and one in which parents need to make very difficult decisions | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| YALE UNIVERSITY | $1,345,812 | Grant | Trans-NIH Recovery Act Research Support: Obesity and obesity related medical conditions contribute to increased mortality among persons with schizophrenia and increased healthcare costs. There are no treatments that have been convincingly shown to be effective for weight reduction in this popula | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| UNIVERSITY OF NEBRASKA | $371,250 | Grant | Trans-NIH Recovery Act Research Support: Anti-retroviral therapy (ART) for human immunodeficiency virus (HIV)-1 infection has prolonged and improved quality and longevity of life. Nonetheless, disease morbidities associated with HIV abound, including cognitive dysfunction (HIV associated dementi | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| UNIVERSITY OF ARKANSAS SYSTEM | $708,282 | Grant | Trans-NIH Recovery Act Research Support: Canonical Transient Receptor Potential Channels and Excitotoxicity Description: The neuronal cell death caused by over exposure to a neurotransmitter called glutamate is a shared event in several neurological diseases, such as epilepsy, stroke and head tr | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $1,121,657 | Grant | Trans-NIH Recovery Act Research Support: Vascular cognitive impairment is highly prevalent, yet its biological basis has not been well studied. The goal of this proposal is to elucidate the molecular and cellular pathological processes underlying retinal vasculopathy with cerebral leukodystrophy | Health and Human Services, Department of / National Institutes of Health | 9/08/2009 |
| UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC. | $140,076 | Grant | Trans-NIH Recovery Act Research Support: Chlamydiae infections have an immense impact of public health causing sterility, blindness, pneumonia, and correlated with formation of atherosclerotic lesions and heart disease. These obligate intracellular bacteria are perpetuated through a developmenta | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| YALE UNIVERSITY | $165,500 | Grant | Trans-NIH Recovery Act Research Support: This research investigates the role of young children's attitudes toward privilege in the development and maintenance of social group attitudes including social class and racial attitudes. There is now considerable evidence that experienced and perceived | Health and Human Services, Department of / National Institutes of Health | 9/10/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $148,000 | Grant | Trans-NIH Recovery Act Research Support: The objective of our project is to study the effect of mild (30%) maternal nutrient restriction on fetal adipogenesis in different fat depots [omental (intra-abdominal), subcutaneous abdominal (subcutaneous upper-body) and femoral (subcutaneous lower-body | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| UNIVERSITY OF NEBRASKA | $74,250 | Grant | Trans-NIH Recovery Act Research Support: An important component of treatment development for destructive behavior involves the identification of effective reinforcers. Functional analysis is one method of identifying the reinforcer that maintains destructive behavior. Identifying the specific re | Health and Human Services, Department of / National Institutes of Health | 5/13/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $146,458 | Grant | Trans-NIH Recovery Act Research Support: Currently 5FU/LV/oxaliplatin (FOLFOX) is the most commonly used therapeutic agent for colorectal cancer (CRC) treatment (Rx). The anti-tumor activity of FOLFOX depends on its ability to induce apoptosis by damaging the DNA and by altering the expression o | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF MASSACHUSETTS | $437,331 | Grant | Trans-NIH Recovery Act Research Support: Memory is probably one of the most widely studied neuronal phenomena since it is required for all living organisms to function efficiently in known and unknown environments. It has recently been proposed that impairment of memory formation in human beings | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $415,288 | Grant | Trans-NIH Recovery Act Research Support: Alcohol intoxication is the greatest contributing factor to transportation fatalities in the United States. Alcohol's (EtOH) major pharmacological target is GABAA receptors (GABAAR). The goal of our research is to develop novel anti-alcohol drugs, which m | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $466,021 | Grant | Trans-NIH Recovery Act Research Support: Generation of FAH-HCV constructs and synthesis of FAH-HCV libraries (Aims 1 and 2) We performed quality control of our mutagenized libraries based on the shuttle vectors pRS-FAH:Con1 and pRS-FAH:HCV-J6/JFH1 to confirm that our clones have on average 2-3 m | Health and Human Services, Department of / National Institutes of Health | 5/04/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $403,360 | Grant | Trans-NIH Recovery Act Research Support: Title: High throughput screens for modulations of inflammatory cytokine gene expression. Abstract: Inflammation can be beneficial for a normal immune response to microbial pathogens. However, prolonged inflammation can promote tissue damage during infec | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| MEDICAL COLLEGE OF WISCONSIN, INC., THE | $57,058 | Grant | Trans-NIH Recovery Act Research Support: Cellular restriction of HIV infection in host cells reflects innate antiviral immunity. Monocytes are important immune sentinels and precursors of antigen presenting cells. Undifferentiated human monocytes are resistant to HIV infection despite the expres | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $94,810 | Grant | Trans-NIH Recovery Act Research Support: TRIM5alpha(Tripartite motif-containing protein 5)proteins bind retroviral capsids after cell entry and restrict retroviral infection by blocking reverse transcription and/or integration of the viral genetic material {Nisole, 2005 #305; Towers, 2007 #310}. | Health and Human Services, Department of / National Institutes of Health | 7/23/2009 |
| YALE UNIVERSITY | $455,125 | Grant | Trans-NIH Recovery Act Research Support: Age-related macular degeneration is the predominant cause of vision loss in adults over 65. Lack of effective treatment stems from both the complexity of the disease, and lack of good animal models in which to study it. This proposal offers the potential | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| YALE UNIVERSITY | $163,896 | Grant | Trans-NIH Recovery Act Research Support: The neurotransmitter serotonin plays an important role in the development of depression. Serotonin is one of the brain's natural chemicals. Serotonin binds to serotonin receptors (binding sites) type 1B on brain cells to regulate emotion, anxiety, sleep, | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| APHIOS CORPORATION | $920,464 | Grant | Trans-NIH Recovery Act Research Support: This project entitled ?CFI Pathogen Inactivation Technology,? is in response to the challenge of developing Enabling Technologies to ?Ensure a safe and adequate blood supply through the development of new processing technologies.? There are a number of em | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF NEBRASKA | $499,999 | Grant | Trans-NIH Recovery Act Research Support: The goal of this proposal is to examine how impairments and alterations in trafficking and targeting of lipid droplets (LD) to specific organelles influences LD accumulation in steatosis and contributes to alcohol-induced fatty liver disease (AFLD). We h | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $909,998 | Grant | Trans-NIH Recovery Act Research Support: We seek to build a molecular classifier based on genetic, genomic, and imaging data from patients with neurodegenerative dementia. Genetic data will consist of SNP data collected across the genome; genomic data will consist of gene expression data in per | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $960,432 | Grant | Trans-NIH Recovery Act Research Support: We will use state-of-the-art metagenomic approaches to study the microbiome of the widespread human disease, chronic periodontitis. There is almost no information about the microbial community of this disease at the metagenomic level. The Human Microbiome | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| YALE UNIVERSITY | $991,054 | Grant | Trans-NIH Recovery Act Research Support: It is known that, in addition to genetic susceptibility in many diseases, environmental factors play a critical role in determining whether susceptible individuals develop the disease. However, it is not clear what these environmental factors are. The env | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| JOSLIN DIABETES CENTER, INC. | $999,868 | Grant | Trans-NIH Recovery Act Research Support: Imaging Strategies to Measure Brown Fat and it's Activity - Obesity results from an imbalance between energy intake and energy expenditure. In obesity these excess calories are stored in white adipose tissue (WAT) depots that are distributed throughout th | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $996,090 | Grant | Trans-NIH Recovery Act Research Support: Abdominal Colpopexy: Comparison of Endoscopic Surgical Strategies Objectives: The objective of this study is to compare costs and short-term outcomes of laparoscopic and robotic- assisted abdominal sacrocolpopexy (ASC) with respect to patient convalesce | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | $999,141 | Grant | Trans-NIH Recovery Act Research Support: For two years, four investigators will each hire a new full-time employee to identify and validate a novel therapeutic strategy for a group of rare inherited metabolic disorders, the Congenital Disorders of Glycosylation-Type I (CDG-I). These disorders re | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| YALE UNIVERSITY | $993,553 | Grant | Trans-NIH Recovery Act Research Support: Performance Indices of Social Disability in Toddlers with Autism' - addresses Challenge Area '(04) Clinical Research' and Specific Challenge Topic 'Autism: Addressing the Challenge (04-MH-101*)'; and Challenge Area '(01) Behavior, Behavioral Change, and P | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $999,213 | Grant | Trans-NIH Recovery Act Research Support: Dysfunction of GABAergic interneurons of the cerebral cortex has been implicated in a variety of major neuropsychiatric illnesses, including schizophrenia, autism, anxiety, and epilepsy (where depression is a major source of suffering). However, both our | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| NEWTON PHOTONICS INC | $1,004,618 | Grant | Trans-NIH Recovery Act Research Support: The sensor will be used in diagnostic laboratories and public health facilities. It will mitigate the effect of a biological attack by providing early detection and verification of intoxication by botulinum and many othe biological agents. | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| TRUDEAU INSTITUTE, INC. | $97,684 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to understand how latent viral infection drives changes in the antiviral CD8 T cell repertoire over time, using murine gammaherpesvirus-68 (?HV68) as a model of latent herpesvirus infections. | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| MOUNT DESERT ISLAND BIOLOGICAL LABORATORY (INC) | $3,863,077 | Grant | National Center for Research Resources, Recovery Act Construction Support: The Mount Desert Island Biological Laboratory, a non-profit biomedical research institution with an expanding year-round research program, seeks support for construction of a 13,267 sq. ft. laboratory building to promote collalaborative multidisciplinary re... Show more | Health and Human Services, Department of / National Institutes of Health | 8/24/2009 |
| MARSHALL UNIVERSITY RESEARCH CORPORATION | $70,822 | Grant | Trans-NIH Recovery Act Research Support: The goal of this mechanistic-based study is to identify specific cellular macromolecules involved in methamphetamine (MA)/dopamine (DA) induced neurotoxicity which could potentially serve as targets for pharmacological intervention aimed at attenuating MA | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF ILLINOIS | $82,556 | Grant | Trans-NIH Recovery Act Research Support: This fellowship will support the study of the metabolic control of hepatitis B virus (HBV) biosynthesis and more specifically bile acid regulation of HBV both in cell culture and in vivo. The long-term objectives are to understand the in vivo mechanisms r | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| MONTANA STATE UNIVERSITY, INC | $57,756 | Grant | Trans-NIH Recovery Act Research Support: The goal for this project is to address the current lack of knowledge regarding the host innate immune response to C. Burnetii infection. Specifically, we plan to determine the contribution of various alveolar macrophage subsets to both the initiation and | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $82,556 | Grant | Trans-NIH Recovery Act Research Support: Chronic hepatitis C virus (HCV) infection afflicts about 3 million people in the United States and is the leading indication for liver transplantation (CDC, NHANES III). Currently treatments are effective in only about 50% of patients. Improved treatments | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF MARYLAND BALTIMORE COUNTY | $62,781 | Grant | Trans-NIH Recovery Act Research Support: This project will qualitatively examine the experience, meaning and interpretation of BZD dependence in a sample of community dwelling women age 75 or older. It will also determine whether culture has a role in the experience of BZD dependence among wome | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $102,208 | Grant | Trans-NIH Recovery Act Research Support: This grant provides postdoctoral level funding for studies on the mechanism innate immunity to African trypanosomes. Humans exhibit an innate immunity to the mammalian parasite Trypanosoma brucei brucei. Immunity to T. b. brucei is provided by a subclass | Health and Human Services, Department of / National Institutes of Health | 7/23/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $51,710 | Grant | Trans-NIH Recovery Act Research Support: Under normal conditions, most T lymphocytes are made in the thymus. However, the thymus degenerates with age, beginning around puberty. Because output of new Tcells from the thymus is proportional to its mass, age-related thymic atrophy results in a prog | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| TRUSTEES OF PRINCETON UNIVERSITY, THE | $109,144 | Grant | Trans-NIH Recovery Act Research Support: Aging is associated with a decline in cognitive function that begins in midlife. Age-associated deficits in learning and memory are often accompanied by impaired synaptic and structural plasticity in the hippocampus, including diminished adult neurogenesi | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $97,684 | Grant | Trans-NIH Recovery Act Research Support: The 1918-19 influenza virus claimed the lives of more than 20 million people worldwide and the determinants of its extreme virulence are currently under investigation. Influenza A virus harbors a segmented, negative-sense RNA genome contained within an en | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF WASHINGTON | $101,254 | Grant | Trans-NIH Recovery Act Research Support: Project Summary: West Nile Virus (WNV) is an NAID Category B infectious agent and since its introduction into the United States in 1999, has become the leading cause of arboviral encephalitis in the United States. In recent WNV outbreaks, healthy young | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $105,520 | Grant | Trans-NIH Recovery Act Research Support: Bacterial cell cycle progression and development rely on a backbone of transcription factors and phosphorelay systems to temporally coordinate gene expression with events in the cell. The phosphorelays have been relatively well characterized in the model | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $97,684 | Grant | Trans-NIH Recovery Act Research Support: Title: T cell Survival and Metabolic Fitness in Inflammation and Infection Purpose:Postdoctoral Fellowship. This funding mechanism is to (1) support the training of scientists at the postdoctoral level, and (2) to advance scientific knowledge of the pr | Health and Human Services, Department of / National Institutes of Health | 6/17/2009 |
| LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY | $97,684 | Grant | Trans-NIH Recovery Act Research Support: Genetic analysis of the NKT cell response to Streptococcus pneumoniae: Invariant (I) natural killer (NK)T cells are a unique T lymphocyte subset that expresses an invariant T cell antigen receptor (TCR) alpha chain that is conserved between mice and huma | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF CONNECTICUT | $97,092 | Grant | Trans-NIH Recovery Act Research Support: The induction of peripheral tolerance is critical for deterrence of autoimmunity. Most self-reactive T cells are deleted during development in the thymus. However, this additional process is not absolute and occasionally some self-reactive T cells can e | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| MEHARRY MEDICAL COLLEGE | $499,688 | Grant | Trans-NIH Recovery Act Research Support: Provide Meharry Medical College researchers with a modern vertebrate animal facility for research on cancer, women's health, brain and behavior disorders, cardiovascular diseaes, HIV AIDS research and environmental diseases. | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| DREXEL UNIVERSITY | $500,000 | Grant | Trans-NIH Recovery Act Research Support: The objective of this project is to enhance current and future research productivity and to remain in compliance with Federal regulations for the care and use of research animals at the Center City campus of Drexel University College of Medicine. The New | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF ROCHESTER | $151,463 | Grant | Trans-NIH Recovery Act Research Support: This award is for equipment only. The University of Rochester Medical Center (URMC) is sponsoring the construction of a new enhanced Animal Biosafety Level 3 (eABSL3) facility in shell space of the URMC MRBX basement. The facility is being designed to sa | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $499,105 | Grant | Trans-NIH Recovery Act Research Support: Vital biomedical research and integrity of scientific data depend on excellent animal care. The University of Alabama at Birmingham (UAB) Animal Care and Use Program is committed to the long-term goals of providing and maintaining consistently high qualit | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| UNIVERSITY OF KENTUCKY | $1,170,973 | Grant | Trans-NIH Recovery Act Research Support: Prescription opioid misuse and abuse are increasing problems in the United States. In the 2006 National Survey on Drug Use and Health, 5.2 million Americans had illicitly used a prescription opioid in the past month. National rates of illicit prescription | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF WASHINGTON | $1,415,659 | Grant | Trans-NIH Recovery Act Research Support: The broad, long-term objective of the proposed randomized clinical trial is to evaluate the efficacy and mechanisms of change of two cognitive-behavioral aftercare treatments for alcohol and other drug (AOD) use disorders in preventing AOD relapse compare | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| WISTAR INSTITUTE OF ANATOMY & BIOLOGY | $5,581,859 | Grant | Trans-NIH Recovery Act Research Support: It is the primary objective of this program to elucidate correlates of immune-mediated protection against HIV-1 infection using pre-clinical animal models. To this end, Project 1 will determine humoral and cell-mediated immune responses to an attenuated S | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| PACIFIC INSTITUTE FOR RESEARCH AND EVALUATION | $999,938 | Grant | Trans-NIH Recovery Act Research Support: The revised principal aim of this P20 is to form an Impaired-Driving Center (IDC), to build institutional capacity to create a laboratory for the investigation of the individual and epidemiological risk and protective factors for impaired driving with an | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $1,691,346 | Grant | Trans-NIH Recovery Act Research Support: This three-year funding proposal for a P20 Center provides a new paradigm for medication development for the treatment of alcoholism by bringing experienced alcohol researchers together with experts in chemistry, proteomics, gene delivery and Drosophila g | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $1,150,229 | Grant | Trans-NIH Recovery Act Research Support: This application, responding to RFA-OD-09-005 Recovery Act Limited Competition: Core Centers for Enhancing Research Capacity in U.S. Academic Institutions, proposes to recruit and support two new Assistant Professor Faculty to the Massachusetts Alzheimer | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $1,308,693 | Grant | Trans-NIH Recovery Act Research Support: Significance We propose to recruit a bright and productive young clinical investigator from the University of Rochester to a tenure-track Assistant Professorship and mentor her development as a researcher in mind/body medical interventions. Her work will | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $1,149,999 | Grant | Trans-NIH Recovery Act Research Support: Acupuncture, a component of traditional Chinese medicine, has been used for thousands of years to treat a multitude of ailments. Recent scientific evaluation has suggested that this therapy may demonstrate clinical benefit for a number of conditions inclu | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $520,000 | Grant | Trans-NIH Recovery Act Research Support: The Center for Nanoscale Materials and Biointegration (CNMB) was formally approved by the University of Alabama Board of Trustees in February 2006 as an interdisciplinary research and student-training center focusing (i) on the synthesis and characterizat | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF NEW MEXICO | $676,087 | Grant | Trans-NIH Recovery Act Research Support: The Department of Pathology at the University of New Mexico proposes a NIGMS Biomedical Research Core Center (BRCC) in Immunology and Imaging that will recruit and mentor two outstanding PhD, MD or MD/PhD tenure track research faculty at the Assistant Pro | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $752,314 | Grant | Trans-NIH Recovery Act Research Support: The intracellular movement of molecules is a fundamental property of living cells, being reflected in a very large number of cellular processes, including cell division, transport within nerve axons and endocytosis of nutrients and signaling molecules, to | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CHICAGO, THE | $736,880 | Grant | Trans-NIH Recovery Act Research Support: The department of Molecular Genetics and Cell Biology is applying to the NIGMS for a Recovery Act grant (RFA-OD-09-005) to recruit a tenure track Assistant Professor in the area of Biochemistry of Chromatin Structure and Function. The department had deter | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $814,150 | Grant | Trans-NIH Recovery Act Research Support: The innate immune system is an evolutionarily ancient and highly conserved first line of host defense against pathogens in plants, fungi, insects and mammals. Innate immunity is essential for early responses to infection and effective immune responses, bu | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $733,088 | Grant | Trans-NIH Recovery Act Research Support: This NHLBI PSO application requests funding for two years salary plus appropriate start up funds for a newly independent investigator whose research will complement the research underway in the Brigham & Women's Hospital's (BWH) Division of Sleep Medicine | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $1,119,435 | Grant | Trans-NIH Recovery Act Research Support: The overall purpose of this P30 award was to recruit an outstanding new physician scientist faculty member and foster the development of this individual in the University of Minnesota Pulmonary, Allergy, Critical Care, and Sleep (PACCS) Division. This fac | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF PUERTO RICO-MEDICAL SCIENCES CAMPUS | $1,395,000 | Grant | Trans-NIH Recovery Act Research Support: New Recruitment to Expand Neuroscience Research at the UPR School of Medicine: The purpose of this application is to request funds to support the hiring of two new faculty at the Department of Anatomy & Neurobiology (A & N) of the University of Puerto Ric | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF CONNECTICUT | $1,335,239 | Grant | Trans-NIH Recovery Act Research Support: The Department of Physiology and Neurobiology (PNB) at the University of Connecticut has a long history of high research productivity. The objective of this proposal is to recruit a new tenure-track assistant professor to a position that was previously fr | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| EMORY UNIVERSITY | $1,385,000 | Grant | Trans-NIH Recovery Act Research Support: Faculty Recruitment in Novel Therapeutic Strategies for Neurodegenerative Disease. This proposal seeks support for new faculty recruitment to enhance research capacity at Emory University in the area of novel therapeutic strategies for neurodegenerative d | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $1,263,092 | Grant | Trans-NIH Recovery Act Research Support: The Jungers Center for Neurosciences Research proposes to recruit a newly-independent neuroscientist to expand and enhance its research efforts around the theme of Axonal Degeneration and Regeneration. Founded in 2006, the Jungers Center is a new and evol | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| PURDUE UNIVERSITY | $1,049,455 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION: This proposal is directed to solving the problem of the slow rate of generation of high resolution structures of integral membrane proteins that can be useful as drug targets and in medicine. The group combines established expertise in membra | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | $723,722 | Grant | Trans-NIH Recovery Act Research Support: The present application takes advantage of the high quality data that already exist and proposes a study that can be completed within 2 years (at a cost of $737,367). It will combine data from the youngest PYS cohort from ages 7 through 25 with data from | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $484,358 | Grant | Trans-NIH Recovery Act Research Support: This application is focused on the design, synthesis and evaluation of potential biological probes and treatment agents for alcohol dependence based on their actions on the nociceptin (NOP) receptor. We seek to identify compounds thai act as partial agoni | Health and Human Services, Department of / National Institutes of Health | 5/22/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $1,265,834 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this project is to evaluate the effects of binge-type alcohol exposure on oocyte quality. There are no studies known to us that have examined the effects of binge alcohol consumption on fertility in women or any animal model, yet binge | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF WASHINGTON | $2,526,921 | Grant | Trans-NIH Recovery Act Research Support: Age-related cognitive decline (ARCD) exists in a continuum with more severe cognitive dysfunction that that often is a demeinta prodrome and can be operationally defined as Mild Cognitive Impairment (MCI), and ultimately with dementia. ARCD is a major so | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $683,736 | Grant | Trans-NIH Recovery Act Research Support: This project will use fMRI to study the cognitive and brain mechanisms of risk avoidance. Impairments in these mechanisms are associated with substance use and abuse. Knowledge of such mechanisms can inform the prevention and treatment of substance abuse | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO | $718,083 | Grant | Trans-NIH Recovery Act Research Support: This R01, submitted in response to RFA-DA-09-001 (Medications Development for Cannabis-Related Disorders), has been modified to accommodate a 2-year budget. The grant proposes using pre-clinical measures of cannabinoid withdrawal in non-human primates to | Health and Human Services, Department of / National Institutes of Health | 6/19/2009 |
| YALE UNIVERSITY | $438,880 | Grant | Trans-NIH Recovery Act Research Support: Sleep is an essential biological function that has physiological, behavioral and temporal characteristics. It is regulated by homeostatic and circadian processes. The knowledge of the importance of sleep and the adverse effects of sleep deprivation has gr | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $423,500 | Grant | Trans-NIH Recovery Act Research Support: Obstructive sleep apnea (OSA) afflicts 20 million adults in the United States, and is associated with increased morbidity and mortality. Major male-female differences in the incidence and co-morbidites of the disorder are poorly understood. Since brain ch | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| YALE UNIVERSITY | $455,125 | Grant | Trans-NIH Recovery Act Research Support: Pain caused by activation of pain-sensing peripheral neurons (nociceptors) is a major source of human suffering and economic loss. Pain sensation requires the coordinated participation of a variety of ion channels. Our long-term goal is the development of | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $3,855,398 | Grant | Trans-NIH Recovery Act Research Support: COMPARATIVE EFFECTIVENESS AND OUTCOMES IMPROVEMENT (CEOI) CENTER Despite numerous initiatives over the past three decades to improve healthcare quality and outcomes in the United States, progress remains slow; this is particularly true for chronic diseas | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $706,500 | Grant | Trans-NIH Recovery Act Research Support: Numerous studies have shown that the protein tyrosine phosphatase SHP-1 modulates the expression of proinflammatory genes in leukocytes and glia that have been shown to cause inflammatory demyelination in the CNS. Accordingly, genetic deficiency in SHP-1 | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $737,350 | Grant | Trans-NIH Recovery Act Research Support: Molecular Genetics of Midline Glial Development Glia perform a variety of important roles in controlling and supporting neurotransmission in the nervous system. The Drosophila midline glia play a unique role in CNS development by controlling the guidance | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | $1,034,186 | Grant | Trans-NIH Recovery Act Research Support: Neural stem cells (NSCs) can be propagated in vitro for extensive periods of time while retaining the ability todifferentiate into neurons, astrocytes and oligodendrocytes. However, NSCs are limited in their potential toyield specific neuron types. Nave N | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $168,805 | Grant | Trans-NIH Recovery Act Research Support: This is a 2-year grant application in response to PA-06-391: Research on Autism and Autism Spectrum Disorders R03. Clinical, animal, and genetic evidence points to a role for the hormone oxytocin in autism and suggests that oxytocin related abnormalities | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| EAST TENNESSEE STATE UNIVERSITY | $208,025 | Grant | Trans-NIH Recovery Act Research Support: The treatment of infectious diseases caused by antibiotic resistant microorganisms requires a better understanding of how antibiotics kill susceptible cells and how resistance develops. The structural features of antimicrobial agents and their interaction | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| UNIVERSITY OF TENNESSEE | $200,391 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this proposal is to gain a better understanding of the developmental processes involved in muscle development, while providing a dynamic learning environment for undergraduate students. In this proposal, we plan to identify and charact | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $378,750 | Grant | Trans-NIH Recovery Act Research Support: The body's defense system can be divided into two components, the innate and adaptive immune systems. The innate immune system acts as the first line of defense against invading pathogens (e.g., bacteria) and is found in plants and all animals. The respon | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| TRANSLATIONAL GENOMICS RESEARCH INSTITITUE, THE | $473,517 | Grant | Trans-NIH Recovery Act Research Support: This project is designed to develop and validate novel direct detection real-time PCR assays for the caustive agenst of Valley Fever Coccidiodes posadassi and C.immitis. Valley Fever, a fungal disease, is one of the most common respiratory infectious dis | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $418,502 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Abstract: Facultative intracellular Brucella species cause brucellosis in animals and humans and have been classified as NIAID category B priority pathogens. Brucella infects the body via the respiratory tract, the ski | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $994,872 | Grant | Trans-NIH Recovery Act Research Support: 'Chemosensing in the Gastrointestinal Tract'. Sensing of luminal contents by the gastrointestinal (GI) mucosa plays a critical role in the regulation of digestive functions and protection from harmful substances. The recent discovery that bitter taste re | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| YALE UNIVERSITY | $901,569 | Grant | Trans-NIH Recovery Act Research Support: Spatial mapping of human and animal brain function is crucial for the diagnosis of brain disorders, to follow the efficacy of therapy or intervention and to increase scientific knowledge. 17O NMR based mapping can become a fast and robust tool to assess a | Health and Human Services, Department of / National Institutes of Health | 4/30/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $1,449,988 | Grant | Trans-NIH Recovery Act Research Support: Apathy in Alzheimer's dementia (AD) is a significant public health problem with serious adverse consequences for patients and caregivers. Apathy affects approximately 70% of AD patients, making it one of the most common neuropsychiatric symptoms (M. S. Me | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $766,000 | Grant | Trans-NIH Recovery Act Research Support: Chemotaxis allows polymorphonuclear neutrophils (PMN) to rapidly reach infected sites and inflamed host tissues. Inflammation results in damage of host tissues by excessively activated PMN. Better knowledge of how PMN chemotaxis is controlled may lead to | Health and Human Services, Department of / National Institutes of Health | 5/12/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $775,500 | Grant | Trans-NIH Recovery Act Research Support: Epstein-Barr virus (EBV) is an extremely successful pathogen, able to persist lifelong as a latent infection within B lymphocytes with little overt disease. However, a breakdown in immune surveillance, e.g., as a consequence of AIDS, remains a significant | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF IOWA, THE | $764,300 | Grant | Trans-NIH Recovery Act Research Support: S. enterica serovar Typhimurium is an important human pathogen causing acute gastroenteritis following ingestion of contaminated food. One of the major vehicles of infection for humans is contaminated poultry because the bacteria easily infect these anima | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $1,136,844 | Grant | Trans-NIH Recovery Act Research Support: Malaria is a major cause of global morbidity and mortality, with its greatest impact on African children who account for most of the 1 to 2.7 million annual deaths (WHO, 2000). P falciparum, the major causative agent of human malaria, has remained a major | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $804,640 | Grant | Trans-NIH Recovery Act Research Support: Mosquitoes utilize a variety of strategies to combat pathogens, including viruses. The long term_ goal of the PIs research is to elucidate, at the molecular level, the immune responses of the mosquito vector Aedes aegypti to infection with a range of vira | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $1,150,015 | Grant | Trans-NIH Recovery Act Research Support: Malaria kills over one million people each year. Most malaria deaths occur in Africa and most of the victims are children under five. An effective, affordable vaccine would greatly reduce the morbidity, mortality, and economic burden imposed by malaria. W | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF FLORIDA | $732,500 | Grant | Trans-NIH Recovery Act Research Support: Tuberculosis is endemic among patients with AIDS and follows an aggressive course with poor localization of mycobacteria into granuloma and widespread infection. Granulomas are monocyte rich collections of cells which derive from the circulating periphera | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF CHICAGO, THE | $780,000 | Grant | Trans-NIH Recovery Act Research Support: Evidence suggests that one mechanism of peripheral immunologic tolerance occurs through the process of T cell anergy. Anergic T cells have been characterized to have a defect in TCR/CD28-mediated Ras activation. Recent data have indicated that upregulated | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $593,593 | Grant | Trans-NIH Recovery Act Research Support: The prevalence of cancer in the United States is associated with costs greater than $100 billion annually, and the causes of this disease are not entirely understood. It remains possible that exposure to chemical carcinogens contributes significantly to b | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $639,100 | Grant | Trans-NIH Recovery Act Research Support: The lack of efficient gene delivery systems is the most important barrier to the use of gene therapy for cancer. There is an urgent need to develop vectors that are capable of selective, efficient, and safe delivery of genes to tumors. Until this need is | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $610,370 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The proposed research will use hierarchical Bayesian modeling to tackle three interrelated problems in the analysis of population-based survey data: accounting for unequal probabilities of inclusion due to sample desig | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| DUKE UNIVERSITY | $517,920 | Grant | Trans-NIH Recovery Act Research Support: RNA aptamers have been generated against a variety of proteins including a few cell surface receptors. In general such aptamer act as potent inhibitors of their target proteins both in vitro and in vivo. Moreover, a few of these antagonistic aptamers have | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $1,164,381 | Grant | Trans-NIH Recovery Act Research Support: It is the over 3,800 chemical components of tobacco smoke, which makes it the leading cause of death in America. Associated with cardiovascular disease, chronic obstructive pulmonary disease, and pancreatic disease, tobacco smoke is responsible for more d | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| NEW YORK MEDICAL COLLEGE | $659,850 | Grant | Trans-NIH Recovery Act Research Support: Two hundred million people world wide are affected by thyroid proliferative diseases (TPD), which include goiter, cancer and adenoma. Women are three times more susceptible than men and overall the incidence of thyroid dysfunction occurring in one in eigh | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $683,022 | Grant | Trans-NIH Recovery Act Research Support: PTEN Deficiency and Tumor Development PTEN is one of the most frequently mutated genes in human cancer. We have previously demonstrated that PTEN plays an essential role in the maintenance of genomic stability and that PTEN controls genome integrity throu | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| JOHN B. PIERCE LABORATORY, INC., THE | $1,189,290 | Grant | Trans-NIH Recovery Act Research Support: 'High-speed, wide field fluorescent imaging of cortex in freely moving animals This project will produce a miniature microscope/imaging system which can be head mounted and will allow the recording of optical signals of changes in membrane voltage and ca | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $1,184,101 | Grant | Trans-NIH Recovery Act Research Support: This project will improve scientists ability to use medical imaging to quantitatively assess the effects of healthydevelopment, aging and disease on the connectivity between different regions of the human brain. Scientificinterest in brain connectivity h | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF UTAH, THE | $737,049 | Grant | Trans-NIH Recovery Act Research Support: Adrenoleukodystrophy (ALD) is a rare and oftentimes fatal progressive neurodegenerative disease. The most common form of the disease is X-linked (X-ALD); it occurs equally in all ethnic groups with an estimated incidence of 1:17,000. X-ALD is a clinically | Health and Human Services, Department of / National Institutes of Health | 7/19/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $194,500 | Grant | Trans-NIH Recovery Act Research Support: These studies are designed to explore the feasibility of designing new opioid analgesics that we predict will produce less analgesic tolerance and limited side effects such as constipation and respiratory suppression. The experiments will be based on eluc | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $463,500 | Grant | Trans-NIH Recovery Act Research Support: This application responds to RFA-DA-09-016, Behavioral Pharmacology and Genetics: Translating and Targeting Individual Differences, and describes studies that will determine the genetic basis for individual differences in the effects of amphetamine (AMPH) | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF TEXAS AT DALLAS | $150,000 | Grant | Trans-NIH Recovery Act Research Support: Cochlear implant technology has developed consistently and rapidly, since auditory prostheses first came into widespread use about twenty years ago. Nowadays, cochlear implant devices can guarantee that even profoundly deaf people can enjoy hearing sensat | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF KENTUCKY | $222,750 | Grant | Trans-NIH Recovery Act Research Support: There is accumulating evidence for an increasing incidence of chronic diseases in the human population. These diseases are generally complex, with aspects of genetic control interacting with environmental stressors to trigger the symptoms of the diseases. | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $145,418 | Grant | Trans-NIH Recovery Act Research Support: Adolescents who are maltreated are at elevated risk for developing internalizing problems and externalizing problems. However, not all maltreated adolescents are equally vulnerable to developing mental health problems. Understanding factors that different | Health and Human Services, Department of / National Institutes of Health | 4/29/2009 |
| LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER | $137,950 | Grant | Trans-NIH Recovery Act Research Support: Intrauterine growth restricted newborns have an increased risk of adult obesity, hypertension and coronary heart disease. Obesity alone accounts for 65-78% of essential hypertension. Although the mechanisms underlying these associations are not fully unde | Health and Human Services, Department of / National Institutes of Health | 4/27/2009 |
| UNIVERSITY OF WASHINGTON | $1,287,488 | Grant | Trans-NIH Recovery Act Research Support: Immediate treatment of CIN 2,3 has been the standard of care, even though some such lesions likely would never progress to ICC and, in young women, some lesions spontaneously regress. However, because there is no way to predict the natural history of a CI | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $932,394 | Grant | Trans-NIH Recovery Act Research Support: There is mounting evidence that lymphatic angiogenesis plays an important role in tumor metastasis. While we know a little bit about the VEGF family members that stimulate lymphangiogensis, there is still much we don't know. This application proposes to s | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $1,687,835 | Grant | Trans-NIH Recovery Act Research Support: Childhood aggressivity at age 7 is associated with a fourfold increased risk for illicit drug dependence at age 25. Despite high rates of aggressivity in children with histories of parental neglect, theory-driven and efficacious drug prevention programs t | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UMDNJ-ROBERT WOOD JOHNSON MEDICAL SCHOOL | $780,000 | Grant | Trans-NIH Recovery Act Research Support: This R01 grant proposal describes a randomized, double-blind, placebo-controlled trial of nicotine nasal spray (NNS) as an aid for smoking cessation in 70 individuals with schizophrenia. The objectives of this study are to determine the efficacy of NNS w | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| TREATMENT RESEARCH INSTITUTE | $953,273 | Grant | Trans-NIH Recovery Act Research Support: According to national epidemiologic surveillance systems (i.e., Monitoring the Future, the National Survey on Drug Use and Health), adolescent nonmedical use of highly addictive prescription opioid analgesic drugs (e.g., Vicodin-?, Oxycontin-?) and tranqu | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| NATIONAL DEVELOPMENT AND RESEARCH INSTITUTES, INC. | $1,149,189 | Grant | Trans-NIH Recovery Act Research Support: Substance use among youth remains a major public health problem. About half of all 12th graders have tried an illicit drug and over 72% of this same age group have used alcohol. Rates of abuse of prescription opioids among youth are estimated to have incr | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $1,213,643 | Grant | Trans-NIH Recovery Act Research Support: As reported in each ARRA update:The Revised ARRA Aims include Aim 1 of the original application (to compare extinction of limbic activation by seen vs. unseen cocaine cues), and the Exploratory Aim (to examine DA modulating genetics).Aim 2 of the origina | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $1,226,258 | Grant | Trans-NIH Recovery Act Research Support: In vivo profiling of glial and neuronal activities in psychostimulant abuse (PI: Christina H Liu, PhD) Drug addiction is a chronic brain disorder that severely hampers productivity of many members of our society. One of the most used drugs of abuse is amp | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $1,067,183 | Grant | Trans-NIH Recovery Act Research Support: Methamphetamine (METH) use is of major public health concern given its prevalence among individuals who are HIV infected and its association with HIV transmission risk behaviors, particularly high-risk sexual behavior. METH use strongly alters brain dopa | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF MASSACHUSETTS | $746,038 | Grant | Trans-NIH Recovery Act Research Support: Obesity and health complications related to obesity, including diabetes, impact a significant proportion of the population in the United States, and projections indicate that the number of obese and overweight individuals will continue to rise in the futu | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $469,619 | Grant | Trans-NIH Recovery Act Research Support: 'Three-Dimensional Imaging of Whole Cells By Using X-Ray Diffraction Microscopy' X-ray protein crystallography is currently the primary methodology used for determining the 3D structure of protein molecules at near-atomic or atomic resolution. However, ma | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| IOWA STATE UNIVERSITY OF SCIENCE AND TECHNOLOGY | $616,295 | Grant | Trans-NIH Recovery Act Research Support: The M2 protein of influenza A virus forms a pH-gated proton channel that is important for viral infection and replication. The antiviral drug amantadine used to be effective in blocking this channel, until the recent emergence of a mutant, S31N, of the | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $153,090 | Grant | Trans-NIH Recovery Act Research Support: Cloning and Characterization of Zebrafish Endocrine Pancreas Genes Abstract: The long-term goal of this application is to develop strategies for cell based replacement therapy to treat diabetes by understanding the molecular mechanisms regulating cell s | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| YALE UNIVERSITY | $453,547 | Grant | Trans-NIH Recovery Act Research Support: Stress is a well known risk factor for relapse in alcohol-dependence. The goal of this project is to identify specific stress-related genes that may predict the risk for relapse in alcohol dependent subjects and allow individuals at higher-risk to be dire | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| UNIVERSITY OF TENNESSEE | $407,000 | Grant | Trans-NIH Recovery Act Research Support: The goal of this research proposal is to identify virulence factors in Francisella tularensis Schu S4. In nature, F. tularensis causes the zoonotic disease tularemia. F. tularensis is a category A select agent because of its highly infectious nature and t | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC. | $396,060 | Grant | Trans-NIH Recovery Act Research Support: Many Gram-negative pathogenic bacteria employ a complex protein secretion apparatus termed type III secretion system (T3SS) to transport bacterial effector proteins into eukaryotic host cytoplasm. The effector proteins delivered by T3SS are capable of mod | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF NEBRASKA | $412,854 | Grant | Trans-NIH Recovery Act Research Support: A recent report by Kohanski et al. demonstrated that multiple classes of bactericidal antibiotics stimulate the production of hydroxyl radicals thus accelerating bacterial cell death in Escherichia coli. Although different classes of antibiotics have uni | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| YALE UNIVERSITY | $433,362 | Grant | Trans-NIH Recovery Act Research Support: Memory CD8 T cells are a critical component of adaptive immunity that protect us against infectious disease and even cancer, however the mechanisms for how these cells develop during infection or vaccination are not clear. The ultimate goal of this propos | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| TRUDEAU INSTITUTE, INC. | $502,000 | Grant | Trans-NIH Recovery Act Research Support: The human ?-herpesviruses, Epstein-Barr virus (EBV) and Kaposi?s sarcoma-associated herpesvirus (KSHV), establish persistent infections that are maintained for the life of the host and are associated with the development of a variety of malignancies. The | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| YALE UNIVERSITY | $389,125 | Grant | Trans-NIH Recovery Act Research Support: Defining the neural pathways and circuits of the brain is critical for understanding neurological and psychiatric disease. The proposed experiments will characterize how brain reward circuits respond to changes in levels of a hormone that is produced in f | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| MONTANA STATE UNIVERSITY, INC | $391,875 | Grant | Trans-NIH Recovery Act Research Support: Personnel are in place and research is progressing to develop nanoplatforms for selectively killing a bacterium that resides in a biofilm consortium. The long term goal is to test the hypothesis that selective elimination of periodontal pathogens will all | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY OF MEMPHIS | $387,750 | Grant | Trans-NIH Recovery Act Research Support: The specific aims of this project are (1) To create a working partnership among interdisciplinary stakeholders (land developers, home builders, realtors, home buyers, policy makers, and public health professionals) aimed at deepening current understanding | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF TENNESSEE | $403,880 | Grant | Trans-NIH Recovery Act Research Support: Age-related macular degeneration (AMD) is characterized since its earliest stages by formation of deposits between the Bruch's membrane (BM) and the retinal pigment epithelium (RPE), termed drusen. In recent years, a role for inflammation in the pathogene | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $423,500 | Grant | Trans-NIH Recovery Act Research Support: CARDIOVASCULAR AND THERAPEUTIC POTENTIAL OF REPROGRAMMED HUMAN FIBROBLASTS Differentiation of the cells of the inner cell mass into the specialized cells required for forming the complex tissues that comprise living organisms has traditionally been view | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $419,213 | Grant | Trans-NIH Recovery Act Research Support: This R21 proposal entitled Language and Risk for Schizophrenia is for funding to determine whether structural and functional changes in the brain white matter pathways that connect frontal and temporal cortices are significantly different in people who ar | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $633,870 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (01) Behavior, Behavioral Change, and Prevention and specific Challenge Topic 01-OD (OBSSR)-101* Tools for studying cultural phenomena. Population dynamic models of culture conceptualize culture as informati | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $754,565 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (01) Behavior, Behavioral Change, and Prevention and specific Challenge Topic, 01-GM-104: Mechanisms of Behavior Change Research. Cognitive-behavioral therapy (CBT) is well-established as an effective treatm | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $3,840,375 | Grant | Trans-NIH Recovery Act Research Support: Of two vaccine candidates tested in rats at the Scripps-based Koob lab one was found to be superior and advanced to the rat self administration studies. This vaccine evoked anti-cocaine titers of about 106 and in a parallel study using locomotor behavior | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| YALE UNIVERSITY | $1,035,964 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to test risk and resiliency pathways linking social determinants of health and child characteristics to young children's health. We will examine the role of four social determinants of health (i.e., social position, racism, seg | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF MIAMI | $751,750 | Grant | Trans-NIH Recovery Act Research Support: Classical Pavlovian conditioning has a major role in the development and persistence of drug addiction. Consistent with this view, exposure of drug-abstained subjects to drug-associated cues precipitates relapse which is a major problem in the management | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $105,520 | Grant | Trans-NIH Recovery Act Research Support: Low dose oral tolerance is defined as the active suppression of a systemic immune response to a specific antigen by regulatory T cells (Tregs) generated in response to repeated ingestion of that antigen. Though ex- tensively studied, the specific mechanis | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $97,684 | Grant | Trans-NIH Recovery Act Research Support: Viral infection significantly impacts all forms of life. Since every virus and bacteriophage requires correct organization of its capsid proteins (CPs), the mechanisms by which these CPs assemble must ultimately be determined in order to devise efficaciou | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $51,710 | Grant | Trans-NIH Recovery Act Research Support: Coxsackievirus B (CVB) infection is the most common infectious cause of heart inflammation and can lead to chronic disease and cardiac failure. I have found that CVB3 induces minimal T cell responses in a murine model of infection and this may be associat | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| WASHINGTON UNIVERSITY, THE | $105,520 | Grant | Trans-NIH Recovery Act Research Support: Widespread resistance to long-used drugs and to newer quinoline-based drugs has prompted the need to better understand malaria parasite biology and pathogenesis. Egress from the infected RBCs by the invasive stage of the malaria parasite is a fundamental | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $84,650 | Grant | Trans-NIH Recovery Act Research Support: Methicillin-resistant Staphylococcus aureus (MRSA) infections pose a large threat to public health in the United States, causing nearly 19,000 deaths in 2005. Polymers attached to the surface of S. aureus (wall teichoic acids, WTAs) are required for these | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $763,667 | Grant | Trans-NIH Recovery Act Research Support: The aim of this ARRA proposal for NIDCD P30-supported new faculty recruitment at the University of Wisconsin (UW) - Madison is to foster the development of a leader in the field of voice and swallow neuroscience research. We will develop the career of an | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $1,343,850 | Grant | Trans-NIH Recovery Act Research Support: Although cochlear implants (CI) can dramatically improve speech recognition for many patients in quiet surroundings, CI performance and outcome is variable across individuals; speech recognition in noise is often worse, and music perception is not improve | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| MARINE BIOLOGICAL LABORATORY, THE | $802,500 | Grant | Trans-NIH Recovery Act Research Support: The Marine Biological Laboratory (MBL) in Woods Hole, Massachusetts, proposes to launch a high-impact, multidisciplinary and unique initiative in regenerative and stem cell biology drawing upon the special advantages of marine invertebrates. Regenerative | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| WASHINGTON UNIVERSITY, THE | $1,374,958 | Grant | Trans-NIH Recovery Act Research Support: This grant proposal is in response to RFA-OD-09-005, 'Recovery Act limited Competition: Supporting New Faculty Recruitment to Enhance Research Resources through Biomedical Research Core Centers' and is entitled 'Translational Neuroscientist and the Hope C | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| J.DAVID GLADSTONE INSTITUTES, THE | $955,000 | Grant | Trans-NIH Recovery Act Research Support: Transcription factors are key regulators of several aspects of organogenesis, and in the heart, several important DNA-binding transcription factors are powerful regulators of cardiac cell fate and organogenesis. Less well studied are the roles played by t | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| BROWN UNIVERSITY IN PROVIDENCE IN STATE OF RI AND PROVIDENCE PLANTATIONS | $1,144,012 | Grant | Trans-NIH Recovery Act Research Support: Significant effort has been committed to developing efficacious alcohol interventions for college students, while little attention has been paid to the needs of the majority of high school seniors who transition to work rather than a four-year college. Th | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| DE PAUL UNIVERSITY | $1,420,842 | Grant | Trans-NIH Recovery Act Research Support: The purpose of the study is to evaluate the effectiveness of the Oxford House model with Latino residents whose values, beliefs and behaviors differ depending on their level of acculturation. In the past, those Latino individuals who have used Oxford Hous | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| SYRACUSE UNIVERSITY | $1,085,149 | Grant | Trans-NIH Recovery Act Research Support: This project's long-term goal is to enhance the effectiveness of AUD relapse prevention interventions through advancing understanding of the relationships among interpersonal stress, affect regulation, alcohol lapse, and patterns of alcohol use following | Health and Human Services, Department of / National Institutes of Health | 9/08/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $755,912 | Grant | Trans-NIH Recovery Act Research Support: This project seeks to determine the mechanisms whereby ingestion of ethanol by dams increases the concentration of atRA (all-trans-retinoic acid) in vivo in embryo hippocampus during normal vitamin A (retinol) nutriture. We developed a LC/MS/MS assay with | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| UNIVERSITY OF IOWA, THE | $1,302,240 | Grant | Trans-NIH Recovery Act Research Support: Long-temn alcohol consumption progressively leads to multiple immune defects. Chronic alcoholics display lesions in both innate and adaptive immunity, and experience increased rates of bacterial and viral infection. Of particular interest, extended alcoho | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| UNIVERSITY OF CHICAGO, THE | $7,439,784 | Grant | Trans-NIH Recovery Act Research Support: Chronic obstructive pulmonary disease (COPD) is a key health condition. Comparative effectiveness research (CER) is underdeveloped, particularly in COPD. The development of a high impact CER research agenda requires a collaborative infrastructure between | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $1,273,134 | Grant | Trans-NIH Recovery Act Research Support: Heparin is a sulfated polysaccharide mixture that is widely used as baseline therapy in a number of clinical situations, especially for preventing thrombosis. While heparin has been administered in the clinic for the past several decades, recently, cluste | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $3,545,538 | Grant | Trans-NIH Recovery Act Research Support: Recent research on Very Low Birth Weight (VLBW) infants suggests that genetic factors account for 50 ? 80% of the variance in their susceptibility to bronchopulmonary dysplasia (BPD). Because California has for the past 3 decades stored Guthrie blood spo | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $3,470,154 | Grant | Trans-NIH Recovery Act Research Support: This project has the following specific aims: 1) Determine methods for shipping Notch-mediated expanded cord blood progenitor cells to outside centers for infusion, including preclinical evaluation of in vivo repopulating ability in our established murine | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF UTAH, THE | $2,802,895 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Our goal is to create a Master Person Index (MPI) that unambiguously identifies each individual who receives health care in the State of Utah. This index will enable qualified clinical and translational research to be | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $1,334,969 | Grant | Trans-NIH Recovery Act Research Support: Specific aims: 1) Establish a diverse coalition of policy makers, community members, and representatives and stakeholders from multiple systems and sectorseconomic development, business, education, labor, housing, transportation, environment, agriculture, | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| NORTHSHORE UNIVERSITY HEALTHSYSTEM RESEARCH INSTITUTE | $1,976,440 | Grant | Trans-NIH Recovery Act Research Support: This study aims to uncover informatin about differences in gene expression between individuals with schizophrenia versus controls, their relationship to previously studied genetic variation, and the joint analysis thereof. Besides informing important are | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| SALK INSTITUTE FOR BIOLOGICAL STUDIES,THE | $2,829,341 | Grant | Trans-NIH Recovery Act Research Support: The function of the nervous system is dependent on complex interactions between networks of neurons composed of multiple neuron types. Understanding how these networks function both in health and disease is dependent on understanding the precise connectiv | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF FLORIDA | $2,078,918 | Grant | Trans-NIH Recovery Act Research Support: In 2005, Science magazine identified understanding organ regeneration as one of the top 25 unanswered questions in science. For over 400 years scientists have been studying the amazing regenerative capacity of the Axolotl or Mexican Salamander. These amaz | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| YALE UNIVERSITY | $1,917,986 | Grant | Trans-NIH Recovery Act Research Support: This application, entitled 'The Role of Rare Variants in Multiple Sclerosis Risk', addresses Research and Research Infrastructure 'Grand Opportunities'. Many human autoimmune diseases, including multiple sclerosis (MS) are complex genetic disorders. MS is | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $690,666 | Grant | Trans-NIH Recovery Act Research Support: One of NIDA's highest priorities for funding is the development of effective pharmacotherapies for substance related disorders. In response to RFA-DA-09-005, soliciting pilot clinical/human studies of interventions that specifically target mechanisms kno | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| BAYLOR COLLEGE OF MEDICINE | $1,220,072 | Grant | Trans-NIH Recovery Act Research Support: The major goals of this project are to establish a method for optical analysis of neural circuits. Neuroplasticity is central to fundamental processes in the brain, including learning, recovery after brain injury, and neural circuit changes resulting from | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| HOUSE RESEARCH INSTITUTE | $1,568,212 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this award is to further our understanding of the genetic basis of Age Related Hearing Impairment (ARHI). Our current understanding of the genes that underlie this form of hearing loss is limited to a handful of candidate genes that fail t | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $1,464,850 | Grant | Trans-NIH Recovery Act Research Support: The broad, long-term objective of this study is to identify molecular targets regulating replacment tooth formation (RTF) in zebrafish that can be manipulated to treat tooth agenesis in humans. Zebrafish are the only currently available, tractable develo | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY OF IOWA, THE | $263,657 | Grant | Trans-NIH Recovery Act Research Support: The reduction in dental caries over the past 30+ years has been remarkable and started largely with the introduction of fluoride to the water supply. Increased access to dental care, improved oral hygiene, fluoride incorporation into professional dental p | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $777,139 | Grant | Trans-NIH Recovery Act Research Support: The spread or metastasis of tumor cells to the lymph nodes of patients with oral cancer is the leading cause of treatment failure and death in this disease. An accurate and reliable clinical test to detect lymph metastasis in oral cancer patients will be | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $863,693 | Grant | Trans-NIH Recovery Act Research Support: Tuberous sclerosis complex (TSC) is caused by germline inactivating mutations in the TSC1 or TSC2 genes, which encode hamartin (TSC1) and tuberin (TSC2), respectively. Both humans and mice with mutations in TSC1 or TSC2 can develop cystic kidney disease. | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF PITTSBURGH THE | $900,266 | Grant | Trans-NIH Recovery Act Research Support: The Hepatoprotective Role of the Orphan Nuclear Receptor LXR The liver X receptors (LXRs) are transcriptional factors highly expressed in the liver. The goal of this study is to determine whether LXRs play a hepatoprotective role in preventing toxicity f | Health and Human Services, Department of / National Institutes of Health | 8/25/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $632,809 | Grant | Trans-NIH Recovery Act Research Support: The Ras stimulated Raf MEK ERK kinase cascade is used over and over again to control many aspects of animal development, including tube formation. How this common signaling cascade elicits specific responses is still poorly understood. ERK is thought to p | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| THE VANDERBILT UNIVERSITY | $700,239 | Grant | Trans-NIH Recovery Act Research Support: While considerable progress has been achieved in understanding basic mechanisms of glomerular and renal fibrosis, the absence of a true experimental model for human FSGS has made it difficult to clearly understand how these basic mechanisms apply to huma | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| NORTHWESTERN UNIVERSITY | $762,433 | Grant | Trans-NIH Recovery Act Research Support: Non-alcoholic steatohepatitis (NASH) is one of the most common causes of liver disease in the United States, and accounts for the majority of cryptogenic cirrhosis. NASH is associated with the 'metabolic syndrome', which includes insulin-resistance, obesi | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| TEXAS A&M UNIVERSITY SYSTEM,THE | $628,182 | Grant | Trans-NIH Recovery Act Research Support: Human chronic cholestatic liver diseases (i.e., cholangiopathies) trigger the proliferation and damage of cholangiocytes that are the epithelial cells that line the biliary apparatus. These cholangiopathies cause morbidity and mortality and are a major re | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON | $699,950 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Over 400,000 Americans have end-stage renal disease (ESRD) requiring dialysis or kidney transplant for survival. ESRD in the US population doubled in the last decade and this increase is driven by diabetes and hyperten | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| BAYLOR COLLEGE OF MEDICINE | $767,500 | Grant | Trans-NIH Recovery Act Research Support: To study the function of the nuclear receptor LRH-1. The orphan receptor LRH-1/NR5A2 is thought to be a key regulator of the complex process of bile acid biosynthesis and potentially other important metabolic pathways in the liver, but there is very littl | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF IOWA, THE | $750,000 | Grant | Trans-NIH Recovery Act Research Support: Pancreatic involvement is common and the injury progresses to pancreatic insufficiency (PI) in the majority of patients with cystic fibrosis (CF). Currently, there are no treatments to halt the progression of pancreatic disease in CF and the exact mechani | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| NEW YORK UNIVERSITY | $736,856 | Grant | Trans-NIH Recovery Act Research Support: Collectively, these studies will validate the proposed novel concepts towards high strength biomimetic scaffolds. Optimization of the mechanical properties of the newly developed scaffolds will be part of a future application submission. | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $892,838 | Grant | Trans-NIH Recovery Act Research Support: This project will study whether certain pesticides interact with genetic factors in causing Parkinson's disease (PD). PD is a common disease of the nervous system that affects people later in life, causing movement disorders including tremors and freezin | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| NEW YORK UNIVERSITY (INC) | $884,798 | Grant | Trans-NIH Recovery Act Research Support: Emerging technologies for manufacture and use of nanoparticles (NP) are numerous and the exponential increase in their use drives the need for understanding toxicology of these particles. Most non-carbon NP contain one or more toxicologically-active metal | Health and Human Services, Department of / National Institutes of Health | 9/19/2009 |
| OAKLAND UNIVERSITY | $740,000 | Grant | Trans-NIH Recovery Act Research Support: Primary Open-Angle Glaucoma (POAG), the leading cause of blindness in the United States, is characterized by a progressive loss of retinal ganglion cells (RGCs). Elevated intraocular pressure (IOP) is a major risk factor for RGC loss in glaucoma, but the | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $713,071 | Grant | Trans-NIH Recovery Act Research Support: The expression of specific cytochrome P450s (CYPs) in vascular smooth muscle cells and endothelial cells (EC) and the critical contribution of their products to vascular function suggest important roles for these genes in vascular homeostasis. Although la | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON | $744,411 | Grant | Trans-NIH Recovery Act Research Support: The long term objective of this proposal is to gain insights into the neuron generation potential of the mammalian retinal-ciliary margin as well as the molecular and cellular properties of cells within. This has important implications for the regeneratio | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| WASHINGTON UNIVERSITY, THE | $760,000 | Grant | Trans-NIH Recovery Act Research Support: LONG-TERM OBJECTIVE: To gain insight into the cellular and dynamic mechanisms and functional roles of neural feedback loops for visual processing. SPECIFIC AIMS: The aim is to provide an understanding of the dynamic and neural mechanisms of feedback for v | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| GEORGETOWN UNIVERSITY (THE) | $684,870 | Grant | Trans-NIH Recovery Act Research Support: Visual deprivation is one of the most extreme conditions leading brain regions to adopt new functions in response to environmental constraints, that is, to compensate for the loss of a sensory modality. Studies in visually deprived animals and in blind hu | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| BAYLOR COLLEGE OF MEDICINE | $767,500 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this grant is to understand how Notch signaling suppresses the differentiaiton of lens fiber cells. Our recent studies indicate that the Notch signaling pathway inhibits lens fiber cell differentiation. We found that Herp2, a transcripti | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| RFCUNY - CITY COLLEGE | $478,954 | Grant | Trans-NIH Recovery Act Research Support: When one chooses to look at something, one makes a saccadic eye movement to it. Because saccades are so brief, they cannot be guided by visual feedback, but must rely on feedback after each saccade to check the accuracy of that movement and, if needed, to | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $66,465 | Grant | Trans-NIH Recovery Act Research Support: The overall purpose of the project is to examine how kinesin motors interact with microtubules. This work will contribute to our understanding how healthy and cancer cells divide. The findings may suggest new approaches for developing novel chemotherapeut | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $564,961 | Grant | Trans-NIH Recovery Act Research Support: ARRA - Mechanistic Studies of DNA Repair and Damage Response The overall goal of this proposal is to elucidate the structural and dynamic properties of MutSa-DNA complexes that signal initiation of DNA mismatch repair (MMR) versus initiation of DNA dama | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $369,877 | Grant | Trans-NIH Recovery Act Research Support: Biological Properties of HIV-1 V3 Evolutionary Variants (ARRA) This ARRA funded grant is a supplement to the parent grant R37-AI44667 !Biological Properties of HIV-1 V3 Evolutionary Variants!. This funding is accomplishing two important goals relevant to | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF IOWA, THE | $568,017 | Grant | Trans-NIH Recovery Act Research Support: The recycling endosome (RE) is a nexus for membrane transport in both polarized and nonpolarized cells. In polarized cells, endocytic traffic originating on both the apical and basolateral surfaces passes through the recycling endosome. Basolateral secret | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $538,211 | Grant | Trans-NIH Recovery Act Research Support: This proposal will delineate the structural features of a group o f Eph receptors (EphB2, EphA2, and EphA4) in their apo forms as well as in complex with their cognate ligands and peptides. These receptors are members of the largest receptor tyrosine kina | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) | $733,700 | Grant | Trans-NIH Recovery Act Research Support: Currently, there are no specific high-affinity inhibitors or activators of mitochondrial ATP-dependent proteases. The identification of such compounds will allow us to determine the role that these proteases play in mitochondrial dysfunction, which is ass | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $769,945 | Grant | Trans-NIH Recovery Act Research Support: Mastery of written and oral communication skills is essential for the survival of faculty everywhere. It can be a challenge for scientists from any background, but may be especially difficult for those who are educationally under-prepared or who have had | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $480,584 | Grant | Trans-NIH Recovery Act Research Support: Germ cells are specialized cells that undergo mitotic proliferation followed by meiosis and cellular differentiation to generate haploid gametes for sexual reproduction. Errors in human germ cells are quite common and result in a high frequency of spon | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| WASHINGTON UNIVERSITY, THE | $638,302 | Grant | Trans-NIH Recovery Act Research Support: Human- and hominoid-specific genes are among the most interesting genes in the human genome. These genes are likely to have evolved by duplication of segments of DNA ( a process called segmental duplication) that occurred during primate expansion. New gen | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $431,354 | Grant | Trans-NIH Recovery Act Research Support: Inhibition of androgen synthesis is the current treatment of human diseases like prostate cancer and polycystic ovary syndrome. This approach is suboptimal. By defining how the enzyme responsible synthesizes these androgens, we hope to establish new appro | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF IOWA, THE | $519,784 | Grant | Trans-NIH Recovery Act Research Support: Recent advances in the field of structural biology and quantitative proteomics mean that there is now sufficient information available to allow the construction of meaningful, working molecular models of physiological environments. Such environmental mode | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $662,783 | Grant | Trans-NIH Recovery Act Research Support: All living things need sulfur, and cysteine desulfurases are necessary to provide sulfur in the proper form. These enzymes are found primarily in mitochondria in all human cells. Here we aim to characterize for the first time the active mitochondrial cyst | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $749,880 | Grant | Trans-NIH Recovery Act Research Support: We have shown that circulating levels of vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) are elevated in mouse and human models of sepsis, that VEGF plays a pathogenic role in sepsis, and that the upregulation of PlGF represen | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| BAYLOR COLLEGE OF MEDICINE | $970,890 | Grant | Trans-NIH Recovery Act Research Support: 'The roles of the V-ATPase at the molecular and physiological level will be investigated. The V0 sector subunit G?aG? has been shown to play important roles in diverse membrane fusion or secretion functions independent of the V-ATPase proton-pumping activ | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $616,000 | Grant | Trans-NIH Recovery Act Research Support: Spermatogenesis is a complex process where the proliferation/differentiation of germ cells is intimately tied to their apoptosis. How these germ cell corpses are cleared and how this engulfment process links to normal spermatogenesis, are poorly understoo | Health and Human Services, Department of / National Institutes of Health | 7/24/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $638,937 | Grant | Trans-NIH Recovery Act Research Support: The maturation of mathematical reasoning skills is a hallmark of human cognitive and academic development. Cognitive, developmental and educational psychologists have provided valuable insights into the complex and dynamic developmental changes in mental | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| BAYLOR COLLEGE OF MEDICINE | $767,500 | Grant | Trans-NIH Recovery Act Research Support: The goal of this supplement will be to support our studies on the intercellular bridge. Intercellular communication is essential for all multicellular organisms. A unique form of intercellular communication occurs between germ cells; 0.5-3 mm G?channelsG? | Health and Human Services, Department of / National Institutes of Health | 7/29/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $724,891 | Grant | Trans-NIH Recovery Act Research Support: Neonatal jaundice occurs in 60?70% of all newborn infants. It is caused not only by an overproduction of bilirubin, but also by a transient failure to excrete this metabolite. Hyperbilirubinemia is exacerbated by hemolytic diseases, such as Rhesus isoimmu | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF THE SMITH COLLEGE, THE | $199,526 | Grant | Trans-NIH Recovery Act Research Support: In the developing vertebrate central nervous system, radial glial cells play critical roles in supporting brain architecture and, more recently discovered, possess self-renewing capabilities as well as gliogenic and neurogenic potential. Radial glial cell | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| UNIVERSITY OF WASHINGTON | $922,086 | Grant | Trans-NIH Recovery Act Research Support: The broad, long-term objective of this application is to extend our current tool for identifying regions of imminent skin break-down in amputee prothesis users into a more clinically useful tool for prosthetic fitting and modification. In addition to iden | Health and Human Services, Department of / National Institutes of Health | 9/02/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $1,780,906 | Grant | Trans-NIH Recovery Act Research Support: This award, 'Sources of Change and Stability in Low Income Black Marriages,' is funding a longitudinal and observational study of black and white newlywed couples recruited from low-income communities. Couples are interviewed in their home, recorded enga | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $1,319,038 | Grant | Trans-NIH Recovery Act Research Support: The prevalence of autism spectrum disorders (ASD) is now estimated to be 1 in 150, making it a major burden to society. It has been clearly determined that genes play a major role in the etiology of autism, but previous genetic studies | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $1,057,159 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this project is to elucidate how anti- and pro-atherogenic factors modulate nuclear factor (NF)-:B activation to influence vascular inflammation and atherogenesis. A major hypothesis is that extracellular signal-regulated kinase (ERK) | Health and Human Services, Department of / National Institutes of Health | 7/31/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $717,956 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this research is to determine the physiological and pathological roles of the different MLCK isoforms, encoded by the mylk1 gene, in the vasculature. The mylk1 gene encodes a 220kDa myosin light chain kinase (MLCK), a 130kDa MLCK, as | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF PITTSBURGH THE | $1,104,458 | Grant | Trans-NIH Recovery Act Research Support: Pulmonary embolism (PE) affects many, with an estimated incidence of up to 69 cases per 100,000 persons annually. In the U.S., 101,000 patients were hospitalized with a primary diagnosis of PE in 2002, resulting in direct medical costs of $720 million. Ou | Health and Human Services, Department of / National Institutes of Health | 8/07/2009 |
| GEORGETOWN UNIVERSITY (THE) | $1,222,650 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of our research is to develop resources and tools for knowledge retrieval management in the biomedical domain. As the pace of biomedical research accelerates, researchers become more and more dependent on computers to manage the explosi | Health and Human Services, Department of / National Institutes of Health | 8/07/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $1,164,534 | Grant | Trans-NIH Recovery Act Research Support: The objective of this proposal, which is designed to address the ever increasing need for integrated knowledge discovery in biology and medicine, is to enable the discovery, verification, and validation of hypotheses concerning interrelationships between | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $1,641,596 | Grant | Trans-NIH Recovery Act Research Support: As stated in the abstract, the overall goal of the proposed research is to determine if pregnant teenagersG?? life stress and stress related changes in blood pressure (BP), as well as other biological indices of stress (cytokines, HPAG??axis activity) are | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| UNIVERSITY OF IOWA, THE | $1,576,739 | Grant | Trans-NIH Recovery Act Research Support: Schizophrenia is a major mental disorder that strikes in young adulthood and that has a heritability of 80-90%. Even with state-of-the-art treatment, schizophrenia often produces life-long disability, creating a pressing need to delineate the heritable co | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $762,263 | Grant | Trans-NIH Recovery Act Research Support: The understanding of how nervous system activity gives rise to behavior and cognition is being revolutionized by experimentation with molecularly-tractable model species such as zebrafish. These efforts are greatly hampered by the lack of automation in th | Health and Human Services, Department of / National Institutes of Health | 8/12/2009 |
| DUKE UNIVERSITY | $889,200 | Grant | Trans-NIH Recovery Act Research Support: Neuroendocrine or immune events occurring within the perinatal environment often produce effects on brain and behavior that endure throughout an organism's life span. An estimated 1/3 of pregnancies suffer complications involving infection or trauma of th | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| BAYLOR COLLEGE OF MEDICINE | $2,998,515 | Grant | Trans-NIH Recovery Act Research Support: Statement of Purpose (15 words): To identify which genes harbor individual or collections of rare DNA variants predisposing autism. Abstract: We propose a partnership between expert large-scale sequencing centers and a collaborative network of research la | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $431,750 | Grant | Trans-NIH Recovery Act Research Support: Dose of Early Therapeutic Mobility: Does Type and Frequency of Activity Matter? Abstract Early therapeutic mobility (ETM) activity has been recommended to facilitate recovery and improve outcomes, particularly for the one million survivors of critical ill | Health and Human Services, Department of / National Institutes of Health | 4/29/2009 |
| UNIVERSITY OF UTAH, THE | $413,875 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The vertebrate central nervous system (CNS) is patterned by environmental signals that regulate neuronal phenotype and function. Understanding the mechanism of cell differentiation in the nervous system is vital for ou | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $459,980 | Grant | Trans-NIH Recovery Act Research Support: In humans uric acid constitutes a strong antioxidant as well as the end product of purine metabolism. Lower blood uric acid is now emerging as a major molecular risk factor for idiopathic Parkinson's disease (PD). Moreover, our preliminary findings have d | Health and Human Services, Department of / National Institutes of Health | 6/15/2009 |
| WASHINGTON UNIVERSITY, THE | $628,371 | Grant | Trans-NIH Recovery Act Research Support: The ultimate goal of this project is to develop Positron Emission Tomography (PET) imaging agents to measure the level of vesicular acetylcholine transporter (VAChT) expression in the human brain. VAChT is a unique and novel marker for cholinergic neuron | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $475,024 | Grant | Trans-NIH Recovery Act Research Support: Neuroimaging techniques such as MRI, fMRI and PET provide a wealth of quantitative information related to anatomy, function, development, and disease etiology of the nervous system. Experimental studies utilizing neuroimaging techniques have generated and | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $404,980 | Grant | Trans-NIH Recovery Act Research Support: This project is being supported with funds from the American Recovery and Reinvestment Act, which may involve a reduction in the research aims and scope. If necessary, a revised abstract will be posted soon and this notice removed. DESCRIPTION (provided | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| NEW YORK UNIVERSITY (INC) | $481,691 | Grant | Trans-NIH Recovery Act Research Support: Given our long-term goal to discover new therapeutic approaches that can improve patient outcomes, we will investigate a novel therapeutic strategy, intranasal drug delivery, aiming to inhibit the invasion of glioma cells. The proposed studies are the fir | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $998,903 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this project is to develop and implement fout culturally adaptive distance education courses that can enhance productivity and quality of active U.S.-international research and research training collaborations. The courses are being offere | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| THOMAS JEFFERSON UNIVERSITY | $1,980,291 | Grant | Trans-NIH Recovery Act Research Support: This proposal brings together a unique multidisciplinary team of leading experts in alcohol studies and real time dynamic fluorescence imaging of cells and subcellular structures in intact tissues, high resolution electron tomography, sophisticated molecu | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $6,741,000 | Grant | Trans-NIH Recovery Act Research Support: A Grand Opportunity for scientific advance has been created by the confluence of falling costs of genotyping, the development of statistical methods for genome-wide association studies (GWAS), and the creation of a substantial repository of genetic materi | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| PURDUE UNIVERSITY | $1,113,807 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION: Current methods for measuring dietary intake in free-living people typically result in an average under- estimation of energy intake (EI) of 10-50%. Data are suggestive, but not conclusive, that EI underreporting is specific to foods and beve | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE INC | $145,288 | Grant | Trans-NIH Recovery Act Research Support: The goal of the current proposal is to obtain funds for the purchase of a high-resolution ultrasound micro- imaging system designed specifically for non-invasive small animal research. The Visualsonics Vevo 770 offers spatial resolution down to 30 microns | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| PURDUE UNIVERSITY | $968,680 | Grant | Trans-NIH Recovery Act Research Support: The ability to identify protein post-translational modifications (PTMs) in complex biological samples is increasingly important in modern biomedical research. This proposal requests funds for the purchase of a ThermoFisher LTQ Orbitrap XL Mass Spectromete | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $1,996,316 | Grant | Trans-NIH Recovery Act Research Support: Funding is requested for a high resolution 9.4T magnetic resonance (MR) scanner to serve and expedite in vivo animal research at the Dartmouth College and Dartmouth Hitchcock Medical Center (DHMC). The NIH funded research programs that will exploit the MR | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| SOUTH CAROLINA RESEARCH FOUNDATION | $278,000 | Grant | Trans-NIH Recovery Act Research Support: BD BIOSCIENCES LSR II FACS FOR THE UNIVERSITY OF SOUTH CAROLINA This proposal requests $277,596 to purchase a BD Biosciences LSR II FACS system. The system will be housed in the Instrumentation Resource Facility (IRF) of the University of South Carolina S | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $420,055 | Grant | Trans-NIH Recovery Act Research Support: Glycoconjugates play crucial roles in many fundamental biological processes, and changes in glycan structure correlate with certain diseases and disorders. The large number of biological activities attributed to glycans is due in part to their interaction | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $385,700 | Grant | Trans-NIH Recovery Act Research Support: Many physiological parameters affecting human health and disease, including the sleep/wake cycle, core body temperature, hormonal secretion, cardiovascular function, respiration, and metabolism exhibit daily rhythms that are generated by an internal circa | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| OKLAHOMA MEDICAL RESEARCH FOUNDATION | $97,684 | Grant | Trans-NIH Recovery Act Research Support: The immune system is a relevant target for analyzing how cells interpret the myriad of signals they receive through their surface receptors to make decisions regarding their fate and/or functional responses. Alterations in these processes contribute to th | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |