Listing all stimulus spending by amount, in descending order. Return to National Institutes of Health page
Amount refers to both the amount of stimulus funding going toward the project and the face value of the loan.
| Recipient | Amount | Type | Description | Federal Dept./Agency | Date |
|---|---|---|---|---|---|
| GLOBAL VACCINES INC | $92,824 | Grant | Trans-NIH Recovery Act Research Support: The goal of our proposal is to understand how alphavirus replicon particles (nVRPs) function as adjuvants. nVRPs stimulate a protective systemic and mucosal immune response when co-delivered with a target antigen even when delivered at a non-mucosal site. | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $98,210 | Grant | Trans-NIH Recovery Act Research Support: The specific aims of this proposal are: 1) To characterize the metal regulators AdcR and SczA. AdcR regulates the expression of a zinc uptake system in S. pneumoniae that is necessary for virulence and adhesion. I will elucidate using in vivo growth assay | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $100,458 | Grant | Trans-NIH Recovery Act Research Support: As one of the first cells to contact HIV, dendritic cells (DCs) are believed to play a central role in establishing infection and subsequent viral dissemination. All currently defined interactions between HIV and DCs rely upon the HIV Env. Previous work f | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | $475,670 | Grant | Trans-NIH Recovery Act Research Support: The general objective of this project is to upgrade cage wash support service equipment for two satellite buildings housing laboratory animals in the Division of Laboratory Animal Resources at Stony Brook University (SBU). The University has both short an | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| WAKE FOREST UNIVERSITY | $3,489,267 | Grant | Trans-NIH Recovery Act Research Support: Severe asthma, a heterogeneous disease consisting of related clinical phenotypes, generates high levels of morbidity, mortality and health care costs. The complexity and heterogeneity of the disorder have limited clinical advances. However, the NHLBI Seve | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $971,802 | Grant | Trans-NIH Recovery Act Research Support: Congenital cardiac malformation is the most frequent birth defect and it contributes to advanced heart failure in the pediatric and adult population. An enhanced understanding of the transcriptional networks that direct cardiac progenitors during heart de | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| WASHINGTON UNIVERSITY, THE | $959,477 | Grant | Trans-NIH Recovery Act Research Support: The long term goal of this continuing work is to quantitatively characterize skeletal muscle structure and function noninvasively with nondestructive imaging modalities, and to implement robust methods for diagnosing disease and improving clinical managem | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| DUKE UNIVERSITY | $1,273,672 | Grant | Trans-NIH Recovery Act Research Support: Five million patients suffer from heart failure in the United States. Clinical trials of stem cell therapy, initiated because of the severity of this problem, have yielded modest results. Understanding the epigenetic programs that induce differentiation o | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| MEDICAL COLLEGE OF WISCONSIN, INC., THE | $760,000 | Grant | Trans-NIH Recovery Act Research Support: Dahl salt-sensitive rats (SS) exhibit defects in the regulation of their renin-angiotensin system (RAS) that result in chronically low plasma renin activity (PRA) and low circulating ANG II levels, even when they are normotensive and fed a normal salt (NS | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| THE UNIVERSITY OF SOUTH DAKOTA | $813,595 | Grant | Trans-NIH Recovery Act Research Support: Interventions that may stimulate or regulate healthy cardiac vessel growth are of considerable clinical relevance. Research conducted primarily on tumor growth and organ development has identified two major cellular mechanisms of angiogenesis: sprouting a | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $718,754 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Soluble growth factors play a vital role in virtually all tissue development and regeneration processes, and inductive growth factors are critical components of many emerging tissue engineering strategies. However, app | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $1,375,000 | Grant | Trans-NIH Recovery Act Research Support: Extracellular nucleotides (ATP, ADP and UTP) are known to activate type-2 purinergic (P2Y and P2X) receptors on platelets, endothelium and immune cells to induce vascular inflammation and thrombosis. Cellular ectonucleotidases hydrolyze P2-mediators to do | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF PITTSBURGH THE | $757,500 | Grant | Trans-NIH Recovery Act Research Support: Global and regional epigenetic changes, including CpG dinucleotide methylation and de-methylation, in response to environmental cues, have been implicated in a growing number of human diseases including various cancers, rheumatic and autoimmune diseases, | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $1,009,890 | Grant | Trans-NIH Recovery Act Research Support: Atherosclerosis is a chronic disease characterized by lipid infiltration and inflammatory cell recruitment in the vessel wall that can lead to serious clinical consequences such as myocardial infarction and stroke. While of the role of monocytes and T lym | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| WASHINGTON UNIVERSITY, THE | $1,119,787 | Grant | Trans-NIH Recovery Act Research Support: Diabetes is associated with serious cardiovascular complications that include heart failure. Data from studies conducted in animal models and human subjects suggest that alterations in fatty acid metabolism, independent of atherosclerosis, are involved in | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $788,415 | Grant | Trans-NIH Recovery Act Research Support: Ion channels use the energy stored in ionic gradients to initiate rapid signaling events essential for the function of virtually every cell in the body. Although channel activation can occur in response to a variety of different stimuli, once open all cha | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $1,610,696 | Grant | Trans-NIH Recovery Act Research Support: Investigators in many biomedical research areas?from post-marketing surveillance of adverse drug events to biomarker studies of gene-expression data to outcomes analyses of healthcare interventions?have a common need to extract clinically or biologically | Health and Human Services, Department of / National Institutes of Health | 5/27/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $1,282,149 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): To enhance participant recruitment efforts for genetics studies and other large- scale etiological research efforts, there is a need for an instrument that can be practically and efficiently employed in research studie | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| RUSH UNIVERSITY MEDICAL CENTER | $744,009 | Grant | Trans-NIH Recovery Act Research Support: Convention suggests that the blood brain barrier (BBB) prevents certain drugs and neurotoxins from gaining access to dopamine (DA) neurons in patients with ParkinsonG??s disease (PD) unless a specific transport mechanism exists. However, we showed in ani | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | $216,437 | Grant | Trans-NIH Recovery Act Research Support: The overall aim of this project is to clarify the relationship between neuronal activity in the internal segment of the globus pallidus (GPi) and the development, phenotypic distribution and severity of dystonic movements in patients with primary generali | Health and Human Services, Department of / National Institutes of Health | 9/26/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $1,060,250 | Grant | Trans-NIH Recovery Act Research Support: Inflammation can augment dramatically the sensitivity of nociceptive sensory neurons. In some cases, the actions of inflammatory mediators are fairly well understood; however, there are signaling pathways for which we have very little knowledge. Such a pa | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| THOMAS JEFFERSON UNIVERSITY | $742,525 | Grant | Trans-NIH Recovery Act Research Support: In the dopaminergic neurons, free dopamine in the cytosol is a unique source of endogenous toxins leading to neuron death; however, dopamine of physiological concentration is not sufficient to cause cell death. Dopamine may become toxic when other risk fa | Health and Human Services, Department of / National Institutes of Health | 7/27/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $906,637 | Grant | Trans-NIH Recovery Act Research Support: Stroke continues to be the leading cause of long-term disability among adults and its prevalence will continue to rise as the population ages. Developing analytical strategies for improving quality of life and independence following stroke are of tall imp | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| NORTHWESTERN UNIVERSITY | $137,250 | Grant | Trans-NIH Recovery Act Research Support: Hyperglycemia in diabetes leads to kidney damage that may ultimately culminate in end stage renal disease (ESRD), the most severe stage of chronic kidney disease. ESRD patients must rely on frequent hemodialysis treatments to extend life. Some ESRD patien | Health and Human Services, Department of / National Institutes of Health | 5/01/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $148,416 | Grant | Trans-NIH Recovery Act Research Support: This grant provides RO3 level funding to develop mitochondrial transfection of African trypanosomes. Humans exhibit an innate immunity to the mammalian parasite Trypanosoma brucei brucei. Trypanosoma brucei is the causative agent of African human sleeping | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, THE | $453,595 | Grant | Trans-NIH Recovery Act Research Support: Septic shock and septic multiple organ dysfunction/injury (MOD/I) are serious clinical syndromes that claim thousands of lives each year in the U.S. This research project is aimed at identifying new mechanisms and elucidating new molecular pathways that | Health and Human Services, Department of / National Institutes of Health | 6/11/2009 |
| HEALTH RESEARCH, INC. | $434,223 | Grant | Trans-NIH Recovery Act Research Support: The long term objective of this proposal is to address the role of IFN??signaling in the regulation of CD4 T cell responses during Mtb infection. Using a well-established mouse model of tuberculosis we will test the hypothesis that IFN??acts directly on C | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $403,521 | Grant | Trans-NIH Recovery Act Research Support: Candida albicans is the most frequently isolated fungal pathogen of humans. This fungus can switch between three distinct morphological forms: yeast, hyphae, and pseudohyphae. The reversible transition between the unicellular (yeast) and filamentous (pseu | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $410,720 | Grant | Trans-NIH Recovery Act Research Support: Vibrio species are predominantly aquatic bacteria. While many of them are nonpathogenic, some vibrios are associated with severe disease in humans. Vibrio cholerae, in particular, has a long history of causing epidemic and pandemic cholera. Cholera result | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $404,164 | Grant | Trans-NIH Recovery Act Research Support: This project will study the molecular conformation changes of viral proteins during interaction with a target cell membrane using cryo-electron microscopy and 3D image reconstruction techniques. | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $408,375 | Grant | Trans-NIH Recovery Act Research Support: Toxoplasma gondii is a pathogenic protozoan parasite infecting a wide range of vertebrate hosts including humans. In immunocompetent individuals, infection is largely asymptomatic and is controlled by the host's immune response. However, T. gondii has als | Health and Human Services, Department of / National Institutes of Health | 7/23/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $451,000 | Grant | Trans-NIH Recovery Act Research Support: A. phagocytophilum and NF-kB signaling. This project will investigate how Anaplasma phagocytophilum influences proinflammatory cellular mechanisms by impacting NF-kB activation. The specific pre-nuclear mechanisms targeted in the generation of active NF-k | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $522,225 | Grant | Trans-NIH Recovery Act Research Support: Hepatitis C virus (HCV) chronically infects 2-3% of the global population, predisposing the patients to chronic liver diseases and liver cancer. The most effective treatment for HCV infection employs a combination of pegylated interferon-alpha (IFN-a) and | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $466,125 | Grant | Trans-NIH Recovery Act Research Support: ): For most infections, the immune system confers long-term and sometimes life-long protection against many microbial pathogens. One encounter with a microbial pathogen is sufficient to allow the immune system to remember this pathogen for decades to come | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF NEW MEXICO | $412,500 | Grant | Trans-NIH Recovery Act Research Support: Mycobacterium tuberculosis latently persist in 2 billion people, representing a major reservoir of tuberculosis (TB) due to reactivation, yet the state of latent bacilli remains a mystery. In order to eradicate TB, we need to understand latency and develo | Health and Human Services, Department of / National Institutes of Health | 6/19/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $903,834 | Grant | Trans-NIH Recovery Act Research Support: Advancing Diffusion Tensor Imaging and Analyses for Basic Alcohol Research - ARR. The purpose of this project is to rapidly advance DTI technology and its application to discovery and documentation of alcohol?s deleterious effects on the pre-and postnatal | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF MIAMI | $948,933 | Grant | Trans-NIH Recovery Act Research Support: As the population of the United States ages, there is an increased risk of cognitive impairment and physical deconditioning. Physical exercise has been shown to have physical and health benefits in the elderly and there is increasing evidence that systema | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $787,301 | Grant | Trans-NIH Recovery Act Research Support: Purpose: The principal objective of the proposed research is to define the cellular pathogenic mechanisms of fragile X-associated tremor/ataxia syndrome (FXTAS), one of the leading known single-gene forms of late-onset neurodegeneration. FXTAS shares many | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| CHILDRENS HOSPITAL OF PHILADELPHIA | $420,000 | Grant | Trans-NIH Recovery Act Research Support: Most strategies to increase marrow production of platelets have focused on use of positive cytokines such as thrombopoietin (TPO). We have recently described an important inhibitory loop that also regulates platelet counts. We found that at least one chem | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $995,182 | Grant | Trans-NIH Recovery Act Research Support: This project, entitled ?Epidemiology and Mechanisms of Accelerated Aging in HIV Infection,? addresses broad Challenge Area (05) Comparative Effectiveness Research and specific Challenge Topic, 05-AI-101: Accelerated Aging in Treated vs. Untreated HIV/AIDS | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $959,446 | Grant | Trans-NIH Recovery Act Research Support: The development and maintenance of memory T cells is a hallmark of the host response to acute and persistent viral infections and a major objective of vaccination for infectious diseases and cancer. Progress in defining the qualitative attributes of memo | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $972,262 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (05) Comparative Effectiveness Research, and specific Challenge Topic 05-AI-102: Comparative-effectiveness of Anti Retroviral Therapy (ART). We propose to assess the comp | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| SOUTHERN RESEARCH INSTITUTE | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: Highly drug resistant forms of tuberculosis termed multidrug resistant (MDR) and extensively drug resistant (XDR) tuberculosis are on the rise worldwide raising the specter that this disease may once again become virtually incurable. | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF WASHINGTON | $927,226 | Grant | Trans-NIH Recovery Act Research Support: The focus of this grant is to establish Drosophila melanogaster as a model system to study sphingolipid signaling as it relates to muscle regeneration as well as to test a wunen/LPP3 based strategy that suggested itself from our studies in Drosophila to a | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $919,028 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (06) Enabling Technologies and specific Challenge Topic 06- AT-101*: Imaging correlates of brain states. Project Summary: Our goal is to determine the functional brain ne | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| DUKE UNIVERSITY | $2,941,248 | Grant | Trans-NIH Recovery Act Research Support: The fundamental roles of innate and adaptive host responses are to recognize and eradicate invading antigens, pathogens or altered self components with the purpose of restoring tissue integrity and homeostasis. While resolution can occur when the host re | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| MAYO CLINIC | $2,500,008 | Grant | Trans-NIH Recovery Act Research Support: The Mayo Clinic Center for the Individual Treatment of Alcohol Dependence (CITA) is a P20 exploratory/ developmental alcohol research center proposal with the over-arching theme of using translational research strategies to create a new research center wi | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $302,235 | Grant | Trans-NIH Recovery Act Research Support: Hopkins Center for Population Aging and Health: An emerging consensus calls for the development of new interdisciplinary research within public health that integrates divergent perspectives, frameworks and methods. The HCPAH will be an interdisciplinary r | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF WASHINGTON | $400,000 | Grant | Trans-NIH Recovery Act Research Support: The mission of the Northwest Roybal Center (NRC) is to improve the health, well being, quality of life and productivity of older adults with cognitive impairment, midlife and older adults at risk for cognitive impairment, and their caregivers through the | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $1,230,852 | Grant | Trans-NIH Recovery Act Research Support: Early Stage Investigator Recruitment in Cancer Research This proposal was submitted to fund the recruitment of a basic scientist who would be incorporated into the translational science programs of the UNC-Lineberger Comprehensive Cancer Center. The gra | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $877,836 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This application is in response to RFA-OD-09-005, title 'Recovery act limited competition: Supporting new faculty recruitment to enhance research resources through biomedical research core centers (P30). The Neurobiolo | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $999,446 | Grant | Trans-NIH Recovery Act Research Support: The long- term objective of this project is to use new technologies to sensitively measure, automatically analyze and efficiently manage clinical trial data for Parkinson's disease (PD) and other neurological disorders. This project will focus on developi | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON | $962,400 | Grant | Trans-NIH Recovery Act Research Support: People expect their primary care physician to be their point of access to healthcare and to assure that the care they receive within the system is evidence-based, cost-effective, coordinated, and safe. Unfortunately, primary care providers do not have the | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| THE VANDERBILT UNIVERSITY | $985,151 | Grant | Trans-NIH Recovery Act Research Support: We are proposing to evaluate the efficacy of the sustained Vanderbilt University-Metropolitan Nashville Public Schools-Tennessee State University-Meharry Medical College-Fisk University GK12/Scientist in the Classroom Program (SCP) on the long-term impact | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $1,100,000 | Grant | Trans-NIH Recovery Act Research Support: We propose to study US trends in the prevalence of cognitive impairment and dementia by performing a new Aging, Demographics, and Memory Study (ADAMS 2010) that uses a similar methodology to that employed for the original NIA-funded study performed in 200 | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $1,347,232 | Grant | Trans-NIH Recovery Act Research Support: Age-related illnesses present major public health challenges due to their increasing prevalence, associated disability and current lack of effective therapies. The broad, long-term goal of this project is to understand the role of aging physiology, and pa | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $1,096,941 | Grant | Trans-NIH Recovery Act Research Support: The proposal brings together the complementary strengths of three labs to develop and test a new set of molecular tools that will globally report on the health of the proteome during aging. These groups form the Proteostasis Aging Sensor Consortium (PASC) | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| OKLAHOMA MEDICAL RESEARCH FOUNDATION | $4,299,997 | Grant | Trans-NIH Recovery Act Research Support: Genome-wide association scans (GWAS) in human SLE have identified DNA segments that likely harbor causal variants, however, the precise identities of these variants have remained elusive. The primary objective of this 'Grand Opportunity' proposal is to d | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, THE | $2,490,569 | Grant | Trans-NIH Recovery Act Research Support: In order to make these studies possible, the scientific community will require the repeated participation of a large numbers of normal subjects who carry polymorphisms of interest and are willing to be studied. This proposal will make such a population re | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRANSDERM, LLC | $2,760,000 | Grant | Trans-NIH Recovery Act Research Support: The broad potential for using nucleic acids to treat human disease has not been realized. Delivery of nucleic acids for the purpose of regulating gene expression in cultured cells has been routine in many laboratories for twenty years. Over 350 rare monog | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $2,824,336 | Grant | Trans-NIH Recovery Act Research Support: Over the past several years, there has been a dramatic increase in the scientific scrutiny of omega-3 fatty acids and their impact on health. Results indicate that omega-3 fatty acids have potent anti-inflammatory actions. Inflammation is at the root of m | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $546,484 | Grant | Trans-NIH Recovery Act Research Support: Head and Neck Squamous Cell Carcinoma (HNSCC) is a disease with significant morbidity and mortality, and without reliable indicators for prognosis, local recurrence, or presence of premalignant disease. This project is focused on validation of epigenetic, | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $2,483,116 | Grant | Trans-NIH Recovery Act Research Support: For this ARRA RFA-OD-09-004 GO application, we propose to perform an integrated genome-wide mutational analysis of oral cancers using high throughput sequence analysis of coding genes combined with analyses of copy number, gene expression, and methylation | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF ILLINOIS | $1,798,070 | Grant | Trans-NIH Recovery Act Research Support: Previous studies in rats have provided evidence that brief, early-life exposures to bisphenol A (BPA) at environmentally relevant doses results in developmental reprogramming of the prostate gland via epigenetic modifications that enhance carcinogenic sus | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF KENTUCKY | $6,000,000 | Grant | Trans-NIH Recovery Act Research Support: Medicinal plants produce a wealth of pharmaceutical compounds such as taxol, vincristine, and morphine. Unfortunately, the specialized secondary metabolic pathways leading to such compounds remain poorly understood and progress in elucidating and manipula | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON | $2,008,515 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this initiative is to investigate the cellular uptake, trafficking, and sub-cellular localization of different classes and subtypes of nanoparticles (NPs) with well-defined physiochemical properties for the creation of a reference tabl | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $7,300,907 | Grant | Trans-NIH Recovery Act Research Support: Exploration with DNA chips of the genomeG??s activity holds great potential for human health. Using a combination of high-throughput genomics and computational biology, we will perform a broad exploration of gene expression in human blood cells. Distinct | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $2,021,390 | Grant | Trans-NIH Recovery Act Research Support: Neonatal apnea, or apnea of prematurity, is the most common serious disorder of premature infants in the neonatal intensive care unit (NICU). There are significant gaps in knowledge in its definition, documentation and management. For example, despite con | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| BROAD INSTITUTE, INC., THE | $1,218,671 | Grant | Trans-NIH Recovery Act Research Support: Next-generation sequencing produces huge amounts of data that require significant investments in computation resources and data storage to convert sequencing instrument output into biomedical knowledge. Such large data center investments can prove to be | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $3,990,588 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This application responds to NHGRI's call for Medical Sequencing Discovery Projects that will use next-generation sequencing technology to tackle high-impact challenges in medical genetics. We propose to build on our s | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON | $2,766,567 | Grant | Trans-NIH Recovery Act Research Support: This proposal responds to the GO Program 'ARRA Medical Sequencing Discovery Projects' to establish next-generation technologies for medical resequencing in smaller academic laboratories compared to larger facilities like the Genomic Sequencing Centers. In | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA MERCED | $1,302,415 | Grant | Trans-NIH Recovery Act Research Support: The proposed National Center on Minority Health and Health Disparities Center of Excellence (NCMHD COE)for the Study of Health Disparities in Rural and Ethnic Underserved Populations at the University of California, Merced (UC Merced)will develop a sustai | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $1,299,657 | Grant | Trans-NIH Recovery Act Research Support: This proposal will support a novel partnership between a community-based organization (Arthur Ashe Institute of Urban Health), a government agency (Office of the Brooklyn Borough President) and an academic research institution (Downstate Medical Center) | Health and Human Services, Department of / National Institutes of Health | 9/19/2009 |
| J.DAVID GLADSTONE INSTITUTES, THE | $1,728,000 | Grant | Trans-NIH Recovery Act Research Support: The Gladstone Institute of Neurological Disease (GIND) at he University of California, San Francisco (UCSF) uses an interdisciplinary teann approach to the investigation of neurodegenerative disorders. Alzheimer's disease (AD) is the main cause of aging-r | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF CONNECTICUT | $916,110 | Grant | Trans-NIH Recovery Act Research Support: The work to be conducted by this newly hired faculty member will directly address one of the most serious public health problems in the US, alcohol-related illness and injury. Behavioral therapies have been shown to be effective in controlled laboratory s | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF CHICAGO, THE | $775,981 | Grant | Trans-NIH Recovery Act Research Support: The overall aim of this P30 proposal to the National Institute of Aging is to enhance the capability of the University of Chicago to perform research on how the social context of older persons - whether personal socioeconomic and health factors, family, o | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $804,917 | Grant | Trans-NIH Recovery Act Research Support: Completing the Aims of this P30 Neurodegenerative Disease Core Center will build further the multidisciplinary community of neurodegenerative disease researchers at PENN by recruiting two new faculty members whose expertise complements existing PENN progr | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF WASHINGTON | $1,390,499 | Grant | Trans-NIH Recovery Act Research Support: Understanding the basis of addiction requires insights at every level of neuroscience from defining the initial drug responses, the adaptive changes in cellular function resulting from drug exposure, the learning and memory plasticity changes at the neura | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: The Assessment of Local Environmental Risk Training (ALERT) to Reduce Health Disparities responds to the need for building the capacity of community based organizations (CBOs) to actively participate as equal partners in research projects and the need to | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| YALE UNIVERSITY | $969,272 | Grant | Trans-NIH Recovery Act Research Support: It is the premise of this Challenge Grant that investigations of the dynamics of membrane structure and function would be tremendously facilitated by the development of robust methods for the manufacture of suspended bilayers that are surrounded on both s | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $1,995,177 | Grant | Trans-NIH Recovery Act Research Support: The long-term objective of this Program Project is to perform a systematic analysis of the cellular and molecular mechanisms regulating thymic epithelial cell (TEC) homeostasis and the role of TECs in the involution of the adult thymus. The thymus is the | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $785,000 | Grant | Trans-NIH Recovery Act Research Support: The objective of this proposal is to recruit two tenure track Assistant Professor RNA biologists, one who specializes in bioinformatics and one who specializes in genomic approaches to the study of non-coding RNAs, to join and complement the faculty of th | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE | $1,300,399 | Grant | Trans-NIH Recovery Act Research Support: The mission of the Tulane Hypertension and Renal Center of Excellence (THRCE) is to stimulate research activities related to cardiovascular, kidney, and hypertension related diseases and is a multidisciplinary Center with members from clinical and basic s | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $1,565,800 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This is an application in response to RFA-Recovery Act Limited Competition: Supporting New Faculty Recruitment to Enhance Research Resources through Biomedical Research (P30) ~ to provide support for recruitment of a j | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| BIOMEDICAL RESEARCH INSTITUTE OF NEW MEXICO | $255,927 | Grant | Trans-NIH Recovery Act Research Support: VA Progress Report, Second Quarter 2012 ? Dr. Cynthia Geppert, MD, PhD, MPH ?A Survey Study of Informed Consent Processes in Addiction Treatment? The second and final quarter of the study focused on closing the study with the IRB and preparing manuscript | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $451,000 | Grant | Trans-NIH Recovery Act Research Support: The aim of the study is to examine racial differences in sexual partner characteristics and determine whether neighborhood drug markets influence sex partner characteristics and sexually transmitted infections (STI) status of non-illicit drug using Africa | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| GEORGE MASON UNIVERSITY | $406,417 | Grant | Trans-NIH Recovery Act Research Support: The title of the Award is 'Estimating the Price Elasticities of Demand for Illicit Drugs'. The purpose is understand how illicit drug users change their purchasing behavior when the price(s) of drugs changes. | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| NATIONAL DEVELOPMENT AND RESEARCH INSTITUTES, INC. | $413,325 | Grant | Trans-NIH Recovery Act Research Support: We are developing an innovative Staying Safe Intervention based on the strategies and practices of long term IDUs who have managed to remain uninfected not only with HIV but also with Hepatitis C (HCV). This study will test the efficacy of such an interve | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| RESEARCH TRIANGLE INSTITUTE | $568,481 | Grant | Trans-NIH Recovery Act Research Support: This project will develop the chemical tools that will enable researchers to study certain proteins in the body to better understand their reactions to various chemicals and interactions with each other. By understanding these protein interactions, improv | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| WASHINGTON UNIVERSITY, THE | $303,634 | Grant | Trans-NIH Recovery Act Research Support: The global aim of this project, proposed under the R21 exploratory/developmental mechanism, is to examine the interplay between genetic factors for substance dependence and the age at onset of drinking or smoking, while advancing our understanding of the | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $412,084 | Grant | Trans-NIH Recovery Act Research Support: The development of tolerance to opioids limits their effectiveness for the treatment of pain. A wide variety of opioids that are commonly used in the clinic for the treatment of pain and drug addiction have dramatically different pharmacological propertie | Health and Human Services, Department of / National Institutes of Health | 4/29/2009 |
| UNIVERSITY OF NORTHERN COLORADO | $376,543 | Grant | Trans-NIH Recovery Act Research Support: Injection drug use (IDU) is a major public health problem that is associated with a host of medical complications, including blood-borne viral disease (e.g., HIV, Hepatitis C) and bacterial infections (e.g., skin abscesses, endocarditis) that often result | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $451,000 | Grant | Trans-NIH Recovery Act Research Support: This award is supporting a single project concerning drug abuse, risky decision-making and HIV/AIDS. In addition to the sharing of intravenous injection equipment, another major contribution of drug dependence to HIV risk involves the association of cocai | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF KENTUCKY | $371,250 | Grant | Trans-NIH Recovery Act Research Support: The support cells of the olfactory epithelium have received little direct attention, yet several lines of evidence indicate that they are critical for maintaining or regulating the olfactory sensory nerve cells, the ongoing replacement of olfactory sensor | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $578,049 | Grant | Trans-NIH Recovery Act Research Support: Profound impairment in social interaction is a hallmark of autism spectrum disorders (ASD). Although improvement in social functioning is widely considered to be a crucial target for intervention, social skills treatments for school-age children have been | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $534,149 | Grant | Trans-NIH Recovery Act Research Support: Autism is a lifetime disorder, but surprisingly little is known about the effects it has on the individual's abilities, needs, and experiences as he or she reaches and continues through adulthood. The first descriptions of autism spectrum disorders (ASDs) | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF ILLINOIS | $383,364 | Grant | Trans-NIH Recovery Act Research Support: The risks and potential harms associated with participation in survey research are virtually unknown. Previous work has documented emotional distress in subjects with existing emotional vulnerabilities, although the severity and duration of this distress | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UMDNJ-ROBERT WOOD JOHNSON MEDICAL SCHOOL | $423,960 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): It is now accepted that Multiple Sclerosis (MS) is not just an inflammatory demyelinating but also a degenerative disease of the central nervous system (CNS) with early axonal transection, followed by neuronal loss as | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $410,677 | Grant | Trans-NIH Recovery Act Research Support: Iron accumulates in brain regions that undergo degeneration in several neurodegenerative diseases such as Alzheimer disease (AD) and Parkinson disease (PD) (1-3). However, the precise role of iron in the neurodegenerative process is unclear. The long term | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| DUKE UNIVERSITY | $429,000 | Grant | Trans-NIH Recovery Act Research Support: Malignant glioma is characterized by early local invasion, microsatellite infiltration of healthy CNS tissue and dispersion of tumor cells in distant parenchyma. These characteristics significantly hamper the success of surgical or radiation treatment, si | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $435,741 | Grant | Trans-NIH Recovery Act Research Support: An Interactive Web-Based Game for Collaborative Labeling of Medical Images. The proposed research investigates extension of established practices for volumetric labeling and web-based collaboration to create an innovative infrastructure for labeling. A us | Health and Human Services, Department of / National Institutes of Health | 6/15/2009 |
| UNIVERSITY OF MASSACHUSETTS | $370,878 | Grant | Trans-NIH Recovery Act Research Support: Live-cell imaging has become a valuable analytical tool in most biomedical laboratories, as well as a routine methodology used in wide ranging fields of neurobiology, developmental biology, pharmacology, etc. The phase contrast microscope has been widely | Health and Human Services, Department of / National Institutes of Health | 9/02/2009 |
| EMORY UNIVERSITY | $338,529 | Grant | Trans-NIH Recovery Act Research Support: Title: Analysis of Ubiquitinated Proteome Like phosphorylation, protein ubiquitination is a reversible process to regulate essentially all cellular events. Misregulation of ubiquitination plays an important role in the pathogenesis of a variety of diseas | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| BIOMIMETIC SYSTEMS, INC. | $128,005 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to develop a sonar system that can be used as a mobility aid by the visually impaired. The system will consist of an ultrasonic acoustic source using a waveform that is designed to optimize target discrimination and a pair of m | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| RED HILL STUDIOS | $196,089 | Grant | Trans-NIH Recovery Act Research Support: Red Hill Studios and the University of California San Francisco (UCSF) propose to develop a computer-based therapeutic program for children with Cerebral Palsy (CP). The computer game will include movements that are based on existing therapy models that h | Health and Human Services, Department of / National Institutes of Health | 8/07/2009 |
| HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY M | $69,035 | Grant | Trans-NIH Recovery Act Research Support: A major impediment to successful treatment of Staphylococcus aureus is its tendency to develop antibiotic resistance. Methicillin-resistant Staphylococcus aureus (MRSA) has become a household word in the U.S., with recent outbreaks occurring among otherwi | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| WASHINGTON STATE UNIVERSITY | $140,649 | Grant | Trans-NIH Recovery Act Research Support: Our ability to explain and control the adhesion of Listeria monocytogenes to surfaces is limited by the lack of molecular-scale studies on how the surface biopolymers of L. monocytogenes affect their attachment to surfaces. My long-term goal is to underst | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| AUBURN UNIVERSITY | $76,451 | Grant | Trans-NIH Recovery Act Research Support: Giardia is an important cause of diarrheal disease in humans and other animals. Safer and more effective therapies are needed. We propose in this research to evaluate several candidate compounds (in addition to SP 1020 - our lead compound). To date we hav | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF WASHINGTON | $146,560 | Grant | Trans-NIH Recovery Act Research Support: Our ultimate goal is to develop a general protocol that will define bacterial adhesion receptor:ligand interactions, in their native states as a function of fluid shear - for both pure and mixed culture biofilms. With NIH support, we will develop this pro | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $154,000 | Grant | Trans-NIH Recovery Act Research Support: Invasive aspergillosis (IA) is an important cause of respiratory and disseminated infection in immunocompromised patients, and the most common cause of infectious pneumonic mortality in recipients of hematopoietic stem cell transplants. Mortality from IA | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| UNIVERSITY OF MARYLAND | $150,000 | Grant | Trans-NIH Recovery Act Research Support: Deterioration of cartilage in adults due to trauma or disease is a major health issue in industrialized nations. Because cartilage lacks a regenerative ability, the therapeutic approach of creating cartilage implants in vitro has recently been put forward | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| CEDARS-SINAI MEDICAL CENTER | $162,500 | Grant | Trans-NIH Recovery Act Research Support: Degenerative disc disease and its associated chronic lower back pain is a major U.S. health problem with estimated costs of up to $50 billion yearly. Despite decades of research, a fundamental, multidisciplinary mechanistic understanding of disc degenerat | Health and Human Services, Department of / National Institutes of Health | 5/04/2009 |
| NEW YORK UNIVERSITY (INC) | $169,000 | Grant | Trans-NIH Recovery Act Research Support: Dermal fibrosis is a hallmark of systemic sclerosis. We have previously demonstrated that stimulation of adenosine A2A receptor promotes collagen production in vitro while blockade of the adenosine A2A receptor attenuates development of dermal fibrosis in | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC. | $167,000 | Grant | Trans-NIH Recovery Act Research Support: With the growing cohort of cancer survivors now numbering 11 million Americans, appropriate follow-up care is pivotal to their ongoing long-term health. Despite guidelines regarding surveillance for recurrence and monitoring of toxicities and late effects | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| GEORGETOWN UNIVERSITY (THE) | $153,000 | Grant | Trans-NIH Recovery Act Research Support: Diet-induced obesity, insulin (INS) resistance, and type 2 diabetes have reached epidemic proportion among women in the United States, and each of these health problems significantly increase a woman's risk of developing breast cancer. Studies linking exp | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF MISSISSIPPI | $143,084 | Grant | Trans-NIH Recovery Act Research Support: In recent years new psychoactive plants and their active secondary metabolites have been emerging on the streets. An example is the strong hallucinogenic mint Salvia divinorum and its active metabolite salvinorin A. This use of new hallucinogens unregulat | Health and Human Services, Department of / National Institutes of Health | 4/29/2009 |
| UNIVERSITY OF NEBRASKA | $144,900 | Grant | Trans-NIH Recovery Act Research Support: Tissue engineering involves time- and sequence-dependent procedures where the final outcome is unknown until the restored tissue is formed and functioning. Monitoring changes in the biomechanical properties during tissue development, maturation, ageing, a | Health and Human Services, Department of / National Institutes of Health | 6/10/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON | $150,000 | Grant | Trans-NIH Recovery Act Research Support: Proton magnetic resonance spectroscopic imaging (MRSI) allows the in vivo determination regional distribution of various neurochemicals. The pathologic specificity and inherently quantitative information provided by MRSI should help understand the mechani | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | $157,000 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Patient motion is a major issue in nuclear medicine imaging studies, which require substantial time to acquire enough counts to produce clinical-quality images. Motion correction algorithms exist but have limited accur | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| THE GEORGE WASHINGTON UNIVERSITY | $156,417 | Grant | Trans-NIH Recovery Act Research Support: The pre-placodal ectoderm (PPE) gives rise to the sensory organs in the vertebrate head, which frequently are subject to congenital defects and damage. In animal models, it has been demonstrated that the expression of the transcription factor Six1 is requ | Health and Human Services, Department of / National Institutes of Health | 4/30/2009 |
| UNIVERSITY OF IOWA, THE | $150,000 | Grant | Trans-NIH Recovery Act Research Support: Group B Streptococci (GBS) has emerged as one of the most important infectious causes of neonatal morbidity and mortality and pregnancy-related morbidity. A GBS infection in the pregnant patient places the mother and child at high risk for complications. | Health and Human Services, Department of / National Institutes of Health | 5/11/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $135,754 | Grant | Trans-NIH Recovery Act Research Support: The health and nutrition of young children is of importance not only for the immediate improvement in their well-being but also because of the longer-term impacts on children's physical and cognitive development. It is believed that improvements in cognit | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF NOTRE DAME DU LAC | $165,461 | Grant | Trans-NIH Recovery Act Research Support: This project will explore how historic changes in young women?s access to oral contraception affected the health of women and their children. During the 1960s and 1970s, most states changed the age at which young unmarried women could obtain a prescriptio | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $173,417 | Grant | Trans-NIH Recovery Act Research Support: Chronic obstructive pulmonary disease (COPD) has been increasing for the past years. Today COPD is the most common cause of death in the US and is classified amongst the top five killers. Other lung diseases such as atopic asthma have been steadily increa | Health and Human Services, Department of / National Institutes of Health | 5/06/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $146,438 | Grant | Trans-NIH Recovery Act Research Support: Idiopathic pulmonary fibrosis (IPF) is a chronic lung disorder resulting in progressive respiratory insufficiency and lung fibrosis with fatal outcome. The pathogenesis of IPF remains unclear. Focal-adhesion-kinase-related non-kinase (FRNK) is an endogeno | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| MAYO CLINIC | $151,100 | Grant | Trans-NIH Recovery Act Research Support: Novel therapeutic targets for the treatment of chronic obstructive pulmonary disease (COPD) are urgently needed, as the incidence of COPD - a chronic inflammatory lung disease that imposes tremendous economic burden on the health care system - is increasi | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| CALVIN COLLEGE | $223,050 | Grant | Trans-NIH Recovery Act Research Support: Glucose uptake is mediated by a family of glucose transporters known as GLUT. Insights into how the activity of these transporters is regulated is important for a better understanding of metabolic disorders such as diabetes and metabolic syndrome where gl | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| MIDWESTERN UNIVERSITY | $211,141 | Grant | Trans-NIH Recovery Act Research Support: This Academic Research Enhancement Award (AREA) grant titled 'Role of the abg Locus of E. coli in Folate Catabolism' was funded July 17, 2009. The overall goal is to involve health professional students in research of the genes and proteins of the abg reg | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF ILLINOIS | $216,150 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The inferior olivary nucleus (ION) is one of the principle inputs into cerebellar Purkinje cells and is involved in regulating movement and gaze. Defects in ION formation have been documented in association with a numb | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| IDAHO STATE UNIVERSITY | $213,417 | Grant | Trans-NIH Recovery Act Research Support: Channelopathies, genetic disorders in brain and muscle ion channels, are useful to investigate the structural determinants of channel neuronal and skeletal muscle sodium channels to determine the mechanisms for channel functions not well understodd, inclu | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| KENT STATE UNIVERSITY | $213,715 | Grant | Trans-NIH Recovery Act Research Support: During sexual differentiation, an animal's body and brain develop toward a male or female pattern. According to a model established in rodents, this process is hypothesized to occur because of differential exposure to gonadal secretions. For example in ma | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| EAST TENNESSEE STATE UNIVERSITY | $386,504 | Grant | Trans-NIH Recovery Act Research Support: Chlamydia trachomatis, the most common bacterial sexually transmitted disease (STD) agent worldwide, often establishes asymptomatic genital infections which result in serious reproductive complications. In culture, environmental stressors can induce chlam | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | $392,500 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Many systemic autoimmune diseases are more common in females than in males. This is particularly evident in Sjvgren's Syndrome, systemic lupus erythromatosis (SLE) and thyroid autoimmunity, where the ratio of females t | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $446,875 | Grant | Trans-NIH Recovery Act Research Support: Alcohol consumption is generally thought to enhance liver fibrosis. Alcohol-induced liver fibrosis promotes formation of cirrhosis, which increases a risk of liver cancer. Cancer cells have a consistent cytological feature of nucleolar hypertrophy, enlarg | Health and Human Services, Department of / National Institutes of Health | 5/22/2009 |
| UNIVERSITY OF KENTUCKY | $392,234 | Grant | Trans-NIH Recovery Act Research Support: Fetal Alcohol Spectrum Disorder describes a wide range of behaviors and deficits that can occur as a consequence of prenatal alcohol exposure. These effects can range from relatively subtle learning deficits to significant mental retardation. Various expl | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| UNIVERSITY OF KENTUCKY | $351,606 | Grant | Trans-NIH Recovery Act Research Support: It has been shown that peripheral clearance of amyloid beta peptides reduces amyloid beta peptide levels in the brain through what has been termed a 'sink effect'. We have exploited this 'sink effect' by showing that the peptidase neprilysin, when express | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $355,159 | Grant | Trans-NIH Recovery Act Research Support: Insomnia and sleep apnea (abnormal breathing patterns during sleep) are common in older adults and may each lead to increased risk of disease or death. Insomnia and sleep apnea may exist together in older adults in about 30% of cases and this combined sta | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $336,970 | Grant | Trans-NIH Recovery Act Research Support: The capacity of lipid molecules in cell membranes to separate into multiple liquid phases, forming so- called lipid rafts, has in the past decade been identified as an important physiological process. Lipid rafts are a control element in the cell membrane | Health and Human Services, Department of / National Institutes of Health | 4/29/2009 |
| HEALTH RESEARCH, INC. | $409,123 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Many members of the genus Flavivirus are significant human pathogens. The 5' end of flavivirus plus- sense RNA genome contains a type 1 cap (m7GpppAmG). We recently found a general mechanism that the flavivirus NS5 met | Health and Human Services, Department of / National Institutes of Health | 5/11/2009 |
| THE VANDERBILT UNIVERSITY | $426,355 | Grant | Trans-NIH Recovery Act Research Support: The gut mucosa represents a major entry point for many pathogens and is the target of a variety of inflammatory conditions, including the idiopathic inflammatory bowel diseases (IBD) ulcerative colitis and CrohnG??s disease. Emerging evidence suggests a c | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF WASHINGTON | $428,978 | Grant | Trans-NIH Recovery Act Research Support: Intravenous delivery of recombinant adenovirus (Ad) vectors for gene therapy is hampered by safety and efficacy problems. We have recently discovered a new pathway that is involved in unspecific sequestration and clearance of commonly used Ad5 and Ad B-gr | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $408,271 | Grant | Trans-NIH Recovery Act Research Support: This project is designed to further our knowledge of the use of molecular hydrogen by the enteric pathogen Salmonella typhimurium. Molecular hydrogen is produced within the host animal, and some pathogens such as Salmonella capitalize on its availability | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $403,750 | Grant | Trans-NIH Recovery Act Research Support: Francisella tularensis is a highly efficient zoonotic pathogen that is able to establish a virulent infection with 10 organisms or less. To accomplish this feat the bacterium must have devised efficient means of infecting its host, and effective ways of a | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| BROWN UNIVERSITY IN PROVIDENCE IN STATE OF RI AND PROVIDENCE PLANTATIONS | $419,435 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): In this collaborative program, we will develop an integrated Influenza Detection Microchip capable of performing identification of sequence-specific influenza subtypes. Our device accepts clinical specimens from mucosa | Health and Human Services, Department of / National Institutes of Health | 5/19/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $426,401 | Grant | Trans-NIH Recovery Act Research Support: Substantial interest in harnessing the immune system as a means of therapy for cancer has arisen from both animal and human subject studies. These studies have revealed the potential benefits of triggering specific immune components, including T lymphocyt | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| DUKE UNIVERSITY | $429,000 | Grant | Trans-NIH Recovery Act Research Support: This project will develop and apply methods to analyze functioning of a microbicide product vaginal epithelial coating layer - to inhibit transport of HIV virions from semen to tissue and enable microbicide molecules to disable virus. We will contribute t | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF IOWA, THE | $401,778 | Grant | Trans-NIH Recovery Act Research Support: According to the CDC, healthcare-associated infections affect about two million patients in American hospitals each year. Infections like influenza and MRSA routinely spread to and among hospitalized patients, often via healthcare workers. To better under | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| UNIVERSITY OF WASHINGTON | $429,000 | Grant | Trans-NIH Recovery Act Research Support: Microfluidics for malaria pathogenesis in AfricaSignificance: Malaria parasites infect about a billion individuals and cause up to 2 million deaths per year. A more complete understanding of the pathology caused by Plasmodium falciparum is needed, especi | Health and Human Services, Department of / National Institutes of Health | 7/23/2009 |
| THOMAS JEFFERSON UNIVERSITY | $396,801 | Grant | Trans-NIH Recovery Act Research Support: In the Americas, bats represent a major reservoir for rabies virus (RV) and most of the human rabies cases that were reported during the last twenty years in the US were caused by RV variants that circulate in bat species. Unlike the classical human rabie | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF WASHINGTON | $456,186 | Grant | Trans-NIH Recovery Act Research Support: One major obstacle for HIV vaccine development is the enormous genetic variability in strains between and within individuals. Several studies have proposed a universal HIV-1 vaccine that exclusively targets the highly conserved regions of the viral proteo | Health and Human Services, Department of / National Institutes of Health | 7/23/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $451,000 | Grant | Trans-NIH Recovery Act Research Support: The HIV-1 virion infectivity factor (Vif) is an essential regulatory protein required for HIV-1 replication in natural target cells such as CD4+ T-cells and macrophages. Recent studies from our group and others have demonstrated that Vif is a critical vir | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| SAN DIEGO STATE UNIVERSTIY FOUNDATION | $408,651 | Grant | Trans-NIH Recovery Act Research Support: In the present investigation we will use competitive peptide inhibitiors in an attempt to disrupt the association between ITK and SLP 76 and inhibit the activation of ITK in live cells. This presumably should create a condition that would mimic the situat | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| UNIVERSITY OF MASSACHUSETTS | $3,684,576 | Grant | Trans-NIH Recovery Act Research Support: The discovery of the Toll-Like Receptor Proteins (TLRs) and their importance in the regulation of host response to infection has led to a series of investigations related to the role of host proteins and cytokines in microbial pathogenesis. Recent work ha | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| UNIVERSITY OF TENNESSEE | $1,320,676 | Grant | Trans-NIH Recovery Act Research Support: The Consortium for Health Education, Economic Empowerment and Research (CHEER) NCMHD Exploratory Center of Excellence has as its primary mission to: engage in community-based collaborations to accomplish research and incorporate the role of community asse | Health and Human Services, Department of / National Institutes of Health | 9/19/2009 |
| THOMAS JEFFERSON UNIVERSITY | $772,500 | Grant | Trans-NIH Recovery Act Research Support: Accumulating evidence has indicated that human immunodeficiency virus type 1 (HIV-1) replication is regulated by cell- or virus-derived miRNAs. Recently, we have found that several cellular miRNAs are involved in establishing and maintaining HIV-1 latency | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| YALE UNIVERSITY | $761,988 | Grant | Trans-NIH Recovery Act Research Support: Tobacco use is mostly initiated during adolescence and we have few effective smoking cessation or prevention strategies for high school aged smokers. This project will develop and test an innovative high-school based intervention that will be designed to | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| CHILDREN'S HOSPITAL & RESEARCH CENTER | $791,150 | Grant | Trans-NIH Recovery Act Research Support: Red cell maturation depends on increased expression of proteins for iron uptake, transport, concentration, and heme synthesis to produce hemoglobin. Ferritin plays a key role in red cells and iron homeostasis: concentrating iron as a mineral and protectin | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| UNIVERSITY OF NEBRASKA | $742,500 | Grant | Trans-NIH Recovery Act Research Support: Recent evidence implicates that the oxidative stress plays a role in the etiology of Age-Related Cataract, and suggests that aged lens cells are prone to this damage due to reduced expression of antioxidants. Because ocular lens is constantly exposed to e | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF NEBRASKA | $280,500 | Grant | Trans-NIH Recovery Act Research Support: Retinal degenerations are a group of genetically heterogeneous disorders that can often be classified according to the type of pathology observed in rod and cone photoreceptors. These diseases affect one in every 4000 individuals and it is clear the sever | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF TENNESSEE | $1,289,403 | Grant | Trans-NIH Recovery Act Research Support: Individuals born small for gestational age face severe health problems as children and increased risks as adults of essential hypertension, cardiovascular disease, type 2 diabetes and pregnancy-related hypertension and diabetes. There are two types of gen | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| YALE UNIVERSITY | $827,500 | Grant | Trans-NIH Recovery Act Research Support: Understanding the effects of VEGF augmentation in the developing lung as a method of lung maturation, and defining the contributions of the Nitric Oxide pathway in this process, can pave the way for appropriate therapeutic interventions in the human disea | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| CHILDREN'S HOSPITAL & RESEARCH CENTER | $812,000 | Grant | Trans-NIH Recovery Act Research Support: The plasma level of high density lipoprotein (HDL) is a primary indicator of clinical risk for the onset of atherosclerosis. This property is ascribed to the HDLG??s ability to facilitate reverse cholesterol transport (RCT), the major means of removing ex | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| CHILDREN'S HOSPITAL & RESEARCH CENTER | $1,330,436 | Grant | Trans-NIH Recovery Act Research Support: The proposed research program will focus on detecting genetic contributions to the two most common conotruncal heart defects, tetralogy of Fallot and d-transposition of the great arteries. The recent development of array comparative genomic hybridization | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $1,319,429 | Grant | Trans-NIH Recovery Act Research Support: NOVEL INTERACTIONS OF SLO1 CHANNEL AND THROMBOXANE A2 RECEPTOR IN BLOOD VESSELS . The overall objectives are: 1) To unravel the molecular mechanism(s) of Slo1 channel inhibition by agonist (U46619)-activated Thromboxane A2 receptor and 2) Define the role | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| YALE UNIVERSITY | $165,500 | Grant | Trans-NIH Recovery Act Research Support: The results of this project will provide crucial information that will improve the effectiveness of Lyme Disease prevention methods directed towards wildlife reservoirs, such as vaccinating wildlife. This project provides a method to identify the wildlife | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| YALE UNIVERSITY | $419,520 | Grant | Trans-NIH Recovery Act Research Support: An individual's sensitivity to aversive drug effects is likely to be important not only in the manifestations and course of drug dependence (e.g., in experienced users) but also in the predisposition and/or progression to addiction (e.g., in inexperienced | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| YALE UNIVERSITY | $496,500 | Grant | Trans-NIH Recovery Act Research Support: These studies will allow us to better understand the molecular basis for individual differences in the response to progesterone in cocaine dependent men and women. Better understanding of these differences will allow us to identify those individuals (both | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF MASSACHUSETTS | $438,448 | Grant | Trans-NIH Recovery Act Research Support: the goal of the proposed study is to adapt and test the evidence-based collaborative care model (CCM) for homeless women with alcohol use disorders (AUD), including the continuum of risky drinking, abuse and dependence, in a large Health Care for the Home | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $347,272 | Grant | Trans-NIH Recovery Act Research Support: 'AMYLOID PLAQUE AND TANGLE IMAGING IN ALZHEIMER'S DISEASE AND DOWN SYNDROME' Down syndrome is a model for the study of Alzheimer's disease because almost 100% of middle-aged individuals with this condition show a specific pathogenic process that follows | Health and Human Services, Department of / National Institutes of Health | 5/18/2009 |
| SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | $430,705 | Grant | Trans-NIH Recovery Act Research Support: MOLECULAR ALGORITHMICS FOR PHARMACOLOGICAL INTERVENTIONS This proposal originates from discussions between scientists from different scientific fields: Drosophila aging physiology, information theory, statistics, bioengineering and systems biology. Biolog | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY OF TENNESSEE | $399,800 | Grant | Trans-NIH Recovery Act Research Support: The study aims to serve as a proof of concept model of individualized medicine in Infectious diseases that will also advance our understanding of innate immunity and chlamydial pathogenesis. The individual differences in susceptibility to various infectio | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| YALE UNIVERSITY | $455,125 | Grant | Trans-NIH Recovery Act Research Support: PLUNC is a recently discovered protein that is present in high concentrations in the secretions that bathe the respiratory tract. PLUNC is present in all mammals, yet its functions have not been fully elucidated. Our early studies show that PLUNC regulate | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | $977,102 | Grant | Trans-NIH Recovery Act Research Support: Calcification of the medial layer of arteries is common in patients with chronic kidney disease (CKD) and correlates with cardiovascular events and death. Research in our laboratories has demonstrated that vascular calcification is normally inhibited by e | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF WASHINGTON | $698,108 | Grant | Trans-NIH Recovery Act Research Support: The primary goal of this project is to evaluate the role of FDG PET and its ability to predict early treatment response and drug resistance in advanced epithelial ovarian cancer (AOC). A vast majority of ovarian cancer patients present with advanced stag | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $372,680 | Grant | Trans-NIH Recovery Act Research Support: Epigenetic silencing plays a major role in cancer formation because it leads to aberrant inactivation of tumor suppressor genes. Therefore, a fundamental goal for cancer prevention is to inhibit aberrant silencing in somatic cells. Diet provides a potenti | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $381,150 | Grant | Trans-NIH Recovery Act Research Support: Head and neck cancers (HNC) are the sixth most common form of cancer worldwide, with over 500,000 new cases diagnosed annually. Although advances in surgery, and combined of radio and chemotherapies, have decreased morbidity, the survival rate at 5 years | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF TENNESSEE | $427,955 | Grant | Trans-NIH Recovery Act Research Support: Drugs targeting the HIV virus transcriptase or protease are used in highly active antiretroviral therapy (HAART) cocktails that have prolonged the lives of AIDS patients. Unfortunately, these drugs are associated with severe toxicities, unable to control | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| YALE UNIVERSITY | $443,892 | Grant | Trans-NIH Recovery Act Research Support: Morbidity and mortality associated with severe infections caused by Staphylococcus aureus present a staggering burden on the healthcare in the United States. The increasing antibiotic resistance of S. aureus limits effectiveness of available antibiotic th | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| UNIVERSITY OF TENNESSEE | $845,643 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area: (01) 'Behavior, Behavior Change, and Prevention' and Specific Challenge Topic: 01-AR-101 'Integrating Behavioral and Biomedical Research Approaches in Arthritis and Musculoskeletal Diseases' Patients with r | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| YALE UNIVERSITY | $985,031 | Grant | Trans-NIH Recovery Act Research Support: Our Broad Challenge is to develop enabling technologies for the prevention and treatment of diseases affecting the bladder. The Proof of Concept that we are testing is that intravesical instillation of small interference RNA (siRNA) packaged in biodegrada | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | $955,000 | Grant | Trans-NIH Recovery Act Research Support: Our overall goal is to create a 3-dimensional tissue culture model amenable to high throughput screening (HTS), and perform a screen on large libraries of chemical agents. We initially carried out proof-of-concept screens with characterized and FDA-approv | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| EMORY UNIVERSITY | $995,992 | Grant | Trans-NIH Recovery Act Research Support: Project Title: Economic Consequences of Advanced Testing for Subclinical Cardiovascular Disease The current application is written as a response to requests for applications in the area of NIH Challenge Grants in Health and Science Research (RC1) in the B | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| MISSISSIPPI STATE UNIVERSITY | $386,988 | Grant | Trans-NIH Recovery Act Research Support: Placental regulatory T cells (Tregs) are centrally-important in the maintenance of pregnancy because their immunosuppressive function allows maternal immune tolerance to the semi-allogeneic fetus. HIV infection may result in increased rates of miscarriage | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| UNIVERSITY OF CONNECTICUT | $377,708 | Grant | Trans-NIH Recovery Act Research Support: The central goal of our work is to use embryonic stem (ES) cells as a source from which to derive therapeutically relevant skeletal progenitor cells to treat conditions associated with bone and cartilage damage. The field of cell based | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| RUSH UNIVERSITY MEDICAL CENTER | $412,487 | Grant | Trans-NIH Recovery Act Research Support: The overall purpose of the award to study the effectiveness of combining two known stimulators of bone healing - Bone Morphogenetic Protein 2 and Low Intensity Pulsed Ultrasound - in a clinical relevant model of orthopedic trauma. While either of these tr | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF CHICAGO, THE | $394,396 | Grant | Trans-NIH Recovery Act Research Support: This proposal builds upon work suggesting that the herbal extract Scutellaria baicalensis (SbE) and its major component baicalein may simulate many important components of cardiac preconditioning (PC), i.e. trigger transient mitochondrial oxidant signalin | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| SAINT LOUIS UNIVERSITY | $842,672 | Grant | Trans-NIH Recovery Act Research Support: There are no effective treatments for hepatic fibrosis. There+???s an urgent need to develop therapeutic agents that delay/reverse hepatic fibrosis. We believe that PEG-TGF-B peptantagonist should be an ideal candidate for treating human liver fibrosis. | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $998,210 | Grant | Trans-NIH Recovery Act Research Support: Interpersonal behavior affects individuals' emotions, arousal, stress, and facilitated or impairs social support, intimacy, and relational satisfaction. This project will deliver new methods and models that allow for more specific articulation and linking | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| THOMAS JEFFERSON UNIVERSITY | $997,110 | Grant | Trans-NIH Recovery Act Research Support: This application addresses the broad Challenge Area (05) Comparative Effectiveness Research and specific Challenge Topic, 05-MH-102*: Cost Effectiveness of Mental Health Interventions. We propose a two year initiative to add a cost and outcome component | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | $1,836,114 | Grant | Trans-NIH Recovery Act Research Support: The ubiquitin system of protein modification permeates every field in biology and is intimately linked to the most prevalent human diseases, including cancer, neurodegeneration, inflammation, and viral infections. With ~30 E2s and an estimated several hun | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF ARKANSAS SYSTEM | $1,074,763 | Grant | Trans-NIH Recovery Act Research Support: This proposal describes a stable isotope analytical core to support world-wide research in human metabolic studies. The core offers routine and specialized sample analysis on a minimal fee-for-service basis. In addition, it will provide assistance in meth | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF MASSACHUSETTS | $3,608,339 | Grant | Trans-NIH Recovery Act Research Support: Full Human Genome Sequencing in ALS - The causes of most neurodegenerative disorders (ALS, Alzheimer and Parkinson disease) are poorly understood, despite remarkable advances in delineating the molecular pathology in the rare forms of these diseases that | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $453,372 | Grant | Trans-NIH Recovery Act Research Support: This proposal uses knowledge gained from extensive research into the activity of the influenza virus NS1 protein, to devise a strategy that will lead to the discovery of new influenza virus drug candidates. It is widely acknowledged that the consequences | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| NEW YORK UNIVERSITY (INC) | $464,938 | Grant | Trans-NIH Recovery Act Research Support: Trichomoniasis is the most common non-viral STD, estimated to cause ~174 million infections world-wide each year. The Trichomonas vaginalis parasite resides in the urogenital tract of both sexes and can cause vaginitis in women and urethritis and prostati | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $781,494 | Grant | Trans-NIH Recovery Act Research Support: This application proposes to develop two novel prophylactic and therapeutic non-viral gene transfer strategies that target pulmonary cells in vivo employing nanotechnology. The lung is especially well suited for these treatment strategies as direct contac | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF ROCHESTER | $423,396 | Grant | Trans-NIH Recovery Act Research Support: Candida albicans is an important opportunistic fungal pathogen that causes both mucosal and invasive disease in immunocompromised patients. Nearly all HIV/AIDS patients will develop oropharyngeal (OPC) or esophageal candidiasis during their lifetime. Beca | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $269,726 | Grant | Trans-NIH Recovery Act Research Support: Real time quantitative multiplex analysis of cell-cell interactions, Award number: R21CA128718-01-A2, The objective of this award is the development of a platform for the parallel and time dependent analysis of cell-cell communication. The device will pro | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $382,368 | Grant | Trans-NIH Recovery Act Research Support: Proteins play major roles as biological effectors and diagnostic markers. One level of its complexity is due to the post-translational modifications that cannot be detected at the genome level, which makes it desirable to measure proteins directly. Recent | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $393,323 | Grant | Trans-NIH Recovery Act Research Support: Historically, the aryl hydrocarbon receptor (AhR) has been studied for its transcriptional regulation of genes encoding cytochrome P450 enzymes, which metabolize environmental and endogenous substrates into toxic and mutagenic intermediates. Accumulating | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| PURDUE UNIVERSITY | $369,050 | Grant | Trans-NIH Recovery Act Research Support: Chronic Hepatitis B virus (HBV) infection is linked to hepatocellular carcinoma (HCC). The HBV X protein (pX) is implicated in HCC pathogenesis by an unknown mechanism. The long term goals of this study are to determine how pX initiates hepatocyte transfo | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| THE TRUSTEES OF DAVIDSON COLLEGE | $370,064 | Grant | Trans-NIH Recovery Act Research Support: The proposed research study responds to an unmet need for the successful implementation and dissemination of evidence-based tobacco cessation care for the uninsured. The overall intent of this research is to ultimately close the gap between research disco | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $641,559 | Grant | Trans-NIH Recovery Act Research Support: Attaining control over specific neural processes can enable people to influence associated perceptions, behaviors, and cognitions, with potential clinical application to a range of brain- based disorders, including substance abuse (SA). Using real-time fM | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| BROWN UNIVERSITY IN PROVIDENCE IN STATE OF RI AND PROVIDENCE PLANTATIONS | $444,750 | Grant | Trans-NIH Recovery Act Research Support: Schizophrenia is associated with an unusually high rate of cigarette smoking. Smokers with schizophrenia have low quit rates, even when they are motivated to quit and enroll in highly-supportive treatments. The overall aim of this research program is to l | Health and Human Services, Department of / National Institutes of Health | 5/18/2009 |
| UNIVERISTY OF MISSISSIPPI MEDICAL CENTER | $296,000 | Grant | Trans-NIH Recovery Act Research Support: Imposing delay between a behavior and its reinforcer weakens the effectiveness of that reinforcer and decreases its subjective value, a phenomenon referred to as temporal discounting. There is a well-established mathematical model, the hyperbolic discoun | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $467,500 | Grant | Trans-NIH Recovery Act Research Support: The mammalian circadian timing system contains both a light- and food-entrainable oscillator, located in the suprachiasmatic (SCN) and dorsomedial (DMH) hypothalamic nucleus, respectively. Additional studies have suggested the presence of a Methamphetamin | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $357,207 | Grant | Trans-NIH Recovery Act Research Support: Language acquisition, performance in school, and social interactions all require the ability to compensate for the enormous amount of variability in the speech signal introduced by differences across talkers in native language, dialect, age, gender, and e | Health and Human Services, Department of / National Institutes of Health | 5/01/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $489,249 | Grant | Trans-NIH Recovery Act Research Support: Bisphosphonates are the most common treatment for osteoporosis. In the last few years, increasing reports of osteonecrosis of the jaw (ONJ) have raised considerable concerns regarding the long-term safety of these agents. The case reports have created con | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $402,625 | Grant | Trans-NIH Recovery Act Research Support: This R21 2-year grant will test our hypothesis that the urine proteome of IgAN patients contains disease-specific biomarkers. We aim to develop a non-invasive procedure for screening and monitoring patients with IgA nephropathy by identifying urinary poly | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $427,100 | Grant | Trans-NIH Recovery Act Research Support: Chronic renal allograft survival is poorer in African Americans than Caucasians which may be due to medication non-adherence, racial differences in immunosuppressive pharmacokinetics, genomic factors, increased immunoreactivity, and racial variation in im | Health and Human Services, Department of / National Institutes of Health | 6/23/2009 |
| LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER | $408,951 | Grant | Trans-NIH Recovery Act Research Support: The proportion of individuals with advanced chronic kidney disease who undergo chronic peritoneal dialysis (CPD) treatment, currently <8% of the 400,000 dialysis patients in the USA, has been declining steadily in the past several years. However, the tota | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $431,750 | Grant | Trans-NIH Recovery Act Research Support: Hypertension is a major cause of morbidity and mortality in the United States, especially in the African American population where the prevalence, consequences, and severity of hypertension are at their highest; making strategies for its control and treat | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF FLORIDA | $402,875 | Grant | Trans-NIH Recovery Act Research Support: This project is to evaluate the roles of beta cell antigens presented by dendritic cells in the immunotherapy for type 1 diabetes (T1D), T1D mouse model NOD mice are used in the whole project. The objective is to develop optimal approaches for DC-based T1 | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| DREXEL UNIVERSITY | $422,000 | Grant | Trans-NIH Recovery Act Research Support: This study aims to compare the effectiveness of traditional behavioral therapy (based on Brownell's LEARN program for weight management, 2000) with acceptance-based therapy (based on the behavioral and nutritional components of LEARN) for weight loss. Bro | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| GEORGIA HEALTH SCIENCES UNIVERSITY RESEARCH INSTITUTE, INC. | $404,250 | Grant | Trans-NIH Recovery Act Research Support: : The long-term aim of to limit disease in man. Toward this goal, we will take advantage of: the restricted nature of 13(IV) collagen (13(IV) and its available epitopes with the kidney; the availability of a unique panel of human monoclonal antibodies (mA | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE, INC. | $336,500 | Grant | Trans-NIH Recovery Act Research Support: The purpose is to delevop and characterize an in vitro system for measurement of dudenal bicarbonate secretion. | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| ST LUKE'S-ROOSEVELT HOSPITAL CENTER | $443,331 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Exploring Specific Metabolic Rates of Major Cell Categories in Adiposity-Diverse Adults ABSTRACT Obesity is a significant health problem in the USA. Previous studies observed that obese adults have greater resting ener | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $228,683 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this protocol is to investigate the central nervous system dysfunction that is associated with chronic pelvic pain and also a possible novel treatment using a neuromodulatory tool - transcranial direct current stimulation (tDCS) - for this | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $408,375 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): While erythropoietin (Epo) is commonly used to treat anemia in patients with cancer and kidney disease, recent studies have raised major safety concerns. There is great interest in developing new strategies to modulate | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $503,744 | Grant | Trans-NIH Recovery Act Research Support: Childhood obesity is a formidable health threat, with 1 in 3 American children overweight or obese. Innovative approaches are needed to reverse this epidemic and prevent related complications such as type 2 diabetes and high blood pressure. Deficiency of | Health and Human Services, Department of / National Institutes of Health | 7/19/2009 |
| UNIVERSITY OF PITTSBURGH THE | $409,026 | Grant | Trans-NIH Recovery Act Research Support: This is a pilot study to establish a profile of oxidative stress among participants in the Epidemiology of Diabetes Complications (EDC) study to assess whether the degree to which an individual is able to respond to oxidative stress modifies the risk of d | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL | $396,000 | Grant | Trans-NIH Recovery Act Research Support: Good glycemic control clearly prevents diabetic complications and decreases the risk of heart disease in patients with type 1 diabetes. However, it is unclear how acute and short-term variations affect precursor to diabetic complications. For instance the | Health and Human Services, Department of / National Institutes of Health | 5/11/2009 |
| PALO ALTO INSTITUTE FOR RESEARCH AND EDUCATION, INC. | $405,731 | Grant | Trans-NIH Recovery Act Research Support: Conventional dialysis provides limited clearance of organic solutes that accumulate when the kidneys fail. Numerous studies are therefore examining the effects of increasing dialysis frequency and duration. An alternate approach would be to reduce solut | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY OF MARYLAND | $412,500 | Grant | Trans-NIH Recovery Act Research Support: One-fifth of the genome codes for secretory proteins; a small subset of these proteins represent peptide hormone signaling molecules. This proposal addresses the identification of novel secretory molecules involved in the control of metabolic function. Si | Health and Human Services, Department of / National Institutes of Health | 5/26/2009 |
| HUGO W. MOSER RESEARCH INSTITUTE AT KENNEDY KRIEGER, INC. | $442,750 | Grant | Trans-NIH Recovery Act Research Support: Relationship of MRI to ASIA Impairment Scale in Chronic Spinal Cord Injury. The objective of this investigation is two-fold: 1) to add to the classification value of the American Spinal Injury Association (ASIA) Impairment Scale by establishing imaging c | Health and Human Services, Department of / National Institutes of Health | 4/30/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $411,210 | Grant | Trans-NIH Recovery Act Research Support: Role of the Aryl hydrocarbon receptor (AhR) and RelB during the initiation of dendritic cell differentiation. The present study focuses on a new mechanism of cross talk between AhR and the NF-?B member RelB (alternative AhR/RelB pathway), which suggests a | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL | $408,692 | Grant | Trans-NIH Recovery Act Research Support: Vascular toxicities of environmental tobacco particulates in children: The objective of this study is to define the relationship between environmental tobacco smoke, obesity, and blood vessel function in children. A result of theis study will have signi | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF HOUSTON SYSTEM | $412,500 | Grant | Trans-NIH Recovery Act Research Support: Bacterial keratitis is a major cause of ocular surface morbidity that often leads to permanently compromised visual function, somethings to an extent that necessitates corneal transplantation to resture adequate vision. Often the bacterial strains that c | Health and Human Services, Department of / National Institutes of Health | 8/19/2009 |
| THE GEORGE WASHINGTON UNIVERSITY | $371,049 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION: This proposal focuses on the application of therapeutic ultrasound in improving ocular drug delivery. The proposed research will address an important clinical problem since it is often difficult to achieve therapeutic levels of drugs at the t | Health and Human Services, Department of / National Institutes of Health | 8/19/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $415,250 | Grant | Trans-NIH Recovery Act Research Support: Smad3 plays a central role in the TGF?-mediated fibrosis with characteristic inflammation, proliferation and transformation of fibroblasts and epithelial-to- mesenchymal transition. Gene therapy and small chemicals targeting Smad3 signaling have shown gre | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| THOMAS JEFFERSON UNIVERSITY | $421,333 | Grant | Trans-NIH Recovery Act Research Support: G8pos skeletal muscle stem/progenitor cells may provide the source of ?-smooth muscle actin positive myofibroblasts detected in lens fibrotic diseases. We hypothesize that disruption of the G8pos epiblast-skeletal muscle stem cell niche, such that could | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE | $396,000 | Grant | Trans-NIH Recovery Act Research Support: Fertility and Oral Contraceptive Use Study (FOCUS) Oral contraceptives (OCs) are the most popular reversible method of contraception in the US. Although most women using OCs experience reliable protection against pregnancy, nearly half of the 3 million | Health and Human Services, Department of / National Institutes of Health | 4/27/2009 |
| RHODE ISLAND HOSPITAL | $410,730 | Grant | Trans-NIH Recovery Act Research Support: Inflammatory Bowel Diseases (IBD) are chronic and unpredictable disorders of the gastrointestinal tract associated with significant morbidity, intrusive medical and surgical interventions, and disability. Incidence of IBD, especially among children and ad | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| TEXAS A & M UNIVERSITY SYSTEM HEALTH SCIENCE CENTER RESEARCH | $237,373 | Grant | Trans-NIH Recovery Act Research Support: NTDs are a group of common, structural malformation that is associated with excess morbidity and mortality. A specific etiologic agent(s) cannot be identified in the majority of individuals with NTDs, and in this group of patients the condition is believe | Health and Human Services, Department of / National Institutes of Health | 4/30/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $423,500 | Grant | Trans-NIH Recovery Act Research Support: This study will provide current data designed to develop and test a targeted sexual health intervention among bisexual men, a high risk population for HIV infection and transmission. Scientific outcomes will add to the knowledge base that is lacking evide | Health and Human Services, Department of / National Institutes of Health | 5/11/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $424,873 | Grant | Trans-NIH Recovery Act Research Support: Obesity is a burgeoning public health problem that is associated with an adverse metabolic profile and higher levels of morbidity and mortality from multiple causes. Current methods for assessing obesity focus on either nonspecific measures of overall bod | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| CEDARS-SINAI MEDICAL CENTER | $418,750 | Grant | Trans-NIH Recovery Act Research Support: An ideal therapy for genetic blood diseases would correct defective genes in the patient's own hematopoietic stem cells (HSC). Homologous recombination (HR) can, in principle, achieve this; however, its practicality is restricted by the scarcity of HSC an | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $446,875 | Grant | Trans-NIH Recovery Act Research Support: This two-year proposal describes the development of functional lymphatic networks and their integration into artificial dermal constructs in vitro. While many methods have been developed to form microvascular networks suitable for perfusion of engineered | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $438,412 | Grant | Trans-NIH Recovery Act Research Support: In August 2011, the second manuscript for this project was accepted for publication in the Journal of Autoimmunity. The article entitled G?Antigenic Challenge in the Etiology of Autoimmune Disease in WomenG? will be published in a special issue regarding | Health and Human Services, Department of / National Institutes of Health | 5/18/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $486,375 | Grant | Trans-NIH Recovery Act Research Support: A variety of novel nanomaterials have recently been developed with primary in vivo distribution to macrophages and macrophage subtypes. These materials have been used for the diagnosis of diseases where macrophages play a critical role in pathogenesis. Fo | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $372,680 | Grant | Trans-NIH Recovery Act Research Support: The tetraspan protein EMP2 is a novel biomarker for endometrial cancer prognosis and survival. Specificially, EMP2 expression is upregulated in a significant subset of endometrial hyperplasia and cancer patients. We therefore reasoned that EMP2 may be a | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $372,680 | Grant | Trans-NIH Recovery Act Research Support: Tumor metastasis represents the major cause of morbidity and mortality in breast cancer. The studies described here investigate the molecular mechanisms by which biobehavioral factors might facilitate breast cancer metastasis to distant target organs in | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF TENNESSEE | $287,064 | Grant | Trans-NIH Recovery Act Research Support: Taste has profound effects on smoking behavior. Most importantly, smokers of flavored cigarette have higher odds for relapse. Gustatory and other visceral sensory information are processed and integrated in the insular cortex. Damaging of insular cortex i | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $955,928 | Grant | Trans-NIH Recovery Act Research Support: TITLE: 'USING PERCEPTUAL AND ADAPTIVE LEARNING TO ADVANCE CHEMISTRY EDUCATION.' Recently developed innovations in perceptual and adaptive learning technologies will be applied to chemistry learning in community college settings and rigorously evaluated f | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| YALE UNIVERSITY | $999,475 | Grant | Trans-NIH Recovery Act Research Support: We described rickets in children in our inner city area (over 80% minorities) with either low or normal circulating 25-hydroxyvitamin D (25-OHD) levels, and have found that vitamin D deficiency (circulating 25-OHD less than 20 ng/ml) occurs in 13% of over | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $970,660 | Grant | Trans-NIH Recovery Act Research Support: Title: Self-monitoring using GPS- and accelerometer-equipped smartphones Description: We are evaluating the validity and reliability of self-monitoring diet, stress, and exercise (three key risk factors for cardiovascular disease) using a mobile phone. | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $822,395 | Grant | Trans-NIH Recovery Act Research Support: Title:ANTIBODIES TO DEFINE MOLECULAR MECHANISMS OF HYPERTRIGLYCERIDEMIA DESCRIPTION: This application addresses Challenge Area (06): Enabling Technologies and Specific Challenge Topic 06- HL-102, which is to develop high affinity/high specificity targete | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF PITTSBURGH THE | $411,731 | Grant | Trans-NIH Recovery Act Research Support: Advances in medical monitoring have failed to improve outcomes and significantly impact medical decision making by bedside clinicians, particularly in the acute care setting. Computerized decision support technologies based on quantitative, mechanistic m | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| GEORGIA HEALTH SCIENCES UNIVERSITY RESEARCH INSTITUTE, INC. | $404,250 | Grant | Trans-NIH Recovery Act Research Support: The long-term objective of the application is to understand how emotional experiences alter memory acquisition and consolidation processes in the forebrain. The PI was instrumental in developing recent technological advances that allow powerful within-ani | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $413,430 | Grant | Trans-NIH Recovery Act Research Support: Disturbances in maternal care have been associated with impairments in affective and cognitive development of the offspring. In humans, there is growing evidence that postpartum mood disorders have a negative impact on the mother-child relationship, and t | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| SAN FRANCISCO STATE UNIVERSITY | $431,363 | Grant | Trans-NIH Recovery Act Research Support: To support the study to identify psychological and behavioral factors that help prevent gay fathers from HIV risk, substance abuse, and psychological distress as they navigate the myriad life-changing situations faced as parents. | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $415,762 | Grant | Trans-NIH Recovery Act Research Support: Description of the ARRA-funded project: The overarching goal of this proposal is to evaluate a potentially unifying psychobiological mechanism underlying social deficits and restricted repetitive behaviors (RRBs) in autism. The potential ultimate impact | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $422,255 | Grant | Trans-NIH Recovery Act Research Support: Ample evidence suggests that a dramatic decrease in mitochondrial Ca2+ retention may contribute to cell death associated with stroke, excitotoxicity, ischemia and reperfusion, and neurodegenerative diseases. Mitochondria from all known tissues can accumul | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $380,541 | Grant | Trans-NIH Recovery Act Research Support: Myostatin (MSTN) is a secreted protein that normally acts to suppress muscle growth. Mice genetically engineered to lack MSTN activity have dramatic increases in muscle mass as a result of a combination of muscle fiber hypertrophy and increased fiber numb | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| FLORIDA ATLANTIC UNIVERSITY | $391,875 | Grant | Trans-NIH Recovery Act Research Support: Award Title G?? Efficacious Screening of Peptidic Natural Products using Drosophila. Peptidic natural products are powerful neuropharmacological agents that can be used for a wide variety of applications. The venom of cone snails, a genus of predatory m | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| SANFORD RESEARCH / USD | $451,880 | Grant | Trans-NIH Recovery Act Research Support: The juvenile onset form of Batten disease (Juvenile Neuronal Ceroid Lipofuscinosis, JNCL), a fatal neurodegenerative disorder, results from mutations in the CLN3 gene. No specific treatment is currently available that could halt or slow the progression of | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $408,531 | Grant | Trans-NIH Recovery Act Research Support: After injury, unlike the axons of the central nervous system where the regeneration process is poor or absent, axons of the peripheral nervous system are able to regenerate, though inefficiently. Uncovering the molecular mechanisms behind axon regeneratio | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $540,654 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): We propose to conduct a first-ever comprehensive quantitative investigation of motor function in autism using simultaneous brain and movement imaging. A novel system developed by Co- Investigator Makeig and his colleag | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF MISSOURI SYSTEM | $409,050 | Grant | Trans-NIH Recovery Act Research Support: Pupillary light reflex (PLR) is a simple objective measure of neurological functions. Our preliminary study has revealed that individuals with autism show significantly longer constriction latencies and smaller constriction amplitudes. The proposed study | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF CALIFORNIA, SANTA CRUZ | $441,323 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Nanopores have shown great promise for DNA sequencing, and more recently as instruments for probing interactions between DNA and DNA-binding enzymes. The broad aim of the proposed research is to develop a nanopore-base | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| THE JACKSON LABORATORY | $494,175 | Grant | Trans-NIH Recovery Act Research Support: The mouse is an invaluable tool for modeling human disease. The tremendous power of the mouse is due in part to our ability to manipulate its genome in a precise manner, and our toolbox to perform these tasks is rapidly expanding. As part of The Jackson L | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| UNIVERSITY OF ROCHESTER | $3,120 | Grant | Trans-NIH Recovery Act Research Support: The Neuronal Ceroid Lipofuscinoses (NCL) is probably the most frequent group of progressive inherited neurodegenerative diseases with childhood onset. They can start at all ages and progression is characterized by one or more of the following symptoms: vi | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO | $1,030,928 | Grant | Trans-NIH Recovery Act Research Support: The Physical Activity Partnership for Girls seeks to build a strong community-academic partnership in order to investigate community priorities and needs for physical activity promotion among Latino adolescent girls (age 11-14 years) in Westside San Anton | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO | $923,886 | Grant | Trans-NIH Recovery Act Research Support: Bipolar disorder is a severe debilitating mental illness affecting over three and half million Americans. This illness crosses all gender and ethnic boundaries to cause extensive morbidly and mortality. With this tremendous burden on the patients, their f | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $535,928 | Grant | Trans-NIH Recovery Act Research Support: As part of public health efforts to curtail drug use and associated behaviors, secondary students must understand that addiction is a brain disease that results from drug-induced changes in the cellular processes mediating learning in the brain. The most | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| THOMAS JEFFERSON UNIVERSITY | $386,250 | Grant | Trans-NIH Recovery Act Research Support: The goal of these studies is to determine the mechanisms utilized by mouse and human neutrophils to control helminth infections. Previous studies have demonstrated that neutrophils are required for killing larval Strongyloides stercoralis in na+?ve and im | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| NATIONAL JEWISH HEALTH | $771,842 | Grant | Trans-NIH Recovery Act Research Support: The importance of T cells in the pathogenesis of asthma and other allergic diseases is undisputed. The extend of the T cell respose is tightly controlled by a variety of homeostatic mechanisms. T regulatory cells (Tregs) represent a major homeostatic me | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| WAKE FOREST UNIVERSITY | $370,000 | Grant | Trans-NIH Recovery Act Research Support: Reprogrammed expression of sets of inflammatory genes occurs during severe systemic inflammation (SSI). The gene silencing component of SSI reprogramming represses transcription of acute proinflammatory genes like TNF? and IL-1? to generate clinically rel | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $499,329 | Grant | Trans-NIH Recovery Act Research Support: M. tuberculosis (Mtb) has caused a global health emergency. Yet little new chemotherapy against Mtb has emerged in decades. This application aims to target a pathway in the pathogen that is not essential for the pathogen to survive in vitro but is essenti | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| HEALTH RESEARCH, INC. | $915,057 | Grant | Trans-NIH Recovery Act Research Support: The objective of this work is to determine how a Mycobacterial secretion apparatus called ESX-1 plays critical roles in important, but apparently disparate, molecular processes: conjugal DNA transfer and virulence. The proposed studies will elucidate the | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| NEW YORK UNIVERSITY (INC) | $406,961 | Grant | Trans-NIH Recovery Act Research Support: In a region of the world like West-Central Africa where multiple HIV-1 groups and subtypes co-circulate, the rate of dual infection -the concomitant or sequential infection with two or more geneticallly distinct HIV-1 strains- is frequent and recombinant | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $287,414 | Grant | Trans-NIH Recovery Act Research Support: This proposal outlines a comprehensive plan to genetically dissect the fatty acid metabolism of the human pathogen Toxoplasma gondii. T. gondii infection is widespread in the U.S. (22% of the population is chronically infected) and while usually benign ca | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $473,959 | Grant | Trans-NIH Recovery Act Research Support: A one-year NIH R56 (Bridge Award) grant to Dr. Henry Murray to support his continued laboratory research in the treatment of leishmaniasis, a parasitic infection. Expected outcome are: (a) the generation of new scientific results in experimentally infect | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF ARIZONA | $150,000 | Grant | Trans-NIH Recovery Act Research Support: The kidney and liver actively secrete many drugs from the body, and unwanted drug-drug interactions at the sites of secretion in these organs are a source of substantial morbidity and mortality. The rate-limiting step in the secretion of cationic drugs by | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| CORNELL UNIVERSITY, INC | $192,500 | Grant | Trans-NIH Recovery Act Research Support: The mTOR (mammalian target of rapamycin) and GCN2 [eukaryotic initiation factor 2 alpha (eIF2?) kinase 4] pathways play critical roles in integrating the organismG??s response to insulin, growth factors, energy status, and nutrient availability, and both | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UMDNJ-ROBERT WOOD JOHNSON MEDICAL SCHOOL | $195,000 | Grant | Trans-NIH Recovery Act Research Support: Despite extensive evidence implicating excess circulating non-esterified fatty acids (NEFA) in the induction of systemic insulin resistance, the mechanisms underlying elevated plasma NEFA levels remain unclear. Adipose tissue is the largest NEFA depot. T | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $798,470 | Grant | Trans-NIH Recovery Act Research Support: This innovative translational research endeavor will employ an established cue reactivity/exposure methodology to assess the therapeutic potential of an untested and potentially promising adjunctive pharmacotherapy for one of the most prevalent and intrac | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $484,872 | Grant | Trans-NIH Recovery Act Research Support: Genome wide association studies (GWAS) are typically carried out to uncoverpotential correlations between SNP genotypes and disease phenotypes. Often,cancer or neoplastic conditions have been the subject of these studies, and theyhave provided useful insi | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $998,992 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Are (06) Enabling Technologies and Specific Challenge Topic 06-CA-106 Data integration and visualization methods and tools. Prostate cancer is a highly prevalent disease in older men of the Western world, whose i | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $999,998 | Grant | Trans-NIH Recovery Act Research Support: We will perform deep sequencing of small regulatory RNAs expressed in the lymphoma biopsies from 250 patients with diffuse large Bcell lymphoma (DlBCl) and in lymph node biopsies from SO healthy donors, aiming to identify small regulatory RNAs with diagon | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE | $998,306 | Grant | Trans-NIH Recovery Act Research Support: Challenge Grant 1RC1DA028173 G?Adolescent Brains, Nicotine and Endogenous PrototoxinsG? is a new, multidisciplinary project that involves 5 neuroscientists from UVM in the areas of animal behavior, human cognition, and molecular cell biology together wit | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| IMMUNE DISEASE INSTITUTE, INC. | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: The methylation status of DNA influences many biological processes during mammalian development, including retrotransposon silencing, X-inactivation and asymmetric expression of parentally imprinted genes. In mammalian cells, DNA methylation occurs almos | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $558,471 | Grant | Trans-NIH Recovery Act Research Support: Understanding the neural mechanisms of tinnitus. The grant supports personnel and equipment needed to carry out an investigation into the neural activity in the brain that may underly tinnitus. Tinnitus is a phantom sound percept that occurs in many older | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC. | $606,669 | Grant | Trans-NIH Recovery Act Research Support: Networking of Brain activity in People with Tinnitus The proposed work will investigate a completely new brain mechanism for tinnitus directly in people. This mechanism - abnormal coordination, or coupling, between brain centers - is manifested strikin | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| HEALTHPARTNERS RESEARCH FOUNDATION | $853,730 | Grant | Trans-NIH Recovery Act Research Support: Computer Assisted Guidance for Tobacco Dependence Interventions in Dental Offices Electronic health records (EDR) represent a powerful tool for incorporating best practice guidelines into the dental treatment encounter through the use of clinical decisio | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $918,199 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (08) Genomics Topic: 08-DE-103: Epigenomics and Epigenetics of Oral Health and Disease. The standard paradigm for characterization of genome wide epigenetic alteration in human cancers has been focused on di | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| TEXAS A&M UNIVERSITY SYSTEM,THE | $762,727 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad challenge area (15): Translational Science, and specific Challenge Topic 15-DE-104: Functional Restoration of Salivary Glands. Hypofunction of salivary gland is a common pathological condition in patients with Sj'gren's sy | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $1,012,143 | Grant | Trans-NIH Recovery Act Research Support: The sizable weight losses seen with bariatric surgery are often associated with improvements or resolution of several obesity related comorbidities, including type 2 diabetes. The proposed project is designed to investigate the mechanism by which Roux en | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| KAISER FOUNDATION HOSPITALS | $496,680 | Grant | Trans-NIH Recovery Act Research Support: In this study, we will evaluate the prevalence of non-utilization and persistent (repeated) non-utilization for referred health services for diabetes. We will then evaluate social disparities and other patient-, provider- and system-level predictors of no | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| BAYLOR COLLEGE OF MEDICINE | $646,697 | Grant | Trans-NIH Recovery Act Research Support: This proposal will address core items in Challenge Area 08 (Genomics), specifically targeting Challenge Topic 08-DK-107, Nuclear receptor mediated assembly of functional transcription units. In relation to this application, this Challenge Topic states: -? | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $997,851 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (07) Enhancing Clinical Trials and specific Challenge Topic, 07-DK-103: Support for Registries. Live donor kidney transplantation is the best treatment for kidney failure, doubling life expectancy and signif | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| DUKE UNIVERSITY | $999,385 | Grant | Trans-NIH Recovery Act Research Support: The risk for developing end-stage renal disease (ESRD) in African Americans is more than 3-fold higher than European Americans. This disproportionate risk is apparent for virtually all forms of kidney disease, but only a minor portion can be explained by | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| CHILDRENS HOSPITAL OF PHILADELPHIA | $958,961 | Grant | Trans-NIH Recovery Act Research Support: The Children's Hospital of Philadelphia (CHOP) contributes substantially to the local economy. In 2008, CHOP's operations created and supported over 16,882 jobs in the region, and CHOP's total economic impact was over $5.9 billion. Moreover, through a com | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| THOMAS JEFFERSON UNIVERSITY | $894,942 | Grant | Trans-NIH Recovery Act Research Support: Common complications of portal hypertension include gastroesophageal varices, ascites, and portasystemic encephalopathy. Patients with cirrhosis have a 5-10% yearly incidence of variceal formation, and a 4-15% yearly incidence of bleeding. Each bleeding e | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF ARIZONA | $544,545 | Grant | Trans-NIH Recovery Act Research Support: The use of multimodality PET/CT or SPECT/CT has increased substantially in recent years. The use of both an anatomical imaging modality and a functional one provides an extra image dataset for diagnosis, can improve the reconstruction of the functional da | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $999,965 | Grant | Trans-NIH Recovery Act Research Support: The prevalence of abdominal aortic aneurysms (AAA), has increased significantly, affecting 5-7% of Americans over age 60. Endovascular aneurysm repair has been shown to be a safe and effective treatment for AAA disease. Currently, there are 5 FDA approved | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| NORTH CAROLINA STATE UNIVERSITY | $716,161 | Grant | Trans-NIH Recovery Act Research Support: Environmental toxins, such as the herbicide paraquat, cause neuronal cell death through oxidative stress. Locomotor impairments are sensitive indicators of neurodegeneration. A long-standing challenge in environmental health science is to assess the effec | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF ARIZONA | $938,801 | Grant | Trans-NIH Recovery Act Research Support: Mounting evidence suggests that environmental exposures, particularly when occurring at a critical developmental window in early life, can profoundly affect the phenotypes associated with complex diseases such as allergic asthma. In particular, several lo | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| NORTHWESTERN UNIVERSITY | $995,214 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (08) Genomics and specific Challenge Topic, 08-ES-104: Identification of alterations in epigenetic marks related to environmental exposures. In the US, over one million people are occupationally exposed to p | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: Air pollution, particularly O3, induces exacerbations of asthma that substantially worsen morbidity and mortality. In healthy individuals inhalation of O3 elicits mechanisms such as homeostatic increase in SP D synthesis that protect the lung from develop | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, THE | $855,159 | Grant | Trans-NIH Recovery Act Research Support: The application of PET to evaluate the health and safety of nanomaterials will offer a deep and broad understanding of nanoparticle behavior, revealing the pathways nanomaterials take in living systems and identifying some of the acute and long-term effec | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $985,501 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area, (08) Genomics and Specific Challenge Topic, 08-ES-106: The role of environmental exposure in copy number variation (CNV): 'Microscopic deletions and replications of the genome have attracted increasing atte | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad challenge area (06), Enabling Technologies, and specific Challenge Topic 06-GM-109: Green chemistry and engineering for drug discovery, development and production. | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF MARYLAND | $860,237 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad the Challenge Area (06) Enabling Technologies and Specific Challenge Topic 06-GM-106; subcellular imaging of metal ions. Methods to improve spatial resolution are complex and not always compatible with cell imaging. For ex | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF FLORIDA | $965,446 | Grant | Trans-NIH Recovery Act Research Support: Induced pluripotent stem cells (iPSCs) are the most expected cellular sources for regenerative medicine and hold tremendous therapeutic potential. Many groups have shown that adult fibroblasts and epithelial cells can be reprogrammed to a pluripotent, ESC | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERISTY OF MISSISSIPPI MEDICAL CENTER | $973,538 | Grant | Trans-NIH Recovery Act Research Support: In the work to be supported by this award, we will: 1) Extend the best methodology for imputation to African Americans, producing public-domain software to execute these analyses, validating our methods, and providing a public-domain database of all known | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $948,598 | Grant | Trans-NIH Recovery Act Research Support: Motions that contribute to biomolecular recognition occur on all timescales, but in contrast to relatively slow dynamics, which may be characterized by a variety of well developed techniques, there are no techniques thatmay be used to characterizing relat | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: RNA interference (RNAi) functions as an antiviral immunity in fungi, plants, insects and nematodes. In this immunity, dsRNA produced during replication of viral RNA genomes or convergent transcription of viral DNA genomes is processed into 21- to 24-nucle | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| NATIONAL JEWISH HEALTH | $930,848 | Grant | Trans-NIH Recovery Act Research Support: The challenge addressed in this proposal is to better understand the remarkable increase in the prevalence of atopic diseases (atopic dermatitis (AD), food allergy, asthma, and atopic rhinitis) over the last 4-5 decades and the extent to which epigenetic | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $900,485 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to generate evidence-based measures of the effectiveness of 65 federally-funded teacher professional development institutes for middle school life science teachers. Such institutes typically meet for a week or longer during sum | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $997,507 | Grant | Trans-NIH Recovery Act Research Support: This application addresses Broad Challenge Area (12): Science, Technology, Engineering, and Mathematics (STEM) and Specific Challenge Topic, 01-OD-101: Efficacy of Educational Approaches Toward Promoting STEM. This project will test the efficacy of a full | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $999,544 | Grant | Trans-NIH Recovery Act Research Support: The proposal has 2 specific aims: Specific Aim 1: To use versatile reporter gene constructs to understand the biology and physiology of cardiac stem cells in vivo. Specific Aim 2: To track cell fate in pre-clinical large animal models using combined PE | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | $415,578 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (06): Enabling Technologies and specific Challenge Topic, 06-HL-103: Develop new imaging methodologies to track cells and measure accurately the chemical activities of en | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| VIRGINIA COMMONWEALTH UNIVERSITY | $467,596 | Grant | Trans-NIH Recovery Act Research Support: Despite major roles played by heparin and heparan sulfate in growth and morphology, coagulation, angiogenesis, immune response and viral infection, their interaction with nearly all proteins, except for antithrombin, remains poorly defined. The events of | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $500,000 | Grant | Trans-NIH Recovery Act Research Support: Faculty at Case Western Reserve University and its Comprehensive Cancer Center with key collaborators at the University of Kentucky, and University of Minnesota propose to develop a novel stem cell graft engineering approach that will address the known li | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF IOWA, THE | $998,944 | Grant | Trans-NIH Recovery Act Research Support: This application addresses two broad Challenge Areas and three associated specific Challenge Topics including: i) the broad Challenge Area (06) Enabling Technologies, specific Challenge Topic 06-HL- 105: Develop transgenic animal models that are informati | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $932,526 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this study is to develop and validate a novel cell basedhigh throughput, high content, vascular health profile analysis that provides a signature for individualsat high risk for cardiovascular events. A unique biocomputational approach | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| DUKE UNIVERSITY | $999,815 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area #8, Genomics, and specific Challenge Topic 08-HL-101, which seeks to identify causal genetic variants associated with heart, lung, and blood diseases by application of targeted DNA capture and massively para | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF WASHINGTON | $450,818 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Are on Clinical Research (04) with the specific challenge on Perform secondary analyses of existing data to answer important clinical and preventive medicine research questions: 04-HL-104.An estimate of a person' | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $822,913 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (04) Clinical Research and specific Challenge Topic (04-HL- 103): Assess the role of leukocyte interactions with platelets, erythrocytes, and endothelium in the pathogenesis of heart, lung, and blood disease | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $1,002,381 | Grant | Trans-NIH Recovery Act Research Support: T cells develop in the thymus from blood cell progenitors. The identity of molecules that allow some blood cell progenitors to migrate to the thymus is unknown. We propose to identify molecules that support trafficking of progenitors to the thymus, to ide | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $757,500 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (04) Clinical Research, and the specific Challenge Topic, 04-AI-101: Develop novel methods and address key questions in mucosal immunology. The long-term goal of this project is to understand how natural kil | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $998,928 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This application addresses Challenge Area 10 and specific Challenge Topic 10-HL- 101*,'Information Technology for Processing Healthcare Data for Research,' specifically to the challenge topic 10-HL-101*, 'Develop data | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| BAYLOR COLLEGE OF MEDICINE | $60,444 | Grant | Trans-NIH Recovery Act Research Support: PURPOSE:Elucidation of the mechanisms through which diet modulates physiology and aging will lead to interventions to reduce the frequency of aging-related diseases. ABSTRACT:Aging is a progressive decline in biological functioncharacterized by increased | Health and Human Services, Department of / National Institutes of Health | 5/19/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $71,917 | Grant | Trans-NIH Recovery Act Research Support: Tuberculosis (TB) continues to kill millions of people around the world. New tools to prevent and treat this disease are urgently needed. Iron is an essential metal for all forms of life and most bacterial pathogens including Mycobacterium tuberculosis ( | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $65,980 | Grant | Trans-NIH Recovery Act Research Support: This Administrative Supplement if for salary support for a graduate research assistant who is a memeber of an under-represented minority in biomedical science. The research is an extension of the current active project (AI24421) and will entail testing h | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $82,556 | Grant | Trans-NIH Recovery Act Research Support: C. glabrata is an important opportunistic pathogen causing mucosal infection in healthy individuals and disseminated infection in immunocompromised, primarily hospitalized, patients, responsible for approximately 20% of all candidemias. The Cormack lab is | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| MEHARRY MEDICAL COLLEGE | $71,132 | Grant | Trans-NIH Recovery Act Research Support: Trypanosoma brucei is a group of hemoflagellated parasitic protozoa that causes a fatal disease in humans known as African sleeping sickness and a similar diseases in domestic animals called nagana. The disease is transmitted by an insect vector, the tset | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $65,156 | Grant | Trans-NIH Recovery Act Research Support: This proposed study will address this increasing health concern by characterizing the bioactive potential of a marine bacterium, Genus Pseudovibrio, isolated from a Caribbean coral that is shown to produce a number of antimicrobials in preliminary screeni | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| THE VANDERBILT UNIVERSITY | $69,756 | Grant | Trans-NIH Recovery Act Research Support: The overarching goal of this fellowship application is to provide support for work which will focus on dissecting the structure-function relationships in ribonucleoprotein (RNP) complexes that mediate post-transcriptional gene regulation in viruses with d | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| UNIVERSITY OF MARYLAND | $58,004 | Grant | Trans-NIH Recovery Act Research Support: One of the most striking effects reported by male and female users of methamphetamine, a highly addictive psychostimulant drug of abuse, is an increase in sexual libido and an insatiable need and urgency for sex. In addition, female methamphetamine users | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| WAKE FOREST UNIVERSITY | $8,342 | Grant | Trans-NIH Recovery Act Research Support: This research seeks to determine the role that extracellular matrix (ECM) plays in the aging of skeletal muscle. Skeletal muscle tissue is maintained via the regenerative capacity of the tissue's resident stem/progenitor cells known as satellite cells or | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $97,684 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to understand the process by which the pathogenic bacterium Pseudomonas aeruginosa kills the nematode worm Caenorhabditis elegans. C. elegans has recently been developed as a host model for a number of pathogens. Work in the Au | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $97,684 | Grant | Trans-NIH Recovery Act Research Support: Investigating host genetic polymorphisms contributing to influenza virus disease The goal of this project is to identify polymorphic host genes that regulate the susceptibility to influenza virus in the mouse, while assessing the role of Mx1 polymorphism | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $51,710 | Grant | Trans-NIH Recovery Act Research Support: Organ transplantation is thus far the only cure for patients with a terminal organ failure. Understanding immunological mechanisms underlying graft tolerance vs. graft rejection is critical in clinical transplantation and improving quality of life in tran | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON | $105,520 | Grant | Trans-NIH Recovery Act Research Support: CD4 T helper cell differentiation is controlled by G??masterG?? transcription factors that commit the cell to become a Th1, Th2 or Th17 cell or a Treg. It was previously believed that the expression of these transcription factors was mutually exclusive. H | Health and Human Services, Department of / National Institutes of Health | 7/23/2009 |
| UNIVERSITY OF NEW MEXICO | $97,684 | Grant | Trans-NIH Recovery Act Research Support: Our long-term objectives are to understand the evolution of arboviruses in the context of their transmission cycles and how this impacts viral emergence, adaptation and persistence. WNV genetic diversity is greater in mosquitoes than birds in both nature | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $92,824 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Many pathogens utilize clonal variation to diversify their antigenic or virulence factors to promote infection, a process termed virulence modulation (VMO). The aims presented within this application will serve to char | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $102,208 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this project is to explore the effects of antigen exposure on T cell quantity and quality in mucosal tissues. This award will result in furthering our knowledge in the above topic as well as foster the further education and support of a pos | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF PITTSBURGH THE | $290,204 | Grant | Trans-NIH Recovery Act Research Support: This is a facility improvement project specifically to accomplish the following: 1.To ensure the occupational health and safety of personnel and to provide enhanced research animal communicable disease prevention through replacement of obsolete and/or un | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| HOUSE RESEARCH INSTITUTE | $1,782,584 | Grant | Trans-NIH Recovery Act Research Support: This is a grant to enable successful recruitment of new Jr. Faculty into the recently reorganized cores, Cell Biology and Genetics (CB&G and Communication and Auditory Neuroscience (CAN). | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $606,494 | Grant | Trans-NIH Recovery Act Research Support: This application is a response to RFA-OD-09-005 NIHGMS, Supporting New Faculty Recruitment to Enhance Research Resources through Biomedical Research Core Centers. The request is for recruitment of a new assistant professor to the Biochemistry Division at | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF MASSACHUSETTS | $821,354 | Grant | Trans-NIH Recovery Act Research Support: TLR4 Signaling in alcoholic liver disease, Award Number R01AA017729 from the National Institute On Alcohol Abuse And Alcoholism (NIAAA), is aimed at investigating the role of Toll-like receptor 4-dependent signaling in experimental alcoholic liver disease | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| UNIVERSITY OF TENNESSEE | $945,128 | Grant | Trans-NIH Recovery Act Research Support: Alzheimer's disease is characterized by the aggregation of 13-amyloid (A13) protein in the brain, widespread neurodegeration, and cognitive decline. Our work focuses on amelioration of Alzheimer's pathology by reducing or simplifying the major brain gang | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| YALE UNIVERSITY | $631,892 | Grant | Trans-NIH Recovery Act Research Support: Salmonella enterica serovar Typhi (S. Typhi), the cause of typhoid fever in humans, continues to be a very significant health problem. It is estimated that there are 16,000,000 cases of typhoid fever every year, resulting in 600,000 deaths. Unlike other S | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $770,000 | Grant | Trans-NIH Recovery Act Research Support: RETROCYCLINS: CYCLIC MINI-DEFENSINS THAT INACTIVATE ANTHRAX TOXINS . The broad objectives of this research are to develop a new class of therapeutic agents, retrocyclins, that can be used to treat bacterial and viral infections. In the original submissio | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| YALE UNIVERSITY | $823,948 | Grant | Trans-NIH Recovery Act Research Support: Compelling evidence suggests that alteration of normal prenatal development influences one's lifetime risks for obesity and cardiovascular disorders, which are components of the 'metabolic syndrome. Reflecting the public health importance of elucidating | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $1,538,253 | Grant | Trans-NIH Recovery Act Research Support: Families with Latino backgrounds now represent the largest ethnic minority group in the United States, and adolescents wtihin the$8 families face substantial challenges to their psychological and behavioral adjustment. Emerging evidence indicates that tra | Health and Human Services, Department of / National Institutes of Health | 8/24/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $1,090,114 | Grant | Trans-NIH Recovery Act Research Support: Autism is a tremendously heterogeneous disorder with complex genetic and neural underpinnings. This grant aims to understand variability in the autism phenotype by examining links between known genetic risk factors for autism and brain structure and funct | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| YALE UNIVERSITY | $1,234,230 | Grant | Trans-NIH Recovery Act Research Support: We will use fMRl to characterize the neural basis of development in social cogntion. Our understanding of the pathogenesis of psychiatric disorders that affect social cognition and social behavior (e.g., autism, anxiety disorders, anorexia, and schizophre | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC. | $708,116 | Grant | Trans-NIH Recovery Act Research Support: We propose to investigate the role of epileptic seizures in oxidative stress. There is a wealth of research that demonstrates epileptic seizures lead to the formation of reactive oxygen species (ROS), which cause oxidative damage to DNA, lipids, and prot | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| YALE UNIVERSITY | $194,700 | Grant | Trans-NIH Recovery Act Research Support: The proposed experiments will directly impact public health by developing a novel paradigm to investigate nicotine-induced dopamine release in vivo. These studies will examine the effects of nicotine and the treatment drug rimonabant in the brain to deter | Health and Human Services, Department of / National Institutes of Health | 5/04/2009 |
| YALE UNIVERSITY | $173,605 | Grant | Trans-NIH Recovery Act Research Support: The proposed study can make more efficient use of cancer genomic data by properly accounting for the clustering structure of gene expressions and selecting predictive cancer biomarkers. It can provide more insights into the genomic mechanisms of cancer oc | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $327,549 | Grant | Trans-NIH Recovery Act Research Support: TITLE: 'MARRIAGE, PHYSIOLOGY, AND HEALTH DURING THE RETIREMENT TRANSITION.' This longitudinal, observational research project will: 1) Determine whether poor marital functioning predicts greater physiological changes during marital discussions, and slowe | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | $430,705 | Grant | Trans-NIH Recovery Act Research Support: Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that form transmembrane, cation-permeable channels which open upon agonist binding. iGluRs are the major mediators of excitatory synaptic transmission in the central nervous system (CNS | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $423,500 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to develop live attenuated influenza virus vaccine. Influenza is a global infectious viral disease of great public health concern affecting millions of people every year. We plan to create highly attenuated PR8 viruses by rever | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | $525,250 | Grant | Trans-NIH Recovery Act Research Support: Type 1 diabetes (T1D) develops as control of autoreactive CD4 cells is lost, which occurs in part because of escalating responses of cells that escape regulation and are highly pathogenic. While many cell types contribute to this disease, ameliorating the | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| CHILDREN'S HOSPITAL & RESEARCH CENTER | $440,000 | Grant | Trans-NIH Recovery Act Research Support: The +?-hemoglobinopathies sickle cell disease and +?-thalassemia are among the most common, and most devastating, genetic diseases worldwide. In countries with developed health care systems, care for affected individuals is extremely expensive; in develop | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $456,374 | Grant | Trans-NIH Recovery Act Research Support: As the numbers of patients continue to rise after high-dose chemotherapy and/ or irradiation for cancer and other diseases, more attention is focused on improving their quality-of-life, with fertility one of the top priorities for young people. Women have | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| CHILDREN'S HOSPITAL & RESEARCH CENTER | $440,000 | Grant | Trans-NIH Recovery Act Research Support: Statins are widely used to reduce cardiovascular disease risk by lowering LDL cholesterol (C), but the magnitude of this effect varies widely among individuals. The overall objective of this proposal is to provide evidence in support of a novel pharmacoge | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $454,805 | Grant | Trans-NIH Recovery Act Research Support: Despite the growing number of evidence-based mental health treatments for youth being developed, few are effectively practiced routinely in community settings. One reason may be the lack of attention paid to how these treatments are implemented in the con | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $427,564 | Grant | Trans-NIH Recovery Act Research Support: This R21 proposal will explore whether abnormal white matter anatomical connections may underlie the gray matter (functional) abnormalities previously seen in fMRI data from subjects with bipolar disorder. We will collect, in the same subject, both diffus | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $305,300 | Grant | Trans-NIH Recovery Act Research Support: MEMORY, THIAMINE LEVELS AND BRAIN STRUCTURE IN HEART FAILURE Many heart failure (HF) patients have short-term memory deficits, which can adversely impact management of their disease and dramatically increase morbidity and mortality. Injury in brain areas | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $387,154 | Grant | Trans-NIH Recovery Act Research Support: Creation of 100-200 micron dimension probes with multiple electrode sites from silicon wafers for the monitoring of glutamate and dopamine simultaneously in the brains of live, laboratory rodents | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| YALE UNIVERSITY | $749,840 | Grant | Trans-NIH Recovery Act Research Support: The guiding question is whether early intervention can improve long term outcomes for psychotic disorders in the U.S. We hypothesize that a specialized multi-component intervention, delivered in a public mental health clinic will be more effective than us | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF ARKANSAS SYSTEM | $1,333,209 | Grant | Trans-NIH Recovery Act Research Support: Predicting Chemotherapy Induced Mucositis with Genetic and Clinical Factors. The broad long term objective is to use genotypic and clinical characteristics to improve individualized healthcare. Severe mucositis is a dose limiting toxicity of high dose mel | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $1,201,760 | Grant | Trans-NIH Recovery Act Research Support: Diabetes mellitus (DM) is a prevalent, costly condition with high morbidity and mortality. Our goal is to determine prospectively mechanisms by which type 2 DM alters cerebral microcirculation and contributes to brain tissue damage and cognitive decline i | Health and Human Services, Department of / National Institutes of Health | 8/12/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $1,179,084 | Grant | Trans-NIH Recovery Act Research Support: Alzheimer disease (AD) imposes a substantial societal burden. Clinical AD likely results through the interaction of 3 factors: reserve, AD- and vascular pathology. Brain MRI and cognitive tests can identify proxy measures of reserve and subclinical marker | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| HOWARD UNIVERSITY, INC. | $1,989,430 | Grant | Trans-NIH Recovery Act Research Support: The study is to determine whether African American with mild AD can be enrolled and retained in a six month aerobic exercise training in order to examine the effect of aerobic exercise training on neurocognitive functions and on celebral glucose homeostas | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| THE VANDERBILT UNIVERSITY | $887,453 | Grant | Trans-NIH Recovery Act Research Support: This proposalG??s primary objective is to (develop intervention and assessment) strategies that nursing homes (NHs) can use to improve how their staff members provide choice to residents about important activities of daily living. Providing choice to resi | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $62,039 | Grant | Trans-NIH Recovery Act Research Support: The primary objective of this project is to investigate the molecular mechanisms that underlie a genetically defined, natural transplantation reaction that occurs in the primitive chordate, Botryllus schlosseri. We have recently published the characteriza | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $55,643 | Grant | Trans-NIH Recovery Act Research Support: The 1918-20 influenza pandemic was the largest, most lethal epidemic in modern: history. It spread over the entire world in about six months and killed between 20 and 100 million people. Yet, despite such a devastating event, there is little detailed info | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $68,998 | Grant | Trans-NIH Recovery Act Research Support: Influenza virus is a seasonal pathogen with the potential to cause pandemic infection; it results in respiratory disease ranging from subclinical symptoms to life-threatening primary viral pneumonia. Despite the availability of a yearly vaccine, it is est | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $23,240 | Grant | Trans-NIH Recovery Act Research Support: Agent-based modeling of virus-host cell interaction in salivary gland disease: A computational model utilizing agent-based modeling will model the replication and assembly of the BK virus (BKV) within a salivary gland cell. BKV has recently been associat | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $1,358,529 | Grant | Trans-NIH Recovery Act Research Support: Although the sequencing of the human genome promised to transform basic and translational research, the catalogue of human genes that it delivered remain far from the type of predictive models that would allow us to rapidly develop hypotheses about the re | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $941,471 | Grant | Trans-NIH Recovery Act Research Support: Neuroinflammation in the central nervous system (CNS) is an important aspect of CNS injury, disease and neurodegeneratlon. The CNS production of proinflammatory cytokines and other neuroimmune molecules is thought to playa role in cognitive, behavior and | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| DUKE UNIVERSITY | $1,616,415 | Grant | Trans-NIH Recovery Act Research Support: This is an application for support from the Recovery Act Limited Competition for NIH Grants: Research to Address the Heterogeneity in Autism Spectrum Disorders (R01) RFA-MH-09-170. We propose to leverage ongoing collaboration among faculty at Duke Univers | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY SYSTEM OF NEW HAMPSHIRE | $139,938 | Grant | Trans-NIH Recovery Act Research Support: Numerous infectious diseases are caused by minority strains within otherwise nonpathogenic species, but the ecological and population genetic mechanisms that drive their emergence remains unclear. Understanding these dynamics is especially important in li | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $732,188 | Grant | Trans-NIH Recovery Act Research Support: Tuberculosis (TB) is a severe global health threat and the emergence of multiple drug resistant Mycobacterium tuberculosis (Mtb) strains elevates the threat to a truly alarming state. One third of the world is latently infected with Mtb and the organism | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF WASHINGTON | $780,000 | Grant | Trans-NIH Recovery Act Research Support: ABSTRACTIron is essential for virtually all forms of life and plays a central role in cellular metabolism. Microbes have developed complex strategies for the acquisition, storage, trafficking, utilization and detoxification of iron. One of the primary bi | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER | $710,764 | Grant | Trans-NIH Recovery Act Research Support: Candida is among the most common causes of nosocomial infections in the United States and worldwide. Even with antifungal therapy, disseminated candidiasis causes an unacceptable 40%-50% mortality. Furthermore, resistance to antifungal therapies among Can | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE | $830,000 | Grant | Trans-NIH Recovery Act Research Support: C57BL/6 (B6) mice are genetically resistant to fatal HSV encephalitis (HSE) compared to 129S6 (129) and BALB/c that are susceptible. We have shown that fatal HSE in 129 mice results from hyper-inflammatory responses involving macrophages and neutrophils a | Health and Human Services, Department of / National Institutes of Health | 6/17/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $794,414 | Grant | Trans-NIH Recovery Act Research Support: This proposal seeks to determine the mechanisms and receptors by which leukotriene (LT)E4, the most stable ligand of the cysteinyl leukotrienes (cys-LTs), activates mast cells (MCs) and promotes pulmonary inflammation. An abundance of historical informati | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $711,553 | Grant | Trans-NIH Recovery Act Research Support: HIV-1 Replication and Pathogenesis in vivo - ARRA The goals of this project are to define how HIV-1 interacts with pDC and to elucidate the role of pDC cells in HIV-1 replication and pathogenesis. As the major sensor of viral infections, altered pDC level | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| DONALD DANFORTH PLANT SCIENCE CENTER | $825,000 | Grant | Trans-NIH Recovery Act Research Support: Traditional viral vaccines are normally developed by either creating attenuated viral strains for inoculation, such as the Sabine strain of poliovirus, or by injecting the patients with purified viral proteins such as employed in the hepatitis B vaccine. | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | $942,308 | Grant | Trans-NIH Recovery Act Research Support: M. tuberculosis infection is an ongoing global health crisis that requires new drugs or vaccines for effective control. Although many individual genes have been shown to be important for M. tuberculosis pathogenesis in the mouse, we still understand relat | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $755,000 | Grant | Trans-NIH Recovery Act Research Support: Effective control of systemic autoimmune diseases such as rheumatoid arthritis (RA) currently relies on the use of intense generalized immunosuppression, thus increasing the risk of infection and malignancy. A better theoretical approach to the treatment | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $807,497 | Grant | Trans-NIH Recovery Act Research Support: This project is to investigate the mechanism of activation of the interferon regulatory factor (particularly IRF-3) following virus infection.-? The activation of IRFs, which is triggered by the phosphorylation of certain Ser/Thr residues, results in its | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $759,922 | Grant | Trans-NIH Recovery Act Research Support: Antibiotic resistance is a looming global problem threatening some of the most significant public health gains of the past century. This critical health challenge, together with the emerging threat of biowarfare agents calls for the identification and dev | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| PALO ALTO INSTITUTE FOR RESEARCH AND EDUCATION, INC. | $716,000 | Grant | Trans-NIH Recovery Act Research Support: Our goal for this 2 year award is to define in detail the therapeutic potential of recently identified tolerogenic DC populations in graft versus host disease (GVHD). We have recently identified CCR9- expressing plasmacytoid DCs as an extremely potent tol | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $732,292 | Grant | Trans-NIH Recovery Act Research Support: The use of Bacillus anthracis as a bioweapon depends on dispersal of its spores in the environment, entrance into the body, spore uptake by the human host cells, germination of the spores in the host and the pathological consequences of the host response | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $745,738 | Grant | Trans-NIH Recovery Act Research Support: Bacterial infections constitute one of the major health problems worldwide. A gradual increase in the resistance to antibiotics leads to a serious thread for successful treatment of bacterial infections. This feature has stimulated the interest in vaccine | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| CORNELL UNIVERSITY, INC | $736,240 | Grant | Trans-NIH Recovery Act Research Support: Resistance to infection is determined by immune system activity and the overall physiological condition of the host. This project will determine how the seemingly disparate physiological processes of immunity, metabolism and reproduction are genetically l | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $888,678 | Grant | Trans-NIH Recovery Act Research Support: This project will characterize and develop the ability to transcriptionally modulate HIV-l latency. We have recently discovered that antisense non-coding RNAs can regulate gene transcription and evidence suggests that HIV-l also utilizes this mechanism to | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $779,970 | Grant | Trans-NIH Recovery Act Research Support: Major developments in molecular biology, coupled with strides in genomics and proteomics, have led to an explosive growth in biological data. To obtain usable, relevant information from these vast databases (e.g. through data mining) it is mandatory to us | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF TEXAS AT SAN ANTONIO | $679,457 | Grant | Trans-NIH Recovery Act Research Support: As a major reason of osteoporotic and age-related fractures, deterioration of bone quality is reflected mainly in the reduced toughness. Recent evidence has evinced that bone may experience two distinct stages in the post-yield deformation: beginning with | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| GEORGIA TECH RESEARCH CORPORATION | $1,274,015 | Grant | Trans-NIH Recovery Act Research Support: The robust regeneration potential of fetal tissue suggests that developmental biology may help guide strategies for tissue regeneration in adults. Decreases in regenerative capacity post-utero and with increasing age are likely due to multiple factors, ho | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $1,367,703 | Grant | Trans-NIH Recovery Act Research Support: The U.S. Department of Health & Human Services and the National Recreation & Park Association both recommend Yoga as a form of total-solution exercise for older adults, capable of providing cardiovascular fitness, resistance training for muscle strength & | Health and Human Services, Department of / National Institutes of Health | 6/29/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $694,009 | Grant | Trans-NIH Recovery Act Research Support: The increase in T cell numbers associated with Sezary Syndrome likely occurs as a result of hyperproliferation as well as decreased apoptosis. The mechanisms involved resulting in these effects however are not clearly understood. We have previously report | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON | $619,988 | Grant | Trans-NIH Recovery Act Research Support: Cyclooxygenase (COX) inhibitors lower the risk of colorectal cancer (CRC) and inhibit tumor growth in animal and cell culture models. However, their efficacy in treating existing CRC remains controversial. Previous research in our laboratory has demonstra | Health and Human Services, Department of / National Institutes of Health | 5/13/2009 |
| VIRGINIA COMMONWEALTH UNIVERSITY | $620,339 | Grant | Trans-NIH Recovery Act Research Support: Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) is a pleotrophic tumor suppressor molecule that exhibits the unique property of inducing apoptosis only in cancer cells. Dietary monoterpenes, such as perillyl alcohol (POH) also exhi | Health and Human Services, Department of / National Institutes of Health | 6/25/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $665,984 | Grant | Trans-NIH Recovery Act Research Support: Our long-term objectives are 1) to develop appropriate molecular probes for in vivo multimodality imaging of tumor angiogenesis, growth, and metastasis and 2) to use molecular imaging techniques to predict and monitor treatment efficacy. The intermediate | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | $949,034 | Grant | Trans-NIH Recovery Act Research Support: While understanding the trade-off between tumor control probability and normal tissue complication probability lies at the heart of radiotherapy treatment planning, the reporting of the dependence of complications on dose distributions is currently inadeq | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| WASHINGTON UNIVERSITY, THE | $625,621 | Grant | Trans-NIH Recovery Act Research Support: The breast cancer susceptibility gene 1 (Brca1) plays a key role in both hereditary and sporadic mammary tumorigenesis. However, the extent to which BRCA1-activated molecular pathways contribute to its tumor suppressor activity also remains unclear. Activ | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $713,042 | Grant | Trans-NIH Recovery Act Research Support: Studies in this proposal will help to understand how stem cells are maintained in the adult mammalian organism and whether abnormalities with stem cells are responsible for cancer. Knowledge obtained during this study will help to develop new therapies fo | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $1,032,869 | Grant | Trans-NIH Recovery Act Research Support: Overall Purpose To determine whether the Tg11.5kb-GFP mouse is a suitable model for analyses of adult stem cell activity, and if so, how best can this mouse model be used to demonstrate specific properties, functions and potential utilizations for human d | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| WISTAR INSTITUTE OF ANATOMY & BIOLOGY | $993,896 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this application is to discover and validate multiple novel plasma protein biomarkers of human ovarian cancer. We will initially discover a substantial number of candidate biomarkers through parallel analysis of two complementary model | Health and Human Services, Department of / National Institutes of Health | 6/29/2009 |
| WAKE FOREST UNIVERSITY | $1,116,642 | Grant | Trans-NIH Recovery Act Research Support: Genetic alterations and epigenetic modifications are hallmarks of cancers, including prostate cancer (PCa). Understanding factors associated with the progression of PCa will have a significant impact on management and treatment of the disease. We hypothes | Health and Human Services, Department of / National Institutes of Health | 8/12/2009 |
| DUKE UNIVERSITY | $647,400 | Grant | Trans-NIH Recovery Act Research Support: HDAC inhibitors (HDACI) are promising anti-tumor agents that have just entered the clinics. Despite their potent activity, the fundamental question of how HDAC inhibitors achieve their anti-tumor effects remains poorly understood. It is not known which of | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | $595,759 | Grant | Trans-NIH Recovery Act Research Support: Previous studies revealed that certain integrins expressed on endothelial cells play a significant role in the progression of angiogenesis and are an attractive target for the development of angiostatic drugs that may have an application in the therapy of | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| VIRGINIA COMMONWEALTH UNIVERSITY | $544,131 | Grant | Trans-NIH Recovery Act Research Support: Targeting tumor vessels has become a mainstream mode of treatment for a variety of malignancies. In addition to anti-angiogenic therapy, vascular disrupting agents (VDAs) are a new group of compounds that selectively kill tumor endothelial cells and suppr | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | $786,840 | Grant | Trans-NIH Recovery Act Research Support: In collaboration with the structural biologist Dr. Hao Wu, we solved the co-crystal structure of one of the compounds in complex with caspase-7. The crystal structure revealed the allosteric nature of the binding and also provides guidance for future med | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $618,349 | Grant | Trans-NIH Recovery Act Research Support: This proposal seeks to develop and apply a new strategy of cancer therapy through the use of aptamers against target proteins and cells. It focuses on the Basal-like Breast Carcinoma (BLBC), which is a particularly aggressive subtype of breast cancer refr | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| UNIVERSITY OF IOWA, THE | $617,103 | Grant | Trans-NIH Recovery Act Research Support: Juvenile Polyposis (JP) is an autosomal dominant syndrome predisposing to the development of hamartomatous polyps of the colon, rectum, and stomach. Affected patients have an approximately 50% risk of developing gastrointestinal cancer. Work in our labora | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC. | $690,347 | Grant | Trans-NIH Recovery Act Research Support: Development of a laser holography otoscope for diagnosis in the clinic Conductive hearing loss, usually associated with middle-ear disorders, is the most common reason for otologic surgery. The pathogenesis of conductive loss includes, among others, acut | Health and Human Services, Department of / National Institutes of Health | 6/30/2009 |
| UNIVERSITY OF ROCHESTER | $755,599 | Grant | Trans-NIH Recovery Act Research Support: The developing mouse tooth has long been used as a powerful model system for studying the molecular mechanisms regulating organ development and the pathogenic mechanisms of tooth developmental anomalies in humans. Tissue recombination studies and extensiv | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $813,050 | Grant | Trans-NIH Recovery Act Research Support: Bone marrow mesenchymal stem cells (BMMSCs) are multipotent stem cells capable of differentiating into different lineage cells including osteoblasts, chondrocytes, adipocytes, cardiomyocytes, myoblasts, and neural cells. A recent major breakthrough was th | Health and Human Services, Department of / National Institutes of Health | 8/15/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $811,875 | Grant | Trans-NIH Recovery Act Research Support: Amelogenesis imperfecta (AI) is a group of diverse inherited disorders most often considered as a single trait and not often associated with syndromes or metabolic disorders. However, there have been documented case reports in which AI has been identified | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE INC | $53,600 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this project involves the establishment and analysis of a new autoimmune(AI) mouse model where T cells that are self-reactive escape deletion due to a defect in the presentation of tissue specific antigens (TSAs) in the thymus. The Aut | Health and Human Services, Department of / National Institutes of Health | 7/23/2009 |
| BROWN UNIVERSITY IN PROVIDENCE IN STATE OF RI AND PROVIDENCE PLANTATIONS | $79,378 | Grant | Trans-NIH Recovery Act Research Support: Gastric carcinoma is the second most common cause of cancer related deaths worldwide. Helicobacter pylori (H. pylori) has been identified as a major causative agent in gastric cancer. H. pylori infection is common worldwide, acquired during childhood and | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| YALE UNIVERSITY | $86,531 | Grant | Trans-NIH Recovery Act Research Support: There is now growing evidence that livestock may be involved in spread of community-associated Methicillin Resistant Staphylococcus aureus (CA-MRSA) recent studies from Europe and Canada report a new strain (ST 398) that maybe associated with pig farming. | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $73,982 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Many signaling cascades have been implicated in hematopoietic development. Among these is the wnt pathway, which has been proposed to be involved in the self-renewal of hematopoietic stem cells (HSCs) and in sustaining | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| PUBLIC HEALTH, MASSACHUSETTS DEPT OF | $928,138 | Grant | Trans-NIH Recovery Act Research Support: Massachusetts Department of Public Health (MDPH) received a two year award of $928,138 in direct costs from the National Institute of Environmental Health Sciences to support the Reducing Ethnic/Racial Asthma Disparities in Youth (READY) study. A no-cost | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON | $755,000 | Grant | Trans-NIH Recovery Act Research Support: Uveitis, an ocular inflammatory disease of unknown etiology, is a major complication during autoimmune disorders and infections and is associated with severe visual impairment. Uveitis may result from direct involvement of the uveal tract or indirect infl | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF WASHINGTON | $999,807 | Grant | Trans-NIH Recovery Act Research Support: The blood brain barrier (BBB) is a significant barrier to delivery of drugs to the central nervous system (CNS) and in removal of potential toxins produced within the CNS (e.g. beta-amyloid). In contrast to the endothelial cell barrier in other organs, t | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: Glioblastoma is the most common primary brain tumor and is considered to be among the deadliest of human cancers. The metabolism of the cells is much higher than normal cells and, like many cancers, represents a possible target for new drugs in cancer the | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $952,729 | Grant | Trans-NIH Recovery Act Research Support: This work addresses broad Challenge Area (15) Translational Science, and specific Challenge Topic Applied Translational Technology Development. Mechanical ventilation is a life support procedure that is indicated for a wide variety of acute or chronic res | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| EMORY UNIVERSITY | $1,998,560 | Grant | Trans-NIH Recovery Act Research Support: Nanotechnology for Multiplexed and Intraoperative Cancer Detection; This grant application aims to develop new and innovative technologies for applications in cancer surgery. The main goals are to help the surgeon to delineate tumor margins, to identify | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| OHIO STATE UNIVERSITY, THE | $4,057,634 | Grant | Trans-NIH Recovery Act Research Support: MicroRNAs contribute to the pathogenesis of human cancer by regulating the expression of oncogenes and tumor suppressor genes. In fact, loss of miR-15a and miR-16-1 leads to overexpression of BCL2 and MCL1 and the development of CLL, while overexpression | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $1,506,522 | Grant | Trans-NIH Recovery Act Research Support: Hypertension remains a hugely costly problem in the United States in terms of morbidity and economic burden. Many patients cannot or will not take medications; the application proposes a non-pharmacological intervention that will help hypertensive patient | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON | $860,260 | Grant | Trans-NIH Recovery Act Research Support: Hypertension affects nearly one-third of adults over age 20 in the United States. While hypertension is found in <10% in adults 20 - 34 years of age, it develops over a period of years, and blood pressure levels in children and adolescents are correlated | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| MCLEAN HOSPITAL CORPORATION, THE | $3,700,091 | Grant | Trans-NIH Recovery Act Research Support: We have developed a plan for a NINDS research organization/consortium to develop, characterize and study iPS cell lines for Parkinson's disease (PD). The overall goal of this consortium of multiple- Pis (see leadership plan) is to organize the rapidly exp | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| WASHINGTON UNIVERSITY, THE | $604,527 | Grant | Trans-NIH Recovery Act Research Support: Restoration of functional grasping would be of great benefit to people with hemiparesis post stroke. While task-specific training may be the best way to promote functional recovery, implementing such training for grasping is difficult because there are an | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF PITTSBURGH THE | $1,151,244 | Grant | Trans-NIH Recovery Act Research Support: Novel Approaches to Screening for Inflicted Childhood Neurotrauma Inflicted childhood neurotrauma (ICN) - traumatic brain injury due to child abuse - is the leading cause of death from traumatic brain injury (TBI) in children less than 2 yrs of age. Rec | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $2,672,711 | Grant | Trans-NIH Recovery Act Research Support: Tuberculosis (TB) is an infectious disease of global importance; in 2006, there were more than 9 million incident cases and 1.7 million deaths attributable to TB. The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB and the c | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $61,806 | Grant | Trans-NIH Recovery Act Research Support: The Retinoblastoma (RB) protein is a critical regulator of cell cycle progression, senescence, and differentiation. Our long-term goal is to better understand the cellular mechanisms controlling RB function in mammalian cells, focusing on the modification | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $26,174 | Grant | Trans-NIH Recovery Act Research Support: A molecular dynamics study of Amyloid beta peptide structure near lipid bilayers. Alzheimer?s disease is quickly becoming a major cause of death throughout the world, especially among the elderly population in developed nations. Thus, it is imperative th | Health and Human Services, Department of / National Institutes of Health | 5/19/2009 |
| UNIVERSITY OF PITTSBURGH THE | $55,245 | Grant | Trans-NIH Recovery Act Research Support: Estradiol has been shown to enhance basal forebrain cholinergic function and cognitive performance, but the mechanism by which estradiol exerts these effects is unknown. GPR30 is a novel estrogen receptor that is expressed in the brain and other tissues, | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| DUKE UNIVERSITY | $82,556 | Grant | Trans-NIH Recovery Act Research Support: As people get older, they confront a variety of negative life events, including physical and mental changes and the loss of social relationships. In spite of these changes, many older adults maintain relatively high subjective well-being, raising question | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $0 | Grant | Trans-NIH Recovery Act Research Support: This award was declined. | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| CHILDRENS HOSPITAL OF PHILADELPHIA | $61,611 | Grant | Trans-NIH Recovery Act Research Support: Between 2001-2003 there were 11.6 million annual ambulatory care visits for skin and soft tissue infections, with a 31% increase in emergency department visits compared to the previous decade, according to the National Hospital AmbulatoryMedical Care Surv | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $108,436 | Grant | Trans-NIH Recovery Act Research Support: Technical Summary The broad, long-term objective of this proposal is to test the overall hypothesis that Neutrophil Extracellular traps (NETs) contain posttranslationally modified self-antigens, and that the resultant, normally cryptic epitopes can break | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $97,684 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Many bacteria regulate virulence factor expression as a function of their population density. This phenomenon, known as 'quorum sensing' (QS), is driven by the detection of a variety of small molecules, collectively re | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| TRUSTEES OF PRINCETON UNIVERSITY, THE | $40,858 | Grant | Trans-NIH Recovery Act Research Support: Malaria is an infectious disease caused by Plasmodium falciparum, a protozoan parasite. In 2002, an estimated 2.2 million people were exposed to the threat of malaria with an estimate of 515 million clinical attacks, resulting in over a million deaths. Dr | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $41,415 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): A series of coordinating events must occur for an intracellular bacteria to gain entry into and establish infection within its host cell. This application is directed at understanding the molecular signals required for | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| UNIVERSITY OF WASHINGTON | $117,112 | Grant | Trans-NIH Recovery Act Research Support: The lung represents a major interface between the external world and our bodies. Thus, the lung must be able to effectively resist injurious agents while preventing an over-exuberant inflammatory response. When this does not occur, unregulated inflammat | Health and Human Services, Department of / National Institutes of Health | 7/23/2009 |
| THOMAS JEFFERSON UNIVERSITY | $875,280 | Grant | Trans-NIH Recovery Act Research Support: Infection associated with allograft transplantation and prosthesis use can occur in any patient, and is particularly prevalent and challenging in immunocompromised individuals. When developed, infection can lead to prolonged disability with immense psycho | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $631,983 | Grant | Trans-NIH Recovery Act Research Support: AMP-activated protein kinase (AMPK) coordinates metabolism with energy availability in eukaryotes by responding to changes in intracellular ATP and AMP levels. The kinase activity of AMPK is stimulated by AMP and inhibited by excess ATP, and it is thought | Health and Human Services, Department of / National Institutes of Health | 7/27/2009 |
| CHILDRENS HOSPITAL OF PHILADELPHIA | $1,005,496 | Grant | Trans-NIH Recovery Act Research Support: The long-term objective of our research is to characterize the molecular and genetic role of GCM2 in controlling parathyroid gland development during embryogenesis and parathyroid cell maintenance after birth. Studies in mice have shown that parathyroid f | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO | $897,217 | Grant | Trans-NIH Recovery Act Research Support: There is a very high degree of genetic and physical similarity between humans and the various species of non-human primates and this high degree of similarity can be exploited in medicine to better understand the mechanisms and find new treatments of many | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $949,500 | Grant | Trans-NIH Recovery Act Research Support: This project applies proteomic methodology to analyze peripheral blood samples from patients with hemolytic anemia. Our focus is on evaluation of younger individuals, or those with a family history of anemia, in order to identify novel genetic causes of c | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF WASHINGTON | $1,529,793 | Grant | Trans-NIH Recovery Act Research Support: Chronic pancreatitis, a destructive disease of the pancreas, is difficult to diagnosis and can present with a variety of symptoms. The incidence of chronic pancreatitis is not known; hospital admission and discharge summaries suggest at least 60,000 pati | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| GEORGETOWN UNIVERSITY (THE) | $767,500 | Grant | Trans-NIH Recovery Act Research Support: Aberrant norepinephrine [NE] neurotransmission in the human brain is linked to mood disorders, depression, drug addiction and neurodegenerative diseases. ? -synuclein [? -Syn], a member of the synuclein family of proteins, is expressed in monoaminergic ne | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $648,159 | Grant | Trans-NIH Recovery Act Research Support: This project concerns the physiological mechanisms of brain oscillations in the neocortex, a structure vital for perception, thought and memory. Brain oscillations are believed to be important for sensory processing, cognitive states such as attention, an | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| BOSTON COLLEGE, TRUSTEES OF | $439,613 | Grant | Trans-NIH Recovery Act Research Support: The award is to purchase/upgrade two NMR spectrometers for use in the Chemistry Department at Boston College. To that end we have negotiated with Varian Instruments for a upgrade to an existing 400 MHz spectrometer (all but the magnet is new) and a new 50 | Health and Human Services, Department of / National Institutes of Health | 5/01/2009 |
| THOMAS JEFFERSON UNIVERSITY | $289,520 | Grant | Trans-NIH Recovery Act Research Support: This application is for support to purchase a Leica AM TIRF (total internal reflection fluorescence) microscope system. The instrument will be housed within the - Facility of the Kimmel Cancer Center of Thomas Jefferson University. This Facility provides | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $498,200 | Grant | Trans-NIH Recovery Act Research Support: Funds are requested to purchase a state of the art console and gradient amplifiers for a small animal magnetic resonance imaging (MRI) and spectroscopy scanner. The new instrumentation will be interfaced to an existing vertical bore 9.4 T, 8.9 cm magnet | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| PURDUE UNIVERSITY | $353,102 | Grant | Trans-NIH Recovery Act Research Support: The Center on Aging and the Life Course at Purdue University seeks support for an interdisciplinary, pre- doctoral research training program. The proposed institutional National Research Service Award (NRSA) is designed to build upon recent institutional | Health and Human Services, Department of / National Institutes of Health | 5/19/2009 |
| KESSLER FOUNDATION INC | $92,512 | Grant | Trans-NIH Recovery Act Research Support: The NIH Roadmap recognizes a pressing need to better quantify clinically important symptoms and outcomes, including pain, fatigue, and quality of life. The NIH Roadmap has lead to an unprecedented number of large-scale initiatives for health-related quali | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| FLORIDA ATLANTIC UNIVERSITY | $213,413 | Grant | Trans-NIH Recovery Act Research Support: Award Title G?? Molecular mechanisms of oxidative stress resistance in an animal model of aging. The effects of reactive species (ROS) and oxidative stress on protein organization, cellular homeostasis, and apoptosis are recognized as key factors in agin | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| BUCKNELL UNIVERSITY | $220,128 | Grant | Trans-NIH Recovery Act Research Support: This project will use preclinical mouse models to test two novel applications of the farnesyl transferase inhibitor class of anti-cancer drugs. The ability of farnesyl transferase inhibitors to improve on existing therapies in Burkitt lymphoma will be exa | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| WINTHROP UNIVERSITY | $239,190 | Grant | Trans-NIH Recovery Act Research Support: In addition to their roles in transcription, growth and proliferation, and retroviral integration, emerging evidence implicates the High Mobility Group A1 (HMGA1) proteins as important mediators in oncogenic transformation. Enforced expression of HMGA1 le | Health and Human Services, Department of / National Institutes of Health | 5/11/2009 |
| SOUTHERN METHODIST UNIVERSITY INC | $218,250 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Many oncogenic viruses interact with cellular oncoproteins to induce cancers in humans. It is of paramount importance to understand the mechanisms by which transforming viruses cooperate with host factors to promote ne | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| GEORGIA HEALTH SCIENCES UNIVERSITY RESEARCH INSTITUTE, INC. | $220,500 | Grant | Trans-NIH Recovery Act Research Support: Sjogren's syndrome (SS) is a complex autoimmune disorder causing dysfunction of the salivary and lacrimal glands, leading to dry mouth and dry eyes. SS is also associated with rheumatic disorders such as rheumatoid arthritis. The cause of SS is unknown an | Health and Human Services, Department of / National Institutes of Health | 8/21/2009 |
| MISSOURI SYSTEM, UNIVERSITY OF | $225,750 | Grant | Trans-NIH Recovery Act Research Support: The biomolecule delivery system established from this project can be a useful research tool for basic biological studies which lead to understanding of the nature of human diseases. This system can be further developed to carry functional diagnostic and t | Health and Human Services, Department of / National Institutes of Health | 7/07/2009 |
| CLEMSON UNIVERSITY | $222,729 | Grant | Trans-NIH Recovery Act Research Support: Creosote is an especially toxic distillate of coal tar containing primarily polycyclic aromatic hydrocarbons (PAHs). Creosote has been used almost exclusively as a means to preserve wood, therefore large scale production has taken place with several insta | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| ST JOHN'S UNIVERSITY, NEW YORK | $245,250 | Grant | Trans-NIH Recovery Act Research Support: Histone acetylation affects chromatin structure an regulates diverse cellular functions, such as gene expression, DNA repair, and cell proliferation. Many histone deacetylase inhibitors reactivate the transcription of multiple genes that are silenced in h | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| DEPAUW UNIVERSITY | $200,291 | Grant | Trans-NIH Recovery Act Research Support: Continual addition of posterior tail segments beyond the embryonic period is a little known and little understood phenomenon. The immediate goal of this research is to investigate tail elongation and regeneration across life stages (embryo, larval, and ad | Health and Human Services, Department of / National Institutes of Health | 8/25/2009 |
| OKLAHOMA STATE UNIVERSITY | $406,175 | Grant | Trans-NIH Recovery Act Research Support: Bronchopulmonary dysplasia (BPD) is a chronic lung disease that develops in preterm neonates treated with oxygen and mechanical ventilation. BPD causes arrested lung development. The pathogenesis of BPD is still not completely understood. A novel pathway | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| OHIO STATE UNIVERSITY, THE | $790,498 | Grant | Trans-NIH Recovery Act Research Support: This project will develop a new generation of paramagnetic, functionally oriented probes for the needs of electron paramagnetic resonance (EPR) spectroscopy and imaging, particularly for in vivo applications. EPR- based techniques are far from attaining t | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $484,000 | Grant | Trans-NIH Recovery Act Research Support: Chronic obstructive Pulmonary Diseases (COPD) are characterized by chronic lung infection and inflammation. The long term objective of this proposal is to identify means to control inflammation and progression in obstructing airways disease. Recent evid | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $785,000 | Grant | Trans-NIH Recovery Act Research Support: The gene in question codes for a protein called ?B1? which in its abnormal state will change the composition in the urine resulting in kidney stone formation. We will use human population and laboratory studies to answer three questions. 1. Exactly how co | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| UNIVERSITY OF FLORIDA | $660,000 | Grant | Trans-NIH Recovery Act Research Support: Hyperoxaluria is considered to be a major risk factor in calcium oxalate stone disease which occurs in about 12% of the American population and, apart from reducing dietary sources of oxalate, there is currently no pharmacological treatment available. Mo | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| CHILDRENS HOSPITAL OF PHILADELPHIA | $650,000 | Grant | Trans-NIH Recovery Act Research Support: In response to partial outlet obstruction, the urinary bladder is capable of undergoing hypertrophy via a complex remodeling process that allows it to adapt to its new workload. This remodeling is driven by a number of signaling cascades and their corresp | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $4,254,196 | Grant | Trans-NIH Recovery Act Research Support: It is estimated that 3.2 million African Americans aged 20 years or older have T2DM. This represents approximately 13 percent of the AA population and a significant proportion of the more than 20 million Americans believed to be living with diabetes, a di | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| UNIVERSITY OF WASHINGTON | $915,340 | Grant | Trans-NIH Recovery Act Research Support: The scanning fiber endoscope is an ultrathin and flexible scope that provides high-resolution by scanning low-power laser light. By integrating higher-power laser light, early cancers and neoplasia can be imaged and treated with oncologic laser therapies | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $1,140,410 | Grant | Trans-NIH Recovery Act Research Support: Epidemiologic studies have demonstrated that exposure to tobacco products is an important risk factor in the progression of chronic kidney disease (CKD). Among the numerous harmful substances found in tobacco, nicotine is one of the highly active compound | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| DUKE UNIVERSITY | $753,280 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this proposal is to understand how ectopic signaling through the acetylcholine pathway results in changes that eventually influence adult learning and behavior. This will involve looking at the influences of exciting acetylcholine activate | Health and Human Services, Department of / National Institutes of Health | 9/20/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $811,250 | Grant | Trans-NIH Recovery Act Research Support: To understand the function of organophosphates and interrelationship between environmental toxins and paraoxonase in oxidative stress and inflammation associated with Alzheimer's disease. The long-term goal of this project is to understand the role of en | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $1,003,311 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this project is to assess whether exposure to metabolites of endocrine disrupting compounds during pregnancy is associated with a) adverse development (cognitive function, height, weight, weight for height, and for females, age at mena | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $1,246,800 | Grant | Trans-NIH Recovery Act Research Support: Efficient visual recognition is critical for many aspects of our lives, and understanding how il is accomplished is essential for any complete theory of the brain. One primary reason for the efficiency of object recognition is its facilitation by top-down | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $147,016 | Grant | Trans-NIH Recovery Act Research Support: Fulfilling ARRA goals we recruit two scientists to boost University of Alabama at Birmingham important health related research and to make a positive impact on the local economy. Hiring two senior scientists in order to boost our research to achive specif | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $559,500 | Grant | Trans-NIH Recovery Act Research Support: Bacterial polysaccharides are traditionally viewed as molecules that do not form stable secondary structure and are unable to elicit a protective T lymphocyte-driven immune response. We have recently discovered that one class of polysaccharide not only ac | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| WILLIAM MARSH RICE UNIVERSITY | $457,500 | Grant | Trans-NIH Recovery Act Research Support: Coupled electron and proton transfer is recognized as the universal principle of primary energy conservation in respiration. Terminal respiratory oxidases are membrane-bound electron- transfer complexes that catalyze the reduction of oxygen to water and t | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| WASHINGTON UNIVERSITY, THE | $547,200 | Grant | Trans-NIH Recovery Act Research Support: Identification of even a single gene that contributes to a complex trait provides insight into its molecular basis. However, multiple genes need to be identified if different genes affect a trait through different biological processes or pathways. In the | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $755,320 | Grant | Trans-NIH Recovery Act Research Support: This project will focus on the discovery of compounds that act as potent Inhibitors of each of the six ATPases In the proteasome. These proteins use the energy of ATP hydrolysis to unfold proteins destined for degradation by the proteasome and feed them I | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| DUKE UNIVERSITY | $643,208 | Grant | Trans-NIH Recovery Act Research Support: The regulatory nature and physical structure of chromatin are dynamically regulated by post- translational modifications of core histone proteins. The recent discovery of histone demethylases has initiated a rapid increase in our knowledge about the regul | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| UNIVERSITY OF MASSACHUSETTS | $631,198 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this proposal is to examine the role of internal Ca2+ stores in neurohypophyseal nerve terminals of magnocellular hypothalamic neurons found in the posterior pituitary. These terminals secrete Oxytocin or Arginine Vasopressin, which have w | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| THE VANDERBILT UNIVERSITY | $682,503 | Grant | Trans-NIH Recovery Act Research Support: The broad goal of the proposed research is to extend our understanding of the functions of the cyclooxygenase enzymes (COXs, prostaglandin H synthases). These enzymes participate importantly in many physiologic functions and diseases, including key partic | Health and Human Services, Department of / National Institutes of Health | 9/08/2009 |
| WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION | $586,000 | Grant | Trans-NIH Recovery Act Research Support: This project is aimed at expanding our de novo synthesis methodology towards the development of new methods for medicinal chemistry SAR- studies. These methods will be applied toward the studies of three classes of anticancer natural products: Digit | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| DUKE UNIVERSITY | $647,400 | Grant | Trans-NIH Recovery Act Research Support: DNA mismatch repair (MMR) is a major contributor to genome stability. MMR corrects DNA biosynthetic errors, ensures the fidelity of genetic recombination and is required for the cellular response to certain classes of DNA damage, including lesions induced | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| ROCKEFELLER UNIVERSITY FACULTY AND STUDENTS CLUB INC, THE | $844,791 | Grant | Trans-NIH Recovery Act Research Support: Our long-term aim is to understand how sensory organs form. Sensory structures allow organisms to assess their environment, and sensory organ defects in humans lead to perceptive and psychological deficits. Lumen formation plays key roles in sensory organ | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| DUKE UNIVERSITY | $916,378 | Grant | Trans-NIH Recovery Act Research Support: Newborn screening with tandem mass spectrometry (MS/MS) has been expanded to detect a number of inherited disorders of metabolism, including lysosomal storage disorders. MS/MS allows the pre-symptomatic detection and early treatment of infants with inheri | Health and Human Services, Department of / National Institutes of Health | 8/07/2009 |
| UNIVERSITY OF MIAMI | $688,500 | Grant | Trans-NIH Recovery Act Research Support: The effects of yoga on prenatally depressed women will be tested in this study. Yoga would be expected to reduce depression, enhance vagal activity, reduce cortisol and increase gestational age (reduce premature deliveries) in depressed women. The women | Health and Human Services, Department of / National Institutes of Health | 7/28/2009 |
| UNIVERSITY OF MARYLAND | $2,010,457 | Grant | Trans-NIH Recovery Act Research Support: Overweight is a serious public health problem that begins as early as toddlerhood, and has negative health and developmental consequences throughout life. Although caregiver-child interaction patterns influence children's growth, most overweight preventio | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $775,527 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of the proposed research is to understand the complex genetic control of determination of left/right (L/R) body axis in the mammalian embryo. Specification of the L/R axis sets up a developmental cascade that coordinates development of | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $1,552,953 | Grant | Trans-NIH Recovery Act Research Support: In addition to the increase in obesity in adult and children, there has been a significant increase in birth weights over the last 2 decades. Based on our preliminary data, maternal pregravid obesity is the strongest risk factor for neonatal as well as a | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $686,204 | Grant | Trans-NIH Recovery Act Research Support: According to The World Health Organization, iron deficiency is the foremost nutritional disorder in the world. Iron is essential for normal neurological function and iron deficiency results in cognitive and motor impairments that can last throughout life, | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $1,239,179 | Grant | Trans-NIH Recovery Act Research Support: The project titled G?A longitudinal MRI study of brain development in Fragile X syndromeG? aims to study very early brain and behavior development at 6, 12 and 24 months in infants with fragile X syndrome (FXS). Investigators use Magnetic Resonance Imag | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF MIAMI | $1,012,474 | Grant | Trans-NIH Recovery Act Research Support: This project will take advantage of the existing infrastructure of the PHACS Study which began protocol development in 2005 after successfully competing for funding by the NICHD. This is a multicenter, multidisciplinary and collaborative study. The PHACS | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF WASHINGTON | $2,623,078 | Grant | Trans-NIH Recovery Act Research Support: This proposal will explore the hypothesis that autism is caused by highly-penetrant, rare mutations using emerging technologies that screen regions for autism-specific CNV mutations and exonic point mutations. Our targeted focus will be 17 genomic region | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |