Listing all stimulus spending by amount, in descending order. Return to National Institutes of Health page
Amount refers to both the amount of stimulus funding going toward the project and the face value of the loan.
| Recipient | Amount | Type | Description | Federal Dept./Agency | Date |
|---|---|---|---|---|---|
| CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | $160,519 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The primary goal of this research is to understand communication, comprehension and decision-making in Phase I childhood cancer trials. The project will take place at 6 of the most active Phase I pediatric programs in | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $286,422 | Grant | Trans-NIH Recovery Act Research Support: The combined use of TLR and CD40 agonists together with tumor antigen is a novel vaccine platform that elicits robust immunity resulting in the effective eradication of pre-existing cancer. The synergy that is manifested by the combined administration of | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| UNIVERSITY OF CHICAGO, THE | $98,000 | Grant | Trans-NIH Recovery Act Research Support: Receptor tyrosine kinases (RTKs) have been shown to be important as therapeutic targets againstlung cancer. However, even with the RTK epidermal growth factor receptor inhibition, the responsewith small molecule inhibitors is at best 5%-15% in refractory | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| THE VANDERBILT UNIVERSITY | $326,312 | Grant | Trans-NIH Recovery Act Research Support: This grant has enabled the creation of software that contributes important capabilities for identifying mutated and modified proteins that are characteristic of cancer samples. This supplement will hire a new programmer tasked with adding three new featur | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $264,045 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Despite impressive advances in understanding cancer etiology and the development of novel therapeutic approaches, the most effective therapies for solid malignancies (carcinomas) remain surgery and radiotherapy. Althou | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF MASSACHUSETTS | $317,255 | Grant | Trans-NIH Recovery Act Research Support: We submitted this administrative supplement in response to the request for administrative supplements through the American Recovery and Reinvestment Act (ARRA). With the funds we are:1. Accelerating science by adding comparative effectiveness implementa | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $344,669 | Grant | Trans-NIH Recovery Act Research Support: The parent grant (R01 CA129484) entitled A Cellular and Molecular Analysis of the Intravasation Step in Tumor Metastasis was dedicated to investigating the overall process of intravasation, the entry of primary tumor cells into the vasculature of the host | Health and Human Services, Department of / National Institutes of Health | 9/02/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $50,410 | Grant | Trans-NIH Recovery Act Research Support: Current diagnostic tests cannot reliably determine prostate cancer extent (volume and location) or biological aggressiveness. Our long term goal is to develop a non-invasive imaging technique that accurately assesses the clinical significance of prostate | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $0 | Grant | Trans-NIH Recovery Act Research Support: The goal of our studies is to develop a quantitative understanding of tumor metastasis. As cell migration is the central part of metastasis, we are developing quantitative experimental and computational methods to study migration in three dimensional matr | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| METHODIST HOSPITAL RESEARCH INSTITUTE, THE | $18,240 | Grant | Trans-NIH Recovery Act Research Support: The goal of this summer program is to offer an intensive laboratory experience for an undergraduate student, and to speed up our research progress in developing nanomedicine. Ms. Catherine Chen, a sophomore major in chemistry from Rice University has work | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| TORREY PINES INSTITUTE FOR MOLECULAR STUDIES, INC. | $313,200 | Grant | Trans-NIH Recovery Act Research Support: This study develops novel approaches based on the p14ARF tumor suppressor and Spermidine-CoA-based inhibitors of histone acetylation to improve cellular responses to topoisomerase I-targeted chemotherapies and reverse therapy resistance, a major obstacle | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $535,374 | Grant | Trans-NIH Recovery Act Research Support: It has been suggested that the small fraction of tumor cells capable of initiating local or distant recurrence exhibit properties of stem cells, and that identification and molecular characterization of putative cancer stem cells will lead to better outco | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $18,367 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Proteolytic processing of proenkephalin (PE) is required to produce active enkephalin opioid peptides that regulate analgesia, behavior, and immune cell function. It is, therefore, critical to define the multi-step pro | Health and Human Services, Department of / National Institutes of Health | 6/19/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $61,020 | Grant | Trans-NIH Recovery Act Research Support: Priming is a class of ubiquitous behavioral phenomena defined as progressive increase in the speed and strength of behavioral responses to repeated stimuli. Priming has a clear mnemonic component, i.e., responses remain potentiated for a considerable per | Health and Human Services, Department of / National Institutes of Health | 6/19/2009 |
| WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION | $41,900 | Grant | Trans-NIH Recovery Act Research Support: Cocaine and methamphetamine are leading drug threats in the U.S. today, yet no effective treatments for their abuse are available. Parent grant information: The specific aims of the parent grant tests the hypothesis that beta receptors represent viable m | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| DUKE UNIVERSITY | $17,622 | Grant | Trans-NIH Recovery Act Research Support: Drugs of abuse induce persistent adaptations in neuronal function that are driven in part by the drug-induced expression of new gene products which modulate synaptic function and neuronal excitability. My laboratory has been studying the role of epigeneti | Health and Human Services, Department of / National Institutes of Health | 6/19/2009 |
| UNIVERSITY OF MARYLAND | $37,818 | Grant | Trans-NIH Recovery Act Research Support: This proposal examines the processing and encoding of temporal information in a relatively well understood auditory system. Analysis of how animals process temporal information has uncovered many common principles: Despite their different neural substrate | Health and Human Services, Department of / National Institutes of Health | 8/12/2009 |
| MONELL CHEMICAL SENSES CENTER | $302,315 | Grant | Trans-NIH Recovery Act Research Support: The sense of taste is the primary sensory system that determines whether a food or beverage will be ingested or rejected. Taste also influences food processing by the digestive system. Consequently, understanding the mechanisms underlying this sense is ce | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| NORTHEASTERN OHIO UNIVERSITY COLLEGE OF MEDICINE | $26,057 | Grant | Trans-NIH Recovery Act Research Support: This grant provided summer research experiences for 2 undergraduate college students in health-related scientific research. | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| MONELL CHEMICAL SENSES CENTER | $161,089 | Grant | Trans-NIH Recovery Act Research Support: Odor information is encoded by selective activation of olfactory receptors and mapped topographically to glomeruli in the olfactory bulb. Our broad, long term objective is to understand dendritic and synaptic signaling mechanisms in the bulb that transfor | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| MONELL CHEMICAL SENSES CENTER | $300,047 | Grant | Trans-NIH Recovery Act Research Support: Odor information is encoded by selective activation of olfactory receptors and mapped topographically to glomeruli in the olfactory bulb. Our broad, long term objective is to understand dendritic and synaptic signaling mechanisms in the bulb that transfor | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| UNIVERSITY OF ARIZONA | $91,342 | Grant | Trans-NIH Recovery Act Research Support: Almost all organisms that possess an olfactory system exhibit a similar organization in their primary olfactory neuropil. Olfactory receptor neurons (ORNs) that detect volatile molecules in the periphery extend axons into the brain where they form networ | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| NORTHWESTERN UNIVERSITY | $200,199 | Grant | Trans-NIH Recovery Act Research Support: Human adults can improve their auditory perceptual skills through practice, making perceptual training a promising tool to treat communication disorders. However, the perceptual-training regimens currently used are costly in time, as well as in financial | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| MICHIGAN STATE UNIVERSITY | $170,052 | Grant | Trans-NIH Recovery Act Research Support: Twenty-eight million Americans suffer from hearing impairment. By age 80 about half the population has age-related hearing loss (presbycusis). While some degree of presbycusis can be ascribed to environmental exposures, a significant fraction is genetical | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $111,220 | Grant | Trans-NIH Recovery Act Research Support: The long term goal of our research is to develop an acoustically-based, explanatory model of the communication deficit in dysarthria that can be used to guide and justify treatment decisions. Toward this end, the proposed Phase I treatment project will in | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| UNIVERSITY OF MARYLAND | $151,911 | Grant | Trans-NIH Recovery Act Research Support: Many early-implanted children with cochlear implants (CIs) today attend mainstream schools alongside their NH peers.At present, information about how young, NH children process sounds at a psychophysical level is relatively sparse in the field. Even less | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY | $92,745 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Gravity is an important context for adapting the angular vestibulo-ocular reflex (aVOR) by visual-vestibular mismatch. Maximal gain changes occur in the position of adaptation and decrease, as the head is oriented away | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| COLD SPRING HARBOR LABORATORY ASSOCIATION, INC. | $183,253 | Grant | Trans-NIH Recovery Act Research Support: The nervous system processes sensory stmuli, such as sounds, by encoding them into a sequence of neural representation (deCharms and Zador 2000). The cortical representation is a highly processed version of the auditory nerve input from which it was deri | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $99,739 | Grant | Trans-NIH Recovery Act Research Support: Research Equipment for the Advancement of Science: This supplement grant is to purchase equipment that will significantly increase our capacities to pursue the research aims of the parent application R01-DC005808 ('Auditory-Vocal Interaction Mechanisms'). | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $175,500 | Grant | Trans-NIH Recovery Act Research Support: Vestibular schwannomas in humans can cause morbidity associated with hearing and balance loss, facial paralysis and paresthesias, and occasionally life-threatening brainstem compression. Vestibular schwannomas can be divided into three general categories | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $174,250 | Grant | Trans-NIH Recovery Act Research Support: Afferent Synaptic Transmission in the Mammalian Cochlea: Parent Grant: This proposal seeks to investigate mechanisms of synaptic transmission at the inner hair cell (IHC) afferent synapse in the mammalian cochlea. In the inner ear, sound signals are conve | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC. | $97,050 | Grant | Trans-NIH Recovery Act Research Support: Cellular therapy for the inner earThese purchases will permit us to collect more data and will increase the efficiency of our work. The real time analysis of neural growth will speed up our testing of individual genes that will be assessed for the regrowt | Health and Human Services, Department of / National Institutes of Health | 6/30/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $170,492 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Lateral olivocochlear (LOG) efferent endings on Type I auditory nerve (AN) peripheral processes are strategically placed to provide a powerful and dynamic regulation of AN activity. We have developed methods to lesion | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $207,383 | Grant | Trans-NIH Recovery Act Research Support: The remarkable sensitivity and specificity of mammalian olfaction arises from the contributions at the molecular, cellular and tissue levels to establish a sensory organ. One of the most important components in this developmental process is the olfactory | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC. | $202,460 | Grant | Trans-NIH Recovery Act Research Support: 'Basic and Clinical Studies of Noise-Induced and Age-Related Hearing Loss' Our goal is to understand how these structures are cycled in normal ears and whether they are replaced or regenerated after acoustic trauma. Such work should improve our understan | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $40,040 | Grant | Trans-NIH Recovery Act Research Support: The long term goals of our laboratory are to understand the molecular mechanisms responsible for cell fate specification and sensory patch formation in the developing mammalian inner ear. Progress toward understanding these essential aspects of inner ear | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| BAYLOR COLLEGE OF MEDICINE | $186,555 | Grant | Trans-NIH Recovery Act Research Support: This project will accelerate the progress of the funded research, increase the focus on a common vistibular disorder, increase the statistical power for some experiements of the parent grant for some experiments, ask a clinical question that may increase | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $279,110 | Grant | Trans-NIH Recovery Act Research Support: Abstract Bilateral loss of vestibular function (inner ear balance sensation) due to ototoxic hair cell injury is disabling, with patients suffering disequilibrium and inability to maintain stable vision during head movements typical of daily life. While m | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF TEXAS HEALTHCARE AT TYLER | $693,110 | Grant | Trans-NIH Recovery Act Research Support: Infections due to Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, are the leading causes of morbidity and mortality in both HIV infected and immune competent people. A major factor contributing to virulence of Mtb is its intrinsic s | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| TUFTS MEDICAL CENTER, INC. | $1,431,873 | Grant | Trans-NIH Recovery Act Research Support: Despite the advent of new G?targetedG? drugs for the treatment of blood cancer 'leukemia'), many patients will fail therapy and relapse. The goals of this proposal are to develop and test new leukemia therapies, based on transfusion of cells from the blo | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| UMDNJ-ROBERT WOOD JOHNSON MEDICAL SCHOOL | $156,000 | Grant | Trans-NIH Recovery Act Research Support: This proposal is submitted in response to the announcement ?NIH Small grant Program (RO3)-PA-06-180?. The goal of this proposal is to understand the role of transcription antitermination and melting of nucleic acid secondary structures in bacterial adapta | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| WRIGHT STATE UNIVERSITY | $718,089 | Grant | Trans-NIH Recovery Act Research Support: This funding will enable the Principal Investigator and other SOM faculty to acquire a Multi-Photon Microscope in order to facilitate neuroscience research through the Imaging Core Facility at WSU. The system is built from components from different sourc | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $1,324,730 | Grant | Trans-NIH Recovery Act Research Support: Purchase of a 700MHz NMR Spectrometer for Liquid Applications Project Summary Solution nuclear magnetic resonance (NMR) spectroscopy is one of the most powerful spectroscopic tools available to the synthetic chemist for the elucidation of the structure of | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| WAKE FOREST UNIVERSITY | $2,000,000 | Grant | Trans-NIH Recovery Act Research Support: New Cyclotron for Translational PET Imaging Project Summary: We herein request for a replacement Cyclotron for the Center for Biomolecular Imaging (CBI) program at WFUHS. The CBI is a centralized imaging resource at our institution that supports the tran | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| UNIVERSITY OF FLORIDA | $326,049 | Grant | Trans-NIH Recovery Act Research Support: Title: Establishment of a High performance UPLC-QSTAR Elite Proteomics Platform at University of Florida. This project is to establish an UPLC-QSTAR Elite Proteomics Platform at University of Florida to enhance the mass spectrometry technology infrastruct | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| UNIVERSITY OF IOWA, THE | $500,000 | Grant | Trans-NIH Recovery Act Research Support: The Zeiss LSM 710 Laser Scanning Confocal Microscope will be a critical tool for NIH investigators at the University of Iowa. The proposed microscope will replace a failing system that over the past 18 months has supported the confocal imaging needs of 55 | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $500,000 | Grant | Trans-NIH Recovery Act Research Support: The objective of this NCRR Shared Instrument Grant application is to obtain funding to purchase a Thermo Electron Orbitrap XL-ETD mass spectrometer for the W.M. Keck Biomedical Mass Spectrometry Lab (MS Core) at the University of Virginia's School of Medi | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| UNIVERSITY OF WASHINGTON | $383,171 | Grant | Trans-NIH Recovery Act Research Support: Obesity and diabetes are complex disorders that have emerged as major health concerns worldwide. The complexity inherent in these disorders with respect both to their pathogenesis and metabolic consequences has heightened the need for interactive groups | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| UNIVERSITY OF NEW MEXICO | $312,322 | Grant | Trans-NIH Recovery Act Research Support: Design-based stereology has become the required method for insuring that cell number and volume estimates in brain (and other) tissue sections are unbiased. Expressed user need underlies this proposal to purchase an integrated confocal stereology system f | Health and Human Services, Department of / National Institutes of Health | 5/01/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $449,189 | Grant | Trans-NIH Recovery Act Research Support: Confocal Laser Scanning Microscope LSM 710 #5- ARRA This was a grant to purchase a greatly needed confocal laser scanning microscope(CLSM) for use in a microscopy core facility that provides service to hundreds of scientist on the medical campus. The CLS | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $500,000 | Grant | Trans-NIH Recovery Act Research Support: Funding support is requested for a MALDI-TOF-TOF mass spectrometer with associated liquid chromatograph and spotting robot that are essential to many NIH-funded research programs. To ensure maximum availability, proper maintenance and best use of NIH fund | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| UNIVERSITY OF SOUTH FLORIDA | $221,200 | Grant | Trans-NIH Recovery Act Research Support: This proposal requests funds to purchase a NanoZoomer Digital Pathology System for the use of 9 investigators at the University of south Florida in Tampa. The NanoZoomer was selectedowing to it's a) capacity to collect images using fluorescence as well a | Health and Human Services, Department of / National Institutes of Health | 4/27/2009 |
| ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE | $887,796 | Grant | Trans-NIH Recovery Act Research Support: The viral hemorrhagic fevers (VHFs) pose a threat as possible bioterrorist agents as well as to populations in sub-Saharan Africa where many VHFs are endemic. The non-specific clinical presentation of the VHF, makes them extremely difficult to diagnose cl | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| NEW YORK UNIVERSITY (INC) | $701,437 | Grant | Trans-NIH Recovery Act Research Support: In nature, cytotoxic T-cells are responsible for identifying cells that display foreign antigens and killing them. However, T-cells do not only respond fully to typical foreign antigens but also show responses to self in the periphery in the form of co-ag | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| J CRAIG VENTER INSTITUTE INC | $8,766,536 | Grant | Trans-NIH Recovery Act Research Support: Human physiology and health is highly dependent on the activities of billions of microorganisms that inhabit multiple niches within and on the human body. Few of these microorganisms have been characterized, in large part because the majority is yet to be | Health and Human Services, Department of / National Institutes of Health | 5/22/2009 |
| H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC. | $3,717,440 | Grant | Trans-NIH Recovery Act Research Support: We propose that Cancer is a dynamic complex multiscale system that can only truly be understood via the integration of theory and experiments. The goal of the proposal is to use such an integrated approach to better understand, predict and treat cancer. | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| TRUDEAU INSTITUTE, INC. | $5,009,999 | Grant | Trans-NIH Recovery Act Research Support: Infectious diseases, such as influenza, lead to high morbidity and mortality in elderly populations. In addition, the efficacy of vaccines is also significantly reduced for elderly populations, leaving them much more vulnerable to infection. We have devel | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF TENNESSEE | $739,583 | Grant | Trans-NIH Recovery Act Research Support: C. albicans is an opportunistic human fungal pathogen that causes mucosal, cutaneous, and systemic infections including oropharyngeal candidiasis (OPC), the most frequent opportunistic infection among patients suffering from AIDS. Fluconazole and other az | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| YALE UNIVERSITY | $963,898 | Grant | Trans-NIH Recovery Act Research Support: Neurological recovery is limited in many clinical situations by the inability of adult brain and spinal cord to grow axons and form new connections to replace lost function. This Project seeks to define the molecular limitations on nerve fiber growth in t | Health and Human Services, Department of / National Institutes of Health | 7/19/2009 |
| BAYLOR COLLEGE OF MEDICINE | $840,933 | Grant | Trans-NIH Recovery Act Research Support: Statement of Purpose: Identifying novel mechanisms of cell death regulation for stroke, heart disease and cancer | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| UNIVERSITY OF LOUISVILLE | $370,000 | Grant | Trans-NIH Recovery Act Research Support: This research project pursues the hypothesis that the fatty acid-binding proteins, A-FABP and E-FABP, link metabolic and inflammatory pathways in leukocytes and act as regulators of both innate and adaptive immune responses. Specific Aim 1 is to identify | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $308,407 | Grant | Trans-NIH Recovery Act Research Support: Conditions have been optimized for conducting chromatin immunoprecipitation assays with low background and sufficient resolution to give clear signals after ChIP-Seq analysis. We anticipate commencing ChIP-Seq analysis of osteoblast differentiation in the | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF ROCHESTER | $186,806 | Grant | Trans-NIH Recovery Act Research Support: The supplement will provide funding for a post doctoral scientist to work on the project at the sub-award institution. The pace of research will be accelerated by this hire. A key event in the secretagogue stimulation of both the fluid and protein compo | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF NEW MEXICO | $30,000 | Grant | Trans-NIH Recovery Act Research Support: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is caused by mutations in the genes encoding polycystin-1 and/or polycystin-2, but results in epithelial cells with disrupted adherensjunctions and compromised beta-catenin signaling pathways. Our data | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $77,977 | Grant | Trans-NIH Recovery Act Research Support: The colonic epithelium is subjected to a variety of challenges that result in a wide range of diseases and disorders, including colitis, polyp formation and malignant transformation. We have identified the Let 7a3 and Let 7b microRNAs, which are critical | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $10,704 | Grant | Trans-NIH Recovery Act Research Support: There were two supplements for this award. The first was to support the addition of an undergraduate student during the past summer. The student was hired and worked effectively on this program. The student's work focused on processing brains from develop | Health and Human Services, Department of / National Institutes of Health | 7/29/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $99,982 | Grant | Trans-NIH Recovery Act Research Support: This supplement allows for characterization at a cellular level the events leading to the early increases in matrix stiffness that precede fibrosis; specifically to determine which cells in the liver secrete collagen and elastin immediately after injury; | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| MONTEFIORE MEDICAL CENTER | $50,000 | Grant | Trans-NIH Recovery Act Research Support: The short chain fatty acid butyrate (NaB), present in high concentrations in the colonic lumen principally from the fermentation of dietary fiber, plays a physiological role in colonic homeostasis. This involves maintaining an equilibrium not only between | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $99,993 | Grant | Trans-NIH Recovery Act Research Support: Currently there is a major need in hematopoietic stem cell (HSC) transplantation to develop reduced intensity regimens that do not cause DNA damage and associated toxicities and that allow a wider range of patients to receive therapy. Cytokine receptor s | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $100,068 | Grant | Trans-NIH Recovery Act Research Support: Orthotopic liver transplantation (OLT) is a highly successful therapeutic modality for the treatment of both acute and chronic liver failure which is severely limited by the scarcity of donor livers. Among the livers donated after brain death, the most co | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| EMORY UNIVERSITY | $81,355 | Grant | Trans-NIH Recovery Act Research Support: The Na+/H+ exchanger isoform 3 (NHE3) constitutes a major Na+ transport process, which moves a large quantity of salt and water from the mucosal side toward the serosal side. Our long-term goal is to understand the molecular mechanisms that control NHE3 a | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $100,000 | Grant | Trans-NIH Recovery Act Research Support: This research will advance new concepts in physiological and clinical translational research related to gastrointestinal motility disorders including diabetic gastroparesis. These concepts resulted from biochemical and physiological experiment dealing wit | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| BAYLOR COLLEGE OF MEDICINE | $48,997 | Grant | Trans-NIH Recovery Act Research Support: Training of summer students for biomedical research. Protein biosynthetic quality control systems orchestrate the elimination of newly synthesized proteins that fail to achieve their correct native structure. Our goal is to elucidate how these systems ar | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| CHILDREN'S RESEARCH INSTITUTE | $558,800 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to produce a murine model for neonatal onset N-acetyl-L-glutamate synthase (NAGS) deficiency by creating a mouse in which the NAGS gene has been disrupted. Defects in urea cycle genes such as NAGS affect approximately one in 16 | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $74,365 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The small intestinal epithelium is organized into flask-like glands (crypts) that contain intestinal stem cells and finger-like projections (villi) covered by differentiated cells. A constant process of cell division, | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| UNIVERSITY OF CINCINNATI | $100,915 | Grant | Trans-NIH Recovery Act Research Support: Social stress is prevalent in many facets of modern society. Epidemiological data suggest that stress is linked to the development of overweight, obesity and metabolic disease. We have established the visible burrow system (VBS) model of chronic social st | Health and Human Services, Department of / National Institutes of Health | 7/31/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $99,999 | Grant | Trans-NIH Recovery Act Research Support: Antimitochondrial antibodies (AMA) are unique among autoimmune serologic reactants because of their extremely high association with primary biliary cirrhosis (PBC). The AMA is not only highly directed, but also very specific to the lipoyl domain of PDC-E2 | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $78,643 | Grant | Trans-NIH Recovery Act Research Support: The University of Alabama at Birmingham (UAB) is Alabamas largest employer, with more than 18,000 faculty and staff at the university and in the health system, and is responsible for 52,900 full-time equivalent jobs within the university and the communit | Health and Human Services, Department of / National Institutes of Health | 7/29/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $51,916 | Grant | Trans-NIH Recovery Act Research Support: Autosomal dominant polycystic kidney disease (ADPKD), affecting 500,000 Americans, is the most common potentially lethal genetic disease and is characterized by cyst overgrowth that destroys the kidney. Protein synthesis and delivery are essential to the | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF PITTSBURGH THE | $109,486 | Grant | Trans-NIH Recovery Act Research Support: The focus of the proposed studies is to examine the interaction and modulatory activity of EBP50 on all aspects of PTH1R cycling. To the best of our knowledge, we are the only laboratory comprehensively analyzing the regulatory effects of EBP50 on PTH1R c | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $95,830 | Grant | Trans-NIH Recovery Act Research Support: This proposal will explore genetic pathways that specify the commitment of embryonic mesoderm toward hematopoietic fate in model organisms like the fish and mouse, in order to identify mechanisms that can be engineered to drive hematopoietic stem cell dif | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| UNIVERSITY OF TOLEDO, THE | $58,425 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Steroid receptors (SRs) are hormone-activated transcription factors controlling tissues-specific gene expression and therapeutically important physiologies. In their inactive states, these receptors are known to form c | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| THE VANDERBILT UNIVERSITY | $600,119 | Grant | Trans-NIH Recovery Act Research Support: Gastric cancer develops from preneoplastic metaplsias. Our present grant is focused on identifying and the mechanisms responsible for induction of metaplasia and characterizing possible markers of induced metaplasia in mouse models of acute and chronic pa | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF IOWA, THE | $100,001 | Grant | Trans-NIH Recovery Act Research Support: Gallstone pancreatitis is common and is potentially fatal. Enteral exclusion of bile-pancreatic juice by the stone causes feedback hyperstimulation of the exocrine pancreas that induces pancreatic overproduction of acute inflammatory mediators. Systemic s | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) | $62,279 | Grant | Trans-NIH Recovery Act Research Support: Since the initial description of the free radical theory of aging, the implication has been reactive oxygen species (ROS) generated during normal and abnormal oxidative metabolism, drive the aging process. The exponential increase in intracellular ROS pro | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL | $99,389 | Grant | Trans-NIH Recovery Act Research Support: This supplement to an exisiting NIH-NIDDK R01 grant (DK-075533) is to accelerate the pace of research on the parent grant via enabling the hiring of a post-doctoral fellow for a period of two years. Hiring a post-doctoral fellow will also fulfill the pur | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $110,890 | Grant | Trans-NIH Recovery Act Research Support: The project (ROI DK075718) is designed to evaluate the role of innate immunity in renal ischemia reperfusion injury and is focused primarily on the role of innate immune activation in acute kidney injury. Three aims were proposed in the original grant to | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| PURDUE UNIVERSITY | $100,000 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Despite recent advances in our knowledge of the neural, metabolic and genetic controls of food intake and body weight regulation, the causes of obesity remain elusive and compelling explanations about how changes in bo | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE | $125,895 | Grant | Trans-NIH Recovery Act Research Support: Although Celiac Disease is a well understood form of gluten sensitivity, it can be ruled out in the cases of many gluten-sensitive individuals due to the absence of celiac-specific markers (most notably HLA-DQ2/DQ8 and villus atrophy). The pathogenesis of | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE, INC. | $81,636 | Grant | Trans-NIH Recovery Act Research Support: The majority of the parent grant and its successful continuation rely on using confocal microscopy, which is essential for achieving the goals of the project. However, the manufacturer of the 9-year-old LSM 510 microscope, Carl Zeiss MicroImaging, Inc., w | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $154,704 | Grant | Trans-NIH Recovery Act Research Support: The purpose of the award is to investigate potential changes in glycosaminoglycan sulfation in a podocyte-specific knockout of the glycosaminglycan processing enzyme, NDST1 (N-deactylase, N-sulfotransferase1). Althought he effects of NDST1 knockout has b | Health and Human Services, Department of / National Institutes of Health | 8/29/2009 |
| MAYO CLINIC | $100,783 | Grant | Trans-NIH Recovery Act Research Support: The underlying genetic factors that influence determinants of urinary SS, such as calcium excretion, are poorly defined. This project addresses these gaps in knowledge by identifying genetic associations with urinary lithogenic factors. To do so we have a | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF PITTSBURGH THE | $198,774 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this application is to request funds for a Recovery Act Administrative Supplement to increase the tempo of scientific research of NIH Grant R-01 DK078500, A New Dimension in Renal Clearance Design Criteria for Dendrimer Nanostructures, | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE OF | $16,103 | Grant | Trans-NIH Recovery Act Research Support: Tubulointerstitial renal disease is an important component of the pathobiology of HIV-associated nephropathy (HIVAN), the most common cause of chronic renal failure in HIV-infected individuals. In HIVAN, HIV infection of renal tubular epithelial cells (RT | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| UNIVERSITY OF WASHINGTON | $158,490 | Grant | Trans-NIH Recovery Act Research Support: This American Recovery and Reinvestment Act (ARRA) administrative supplement for RO1 DK079745-01 would be used primarily to support the salary of Courtney Rees, a Health Services PhD candidate, a very talented PhD predoctoral student who is interested in | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| DUKE UNIVERSITY | $11,761 | Grant | Trans-NIH Recovery Act Research Support: Primary Hyperoxaluria type I (PH1) is a severe kidney stone disease caused by deficiency of the protein alanine: glyoxylate aminotransferase (AGT). In many patients, deficiency of AGT results from missense mutations that decrease the stability of this enz | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| THE VANDERBILT UNIVERSITY | $92,200 | Grant | Trans-NIH Recovery Act Research Support: The destruction of renal tissue is associated with progressive tubulointerstitial fibrosis, which is a common final pathway in the development of end-stage renal disease. Renal fibrosis is associated with a reduction in tissue oxygen levels, which is thou | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| NEW YORK UNIVERSITY (INC) | $126,304 | Grant | Trans-NIH Recovery Act Research Support: This project is a competing continuation of our project entitled Parallel Magnetic Resonance Imaging: New Techniques and Technologies, which produced many of the key advances in highly accelerated parallel MRI, and demonstrated their use in rapid imaging | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| THE WASHINGTON UNIVERSITY | $86,271 | Grant | Trans-NIH Recovery Act Research Support: The objective of the proposed research is to develop a novel in vivo microscopic imaging technology, confocal photoacoustic microscopy (PAM). PAM can image intact biological tissues at high resolution with optical absorption contrast, which is sensitive t | Health and Human Services, Department of / National Institutes of Health | 7/30/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $34,016 | Grant | Trans-NIH Recovery Act Research Support: Critical sized bone defects caused by injury, disease or congenital malformations, remain a challenging problem in orthopedic medicine. Current options to restore full function to such bone defects are limited due to slow rates of regeneration of native | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $94,948 | Grant | Trans-NIH Recovery Act Research Support: The advent of ultrashort laser light pulses as a laboratory tool provides an opportunity to probe and manipulate anatomy and function in nervous systems. Ultrashort pulses are the essential means to drive the nonlinear absorption of light by biomolecules, | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $12,547 | Grant | Trans-NIH Recovery Act Research Support: Activity #1 - summer intern -03S1: The goal of the summer project was to simulate and visually demonstrate impingement during the planning phase of the hip osteotomy procedure, include the interface as a simulation constraint when optimizing (minimizing) | Health and Human Services, Department of / National Institutes of Health | 5/28/2009 |
| WASHINGTON STATE UNIVERSITY | $35,880 | Grant | Trans-NIH Recovery Act Research Support: Resorbable Calcium Phosphate Ceramics for Bone Graft Abstract Calcium phosphate (CaP) based ceramics are used in hard tissue engineering because of their excellent biocompatibility. There is a need for the development of biodegradable ceramic materials wi | Health and Human Services, Department of / National Institutes of Health | 6/16/2009 |
| MAYO CLINIC | $26,133 | Grant | Trans-NIH Recovery Act Research Support: This grant provided a summer research experience for one summer student in health-related scientific research. | Health and Human Services, Department of / National Institutes of Health | 6/16/2009 |
| METHODIST HOSPITAL RESEARCH INSTITUTE, THE | $165,077 | Grant | Trans-NIH Recovery Act Research Support: Funds from this administrative supplement are being used to support senior postdoctoral fellow Rongmin Xia, as proposed in the supplement application. Dr. Xia has been trained on the use of the ExAblate 2000 (Insightec, Inc.) to conduct and support studi | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF ROCHESTER | $281,831 | Grant | Trans-NIH Recovery Act Research Support: This proposal is testing the hypothesis that adverse developmental outcomes in children are associated with exposure to methyl mercury (MeHg) from consumption of a diet high in fish. Since 1989, the Seychelles Child Development Study (SCDS) has been follo | Health and Human Services, Department of / National Institutes of Health | 9/06/2009 |
| UNIVERSITY OF ROCHESTER | $12,101 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this project is to provide an underdraduate student training opportunity in field of heme metablism and cell signaling. The heme moiety of denatured hemoproteins (heme-proteins) is degraded by HO-1 & HO-2, to CO and biliverdin (BV), an HO | Health and Human Services, Department of / National Institutes of Health | 7/11/2009 |
| THE WASHINGTON UNIVERSITY | $278,884 | Grant | Trans-NIH Recovery Act Research Support: Parkinson Disease (PD) is a common neurodegenerative disease that affects over 1 million people in North America. Although the cause of PD is unknown, environmental factors are suspected in the majority of cases. Preliminary data from our lab demonstrat | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $337,690 | Grant | Trans-NIH Recovery Act Research Support: Ultraviolet (UV) irradiation from the sun is a well-recognized, otent environmental insult, and skin is directly exposed to UV irradiation. Long-term exposure to UV irradiation damages human skin connective tissue and promotes formation of skin cancer, th | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $294,773 | Grant | Trans-NIH Recovery Act Research Support: Children are exposed to a mix of potential neurotoxicants, including metals, via widespread contamination of food, air, soil and, in some settings, water. Exposure to neurotoxicants during early development can be particularly deleterious. Furthermore, th | Health and Human Services, Department of / National Institutes of Health | 9/06/2009 |
| DUKE UNIVERSITY | $7,539 | Grant | Trans-NIH Recovery Act Research Support: Ambient ozone is associated with increased respiratory illness, hospitalizations, and cardiovascular mortality. Because the lung is recurrently exposed to low level ozone, understanding how ozone modifies immune mechanisms is of considerable importance to | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $117,968 | Grant | Trans-NIH Recovery Act Research Support: ?Genetic models of retinal degeneration? The goals of the parent grant are to establish new retinal degeneration models to explore strategies for suppressing retinal cell death. To do so, we are using the fruit fly as an animal model, since many of the pr | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| WAKE FOREST UNIVERSITY | $285,991 | Grant | Trans-NIH Recovery Act Research Support: Decisions about where to look within a typical visual scene are governed by the relative salience of individual stimuli and current behavioral objectives. To date, the majority of studies examining the cognitive control of visual orienting have targeted f | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF HOUSTON SYSTEM | $127,599 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of our research is to elucidate the role(s) of antimicrobial peptides such as defensins at the ocular surface. These peptides are likely to particpate in direct antimircrobial killing, regulation of immune responses and wound healing. T | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $159,251 | Grant | Trans-NIH Recovery Act Research Support: Adenovirus (Ad) mediated gene transfer is a promising technology for the treatment of many genetic disorders of the Central Nervous System (CNS). Many of the drawbacks that exist with first-generation Ad vectors have been resolved through the use of 'gutt | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC. | $143,836 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this supplement project is to expand the scientific activities that were funded in the parent grant (PI: Pasquale, Gene-Environment Interactions in Glaucoma, Grant EY015473). The specific aims of the parent grant were to 1) identify ca | Health and Human Services, Department of / National Institutes of Health | 6/30/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $409,229 | Grant | Trans-NIH Recovery Act Research Support: In this supplemental proposal, we will describe the benefits of our recent advancements that will greatly enhance the studies in our original proposal by pursuing alternative approaches for the addition of chemistry to investigate the involvement of known | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $302,821 | Grant | Trans-NIH Recovery Act Research Support: The objective of our project is to identify genotype-phenotype associations in individuals affected by hereditary optic nerve disorders through integrative systems-biology based approaches and the application of cost-efficient sequencing technologies. We | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| NORTHWESTERN UNIVERSITY | $130,192 | Grant | Trans-NIH Recovery Act Research Support: The ability to coordinate head and eye movements for the retention of clear images on retina is fundamental for vision perception in daily life. Pathological changes to a region of Cerebellum, Flocculus, appear to cause severe deficits in our ability to m | Health and Human Services, Department of / National Institutes of Health | 7/31/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $114,953 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of the 3-years parent R01 grant, which ended Aug 31st, 2009 and currently in a first year unfunded extension , is a better understanding of the neural substrate of primate eye movements in depth, which require unequal rotations of the two | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF MIAMI | $306,000 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement supports our experiments on finding novel cures for retinal disease and is allowing us to increase the pace of our research. The supplement is used to support the salary of a PhD-level scientist and to purchase necessary sup | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| UNIVERSITY OF WASHINGTON | $79,815 | Grant | Trans-NIH Recovery Act Research Support: Photoreceptors are among the most metabolically active cells. They have extraordinarily large mitochondria and consume oxygen at exceptional rates. Energy production by glycolysis and oxidative phosphorylation must keep pace with energy consumption in t | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| DUKE UNIVERSITY | $255,221 | Grant | Trans-NIH Recovery Act Research Support: Myopia and glaucoma are highly prevalent ophthalmic disorders worldwide, and contribute significantly to ocular morbidity. There is substantial evidence that genetic factors play a significant role in the development of non-syndromic myopia and glaucoma. | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $256,544 | Grant | Trans-NIH Recovery Act Research Support: Despite the great effort and resources that visual neuroscientists have dedicated to establishing a model for the organization of the human visual cortex, information on the histological characteristics of cortical areas is very limited. A web-based sea | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | $145,261 | Grant | Trans-NIH Recovery Act Research Support: Advances in computational biophysics depend on the development of accurate effective potentials and powerful sampling methods to traverse the rugged energy landscapes that govern protein folding, stability, and binding. This supplement is focused on deve | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $89,234 | Grant | Trans-NIH Recovery Act Research Support: Project Summary/Abstract How proteins fold, that is attain their three-dimensional structure, is a fundamental biological process with important implications for human health. Misfolded proteins are often toxic, as illustrated by the number of neurodegene | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| DUKE UNIVERSITY | $287,517 | Grant | Trans-NIH Recovery Act Research Support: Drosophila's Dorsal Closure is a model system for cell sheet morphogenesis during development and wound healing. We plan to investigate the molecular, cellular, and emergent properties that drive morphogenesis during closure using biophysical (laser micro | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $58,721 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this research is to understand the mechanisms eukaryotic cells use to regulate the assembly of cilia and flagella. The flagella of Chlamydomonas are maintained at a constant length, but mutations in four different genes: LF1, LF2, LF | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | $309,922 | Grant | Trans-NIH Recovery Act Research Support: The goal of our research is to identify and characterize the machinery involved in eukaryotic DNA replication. We focus on the isolation of the individual proteins and protein complexes required for DNA synthesis and define their role in this critical mac | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | $191,118 | Grant | Trans-NIH Recovery Act Research Support: The DNA of eukaryotic species is organized into chromatin, a highly condensed state implicated in key cellular functions and implicated in numerous diseases, including cancer. DNA compaction into chromatin is aided by specialized proteins called histones | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $323,766 | Grant | Trans-NIH Recovery Act Research Support: This research will examine how cells monitor the synthesis of rRNA, the essential component of protein synthesizing machinery, and regulates metabolism and other cellular activities. | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $66,954 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Plants have ancient classes of reproductive and vegetative actin genes with distinct expression patterns. During the last grant period we have examined the hypothesis that these ancient actin genes were preserved throu | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $150,652 | Grant | Trans-NIH Recovery Act Research Support: The continuing development of synthesis strategies based on the chemistry of alkynyliodonium salts and their derived alkylidenecarbenes will occupy the majority of the proposed efforts. The alkynyliodonium salt-based chemistry will find purchase in total | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| TRUSTEES OF PRINCETON UNIVERSITY, THE | $100,000 | Grant | Trans-NIH Recovery Act Research Support: Our long-term objectives are to define the pathway by which two haploid yeast cells fuse to become one diploid cell. Related to fertilization, conjugation is a fundamental process common to all sexually reproducing organisms. Conjugation also has close pa | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $109,080 | Grant | Trans-NIH Recovery Act Research Support: The molecular mechanisms of gamete fusion remain poorly understood in most organisms. Currently, Chlamydomonas is the only organism in which two proteins have been shown by gene disruption to be essential for the membrane fusion reaction. Our ability to | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, THE | $278,138 | Grant | Trans-NIH Recovery Act Research Support: This is an extension of the studies supported by the parent grant. The main scope of the parent grant is to map the functional and physiological components of the inflammatory reflex. Extensive work carried out under the parent grant demonstrated that th | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| MISSOURI SYSTEM, UNIVERSITY OF | $204,545 | Grant | Trans-NIH Recovery Act Research Support: The supplementary work will lend biophysical insight into MMP activity and roles of exosites in elastase activity and in green tea inhibition of MMP-12. Postdoctoral staff will be retained, PhD students hired and trained, and useful equipment acquired. | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | $214,512 | Grant | Trans-NIH Recovery Act Research Support: This award is issued in response to Notice OD-09-060, Recovery Act Administrative Supplements Providing Summer Research Experiences for Students and Science Educators.PROJECT SUMMARY/ABSTRACTHedgehog (Hh) proteins are secreted morphogens that regulate nor | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| NORTHWESTERN UNIVERSITY | $106,276 | Grant | Trans-NIH Recovery Act Research Support: This supplement will be used to purchase equipment that will allow the PI to delagate routine experiments to a skilled laboratory technician. Also to re-hire a former laboratory technician for a part time position. These investments will allow the lab t | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $190,464 | Grant | Trans-NIH Recovery Act Research Support: The objective of the proposed work is to understand how the Dmrt1 gene controls development and function of the testis. The testis has two essential functions: production of sperm, the cells that serve as vehicles for the immortality of male germ line DNA | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| UNIVERSITY OF MONTANA SYSTEM | $114,671 | Grant | Trans-NIH Recovery Act Research Support: This research will help us understand the role of calcium ions in the secretory pathway, defects in which are the basis of many human diseases. This supplement would provide partial salary support for a post doc to work on specific Aims 2 and 3 of the fu | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF PRINCETON UNIVERSITY, THE | $85,000 | Grant | Trans-NIH Recovery Act Research Support: The extracellular matrix (ECM) is critical for cellular decision-making through its role in tissue architecture and its stimulatory effects on cell growth, migration, and differentiation. Transmission of ECM signals is carried out by integrin receptors th | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF NOTRE DAME DU LAC | $113,243 | Grant | Trans-NIH Recovery Act Research Support: Microtubule motor proteins are responsible for many aspects of intracellular transport and cytoplasmic dynein is a major minus end-directed motor in mammalian cells which orchestrates the movement of membranes, chromosomes and mitotic spindles. We do not | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| DUKE UNIVERSITY | $134,951 | Grant | Trans-NIH Recovery Act Research Support: The overall objective of this competing R01 renewal is the continued development of the Elastin Fusion Protein technology as a genetically encodable, biomimetic analog of -smart protein-polymer conjugates. The overall objective is motivated by the rationa | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| OHIO STATE UNIVERSITY, THE | $94,971 | Grant | Trans-NIH Recovery Act Research Support: During the previous funding cycle, we determined that a UAG-codon, located in the M. barkeri monomethylamine methyltransferase, encoded a new amino acid. Based on its electron density in the native and hydroxylamine complexes, we determined that the amino | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF IDAHO | $71,309 | Grant | Trans-NIH Recovery Act Research Support: Eukaryotic cilia and flagella are ancient cellular appendages that have been adapted for motile and sensory functions. Motile forms of these organelles are capable of propelling some cells like sperm and protozoa through a liquid environment while other | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF RHODE ISLAND | $102,935 | Grant | Trans-NIH Recovery Act Research Support: This is a revision application in response to the announcement NOT-OD-09-058: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications This revision application proposes a set of studies to extend the specific aims of the | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $67,841 | Grant | Trans-NIH Recovery Act Research Support: Translation initiation is a central biological process. It is also a key point in the regulation of gene expression. Eukaryotic translation initiation is a potential target of anticancer, antiviral and antifungal drugs. Attempts to develop drugs targeting | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF CHICAGO, THE | $224,067 | Grant | Trans-NIH Recovery Act Research Support: Pre-mRNA splicing must occur with high fidelity to prevent catastrophic errors. Yet, the molecular mechanisms of fidelity in splicing are understood poorly. Splicing is catalyzed by the spliceosome, a dynamic ribonucleoprotein machine in which small nucle | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $118,360 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this project is to define the role of the novel lipid pathway mediated by sphingosine-1-phosphate (S1P) in inflammation and to establish components of this pathway as potential novel targets for anti-inflammatory therapy. The PI?s la | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TEXAS A & M RESEARCH FOUNDATION | $227,785 | Grant | Trans-NIH Recovery Act Research Support: Telomeres are higher order nucleoprotein structures that physically cap the chromosome terminus and help to preserve genome integrity. In cells with unlimited proliferative capacity, including 95% of human cancers, telomeres are maintained by telomerase. | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| GEORGIA TECH RESEARCH CORPORATION | $108,788 | Grant | Trans-NIH Recovery Act Research Support: Integrin-mediated cell adhesion to extracellular matrices regulates the organization, maintenance and repair of numerous tissues, and abnormalities in adhesive interactions are often associated with pathological states. The adhesive process comprises inte | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| DUKE UNIVERSITY | $262,516 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement requests additional equipment and personnel. One GRA will work on the structure determination of a large and exciting new protein, whose structure is unknown. This will provide a good test for our algorithms and also an exce | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| FLORIDA STATE UNIVERSITY, THE | $61,774 | Grant | Trans-NIH Recovery Act Research Support: This is an equipment supplement to the parent grant whose overall objectives are to develop and apply new nuclear magnetic resonance (NMR) methods and web-based technology for the rapid and reliable collection, processing, and analysis of NMR spectra of l | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $391,368 | Grant | Trans-NIH Recovery Act Research Support: Our overall hypothesis is that PI4KII? (phosphatidylinositol 4 kinase II?), which produces more than 50% of the phosphatidylinositol 4 phosphate (PI4P) in the Golgi, regulates Golgi functions through its localized production of PI4P. The PI4P itself estab | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $71,200 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this work is to exploit our one-of-a-kind, high sensitivity flow and stopped-flow EPR to probe the real time folding and recognition of spin labeled biomolecules with a time resolution extending from 50 microseconds to seconds. The areas to | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF FLORIDA | $75,000 | Grant | Trans-NIH Recovery Act Research Support: Our long-term goal in grant GM066859 (Bioinorganic Chemistry of Nickel: The Ureases and Nikr) is to understand protein structure, function and dynamics. Furthermore, the proposal is focused on understanding the fundamental aspects of bioinorganic biocatal | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $72,710 | Grant | Trans-NIH Recovery Act Research Support: This grant provided a supplement to by RO1, entitled !A model system to study the tumor suppressor APC!. : The supplement allowed us to retain two very talented senior postdocs, David Roberts and Nasser Rusan, who were key to advancing our IRG-approved | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | $572,363 | Grant | Trans-NIH Recovery Act Research Support: This research program focuses on the development of new synthetic strategies for the total synthesis of biologically active complex alkaloid natural products. Within each total synthesis goal lies the implicit aim of discovering and exploiting new reactio | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $94,409 | Grant | Trans-NIH Recovery Act Research Support: The process of DNA replication during S phase of the cell cycle is constantly challenged by the presence of damaged DNA on the replication template. Base lesions in chromosomes can cause DNA polymerase stalling, and if the stalled polymerase is not resolv | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $67,594 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Expression of the X-linked inhibitor of apoptosis (XIAP) is greatly enhanced in many classes of malignancy, and strategies to suppress XIAP function are showing great promise in the treatment of cancer. Although XIAP i | Health and Human Services, Department of / National Institutes of Health | 9/10/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $278,100 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The long-term goal of this proposal is to understand the molecular and cellular mechanisms of signal termination mediated by the novel phosphatase PHLPP (PH domain Leucine-rich repeat Protein Phosphatase; pronounced 'f | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $708,025 | Grant | Trans-NIH Recovery Act Research Support: The HOG pathway is a well-characterized mitogen-activated protein kinase (MAPK) cascade in yeast. MAPK pathways are evolutionary-conserved eukaryotic signaling modules that regulate diverse cellular processes including pheromone signaling, metabolism, dif | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $84,833 | Grant | Trans-NIH Recovery Act Research Support: RNA acts as information carriers, catalysts, and regulators in essential biological processes, and understanding RNA structure and function is intimately linked to combating diseases. The long-term objectives of this project is to advance our understandin | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| UNIVERSITY OF IOWA, THE | $51,710 | Grant | Trans-NIH Recovery Act Research Support: Infection of humans with Plasmodium species, the parasites that cause malaria, remains a significant global health problem. There are approximately 300-500 million new cases of malaria each year, which results in the death of 1-3 million people annually. | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| ST. JUDE CHILDREN'S RESEARCH HOSPITAL | $97,684 | Grant | Trans-NIH Recovery Act Research Support: Type 1 diabetes Is an autoimmune disease that occurs when autoreactive T cells attack and kill the insulin producing cells of the pancreas. Currently, the disease is treated by repeated insulin Injections, however there is no cure. Prolonged periods of un | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| WHITEHEAD INSTITUTE FOR BIO-MEDICAL RESEARCH | $92,824 | Grant | Trans-NIH Recovery Act Research Support: Large-scale genome sequencing has revealed that some organisms have genomes that encode for an astonishing number of proteins with domains of extremely low sequence complexity. Although the folding and function of these domains is poorly understood, they | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| NORTHWESTERN UNIVERSITY | $92,824 | Grant | Trans-NIH Recovery Act Research Support: The movement of leukocytes across the endothelial cell layer of blood vessels is critical to mounting an effective inflammatory response but is also a connected pathology of such diseases at athersclerosis, mutliple sclerosis and arthritis. This poorly un | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $500,000 | Grant | Trans-NIH Recovery Act Research Support: This award will provide partial funding for renovation of Bldg 12 at the JHU farm to provide space for the expansion of an NIH supported colony of pigtailed macaques. These animals are used in NIH funded programs at Johns Hopkins and other institutions in | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| NATIONAL JEWISH HEALTH | $489,880 | Grant | Trans-NIH Recovery Act Research Support: National Jewish Medical and Research Center is a small, private, non-profit hospital that has developed an international reputation as the top Respiratory Hospital in the United States the past 10 years according to U.S. News and World Report. To add to t | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| SALK INSTITUTE FOR BLOGICAL STUDIES | $500,000 | Grant | Trans-NIH Recovery Act Research Support: The Salk Institute for Biological Studies is a non-profit research institution devoted to making fundamental discoveries in the life sciences, the improvement of human health and the training of future generations of researchers. Salk is arguably one of t | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| NEW YORK UNIVERSITY | $500,000 | Grant | Trans-NIH Recovery Act Research Support: This grant application addresses necessary facility improvements at NYUG??s two main animal facilities at the Washington Square Campus critical to support funded investigators in Neural Science, Biology, and associated departments of the University and t | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| NORTHWESTERN UNIVERSITY | $886,926 | Grant | Trans-NIH Recovery Act Research Support: Mortality of patients with chronic lung diseases continues to ncrease in the United States. Understanding the mechanisms of how the lung responds to injury and how this leads to abnormal lung healing is key to the development of novel therapeutic strategi | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| TEXAS HEART INSTITUTE | $1,073,030 | Grant | Trans-NIH Recovery Act Research Support: This grant supports a new independent investigator in molecular cardiology research. The new investigator will study genetic and molecular aspects of congenital heart defects (CHDs) with the goal of providing new insights into the mechanisms underlying d | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $696,982 | Grant | Trans-NIH Recovery Act Research Support: The Gene and Cell Therapy Program (GCTP) at Indiana University is a highly interactive group of investigators with a 15-year history of multi-departmental interaction and collaborative research. The program has a focus on the genetic manipulation of stem | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| THE VANDERBILT UNIVERSITY | $1,440,717 | Grant | Trans-NIH Recovery Act Research Support: The Vanderbilt Program in Drug Discovery (VPDD) is a world class effort fully focused on discovery and characterization of novel molecules to evaluate new potential treatment strategies for CNS disorders. The VPDD has had tremendous success in discovery o | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $1,349,654 | Grant | Trans-NIH Recovery Act Research Support: The Center for Learning and Memory (CLM) at The University of Texas at Austin engages in a multidisciplinary approach to the study of the neurobiology of learning and memory. The CLM facilitates the exchange of ideas and expertise across different discipl | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $1,650,000 | Grant | Trans-NIH Recovery Act Research Support: Purpose of this application is to form a partnership between the NIH and Tufts Neuroscience Department which will allow the expansion of our program by hiring additional tenure-track assistant professors. With funds from this award and from Tufts Univers | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $1,292,007 | Grant | Trans-NIH Recovery Act Research Support: A new Assistant Professor will be recruited to the Department of Physiology of the University of Wisconsin School of Medicine and Public Health. The Department will recruit an outstanding researcher in the field of Synaptic Function, and this new faculty | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $858,064 | Grant | Trans-NIH Recovery Act Research Support: During atherogenesis, eicosanoid biosynthesis is altered by mechanisms that are not well understood. Consistent with the essential nature of eicosanoid equilibrium, prostaglandin H2 synthase (PGHS, colloquially known as COX) enzymes produce prostaglandin | Health and Human Services, Department of / National Institutes of Health | 6/21/2009 |
| THE UNIVERSITY OF SOUTH DAKOTA | $1,089,229 | Grant | Trans-NIH Recovery Act Research Support: The prevalence of heavy alcohol consumption and associated problems is elevated among college students. Alcohol-related problems are multifaceted with a complex etiology. Alcohol problems are commonly organized into two related dimensions, abuse and depen | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| BOSTON BIOMEDICAL RESEARCH INSTITUTE, INC. | $47,096 | Grant | Trans-NIH Recovery Act Research Support: This ARRA award is a supplement to support summer stipends for two undergraduate research students who will receive training in biomedical research while contributing to ongoing research for the parent project. | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF UTAH, THE | $74,281 | Grant | Trans-NIH Recovery Act Research Support: Though most chronic diseases/conditions in childhood are very uncommon (<1/3000), together they affect about 13% of children in the United States. A busy pediatrician or family physician will care for many such patients, though few, if any, of her/his oth | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| THE JACKSON LABORATORY | $66,162 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement is to accelerate the pace of the parent project by providing additional curation and programming resources for the International Mouse Strain Resource (IMSR). The IMSR facilitates access to mouse resources and mouse models o | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| UNIVERSIDAD CENTRAL DEL CARIBE INC | $899,836 | Grant | Trans-NIH Recovery Act Research Support: ENHANCEMENT OF THE HIV AND SUBSTANCE OF ABUSE LABORATORY CORE. The enhancement of the HIV and Substance of Abuse Laboratory Core (H-SALC) will advance our present efforts of providing human resources and infrastructure needed to support research studies i | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF IOWA, THE | $50,000 | Grant | Trans-NIH Recovery Act Research Support: In this K01 application, Philip Polgreen, MD, seeks to gain expertise in graph theory pertaining to social networks and in mathematical simulations for developing more effective interventions to minimize the spread of nosocomial infections (specifically i | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF WASHINGTON | $49,995 | Grant | Trans-NIH Recovery Act Research Support: In July 2008, Rachel Winer, PhD received a K01 award (the parent grant) to conduct a longitudinal study of high-risk (HR) human papillomavirus (HPV) infections in 25 to 65 year old women who date online. To date, 220 women have been enrolled (target enrol | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $50,000 | Grant | Trans-NIH Recovery Act Research Support: This proposal describes a 5 year training program for the development of an academic career in Cardiovascular Transcriptional Biology. The principal investigator has scientific background with expertise in cellular immunology. He will now embark upon a p | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF MASSACHUSETTS | $65,281 | Grant | Trans-NIH Recovery Act Research Support: The objective of the ARRA administrative supplement is to support Dr. Doubeni's accelerated career development program in key scientific areas that will position him to become an independently funded researcher. The supplement supports studies on cancer | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $401,025 | Grant | Trans-NIH Recovery Act Research Support: The goal of our program project is to understand the mechanisms of drug resistance in treated HIV infected patients. The work supported by the supplement facilitates these studies in two areas. First it enables us to expand our studies to include the HIV | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| SALK INSTITUTE FOR BLOGICAL STUDIES | $142,050 | Grant | Trans-NIH Recovery Act Research Support: The overarching goal of this program project is to build bridges across disciplines, linking higher cognitive functions to their underlying neurobiological bases and their molecular genetic underpinnings using a specific genetic disorder, Williams syndrom | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $1,375,775 | Grant | Trans-NIH Recovery Act Research Support: Polycystic ovary syndrome (PCOS) is a heterogeneous syndrome affecting 5-10% of women of reproductive age. It is characterized by elevated circulating insulin, reduced insulin sensitivity, infertility, hyperandrogenism, and a multitude of symptoms that r | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $521,442 | Grant | Trans-NIH Recovery Act Research Support: The Development of Object Representation in Infancy--the broad goal of this project is to understand how typically developing infants learn about and remember objects. Understanding the typical development of aspects of learning and memory is important fo | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $939,605 | Grant | Trans-NIH Recovery Act Research Support: Pain and anxiety in children undergoing surgery continues to be a significant public health issue. Indeed, every year three million children who undergo surgery will suffer significant pain after surgery and high anxiety prior to surgery. Many more mill | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $898,644 | Grant | Trans-NIH Recovery Act Research Support: In many situations people have to process simultaneously presented auditory and visual information, and this ability is especially important for lexical development where auditorily presented words often co-occur with visually presented objects and scenes | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| UNIVERSITY OF FLORIDA | $728,315 | Grant | Trans-NIH Recovery Act Research Support: The ~2 Mb Prader-Willi/Angelman syndrome (PWS/AS) domain encompasses a group of imprinted genes that are coordinately regulated by a bipartite imprinting center (IC). The PWS-IC functions to establish and maintain the paternal epigenotype across the domai | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $874,859 | Grant | Trans-NIH Recovery Act Research Support: Although the link between maternal and child depression is well established, little is known about the mechanisms by which this risk is conferred. The proposed study is designed to address this gap. In so doing, we seek to integrate and extend findings fr | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF PITTSBURGH THE | $526,615 | Grant | Trans-NIH Recovery Act Research Support: Research the pathogenesis of the lysosomal storage disease mucolipidosis type IV (MLIV) is why dysregulation of the ion channel TRPML1 lead to buildup of storage bodies. Finding whether TRPML1 directly regulates membrane traffic or lysosomal lipid hydroly | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| DUKE UNIVERSITY | $816,679 | Grant | Trans-NIH Recovery Act Research Support: The therapeutic utility of inhibiting/modulating progesterone receptor (PR) transcriptional activity in uterine fibroids has been well validated both in preclinical models of this disease and in several definitive clinical studies. Indeed, both antiproges | Health and Human Services, Department of / National Institutes of Health | 7/28/2009 |
| UNIVERSITY OF NEBRASKA | $49,028 | Grant | Trans-NIH Recovery Act Research Support: his proposal describes a research plan to biosynthesize HSAF (dihydromaltophilin), a broad spectrum antifungal natural product with a new mode of action. HSAF was isolated from Lysobacter enzymogenes C3, a bacterium used in the biological control of funga | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF PUERTO RICO-MEDICAL SCIENCES CAMPUS | $37,500 | Grant | Trans-NIH Recovery Act Research Support: Our long-term objective is to conduct a large, island-wide, population-based, genetic-epidemiologic study of familial colorectal cancer in Puerto Rico. The overall goal of this porposal is to determine the feasibility for implementation of a population-b | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $37,448 | Grant | Trans-NIH Recovery Act Research Support: The project involves testing the role of Runx1 in intestinal cancer in mouse models. | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| SAINT LOUIS UNIVERSITY | $70,881 | Grant | Trans-NIH Recovery Act Research Support: This research project will investigate the neural circuits underlying fundamental cognitive learning abilities in deaf children with cochlear implants. This knowledge is important because it will help elucidate why many deaf children display language lear | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| THE CHILDRENS HOSPITAL LOS ANGELES | $79,259 | Grant | Trans-NIH Recovery Act Research Support: This supplement application proposes to augment the RO3 Modern Genetic Testing in the Pediatric Critical Care Environment (Upperman, PI) awarded by the NICHD in July 2009. We propose to enhance data collection activities in Phase 1 to include focus groups | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF FLORIDA | $36,625 | Grant | Trans-NIH Recovery Act Research Support: This work proposes to expose medical students to abnormal clinical conditions through the use of immersive virtual patients (VPs). Immersive VPs are highly interactive, computer-generated, life-size virtual 3D characters. As medical educators have diffi | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| LAWRENCE UNIVERSITY | $30,824 | Grant | Trans-NIH Recovery Act Research Support: The long-range goal of this research proposal is to elucidate how rhinovirus (RV) activation of macrophages contributes to the exacerbations of asthma. Virus-induced asthma is resistant to therapy; therefore knowledge about the cellular processes critical | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| WESTERN ILLINOIS UNIVERSITY INC | $122,781 | Grant | Trans-NIH Recovery Act Research Support: Cathepsins B, D, and K have been suggested to play important roles in the metastatic potential of several types of cancer, and have been implicated in the pathology of a wide variety of diseases. Most assume cathepsins B, D, and K to be restricted to the | Health and Human Services, Department of / National Institutes of Health | 6/19/2009 |
| CLEMSON UNIVERSITY | $175,156 | Grant | Trans-NIH Recovery Act Research Support: The objective of this project is to develop neomycin-TFOs that directly target the ets2 gene, found amplified in breast and prostate cancer. The proposed work will overcome important challenges such as TFO affinity to the duplex and delivery to the cells | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $31,551 | Grant | Trans-NIH Recovery Act Research Support: A Biotechnology Training Program in Biomedical Science and Engineering To Educate and To Train the Next Generation of Scientists and Engineers for Leadership Roles in Multidisciplinary Biotechnology Research | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| CALIFORNIA STATE UNIVERSITY AUXILIARY SERVICES, INC | $179,539 | Grant | Trans-NIH Recovery Act Research Support: Specific Aims and Measurable Objectives: All science undergraduates are considered pre-MARC U*STAR Trainees. We intend to deepen the pool of freshman and sophomore students who attain honors level of academic achievement and thus are eligible to apply for | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $261,084 | Grant | Trans-NIH Recovery Act Research Support: This adminstrative supplement provides funding for three additional pre-doctoral trainee positions for the existing Training Program in Quantitative Biology and Physiology. In the spirit of ARRA goals, the additional slots will be used for new appointment | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| THE VANDERBILT UNIVERSITY | $87,028 | Grant | Trans-NIH Recovery Act Research Support: The objectives of this training program is to provide significant biological training to students receiving in-depth training in synthetic/mechanistic chemistry and to provide significant training in synthetic/mechanistic chemistry to students receiving i | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| COLD SPRING HARBOR LABORATORY ASSOCIATION, INC. | $82,532 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement supports an additional predoctoral position on an existing Institutional Training grant in Cellular, Biochemical, and Molecular Sciences, T32GM065094, that was awarded to the Watson School of Biological Sciences at Cold Spri | Health and Human Services, Department of / National Institutes of Health | 8/07/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $112,779 | Grant | Trans-NIH Recovery Act Research Support: No jobs created or retained during this quarter. | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $78,068 | Grant | Trans-NIH Recovery Act Research Support: The University of Southern California (USC) Training Program in Cellular, Biochemical, and Molecular Sciences (CBM Training Program) prepares students for careers in interdisciplinary biomedical research and related occupations. Major goals of the Program | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| DUKE UNIVERSITY | $180,716 | Grant | Trans-NIH Recovery Act Research Support: We have designed a training program for PhD students in Bioinformatics, Genome Technology and Computational Biology. Once it became apparent that modern biology would be increasingly dependent on quantitative methods, several approaches to training arose, | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| UNIVERSITY OF ARIZONA | $233,376 | Grant | Trans-NIH Recovery Act Research Support: This program will prepare scientists for research careers in the computational analysis and mathematical modeling of medically significant biological systems through interdisciplinary training at the protectoral level. Noted for its well-established syst | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| MOUNT ST MARY'S COLLEGE | $66,008 | Grant | Trans-NIH Recovery Act Research Support: Mount St. Mary's College will create a comprehensive interdisciplinary curriculum for Biology majors that will increase students' understanding of and ability to use theory and quantitative concepts in the biological sciences. This curriculum will prepare | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $635,455 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this award (of a Revision Application) was to begin fulfilling a need of the NIAAA-funded INIA West consortium to use electrophysiological methods to study the function of gene products suggested by the molecular components (particularly th | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| WASHINGTON UNIVERSITY, THE | $1,383,237 | Grant | Trans-NIH Recovery Act Research Support: This proposal seeks to advance T1 and T2 translational research at the Washington University Institute of Clinical and Translational Sciences (ICTS) by establishing a new multidisciplinary Lifestyle Intervention Research Core (LIRC) to assess lifestyle (i | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF CHICAGO, THE | $857,156 | Grant | Trans-NIH Recovery Act Research Support: The ultimate goals of the University of Chicago CTSA program are to train scientists and health care providers at the University, our partner institutions, and our community to determine the molecular underpinnings of disease or disease predisposition in | Health and Human Services, Department of / National Institutes of Health | 9/26/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $533,053 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this application is to enhance both the process and benefits of clinical andtranslational research by bringing together the diverse resources of the Johns Hopkins Medical Institutions (JHMI) and creating a new model for carrying out scienti | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $269,834 | Grant | Trans-NIH Recovery Act Research Support: The CTSA Leadership has recognized training and career development of clinical and translational scientists as a strategic goal, calling for open access to training resources across the CTSA Consortium, and for the development of mentorship training progr | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| NORTHWESTERN UNIVERSITY | $539,292 | Grant | Trans-NIH Recovery Act Research Support: This CTSA supplemental award is to accelerate the involvement of engineers in the biomedical research and translation process at Northwestern University by 1) instituting a new structured training program in clinical and translational research for enginee | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $417,428 | Grant | Trans-NIH Recovery Act Research Support: True community engagement in Clinical and Translational Research (CTR) is unlikely to occur until our CTR work force is diversified. The purpose of this ARRA administrative supplement is to establish a bi?directional CTR Scholars Program in collaboration | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $568,156 | Grant | Trans-NIH Recovery Act Research Support: Community Leadership and Reciprocal Development to Advance Community Engaged Research at Two CTSA Institution There is a growing recognition that translational research benefits from community engagement at the outset. The NC Translational and Clinical Sc | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| GEORGIA HEALTH SCIENCES UNIVERSITY RESEARCH INSTITUTE, INC. | $147,000 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this project is to examine the effects of cocaine dependency on renal physiology in African Americans (AAs). Cocaine-dependent AAs are at risk for sub-clinical renal damage resulting from cocaine use, yet little data exists to guide cl | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| UNIVERSITY OF WASHINGTON | $371,843 | Grant | Trans-NIH Recovery Act Research Support: The recruitment of American Indians and Alaska Natives (AI/AN) to participate in research is complicated by a long and troubled history between researchers and Native populations of the United States regarding the collection of Native American remains, cu | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $978,256 | Grant | Trans-NIH Recovery Act Research Support: Community Voices on Health Disparities and Translational Genomics Research Challenge Area and Specific Challenge Topic: The Challenge Area this research addresses is 02: Bioethics and the Specific Challenge Topic is 02- OD9OSP-102* Ethical Issues in Healt | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $967,378 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (06) Enabling Technologies, and Specific High-Priority Topic Area 06-OD(OBSSR)-101* 'Using new technologies to improve or measure adherence'. The chronic diseases that co | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF ROCHESTER | $936,627 | Grant | Trans-NIH Recovery Act Research Support: This application addresses the broad Challenge Area (06) Enabling Technologies, and specific Challenge Topic, 06-OD(OBSSR)-101*: Using new technologies to improve or measure adherence. We propose the development and testing of a novel technology to improv | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $896,769 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (04): Clinical Research, and specific Challenge Topic, 04- HL-104: Perform secondary analyses of existing data to answer important clinical and preventive medicine research questions. Atrial fibrillation (AF | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $966,490 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by investigator): This application addresses broad Challenge Area (08) Genomics and specific Challenge Topic, 08-HL-104: Assess genetic variation in African Americans and determine its effect on disease. Genome-wide association studi | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $394,602 | Grant | Trans-NIH Recovery Act Research Support: The long term goal of this research program is to define the role of the Origin Recognition Complex (ORC) during the cell cycle in eukaryotes. ORC, a heteromeric six-subunit protein complex, is essential for DNA replication, however, its functions extend | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $218,500 | Grant | Trans-NIH Recovery Act Research Support: This application is in response to NOT-OD-09-058, NIH announces the availability of Recovery Act funds for competitive revision applications. My R01 investigates the biochemical and cellular functions of mammalian formin proteins, which are potent actin a | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $100,000 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this supplement is to obtain funding to purchase a high mass accuracy mass spectrometer to support work being done under the parent grant. The parent grant seeks to establish the targets and regulators of cullin-dependent ubiquitin ligases, | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $137,751 | Grant | Trans-NIH Recovery Act Research Support: Members of the CLC family orchestrate the movements of chloride necessary for proper neuronal, muscular, cardiovascular, and epithelial function. Although certain eukaryotic CLC channels have been well characterized functionally, we remain in the dark ab | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| TEXAS A & M RESEARCH FOUNDATION | $88,229 | Grant | Trans-NIH Recovery Act Research Support: The long-term objective of this project is to learn more about how chromatin structure regulates transcriptional gene silencing in eukaryotes. The basic mechanisms used to generate inactive or silent chromatin are largely conserved in eukaryotic organisms | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $439,930 | Grant | Trans-NIH Recovery Act Research Support: The goal of the parent grant is to investigate protein-ligand and protein-protein interactions in HIV-1 reverse transcriptase (RT). Being a key player in HIV infection, RT is the molecular target of the majority of AIDS drugs. The biologically active en | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY | $142,734 | Grant | Trans-NIH Recovery Act Research Support: Type IV pill (Tfp) are important determinants of bacterial virulence and biofilm formation which is the cause of many opportunistic and chronic bacterial infections. Tfp also mediate a form of bacterial surface motility known as social (S) gliding in Myxo | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $106,619 | Grant | Trans-NIH Recovery Act Research Support: The goal of this supplement is to rapidly break new ground in chromosomal mechanisms and cellular function. This supplement has enabled us to purchase equipment to accelerate the rate of our research activities and has enabled us to perform the experim | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| WAYNE STATE UNIVERSITY (INC) | $151,195 | Grant | Trans-NIH Recovery Act Research Support: The goal of the collaborative research proposed here is to establish a proof-of-principle that will provide foundations for the development of such technique(s). The novelty of our approach is in the use of a laser beam to selectively activate the transc | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE | $69,768 | Grant | Trans-NIH Recovery Act Research Support: Biophysical Optimization of Oligonucleotide Microarrays High-quality, quantitative microarrays are an absolute requirement of array experiments involving comparative analysis of related genomes, or sensitive and specific diagnosis of infectious disease. | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY | $107,719 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this project is to develop detailed spatial models of cell signaling networks to understand the origins and dynamics of microdomains of signaling components. We will combine spatially realistic models developed in the program Virtual | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| WISTAR INSTITUTE OF ANATOMY & BIOLOGY (INC) | $125,022 | Grant | Trans-NIH Recovery Act Research Support: Wound and tissue injuries are common medical problems that often lead to excessive scar formation and subsequent loss of organ function without normal tissue replacement. Understanding the molecules that control scarless regenerative healing can provide a | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $115,125 | Grant | Trans-NIH Recovery Act Research Support: The central objective of this project is to determine how RNA is recognized and cleaved by Dicer enzymes during induction of RNA interference. Three specific aims were proposed in the original application: 1) to compare the activities and specificities of | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $109,801 | Grant | Trans-NIH Recovery Act Research Support: The proposed supplement will enable the continued work of a talented postdoctoral researcher, Dr. Stephane Roche, on a project which is related to but distinct from the parent proposal (Project 2: Biomimetic Synthesis of Rocaglamide Derivatives and Relate | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $114,000 | Grant | Trans-NIH Recovery Act Research Support: As defined in the project abstract, the purpose of this proposal was to request supplemental funding for the purchase of critical scientific equipment to be used to accelerate the pace of research conducted under the IGR-approved scope of the parent grant | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $53,307 | Grant | Trans-NIH Recovery Act Research Support: Centrosomes are microtubule-organizing centers (MTOCs) consisting of two centrioles surrounded by pericentriolar material. Accurate centrosome duplication precisely once per cell cycle is required for formation of a bipolar mitotic spindle, the apparatus | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE | $55,387 | Grant | Trans-NIH Recovery Act Research Support: Ubiquitin-like modifications are similar to other macromolecular chemistry, such as transcription and DMArepair, in that they require multiple steps that are carried out by multi- protein complexes. Better understanding of how the multi-protein machinery | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| BROOKHAVEN SCIENCE ASSOCIATES, LLC | $256,405 | Grant | Trans-NIH Recovery Act Research Support: Eukaryotic chromosomal replication is an intricate process that requires the coordinated and tightly regulated action of numerous molecular machines. Failure to ensure once only replication initiation per cell cycle can result in uncontrolled proliferatio | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| HEALTH RESEARCH, INC. | $127,220 | Grant | Trans-NIH Recovery Act Research Support: Many organisms show daily oscillations of various physiological and behavioral processes, which are generated by a genetically determined circadian clock system. It is believed that the circadian system has evolved to provide the most efficient responses | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $82,360 | Grant | Trans-NIH Recovery Act Research Support: G protein-coupled receptors (GPCRs) constitute a superfamily of cell surface receptors that regulate a variety of cell functions. The function of GPCRs is dictated by their intracellular trafficking and the positioning at the cell membrane. Indeed, defect | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $477,560 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to take the advantages of the sialosides produced, the chemoenzymatic synthetic strategies designed, and the assay methods developed in the parent grant (R01GM076360, entitled Studies of naturally occurring structurally modifie | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $162,630 | Grant | Trans-NIH Recovery Act Research Support: Phosphorylation Dependent Recognition of a Histone mRNA Hairpin by SLBP (ARRA) Replication-dependent histone mRNAs express the bulk of histone proteins in mammalian cells. Histone proteins are required for proper packaging of DNA into nucleosomes and for | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| DUKE UNIVERSITY | $343,199 | Grant | Trans-NIH Recovery Act Research Support: We study the mechanisms that govern the partitioning of mRNAs between the cytosol and endoplasmic reticulum (ER) of eukaryotic cells. This transcriptome sorting process is arguably the most universal of the mRNA localization events and is responsible for | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF ARIZONA | $39,587 | Grant | Trans-NIH Recovery Act Research Support: The primary goal for this grant is to uncover the structural and functional bases for signaling through S-nitrosation. Perhaps the most important target for these studies is the nitric oxide receptor, soluble guanylate cyclase (sGC), a hetrodimeric prote | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $169,332 | Grant | Trans-NIH Recovery Act Research Support: Transport systems provide essential functions for all living cells. Their importance to medicine cannot be overemphasized as (1) they provide a basis for multidrug resistance in pathogenic bacteria, fungi and protozoans as well as in tumor cells, (2) they | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| UNIVERSITY OF CALIFORNIA, SANTA CRUZ | $111,571 | Grant | Trans-NIH Recovery Act Research Support: The organization of the nucleus into distinct structural and functional domains is important for normal chromosomal processes like transcription and replication and disruption of this organization is known to lead to disease states like cancer and develop | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF CHICAGO, THE | $247,383 | Grant | Trans-NIH Recovery Act Research Support: The objective of this research is to systematically study new genes in the Drosophila melanogaster subgroup and to investigate the tempo and mode of new gene originations. We will focus on the new chimerical genes created by RNA-involved retroposition tha | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | $184,414 | Grant | Trans-NIH Recovery Act Research Support: Amyloid deposition occurs in more than twenty different human diseases. This project is concerned with amyloid formation by Islet Amyloid Polypeptide (IAPP), the endocrine hormone responsible for pancreatic islet amyloid in type 2 diabetes. Islet amyloid | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $80,000 | Grant | Trans-NIH Recovery Act Research Support: GM078163-Molecular Mechanism of Small RNA-induced RNA Silencing: A supplementary equipment grant for purchasing the ?AKTA-micro? machine from GE. A small portion ($15,000-20,000) of the supplement will be used to purchase a 4 degree cooler to house the ? | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| NEW YORK UNIVERSITY (INC) | $288,219 | Grant | Trans-NIH Recovery Act Research Support: Signal transduction is a fundamental process that enables cells to acquire information from the extracellular environment and respond to this information appropriately. This awarded supplement will be used to focus on the establishment of new approaches | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | $532,000 | Grant | Trans-NIH Recovery Act Research Support: Our long-term goal is to understand essential, conserved genes and mechanisms driving myoblast fusion. Our central hypothesis in our proposal is that specific cytoskeletal rearrangements are critical for all myoblast fusions. Our strong preliminary result | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| LOYOLA UNIVERSITY | $217,379 | Grant | Trans-NIH Recovery Act Research Support: The p90 Ribosomal S6 kinases (RSKs) are immediately downstream effectors of mitogen activated protein kinases and play a major role in regulation of cell proliferation and survival. Among the four isoforms, RSK4 is the most dissimilar and also functionall | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $281,625 | Grant | Trans-NIH Recovery Act Research Support: Structure-Function Studies of DNA Mismatch Repair A major focus of parent grant is to use atomic force microscopy (AFM) to characterize the conformations of the multiprotein-DNA complexes that govern the initiation of DNA mismatch repair. AFM is a powerf | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| DREXEL UNIVERSITY | $93,337 | Grant | Trans-NIH Recovery Act Research Support: This award focuses on the structural and functional characterization of antimicrobial natural products. The precise molecular details of how these agents fold and how they recognize their targets will be derived from high resolution X-ray crystal structur | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| BRANDEIS UNIVERSITY | $241,642 | Grant | Trans-NIH Recovery Act Research Support: How cell cycle events are controlled with growth remains an important and perhaps the most important, outstanding question in prokaryotic biology. A group of conserved and essential GTPase proteins, related to Ras, have been implicated in cell cycle contr | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| MICHIGAN STATE UNIVERSITY | $189,920 | Grant | Trans-NIH Recovery Act Research Support: Improved understanding of disease mechanisms and drug target identification requires better understanding of how diseases alter cellular processes from the healthy state. Our group has developed an integrative pathway search algorithm that reconstructs ne | Health and Human Services, Department of / National Institutes of Health | 9/10/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $85,000 | Grant | Trans-NIH Recovery Act Research Support: Perhaps one of the most influential concepts in protein mass spectrometry has been the notion of enzymatic protein digestion to render a collection of peptides of suitable size for conventional tandem mass spectrometry (collisional-activation, CAD).1 Doub | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| DUKE UNIVERSITY | $225,036 | Grant | Trans-NIH Recovery Act Research Support: Apoptosis is a program of cellular suicide that leads to the elimination of individual cells from the midst of a living tissue without damaging overall tissue architecture. Many stimuli, both extracellular and intracellular impact the cellular decision to | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $364,139 | Grant | Trans-NIH Recovery Act Research Support: Findings from the Human Genome Project highlight the intricacy of interactions between cell regulation, genes and proteins. It is generally understood that biological functions and biological activities are controlled by subsets of genes interacting with | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF ILLINOIS | $54,600 | Grant | Trans-NIH Recovery Act Research Support: This award provides additional funding for 5R01GM081030-02 in the amount of $54,600. The purpose of the funding is to purchase additional equipment that will accelerate the progress of the parent project. Expected deliverables will include research publ | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| THE VANDERBILT UNIVERSITY | $59,134 | Grant | Trans-NIH Recovery Act Research Support: My RO1 grant (R01 GM081635; G?Biochemical reconstitution of heterotrimeric G proteins in the Wnt pathwayG?) consists of two aims: 1) Which heterotrimeric G proteins participate in canonical Wnt signaling? 2) What are the mechanisms by which G protein subu | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| BRANDEIS UNIVERSITY | $122,816 | Grant | Trans-NIH Recovery Act Research Support: A central concern of the present post-genomic era of biology is understanding the chemical and physical mechanisms by which gene expression is regulated. Appropriate activation and repression of particular genes is necessary for maintaining normal cell fu | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| THE VANDERBILT UNIVERSITY | $279,000 | Grant | Trans-NIH Recovery Act Research Support: We propose to determine the conformation of monomeric and dimeric arrestin2 in solution and the conformation of receptor-bound arrestin2 using multidimensional solution NMR methods. Using purified recombinant wild type (WT) arrestin2 expressed in E. coli | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $126,153 | Grant | Trans-NIH Recovery Act Research Support: This supplement request involves molecular biology, protein purification and crystallization training for high school and undergraduate students plus one high school science teacher. Participants will work under the guidance of university investigators ( | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF CHICAGO, THE | $38,770 | Grant | Trans-NIH Recovery Act Research Support: Despite a great deal of research, a complete understanding of the actions of general anesthetics is still not available. The objective of this research is to advance our understanding of isoflurane, with the hope of gaining insights into all anesthetics. | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $251,908 | Grant | Trans-NIH Recovery Act Research Support: High density lipoprotein (HDL) and its major protein component apolipoprotein (apo) A-1 exert prominent anti-inflammatory and anti-oxidant effects. Preliminary data presented in the parent application show that the apoA-1 mimetic peptide 4F, whose struct | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| THE INSTITUTE FOR CANCER RESEARCH | $229,307 | Grant | Trans-NIH Recovery Act Research Support: The parent award, R01 GM083025 G?Specificity of Effector Activation by Rho Family GTPasesG?, seeks to elucidate mechanisms regulating the activation of immediate downstream effectors of the Rho family GTPases Rac and Cdc42. Central to the proposed aims is | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $203,841 | Grant | Trans-NIH Recovery Act Research Support: A precise understanding of the sequence-stability relationship is of fundamental interest in protein biochemistry, as protein instability is a cause of a wide range of pathologies, and it would enable facile engineering of proteins for industrial and ther | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $216,816 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Neural circuits are the functional and structural units of the nervous system. Defects in neural circuit function and development lead to a variety of neurological disorders. We are interested in understanding how info | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| UNIVERSITY OF UTAH, THE | $140,424 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This proposal addresses novel mitochondrial-cytoplasm signaling pathways in Saccharomyces cerevisiae as a model eukaryote. In the first mitochondrial-cytoplasm pathway, we discovered a new paradigm in copper traffickin | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $333,888 | Grant | Trans-NIH Recovery Act Research Support: Our study will provide new insights into the control and manipulation of the p53 pathway, perhaps the most important pathway protecting human cells against the development of cancer. These studies will give a deeper understanding of the biological mechani | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF WASHINGTON | $124,499 | Grant | Trans-NIH Recovery Act Research Support: The long term goal of the parental grant is to gain a better understanding and control over human embryonic stem cells (hESCs) by identifying and manipulating the key microRNAs required for hESC self-renewal and differentiation. In the present supplement | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $71,620 | Grant | Trans-NIH Recovery Act Research Support: Necrosis, a catastrophic cell death caused by overwhelming stress, is a major contributor to human disease. However, very little effort has been made to develop therapies targeting pathologic necrosis due to its perceived uncontrollable nature. This notio | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| CALIFORNIA INSTITUTE OF TECHNOLOGY | $482,882 | Grant | Trans-NIH Recovery Act Research Support: Developing an understanding of the molecular mechanisms that underlie learning and memory stands as one of the central challenges of modern science. Our proposed studies will focus on a carbohydrate modification that plays a central role in this process: | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| KANSAS STATE UNIVERSITY | $47,336 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement will support three additional researchers for 10-12 weeks during the summer months of 2009 and 2010. In 2009 we will hire two undergraduates and another science educator. They will be trained in beetle husbandry and in all | Health and Human Services, Department of / National Institutes of Health | 6/23/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $315,122 | Grant | Trans-NIH Recovery Act Research Support: This grant is a supplement to the Sensory Experiences Project (R01-HD42168) to expand existing aims and accelerate scientific discoveries surrounding the heterogeneity, development and functional impact of sensory features in children with ASD. Sensory sy | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $231,000 | Grant | Trans-NIH Recovery Act Research Support: Over the last 4 years the parent grant (HD 44517) has been focused on improving our understanding of the pathophysiology of anesthesia-induced developmental neurodegeneration so that effective neuroprotective strategies can be developed. Our work, done wi | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| NEW YORK UNIVERSITY (INC) | $38,577 | Grant | Trans-NIH Recovery Act Research Support: Identification of All Functional Elements in Selected Model Organism Genomics | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| CALIFORNIA STATE UNIVERSITY, FULLERTON | $15,131 | Grant | Trans-NIH Recovery Act Research Support: To involve undergraduate students with potential interests in research careers in summer research and to train them for the workforce. It also would offer the opportunity for additional training and refreshment of science interests on the part of high s | Health and Human Services, Department of / National Institutes of Health | 6/24/2009 |
| UNIVERSITY OF WASHINGTON | $40,827 | Grant | Trans-NIH Recovery Act Research Support: The Kiss1 gene codes for a family of peptides called kisspeptins, which bind to a G protein-coupled receptor known as Kiss1r (also known as GPR54). Kisspeptin signaling through Kiss1r is essential for normal reproductive development and fertility. Kiss1 i | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $283,062 | Grant | Trans-NIH Recovery Act Research Support: Two additional age and sex matched comparison groups will be recruited? girls with mosaic (45X, 46XX) TS genotypes and Williams syndrome (WS). As girls with mosaic TS genotypes may have less severe cognitive problems relative to girls with TS due to X mo | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| RAND CORPORATION, THE | $348,889 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Religious congregations reach many lives and play an important role in working for social change. Could they play a similarly powerful role in the fight against HIV/AIDS? Although there is some evidence for an affirmat | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $213,224 | Grant | Trans-NIH Recovery Act Research Support: Brain development in the first two years of life is the most dynamic and perhaps the most important phase of postnatal brain development. In this time period there is a significant increase in overall brain size, with the brain reaching over 80% adult vo | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $119,603 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The birth of a child with a Disorder of Sex Development (DSD or intersexuality) can create a crisis for the newborn's family and healthcare professionals. Decisions about gender assignment, genital surgeries, and strat | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $744,988 | Grant | Trans-NIH Recovery Act Research Support: The Prenatal Cytogenetic Diagnosis by Array-Based Copy Number Analysis (aCNA) administrative supplement has goals consistent with ARRA funding guidelines. The supplement will: 1) create new geographically dispersed jobs for the entire 2 year period, 2) a | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF KENTUCKY | $232,934 | Grant | Trans-NIH Recovery Act Research Support: Project Summary Stroke is the leading cause of long-term disability in the United States. Approximately 70-88% of persons with stroke have some degree of motor impairment. A major goal of research in stroke rehabilitation is to harness the ability of the | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| WASHINGTON UNIVERSITY, THE | $124,517 | Grant | Trans-NIH Recovery Act Research Support: Preterm birth is a major public-health issue because of its increasing incidence combined with the frequent occurrence of subsequent behavioral, neurological, and psychiatric challenges faced by surviving infants. Resting state fcMRI is an ideal method to | Health and Human Services, Department of / National Institutes of Health | 9/26/2009 |
| RAND CORPORATION. THE | $40,870 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The prevalence of overweight and obesity among children and adolescents has been increasing dramatically with low-income and some racial/ethnic minority populations being at highest risk. Rising obesity rates and socio | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $238,730 | Grant | Trans-NIH Recovery Act Research Support: This application is a revised submission for a 5-year competitive continuation to grant 1R01-DA015269, Gender Identity and HIV Risk. The long-range goal of our research is to reduce HIV transmission among individuals stigmatized for their gender nonconfor | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $312,766 | Grant | Trans-NIH Recovery Act Research Support: We have established a powerful discovery strategy to determine critical gene function and to identify and prioritize candidate downstream genes. Our strategy comprises morpholino oligonucleotide (MO)-mediated, specific gene knockdown, validation of knock | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| CHILDREN'S RESEARCH INSTITUTE | $21,328 | Grant | Trans-NIH Recovery Act Research Support: This Supplement to Parent Grant 1R01HD058567; ?N-carbamylglutamate in the treatment of hyperammonemia? (PI Mendel Tuchman M.D.) was requested to provide employment opportunities for a undergraduate college student who is seeking to increase his/her resear | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| RAND CORPORATION. THE | $306,954 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Hurricane Katrina struck New Orleans, Louisiana, on the morning of August 29, 2005. The magnitude of the displacement that resulted was immense: the city's entire population of 455,000 was forced to leave the city and | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $8,473 | Grant | Trans-NIH Recovery Act Research Support: The approved summer student project seeks to investigate the role of TGF-+? in intestinal macrophage differentiation in transgenic mice that lack TGF-+? signaling. We had designed a set of sequential studies to investigate the hypothesis that the absence | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $45,900 | Grant | Trans-NIH Recovery Act Research Support: Community Partnerships for Child Safety: This project aims to prevent Injuries to Children in Baltimore City by building on ongoing community work: a) Johns Hopkins CARES (Children ARE Safe) mobile resource center; b) Baltimore City Fire Department neighb | Health and Human Services, Department of / National Institutes of Health | 6/24/2009 |
| UNIVERSITY OF NORTH DAKOTA | $29,160 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The overall goal of the present work is to characterize the cell and molecular mechanisms that regulate neural and vascular cell interactions during development. The central objective of this work is to determine the | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $12,500 | Grant | Trans-NIH Recovery Act Research Support: The CellsZcope is an automated instrument that allows for a more reliable monitoring of electrical integrity of cellular monolayers in real time. In addition, the paracellular permeability to solutes, another measure of integrity of brain endothelial mono | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | $66,843 | Grant | Trans-NIH Recovery Act Research Support: Dietary restriction extends lifespan, improves mid-life vigor, and retards age-related disease in many species. Mechanisms underlying these benefits are not well understood. Defining the cellular pathways by which dietary restriction is initiated and main | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $108,495 | Grant | Trans-NIH Recovery Act Research Support: Rickettsia felis is recognized as an emerging flea-borne rickettsial agent. Within the Specific Aims of the parent grant we have discovered a very interesting association between microbiota of fleas and their potential to transmit Rickettsia felis. Additi | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF CONNECTICUT | $1,337,447 | Grant | Trans-NIH Recovery Act Research Support: Two new investigators will be hired into tenure track positions (with a minimum funding for 4 years beyond the grant). The searches for these positions were pre-empted by a hiring freeze. Additional economic impact comes from two additional full-time tech | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF FLORIDA | $1,209,113 | Grant | Trans-NIH Recovery Act Research Support: The existing University of Florida Center for Smell and Taste (UFCST) will provide the basis for a Biomedical Research Core Center for Smell and Taste at the University of Florida (Core Center). The existing research infrastructure and environment of the | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF PITTSBURGH THE | $1,469,550 | Grant | Trans-NIH Recovery Act Research Support: The strategy was decided to build research capabilities on the existing tissue engineering strengths at the University of Pittsburgh which was lacking a concerted effort in the field of craniofacial regeneration. During its short history, CCR has been gro | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $850,000 | Grant | Trans-NIH Recovery Act Research Support: The identification and cloning of the CRAC channel by us and others (CRACM1/Orai1) has defined the basic molecular components required for store-operated calcium influx. Mutational analysis demonstrated that CRACM1/Orai1 homopolymerizes and that it consti | Health and Human Services, Department of / National Institutes of Health | 6/17/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $790,000 | Grant | Trans-NIH Recovery Act Research Support: Although chromosomal toxin-antitoxin (TA) systems have been known for some time in Gram- bacteria, TA modules in Gram+ species have been understudied. There are eight families of TA systems all of which operate under a similar principle, with a stable tox | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $639,650 | Grant | Trans-NIH Recovery Act Research Support: Mycolic acids and multimethyl-branched fatty acids are found uniquely in the cell envelope of pathogenic mycobacteria. These unusually long fatty acids are essential for the survival, virulence, and antibiotic resistance of Mycobacterium tuberculosis. Acy | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $883,957 | Grant | Trans-NIH Recovery Act Research Support: An enzyme that modifies sialic acid moieties known as Sialic acid acetyl esterase regulates the strength of signaling from the antigen receptor on B lymphocytes. Mutation of this gene in mice leads to enhanced B cell receptor signaling and autoimmunity - | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| VIRGINIA COMMONWEALTH UNIVERSITY | $492,613 | Grant | Trans-NIH Recovery Act Research Support: The goal of this proposal is to establish pre-clinical evidence of synergism between glucocorticoids such as dexamethasone (Dex) and the MEK inhibitors such as PD184352 in the induction of apoptosis in acute lymphoblastic leukemia (ALL | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| HEALTH RESEARCH, INC. | $717,229 | Grant | Trans-NIH Recovery Act Research Support: The aim of this funded R21 proposal is to study the role of dietary supplement selenium (Methylselenocysteine or MSC) in supranutritional doses in retarding cancer growth and synergistically enhancing chemotherapeutic efficacy in combination setting throu | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| WASHINGTON UNIVERSITY, THE | $600,094 | Grant | Trans-NIH Recovery Act Research Support: Patients with advanced cervical cancer are treated with chemoradiation. Pretreatment positron emission tomography (PET) with 18F- fluorodeoxyglucose (FDG) is routinely utilized for these patients to determine the extent of their disease, to aid in radiati | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC. | $412,966 | Grant | Trans-NIH Recovery Act Research Support: This proposal requests support to continue development of a Center of Biomedical Research Excellence in Protein Structure and Function (COBRE-PSF) at the University of Kansas. Our Center was established in October 2002, and includes participants from thre | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF ILLINOIS | $7,150 | Grant | Trans-NIH Recovery Act Research Support: The award was intended to provide supplemental funds to support a pre-dent undergraduate or prematriculating dental student for a summer research experience. The student was to participate in an ongoing research project supported by our parent grant that | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| ALBANY MEDICAL COLLEGE | $224,654 | Grant | Trans-NIH Recovery Act Research Support: The overall purposes of this administrative supplemental grant are (1) to increase the number of minority biomedical and behavioral scientists, and (2) to successfully accomplish the proposed experiments in the parent grant application. In the parent gra | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| THE VANDERBILT UNIVERSITY | $5,609 | Grant | Trans-NIH Recovery Act Research Support: Saphenous vein, mammary artery, and radial artery are all used as conduits for bypassing coronary artery stenoses. The focus in our laboratory is to develop methods to prevent vein graft failure. The current RO-1 proposal, ?Prevention of Vein Graft Failur | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $17,870 | Grant | Trans-NIH Recovery Act Research Support: The broad and long-term objective of this research project is to test the hypothesis that simultaneous sympathovagal discharges are the immediate triggers of paroxysmal atrial fibrillation (PAF) and that severing the connection between the autonomic nerve | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF KENTUCKY | $108,044 | Grant | Trans-NIH Recovery Act Research Support: Abnormal vascular smooth muscle cell (SMC) growth and migration contributes to hypertension, atherosclerosis, and restenosis. SMC function is controlled by complex regulatory mechanisms, which are governed in part by interactions with the extracellular ma | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERISTY OF MISSISSIPPI MEDICAL CENTER | $14,297 | Grant | Trans-NIH Recovery Act Research Support: Numerous epidemiological studies report an inverse relationship between birth weight and blood pressure suggesting that factors present in the fetal environment which affect fetal growth may result in permanent adaptive responses that lead to structural a | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $174,342 | Grant | Trans-NIH Recovery Act Research Support: Visceral sensory pathways that innervate the cardiovascular, respiratory and gastrointestinal systems are critical for reflex control of autonomic homeostasis. It is well established that functional characteristics of visceral reflexes, including arterial | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $215,093 | Grant | Trans-NIH Recovery Act Research Support: Pulmonary emphysema is a prevalent lung disease with no effective treatment. Its unique features are the ultimate disappearance of lung tissue and loss of alveoler-capillary units. The lung destruction becomes sustained and progressive even long after dis | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $205,192 | Grant | Trans-NIH Recovery Act Research Support: Title: Support for postdoctoral fellow Dr. Zongtian Tong. Award provides funds for salary and supplies to support a postdoctoral research fellow, Zongtian Tong. Dr. Tong's project will advance our understanding of the regulation of SREBP transcriptio | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $189,158 | Grant | Trans-NIH Recovery Act Research Support: Hematopoiesis has been extensively studied in many animal models, including mouse embryonic stem (ES) cells and murine embryos. However, analyses of human hematopoietic development typically utilize blood cells isolated from bone marrow or umbilical cord | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| UNIVERSITY OF ILLINOIS | $171,347 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement was used to hire a full-time employee (FTE) to assist NIH-RO1 funded principal investigator (PI). The research goals proposed for the new FTE was within the research scope of the parent grant at the level of the specific aim | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF CALIFORNIA, SANTA BARBARA | $36,433 | Grant | Trans-NIH Recovery Act Research Support: This grant provided a summer research experience for two undergraduate research assistants in health-related scientific research. | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| DEPARTMENT OF EDUCATION, SOUTH CAROLINA | $0 | Grant | Trans-NIH Recovery Act Research Support: Award rescinded by NIH due to investigator transfer. Principal investigator, Gary Wright, transferred from the Medical University of South Carolina to East Tennessee State University. Award revised to reflect a 1 day project period with $0.00 funding. | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY OF WASHINGTON | $243,429 | Grant | Trans-NIH Recovery Act Research Support: Disturbances in mineral metabolism are highly prevalent among older adults and may adversely impact cardiovascular health. In our NHLBI funded application, 'Mineral Metabolism and Cardiovascular Risk Among Older Adults (5R01HL084443-03),' we address the c | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $292,346 | Grant | Trans-NIH Recovery Act Research Support: Neutrophils are the most abundant cell type among circulating white blood cells and constitute the first line of host defense against invading bacteria and other pathogens. They are terminally differentiated cells and normally have a very short life-span | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $276,492 | Grant | Trans-NIH Recovery Act Research Support: Individuals live within a series of hierarchical environments, and these environments are associated with health and behaviors over and beyond individual level influences such as socioeconomic status or race. In many cases, these macro-level environmental | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| UNIVERISTY OF MISSISSIPPI MEDICAL CENTER | $217,856 | Grant | Trans-NIH Recovery Act Research Support: Superoxide plays an important pathophysiological role in the development of hypertension. Oxidative stress has been demonstrated in patients with essential hypertension, renovascular hypertension, malignant hypertension and preeclampsia, as well as in ex | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| SOUTH CAROLINA RESEARCH FOUNDATION | $150,700 | Grant | Trans-NIH Recovery Act Research Support: THE ROLE OF FLUID FLOW IN VALVULOGENESIS Early cardiac cushions are located in the atrioventricular canal (AV) of the embryonic heart. These cushions are populated with mesenchymal cells and are the primordia for the cardiac valves and membranous septa. A | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF ROCHESTER | $235,048 | Grant | Trans-NIH Recovery Act Research Support: A Ph.D. Candidate will work on the project to minimize delays in the project and will include, basic lab supplies, experiment reagents, and a data analysis workstation. | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $232,888 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this research is to develop methods for time resolved, low dose cardiac CT imaging. Specifically, we will develop algorithms that estimate the time-dependent motion vector field of the heart from the measured data and integrate it in | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF NEW MEXICO | $87,116 | Grant | Trans-NIH Recovery Act Research Support: Despite the origin of pulmonary arterial hypertension (PAH), pulmonary vascular resistance rises due to pulmonary vasoconstriction, arterial remodeling and polycythemia leading to right heart failure and death. Rodents exposed to chronic hypobaric hypoxia | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| THE VANDERBILT UNIVERSITY | $158,888 | Grant | Trans-NIH Recovery Act Research Support: Development of effective cell based therapies to mediate wound and cardiac regeneration is a national priority and has been identified as two Challenge Areas (11-GM-101 and 11-HL-101). Our funded R01 proposal addresses these challenge areas as it seeks to | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC. | $17,980 | Grant | Trans-NIH Recovery Act Research Support: An intact alveolar epithelial barrier is required for recovery from acute lung injury and ARDS, but the mechanisms for regulation of the alveolar barrier are not fully understood. Previous work in our laboratory has shown that the tight junction protein c | Health and Human Services, Department of / National Institutes of Health | 5/30/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $214,295 | Grant | Trans-NIH Recovery Act Research Support: This proposal seeks an administrative supplement to support the hiring of an additional study coordinator to enhance patient recruitment, collection of DNA, Plasma, and genotyping of patients in the Penn Heart Failure Study. This will allow us to achieve | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $10,168 | Grant | Trans-NIH Recovery Act Research Support: Neurotrophins affect airway smooth muscle tone. Air flows into the lungs through the conducting airways (trachea and bronchi) and, with every breath we take, the airways rhythmically contract and relax with each breath; this change in airway smooth muscle | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| GEORGIA HEALTH SCIENCES UNIVERSITY RESEARCH INSTITUTE, INC. | $237,850 | Grant | Trans-NIH Recovery Act Research Support: The main focus of this study is to characterize the cellular mechanisms underlying functional hyperemia in the cerebral cortex. Functional hyperemia occurs as a function of the communication between neurons, astrocytes and the cerebral microcirculation. D | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| BAYLOR COLLEGE OF MEDICINE | $208,180 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this grant is to develop a mouse model of pacing-induced chronic AF to elucidate the contribution of calcium channels in chronic atrial fibrillation. Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting about 2.5 millio | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $246,930 | Grant | Trans-NIH Recovery Act Research Support: These studies will lead to a more comprehensive understanding of how EpoR signals through JAK2 to regulate erythropoiesis, and how JAK2 mutations contribute to myeloproliferative disorders and lukemia. | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $275,284 | Grant | Trans-NIH Recovery Act Research Support: Diseases of the lung contribute to at least four of the top ten causes of death worldwide. In the United States alone, it is estimated that 11 million people are diagnosed with chronic obstructive lung disease and 24 million people have evidence of impair | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| BLOODCENTER OF WISCONSIN, INC. | $260,197 | Grant | Trans-NIH Recovery Act Research Support: Supplemental salary and equipment funds will be used to accelerate Aim 1 (of parent grant). The goal is to define the molecular mechanisms involved in inhibition of platelet activation and aggregation, which will contribute to a better understanding of pa | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $289,516 | Grant | Trans-NIH Recovery Act Research Support: This is an administrative supplement to an active R01 grant (1 R01 HL090975-01) funded by the NHLBI. The parent grant investigates the role of adiposity on vascular inflammation, immune cell activation, and neuroendocrine responses in 200 prehypertensive | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF NEVADA, RENO | $232,218 | Grant | Trans-NIH Recovery Act Research Support: Ion channels are pore-forming proteins that are present in the membranes of all cells. Ion channels control the flow of ions (and therefore electrical current) across the membrane of cells. The movement of ions across the cell membrane results in an elect | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $257,336 | Grant | Trans-NIH Recovery Act Research Support: These experiments will conclusively demonstrate or refute the importance of corin activity to the autocrine paracrine anti hypertrophic actions of the endogenous NPS, and provide biological confirmation for our previous genetic association studies that ha | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| COLORADO STATE UNIVERSITY | $152,830 | Grant | Trans-NIH Recovery Act Research Support: The luminal diameter of muscular arteries and arterioles of the microcirculation is the principal site of control of vascular resistance. These small blood vessels are significant regulators of blood pressure and local blood flow distribution, and impaire | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF FLORIDA | $240,256 | Grant | Trans-NIH Recovery Act Research Support: During hematopoiesis, the lineage-specific transcription programs are accompanied and maintained by appropriate patterns of active or repressive histone modifications. Epigenetic mechanisms play an important role in controlling stem cell potency and cell | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| NEW YORK UNIVERSITY (INC) | $240,366 | Grant | Trans-NIH Recovery Act Research Support: Early embryonic blood vessels form with great anatomical reproducibility to ensure homeostasis and survival. How the vasculature acquires its stereotypical architecture is poorly understood. To uncover the genetic and cellular basis of vascular patterning | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $219,574 | Grant | Trans-NIH Recovery Act Research Support: Pseudomonas aeruginosa is an important cause of serious infections in humans with a predilection for lung infections in the form of either acute pneumonia in hospitalized patients (usually associated with mechanical ventilation) or chronic pneumonia in pe | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $211,147 | Grant | Trans-NIH Recovery Act Research Support: The long term goal of this study is to understand how biological membranes control their structural integrity, dynamical response, and physiological performance. Here we specifically study the erythrocyte membrane which has a protein network coupled to a | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $168,107 | Grant | Trans-NIH Recovery Act Research Support: The parent grant originally planned to perform brain microdialysis experiments in collaboration with the Neurosciences Center at LSUHSC in New Orleans and therefore this equipment and the associated supplies were not budgeted in the application. However, | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF ROCHESTER | $261,365 | Grant | Trans-NIH Recovery Act Research Support: This supplemental request is focused on providing financial support for an additional post-doctoral fellow to accelerate the rate of scientific progress of the funded parent grant research. This 2 year supplement is requesting salary and research supply s | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF NEW MEXICO | $168,000 | Grant | Trans-NIH Recovery Act Research Support: Transposase activity was thought to be extinct in humans because DNA movement can be deleterious in higher organisms, resulting in genomic instability and perhaps malignancy. We isolated a human transposase protein termed Metnase that had preferential end | Health and Human Services, Department of / National Institutes of Health | 7/01/2009 |
| PURDUE UNIVERSITY | $69,066 | Grant | Trans-NIH Recovery Act Research Support: Innovative interdisciplinary work is essential to address the most challenging issues in the era of genomic biomedical research. One of these is the evolutionary structure/function of transcriptional regulation. Comparative molecular evolutionary work is | Health and Human Services, Department of / National Institutes of Health | 8/19/2009 |
| UNIVERSITY OF NEBRASKA | $95,017 | Grant | Trans-NIH Recovery Act Research Support: G-protein coupled receptors (GPCRs) are involved in various cellular signaling processes and activated by a diverse array of ligands. Many major diseases involve in malfunction of these receptors. Therefore, they are among the most important drug targets | Health and Human Services, Department of / National Institutes of Health | 7/28/2009 |
| UNIVERSITY OF CINCINNATI | $137,209 | Grant | Trans-NIH Recovery Act Research Support: Inadequate recruitment of eligible subjects for clinical trials is a major impediment to the advancement of medicine. Use of an EHR-based, point-of-care Clinical Trial Alert (CTA) approach has been shown to significantly improve recruitment in a prior stu | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF UTAH, THE | $43,660 | Grant | Trans-NIH Recovery Act Research Support: This award is issued in response to Notice OD-09-060, Recovery Act Administrative Supplements Providing Summer Research Experiences for Students and Science Educators. DESCRIPTION (provided by applicant): Selective manipulation of the function of nicotin | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| MICHIGAN STATE UNIVERSITY | $192,452 | Grant | Trans-NIH Recovery Act Research Support: Child Attention Deficit Hyperactivity Disorder (ADHD) represents a significant public health concern because it is common, costly, impairing, and chronic, placing children at substantial long-term risk. Since genetic and contextual factors are crucial to | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $291,941 | Grant | Trans-NIH Recovery Act Research Support: The long term goal of research in this lab is to understand how sensory experience during critical periods of development, mediated by the activity-driven functioning of circuits in the CNS, is translated into lasting structural change in synaptic connect | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $427,187 | Grant | Trans-NIH Recovery Act Research Support: In this administrative supplement we are requesting funds to increase the pace and achievement of scientific research of this project and to promote job creation. Specifically, we are requesting funds to provide the infrastructure to augment the analyses | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| CHILDRENS HOSPITAL OF PHILADELPHIA | $54,002 | Grant | Trans-NIH Recovery Act Research Support: The broad, long-term objectives of this work are to establish a practical and empirically-sound means to assess children's acute stress reactions after potentially traumatic events (eg, accidents, fires, disasters) and to expand our understanding of acute | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $18,670 | Grant | Trans-NIH Recovery Act Research Support: The parent grant is a R01 that funds a randomized controlled trial of the Fostering Healthy Futures preventive intervention for preadolescent children placed in out-of-home care as a result of abuse or neglect. The intervention is designed to promote chi | Health and Human Services, Department of / National Institutes of Health | 6/16/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $171,947 | Grant | Trans-NIH Recovery Act Research Support: This supplement will be used to conduct additional analyses relevant to the aims of the parent grant. we propose to address the following questions: 1) How do healthcare and education services complement or substitute for each other in different jurisdict | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO | $37,271 | Grant | Trans-NIH Recovery Act Research Support: While cross-sectional studies show that drug abuse, impulsivity, serotonin dysregulation, and stressful life events are associated with suicide, data regarding the specific relationships among these factors are limited. A recent NIDA-sponsored workgroup i | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $51,912 | Grant | Trans-NIH Recovery Act Research Support: Detection and Care for Depression in the Perinatal Period Major depressive disorder (MDD) among women in pregnancy and the postpartum can have profoundly negative implications for women; fetal, infant, and child development; and the larger family. This mi | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $347,167 | Grant | Trans-NIH Recovery Act Research Support: Project Summary/Abstract Neurological dysfunction is a significant complication of HIV disease. Despite the success of HAART in suppressing plasma HIV RNA, most antiretroviral drugs have poor CNS penetration and a reservoir of virus persists in brain. Thi | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| UNIVERSITY OF CHICAGO, THE | $116,759 | Grant | Trans-NIH Recovery Act Research Support: Neuronal nAChRs are composed of a number of subtypes as classified by their diverse pharmacology and distribution in the central and peripheral nervous system. We propose to study one such subtype, the neuronal a-bungarotoxin binding receptor (BgtR) in th | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $1,060,867 | Grant | Trans-NIH Recovery Act Research Support: Spinocerebellar ataxia type 1 (SCA1) is an untreatable fatal autosomal dominant neurodegenerative disorder caused by the expansion of a glutamine repeat within the SCA1-encoded protein ATXN1. Previous work showed that ATXN1 is modified by phosphorylation | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF KENTUCKY | $112,794 | Grant | Trans-NIH Recovery Act Research Support: Fairness of skin correlates with diminished epidermal expression of eumelanin, the brown/black pigment responsible for dark complexion. Instead, there is preferential expression of pheomelanin, a sulfated blonde/red melanin species that is soluble and has | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| THE WASHINGTON UNIVERSITY | $49,434 | Grant | Trans-NIH Recovery Act Research Support: Matrix metallo-proteinases (MMPs) are often present in high levels in cancer such as tumors of the skin, breast, thyroid, cervix, lung, colon and prostate, but absent in normal tissues. MMPs are enzymes that are capable of chewing through the protein barr | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $51,972 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this project is to develop new functional EPR probes of enhanced stability for in vivo EPR spectroscopy and imaging of pH, one of the most important parameters in the biochemistry of living organisms. pH-sensitive nitroxyl radicals hav | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $743,251 | Grant | Trans-NIH Recovery Act Research Support: Formaldehyde is an important industrial chemical to which millions of workers are exposed worldwide. Environmental exposures can also be significant as a result of off-gassing in new mobile homes and from combustion. The International Agency of Research | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| BAYLOR COLLEGE OF MEDICINE | $782,975 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this grant is to study the regulation of the ocular surface immune response to desiccating stress.Sj+?grenG??s syndrome causes profound dysfunction of the lacrimal functional unit (LFU) that results in decreased secretion of tear fluid and | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY OF PITTSBURGH THE | $1,453,652 | Grant | Trans-NIH Recovery Act Research Support: This project aims to support the hiring of a new tenure track Assistant Professor to perform research on vascular disease and pulmonary hypertension complications in patients with systemic sclerosis (SSc) in an interdisciplinary environment, focusing on t | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF ROCHESTER | $801,398 | Grant | Trans-NIH Recovery Act Research Support: The purpose of the American Recovery and Reinvestment Act of 2009 is to create jobs, and for NIH awards to fund science in pursuit of improving the length and the quality of the lives of U.S. citizens, while at the same time stimulating the economy. This | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| RHODE ISLAND HOSPITAL | $25,918 | Grant | Trans-NIH Recovery Act Research Support: Pediatric asthma is increasingly common among minority children, and results in considerable health care disparity. The parent grant G??Community Partnerships to Reduce Asthma DisparitiesG?? (R01 NR08524, E. McQuaid, PI) established a Community Partnersh | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| BAYLOR COLLEGE OF MEDICINE | $178,420 | Grant | Trans-NIH Recovery Act Research Support: Purpose: To understand and prevent seizure-induced learning and memory deficits in children with severe epilepsy. Abstract: The studies proposed in our original application are based on the premise that recurring seizures in early-life contribute to cog | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $0 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this proposal is to expand the capabilities of the Center for Experimental Neurorehabilitation Research Training (CENT) by adding a desktop scanning electron microscope (EM) capability to our micro imaging armamentarium. The laboratory of | Health and Human Services, Department of / National Institutes of Health | 9/26/2009 |
| CHILDREN'S RESEARCH INSTITUTE | $10,664 | Grant | Trans-NIH Recovery Act Research Support: The NCMRR Center at Children?s National Medical Center provides a broad array of services to medical rehabilitation researchers nationwide, including DNA (genotyping, sequencing), mRNA profiling, and proteomics assays, as well as database design and imple | Health and Human Services, Department of / National Institutes of Health | 7/09/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $563,242 | Grant | Trans-NIH Recovery Act Research Support: Community Approaches to Cardiovascular Health: Pathways to Heart Health (CATCH-PATH) proposes to implement and evaluate a community-based participatory research (CBPR) intervention designed to reduce and ultimately eliminate disparities in cardiovascular | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $88,771 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Organelle movement is a hallmark of cell division and cellular differentiation. In every cell-type, the localization, number and morphology of each type of organelle is modified to achieve specific cellular functions. | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $71,102 | Grant | Trans-NIH Recovery Act Research Support: We propose an Administrative Supplement, under the Recovery Act (NOT-OD-09-056), to parent grant, NIH R37 HD025594, 'Cell Motility and Cell Interactions During Neurulation. The work proposed here will greatly accelerate and extend the progress, and enhanc | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $48,339 | Grant | Trans-NIH Recovery Act Research Support: Since the passage of landmark welfare reform legislation in 1996, considerable attention has been paid to the impact of the time-limited benefits, sanctions, and work requirements of the law, as well as its overall impact, on economic and demographic outc | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| NEW YORK UNIVERSITY | $62,021 | Grant | Trans-NIH Recovery Act Research Support: This study could provide evidence that neuronal Cdh1 activity helps prevent the onset of Alzheimer's disease by maintaining neurons in a post-mitotic state by preventing cell cycle reentry which would lead to neuronal death. Understanding both the regulat | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $60,521 | Grant | Trans-NIH Recovery Act Research Support: The goal of the proposed project is to investigate how the aged brain responds to skilled motor training, both before and after stroke-like brain injury. This will be accomplished by first determining differences in behavior and neural plasticity in intac | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| NEW YORK UNIVERSITY (INC) | $19,763 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Dendritic cells (DCs) within peripheral tissues play a critical role in initiating immune responses towards peripheral antigens. Upon activation, these cells migrate through the tissue stroma towards lymphatic vessels, | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY | $60,628 | Grant | Trans-NIH Recovery Act Research Support: La Crosse encephalitis virus (LAC), a devastating neurologic disease in children living in endemic areas like West Virginia and southwestern Virginia, is maintained through interactions between mosquito vectors and non-human vertebrate reservoir hosts in | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| BROWN UNIVERSITY IN PROVIDENCE IN STATE OF RI AND PROVIDENCE PLANTATIONS | $57,176 | Grant | Trans-NIH Recovery Act Research Support: The host response against microbial pathogens consists of the integrated actions of both the innate and adaptive immune systems. Protective immunity to viruses is dependent upon the complex interactions between cytokines and chemokines to regulate both in | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF CALIFORNIA MERCED | $63,771 | Grant | Trans-NIH Recovery Act Research Support: Effects of a Chlamydial ATP Consuming Enzyme on the Inflammasome: This funding supports the tuition, benefits and stipend for two years of a graduate students expenses thereby, providing enough support for the completion of a PhD in Quantitative Systems | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $67,396 | Grant | Trans-NIH Recovery Act Research Support: My research project aims to study host-pathogen interactions by identifying host factors that interact with and, consequently, restrict viruses. Through a combination of genomics, evolutionary biology and virology, we can predict specific host factors tha | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO | $111,304 | Grant | Trans-NIH Recovery Act Research Support: Astrocytes play a fundamental role in signaling, maintenance and protection of the brain. Data generated in the sponsor's laboratory suggest that the neuroprotective ability of astrocytes diminishes with age. It was also discovered that the purinergic rec | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| CORNELL UNIVERSITY, INC | $109,120 | Grant | Trans-NIH Recovery Act Research Support: Recently, cerebral microvessel disease has been identified as an important component of Alzheimer's disease. The mechanism of interaction between the diseases is still unclear in part because animal models of microvascular disease are lacking. The propose | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF ILLINOIS | $1,362,875 | Grant | Trans-NIH Recovery Act Research Support: The aims of this two year grant were: 1) to develop instruments, utilizing focus groups representing both genders and diverse racial/ethnic groups, to delineate the domains of salient current macro level stressors (MLS), the nature and intensity of exposu | Health and Human Services, Department of / National Institutes of Health | 5/22/2009 |
| UNIVERSITY OF WASHINGTON | $50,054 | Grant | Trans-NIH Recovery Act Research Support: Acute inflammation is a self-limiting response driven by the cells of the innate and adaptive immune systems that serves to rid the body of invading pathogens. Chronic inflammation on the other hand, represents an immune response that fails to resolve. Un | Health and Human Services, Department of / National Institutes of Health | 7/23/2009 |
| THE CHILDREN'S HOSPITAL OF PHILADELPHIA | $18,387 | Grant | Trans-NIH Recovery Act Research Support: Dendritic cells (DCs) are potent antigen presenting cells (APCs) due to the ability to stimulate nai've T cells with antigen. DCs are also a promising new source of vaccine development. Endocytosis and migration are two key processes in the ability of DCs | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| THE VANDERBILT UNIVERSITY | $109,144 | Grant | Trans-NIH Recovery Act Research Support: Respiratory syncytial virus (RSV) is a major etiologic agent of lower respiratory tract infection in children and the elderly. In the U.S., RSV can be detected in 43% of pediatric patients hospitalized with bronchiolitis and 25% with pneumonia. Neonates h | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | $100,084 | Grant | Trans-NIH Recovery Act Research Support: A T cell response is initiated by T cell receptor (TCR) activation through recognition of foreign antigen displayed on the surface of an antigen presenting cell (APC) and results in the directional secretion of certain cytokines or cytolytic factors towar | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $99,356 | Grant | Trans-NIH Recovery Act Research Support: Clostridium difficile is a bacteria that causes epidemic disease throughout the United States and has become a major public health concern in health care facilities and the community. Understading the ways in which C. difficile causes disease by describin | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| GLOBAL VACCINES INC | $97,684 | Grant | Trans-NIH Recovery Act Research Support: Effect of a viral replicon adjuvant on dendritic cell activity. It has been demonstrated in this lab that infectious, non-propagating replicon particles from Venezuelan equine encephalitis virus (VEE) act as an adjuvant when co-delivered parenterally wit | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $97,684 | Grant | Trans-NIH Recovery Act Research Support: This proposal aims to test the hypothesis that specific trafficking mechanisms target pulmonary memory lymphocyte homing to lung, and to identify the adhesion and chemoattractant receptors involved. Published studies are consistent with lung-selective | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $3,974,096 | Grant | Trans-NIH Recovery Act Research Support: he central theme of the Program Project is to understand the innate host defense mechanisms against inhaled pathogens by the two pulmonary collectins, surfactant proteins A and D (SP-A, SP-D). This understanding is important not only in the context of pre | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| THE VANDERBILT UNIVERSITY | $977,250 | Grant | Trans-NIH Recovery Act Research Support: Human genetic research has made remarkable progress in understanding the underlying genetic architecture of numerous human genetic traits. The underlying genetic lesions for thousands of Mendelian traits have now been identified and hundreds of associati | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $887,916 | Grant | Trans-NIH Recovery Act Research Support: Mycobacterium tuberculosis (Mtb) grows in human macrophages, the principal host cell, where it occupies a niche allowing it to replicate without being recognized by the host. Attenuated Mtb induce apoptosis of the host macrophages resulting in containment | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| BOSTON MEDICAL CENTER CORPORATION | $833,634 | Grant | Trans-NIH Recovery Act Research Support: Successfully eradicating HIV infection will require understanding how cellular reservoirs that poorly express virus are established and maintained, as well as determining whether these populations can be purged of HIV. This proposal focuses on the biochem | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| MEDICAL COLLEGE OF WISCONSIN, INC., THE | $760,000 | Grant | Trans-NIH Recovery Act Research Support: he objective of this application is to understand the mechanisms responsible for coronary sclerosis and cardiac dysfunction induced by total body irradiation (TBI), and to identify and develop medical countermeasures to mitigate and/or treat such injury. | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $762,608 | Grant | Trans-NIH Recovery Act Research Support: To carry out their immunological function, lymphocytes must travel to specific locations within the body. The homing of lymphocyte sublines is controlled through a complex molecular zipcoding, in which surface receptors on lymphocytes bind ligands on bloo | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $2,216,397 | Grant | Trans-NIH Recovery Act Research Support: The goal of this proposal is to change this landscape in Trypanosoma cruzi drug development. We propose the development of a consortium of academic laboratories and pharmaceutical companies who will investigate a variety of independently identified drug | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $949,500 | Grant | Trans-NIH Recovery Act Research Support: This project will explore the activation of human endogenous retroviruses (HERVI to induce immunity to HIV-1 and prevent or ameliorate infection. Small molecules capable of activating HERV expression will be identified, and their ability to stimulate immu | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $677,925 | Grant | Trans-NIH Recovery Act Research Support: Excessive exposure to manganese results in basal ganglia pathology and enhanced production of inflammatory mediators (cytokines, nitric oxide, prostaglandins) by activated glia in vitro. At present, there are no in vivo studies describing the nature of | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| UNIVERSITY OF OKLAHOMA | $754,275 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this proposal is to investigate the role of protein tyrosyl-sulfation in normal retinal function. The intermediate aims include the identification of retinal proteins that are sulfated by tyrosylprotein sulfotransferases and determine | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF MIAMI | $747,102 | Grant | Trans-NIH Recovery Act Research Support: Two million people are visually impaired by glaucoma in the US. Glaucoma causes progressive dysfunction and death of retinal ganglion cells (RGCs) resulting in blindness. Our long-term goal is to prevent RGC death in the early stages of glaucoma and spare | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $732,880 | Grant | Trans-NIH Recovery Act Research Support: Glaucoma is the second leading cause of blindness in the United States. Understanding how retinal ganglion cell (RGC) susceptibility to degeneration is modulated by the major risk factor, elevation of intraocular pressure (IOP), as well as other factors, | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $384,908 | Grant | Trans-NIH Recovery Act Research Support: The proper control of cell migration is critical for metazoan development. Directed migration requires secreted extracellular signals that act through cell surface receptors to guide the migrations of those cells. Secreted Wnt proteins are members of a ma | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| THE VANDERBILT UNIVERSITY | $576,658 | Grant | Trans-NIH Recovery Act Research Support: Circadian clocks are self-sustained biochemical oscillators that underlie daily rhythms of sleep/waking, metabolic activity, gene expression, and many other biological processes. Their properties include temperature compensation, a time constant of approx | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE | $575,080 | Grant | Trans-NIH Recovery Act Research Support: The proposed research will further develop a new mass spectrometric technique to examine protein structure and dynamics via the attachment of residue specific noncovalent probes. The technique is referred to as selective noncovalent adduct protein probing | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| NORTH CAROLINA STATE UNIVERSITY | $620,764 | Grant | Trans-NIH Recovery Act Research Support: Revised Abstract Section TAK1 kinase is an indispensable intermediate in the intracellular signaling of innate immune responses. TAK1 is activated by many of distinct factors including Toll-like receptor ligands, intracellular microorganism sensor (NOD l | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $6,048 | Grant | Trans-NIH Recovery Act Research Support: The Inferior Colliculus as a Site of Electrical Stimulation ARRA | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| SANARIA INC. | $1,987,012 | Grant | Trans-NIH Recovery Act Research Support: Attenuated Sporozoite Malaria Vaccine | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF IOWA, THE | $648,648 | Grant | Trans-NIH Recovery Act Research Support: Nontypeable Haemophilus influenzae (NTHi) commonly colonize the mucosal surfaces of the human upper respiratory tract. For the most part, this species resides in that environment in a benign (symbiotic?) relationship with the human host. With pathophysi | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $380,818 | Grant | Trans-NIH Recovery Act Research Support: The long term goal of this project is to elucidate the roles protein arginine methylation in Trypanosoma brucei gene expression, particularly at the RNA level. These studies will greatly increase our understanding of gene regulation in a medically and eco | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $185,000 | Grant | Trans-NIH Recovery Act Research Support: This is a supplement to the parent grant R01 DK068036, which is entitled Molecular Mechanism of IKK in FFA-associated Insulin Resistance. In the studies of parent project, we found a significant activity of NF-kB in the induction of energy expenditure. | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | $630,000 | Grant | Trans-NIH Recovery Act Research Support: BK-type calcium-activated potassium channels serve as cytoplasmic Ca2+ detectors that can rapidly respond to and modulate transmembrane voltage. These channels are critical in controlling action potential firing in neurons as well as smooth muscle contrac | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE | $50,000 | Grant | Trans-NIH Recovery Act Research Support: I have received an NIH/NIA Mentored Research Scientist Development Award (K01) to support my growth into an independent investigator whose research focuses on the neurobiological underpinnings of cognitive aging. Two studies will investigate the role of | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $938,866 | Grant | Trans-NIH Recovery Act Research Support: Uveitis is a major cause of blindness. Anterior uveitis is approximately four times as common as posterior uveitis. Endotoxin-induced uveitis, a model first described by the PI nearly 30 years ago, has been a valuable tool to understand acute inflammation | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $616,291 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of the proposed research is to understand how ErbB signaling regulates Abl/Arg and Src to control cell morphology, adhesion and movements during vertebrate development. Xenopus gastrulation will be used as the model system. ErbB signali | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $549,556 | Grant | Trans-NIH Recovery Act Research Support: Cytochrome COxidase (CcO) is an important enzyme involved in the electron transfer pathway in cellular respiration. CcO activates molecular oxygen to prevent the release of potentially toxic oxygen intermediates and at the same time, uses the free energy | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| INDIANA STATE UNIVERSITY | $629,968 | Grant | Trans-NIH Recovery Act Research Support: Most behavioral traits have complex bases and are the result of interactions between multiple genes and/or environments. Therefore, advancing our knowledge of human behavior will require an understanding of the genetic, epigenetic, and environmental bases | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF TEXAS AT DALLAS | $474,132 | Grant | Trans-NIH Recovery Act Research Support: The central hypothesis of this proposal is that cysteine is a significant cause of oxidative stress without oxygen, and that reactive sulfur species (RSS) mediate this stress. Because some of the most notorious pathogens have a particular enzyme to mainta | Health and Human Services, Department of / National Institutes of Health | 7/31/2009 |
| OREGON STATE UNIVERSITY | $555,560 | Grant | Trans-NIH Recovery Act Research Support: Myosins are the molecular motors essential for the viability of eukaryotic cells. In particular, non-muscular class V myosins are required for the inheritance, positioning, and transport of organelles in yeast, animals, and humans, whereas plants possess | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TEXAS A & M RESEARCH FOUNDATION | $105,194 | Grant | Trans-NIH Recovery Act Research Support: Prior research has shown that neurons within the spinal cord can support some simple forms of learning. Learning in the isolated spinal cord can be studied by cutting communication with the brain by means of a thoracic transection. Transected rats given s | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $847,500 | Grant | Trans-NIH Recovery Act Research Support: The proposed experimental plan is an extension of our previous study aimed at defining the histone modifications responsible for the differentiation of progenitors into oligodendrocytes, the myelin-forming cells of the central nervous system. In the paren | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| BROWN UNIVERSITY IN PROVIDENCE IN STATE OF RI AND PROVIDENCE PLANTATIONS | $79,704 | Grant | Trans-NIH Recovery Act Research Support: The initial event in the life cycle of a virus is its interaction with receptors present on the surface of a cell. Understanding these interactions is important to our understanding of viral tropism, spread, and pathogenesis. The human polyomavirus, JCV, | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $109,913 | Grant | Trans-NIH Recovery Act Research Support: This award sustains and extend the characterization of parkin interacting substrates. In particular this supplement is allowing the continuation of important studies focused on the identification and characterization of the Parkin Interacting Substrate (P | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $80,216 | Grant | Trans-NIH Recovery Act Research Support: During this period, we made good progress on completing the objectives of R000272. We: (1) used a BioTek-2 plate reader to establish a full time course of cell death (immediately-2 days post injury) at varying levels of injury (moderate to severe); (2) we | Health and Human Services, Department of / National Institutes of Health | 8/15/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $42,092 | Grant | Trans-NIH Recovery Act Research Support: One long term objective is to understand the biochemical and cellular mechanisms of the regulation of the sodium pump (Na,K-ATPase), which is the driving force for cerebrospinal fluid (CSF) secretion. The other is to understand how that regulation is coor | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $8,528 | Grant | Trans-NIH Recovery Act Research Support: ARRA Summer Research Experience: Student | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $181,220 | Grant | Trans-NIH Recovery Act Research Support: Our recent studies have demonstrated that conventional isoforms of protein kinase C (PKC) are key signaling components in the pathways that mediate the inhibitory activities of both myelin components and astrocyte-derived chondroitin sulfate proteoglycans | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| CREIGHTON UNIVERSITY | $132,572 | Grant | Trans-NIH Recovery Act Research Support: Determine if the superinfecting HY TME agent persists in animals when blocked by prior infection with the DY TME agent. Determine if HY TME agent emergence is inevitable. The data generated will further refine the parameters of prion strain interferenc | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| REHABILITATION INSTITUTE OF CHICAGO | $58,030 | Grant | Trans-NIH Recovery Act Research Support: This award is issued in response to Notice OD-09-060, Recovery Act Administrative Supplements Providing Summer Research Experiences for Students and Science Educators.One of the most pervasive problems for stroke survivors is movement deficits. Recent res | Health and Human Services, Department of / National Institutes of Health | 7/24/2009 |
| UNIVERSITY OF ROCHESTER | $29,568 | Grant | Trans-NIH Recovery Act Research Support: The overall purpose of the award is to employee two undergraduate summer students to give them experience within a laboratory environment to help in the educational experience and to collect data relevant to the Aims of the parent award. | Health and Human Services, Department of / National Institutes of Health | 7/19/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $177,830 | Grant | Trans-NIH Recovery Act Research Support: Our long term aim is to use a genetic approach in Drosophila to understand molecular mechanisms of motorneuron fate specification and differentiation. In this proposal, we focus on mechanisms linking motorneuron fate to axon guidance. In a large-scale scr | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $121,352 | Grant | Trans-NIH Recovery Act Research Support: Our studies supported by the parent R01 grant have identified a novel ion channel complex that controls neuronal excitability and may be involved in pathophysiological conditions such as apnea, paralysis, seizure and epilepsy. The requested funding will | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| UNIVERSITY OF MIAMI | $44,627 | Grant | Trans-NIH Recovery Act Research Support: Spinal cord injury (SCI) is a devastating condition which results in lifelong disability. To date there exists no treatment that can restore significant function to persons with SCI. We have previously demonstrated that a combinatory strategy of Schwann c | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY OF IOWA, THE | $143,776 | Grant | Trans-NIH Recovery Act Research Support: Mitochondria provide energy, buffer calcium, and sequester cell death-inducing molecules, and mitochondrial dysfunction is implicated in various neuropathologies. Especially in neurons, mitochondria are highly dynamic organelles that constantly move, divi | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| WAKE FOREST UNIVERSITY | $238,378 | Grant | Trans-NIH Recovery Act Research Support: Diabetes is a risk factor for cerebrovascular disease, cognitive impairment, and related dementia. Data derived from populations suggest that several comorbidities of diabetes increase the risk for cognitive impairment, structural brain changes associated | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $199,278 | Grant | Trans-NIH Recovery Act Research Support: To date, this supplement has helped stimulate the U.S. economy by providing funds for the hiring of Dr. Antoine Muchir as an Associate Research Scientist at Columbia University. The hiring of Dr. Muchir as well as additional funds for supplies as part of | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF MIAMI | $44,628 | Grant | Trans-NIH Recovery Act Research Support: The overall purpose of the award is to provide undergraduate students with experience in an NIH-funded biomedical research lab. In addition to the obvious goal of giving summer jobs to deserving young people, There are two major goals. First, to teach stu | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY OF CINCINNATI | $33,158 | Grant | Trans-NIH Recovery Act Research Support: Depression is a highly prevalent in Parkinson's disease (PD) and is often said to contribute more to the lowered quality of life than the debilitating motor symptoms. Although the etiology of depression in PD is unknown, understanding the potential pathop | Health and Human Services, Department of / National Institutes of Health | 7/19/2009 |
| THE WASHINGTON UNIVERSITY | $34,308 | Grant | Trans-NIH Recovery Act Research Support: Our previous work suggests that the protein 'Sunday Driver' (syd) organizes a damage surveillance system in peripheral neurons. In this proposal, we will further test the role of syd in conveying vesicle packages and signaling molecules along axons from t | Health and Human Services, Department of / National Institutes of Health | 7/27/2009 |
| BRANDEIS UNIVERSITY | $34,906 | Grant | Trans-NIH Recovery Act Research Support: Rett Syndrome is a devastating developmental disorder due in most cases to mutation of the gene Mecp2. Affected individuals lose or fail to develop many normal language, motor and cognitive abilities. Mutant mice lacking part or all of the gene recapitula | Health and Human Services, Department of / National Institutes of Health | 7/19/2009 |
| DUKE UNIVERSITY | $412,001 | Grant | Trans-NIH Recovery Act Research Support: The central question of the parent award is to understand the relationship between cortico-striatal synaptic function and pathological behaviors. The initial step toward this was to understand the striatal synaptic defects created by deletion of the SAPAP | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $293,496 | Grant | Trans-NIH Recovery Act Research Support: Bacterial pneumonia continues to be a leading cause of death and warrants improved treatment strategies. Recruitment of neutrophils into the lungs is one of the most important defense mechanisms in the initial host defense against bacterial infection. How | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF OREGON | $219,967 | Grant | Trans-NIH Recovery Act Research Support: Recognizing their advantages for comparative medicine, NIH supports a substantial amount of research on teleost fish, including zebrafish, medaka, stickleback, and others. Teleost models of human disease provide distinct advantages for analyzing vertebrat | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| THE TRUSTEES OF DAVIDSON COLLEGE | $66,826 | Grant | Trans-NIH Recovery Act Research Support: Adolescence marks a critical period in development in which individuals are particularly vulnerable to developing problems with substance abuse and dependence. Using an animal model, we will examine the effects of social contact with a companion with acce | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| CALVIN COLLEGE | $55,077 | Grant | Trans-NIH Recovery Act Research Support: A supplement is requested to our current grant Biophysical Analysis of Enzyme-Inhibitor Interactions (1R15GM073662-01). The supplement will allow us to: 1) identify primarily single molecule rupture events between carbonic anhydrase enzyme and a tethered | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $30,102 | Grant | Trans-NIH Recovery Act Research Support: Over 4 million individuals were newly infected with HIV in 2006 with sexual transmission the predominant mode of infection worldwide, highlighting the need for effective prevention strategies. Unfortunately clinical trials to date, with the first generati | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| LOYOLA UNIVERSITY | $31,838 | Grant | Trans-NIH Recovery Act Research Support: The overall purpose of this award is to support undergraduate summer research regarding how respiratory viruses cause inflammation. By identifying host factors leading to inflammation upon virus infection, novel therapies to reduce the extent of viral di | Health and Human Services, Department of / National Institutes of Health | 7/23/2009 |
| LOYOLA UNIVERSITY | $31,838 | Grant | Trans-NIH Recovery Act Research Support: This award is to support undergraduate summer students. The undergraduates perform research associated with parent grant AI082509 entitled Ubiquitin and Cellular Factors in Coronavirus Assembly. The goals of the project are to provide mentorship to unde | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| DUKE UNIVERSITY | $78,000 | Grant | Trans-NIH Recovery Act Research Support: NOT-OD-09-058: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Application The immune system has the potential to eliminate altered neoplastic cells with incredible specificity. A consistent in-frame deletion in the extra-cel | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $0 | Grant | Trans-NIH Recovery Act Research Support: Award deobligated because PI did not hire named person on the diversity supplement. | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF SOUTH FLORIDA | $1,462,240 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Increasing numbers of persons who have co-occurring mental and substance use disorders (CODs) and other health-related conditions are involved in the criminal justice system, and have placed an enormous strain on insti | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $1,574,637 | Grant | Trans-NIH Recovery Act Research Support: The University of Southern California (USC) P30 project is directed at recruiting junior faculty members whose research interests are complementary to our goal of enhancing our understanding of the polydisciplinary events shaping craniofacial morphogenesi | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| OAKLAND UNIVERSITY | $722,226 | Grant | Trans-NIH Recovery Act Research Support: The goal of this award is to develop a Core Center in Quantitative Biology at Oakland University. To strengthen this Core Center, a new faculty member will be recruited to perform interdisciplinary and translational research. This Core Center will build o | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF MISSOURI SYSTEM | $754,973 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This proposal aims to strengthen the biophysics core at the University of Missouri comprised of the Department of Physics and Astronomy, the Dalton Cardiovascular Research Center, and the Biochemistry Department by hir | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF SOUTH FLORIDA | $1,329,000 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This proposal seeks support for new faculty recruitment to enhance research resources for the Nanomedicine Research Center (NRC) at the University of South Florida College of Medicine, whose mission is to serve as a ca | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| NEW YORK UNIVERSITY (INC) | $1,553,738 | Grant | Trans-NIH Recovery Act Research Support: Cardiovascular disease is a leading cause of morbidity and mortality, accounting for upwards of 900,000 deaths annually in our country and many millions more worldwide. NYU School of Medicine has identified improved cardiovascular health as one of its key | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $1,398,000 | Grant | Trans-NIH Recovery Act Research Support: This goal of this grant is to recruit a talented new faculty member that would enrich the collaborative group of dynamic cardiovascular research faculty and trainees at UC Davis that crosses several departments and colleges. | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| DUKE UNIVERSITY | $779,421 | Grant | Trans-NIH Recovery Act Research Support: The broad, long-term objective of the proposed research is to elaborate an approach for a comprehensive analysis of data on health-related changes in aging individuals by developing tools for integrative analyses of distinct types of longitudinal data and | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF MARYLAND BALTIMORE COUNTY | $1,022,237 | Grant | Trans-NIH Recovery Act Research Support: This project will focus on the triad of relationships among the older surviving mother, a focal adult child, and the child's sibling, six to nine months after the death of an elderlyfather. The focus will be on the cultural meaning and the processes of be | Health and Human Services, Department of / National Institutes of Health | 8/15/2009 |
| UNIVERSITY OF PITTSBURGH THE | $451,155 | Grant | Trans-NIH Recovery Act Research Support: Using a longitudinal design we will examine two objectives. Objective 1 is to determine the impact of the Medicare Part D drug benefit intervention on racial differences in the use of lipid lowering medications in those with IHD (i.e., a history of MI | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $675,950 | Grant | Trans-NIH Recovery Act Research Support: The quality of care delivered to frail elders residing in nursing homes remains an important and perplexing issue in American health policy. Given the preferential tax treatment afforded nonprofit firms, there has been much interest among policymakers and | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $767,500 | Grant | Trans-NIH Recovery Act Research Support: Caloric restriction (CR) extends life-span and delays diseases in animal models. This remarkable observation has been difficult to translate into human health benefits, for two primary reasons. First, a life-time of food deprivation and reduced body weigh | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $801,605 | Grant | Trans-NIH Recovery Act Research Support: Drug Targets for Tuberculosis. Despite the availability of antibiotics, tuberculosis remains a major cause of death worldwide. Current drugs, while effective and inexpensive, are quite difficult to administer because of the very extended courses of treatm | Health and Human Services, Department of / National Institutes of Health | 5/12/2009 |
| UNIVERSITY OF ROCHESTER | $916,778 | Grant | Trans-NIH Recovery Act Research Support: Semen contains cationic amyloid fibrils derived from proteolytic cleavage fragments of prostatic acid phosphatase (PAP) that efficiently capture HIV-1 particles. These fibrils have been termed semen-derived enhancer of viral infection (SEVI) and enhance H | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| UNIVERSITY OF OKLAHOMA | $1,000,729 | Grant | Trans-NIH Recovery Act Research Support: It's not often said but it must be admitted: current therapy for polyarticular juvenile idiopathic arthritis (JIA) is little more than an exercise in 'chasing failure.' That is, medications are added or doses adjusted only after a child has failed to resp | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| UNIVERSITY OF ARIZONA | $302,084 | Grant | Trans-NIH Recovery Act Research Support: There are few published data concerning the induction and maintenance of immune tolerance based on concurrent clinical and mechanistic studies in rheumatoid arthritis (RA). It is of critical importance to understand the mechanisms of the induction of tole | Health and Human Services, Department of / National Institutes of Health | 8/12/2009 |
| UNIVERSITY OF MARYLAND | $758,231 | Grant | Trans-NIH Recovery Act Research Support: Costameres are structures at the surface of striated muscle that align the sarcolemma regularly with nearby myofibrils and transmit contractile force laterally, through the membrane to the extracellular matrix. Costameres must therefore be linked to nearb | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF IOWA, THE | $580,999 | Grant | Trans-NIH Recovery Act Research Support: Multiple myeloma (MM) is still incurable - causing the death of 10,000 Americans annually. Currently, glucocorticoids and the proteasome-inhibiting drug PS-341 (Bortezomib/Velcade) rank among the most effective agents in myeloma therapy. Given that MM is | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $637,233 | Grant | Trans-NIH Recovery Act Research Support: Epstein Barr virus nuclear antigen EBNA3C is a latent viral nuclear antigen essential for B cell transformation in vitro. This EBV antigen has been linked to the specific regulation of a number of cellular events which include regulation of transcription, | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $501,025 | Grant | Trans-NIH Recovery Act Research Support: Dramatic advances in cancer treatment will depend on identifying new targets for therapeutics. Here we propose as a candidate target a novel phosphoinositide signaling pathway that we have discovered. We have identified a pathway involving the phosphoinos | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $614,200 | Grant | Trans-NIH Recovery Act Research Support: SWI/SNF complex loss facilitates gene silencing during NSCLC development. Epigenetic changes in gene expression play an important role in the development and progression of human non-small cell lung carcinoma (NSCLC). Recent studies have shown that pati | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | $1,494,349 | Grant | Trans-NIH Recovery Act Research Support: Sarcoma is a heterogeneous disease with at least 50 different subtypes. This genetic diversity makes the development of new targeted therapies particularly challenging. However, one consistent theme now emerging is that activation of the IGF-1R/PI3K/Akt a | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| UNIVERSITY OF UTAH, THE | $624,403 | Grant | Trans-NIH Recovery Act Research Support: The goal of this proposal is to investigate the feasibility of treating ovarian epithelial carcinoma (OEC) with intelligent virus-mimetic nanogels (VM-nanogels). The VM nanogel has a core-shell type micelle-like structure. The core is constructed with pH- | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| MONTEFIORE MEDICAL CENTER | $667,124 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this project is to study how key biochemical pathways interact in controlling the normal characteristics and functioning of cells in tissue of the the large and small intestine, and the alterations in these pathways and their interactions t | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF MIAMI | $1,017,802 | Grant | Trans-NIH Recovery Act Research Support: Prostate cancer is the most common malignancy and the second highest cause of cancer mortality in American men. New prognostic and predictive biomarkers are urgently needed to better inform our treatment decisions. Recent studies have demonstrated that qu | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $644,216 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Experiments are proposed to investigate the interaction between two risk factors for drug abuse: prenatal stress and being female. It is hypothesized that prenatal stress alters the neural systems that respond to novel | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $1,451,567 | Grant | Trans-NIH Recovery Act Research Support: Child abuse and neglect are huge social problems affecting millions of infants, children, and adolescents in America. Several decades of research indicate that experiencing abuse or neglect is associated with substance abuse and a variety of other problem | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $926,942 | Grant | Trans-NIH Recovery Act Research Support: To pilot test a universal program developed to enhance family protective factors near the end of elementary school, thereby buffering children from the elevated risks of substance use and associated problems that will soon emerge in early adolescence. The | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $742,500 | Grant | Trans-NIH Recovery Act Research Support: This project is being supported with funds from the American Recovery and Reinvestment Act, which may involve a reduction in the research aims and scope. If necessary, a revised abstract will be posted soon and this notice removed. Consolidation of synap | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $790,319 | Grant | Trans-NIH Recovery Act Research Support: Regulatory RNAs are important mediators of gene expression in eukaryotic cells. BC RNAs, a neuronal subtype of regulatory RNAs, are translational repressors that have been implicated in the control of local protein synthesis at the synapse. On-site transl | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |