Listing all stimulus spending by amount, in descending order. Return to National Institutes of Health page
Amount refers to both the amount of stimulus funding going toward the project and the face value of the loan.
| Recipient | Amount | Type | Description | Federal Dept./Agency | Date |
|---|---|---|---|---|---|
| POLY-MED, INC. | $100,000 | Grant | Trans-NIH Recovery Act Research Support: Since early development of polymethyl methacrylate bone cement (PMMA-BC), there have been many efforts to develop alternative compositions to circumvent some of its clinical shortcomings, which include (1) monomer cytotoxicity; (3) inability to form stro | Health and Human Services, Department of / National Institutes of Health | 8/06/2009 |
| ARRAYOMICS INC | $99,999 | Grant | Trans-NIH Recovery Act Research Support: High Multiplexing Liquid Array Assay Platform The aim of this project is to expand the capabilities of a novel liquid array platform, based on Encoded Sortable Particle (ESP) technology to make it cost and performance compatible with high multiplex assays | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| ADVANCED LIQUID LOGIC INC. | $189,378 | Contract | : This is a phase I SBIR proposal that aims to demonstrate a near-patient platform for screening neonates with very high levels of bilirubin (hyperbilirubinemia). The proposed devise would be greatly useful in rapid identification and enable early treatment | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $412,291 | Grant | Trans-NIH Recovery Act Research Support: This research project investigates the mechanisms used by the opportunistic fungal pathogen, Candida albicans to produce disease. The long term goal of this research is to understand how C. albicans cells cause infection. Environmental sensing is likely t | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $406,250 | Grant | Trans-NIH Recovery Act Research Support: Hepatitis C virus (HCV) infection persists for years in most patients and leads to chronic liver disease despite robust immune responses. Although there are no clearly established in vitro correlates of protective immunity, multiple lines of evidence sugg | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $382,396 | Grant | Trans-NIH Recovery Act Research Support: Multiple Sclerosis is an autoimmune disease resulting from complex interactions between genetic background of the individual and his/her environment. Our combined data suggests that genetic deficiency in a pathway that controls the addition of specific su | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| COLORADO STATE UNIVERSITY | $577,038 | Grant | Trans-NIH Recovery Act Research Support: The pituitary transcription factor, Pit-1, is responsible for both normal development of the anterior pituitary gland and cell specific expression of three of the pituitary peptide hormones. A clear understanding of the regulation of transcription and cel | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| TUFTS MEDICAL CENTER PARENT, INC. | $198,750 | Grant | Trans-NIH Recovery Act Research Support: ClipR-59 is a member of Clip-170 protein family, characterized by presence of three ankyrin repeats and two cytoskeleton-associated protein-Glycine rich (CAP-Gly) domains (also referred as microtubule binding domain (MTB). However unlike other members of | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| THE CHILDRENS HOSPITAL LOS ANGELES | $995,180 | Grant | Trans-NIH Recovery Act Research Support: Sickle cell disease (SCD) is a genetic disease that causes severe, lifelong pain, debilitating organ toxicity and early death. Many of the complications can be ameliorated by blood transfusions, which in turn cause significant iron overload. A large numb | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $995,128 | Grant | Trans-NIH Recovery Act Research Support: This application is submitted in response to the NIH Announcement (RFA-OD-09-003) and the proposal addresses the broad Challenge Area (08): Genomics, and the specific Challenge Topic, 08-AA-104: Regional Central Nervous System (CNS) Gene Expression. Alco | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF IOWA, THE | $996,755 | Grant | Trans-NIH Recovery Act Research Support: Although some degree of gradual cognitive decline is nearly universal and a normal part of the aging process, previous research by our group has shown that age-related cognitive decline is amenable to intervention. Building on speed of processing theory, | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| DUKE UNIVERSITY | $819,998 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (08) Genomics and specific Challenge Topic, 08- AG-101: Genetic factors affecting rates of change in disease risk factors with age. Alzheimer's disease (AD) is the most critical unmet need in neurological me | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: The investigators will leverage their significant experience with CMS claims and their active participation in three nationwide research networks to compile a very large permanent (yet continually updatable) national data resource for the purposes of comp | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF WASHINGTON | $505,482 | Grant | Trans-NIH Recovery Act Research Support: We propose a response to Challenge 06-AG-104 that incorporates development of three novel tools and technologies that can alter or interrogate human mitochondrial function in vivo. We will then apply these tools to the study of aging heart and muscle in | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $745,716 | Grant | Trans-NIH Recovery Act Research Support: Amyloid is the dangerous brain plaque and tau protein tangles with in the brain cells tend to prevent neurons from communicating each other leading to loss of memory. Positron emission tomography (PET scan) can create image of the harmful beta amyoid plaq | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| CORNELL UNIVERSITY, INC | $756,523 | Grant | Trans-NIH Recovery Act Research Support: The proposed research takes advantage of the strengths of one of the oldest and most widely used neurological assessments in clinical practice, the Rey Auditory Verbal Learning Test (RAVLT). We will apply cutting-edge mathematical modeling tools that wer | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $802,594 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (03) Biomarker Discovery and Validation and specific Challenge Topic, 03-AI-101: Identification, characterization and evaluation of novel pathogen or host targets that may lead to the development of antimicr | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| DUKE UNIVERSITY | $977,459 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (04) Clinical Research and specific Challenge Topic 04-AI- 102: The human immune response to infection and immunization - Profiling via modern immunological methods and systems biology. The ability to monito | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $999,659 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (04) Clinical Research and specific Challenge Topic, 04-AR-101: Autoimmunity For Diseases Of The Skin, Joints, Muscle And Other Tissues-Develop reagents and analytic methods to identify, characterize, track, | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF PITTSBURGH THE | $857,596 | Grant | Trans-NIH Recovery Act Research Support: This research project seeks to improve understanding of the connection of bone marrow fat (BMF) with bone density, geometry and turnover by recruiting 150 men who are currently participating in the Osteoporotic Fractures in Men (MrOS) study at the Pittsbu | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: This proposal will provide information essential to informing treatment decisions for patients with psoriasis and future, longitudinal comparative effectiveness studies. Ultimately, this line of research will lead to more rationale treatment decisions and | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $955,275 | Grant | Trans-NIH Recovery Act Research Support: Our goal is to determine the effect of diet on skeletal acquisition, specifically whether perinatal diet initiates developmental programming of the skeleton that alters postnatal acquisition of bone mass, microarchitecture and strength. We have two aims: | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK INC | $915,108 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (15) 'Translational Science' and specific Challenge Topic '15-AR-104 Bone and the Nervous System'. Bone adaptation requires osteocytes to detect mechanical signals in situ and integrate the signals in the os | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $999,319 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (06) Enabling Technologies and specific Challenge Topic 06-AT-101: In this project, we propose two project areas based on the use of Magnetic Resonance Imaging modalities at both the cerebral (brain) and sub | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF IOWA, THE | $781,686 | Grant | Trans-NIH Recovery Act Research Support: This application addresses Broad Challenge Area (5), Comparative Effectiveness Research, and specifically Comparative Effectiveness Research on Cancer Screening, 05-CA-102. Significance: With our health care system in financial crisis, and colorectal canc | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: The ability of malignant glioma cells to invade normal brain severely limits all current therapies for this devastating disease. Blocking this process could therefore convert gliomas from an invasive, whole brain disease to a local diseaseG??one that coul | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $998,305 | Grant | Trans-NIH Recovery Act Research Support: This Challenge Grant entitled Oncogenic Human Papillomavirus Network will enable technologies that provide new tools and insights for basic research to create new avenues of research into the specific mechanisms that can lead to a better understanding of | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $998,080 | Grant | Trans-NIH Recovery Act Research Support: This research proposes a non-invasive blood test for prostate cancer which avoids the pitfalls that have plagued the Prostate Specific Antigen test (high false negatives and positives), a consequence of comparing a patient's test results to an average val | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| CORNELL UNIVERSITY, INC | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: Tumor angiogenesis represents a critical event of cancer that involves the recruitment of bone marrow derived endothelial progenitor cells; however, the exact mechanisms and effects by which microenvironmental conditions regulate these processes are not w | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $999,728 | Grant | Trans-NIH Recovery Act Research Support: Specific targeting of oncogenic signaling pathways with kinase inhibitors has vastly improved clinical outcomes for patients with a variety of cancer diagnoses, most notably patients with chronic myeloid leukemia. To expand this targeted-therapy approach | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC. | $478,448 | Grant | Trans-NIH Recovery Act Research Support: This application for an NIH RC1 Challenge Grant in Health and Science Research addresses the following Challenge Areas: (04) Clinical Research and (15) Translation Science. The specific Challenge Topics it addresses are 04-DK-104, Improve the diagnosis, s | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| WAYNE STATE UNIVERSITY (INC) | $999,094 | Grant | Trans-NIH Recovery Act Research Support: Malignant tumors evade the immune attack by exploiting the natural regulatory mechanisms of immune tolerance. CD4+CD25+ Tregs that play a critical role in immune tolerance accumulate in the draining lymph nodes and tumor mass of patients with multiple typ | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $986,304 | Grant | Trans-NIH Recovery Act Research Support: Vincristine is active against a wide variety of malignancies and has been shown to substantially improve outcomes. Although vincristine is among the most commonly used anticancer agents, little is known about optimal therapeutic dosing and it is widely re | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| WASHINGTON UNIVERSITY, THE | $755,349 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of the proposed study is to identify neurophysiological and behavioral markers of sensitivity to smoking cessation treatment. Although smoking widely recognized as the major preventable cause of death and substantial proportion of smokers | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $949,922 | Grant | Trans-NIH Recovery Act Research Support: Among US adults, 12.8% report nicotine dependence, and nicotine dependence is highly associated with a variety of DSM-IV Axis I and II disorders. Pathological gambling (PG), a serious public health problem with detrimental effects on individuals and fami | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $977,129 | Grant | Trans-NIH Recovery Act Research Support: This research proposal, entitled A Novel Epigenetic Gene Silencing Technology, addresses the broad Challenge Area: (06) Enabling Technologies, and specific Challenge Topic, 01-OD-107: Functional Modulation of Epigenomic Modifications. The ability to modul | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $923,663 | Grant | Trans-NIH Recovery Act Research Support: Although small-scale studies have evaluated oral disease in the developmentally disabled, the oral health status, treatment needs and helpful interventions for adults with developmental disabilities (DD) are largely unknown. The inability of many adults w | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| OLD DOMINION UNIVERSITY RESEARCH FOUNDATION | $897,574 | Grant | Trans-NIH Recovery Act Research Support: The project seeks to tailor existing Screening, Brief Intervention, Referral and Treatment (SBIRT) protocols for alcohol abuse to be used in dental practice settings. SBIRT protocols have demonstrated effectiveness in reducing alcohol use and related pro | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $999,999 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (15) Translational Science and specific Challenge Topic, 15-DE-101 Molecular Profiling and Developing Mouse Models for Salivary Gland Tumor Research. The proposed work will expand an ongoing successful resea | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| NORTHWESTERN UNIVERSITY | $998,506 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (13) Smart Biomaterials - Theranostics and specific Challenge Topic, 13-DE-101* Novel Self-Healing Smart Dental and Bio-Restorative Materials. Effective repair and replacement of skeletal tissue by synthetic | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $971,456 | Grant | Trans-NIH Recovery Act Research Support: The Use of Erythropoietin to Reprogram Oral and Craniofacial Stem Cells. This project directly addresses Challenge Area (14)-Stem Cells, specifically 14-DE-101* Reprogramming of Cells from Oral and Craniofacial Tissues in which we developed a novel approa | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF PITTSBURGH THE | $999,180 | Grant | Trans-NIH Recovery Act Research Support: This study explores the redox reactions of nitrite and how fatty acid nitro derivatives might transduce salutary actions of dietary and endogenously-produced nitrite. In particular, preliminary studies have shown that nitro-fatty acids lower blood glucose | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF PITTSBURGH THE | $970,117 | Grant | Trans-NIH Recovery Act Research Support: The liver performs over 3,000 functions critical to maintaining the organism, ranging from production and secretion of proteins such as albumin, clotting factors and antiproteases, to metabolism and excretion of exogenous compounds such as drugs or toxins | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| WASHINGTON UNIVERSITY, THE | $999,035 | Grant | Trans-NIH Recovery Act Research Support: This application addresses Broad Challenge Area (04) Clinical Research and specific Challenge Topic, 04-DK-106: Preservation/Recovery of endogenous insulin secretion. Diabetes is a serious and common metabolic disorder that afflicts 18 million Americans w | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $997,523 | Grant | Trans-NIH Recovery Act Research Support: The hypothalamic-pituitary-adrenal (HPA) axis and its byproduct, cortisol, have been hypothesized to be the mediators that links chronic stress to adverse health outcomes, including increased obesity risk. This mediation is hypothesized to occur via sever | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $999,229 | Grant | Trans-NIH Recovery Act Research Support: This grant application is a response to Topic 15-OD (ORDR)-101. Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is an inherited cardiac disease characterized by severe ventricular arrhythmias, as well as progressive replacement of healthy myocardiu | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UMDNJ-ROBERT WOOD JOHNSON MEDICAL SCHOOL | $2,605,144 | Grant | Trans-NIH Recovery Act Research Support: Red blood cell transfusions are extremely common medical interventions with more than 11 million red blood cell units transfused in the United States and 75 million worldwide. Yet, it remains unclear when patients should receive red blood cell transfusion | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $3,072,964 | Grant | Trans-NIH Recovery Act Research Support: The potential for widespread dissemination of lethal poxviruses such as smallpox during bioterrorism has led to renewed scientific efforts to understand the pathogenesis of this virus and related orthopoxviruses. Poxviruses have evolved many strategies t | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $886,850 | Grant | Trans-NIH Recovery Act Research Support: Androgen receptor regulation of reproductive function -- ARRA MAGE-11 (melanoma antigen-A11) was identified as a novel androgen receptor (AR) coregulator that increases AR transcriptional activity. MAGE-11 is a member of the MAGE gene family that evolved | Health and Human Services, Department of / National Institutes of Health | 9/02/2009 |
| UNIVERSITY OF IOWA, THE | $924,818 | Grant | Trans-NIH Recovery Act Research Support: The molecular mechanisms underlying uterine smooth muscle excitation during pregnancy are unknown, and this deficit has hampered the development of effective therapies for uterine dysfunction. The maintenance of uterine quiescence during pregnancy require | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| GEORGIA HEALTH SCIENCES UNIVERSITY RESEARCH INSTITUTE, INC. | $731,214 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this project is to elucidate the functional roles of glycosphingolipids (GSLs), particularly gangliosides, during normal nervous system development and under pathological conditions. These molecules are abundant in the nervous system | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| SEATTLE BIOMEDICAL RESEARCH INSTITUTE | $964,000 | Grant | Trans-NIH Recovery Act Research Support: Despite more than 20 years of molecular investigation, little is currently known about the essential process of the transcription of protein-coding genes in Leishmania and other trypanosomatids, other than that it differs from that in other eukaryotes bec | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $981,556 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Varicella zoster virus (VZV) causes varicella during primary infection, persists in sensory ganglia and may reactivate from latency to cause zoster. VZV pathogenesis depends upon its tropisms for T cells, skin and sens | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $949,500 | Grant | Trans-NIH Recovery Act Research Support: The arenaviruses cause devastating viral hemorrhagic fever (VHF) diseases of humans with high fatality rates. Because there is negligible or at best limited antiviral treatment available for these diseases, especially the Old World Lassa fever virus (LFV) | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $678,252 | Grant | Trans-NIH Recovery Act Research Support: Our studies are directed at understanding how the immune system distinguishes between the antigens present in our own bodies and those of disease producing organisms such as viruses and bacteria. Studies from other laboratories have shown that the type a | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) | $584,781 | Grant | Trans-NIH Recovery Act Research Support: This award is a bridge grant that has allowed us to continue experiments that support an RO1 application. The RO1G??s overall purpose is to study how Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis, acquires iron, an essential | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| DUKE UNIVERSITY | $704,541 | Grant | Trans-NIH Recovery Act Research Support: This application, to be supported for 1 year with bridge funds from ARRA, explores the long term outcomes of thymus transplantation. Over the last 15 years, our laboratory has established that thymus transplantation is a successful therapeutic strategy f | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| UNIVERSITY OF OKLAHOMA | $461,818 | Grant | Trans-NIH Recovery Act Research Support: It is generally accepted that for an individual species to co-exist indefinitely with the thousands of species that make up the intestinal microbiota it must use one or a few limiting carbon sources better than all other species (nutrient-niche hypothesis | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF MARYLAND | $300,000 | Grant | Trans-NIH Recovery Act Research Support: The rapid rise in antibiotic resistance in the past two decades increases the need for alternative therapeutic strategies. A current approach to developing new antibiotics is to target non-essential functions that reduce virulence of infecting organisms b | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| GEORGIA HEALTH SCIENCES UNIVERSITY RESEARCH INSTITUTE, INC. | $330,750 | Grant | Trans-NIH Recovery Act Research Support: Novel therapeutic strategies such as modulation of dendritic cell and T cell functions have shown great potential in clinical transplantation. HLA-G is a molecule that plays a significant role in establishing complex mechanisms to protect semi-allogeneic | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| YALE UNIVERSITY | $935,049 | Grant | Trans-NIH Recovery Act Research Support: Aberrant somitogenesis leads to birth defects in humans. Later in life abnormal Notch, Wnt or Fgf signaling causes malignancies such as colon cancer and leukemia. We use zebrafish as a tractable, relatively inexpensive vertebrate model system to study how | Health and Human Services, Department of / National Institutes of Health | 8/07/2009 |
| TUFTS MEDICAL CENTER | $322,000 | Grant | Trans-NIH Recovery Act Research Support: We propose here a series of studies that will greatly advance the understanding of the regulation of a particular ion channel protein, the large-conductance calcium-activated potassium channel, or BK channel, which plays a vital role in the regulation of | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $487,747 | Grant | Trans-NIH Recovery Act Research Support: One of the greatest challenges in biochemistry is to study dozens to hundreds of molecules simultaneously using single cells or in single cell types obtained from complex, living tissue. Here, we propose a new technology, termed ?microlysis technology?, w | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $647,074 | Grant | Trans-NIH Recovery Act Research Support: This challenge grant will help to stimulate the economy as it proposes to hire two new full-time research assistants. These individuals will work on a project aimed at assesing the social, behavioral, and ethical implications of direct availability of per | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $998,371 | Grant | Trans-NIH Recovery Act Research Support: The main objective of this project is to develop a protein based therapy to enhance the endothelial barrier properties. Although acute lung injury (ALI) is a major cause of morbidity and mortality, no curative therapies are available. The main pathology i | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| DUKE UNIVERSITY | $990,260 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (15) Translational Science and specific Challenge Topic, 15- HL-101: Develop improved biocompatible surfaces for implantable blood-contacting medical devices. More than five million Americans, and increasing | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| DUKE UNIVERSITY | $534,001 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (15) Translational Science, and the specific Challenge Topic, 15-NS-106: Identifying mechanisms that underlie nervous system development and function. This Challenge solicits mechanistic studies that elucida | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| LUDWIG INSTITUTE FOR CANCER RESEARCH LTD | $998,118 | Grant | Trans-NIH Recovery Act Research Support: This application addresses two Broad Challenge areas (15) Translational Science, including specific Challenge Topics 15-NS-104 (Early-stage therapy development) and 15-NS-103 (Demonstration of 'proof-of-concept') and Broad Challenge area (08) Genomics, sp | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF UTAH, THE | $995,906 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This application addresses broad Challenge Area: (06) Enabling Technologies and specific Challenge Topic: 06-MH-103 New technologies for neuroscience research. Develop technologies for neuroscience research that are so | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $988,928 | Grant | Trans-NIH Recovery Act Research Support: DEVELOPING A NORTH AMERICAN MITOCHONDRIAL DISEASE CONSORTIUM This application addresses one broad Challenge Area, (07) Enhancing Clinical Trials (07-OD(ORDR)-102: Rare Disease Genetic Patient Registry. By most epidemiological studies, primary mitochondria | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $410,298 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (12) Science, Technology, Engineering and Mathematics Education (STEM) and specific Challenge Topic 12-OD-104: Innovative Approaches to STEM Education. One of the cent | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $813,566 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area of 'Information Technology for Processing Health Care Data' (Area # 10) and two specific Challenge topics (10-RR-101): Information Technology Demonstration Projects Facilitating Secondary Use of Healthcare D | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| OHIO STATE UNIVERSITY, THE | $972,451 | Grant | Trans-NIH Recovery Act Research Support: Science Learning and Scientific Reasoning This application addresses broad Challenge Area (12) Science, Technology, Engineering and Mathematics Education (STEM) and specific Challenge Topic, 12-OD-101: Efficacy of educational approaches toward promoting S | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| KAISER FOUNDATION HOSPITALS | $24,846,000 | Grant | Trans-NIH Recovery Act Research Support: The goal of this 'Grand Opportunities' project is to create a unique and comprehensive population-based resource for research into the genetic and environmental basis of common age-related diseases and their treatment, and factors influencing healthy agin | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| NEW YORK UNIVERSITY (INC) | $3,994,224 | Grant | Trans-NIH Recovery Act Research Support: Staff & infrastructure in place. 107 patients donated blood, oral & fecal specimens; 2,977 aliquots stored (127 Oral DNA, 183 Fecal DNA); 166 oral & 198 fecal aliquots at MSKCC for analysis; proof-of-concept study has begun; pharmacy dispensing antibioti | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $1,453,349 | Grant | Trans-NIH Recovery Act Research Support: Parkinson?s Disease (PD) as well as other neurodegenerative diseases are associated with oxidative damage. In PD, there is an early reduction in reduced glutathione in the substantia nigra, as well as increases in markers of lipid, protein and DNA oxidati | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $4,750,000 | Grant | Trans-NIH Recovery Act Research Support: In this application, we articulate the vision for a center that will integrate recent computational and experimental advances in cancer systems biology toward the genome-wide prioritization of therapeutic targets using high-throughput screening approaches | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| WILLIAM MARSH RICE UNIVERSITY | $1,955,950 | Grant | Trans-NIH Recovery Act Research Support: Oral cancer, largely oral squamous cell carcinoma (OSCC), is a global health problem afflicting close to 300,000 people each year. Despite significant advances in surgical procedures and treatment, the long-term prognosis for patients with OSCC remains po | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| GENERAL ELECTRIC COMPANY | $1,238,601 | Grant | Trans-NIH Recovery Act Research Support: By coupling a disruptive technology, Digital Micro-Printing (DMP) with advances in miniature, low-cost electronics, the project team will improve access to Point-of-Care ultrasound for Maternal Health thereby reducing healthcare disparities, and enabling | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $1,198,981 | Grant | Trans-NIH Recovery Act Research Support: The objective of this project is to develop reliable and reproducible exposure assessment methodologies and protein expression-based methods aimed at the development of biological/ toxicological response endpoints that can serve potential biomarkers for w | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| WASHINGTON STATE UNIVERSITY | $2,750,000 | Grant | Trans-NIH Recovery Act Research Support: Plants are the source of many important medicinal compounds and the diversity of plant species and biochemistry suggests that many more are potentially available. The current understanding of the formation of plant-derived medicinal compounds at the enzym | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $914,235 | Grant | Trans-NIH Recovery Act Research Support: Treatment for schizophrenia involves both behavioral and rehabilitation interventions and pharmacotherapy. A number of studies have documented the effectiveness of various interventions and treatments for schizophrenia, but these studies fail to consider | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $881,731 | Grant | Trans-NIH Recovery Act Research Support: Promote regeneration and repair in the digestive system, liver, pancreas, kidneys, Hematologic, and urological system. The stress of major surgical procedures, irradiation, chemotherapy, nutritional deprivation, and systemic inflammation all lead to atrop | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $605,088 | Grant | Trans-NIH Recovery Act Research Support: Extracorporeal Support for Emergent (Uncontrolled) Donation Following Cardiac Death Introduction: The limited availability of donor organs for transplantation has led to an increased interest in the use of donation following cardiac death (DCD) donors. Ho | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| IMMUNE DISEASE INSTITUTE, INC. | $995,573 | Grant | Trans-NIH Recovery Act Research Support: Dysregulation of the immune system, which induces an aberrant activation of leukocytes, plays a critical role in the pathogenesis of a wide range of autoimmune and immunological disorders including such inflammatory bowel diseases (IBD) as ulcerativecolit | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $973,419 | Grant | Trans-NIH Recovery Act Research Support: In the last several years, there has been a remarkable transformation in the field of cancer therapeutics, with a shift from traditional 'cytotoxic' agents to targeted therapies. There has also been a rapid increase in the number of potential compounds av | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF WASHINGTON | $990,434 | Grant | Trans-NIH Recovery Act Research Support: Multiplexed diagnostic assays that are rapid, easy to use, and very low cost are needed for use at the point of care (POC), especially in low-resource settings. Microfluidic systems can bring laboratory-quality multiplexed assays to POC applications, but | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: This study examines 1800 patients treated at more than 20 centers with expertise in robotic and standard prostate surgery; the patients have been evaluated for quality of life before and after surgery, and for complications, costs, and cancer control. WeG | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF IOWA, THE | $581,057 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (15) Translational Science and specific Challenge Topic, 15- ES-101*: Effects of Environmental Exposures on Phenotypic Outcomes Using Non-Human Models. Farmers as a group have the highest occupational risk f | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $837,538 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (15): Translational Science and specific Challenge Topic, 15- ES-101*: Effects of Environmental Exposures on Phenotypic Outcomes Using Non-human Models. The overall goal of this research proposal is to study | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $811,503 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (08) Genomics and specific Challenge Topic 08-ES-104, Identification of Alterations in Epigenetic Marks Related to Environmental Exposures. Environmental exposure to foreign chemicals with estrogenic activit | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| WAYNE STATE UNIVERSITY (INC) | $1,044,749 | Grant | Trans-NIH Recovery Act Research Support: Aims of the proposal: 1) Contribute to the development and competency of pre-service STEM teachers through integration of Environmental Health-based Biotechnology lessons into an existing methods course. 2) Intergrate Environmental health science researc | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $998,678 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (03) Biomarker Discovery and Validation and specific challenge topic, 03-ES-101 Validation of new exposure assessment methodologies Suboptimal dietary macronutrient choices are arguably the major environment | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF MIAMI | $764,972 | Grant | Trans-NIH Recovery Act Research Support: This application addresses the NIH broad Challenge Area (11) Smart Biomaterials, and the specific Challenge Topic, 11-EB-103, Modular Platforms for Regeneration and Development. Working under this award we will create for the first time a th | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $790,120 | Grant | Trans-NIH Recovery Act Research Support: This proposal outlines a set of experiments under broad challenge area (05) Comparative Effectiveness Research which will address the highest-priority challenge 05-EY-102 Treatment of Pediatric Eye Diseases and Disorders. Specifically, it will compare res | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $992,398 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (15) Translational Science and specific Challenge Topic, 15-EY-101: Protein misfolding in degenerative diseases of the eye. Identifying therapeutic pharmacological agents/drugs that prevent the misfolding/ag | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $911,875 | Grant | Trans-NIH Recovery Act Research Support: Challenge Area: 06 Enabling Technologies. Specific Challenge Topic: 06-GM-101 Structural Analysis of Macromolecular Complexes. A major challenge in chromatin biology and molecular cytology is how to study the macromolecular structures of specific epigenet | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| EMORY UNIVERSITY | $775,000 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (14) Stem Cells and specific Challenge Topic, 14-AG-105 Exploratory studies of induced pluripotent stem (iPS) cells from healthy individuals and patients with mental/nervous system disorders. Chromatin insul | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $746,062 | Grant | Trans-NIH Recovery Act Research Support: This application addresses the broad Challenge Area: 08: Genomics, and the specific Challenge Grant Topic: 08-AG-105**: Approaches to study the interactions among individual behaviors, social and physical environments, and genetic/epigenetic processes dur | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF CHICAGO, THE | $500,000 | Grant | Trans-NIH Recovery Act Research Support: This grant proposes to significantly advance the current technology for generation of mouse models of human genetic disease. This addresses broad Challenge Area (15) Translational Science, and Specific Challenge Topic 15-OD(ORDR)-101: Pilot projects for p | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF MARYLAND | $971,364 | Grant | Trans-NIH Recovery Act Research Support: The purpose of the proposed studies is to evaluate a novel combination treatment in experimental traumatic brain injury (TBI). Traditional treatment strategies for TBI aim to prevent delayed neuronal cell death by inhibiting one proposed cell death mechan | Health and Human Services, Department of / National Institutes of Health | 11/19/2009 |
| CALIFORNIA INSTITUTE OF TECHNOLOGY | $944,236 | Grant | Trans-NIH Recovery Act Research Support: A two year project is proposed to expand, to exploit, to extend, and to apply on a demonstration basis a completely novel approach to high throughput cis-regulatory analysis. We have very recently developed the initial component of this new technology as | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $914,044 | Grant | Trans-NIH Recovery Act Research Support: This project brings together top experts on nanomedicine, biomedical engineering, law, policy, and bioethics to produce the first systematic and comprehensive recommendations on how to protect human participants in research on nanodiagnostics and nanother | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| WISTAR INSTITUTE OF ANATOMY & BIOLOGY | $990,161 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Areas (15): Translational Science and Specific Challenge Topic 15-HL-102: Develop therapeutic strategies for heart, lung, and blood diseases based on microRNA technology. One type of RNA editing involves the conv | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $992,302 | Grant | Trans-NIH Recovery Act Research Support: We request funding to support one additional cycle of observational follow-up of Women's Health Study (WHS) participants, to ascertain and validate cardiovascular disease (CVD) and cancer endpoints among cohort subjects, in order to retain jobs, support t | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK | $764,666 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (05): Comparative Effectiveness Research; Challenge Topic 05-HL-104 Reducing cardiovascular risk in moderate-risk and asymptomatic patients. More than half of the 500,000 coronary artery deaths each year in | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area 15: Translational Science and specific Challenge Topic 15-RR-101: Applied Translational Technology Development. It is evident that prior to dialysis access failure (thrombosis), access flow decreases for eve | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $999,514 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (10) Information Technology for Processing Health Care Data and specific Challenge Topic 10-LM-101: Informatics for post-marketing surveillance. The overall goal of this study is to develop a generalizable f | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| EMORY UNIVERSITY | $967,019 | Grant | Trans-NIH Recovery Act Research Support: Preventing Depression in People with Epilepsy: An Extension of Project UPLIFT Funded by the Centers for Disease Control and Prevention (CDC) as a home-based treatment for depression in people with epilepsy, Project UPLIFT was developed to provide group d | Health and Human Services, Department of / National Institutes of Health | 9/20/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $698,726 | Grant | Trans-NIH Recovery Act Research Support: This application addresses Challenge Area 15 (Translational Science). Specific Challenge Topic 15-MH-109 Prefrontal cortex regulation of higher brain functions and complex behavior. There is growing emphasis on understanding what might produce resilience | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $963,964 | Grant | Trans-NIH Recovery Act Research Support: NIH Broad Challenge Area 15 - Translational Science NIMH Specific Challenge Topic 15-MH-109 - Prefrontal cortex regulation of higher brain function and complex behaviors. Abstraction is the ability to detect and store the commonalities across experiences | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF WASHINGTON | $811,718 | Grant | Trans-NIH Recovery Act Research Support: As the numbers of older adults with cognitive problems requiring care in this country increase, so does the need for well trained staff. Assisted living residences are currently estimated to provide care for over two million older adults, with over half | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $693,115 | Grant | Trans-NIH Recovery Act Research Support: The objective of this grant is to implement a high throughput screen for small molecules that potentiate the activity of FosB, a transcription factor that promotes resilience and antidepressant-like responses in several animal models and is deficient in t | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION | $951,629 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to validate phosphodiesterase-2 (PDE2) as a pharmacological target for the treatment of mood disorders and to discover novel, selective inhibitors. Inhibition of PDE2 enhances cGMP signaling by blocking it hydrolysis and produ | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $991,790 | Grant | Trans-NIH Recovery Act Research Support: Children with Autism Spectrum Disorders (ASD) are impaired in their ability to produce and perceive dynamic facial expressions (Adolphs, Sears, and Piven, 2001). Advanced computer vision technologies can now be leveraged in the investigation of issues suc | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| DUKE UNIVERSITY | $996,472 | Grant | Trans-NIH Recovery Act Research Support: This application addresses Broad Challenge Area (03) Biomarker, Discovery and Validation, with specific Challenge Topic, 03-MH-101, Biomarkers in Mental Disorders. We propose to leverage an ongoing collaboration among faculty from several disciplines to i | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $999,824 | Grant | Trans-NIH Recovery Act Research Support: Challenge Area: 14 --Stem Cells Challenge Topic: 14-MH-101*, 'Developing iPS cells for mental disorders' The recent description of somatic cell reprogramming to an embryonic stem (ES) cell-like phenotype, termed induced pluripotent stem (iPS) cell technol | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $932,912 | Grant | Trans-NIH Recovery Act Research Support: Defining of Neurodevelopmental Pathways Regulated by Neuregulin- DISC1 Interactions Determining if neuregulin 1 (NRG1) signaling modulated DISC1 expression in the developing brain is a goal of this project. Towards this goal, we found that NRG signaling | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| MCLEAN HOSPITAL CORPORATION, THE | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area 03: Biomarker Discovery and Validation, and the specific Challenge Topic 03-MH-101: Biomarkers in Mental Disorders. Attention-deficit/hyperactivity disorder (ADHD) is the most prevalent behavioral disorder o | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF KENTUCKY | $999,995 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (04) Clinical Research and specific Challenge Topic, 04-MH-101, Autism: Addressing the challenge. Although the focus on early identification efforts in recent years has been effective in sharply increasing t | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC. | $3,963,447 | Grant | Trans-NIH Recovery Act Research Support: The CER grant proposal 'Developing Information Infrastructure Focused on Cancer Comparative Effectiveness Research' will aid public health in several ways. First, the development of CER infrastructure will give biomedical researchers a resource that will | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF NEBRASKA | $990,796 | Grant | Trans-NIH Recovery Act Research Support: KaposiG??s sarcoma (KS) is a devastating malignancy prevalent among immunosuppressed individuals, including AIDS patients and patients who have undergone organ transplants. The global seroprevalence of KSHV is uneven. It is endemic in sub-Saharan Africa w | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| GLOBAL VIRAL FORECASTING, INC. | $1,813,010 | Grant | Trans-NIH Recovery Act Research Support: This proposal seeks to apply an innovative, streamlined approach to facilitate the discovery of previously unidentified viral signatures in the several major human cancers from skin, kidney, brain, colon,and the pancreas. This pilot effort will form the b | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: Kaposi's sarcoma-associated herpesvirus (KSHV) has been consistently identified in Kaposi's sarcoma (KS) tumors, primary effusion lymphoma (PEL), and Multicentric Castleman's disease. Although classical KS has a low prevalence rate worldwide, the more agg | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| EMORY UNIVERSITY | $999,190 | Grant | Trans-NIH Recovery Act Research Support: WHO estimates that there are currently more than 30 million people living with HIV/AIDS and there is a great need to develop a safe and effective therapy that requires short-term intervention and long-term control of viral replication. The overall goal of | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $1,090,736 | Grant | Trans-NIH Recovery Act Research Support: We hypothesize that addictive drugs alter cellular lipid pathways in brain and peripheral tissues, and that such alterations influence the transition to compulsive drug use. A corollary of this idea is that peripheral lipid alterations might be used as bi | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| NATIONAL DEVELOPMENT AND RESEARCH INSTITUTES, INC. | $3,439,782 | Grant | Trans-NIH Recovery Act Research Support: The majority of individuals in criminal justice settings across the U.S. have a critical need for sciencebased, psychosocial treatment that targets substance use and HIV risk behavior. The investigative team has developed and demonstrated the efficacy of | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| DUKE UNIVERSITY | $4,507,931 | Grant | Trans-NIH Recovery Act Research Support: .Abstract G?Metabolomics Network for Drug Response PhenotypeG? Response to Recovery Act Limited Competition for NIH Grants: Research and Research Infrastructure G?Grand OpportunitiesG? (RC2), RFAOD- 09-004-Linking Metabolomics to Pharmacogenomics Cardiova | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $1,331,711 | Grant | Trans-NIH Recovery Act Research Support: This project seeks to generate new large-scale nationally representative public-use data for the United States that are crucial for conducting scientific and policy-relevant research on (1) immigrant health and mortality and (2) how immigration contribute | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF CALIFORNIA, SANTA CRUZ | $1,095,651 | Grant | Trans-NIH Recovery Act Research Support: The potential use of nanopores for DNA sequencing has gained significant momentum. This is partly due to innovative solid state techniques, but more so due to breakthroughs using biological pores. One promise of nanopore sequencing has been very long read | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF WASHINGTON | $3,920,116 | Grant | Trans-NIH Recovery Act Research Support: This application addresses NHGRI RFA-OD-09-004 for Medical Sequencing Discovery Projects. The ultimate goal of this proposal is to scale a new approach to identify the candidate genes and mutations that underlie rare Mendelian diseases in humans by exome | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| THOMAS JEFFERSON UNIVERSITY | $1,953,226 | Grant | Trans-NIH Recovery Act Research Support: We have developed a safe and effective transplant approach for both matched sibling and haploidentical related transplants which addresses the problem of donor availability in patients with leukemia, lymphoma, and related disorders. This approach has been | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $2,228,805 | Grant | Trans-NIH Recovery Act Research Support: The goal of the proposed work is the development of novel approaches to the stimulation of fetal hemoglobin (HbF) production in red blood cells of adults. HbF is a known modifier of the severity of the major hemoglobin disorders, sickle cell anemia and be | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| CHILDRENS HOSPITAL OF PHILADELPHIA | $1,962,019 | Grant | Trans-NIH Recovery Act Research Support: This project addresses the NHLBI RC2 GO application entitled 'Characterizing Differentiated Heart, Lung, and Blood Cells Derived by Reprogramming Human Embryonic and Induced Pluripotent Stem Cells.' Emerging technologies to generate induced pluripotent st | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $494,850 | Grant | Trans-NIH Recovery Act Research Support: Built in 1978, strategically located at the center of the Health Sciences Region on the campus of the University of California, San Diego, the Medical Teaching Facility vivarium includes 26 mouse housing rooms capable of holding 69 racks and over 11,000 b | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $991,039 | Grant | Trans-NIH Recovery Act Research Support: This proposal describes the development of a gene regulation system in the context of AAV gene therapy for age related macular degeneration (AMD). AMD is a growing disease and a major cause of visual disability in the aging population with a significant s | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $955,239 | Grant | Trans-NIH Recovery Act Research Support: A novel hybrid ion mobility/linear ion trap mass spectrometer having unique capability for characterizing the structures of complex biomolecules will be constructed. It will then be applied to the analysis of prototype glycan isomers and glycans derived f | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| ROCKEFELLER UNIVERSITY FACULTY AND STUDENTS CLUB INC, THE | $943,256 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area 06: Enabling Technologies and specific Challenge Topic 06-GM-101: Structural Analysis of Macromolecular Complexes. It focuses on the multiprotein Mediator complex, which has been implicated as a critical coa | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| COLORADO STATE UNIVERSITY | $674,966 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (06) Enabling Technologies, and specific Challenge Topic 06-CA-102: Transient Molecular Complexes in Cancer. Virtually all cellular processes, including those involved in cell growth, differentiation, and ap | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| OREGON STATE UNIVERSITY | $963,192 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (06) Enabling Technologies and specific Challenge Topic, 06-GM-101: Structural analysis of macromolecular complexes. We plan to develop a new method for atomic structure determination of proteins from electr | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| J CRAIG VENTER INSTITUTE INC | $997,969 | Grant | Trans-NIH Recovery Act Research Support: JCVI will develop a method to measure gene expression in individual cancer cells obtained from human blood. These circulating cancer cells (CTCs) are very rare but can be responsible for the spread of cancer throughout the body by metastasis. With new s | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $991,685 | Grant | Trans-NIH Recovery Act Research Support: This application addresses the Challenge Area (03) Biomarker Discovery and Validation. The specific topic covered in this application is the high priority topic entitled: 03-HL-101 Identify and validate clinically relevant, quantifiable biomarkers of diag | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | $790,008 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant: Chronic inflammation is a major contributor to the onset and progression of atherosclerosis and other vascular disorders. Studies of inflammation have focused primarily on the initiating processes and less attention has | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC. | $622,810 | Grant | Trans-NIH Recovery Act Research Support: Considerable advances have been made in the study of opioid receptor structure and function, and in recent years evidence has accumulated that opioid receptors can interact with one another. Early studies demonstrated that antagonism of delta opioid recep | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $353,442 | Grant | Trans-NIH Recovery Act Research Support: The primary goal of the research proposed in this competitive renewal application is to understand the role of Akt downstream signaling pathways in epithelial carcinogenesis. During the previous funding period, we discovered that Akt activation is an impo | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $648,384 | Grant | Trans-NIH Recovery Act Research Support: The long-range goal of this research is to understand the mechanism of glucocorticosteroid action in lymphoid malignancy, providing information to guide development of novel therapeutic approaches. Glucocorticoids including prednisone and dexamethasone ar | Health and Human Services, Department of / National Institutes of Health | 6/19/2009 |
| UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE | $1,498,205 | Grant | Trans-NIH Recovery Act Research Support: The long-term objectives of this proposal are to develop and refine methods of breast cancer staging in patients that are substantially less morbid than current methods, yet still provide the same diagnostic and therapeutic benefits. This project is a con | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $495,341 | Grant | Trans-NIH Recovery Act Research Support: We use state-of-the-art technology including computational biological simulations on the Blue Gene/L Super Computer, knockout mouse model and other molecular biological methods for the studies. These preclinical studies are designed to lead to the develop | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF CONNECTICUT | $671,376 | Grant | Trans-NIH Recovery Act Research Support: Signals mediated by tyrosine phosphorylation control a host of important biological activities, and when dysregulated can cause human diseases such as cancer and immune disorders. SH2/SH3 adaptors play a central role in tyrosine kinase signaling, but thei | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $563,612 | Grant | Trans-NIH Recovery Act Research Support: Redox Regulation of Rho-GTPases in the Vasculature - ARRA Rho-like GTPases are important players in vascular function due to their ability to regulate the actin cytoskeleton. They are involved in physiological processes such as smooth muscle cell contrac | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $656,560 | Grant | Trans-NIH Recovery Act Research Support: Kaposi's sarcoma, the most prevalent malignancy in AIDS patients, is characterized by proliferating spindle cells of endothelial cell (EC) origin, infiltration by inflammatory cells and the presence of the KS herpesvirus (KSHV) in lesions. The ultimate go | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF MIAMI | $598,442 | Grant | Trans-NIH Recovery Act Research Support: Tumors appear to be very sensitive to virus infection compared to normal cells. We aim to exploit these observations by developing novel, viral-based therapies that specifically kill tumor cells. Such strategies should lead to new anti-cancer therapies. | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON | $598,443 | Grant | Trans-NIH Recovery Act Research Support: In the past funding period we confirmed our major hypothesis that progastrin peptides (PG) exert proliferative/anti-apoptotic/co-carcinogenic effects on intestinal/colonic epithelial cell lines, in vitro and in vivo, and increase the risk of colon carcino | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $777,996 | Grant | Trans-NIH Recovery Act Research Support: This proposal focuses on research in the area of acyclic diastereoselective synthesis, with emphasis on the development of novel allylmetal reagents for application to the synthesis of several biologically active natural products, including nigricanoside | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $1,456,042 | Grant | Trans-NIH Recovery Act Research Support: In this application, we propose to create a multi-disciplinary Center for Skin Stem Cell Biology based within the Department of Dermatology at the College of Physicians & Surgeons at Columbia University. This center will build on the existing research exc | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $109,890 | Grant | Trans-NIH Recovery Act Research Support: In all vertebrate, the autonomous spinal networks that generate movements are referred to as central pattern generators (CPGs). The principal neurons in the locomotor CPG include ipsilateral rhythmogenic interneurons, (rhythm generators), commissural inte | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $31,400 | Grant | Trans-NIH Recovery Act Research Support: Abnormal development of the nervous system is thought to underlie many complex neurological disorders. In the past decade, research in several vertebrate organisms has shown the bHLH transcription factor Ascl1 (previously Mash1) is essential for neuronal | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $163,656 | Grant | Trans-NIH Recovery Act Research Support: Mechansisms of preferential reinveration Over 40,000 Americans suffer peripheral nerve injury each year. Of these, only 10% will regain normal function. Results of surgical treatment are compromised by the limited ability of peripheral nerve to support ax | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $359,313 | Grant | Trans-NIH Recovery Act Research Support: NOT-OD-09-058: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications Gamma-aminobutyric acid type A receptors (GABAARs) mediate synaptic inhibition in the brain and are modulated by a variety of clinically important dr | Health and Human Services, Department of / National Institutes of Health | 9/20/2009 |
| GEORGETOWN UNIVERSITY (THE) | $231,735 | Grant | Trans-NIH Recovery Act Research Support: Loss of white matter at the site of traumatic spinal cord injury (SCI) interrupts critical ascending and descending tracts and thus precludes normal function in the spinal cord distal to the site of injury. In the last project period we identified a previ | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $123,366 | Grant | Trans-NIH Recovery Act Research Support: The broad, long-term objectives of this project are to gain novel knowledge about a highly specialized calcium (Ca2+) channel - the inositol (1,4,5)-trisphosphate receptor (InsP3R). The proposed studies are fundamental to understanding Ca2+ signaling and | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF IOWA, THE | $298,575 | Grant | Trans-NIH Recovery Act Research Support: PREDICT-HD is an international 30-site observational study of persons at-risk for Huntington's disease (HD). PREDICT-HD capitalizes on two unique aspects of HD among neurodegenerative disorders the ability to know in advance who will develop the disease a | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $63,444 | Grant | Trans-NIH Recovery Act Research Support: The main goals of the project are to develop a method for blocking granule cell axon sprouting and synaptogenesis and then determine whether such blockade reduces epileptogenesis in a rodent model of temporal lobe epilepsy. This request is for funds to up | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| WAYNE STATE UNIVERSITY (INC) | $120,565 | Grant | Trans-NIH Recovery Act Research Support: Our experimental plan in our Stimulus award is to test the hypothesis that the R69C mutation in myelin protein zero (MPZ) causes a severe dysmyelinating inherited neuropathy in humans by disrupting the unfolded protein response; a process in which malfold | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF PUERTO RICO-MEDICAL SCIENCES CAMPUS | $600,000 | Grant | Trans-NIH Recovery Act Research Support: The scope of the 'Clinical Research Education and Career Development (CRECD) in Minority Institutions' (R25RR17589) is to enhance the participation of minority health professionals in clinical and translational research that will have a significant impact | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| MOREHOUSE SCHOOL OF MEDICINE, INC., THE | $536,416 | Grant | Trans-NIH Recovery Act Research Support: The Multidisciplinary Clinical and Translational Research (MCTR) Certificate Program at MSM addresses the needs of a wide variety of trainees that are part of multidisciplinary research teams and benefit from MCTR training that is not currently provided b | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| DIVERSITY FILMS INC | $254,883 | Grant | Trans-NIH Recovery Act Research Support: This award is a supplement to the parent grant#5R25RR018510-05, Serial Passage: AIDS, Race, and Culture Phase II. It provides additional funding for the creation of an online and published DVD curriculum based on the original documentary film and research | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF PITTSBURGH THE | $198,102 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this project is to further disseminate inquiry-based laboratory exercises developed in our SEPA project by (a) adding a Program Coordinator who will double our capacity to conduct in-school visits for student use of the exercises; (b) deplo | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF ARIZONA | $196,295 | Grant | Trans-NIH Recovery Act Research Support: The administrative supplement is for educational product development and is expanding a Virtual Clinical Research Center (VCRC) by accessing resources from the national network of Clinical Research Centers and translational laboratories as well as the Med | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| WAKE FOREST UNIVERSITY | $170,240 | Grant | Trans-NIH Recovery Act Research Support: This Phase I and II application is designed to create and implement programs that better educate students regarding science concepts, the scientific inquiry process, and related careers. The Center of Excellence for Research, Teaching, and Learning (CERTL | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| SAN FRANCISCO STATE UNIVERSITY | $183,096 | Grant | Trans-NIH Recovery Act Research Support: The Spectrum initiative will pioneer a multi-pronged program that brings together K-12 teachers and students with biomedical scientists from multiple stages of the research career pthway to learn together about the biology behind women's health issues, ab | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $108,000 | Grant | Trans-NIH Recovery Act Research Support: ARRA - UNC Framework Program in Global Health Administrative Supplement Funding from a Framework Supplement will support the full implementation of the online Certificate in Fall 2010 and will support instruction for the first three cohorts of certificate | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $39,547 | Grant | Trans-NIH Recovery Act Research Support: A major challenge for the scientific community is to increase the participation of underrepresented minority students in biomedical research and subsequent leadership in the professoriate. For example, less than 10% of students in Case SOM biomedical PhD | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $89,953 | Grant | Trans-NIH Recovery Act Research Support: Acute renal failure (ARF) is an increasingly common complication in hospitalized patients and is associated with extremely high mortality rates. The classical method of assessing renal function by measurement of serum creatinine is insensitive, especially | Health and Human Services, Department of / National Institutes of Health | 8/29/2009 |
| NORTHWESTERN UNIVERSITY | $152,500 | Grant | Trans-NIH Recovery Act Research Support: Stenotrophomonas maltophilia is an environmental bacterium that is implicated in an increasing spectrum of human disease, including infections of the lung, blood, heart, urinary tract, CNS, eyes, skin, and soft tissue. The respiratory tract is the most co | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $157,510 | Grant | Trans-NIH Recovery Act Research Support: The circulating T lymphocyte pool contains multiple antigen-experienced subpopulations bearing distinct tissue tropisms. The two best understood types are those associated with the skin or the intestine. Each subset is responsible for immunological memory | Health and Human Services, Department of / National Institutes of Health | 6/11/2009 |
| LOMA LINDA VETERANS ASSOCIATION FOR RESEARCH AND EDUCATION | $154,000 | Grant | Trans-NIH Recovery Act Research Support: Developing strategies for diagnosis and treatments of the gender specific osteoporosis, which is a major health problem, requires good understanding of the genetic basis of bone development. The objectives of the proposed project is to identify the candid | Health and Human Services, Department of / National Institutes of Health | 8/07/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $147,500 | Grant | Trans-NIH Recovery Act Research Support: Medical research to determine whether low levels of caveolin-1 in their monocytes, fibrocytes, and fibroblasts play a critical role in the susceptibility of idiopathic pulmonary fibrosis and scleroderma patients to lung fibrosis. | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $176,000 | Grant | Trans-NIH Recovery Act Research Support: The differentiation of muscle precursor cells into contractile skeletal muscle fibers is necessary for normal muscle development and regeneration and, when defective, leads to musculoskeletal diseases such as muscular dystrophies and muscle tumors. This p | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $157,000 | Grant | Trans-NIH Recovery Act Research Support: Epidemiological studies and clinical observations suggest that persistent chronic inflammation is important in prostate carcinogenesis. The chronic inflammatory lesions frequently observed in prostate tissue biopsies and radical prostatectomy specimens ar | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| EAST TENNESSEE STATE UNIVERSITY | $155,499 | Grant | Trans-NIH Recovery Act Research Support: Survivors of cancer diagnosed during young adulthood (i.e., diagnosed between 18-39 years of age) (SCDYA) are an understudied population and likely have unique concerns and needs and face different challenges than survivors of either childhood or other ad | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF FLORIDA | $146,500 | Grant | Trans-NIH Recovery Act Research Support: Tobacco smoking decreases food intake and weight gain and a high percentage of smokers started smoking to lose weight. Conversely, smoking cessation has been associated with increased food intake and weight gain. Evidence suggests that smoking helps to co | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| UNIVERSITY OF TENNESSEE | $73,500 | Grant | Trans-NIH Recovery Act Research Support: Although advances in the treatment of alcohol and drug dependence have led to major reductions in substance use, relapse remains a prevalent national problem. Commonly espoused theories of relapse and relapse prevention have long suggested that background | Health and Human Services, Department of / National Institutes of Health | 5/04/2009 |
| MCLEAN HOSPITAL CORPORATION, THE | $237,000 | Grant | Trans-NIH Recovery Act Research Support: Methamphetamine (METH) abuse and dependence represent major mental health and law enforcement problems in the US and abroad. PET studies consistently showed chronic reduction in dopamine transporter (DAT) density in the striatum of methamphetamine addicts | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF WASHINGTON | $3,354,300 | Grant | Trans-NIH Recovery Act Research Support: This application from the Institute for Health Metrics and Evaluation addresses NHLBI Participation in NIH Research and Research Infrastructure 'Grand Opportunities' (RC2) (RFA-OD-09-004); NHLBI RC2 topic area 'Novel Methods of Measuring Health Disparitie | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| WASHINGTON UNIVERSITY, THE | $1,905,001 | Grant | Trans-NIH Recovery Act Research Support: Heart failure affects more than 5 million Americans, and strikes over 500,000 new patients each year. Due in the majority of instances to dilated or ischemic cardiomyopathies, heart failure is a classic 'complex disease', i.e. it is multi-factorial and ha | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF MARYLAND | $2,488,503 | Grant | Trans-NIH Recovery Act Research Support: This application addresses the National Center on Minority Health and Health Disparities' (NCMHD's) Social Determinants of Health Initiative high priority area for funding under the NIH Research and Research Infrastructure Grand Opportunity. The project i | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| BROAD INSTITUTE, INC., THE | $6,150,000 | Grant | Trans-NIH Recovery Act Research Support: We propose to collect and analyze the first ever whole exome sequence data from patients with schizophrenia (SCZ, n > 118), bipolar disorder (BPD, n > 118) and controls (n >116). By providing the first comprehensive evaluation of coding variation in in | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $1,641,067 | Grant | Trans-NIH Recovery Act Research Support: The primary goal of this proposal is to develop and implement an innovative consumer research network (CRN) that can advance the research in the science of improving health by creating a consumer based health information technology (HIT) infrastructure th | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF WASHINGTON | $1,869,398 | Grant | Trans-NIH Recovery Act Research Support: 1.0This application Abdominal Symptom Phenotype: Pathways to New Biomarkers (ASPPNB)is in response to RFA-OD-09-004, American Recovery and Reinvestment Act for research and infrastructure. This application is responsive to NINR priorities related to disco | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| FLORIDA STATE UNIVERSITY, THE | $941,894 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (03) Biomarker Discovery/Validation and specific Topic 03-MH-101: Biomarkers in Mental Disorders. The proposed research takes a construct-oriented approach to the identification of biomarkers for prevalent f | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| TEXAS HEART INSTITUTE | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: Title: Prostacyclin-secreting Cells as Therapy for Pulmonary Artery Hypertension Description: Pulmonary arterial hypertension is a rare but fatal disease, and current therapies are not curative and are associated with significant drawbacks. As part of a | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | $150,000 | Grant | Trans-NIH Recovery Act Research Support: The specific Aim of this 2 year project is to characterize the UPR induced by CS in several lung cells involved in the pathogenesis of COPD, i.e., airway epithelial cells and alveolar pneumocytes. We will test the hypotheses that: 1) the UPR response to | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $437,000 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The instrument described in this application is a matrix-assisted laser desorption ionization (MALDI) tandem time-of-flight (TOF/TOF) mass spectrometer. The proposed instrument will be a part of the shared mass spectro | Health and Human Services, Department of / National Institutes of Health | 4/27/2009 |
| UNIVERSITY OF MONTANA SYSTEM | $415,821 | Grant | Trans-NIH Recovery Act Research Support: The instrumentation will facilitate biomedical research in three research centers at The University of Montnan with focuses in neurobiology, environmental health, and biomolecular structure and dynamics, respectively. NIH-funded investigators at The Univ | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $431,000 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this proposal is to advance our knowledge by employing imaging techniques using small animal MicroCT (Inveon MicroCT). This instrument has high resolution (27 microns) and will be most suitable for small animal investigators at Unive | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| UNIVERSITY OF ILLINOIS | $127,751 | Grant | Trans-NIH Recovery Act Research Support: A shared FTMS instrument upgrade to further biomolecular research at UIC. The instrument is used at the Proteomics and Infomatics Facility at the Research Resources Center. | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $477,304 | Grant | Trans-NIH Recovery Act Research Support: Acquisition of a Bruker X8 Prospector Protein X-ray Crystallography System | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY | $120,670 | Grant | Trans-NIH Recovery Act Research Support: Currently, the functional neuroimaging research conducted and supported by the Laboratory of Neuroimaging at the Mount Sinai School of Medicine utilizes fMRI as a primary measure. fMRI is the hallmark of spatial resolution amongst functional neuroimaging | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | $500,000 | Grant | Trans-NIH Recovery Act Research Support: A 500 MHz solid-state NMR spectrometer is requested in order to replace an aging 360 MHz NMR instrument that was purchased in 1989. This NMR instrument currently supports four areas of NIH-funded biomedical research at Stony Brook University that rely on | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $415,000 | Grant | Trans-NIH Recovery Act Research Support: The aim of this proposal is for the Case Western Reserve University (Case Comprehensive Cancer Center) to acquire an imaging cytometer, the Amnis ImageStream to expand the flow cytometry capabilities at the Case Comprehensive Cancer Center, Case Western R | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| TEMPLE UNIVERSITY | $134,550 | Grant | Trans-NIH Recovery Act Research Support: This award supports acquisition of an animal neuroimaging package which will allow us to adapt a brand new state-of-the-art human 3 Tesla MRI scanner for small animal neuroimaging. We will obtain customized rat and mouse coils fully compatible with our | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $1,954,823 | Grant | Trans-NIH Recovery Act Research Support: For applications in biodefense, it is desirable for small molecule inhibitors to target multiple category A C agents because it is difficult and expensive to develop even one small molecule inhibitor. We propose to develop inhibitors of Holliday junction | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON | $1,895,757 | Grant | Trans-NIH Recovery Act Research Support: Small animal models of infectious disease play a central role in research programs aimed at identifying leads and approaches that could be exploited to devise improved diagnostics, pre-treatments and therapies against bioterrorism agents. However, the fur | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $1,259,770 | Grant | Trans-NIH Recovery Act Research Support: In this project, we will engineer Morburgvirus glycoprotein GP for high-leve,. homogeneous expression, and crystallizability. Any crystals obtained will be tested for X-ray diffraction, with the ultimate goal of provision of a crystal structure of marburg | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC. | $486,934 | Grant | Trans-NIH Recovery Act Research Support: One of the major unsolved problems in drug delivery is how to transport poorly permeable molecules across membrane barriers. The way that Nature solves this problem is through membrane trafficking; cell impermeable ligands such as the iron-carrying transf | Health and Human Services, Department of / National Institutes of Health | 5/13/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $105,520 | Grant | Trans-NIH Recovery Act Research Support: The parasitic protozoan, Trypanosoma brucei, is the causative agent of sleeping sickness in humans and nagana in domestic livestock. Sleeping sickness is invariably fatal if left untreated. Current drugs are ineffective and toxic, and drug resistance is o | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| ST. JUDE CHILDREN'S RESEARCH HOSPITAL | $105,520 | Grant | Trans-NIH Recovery Act Research Support: Infection by pandemic strains of influenza A virus, as well as the currently circulating H5N1 avian strains, results in a high rate of lethality, primarily due to the excessive accumulation of proinflammatory cytokines/chemokines that precedes cellular in | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $51,710 | Grant | Trans-NIH Recovery Act Research Support: FELLOW:WEST, JOHN-KSHV Modulation of the Host Innate Immune System The goal of this project is to determine how the immune system detects KSHV and the signaling pathways that are induced by the Toll-like receptors in response to KSHV infection in differe | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $97,684 | Grant | Trans-NIH Recovery Act Research Support: Giardiasis is an important cause of waterborne illness resulting from a one-celled microscopic parasite, Giardia intestinalis (also known as Giardia lamblia). The pathogenic cyst form is protected by an outer shell and can survive outside the body in the | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| THE JACKSON LABORATORY | $2,101,800 | Grant | National Center for Research Resources, Recovery Act Construction Support: The proposed project will provide the necessary office and training space to support the expansion of The Jackson Laboratory?s Bioinformatics Biology programs and increase the group?s ability to carry out the collaborations anand informal interactions that ... Show more | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $97,684 | Grant | Trans-NIH Recovery Act Research Support: Cholera, which is caused by ingestion of the Gram-negative pathogen Vibrio cholerae, persists worldwide and affects many thousands of people each year, most of whom do not have access to clean water and sanitary conditions. This disease, characterized by | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $102,208 | Grant | Trans-NIH Recovery Act Research Support: Mycobacterium tuberculosis (Mtb) is the leading cause of pathogenic infectious disease mortality worldwide. Roughly one-third of the worldG??s population is infected with Mtb and nearly two million people die from this disease per year. Thus, there is a c | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $37,744 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Intracellular pathogens exploit a variety of host factors enabling them to proliferate and cause an array of infections. Listeria monocytogenes is an intracellular pathogen that is able to escape the bacteriocidal envi | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $97,684 | Grant | Trans-NIH Recovery Act Research Support: Ebola virus (EBOV) infection of humans often results in severe hemorrhagic fever which is lethal in up to 90% of infected cases. Therefore, understanding the molecular mechanisms of Ebola virus pathogenesis is essential for development of successful thera | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UTAH STATE UNIVERSITY | $454,357 | Grant | Trans-NIH Recovery Act Research Support: Laboratory Animal Resource Improvements- Utah State University The Laboratory Animal Research Center (LARC) is the only facility on the Utah State University (USU) campus available for the housing and care of laboratory animals. The objective of the LARC | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| NORTHWESTERN UNIVERSITY | $500,000 | Grant | Trans-NIH Recovery Act Research Support: The Center for Comparative Medicine (CCM) supports the research, teaching and testing activities of Northwestern University (NU) faculty using animals. CCM provides the care for and oversees the humane use of animals, houses research animals, maintains su | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO | $475,781 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to maximize investigator utilization of a newly created Comprehensive Facility for Animal Imaging Research (CFAIR) of the Research Imaging Center (RIC) at the University of Texas Health Science Center at San Antonio (UTHSCSA). | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) | $500,000 | Grant | Trans-NIH Recovery Act Research Support: To remove our existing non-functional bottle washer and old poorly functioning Basil Rack washer; upgrade cage wash supplying electrical, steam and exhaust systems so as to accommodate a new Large Walk-in sterilizer and Tunnel Washer. After upgrading inf | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | $859,500 | Grant | Trans-NIH Recovery Act Research Support: The proposed studies are focused upon identifying and inhibiting the pathogenic process by which a high-fat or western-style, diet evokes Type 2 diabetes, using the mouse model of this common mammalian syndrome. Preliminary work completed supports the hyp | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC. | $647,650 | Grant | Trans-NIH Recovery Act Research Support: Inflammatory bowel disease (IBD) is a chronic inflammation of the GI tract that includes Crohn's disease and ulcerative colitis. The major enzymes involved in mediating the inflammatory response in IBD are cyclooxygenase (COX), lipoxygenase (LOX) and nitr | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $102,208 | Grant | Trans-NIH Recovery Act Research Support: Ruth L. Kirschstein National Research Service Award (NRSA) for Individual Postdoctoral Fellows (F32) award. This NRSA mechanism provides a stipend, tuition and fees, and an institutional allowance.The purpose of this award is to provide support to postdoc | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| BAYLOR COLLEGE OF MEDICINE | $51,710 | Grant | Trans-NIH Recovery Act Research Support: How do amoebae detect and kill bacteria? Free-living amoebae prey upon diverse species of microbes in nature, including some that infect humans. The antagonistic dynamics of this processG??microbial resistance and amoeba counter-resistanceG??has led to | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| YALE UNIVERSITY | $97,684 | Grant | Trans-NIH Recovery Act Research Support: Coxiella burnetii is a Gram-negative, obligate intracellular bacterium that is the causative agent of Q-fever in humans and is further classified as a Class B select agent. After uptake by a host cell, C. burnetii subverts specific host cell processes and | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $181,944 | Grant | Trans-NIH Recovery Act Research Support: The award supports work for a proposed research project: G?Using a population-cased approach to investigate whether genetic inflammation markers and/or use of nonsteroidal anti-inflammatory drugs NSAIDS) predicts motor and non-motor progression in Parkins | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $30,407 | Grant | Trans-NIH Recovery Act Research Support: This grant, a summer supplement to the project - Systems-Based Consortium for Organ Design and Engineering: Polony Multiplex Analysis of Gene Expression Technology Development,provided a summer research experience for 1 science educator and 1 college stud | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| WORCESTER POLYTECHNIC INSTITUTE | $69,362 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of the current project (2 R15 GM069562-02) is to develop a fundamental understanding of the regulatory control of terpene production in Artemisia annua so that in planta metabolic manipulation of terpenoid biosynthesis can eventually be | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| SAN DIEGO STATE UNIVERSITY FOUNDATION | $33,010 | Grant | Trans-NIH Recovery Act Research Support: Chemosensory Perception and Psychophysics in the Aged- Administrative Supplement to parent grant 55736A 'Chemosensory Perception and Psychophysics in the Aged. Funding is provided under ARRA supplement to support undergraduate research assistants to prom | Health and Human Services, Department of / National Institutes of Health | 6/22/2009 |
| UNIVERSITY OF ARKANSAS SYSTEM | $79,170 | Grant | Trans-NIH Recovery Act Research Support: We respectfully request administrative supplemental support to provide summer research experiences for students and science educators. Specifically, we plan to employ one pre-baccalaureate undergraduate and one post- baccalaureate graduate student plus on | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| YALE UNIVERSITY | $34,188 | Grant | Trans-NIH Recovery Act Research Support: Project Narrative Herpes simplex virus-2 (HSV-2), a causative agent of genital herpes, is a highly prevalent (45 million in the USA alone) sexually transmitted infection. Once acquired, HSV-2 causes a life-long incurable debilitating disease for which no | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC. | $91,589 | Grant | Trans-NIH Recovery Act Research Support: Herpes simplex virus (HSV) is a common and significant pathogen which causes a variety of disease processes in humans, ranging from cold and genital sores to Herpes simplex virus (HSV) is a common and significant pathogen which causes a variety of disease | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $230,384 | Grant | Trans-NIH Recovery Act Research Support: Title: 'Gender Bias in Lupus: Contribution of Sex Chromosomes' Autoimmune diseases that cause chronic damage to almost every organ in the body are more common in women than men. For example, systemic lupus erythematosus (SLE) is 9-times more common in fem | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | $119,956 | Grant | Trans-NIH Recovery Act Research Support: Our parent R01 grant (5R01CA109345-05), which will end on June 30, 2009, proposes to investigate the molecular mechanism by which retinoid X receptor-alpha (RXR?) acts in the cytoplasm in response to 15-Deoxy-?12,14-prostaglandin J2 (15d-PGJ2) and analogs | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| CALIFORNIA INSTITUTE OF TECHNOLOGY | $8,040 | Grant | Trans-NIH Recovery Act Research Support: This is a request for an ARRA Administrative Supplement for support of summer undergraduate researchers whose work will assist in attainment of the aims of the Program Project Grants 2P01HD037105 Egg to Embryo: Gene Regulator Circuitry in Development. T | Health and Human Services, Department of / National Institutes of Health | 7/09/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $28,350 | Grant | Trans-NIH Recovery Act Research Support: This award provides summer research experiences for undergraduate students on project involving DNA virus as vectors for cardiovascular diseases. The program has three important components: 1) an intense, hands on research experience working closely with | Health and Human Services, Department of / National Institutes of Health | 6/10/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $150,000 | Grant | Trans-NIH Recovery Act Research Support: Cigarette smoke (CS) is well known to induce chronic obstructive pulmonary disease (COPD) and cancer in humans. Cadmium is the most abundant toxic heavy metal that is present in CS. Cadmium is also present in contaminated air, food and water. Cadmium inha | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $157,000 | Grant | Trans-NIH Recovery Act Research Support: Our goal is to analyze a range of disease severities. The database provides a unique resource to obtain a large number of multi-variate datasets for correlation analysis. The sample size in each subgroup is approximate, depending on data availability and | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| UNIVERSITY OF CHICAGO, THE | $156,000 | Grant | Trans-NIH Recovery Act Research Support: Background: Interstitial lung disease (ILD) encompasses a broad range of chronic lung disorders. The mechanisms of pathogenesis for the development of this disease are mostly unknown. It is widely believed that genetic factors play an important role in th | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $152,958 | Grant | Trans-NIH Recovery Act Research Support: The goal of this proposal is to determine whether postnatal maternal care can moderate the effects of prenatal exposure to maternal stress on infant/toddler development. Accumulating data indicate that prenatal exposure to maternal psychosocial stress and | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| UNIVERSITY OF MIAMI | $956,250 | Grant | Trans-NIH Recovery Act Research Support: The mean time to reperfusion of acute myocardial infarction (AMI) patients in the USA is 3-4h. The metabolic activity within the ischemic tissue over this period is a major determinant of outcome and is critically influenced by the glycemic and insulin-r | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| GENERAL ELECTRIC COMPANY | $1,613,729 | Grant | Trans-NIH Recovery Act Research Support: Driven by advances in electronic miniaturization, probe construction techniques and computing power, medical ultrasound is experiencing a trend toward smaller, lower cost systems with real-time volumetric imaging capabilities. These new attributes provide | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $915,476 | Grant | Trans-NIH Recovery Act Research Support: There are ~5 million heart failure patients in the United States. Over half are estimated to have diastolic heart failure or heart failure with normal or near normal left ventricular ejection fraction. Most diastolic heart failure patients are older adult | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF IOWA, THE | $418,403 | Grant | Trans-NIH Recovery Act Research Support: Stimulant abuse (including both cocaine and amphetamines) is a serious public health problem. There are thought to be over 3 million current users of these drugs in the United States, and these drugs account for numerous emergency room visits each year. A | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $75,227 | Grant | Trans-NIH Recovery Act Research Support: Preventing childhood obesity is considered one of the most compelling public health challenges of our time and demands innovative approaches to tackle. An especially novel approach to confronting the obesity epidemic is promoting consumption of the school | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| BAYLOR COLLEGE OF MEDICINE | $107,259 | Grant | Trans-NIH Recovery Act Research Support: Clinical Outcomes and Survival in Glioma Patients: The third aim of the parent grant will examine markers of clinical outcome and survival. As discussed below, this analysis is heavily dependent on having detailed treatment and follow-up data for each ca | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| ECOHEALTH ALLIANCE INC. | $49,994 | Grant | Trans-NIH Recovery Act Research Support: The award has been used to expedite the testing of clinical bat samples from Bangladesh under Dr. Epstein's original K08 award. We hired a full-time lab technician named Maria Sanchez who is based at the Center for Infection and Immunity at Columbia Univ | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $50,000 | Grant | Trans-NIH Recovery Act Research Support: The dimorphic fungi are the most common cause of invasive fungal disease worldwide, causing several million new infections each year. In the soil, these fungi grow as mold, which produce spores or infectious particles; when inhaled into the lungs of a ma | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| ROCKEFELLER UNIVERSITY FACULTY AND STUDENTS CLUB INC, THE | $50,000 | Grant | Trans-NIH Recovery Act Research Support: I am requesting a supplement request of $100,000 ($50,000 per year in total costs for two years) in order to hire a research assistant who will assist me in performing several key functions that have been outlined in Aim 1 of my funded K08 project, The Pa | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $97,757 | Grant | Trans-NIH Recovery Act Research Support: Despite an increase in the repertoire of cytotoxic and targeted therapies, the prognosis for patients with advanced malignancies remains poor. Recent work has supported a stem cell theory for cancer and suggests that an early tissue specific stem cell is | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $107,996 | Grant | Trans-NIH Recovery Act Research Support: My goal is to become an independent physician-scientist engaged in basic research with clinical relevance. My training thus far in medical oncology and cancer research has laid a strong foundation for an academic career. This grant proposal will enable me | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| UNIVERSITY OF ILLINOIS | $53,881 | Grant | Trans-NIH Recovery Act Research Support: The purpose of the administrative supplement is to provide additional funds for the hire of skilled technical personnel to expedite data collection to accomplish the parent grant research goals and to provide research employment opportunities for rece | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $54,000 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): I am a physician scientist interested in the molecular & cellular mechanisms of acute pancreatitis (AP). My short term career goal is to use a mouse model of CF to investigate why humans with atypical CF develop recurr | Health and Human Services, Department of / National Institutes of Health | 8/12/2009 |
| MAYO CLINIC | $53,950 | Grant | Trans-NIH Recovery Act Research Support: This ARRA Supplement to K08DK76845 Growth Regulatory Mechanisms of KLF in Barrett's Epithelium is a request to expand the personnel support for the aim 3 of K08 to determine the in vivo relevance of KLF11 on the neoplastic transformation in Barrett's muco | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $999,007 | Grant | Trans-NIH Recovery Act Research Support: HISTORIES OF SOCIAL ENGAGEMENT & COGNITIVE FUNCTIONING Research has suggested that greater social engagement G?? a term used to refer broadly to both quantitative and qualitative aspects of social interaction G?? is associated with significantly lower r | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF TENNESSEE | $622,382 | Grant | Trans-NIH Recovery Act Research Support: Because Gram-positive (G+) infections are common and can be life-threatening, it is critical to have a thorough understanding of how these pathogenic bacteria and the various molecules that they release interact with the host immune system. One bacterial | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF TENNESSEE | $487,241 | Grant | Trans-NIH Recovery Act Research Support: In 2008 more than 200,000 American women will be diagnosed with breast cancer and many will be treated with antiestrogens. Unfortunately, many breast tumors initially respond to antiestrogens will become unresponsive over time, leading to metastasis and m | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| THOMAS JEFFERSON UNIVERSITY | $641,176 | Grant | Trans-NIH Recovery Act Research Support: Aim 1. Determine the mechanisms governing DACH1/Eya inhibition of breast tumor cellular proliferation. We will determine the DACH1 binding proteins governing breast tumor growth we will characterize these components in human breast cancer and investigate | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY OF NEBRASKA | $1,028,456 | Grant | Trans-NIH Recovery Act Research Support: To trim the previous 5-year project (lR01EY018380-1A2) for the 2-year funding by the ARRA, here, we propose to test our hypothesis by conduct the following studies. First, we will use molecular and biochemical methods to identify the binding sites in a-cr | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| YALE UNIVERSITY | $661,921 | Grant | Trans-NIH Recovery Act Research Support: Proper functioning of the cell cycle and its regulation in response to both internal and external stimuli is essential for the normal growth, division, and differentiation of cells and tissues. One of the regulators of cell cycle progression is the Anapha | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| YALE UNIVERSITY | $1,301,177 | Grant | Trans-NIH Recovery Act Research Support: This is an efficacy study of an intensive home visitation intervention, Minding the Baby (MTB). This reflective parenting program (aimed at enhancing maternal reflective capacities), is focused on first-time young mothers and their infants living in an ur | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $1,504,655 | Grant | Trans-NIH Recovery Act Research Support: Title: Community-Based Lifestyle Promotion with Latino Women The purpose of this study is to evaluate the feasibility and outcomes of a community-based healthy lifestyle behavior intervention (LSBI), delivered by promotoras, to middle-aged Latinas who a | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $857,971 | Grant | Trans-NIH Recovery Act Research Support: METABOLIC OSCILLATIONS IN HEART Efficient coupling of energy production to energy needs is critical for the beating heart, and factors disrupting this relationship are likely to promote injury. Glycolytic oscillations have been characterized extensively | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $1,228,875 | Grant | Trans-NIH Recovery Act Research Support: EUREKA Award: Preventing the Incidentalome. The project's scope is to determine whether mutations commonly thought to be pathogenic are in fact not so in the general population. | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $678,000 | Grant | Trans-NIH Recovery Act Research Support: The collection of newly discovered clinically valuable genetic tests is far outpacing our ability to use clinical trials to determine their clinical efficacy and determine which of the collection of tests and associated algorithms are best suited for any | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| YALE UNIVERSITY | $870,314 | Grant | Trans-NIH Recovery Act Research Support: BCL-xL is the major anti-cell death BCL-2 family member expressed in brain, and understanding its function is key to designing strategies for neuroprotection. In this application, we will attempt to prove that inhibition of BCL-xL or down regulation of ex | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $2,366,335 | Grant | Trans-NIH Recovery Act Research Support: This is a multi-PI RO1 grant designed to use multiple mouse genetic models of neural tube defects (NTDs, spina bifida and anencephaly) to investigate genetic factors confering NTD risk. Investigations will study how those gene mutations interact with envi | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $837,468 | Grant | Trans-NIH Recovery Act Research Support: Cardiovascular disease (CVD) is the leading cause of death in the western world. However, why some individuals with identical risk factor profiles will go on to develop CVD, whereas others will not, is simply not understood. One explanation is that CVD is | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $154,000 | Grant | Trans-NIH Recovery Act Research Support: Exposure to ultraviolet radiation (UVR) is one of the primary modifiable risk factors for development of melanoma with exposures occurring early in life believed to be most critical. The relationship between UVR exposure and family history has not been we | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $330,796 | Grant | Trans-NIH Recovery Act Research Support: The overarching goal of this study is to test the role of pain, illicit drug use, and symptoms of depression and anxiety in the misuse of opioids and psychoactive medications within an existing cohort of men who have sex with men (MSM) participating in th | Health and Human Services, Department of / National Institutes of Health | 5/04/2009 |
| UNIVERSITY OF TENNESSEE | $148,000 | Grant | Trans-NIH Recovery Act Research Support: MicroRNAs are a new class of non-coding small RNAs that negatively regulate gene expression by either degrading mRNA or suppressing protein translation. A miRNA cluster, miR-15/16, has been implicated in a variety of human diseases, such as cancer, and em | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| UNIVERSITY OF MASSACHUSETTS | $164,229 | Grant | Trans-NIH Recovery Act Research Support: Before sperm are able to successfully fuse with and fertilize the egg they must successfully migrate through the female reproductive tract and reach the ovulated oocytes. During this migration the sperm undergo Capacitation - defined as the ability to rec | Health and Human Services, Department of / National Institutes of Health | 7/28/2009 |
| CALIFORNIA STATE UNIVERSITY AUXILIARY SERVICES, INC | $144,500 | Grant | Trans-NIH Recovery Act Research Support: The rapid and accurate diagnosis of bacterial pathogens causing diseases and infections has been a goal of clinicians and microbiologists since the discovery of microbes as disease-causing agents. Conventional methods of diagnosis rely upon physiological | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $382,223 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this grant application was to screen chemical and small interfering RNAs (siRNA) libraries to identify chemical probes and siRNAs that modify three distinct arms of IERSR. The probes generated through this effort will be critical for elucid | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $423,500 | Grant | Trans-NIH Recovery Act Research Support: Trypanosomes and related protozoa cause a variety of debilitating diseases in the tropics including Human African Sleeping Sickness, Chagas Disease and various forms of Leishmaniasis. The goal of our work is to study pathways present in the parasite but | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $423,500 | Grant | Trans-NIH Recovery Act Research Support: Trypanosomes and related protozoa cause a variety of debilitating diseases in the tropics including Human African Sleeping Sickness, Chagas Disease and various forms of Leishmaniasis. In the mammalian hosts, regulated gene expression is determined primar | Health and Human Services, Department of / National Institutes of Health | 5/04/2009 |
| UNIVERSITY OF MASSACHUSETTS | $451,625 | Grant | Trans-NIH Recovery Act Research Support: Polymorphonuclear Phagocytes in Malaria Sepsis, Award Number R21AI080907 from the - Institute of Allergy and Infectious Disease, is aimed at investigating that the Myeloid Differentiation Factor 88 (MyD88), an adaptor-signaling molecule for the IL-1 recep | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $366,233 | Grant | Trans-NIH Recovery Act Research Support: This project is aimed at developing a novel approach that quantifies autoantibodies against multiple prostate cancer associated antigens in conjunction with a classic biomarker, PSA. This novel approach may find broad applications in prostate cancer diag | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF ARKANSAS SYSTEM | $329,476 | Grant | Trans-NIH Recovery Act Research Support: Approximately 90% of all deaths from breast cancer arise from metastatic spread of a primary tumor. The failure of current cancer treatment may be explained by a small subset of therapy-resistant and highly metastatic cancer stem cells (CSCs). Although ex | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $344,892 | Grant | Trans-NIH Recovery Act Research Support: Chronic pain disorders may persist in children and adolescents for several years and have significant impact on their physical, social, and academic functioning, with potential long-term reduction in quality of life. A significant obstacle to for treatin | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| YALE UNIVERSITY | $635,962 | Grant | Trans-NIH Recovery Act Research Support: Allergic diseases such as contact sensitivity and delayed type hypersensitivity can be very debilitating and are a rapidly increasing and costly burden on public health systems in the United States. This proposal will develop new technology to facilitate | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF MASSACHUSETTS | $722,700 | Grant | Trans-NIH Recovery Act Research Support: This research is a feasibility study that is organ specific and is aimed at determining the ability of a dedicated breast computed tomography system (herein, referred to as breast CT system) to visualize lesions. Specifically, this research is to demonst | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $536,340 | Grant | Trans-NIH Recovery Act Research Support: The UCLA Racial and Ethnic Minority (REM) HIV/AIDS Translational Training (HATT) Program. Our R25 training grant has developed a research mentorship program for REM postdoctoral fellows and early career investigators interested in studying HIV/AIDS, men | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $192,500 | Grant | Trans-NIH Recovery Act Research Support: This project will identify various response trajectory outcomes in antidepressant-treated Major Depressive Disorder (MDD) patients through the use of statistical growth mixture modeling (GMM), and will also characterize subjects in the various response tr | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $538,000 | Grant | Trans-NIH Recovery Act Research Support: Title: Evaluating an emergency department observation syncope protocol for older adults This application addresses the broad Challenge Area (05): Comparative Effectiveness Research, and specific Challenge Topic: G?05-AG-104. Planning grants and pilot st | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $995,500 | Grant | Trans-NIH Recovery Act Research Support: Identification of Enhancers of Therapeutic Exon Skipping for Duchenne Muscular Dystrophy Duchenne Muscular Dystrophy (DMD) is the most common lethal genetic disease of childhood, occurring in 1 in every 3500 live male births. It is caused by the absence o | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| THOMAS JEFFERSON UNIVERSITY | $997,134 | Grant | Trans-NIH Recovery Act Research Support: This application addresses Broad Challenge Area (09): Health Disparities and Prevention and Specific Challenge Topic, 09-CA-101: The Basis for Differences in Cancer Incidence. There is an established disparity in stage-specific outcomes in African America | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| BIOCARDIA, INC. | $100,000 | Grant | Trans-NIH Recovery Act Research Support: Award title: Endomyocardial catheter delivery of artificial biopolymer matrices for enhanced cell retention in cardiovascular cell based therapy. The overall purpose of this project is to identify formulations of two-component biopolymers including fibri | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| ELI WIENER-AVNEAR | $132,100 | Grant | Trans-NIH Recovery Act Research Support: The objective of the recovery award is to allow LEEOAT Company to develop, design, theoretical model, fabricate and test our innovative volumetric imagers, to support noninvasive real-time guiding of medical catheters during clinical therapeutic procedure | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| REDONDO OPTICS | $149,959 | Grant | Trans-NIH Recovery Act Research Support: The Title of the project is Multiparameter Fiber Optic Breathing Sensor. The goal of this project is to develop a device to detect periodic breathing, or brief central or obstructive apnea, assocaited with hypoxemia for infants at risk of sudden infant d | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $1,013,230 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (05) Comparative Effectiveness Research and Specific Challenge Topic 05 MD105, Health Literacy. After examining feasibility, this intervention compares the use of a patient advocate to promote effective heal | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $907,193 | Grant | Trans-NIH Recovery Act Research Support: There is currently no sensitive noninvasive method for diagnosing preclinical peripheral arterial disease (PAD), which affects 8 million Americans. In this project we propose to implement and evaluate a new noninvasive MRI based method in healthy subjects | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $860,216 | Grant | Trans-NIH Recovery Act Research Support: Using agent-based modeling to develop a robust and well-characterized model of individual-level nutrition and physical activity behaviors, as influenced by social and physical environmental factors. | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF MASSACHUSETTS | $999,154 | Grant | Trans-NIH Recovery Act Research Support: This project directly addressed the broad Challenge Area (06) Enabling Technologies and specific Challenge Topic: Chemist/Biologist collaborations facilitating tool development. The goal of this project is to target the N linked glycans on ion-conducting | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $969,718 | Grant | Trans-NIH Recovery Act Research Support: This project, Prevention Trial of Family Focused Treatment in Youth at Risk for Psychosis, is a multi-site study (UCLA, Yale, Emory, University of North Carolina) testing the efficacy of a family-focused psychosocial intervention in the prevention of func | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: Selective serotonin reuptake inhibitors (SSRIs) have become the mainstream therapy in psychiatric diseases. Based on their therapeutic effect in adults, they are increasingly prescribed in children and adolescents. However, there is a concern about the us | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| YALE UNIVERSITY | $991,807 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (05), Comparative Effectiveness Research and Specific Challenge Topic, 05-MD-102, Prevention of Chronic Diseases in Disparity Populations. Building on our previous research in teens with type 1 diabetes (T1D | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $814,823 | Grant | Trans-NIH Recovery Act Research Support: To study the effects of the curcumin derivative drug CNB-001 on counteracting the brain dysfunction after traumatic brain injury (TBI) CNB-001, a potent synthetic derivative of curcumin, has both neuroprotective and neuronal function enhancing proper | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF TENNESSEE | $2,545,633 | Grant | Trans-NIH Recovery Act Research Support: Cigarette smoking is a pre-eminent public health problem, recognized as early as 1965. The rapid acquisition and addiction to cigarettes during adolescence is at the root of this continuing epidemic. A cardinal feature of smoking is the high level of indi | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| SAN DIEGO STATE UNIVERSTIY FOUNDATION | $4,710,605 | Grant | Trans-NIH Recovery Act Research Support: The study will provide a significant complement to the parent HCHS/SOL study, to help achieve the goal of examining varied risk and protective factors in Hispanic health and will provide much needed information on the role of SES, sociocultural and psycho | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| YALE UNIVERSITY | $2,906,138 | Grant | Trans-NIH Recovery Act Research Support: We will apply whole exome sequencing to discover mutations causing structural brain disease in a large cohort of patients from consanguineous union. Comprehensive discovery of mutations that cause brain malformations holds great promise for advancing unde | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| VETERANS MEDICAL RESEARCH FOUNDATION OF SAN DIEGO | $1,771,712 | Grant | Trans-NIH Recovery Act Research Support: The impact of antiretroviral therapy represents a major demonstration of the capability and success of modern drug discovery, development, and implementation. Nevertheless, in infected individuals this success lasts only as long as adherence to the regime | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $2,303,000 | Grant | Trans-NIH Recovery Act Research Support: Tuberculosis (TB) is a global health problem and it is one of the leading causes of death due to an infectious disease. Increases in drug-resistant TB could reverse the declining trend of TB disease and death. We want to developnew approaches and new tool | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $2,520,000 | Grant | Trans-NIH Recovery Act Research Support: Disease-causing pathogens are among the most intriguing forces shaping human evolution, as they have a tremendous impact on our genome and themselves evolve over time. A genome-wide survey of human variation indentified two genes biologically linked to L | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| WASHINGTON UNIVERSITY, THE | $82,556 | Grant | Trans-NIH Recovery Act Research Support: Alzheimer's Disease (AD) is the leading cause of late-onset dementia and is characterized by progressive cognitive decline and memory loss, ultimately leading to death. Over 5 million Americans are currently suffering from AD, and the total costs of AD an | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| BROWN UNIVERSITY IN PROVIDENCE IN STATE OF RI AND PROVIDENCE PLANTATIONS | $54,444 | Grant | Trans-NIH Recovery Act Research Support: Indiviudual Fellowship Award to study the following: In most cases, proteins adopt a single three-dimensional fold that specifies their functions in vivo. There are several protein quality control pathways that help to ensure that proteins adopt their pr | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON | $58,488 | Grant | Trans-NIH Recovery Act Research Support: While strides have been made to reduce the lethality of septic shock, it is still a highly fatal condition that is on the rise. Immunomodulation may prove to be a viable treatment option for sepsis. Immunomodulation consists of the induction of an immunol | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF HAWAII SYSTEMS | $67,334 | Grant | Trans-NIH Recovery Act Research Support: The goal of the project is to train the applicant in neuroAIDS research as a predoctoral student by studying the role that HIV plays in Causing HIV-associated neurocognitive problems. Dr. Shiramizu will be the mentor for Melissa Agsalda. | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| MEHARRY MEDICAL COLLEGE | $69,151 | Grant | Trans-NIH Recovery Act Research Support: Caveolin-1, an integral membrane protein highly localized to lipid rafts, has been shown to cause marked decrease in HIV-1 protein expression. Caveolae, the plasmalemmal invaginations formed by caveolin oligomerization, are involved in regulation of intra | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF CALIFORNIA, SANTA BARBARA | $64,011 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Addiction to drugs of abuse is an incredible burden to society - costing billions of dollars annually. While it has been long recognized that addiction is a brain disease, the etiology of addiction remains unclear. Re | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| UNIVERSITY OF ARIZONA | $102,208 | Grant | Trans-NIH Recovery Act Research Support: Declines in episodic memory that accompany normal aging are a growing concern for public health as the average lifespan continues to increase. The hippocampus is a critical structure for long-term episodic and semantic memories and receives major input fr | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $97,684 | Grant | Trans-NIH Recovery Act Research Support: Vitamin D3, Autoimmunity and N-Glycosylation: Under the proposed intensive training plan, I will acquire the invaluable scientific skills and knowledge required to achieve a productive, independent scientific career. The Kirschstein-NRSA Individual Fello | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $119,320 | Grant | Trans-NIH Recovery Act Research Support: Eosinophils have long been thought to function exclusively as end stage effector cells in asthma and other eosinophilic lung disorders, acting through the release of cytotoxic substances. However, mounting evidence has demonstrated that eosinophils have i | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| TRUSTEES OF THE UNVERSITY OF PENNSYLVANIA | $50,054 | Grant | Trans-NIH Recovery Act Research Support: All viruses tightly regulate cellular processes to create an environment supportive for replication. An understanding of the mechanisms viruses use to do this is vital for our knowledge of viral pathogenesis as well as the normal cellular controls of thes | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $107,152 | Grant | Trans-NIH Recovery Act Research Support: Shigella is a family of gram-negative bacteria that cause severe infections of the colonic epithelium, leading to an estimated 1.1 million deaths annually. After bacterial entry into host cells, the assembly of host actin into an actin tail at the bacteri | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $4,089,705 | Grant | Trans-NIH Recovery Act Research Support: The key to understanding the results of the STEP/Phambili trials is first to model the results of the trial in controlled experiments using mucosal SIV inoculation of rhesus macaques. Thus, we will determine the effectiveness and potential of the Merck t | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| UNIVERSITY OF ROCHESTER | $518,353 | Grant | Trans-NIH Recovery Act Research Support: The University of Rochester hosts a vibrant, interdisciplinary team of scientists working on projects at the intersection of metabolic regulation and aging. We have identified several areas of competence that would strategically strengthen this group. The | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $924,872 | Grant | Trans-NIH Recovery Act Research Support: This grant mechanism is designed to support the hiring of a newly-recruited faculty member and to develop research projects within the context of Biomedical Core Centers. The award is designed to enhance innovative programs of excellence by providing sci | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $1,559,733 | Grant | Trans-NIH Recovery Act Research Support: This award provides for the recruitment of a scientist dedicated to the basic and translational research of angiogenesis andtumor microenvironment proposed in this application supports three of the scientific priorities of theentities: 1) to understand cr | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF MIAMI | $1,425,014 | Grant | Trans-NIH Recovery Act Research Support: The P30 award will provide critical support for strengthening two of the Cancer Center's seven multidisciplinary research programs. Two candidates are proposed for recruitment-one into the Viral Oncology Program and the other into the Bio-behavioral Oncol | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF CONNECTICUT | $1,816,487 | Grant | Trans-NIH Recovery Act Research Support: Contingency management (CM) interventions are efficacious in improving outcomes of substance abusing patients. With the increasing evidence basis of CM, providers are expressing interest in learning about CM implementation. Currently, no centralized mecha | Health and Human Services, Department of / National Institutes of Health | 7/30/2009 |
| UNIVERSITY OF LOUISVILLE | $201,166 | Grant | Trans-NIH Recovery Act Research Support: Overall purpose:The principal purpose of this supplemental proposal is to develop novel derivatizing agents for labile keto and aldehydic functional groups that will facilitate their mass spectrometric analysis. Metabolites with these functional groups (e | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| YALE UNIVERSITY | $273,850 | Grant | Trans-NIH Recovery Act Research Support: The present administrative supplement will allow us TO HIRE VALERIE GORDON AND KEEP MARY MORGAN TAYLOR IN THE LAB FOR ONE MORE YEAR before they each join graduate school. Valerie has worked in the lab as an undergraduate student for the past 3 years and w | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE | $813,325 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this award is for the renovation of existing satellite laboratory space to accommodate a new in vitro BSL3 facility as part of the overall mission of our COBRE program. The original mission of our COBRE program was the study of the immune | Health and Human Services, Department of / National Institutes of Health | 8/25/2009 |
| NATIONAL BUREAU OF ECONOMIC RESEARCH, INC. | $272,000 | Grant | Trans-NIH Recovery Act Research Support: The goals of the supplement are (1) to accelerate the development of a data access system at the NBER that allows simultaneous use of various country surveys on health and aging that are being conducted around the world, and (2) to enhance the consol | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| NORTHWESTERN UNIVERSITY | $762,500 | Grant | Trans-NIH Recovery Act Research Support: Our overall objective is to understand why the immune system in SLE (lupus) responds abnormally to nuclear autoantigens from cells undergoing physiologically programmed apoptosis, and how this response could be specifically downregulated for effective the | Health and Human Services, Department of / National Institutes of Health | 5/28/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $106,412 | Grant | Trans-NIH Recovery Act Research Support: Chlamydia trachomatis has a marked tissue tropism, replicating almost exclusively in epithelial cells lining the reproductive tract. The Chlamydia muridarum mouse model for human C. trachomatis disease has clearly demonstrated that T cells mediate protect | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $101,797 | Grant | Trans-NIH Recovery Act Research Support: The overall purpose of the award is to determine whether pharmacological Inositol (1 ,4,5) Trisphosphate 3-kinase B (ItpkB)-inhibition could provide an avenue towards cost effectively reducing detrimental T cell function and cytokine storm in swine influe | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $492,000 | Grant | Trans-NIH Recovery Act Research Support: Interferon (IFN) and IFN-stimulated gene products (ISGs) are essential components of the innate immune response to viral infection. Conversely, viruses need to limit the induction or function of ISGs for successful infection of their respective host. One | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $404,479 | Grant | Trans-NIH Recovery Act Research Support: Modeling HIV-1 Eradication Therapies in the hu-Rag2-/-gamma c-/- Mouse Model - A Latently infected memory CD4+ T cells constitute a major reservoir of persistent HIV-1 infection and are a central obstacle to its eradication. Agents must be developed that | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF UTAH, THE | $422,783 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): HIV induces a progressive and often irreversible deterioration of the immune system. Through years of experimentation and observation, we have learned that immune responses to HIV do exist and have a range of effective | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF ILLINOIS | $420,258 | Grant | Trans-NIH Recovery Act Research Support: The g134.5 protein, present in herpes simplex viruses (HSV), plays an essential role in viral virulence. Unlike wild-type virus, HSV mutants that lack the g134.5 gene are incapable of replicating and causing diseases. However, the underlying mechanisms | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $468,420 | Grant | Trans-NIH Recovery Act Research Support: Evident in its name, Helicobacter pylori is a helical bacterium that colonizes the human stomach causing clinical outcomes that range from mild gastritis to peptic ulcer and gastric cancer. We discovered genes that promote spiral shape by this bacterium c | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $494,571 | Grant | Trans-NIH Recovery Act Research Support: MicroRNAs (miRNAs) are genomically-encoded small RNAs (~ 21 nts) that bind to target mRNAs in a sequence-specific manner to regulate their translation and/or decay. In addition to its role in regulating cholesterol and fatty acid metabolism, the abundant | Health and Human Services, Department of / National Institutes of Health | 5/28/2009 |
| UNIVERSITY OF MARYLAND | $375,000 | Grant | Trans-NIH Recovery Act Research Support: Cystic fibrosis (CF) is an inherited lung disease characterized by mucus hypersecretion, reduced mucociliary clearance of inhaled bacteria, particularly Pseudomonas aeruginosa (PA), and chronic airway inflammation. While the exact molecular mechanisms lea | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| MONTANA STATE UNIVERSITY, INC | $391,875 | Grant | Trans-NIH Recovery Act Research Support: This project examines the enhanced immunological protection in the lung that is associated with pre-existing iBALT (inducible bronchus-associaed lymphoid tissue) structures in the lung. The focus of the research will be on the enhanced B cell development | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| UNIVERSITY OF PITTSBURGH THE | $416,625 | Grant | Trans-NIH Recovery Act Research Support: Tuberculosis(TB), caused by the organism M.tuberculosis (Mtb), kills more than 2 million people worldwide every year(1). Our limited understanding of how vaccine responses mediates protection in the lung remains a major hurdle to successful vaccine desig | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $451,000 | Grant | Trans-NIH Recovery Act Research Support: The major functions of the gut epithelial compartment in a complex organism is to provide a protective barrier from pathogenic organisms that gain entry through the GI tract as well as facilitate the absorption and distribution of needed nutrients. These | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF ILLINOIS | $431,750 | Grant | Trans-NIH Recovery Act Research Support: The clinical success of macrolide antibiotics has been curbed due to the spread of resistance. One of the major resistance mechanisms found in pathogenic strains is the modification of the drug-target, the ribosome, by Erm methyltransferase enzymes. The e | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| UNIVERSITY OF TEXAS AT DALLAS | $773,299 | Grant | Trans-NIH Recovery Act Research Support: Perhaps the most urgent scientific challenge for the 21st century is to develop interventions to slow the process of cognitive aging so that at the end of life, most older adults are in control of their mental faculties and they and their families can enj | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| COLORADO STATE UNIVERSITY | $978,779 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (15) Translational Science and specific Challenge Topic, 15-AI-102*: Develop diagnostics and drugs for multiple or extensively drug-resistant tuberculosis (MDR/XDR TB). Mycobacterium tuberculosis (M. tb), th | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| OREGON STATE UNIVERSITY | $993,068 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (15) Translational Science, and specific Challenge Topic, 15-AI-106: Translational research focused on high priority pathogens and basic research focused on resistance mechanisms. Infections by Chlamydia tra | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF FLORIDA | $839,690 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to develop a way to observe whether or not new therapies are effective in correcting the disease process in muscles of boys with Duchenne muscular dystrophy (DMD) without the need to take muscle biopsies. We will extend our pas | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: The systemic vasculitides are a group of diseases characterized by severe inflammation of blood vessels leading to arterial stenosis or occlusion, and organ damage or death if untreated. Two related vasculitides, Wegener's granulomatosis (WG) and microsco | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| OKLAHOMA MEDICAL RESEARCH FOUNDATION | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: The awarded project is aimed at performing a genome-wide association scan on 600 individuals with systemic lupus erythematosus of Hispanic ancestry and 200 healthy controls. The aim is to search in particular for risk variation of Amerindian origin. Micro | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| WASHINGTON UNIVERSITY, THE | $997,798 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (06) Enabling Technologies and specific Challenge Topic: 06-AR-103, Systems Biology for Skin and Rheumatic Diseases. Psoriasis (PS) is a complex inflammatory skin disease where genetic risk factors and envir | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $548,978 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (05) Comparative Effectiveness Research and specific Challenge Topic, 05-AR-102: Comparative Effectiveness (CE) of Treatments for Chronic Childhood Arthritis and Musculoskeletal (MSK) and Skin Disease. Infan | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF UTAH, THE | $966,971 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (15) Translational Science and specific Challenge Topic, 15- OD(ORDR)-101: Pilot projects for prevention, early detection and treatment of rare diseases. Current technolo | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $834,573 | Grant | Trans-NIH Recovery Act Research Support: Role of Advanced Screening Technologies for Early Detection of Breast Cancer Project Summary/Abstract This application addresses broad Challenge Area (05): Comparative Effectiveness Research and specific Challenge Topic, 05-CA-105 CISNET (The Cancer Inter | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF FLORIDA | $781,049 | Grant | Trans-NIH Recovery Act Research Support: Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting over 2.5 million Americans at a cost of over 7 billion dollars per year to Medicare alone. Importantly, 15% of all strokes are attributed to atrial fibrillation with the atrial appe | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| TEXAS A&M UNIVERSITY SYSTEM,THE | $402,875 | Grant | Trans-NIH Recovery Act Research Support: We recently demonstrated that soon after Bacillus anthracis spores are delivered into mouse lungs significant quantities of these spores are found inside the lung epithelial cells. Here we hypothesize that this intracellular presence plays an important ro | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $742,033 | Grant | Trans-NIH Recovery Act Research Support: More than 2 million children and youth in the U.S. are homeless at some time each year. Once on the streets, homeless youth frequently rely on high-risk survival behaviors to meet their basic needs. Compounding these high-risk behaviors, these youth also | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| DREXEL UNIVERSITY | $77,708 | Grant | Trans-NIH Recovery Act Research Support: Developing neurons undergo complex changes in gene expression that translate into mechanistic differences in how the neuron functions. The majority of studies aimed at understanding the mechanisms of axon extension, as they relate to regenerative attempts | Health and Human Services, Department of / National Institutes of Health | 9/20/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $77,708 | Grant | Trans-NIH Recovery Act Research Support: The pancreatic ?-cells are responsible for producing insulin and maintaining glucose homeostasis. A loss of ?-cells or their inability to compensate for insulin resistance is the major cause for type I and type 2 diabetes, respectively. Increasing ??cell | Health and Human Services, Department of / National Institutes of Health | 9/19/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $75,600 | Grant | Trans-NIH Recovery Act Research Support: Abstract Serotonin (5-hydroxytryptamine; 5HT) has been demonstrated to play important roles in various physiological functions such as mood, sexual behavior, feeding, sleep/wake cycle, memory, cognition, blood pressure regulation and breathing (Mooney et | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| PLUROGEN THERAPEUTICS, INC | $99,615 | Grant | Trans-NIH Recovery Act Research Support: Chronic wounds, such as diabetic wounds, are a major global health and economic burden. In the United States alone, 10.8 million chronic wounds occur every year (de Zoysa et al., 2005) which is estimated to cost over $15 billion annually in the U.S. (Farl | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| INDIANA NANOTECH, LLC | $102,110 | Grant | Trans-NIH Recovery Act Research Support: The worldwide market for implant-based dental products is forecasted to approach $3.5 billion by 2010, and although only 9% of the global dental market is allocated to dental implants, it is the fastest growing segment at a rate of 15% per year. These pro | Health and Human Services, Department of / National Institutes of Health | 8/15/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $240,726 | Grant | Trans-NIH Recovery Act Research Support: Antigenically-na+?ve CD4 T cells expressing alpha/beta-T-cell receptors are critical for generating immune responses to neoantigens, and are produced de novo within the thymus as mature CD4+CD8- thymocytes. These enter the periphery to become recent thymi | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| DUKE UNIVERSITY | $608,021 | Grant | Trans-NIH Recovery Act Research Support: To survive within the hostile environment of the infected host, pathogenic microorganisms must be able to sense and adapt to changing environmental conditions. This adaptation requires a coordinated regulation of multiple factors for growth and survival. | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| UNIVERSITY OF IOWA, THE | $371,938 | Grant | Trans-NIH Recovery Act Research Support: The host response to pathogenic insults involves complex inflammatory responses and cellular immune reactions, such that the decision to generate protective immunity or tolerance often depends on the context in which T cells first encounter antigen (Ag). | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $799,977 | Grant | Trans-NIH Recovery Act Research Support: As new HIV infections continue to occur at alarming rates, development of a strong and effective mucosal vaccine would have a huge public health impact. Thus there is a continuing need for new approaches for HIV-1 vaccination. This project focuses on the | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF TOLEDO, THE | $372,010 | Grant | Trans-NIH Recovery Act Research Support: Streptococcus Pneumoniae is the most common bacterial respiratory pathogen in human immunodefficiency virys (HIV) infected persons. The incidence of Pneumococcal disease is significantly elevated, 35 -100 folds, in HIV-positive population. Purpose of this | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $432,156 | Grant | Trans-NIH Recovery Act Research Support: Bacillus anthracis, the causative agent of anthrax, is a highly pathogenic bacterium considered to be a serious threat as an agent of bioterrorism. The recent use of this bacterium as a terrorist weapon in the United States exposed the need for a more ef | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| NORTH CAROLINA STATE UNIVERSITY | $358,752 | Grant | Trans-NIH Recovery Act Research Support: Our overall goal is to identify novel components of the host innate antiviral response and novel mechanisms by which viruses subvert this response to cause disease. Cardiac myocytes are non-replenishable; thus the heart is unusually dependent on this firs | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| PACIFIC NORTHWEST RESEARCH INSTITUTE | $218,750 | Grant | Trans-NIH Recovery Act Research Support: Taken from Grant Abstract - Understanding the interplay between pancreatic alpha- and beta-cells that exerts local control on glucagon secretion is the focus of this application. Blood glucose levels are controlled primarily by two hormones, insulin, whi | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $185,431 | Grant | Trans-NIH Recovery Act Research Support: The objective of the project is to evaluate the role of protein carbonylation in mitochondrial dysfunction and insulin resistance in adipocytes. | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| THE HOSPITAL FOR SPECIAL SURGERY FUND INC | $715,461 | Grant | Trans-NIH Recovery Act Research Support: Revision total joint arthroplasty (rTJA) for the hip or knee joint is a complex, costly procedure. Approximately 83,000 are performed annually in the US (2006 estimate). The frequency of these revision procedures is only expected to increase with the la | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| AUBURN UNIVERSITY | $986,258 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this study is to examine whether the manner in which parents interact with their preschool children and parents' and children's responses to stress, in combination with how they think about stressful social situations, influence the child' | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $996,672 | Grant | Trans-NIH Recovery Act Research Support: This application addresses the broad Challenge Area (04) Clinical Research and the NIA specific Challenge Topic 04-AG-105: Development of experience-based measures of well-being. There is an interdisciplinary resurgence of interest in the correlates and c | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | $968,509 | Grant | Trans-NIH Recovery Act Research Support: This ARRA Challenge Grant application addresses Broad Challenge Area (05) - Comparative Effectiveness Research and Specific Challenge Topic 05-AG-105 - Comparative Intervention Trials for Diseases and Syndromes of Aging Including Neurodegenerative Disease | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF ARIZONA | $806,619 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (06) Enabling Technologies and Specific Challenge Topic, 06-AG-101: Neuroscience Blueprint: Development of non-invasive imaging approaches or technologies that directly assess neural activity. As the title o | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: Epigenetic Analysis of iPS Cell Models of Aging and AlzheimerG??s Disease The overall purpose of this award is to advance our understanding of cognitive decline associated with aging and AlzheimerG??s disease (AD). The award will promote this goal through | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF ILLINOIS | $811,890 | Grant | Trans-NIH Recovery Act Research Support: The goal of this study is to examine the hypothesis that alterations in neurogenesis occur in a specific manner in AlzheimerG??s disease and are manifested by an imaging-detectable impairments and by alterations in neurogenic gene expression. This hypothe | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $989,410 | Grant | Trans-NIH Recovery Act Research Support: This Challenge grant application addresses the Broad challenge area: translational science: Specific challenge topic: 15-NS-103. Demonstration of proof of concept for a new therapeutic approach in a neurological disease. Our goal is to utilize a new conce | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad challenge area (15) Translational Science and specific Challenge Topic, 15-AI-106: translational research focused on high priority pathogens and basic research focused on resistance mechanisms. The research described herei | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| THE GEORGE WASHINGTON UNIVERSITY | $721,525 | Grant | Trans-NIH Recovery Act Research Support: Tuberculosis (TB) is one of the worldG??s deadliest infectious diseases, and co-infection with HIV plus the emergence of drug-resistance have made TB both difficult and expensive to treat. In order to create new TB drugs, we need to understand how best t | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF OREGON | $759,988 | Grant | Trans-NIH Recovery Act Research Support: Neglected tropical diseases are a group of 13 major disabling conditions that are among the most common chronic infections in the world's poorest people. Chief among these are the five main diseases caused by nematode worms, accounting for more than 80% | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| OKLAHOMA MEDICAL RESEARCH FOUNDATION | $999,740 | Grant | Trans-NIH Recovery Act Research Support: Autoimmune diseases are estimated to afflict as many as 50,000,000 Americans. This proposal tests genetic and serologic biomarkers of autoimmunity, cytokine activity, and abnormal environmental responses as predictors of autoimmune disease onset. Biospeci | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $974,414 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (04) Clinical Research and specific Challenge Topic 04-AR-101 Autoimmunity for Diseases of Skin, Joints, Muscles and Other Tissues. It is estimated that approximately 5% of the US population is affected by a | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| HARTFORD HOSPITAL | $865,207 | Grant | Trans-NIH Recovery Act Research Support: Statins markedly reduce the incidence of cardiac events. These drugs are generally well-tolerated but can produce a dose-related myopathy with symptoms ranging from ?mild? myalgia, muscle cramps and weakness to life-threatening rhabdomyolysis. Rhabdomyoly | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $997,784 | Grant | Trans-NIH Recovery Act Research Support: This application addresses Challenge Area (01) Behavior, Behavioral Change, and Prevention and Specific Challenge Topic, 01-CA-103, The Role of Health Behaviors in Cancer Prevention. Research shows that telephone quitlines are effective smoking cessation | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF TENNESSEE | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: Modulation of cancer prevention by social stress'. This project will test the hypothesis in xenografts of the human lung adenocarcinoma cell lines NCI-H322 (with ras mutations) and NCI-H441 (without ras mutations) and the human pancreatic ductal adenocarc | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| THE VANDERBILT UNIVERSITY | $774,959 | Grant | Trans-NIH Recovery Act Research Support: Head and neck squamous cell carcinoma (HNSCC) is a devastating disease that is treated aggressively when diagnosed at late stages. Treatment includes at least two and at times all three modalities of surgery, radiation, and chemotherapy. Due to the critic | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF MARYLAND | $930,338 | Grant | Trans-NIH Recovery Act Research Support: The development of hormone resistance in breast cancer is a significant clinical problem. The enhanced expression of the ErbB2/3 heterodimer leads to the ability of breast cancer cells to bypass normal endocrine responsiveness. However, the use of ErbB2 t | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $660,770 | Grant | Trans-NIH Recovery Act Research Support: This application fits the broad Challenge Area (01): Behavior, Behavior Change, and Prevention (01); and specific Challenge Topic 01-CA-103: The role of health behaviors in cancer prevention. Skin cancer incidence is rising more rapidly than any other can | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| NEW YORK UNIVERSITY (INC) | $999,998 | Grant | Trans-NIH Recovery Act Research Support: Lymphoid neoplasms are among the most common malignancies in humans, and, for reasons that remain obscure, their incidence has been increasing over the past two decades. Although these disorders arise from diverse etiologies, chromosomal translocations in | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| NORTHSHORE UNIVERSITY HEALTHSYSTEM RESEARCH INSTITUTE | $705,133 | Grant | Trans-NIH Recovery Act Research Support: The research project plans to perform a comprehensive detection of fusion transcripts in acute myeloid leukemia, with the aims to identify new genes contributing to this disease and to identify new markers for clinical diagnosis, treatment and prognosis o | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| THE VANDERBILT UNIVERSITY | $997,012 | Grant | Trans-NIH Recovery Act Research Support: Lung cancer is the leading cause of cancer related deaths in the United States. Despite similar risk factors, African-Americans have higher incidence and mortality rates from lung cancer than other populations. Numerous studies have recently demonstrated | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | $673,179 | Grant | Trans-NIH Recovery Act Research Support: This study proposes to compare surgical treatment options for localized prostate cancer (MRP vs ORP) in terms of perioperative outcomes and cost, using several large national data resources and prospectively collected data from a large-volume specialty ca | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $998,275 | Grant | Trans-NIH Recovery Act Research Support: This Challenge Application is directly and completely responsive to Specific Challenge Topic: 03-CA-102 ?Biologic Predictors of Progression in Barrett?s Esophagus?. It comes from a research team with more than two decades of experience investigating Barre | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $787,758 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (05): Comparative Effectiveness Research and Specific Challenge Topic 05-CA-102: Comparative Effectiveness Research on Cancer Screening. Colorectal cancer (CRC) is the fourth most common cancer and the secon | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $926,262 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (01) Behavior, Behavioral Change, and Prevention and specific Challenge Topic, 01-AA-103: Capturing Social Network Information for Groups at High Risk for Negative Health Behaviors. NIH has identified the In | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF WASHINGTON | $952,757 | Grant | Trans-NIH Recovery Act Research Support: This application addresses two broad Challenge Areas, (05) Comparative Effectiveness Research and (09) Health Disparities, and specific Challenge Topics, 05-MD-102 Prevention of Chronic Diseases in Disparity Populations , and 09-DA-101 Health disparities | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $999,881 | Grant | Trans-NIH Recovery Act Research Support: This application addresses the broad Challenge Area (01) Behavior, Behavioral Change, and Prevention and the specific Challenge Topic, 01-DA-106: Development of behavioral and social interventions that reduce stigma and improve quality and accessibility o | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $944,347 | Grant | Trans-NIH Recovery Act Research Support: This application addresses Challenge Area (01) Behavior, Behavioral Change, and Prevention and specific Challenge Topic, 01-DA-104: Functional Roles of Glia-Derived Factors in Mediating Drug Abuse. In line with NIDA's mission to support research that will | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| MARINE BIOLOGICAL LABORATORY, THE | $951,296 | Grant | Trans-NIH Recovery Act Research Support: The human mouth is colonized by a microbial community of enormous complexity that plays a key role in human health and disease. Dental plaque is a biofilm constructed and inhabited by microbes, and the oral microbial community is involved in the developme | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $932,551 | Grant | Trans-NIH Recovery Act Research Support: Orofacial clefts, specifically cleft lip and cleft palate, are common and costly congenital anomalies whose etiologies remain largely unknown. One of the most promising clues to the causes of orofacial clefts is that women who use vitamins containing fol | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: This is a Challenge application submitted in response to an RFP in the ARRA. We proposed to do transformative genome-wide studies of relating circadian transcription factor binding to biological rhythms and metabolic pathways. | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $994,907 | Grant | Trans-NIH Recovery Act Research Support: The ultimate goal of the work proposed is to develop a stepwise protocol for the differentiation of human iPS cells into renal progenitor cells. A distinct population of renal progenitor cells could serve as a starting point for subsequent differentiation | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| THE VANDERBILT UNIVERSITY | $738,424 | Grant | Trans-NIH Recovery Act Research Support: The primary focus of this Challenge Proposal is to identify the signaling pathways that control regulatory processes of neural crest (NC) migration and differentiation which generate the neural elements of the lower urinary tract (LUT). There is a signifi | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY | $582,999 | Grant | Trans-NIH Recovery Act Research Support: This application addresses the broad Challenge Area (06) Enabling Technologies and the specific Challenge Topic, 06-GM-105: Small RNAs. Nearly 60% of the US adult population is either obese or overweight. Clearly understanding the fundamental mechanisms o | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $982,032 | Grant | Trans-NIH Recovery Act Research Support: Autosomal recessive cystic kidney diseases are rare genetic disorders that produce kidney failure in children. No specific treatment currently exists. This proposal will test the feasibility of treating these disorders using a new technology, microRNA-bas | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| EMORY UNIVERSITY | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (04) Clinical Research and specific Challenge Topic, 04-HD- 102: Development of Pediatric Medical Devices. The title of this project is G?Kidney Injury and Dysfunction Support (KIDS) - Development of a safe, | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $997,981 | Grant | Trans-NIH Recovery Act Research Support: In this study, we propose to perform the first genome-wide association study (GWAS) for Immunoglobulin A Nephropathy (IgAN, OMIM %161950), an understudied disease that is a major cause of kidney failure in the U.S. and worldwide. It is the most common cau | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF WASHINGTON | $998,611 | Grant | Trans-NIH Recovery Act Research Support: Determination between benign and malignant strictures in the bile ducts is difficult. Although non-invasive imaging modalities can locate the stricture, a definitive diagnosis cannot be made without an optical measurement of cells and tissue as no biomar | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| GEORGIA TECH RESEARCH CORPORATION | $998,645 | Grant | Trans-NIH Recovery Act Research Support: Developing and validating assistive neuro-technologies: 06-NS-104 Abstract/summary: Development and Translational Assessment of a Tongue-Based Assistive Neuro-Technology (ANT) for Individuals with Severe Neurological Disorders. More than two million Ameri | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE | $997,031 | Grant | Trans-NIH Recovery Act Research Support: This project addresses broad Challenge Area (15) Translational Science and specific Challenge Topic, 15-ES-101: Effects of environmental exposures on phenotypic outcomes using non-human models. Since the 1970's, adverse health effects have been reported | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $995,883 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (12) Science, Technology, Engineering, and Mathematics Education (STEM) and specific Challenge Topic 12-ES-101: Material Development for Environmental Health Curriculum. K-12 students share the public's conc | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $971,845 | Grant | Trans-NIH Recovery Act Research Support: ARRA - Computational and Cell Culture Models for Mucus Clearance The lung inhales over 1 million infectious and toxic agents each day. The defense of the lung begins with the layer of mucus that lines the epithelial cell layer. When these assaults land at | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| KAISER FOUNDATION HOSPITALS | $999,852 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (04) Clinical Research and specific Challenge Topic, 04-HL- 105: Treatment of Heart Failure with Preserved Systolic Function Multiple advances in pharmacological and device therapies have been made to improv | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF CHICAGO, THE | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: This proposal responds to the broad challenge area (04): Clinical Research and specific challenge topic 04-HL-102: Develop Integrative Strategies to Elucidate the Mechanisms of Lung Diseases. Pulmonary arterial hypertension (PAH) is a syndrome characteriz | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF MASSACHUSETTS | $985,004 | Grant | Trans-NIH Recovery Act Research Support: This application addresses the broad Challenge Area (01) Behavior, Behavioral Change, and Prevention and specific Challenge Area 01-HL-101: Develop innovative technologies and measurements to assess and provide real-time feedback on behavioral and environ | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| DUKE UNIVERSITY | $916,670 | Grant | Trans-NIH Recovery Act Research Support: The Broad Challenge Area addressed in this proposal is (03) Biomarker Discovery and Validation, and the Specific Challenge Topic is 03-HL-101. The purpose of this proposal is to improve the accurate and early diagnosis of idiopathic interstitial lung pneu | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| THE VANDERBILT UNIVERSITY | $949,776 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (03) Biomarker Discovery and Validation and specific Challenge Topic, 03-HL-101: Identify and Validate Clinically Relevant, Quantifiable Biomarkers of Diagnostic and Therapeutic Responses for Blood, Vascular | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF CHICAGO, THE | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (04) Clinical Research and specific Challenge Topic, 04-HL-101: Identify Mechanisms Linking Cardiopulmonary Disease Risk and Sleep-Disordered Breathing. Diabetes is increasing in epidemic proportions in the | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $972,594 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (11): Regenerative Medicine and specific Challenge Topic, 11-HL-101: Develop cell-based therapies for cardiovascular, lung, and blood diseases. Sudden cardiac death (SCD) due to myocardial infarction (MI) is | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER | $999,922 | Grant | Trans-NIH Recovery Act Research Support: This application is in response to RFA-OD-09-003 and addresses broad Challenge Area (15) Translational Science and specific Challenge Topic, 15-OD(ORDR)-101: Pilot Projects for Prevention, Early Detection, and Treatment of Rare Diseases. The congenital l | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| BAYLOR COLLEGE OF MEDICINE | $614,000 | Grant | Trans-NIH Recovery Act Research Support: Congenital Myotonic Dystrophy 1 (DM1) causes a delay of development in newborn children. There is no cure for this devastating multisystemic, neuro-muscular disease. This project will address the molecular mechanisms delaying development of muscle in pati | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $756,042 | Grant | Trans-NIH Recovery Act Research Support: Toward Tissue Engineering of the Knee Meniscus. This proposal seeks to tissue engineer allogeneic and xenogeneic anisotropic meniscus constructs that also capture the regional variations present in the native tissue. The aims of the proposal are 1) to cre | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $751,120 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this project is to characterize antigen loading and presentation by MHC and MHC-lik.e molecules primarily through three-dimensional structure determination using x-ray crystallography. The innate and adaptive immune systems playa funda | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $925,421 | Grant | Trans-NIH Recovery Act Research Support: The Role of Oderant Binding Proteins in Anopheline Mosquito Odor Perception The work proposed here will investigate the specificity of odorant recognition in the malaria mosquito, Anopheles gambiae, and correlate specific odor stimuli with quantifiable ph | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| BROWN UNIVERSITY IN PROVIDENCE IN STATE OF RI AND PROVIDENCE PLANTATIONS | $1,530,672 | Grant | Trans-NIH Recovery Act Research Support: The long term goals of this research are (1) to understand how cortical networks represent and transform plans into voluntary movement and (2) to use knowledge of cortical representation and processing for movement to develop neural prosthesis systems tha | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| VETERANS MEDICAL RESEARCH FOUNDATION OF SAN DIEGO | $1,247,552 | Grant | Trans-NIH Recovery Act Research Support: Alcoholism (alcohol abuse and dependence) is a common disorder with a peak age of onset in early adulthood and a complex etiology. Twin studies comprised predominantly of participants of European Caucasian ancestry have shown genetic factors contribute 40 | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $1,001,887 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to develop software that simplifies the analysis of brain imagedata. We will make all of these software components available from a web accessibleimage database. We expect that, as we implement more components of this softwares | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| WASHINGTON UNIVERSITY, THE | $1,132,490 | Grant | Trans-NIH Recovery Act Research Support: Alzheimer's disease (AD) is the most common neurodegenerative disease in the US, affecting over 4 million people over the age of 65 years. As the population of the world ages the number of people suffering from AD will increase rapidly during the coming | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| UNIVERSITY OF CINCINNATI | $706,500 | Grant | Trans-NIH Recovery Act Research Support: Pertussis toxin (PTX) is a complex AB5 toxin, comprised of the enzymatically active, 'A' subunit (S1), and the binding, 'B' oligomer (PTX-B), composed of five subunits S2, S3, S4, and S5, found in a 1:1:2:1 ratio. The B portions of AB toxins transport the | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $1,748,002 | Grant | Trans-NIH Recovery Act Research Support: Asthma is the most common disease of childhood in the United States. The role of microbial flora and allergens in asthma development is poorly understood. We found reduced pro-inflammatory Th2 cytokine production at age 2, reduced risk of eczema, and subs | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $762,750 | Grant | Trans-NIH Recovery Act Research Support: Influenza virus causes a respiratory infection that leads to morbidity and mortality worldwide. The virus infects the respiratory epithelium and replicates rapidly to peak levels in two days. It is eventually cleared from the lungs by a strong cellular im | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $768,939 | Grant | Trans-NIH Recovery Act Research Support: Cholera is a severe epidemic diarrheal disease caused by the gram-negative aquatic bacterium Vibrio cholerae. As is true for most bacterial pathogens, attachment to biotic surfaces such as the exoskeletae of copepods and the intestinal epithelium is criti | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF KENTUCKY | $749,365 | Grant | Trans-NIH Recovery Act Research Support: Natural killer (NK) cells kill infected and malignant cells and direct subsequent adaptive immunity. NK cells distinguish normal from aberrant cells largely via killer cell immunoglobulin-like receptors (KIR). Despite high homology between KIR genes, indi | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| TORREY PINES INSTITUTE FOR MOLECULAR STUDIES, INC. | $900,000 | Grant | Trans-NIH Recovery Act Research Support: Some viruses are able to persist in a latent or inactive form in normal healthy individuals, but can reactivate causing a range of diseases, including cancer, in immunocompromised individuals such as AIDS patients or transplant recipients, who lack effect | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| THE CHILDRENS HOSPITAL LOS ANGELES | $0 | Grant | Trans-NIH Recovery Act Research Support: The use of pigs as organ donors for human transplantation represents a solution to the escalating shortage of organs that are available for patients with end-stage diseases. Wild type pig organs are hyperacutely rejected, however, by pre-existing natural | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $899,156 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this proposal is to delineate the role of NF-(B subunits in the development of inflammatory bowel disease. NF-(B is a transcription factor family consisting of 5 subunits. Activation of NF-(B in response to Toll-like receptor (TLR) signalin | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF NEW MEXICO | $740,000 | Grant | Trans-NIH Recovery Act Research Support: Schistosome parasites cause infectious disease in over 200 million humans globally; some 600 million more are at risk of infection. This disease affects development in children, reduces general health and may ultimately lead to death. The parasites are tr | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $605,659 | Grant | Trans-NIH Recovery Act Research Support: The p73 gene, a member of the p53 family, is controlled by two alternate promoters. When the upstream P1 promoter is used for p73 expression, several TAp73 isoforms are produced. When the P2 promoter in intron 3 is used for p73 expression, several ?Np73 | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| HEALTH RESEARCH, INC. | $663,881 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The long-term objective is to determine the role of respiratory tract cytochrome P450 (P450 or CYP) enzymes in target tissue metabolic activation and toxicity of environmental chemicals. Our focus continues to be on CY | Health and Human Services, Department of / National Institutes of Health | 8/12/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $673,878 | Grant | Trans-NIH Recovery Act Research Support: The broad long term objective of this proposal is to understand the pathogenesis of natural killer (NK) LGL leukemia. The mechanisms responsible for expansion of leukemic NK cells are not completely known. Leukemic NK cells are characterized by Fas-resist | Health and Human Services, Department of / National Institutes of Health | 6/19/2009 |
| UNIVERSITY OF CHICAGO, THE | $552,564 | Grant | Trans-NIH Recovery Act Research Support: Radiation Biology of EPR Oxygen Images Abstract: Electron Paramagnetic Resonance (EPR) Oxygen Images (EPROI) have been shown to provide quantitative localized pO2 images in FSa fibro sarcomas grown in the legs of C3H mice. The widths of narrow EPR spectra | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF FLORIDA | $429,719 | Grant | Trans-NIH Recovery Act Research Support: Cocaine abuse continues to be an important public-health concem. Because cocaine abuse is not an automatic consequence of cocaine use, it is important to study factors that may lead from the latter to the former. Two such factors that have been implicated | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $596,061 | Grant | Trans-NIH Recovery Act Research Support: The use of nicotine via cigarette smoking forms lifelong memories that are recalled in response to environmental cues associated with previous nicotine use. This recall increases nicotine craving and is a factor for the continued use of nicotine. Memory f | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF PITTSBURGH THE | $657,790 | Grant | Trans-NIH Recovery Act Research Support: Stress is a major factor in the onset and relapse to drug abuse. Over the past funding period, the effects of stress on the amygdala-locus coeruleus (LC) system, and how the response is altered after chronic stress exposure, was examined. In this resubmi | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| DUKE UNIVERSITY | $612,800 | Grant | Trans-NIH Recovery Act Research Support: Our long-term goal is to understand the organization of the brainstem auditory pathways in terms of connections among the multiple neuronal types that form them. The objective of the proposed studies is an analysis of the origins and terminations of speci | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $783,008 | Grant | Trans-NIH Recovery Act Research Support: Neuron loss, either dependent or independent of sensory hair cell loss, contributes significantly to hearing loss, particularly in the aging population. Future treatments, particularly stem cell therapies, will require detailed understanding of statoacous | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| UNIVERSITY OF PITTSBURGH THE | $909,000 | Grant | Trans-NIH Recovery Act Research Support: Incomplete healing of bone defects in the craniofacial skeleton is common. Osteogenic proteins, including bone morphogenetic protein 2 and 4 (BMP2, BMP4), promote healing in bone defects, but the proteins' short half-lives and rapid clearance by the blood | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $706,500 | Grant | Trans-NIH Recovery Act Research Support: Vitamin D receptor coactivators in bone. 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) is the bioactive hormone of the vitamin D endocrine system. It functions via the vitamin D receptor (VDR) to impact bone by increasing intestinal calcium absorption and by di | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $903,136 | Grant | Trans-NIH Recovery Act Research Support: Hepatitis C virus (HCV) is a major health problem affecting approximately 200 million throughout the world. Although new therapies have improved the rates of sustained response, a large proportion of patients (~50%) fail to respond to antiviral treatment | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| THE VANDERBILT UNIVERSITY | $842,808 | Grant | Trans-NIH Recovery Act Research Support: The goal of this research proposal is to understand the role of primate primary visual cortex (V1) and second visual cortical area (V2) in the processing of visual depth information. In the previous funding cycles, we investigated the organization of cont | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| DUKE UNIVERSITY | $780,000 | Grant | Trans-NIH Recovery Act Research Support: Development and function of the ocular lens depends on controlled proliferation of epithelial cells, and on migration, elongation, adhesion, and cytoarchitecture of the resulting fiber cells. Neither the identity of the molecular mechanisms that regulate | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER | $753,060 | Grant | Trans-NIH Recovery Act Research Support: Nanophthalmos is a rare genetic disorder in which both eyes are well formed, but have unusually short axial lengths. Extreme hyperopia, from +8 to +25 diopters, occurs because the image-forming cornea and lens are too close to the retina. As adults, nanop | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| WAYNE STATE UNIVERSITY (INC) | $738,034 | Grant | Trans-NIH Recovery Act Research Support: This proposal is aimed at understanding the putative regulatory role(s) of matrix metalloproteinases in glucose-induced alterations in metabolic functions of retinal capillary cells leading to their demise, and the development of diabetic retinopathy. The | Health and Human Services, Department of / National Institutes of Health | 9/02/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $770,000 | Grant | Trans-NIH Recovery Act Research Support: Cataracts affect an estimated 20.5 million Americans, expected to rise to 30.1 million by 2020. Removal of cataracts and treatment for the most common complication of this procedure, posterior capsule opacification (PCO), are major Medicare expenditures. | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| UNIVERSITY OF ARKANSAS SYSTEM | $585,310 | Grant | Trans-NIH Recovery Act Research Support: The long range goals of our research program are to develop and apply new techniques to study biological electron transfer reactions. These reactions play essential roles in numerous biological processes important to human health, including oxidative pho | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| UNIVERSITY OF NOTRE DAME DU LAC | $600,000 | Grant | Trans-NIH Recovery Act Research Support: This project will study fundamental properties of hemes derivatives, especially those with the gaseous ligands NO, O2, CO, and H2S. We are studying the dynamics of iron in these derivatives that will provide essential information on how the components of | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF PITTSBURGH THE | $627,830 | Grant | Trans-NIH Recovery Act Research Support: Ready access to seven-membered rings systems will facilitate the synthesis of biologically important compounds possessing this ring system. Three carbocyclic cores of three targets, thapsigargin, grayanotoxin III and guanacastepene J, will be synthesiz | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $608,679 | Grant | Trans-NIH Recovery Act Research Support: The degradation of proteins within cells controls multiple cellular processes. Protein degradation is used to control the division of cells, and defects in degrading cell cycle regulatory proteins can lead to cancer. Many cellular proteins are degraded | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $586,872 | Grant | Trans-NIH Recovery Act Research Support: Linear chromosomes terminate in specialized nucleoprotein structures called telomeres, which are required for genomic stability and cellular proliferation. Telomeres end in an unusual GT-rich 32 single-strand overhang that requires a special cap to preven | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $690,446 | Grant | Trans-NIH Recovery Act Research Support: One of the most challenging problems in molecular design is developing molecules that can bind protein surfaces and block protein-protein interactions. The ability to modulate protein-protein interactions in a directed fashion opens the possibility of pro | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF UTAH, THE | $511,417 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This proposal builds on previous research that developed the dog as a model for the genetic analysis of complex traits. A working relationship with owners and breeders of Portuguese Water dogs (PW dogs) has led to a da | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| BAYLOR COLLEGE OF MEDICINE | $676,735 | Grant | Trans-NIH Recovery Act Research Support: The long-term objective of this application is to elucidate the molecular mechanisms underlying TGF+? regulation and functions, and understand the molecular basis of how alterations in TGF+? responses lead to deregulation of growth control in human cancer | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| GEORGIA TECH RESEARCH CORPORATION | $532,292 | Grant | Trans-NIH Recovery Act Research Support: The long-term project goal is to create small, highly fluorescent, and optically modulatable nanomaterials to enable a whole new array of high sensitivity imaging and detection capabilities in extremely high background biological environments. Beautifully | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| UNIVERSITY OF WASHINGTON | $786,993 | Grant | Trans-NIH Recovery Act Research Support: Warfarin is the most widely-used oral anticoagulant in the world, but therapy is difficult to manage because of wide inter-individual variability in response to the drug, a low therapeutic index, and the resulting serious (sometimes fatal) consequences of | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| NORTHWESTERN UNIVERSITY | $762,500 | Grant | Trans-NIH Recovery Act Research Support: The long-term objective of this application is to better understand the phenomenon of progesterone resistance in endometriosis in order to develop alternate therapies for this disease. The action of progesterone receptor (PR) in the physiological context | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $832,418 | Grant | Trans-NIH Recovery Act Research Support: Recovery Act funds have been awarded for the study of 'Effects of sex and fat distribution on sleep disordered breathing'. This award will support two additional senior faculty members (total of 25% effort ), two new junior faculty (30% effort) and techni | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF CALIFORNIA, SANTA BARBARA | $715,880 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): We hypothesize that small fractions (1-5 wt%) of cholesterol reduce the crystalline ordering of saturated lipids in lung surfactant monolayers, leading to a reduction in the shear viscosity, which enhances the surfacta | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $755,000 | Grant | Trans-NIH Recovery Act Research Support: Natural killer (NK) cells develop from primitive hematopoetic stem cells into functional anti-tumor effector cells that express receptors recognizing MHC class I ligands. In addition to the killer immunoglobulin-like receptor (KIR) family, NKG2A and LIR-1 | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| BAYLOR COLLEGE OF MEDICINE | $1,176,035 | Grant | Trans-NIH Recovery Act Research Support: Our plan is to develop a new therapy for heart disease. Abstract: Cardiovascular disease is a major cause of mortality and morbidity and development of therapies that address its underlying causes is an important public health priority. With better ma | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF ILLINOIS | $916,323 | Grant | Trans-NIH Recovery Act Research Support: We have shown in the fetus and newborn, that in pulmonary vascular relaxation induced by cGMP-elevating agents, cGMP-dependent Protein Kinase (PKG) plays a primary role. We have also reported that hypoxia attenuates nitric oxide-cGMP-mediated relaxation b | Health and Human Services, Department of / National Institutes of Health | 5/30/2009 |
| UNIVERSITY OF NOTRE DAME DU LAC | $750,000 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this proposal is to identify functions and determine mechanisms of the fibrinolytic system, and its inhibitors, in physiological and pathological processes utilizing cell based and in vivo models. The availability of mice with defici | Health and Human Services, Department of / National Institutes of Health | 6/15/2009 |
| EMORY UNIVERSITY | $967,294 | Grant | Trans-NIH Recovery Act Research Support: Inhibitory antibodies to factor VIII develop in approximately 30% of patients with severe and moderately severe hemophilia A in response to infusions of factor VIII. Inhibitor development is associated with a lower quality of life and an increased economi | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| THE VANDERBILT UNIVERSITY | $2,391,446 | Grant | Trans-NIH Recovery Act Research Support: Multiple sclerosis (MS) is a debilitating neuroimmunological and neurodegenerative disorder affecting more than 400,000 individuals in the United States. Epidemiological and genetic studies have produced overwhelming evidence for a genetic influence on th | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | $1,067,230 | Grant | Trans-NIH Recovery Act Research Support: Abnormal accumulation and deposition of the amyloid ss-protein (Ass), a prominent pathological feature of patients with Alzheimer's disease (AD) and related disorders, can occur from increased production but in most cases is likely due to decreased cleara | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $1,054,834 | Grant | Trans-NIH Recovery Act Research Support: The suprachiasmatic nucleus (SCN) is the master circadian clock in mammals. Individual SCN neurons are cell-autonomous oscillators with diverse free-running periods of activity (19 to 28 hours). Intracellular communication is required to synchronize these | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $1,216,058 | Grant | Trans-NIH Recovery Act Research Support: This project involves the identification of genes in mice that determine their susceptibility to experimentally induced seizures. Whereas the short term goal of the project involves the identification of seizure susceptibility genes, the longer term goal | Health and Human Services, Department of / National Institutes of Health | 9/20/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $1,016,847 | Grant | Trans-NIH Recovery Act Research Support: Secretion is one of the most ubiquitous of cellular processes. Indeed, it is central to such diverse biological functions as information processing, reproduction, motility, temperature regulation, metabolism, the immune response, and signal transduction. | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF PITTSBURGH THE | $441,615 | Grant | Trans-NIH Recovery Act Research Support: Aim 1: To test the hypothesis that a-Syn inhibits TH in vivo by effects on PP2A. Our in vitro data suggest that a-Syn inhibits TH and reduces DA synthesis, by increasing PP2A activity. To assess this in vivo, we will use nigral and striatal tissue from | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $892,864 | Grant | Trans-NIH Recovery Act Research Support: Notch signaling in mammalian neural progenitors, this work will contribute to the treatment of nervous system disorders, including brain cancer and neurodegenerative diseases, and to the treatment of traumatic brain injury. | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| NEW YORK UNIVERSITY | $747,958 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of the proposed work in this application is to identify the biochemical mechanisms responsible for initiating protein synthesis during synaptic plasticity and memory, and whether these mechanisms are altered and can be reversed in mouse m | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $800,968 | Grant | Trans-NIH Recovery Act Research Support: Since its introduction over a decade ago, functional magnetic resonance imaging (fMRI) has revolutionized studies of the working human brain. While most fMRI studies measure the blood oxygenation level dependent (BOLD) response to a functional task, there | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| SALK INSTITUTE FOR BLOGICAL STUDIES | $1,050,892 | Grant | Trans-NIH Recovery Act Research Support: The principles of immune system function are derivable from a consideration of its evolutionary origins. The rate of germline evolution of pathogens is vastly more rapid than that of their vertebrate hosts. The solution used by evolution was to couple a s | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| MISSOURI SYSTEM, UNIVERSITY OF | $225,750 | Grant | Trans-NIH Recovery Act Research Support: The importance and need for continuous metabolites monitoring cannot be overemphasized. Most recent developments for in vivo monitoring devices have focused on miniaturization and the exploratory use of new functional materials. As most biosensors tend to | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| PHARMAREVIEW CORPORATION | $2,977,916 | Grant | Trans-NIH Recovery Act Research Support: The Specific Aims of the proposal is modified to reflect a change in scope, according to recommendations from the review panel. The aims of this Phase II continuation proposal are to utilize fully humanized recombinant lactoferrin (rhLF) as an adjuvant | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| INTERTHYR CORPORATION | $2,652,865 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Interthyr Corporation (IC) is requesting an Advanced Technology Phase II STTR award to develop a novel agent with a new therapeutic paradigm: Inhibition of Toll-like receptor (TLR) expression and signaling in non-immun | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| ACIONT INC | $2,171,045 | Grant | Trans-NIH Recovery Act Research Support: The overarching aim of this innovative proposal is to develop and then commercialize a non-invasive topical product which is safe and easy to administer that treats severe uveitis, including intermediate and posterior uveitis. Uveitis is the third leading | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| NEW YORK UNIVERSITY (INC) | $820,677 | Grant | Trans-NIH Recovery Act Research Support: This project is about regulatory T cells, which are essential components of the immune system. Through experiments conducted during the previous funding cycle we observed that in the presence of Tregs, antigen-presenting dendritic cells (DCs) are recovere | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF LOUISVILLE | $50,000 | Grant | Trans-NIH Recovery Act Research Support: This award will be used for salary and benefits to support one post-doctoral fellow. Since the award of this supplement application was notified on 09/14/2009, the post-doctoral fellow has been hired to carry out experiments proposed in the supplement ap | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| YALE UNIVERSITY | $108,000 | Grant | Trans-NIH Recovery Act Research Support: Dr. Simen is a clinical psychiatrist with a Ph.D. degree in Neurobiology. His career goals are to become an independent investigator in the Aging field, with a focus on how genomic changes that occur with age influence risk for cognitive and behavioral di | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF NEBRASKA | $106,660 | Grant | Trans-NIH Recovery Act Research Support: Organic dust exposure is an important occupational hazard for persons who work in swine confinement barns. Organic dust exposure to naive individuals results in an intense systemic and pulmonary inflammatory response that attenuates over time, suggestive | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $166,240 | Grant | Trans-NIH Recovery Act Research Support: Posterior polymorphous corneal dystrophy (PPCD, MIM #122000) is a dominantly inherited corneal endothelial dystrophy associated with a varied phenotype, ranging from symptomatic corneal endothelial changes to glaucoma and progressive corneal edema causing | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $179,804 | Grant | Trans-NIH Recovery Act Research Support: The Center for Health Improvement of Minority Elderly This purpose of this administrative supplement request from the Resource Centers for Minority Aging Research (RCMAR) National Coordinating Center at UCLA (CC) is to provide funding to minority scholar | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| YALE UNIVERSITY | $31,445 | Grant | Trans-NIH Recovery Act Research Support: Data from our laboratory has shown that gamma-amino butyric acid (GABA) inhibitory tone within a crucial glucose sensing region of the brain, the ventromedial hypothalamus (VMH), plays an important role in modulating the magnitude of glucose counter regul | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $696,196 | Grant | Trans-NIH Recovery Act Research Support: Support to provide shared resources for research activities at the Jules Stein Eye Institute at the University of California, Los Angeles. | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $280,527 | Grant | Trans-NIH Recovery Act Research Support: CENTER FOR NEUROVISCERAL SCIENCES & WOMEN'S HEALTH The Center for Neurovisceral Sciences & Women's Health is composed of a cohesive group of clinical investigators and basic scientists with strong independent grant-supported research programs in the inte | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| CORNELL UNIVERSITY, INC | $84,177 | Grant | Trans-NIH Recovery Act Research Support: We requested an administrative supplement to purchase (1) an HPLC system with supporting computers and columns and (2) a high pressure cell homogenizer to augment the work supported by R01GM062328. The award is final and the equipment was purchased at a l | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| YALE UNIVERSITY | $53,421 | Grant | Trans-NIH Recovery Act Research Support: Continued support is requested for our investigation of integrin-filamin interactions and their roles in adhesion signaling and cell migration. Integrins are transmembrane receptors that support cell adhesion and migration. They play essential roles throu | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF OKLAHOMA | $999,998 | Grant | Trans-NIH Recovery Act Research Support: Vision loss caused by macular degeneration (AMD) is the leading cause of blindness in developed countries. This disease involves loss of RPE, death of photoreceptors, and subretinal neovascularization. Similar pathological manifestations have been appre | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| UNIVERSITY OF KENTUCKY | $1,451,533 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement request addresses the 'Advance Translational (T1 & T2) Research' solicitation of the NCRR within the ARRA program. The project proposed for support under an administrative supplement for the CSSO/SD will implement an interve | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF WASHINGTON | $43,659 | Grant | Trans-NIH Recovery Act Research Support: The University of Washington Nathan Shock Center of Excellence in the Basic Biology of Aging provides infrastructure and resource support to the large number of NIA-funded investigators at the University of Washington and affiliated Seattle institutions. | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $252,000 | Grant | Trans-NIH Recovery Act Research Support: The proposed project will quantify methods to educate Black elders and their families about clinical research and brain donation program participation to develop and implement an educational protocol to increase research participation and donation complia | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| THE MIRIAM HOSPITAL | $77,950 | Grant | Trans-NIH Recovery Act Research Support: This grant provided research experiences for five (5) undergraduate students in health-related scientific research. The overall goal of this supplement was to provide enriching scientific experiences for local undergraduate students. Given the breadth a | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $50,000 | Grant | Trans-NIH Recovery Act Research Support: This project is to participate in the planning activities associated with the project entitled ADOPTion of New Technologies for Remote Data Capture and Protocol Authoring (ADOPT) by providing appropriate clinical and informatics expertise in scheduled mee | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $50,008 | Grant | Trans-NIH Recovery Act Research Support: We have, according to the requirements of the ADOPT supplement, participated in all meetings and conference calls to date. No meetings were scheduled, but two conference calls were scheduled. We attended the first conference call, and the second confere | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |