Listing all stimulus spending by amount, in descending order. Return to National Institutes of Health page
Amount refers to both the amount of stimulus funding going toward the project and the face value of the loan.
| Recipient | Amount | Type | Description | Federal Dept./Agency | Date |
|---|---|---|---|---|---|
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO ,THE | $531,248 | Grant | Trans-NIH Recovery Act Research Support: Please Note: This award was requested to be relinquished by The University of Texas Health Science Center at San Antonio back to NIH as of 08/01/09. | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $803,542 | Grant | Trans-NIH Recovery Act Research Support: Opioid abuse and dependence continues to be a significant problem in the US; in particular, rates of non-medical use of prescription opioids have increased in the past several years. The main treatment approaches include detoxification followed by psychos | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF UTAH, THE | $1,376,400 | Grant | Trans-NIH Recovery Act Research Support: This research addresses the need for innovative bioreactor design. Bioreactors are laboratory systems that precisely control mechanical forces and environmental conditions on biologically changing tissues for periods of several hours to many days. Some bi | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| FORSYTH DENTAL INFIRMARY FOR CHILDREN | $1,142,778 | Grant | Trans-NIH Recovery Act Research Support: The prevalence of fluorosis among the population is increasing yet we currently know very little about what causes fluorosis. We have previously demonstrated that fluoride elicits a cell stress response which in turn, activates genes to help the cell cope | Health and Human Services, Department of / National Institutes of Health | 4/29/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $787,075 | Grant | Trans-NIH Recovery Act Research Support: Using live animal imaging, we have revealed that the bacterial pathogen Listeria grows inside the gallbladder. This bacterium normally replicates within cells, which permits it to invade many tissues, causing life threatening disease especially in the ver | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $675,660 | Grant | Trans-NIH Recovery Act Research Support: The pancreas secretes digestive enzymes and fluid that contains a lot of HCO3 that wash the enzymes to theintestine. The HCO3 is needed to prevent premature activation of the e | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $1,522,341 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this proposal is to understand the contribution of metabolic, behavioral and diabetes-specific risk factors to the development of cardiovascular sub-clinical abnormalities in adolescents and young adults with T1D, as compared to non-di | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $693,000 | Grant | Trans-NIH Recovery Act Research Support: Obesity is a risk factor for the development of cardiovascular disease, diabetes, and cancer. The emerging role of angiogenesis in regulating growth of adipose tissue is a subject of great interest and investigation. We have reported that Hepatocyte Growt | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $755,000 | Grant | Trans-NIH Recovery Act Research Support: Existence of powerful nuclear reprogramming activities in egg cytoplasm has been unequivocally demonstrated by successful somatic cell nuclear cloning using terminally differentiated cell nuclei as donors. These reprogramming activities can induce dediffe | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $1,064,142 | Grant | Trans-NIH Recovery Act Research Support: The proposed program of research will address conservative therapies for OAB and urge incontinence in men. We will plan a 2-stage, randomized clinical trial to examine the effectiveness of behavioral treatment, drug therapy, and combined behavioral and dr | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $744,060 | Grant | Trans-NIH Recovery Act Research Support: Hirschsprung disease, or aganglionic megacolon, is a congenital defect that affects 1 out of 5,000 live births and is characterized by a failure to form enteric nervous system (ENS) in a variable length of the hindgut. This potentially fatal condition res | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $1,473,757 | Grant | Trans-NIH Recovery Act Research Support: The specific aims of this Phase 1 of a 2-Phase program to design, manufacture, and operate a prototype 200MHz/38mm 'bench-top' NMR 'annulus' magnet (in Phase 2: 300MHz/43mm and 500MHz/43mm magnets) are four-fold: 1) Design, manufacture, and operation of a | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $744,567 | Grant | Trans-NIH Recovery Act Research Support: A barrier to the effective delivery of cancer chemotherapy drugs is the transport of the toxic drug to specific tumor cells, ensuring high uptake of drug by cancer cells while avoiding noncancerous ones. One means of accomplishing this method is the use o | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $710,570 | Grant | Trans-NIH Recovery Act Research Support: Different electric and magnetic field (E/MF) configurations have been applied for non-invasive imaging therapies and surgery (laser) for many years. Unlike their higher energy counterparts, the biological mechanisms underlying the effects of exposure to l | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| GENERAL ELECTRIC COMPANY | $1,848,540 | Grant | Trans-NIH Recovery Act Research Support: Development of wearable sensors for point-of-contact, near-real time monitoring of exposure to enviromental chemical species is critical to the success of studies of diverse populations. The demand for these sensors is driven by the yet unmet need for wea | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| FORSYTH DENTAL INFIRMARY FOR CHILDREN | $99,997 | Grant | Trans-NIH Recovery Act Research Support: Over the past few years several important oral pathogens have been fully or partially sequenced. These genetic sequences hold a tremendous amount of biological information and valuable data to be explored and analyzed. Microarray is one of the best techno | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| PALO ALTO INSTITUTE FOR RESEARCH AND EDUCATION, INC. | $11,732 | Grant | Trans-NIH Recovery Act Research Support: Muscle wasting is common in advanced chronic kidney disease (CKD) and adversely affects morbidity and mortality. In 2/3 of males with advanced CKD serum testosterone (TT) levels are reduced, and likely contributes to the wasting. As TT in relatively saf | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| HUNTINGTON MEDICAL RESEARCH INSTITUTES | $37,453 | Grant | Trans-NIH Recovery Act Research Support: Development and evaluation of biodegradeable neural electrodes. Porvides summer research experience for two students in health related scientific research. The students will learn how to develop novel biodegradeable probe materials for enhancing record | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| ORDWAY RESEARCH INSTITUTE, INC. | $222,920 | Grant | Trans-NIH Recovery Act Research Support: Grant Title: Activating liver carcinogens in yeast by expressing CYP450 polymorphisms. Abstract: Exposure to carcinogens, including aflatoxin B1 (AFB1), benzo[a]pyrene (BaP), heterocyclic amines (HAs), poses a significant risk factor for liver, lung, and | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) | $38,000 | Grant | Trans-NIH Recovery Act Research Support: In the parent grant, we propose to develop a system where retinal neural circuits can be reproducibly designed on microelectronic arrays. Our project relies on optical tweezers, which we have used in a novel way to micromanipulate neurons isolated from ve | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $389,400 | Grant | Trans-NIH Recovery Act Research Support: Our research into the pathophysiology of presbyopia, the age-related loss of the eye's ability to focus on near objects, has found evidence in a monkey model that the aging ciliary muscle is restricted in accommodative movement by its posterior elastic a | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $23,787 | Grant | Trans-NIH Recovery Act Research Support: This award supported three college students to work in the laboratory over 11 weeks in the summer of 2009 and gain hands on experience at the bench so that they might consider a career in science. During their time in the laboratory, the students were g | Health and Human Services, Department of / National Institutes of Health | 6/19/2009 |
| PALO ALTO RESEARCH CENTER INCORPORATED | $179,948 | Grant | Trans-NIH Recovery Act Research Support: The broad, long-term objective of the proposed project is to enable mass spectrometry based protein research. The project will develop algorithms and software for peptide identification in difficult proteomics samples, including heavily modified samples, | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $60,753 | Grant | Trans-NIH Recovery Act Research Support: Children with special health care needs (CSHCN) make up 15% of all children and account for the majority of pediatric health expenditures. Parents of CSHCN experience greater work disruptions than other parents, largely due to episodic exacerbations of th | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $80,215 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Exploring the Import of Health-related Residential Mobility to Local Area Studies Description / Summary: Although most studies of place effects on health are ecological or multilevel analyses of cross-sectional data, f | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF PITTSBURGH THE | $90,764 | Grant | Trans-NIH Recovery Act Research Support: Trauma is the leading cause of death and disability in children. This project will design and test neuroprotective efficacy of mitochondria targeted antioxidants against neuronal death in TBI using state of art oxidative lipidomics and mass spectrometry i | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF TEXAS AT ARLINGTON | $25,166 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement will provide salary and benefit support for a new full-time graduate student to work on a part of our current funded research project, to develop novel nanoparticles, platelet-mimicking nanoparticles, as a drug carrier that | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $105,937 | Grant | Trans-NIH Recovery Act Research Support: Hopkins Digestive Diseases Basic Research Development Center (DDBRDC) services 30 Hopkins PIs and has as its goal improving the research in gastroenterology done at JHUSOM. Due to the success of this Core Center we are overwhelmed in use of our resources | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| UNIVERSITY OF WASHINGTON | $579,874 | Grant | Trans-NIH Recovery Act Research Support: CSDE's administrative supplement request is aimed at enhancing an emerging program of spatial demographic research at the University of Washington. Supplement funds will be used to promote more spatial demography research through the pilot project mechan | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| ALBERT EINSTEIN HEALTHCARE NETWORK | $230,798 | Grant | Trans-NIH Recovery Act Research Support: Administrative supplement for purposes of accelerating the tempo of research in several key areas as well as enhancing job creation and retention for investigators and support staff. | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | $596,678 | Grant | Trans-NIH Recovery Act Research Support: The administrative supplement aims to reduce Hepatitis B health disparities for medically underserved Korean Americans using CBPR approaches. Specifically, this supplement will enable us to strengthen and expand the community research infrastructure and c | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF MARYLAND | $225,202 | Grant | Trans-NIH Recovery Act Research Support: There is a documented need for palliative care training for practitioners of internal medicine and related subspecialties at the post-doctoral level. Our project's goal is to create palliative and end-of-life competency assessment tools to be used in dail | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| WAKE FOREST UNIVERSITY | $212,229 | Grant | Trans-NIH Recovery Act Research Support: Overweight and obesity are epidemic in the United States with over 2/3 of American adults having a body mass index of > 25 kg/m.2 Obesity and physical inactivity represent the second leading cause of preventable death nationally from cancer, cardiovascula | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| UNIVERSITY OF WASHINGTON | $70,092 | Grant | Trans-NIH Recovery Act Research Support: This R25, currently in Year 3, was designed to develop a novel facultydevelopment program that will improve the ability of faculty at cancercenters with fellowship programs to teach communication skills tooncology fellows. We have now completed 2 cohorts | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| CHARLES DREW UNIVERSITY OF MEDICINE AND SCIENCE | $138,240 | Grant | Trans-NIH Recovery Act Research Support: Charles R. Drew University of Medicine and Science (Drew) proposes to continue and enhance its Drew National High School Student Summer Research Apprentice Program (NHSSSRAP). The main goal is to increase the number of underrepresented minority and disadv | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| UNIVERSITY OF NEW MEXICO | $172,873 | Grant | Trans-NIH Recovery Act Research Support: This is a supplement to our IMSD grant, which funds student research. The supplement provides computers for a laboratory course and a flow cytometer that will be used in lab classes. We also will hire a graduate assistant to help with evaluation and stu | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| RFCUNY - BROOKLYN COLLEGE | $104,521 | Grant | Trans-NIH Recovery Act Research Support: For support to develop and/or implement a program as it relates to a category in one or more of the areas of education, information, training, technical assistance, coordination, or evaluation. | Health and Human Services, Department of / National Institutes of Health | 8/05/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $117,004 | Grant | Trans-NIH Recovery Act Research Support: The goals of Mount Sinai School of Medicine's Post-baccalaureate Research Education Program (PREP), for which renewed support is sought, are to: (i) increase enrollment of under-represented minority (URM) PhD and MD-PhD students in our own graduate progra | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| BROWN UNIVERSITY IN PROVIDENCE IN STATE OF RI AND PROVIDENCE PLANTATIONS | $161,464 | Grant | Trans-NIH Recovery Act Research Support: The IMSD Scholars Program in Brown University's Division of Biology and Medicine will significantly increase the number of underrepresented minority (URM) Ph.D. students trained for careers in basic biomedical and public health research. Efforts already i | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| MEHARRY MEDICAL COLLEGE | $593,718 | Grant | Trans-NIH Recovery Act Research Support: The Clinical Research and Education for Career Development (CRECD) award supplement will expand and enhance research development opportunities and mentoring for CRECD trained physician scientists at Meharry Medical College. | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $293,388 | Grant | Trans-NIH Recovery Act Research Support: Inbred miniature swine provide a unique preclinical model for the study of transplantation immunity and tolerance. We have previously demonstrated that robust tolerance to MHC class l-mismatched renal allografts can be achieved following a short course of | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $166,110 | Grant | Trans-NIH Recovery Act Research Support: Biological Properties of HIV-1 V3 Evolutionary Variants (ARRA) This ARRA funded grant is a supplement to the parent grant R37-AI44667 !Biological Properties of HIV-1 V3 Evolutionary Variants!. This funding is accomplishing two important goals relevant to | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| ROCKEFELLER UNIVERSITY FACULTY AND STUDENTS CLUB INC, THE | $256,474 | Grant | Trans-NIH Recovery Act Research Support: The global aim of the parent MERIT Award grant is to develop a molecular understanding of stem cell lineages and morphogenesis in mammalian skin and bring this research to a clinical setting. This important research centers around elucidating the mechanis | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF HAWAII SYSTEMS | $287,319 | Grant | Trans-NIH Recovery Act Research Support: The Multiethnic Cohort (MEC) Study was designed to prospectively investigate the relationship of diet an other lifestyle factors to cancer risk in five ethnic groups (African Americans, Japanese Americans, Latinos Native Hawaiians and Caucasians),and to e | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| NORTHWESTERN UNIVERSITY | $271,493 | Grant | Trans-NIH Recovery Act Research Support: A request for an administrative supplement under the American Recovery and Reinvestment Act of 2009 willl allow for hiring of a new personnel as well as retention of existing fellows. | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| UNIVERSITY OF CHICAGO, THE | $581,604 | Grant | Trans-NIH Recovery Act Research Support: Diseases and suffering caused by reactivations of latent Herpes Simplex Viruses (HSV) remain a major medical problem notwithstanding effective attenuation of disease by currently available antiviral drugs. The major problem facing development of specific | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $575,217 | Grant | Trans-NIH Recovery Act Research Support: Notice Number - NOT-OD-09-058 Notice Title: NIH Announces the Availability of Recovery Act Funds for Competitive Renewal Applications. Type 2 diabetes is characterized by impaired insulin action in tissues such as muscle, liver, and adipose tissue. Our lo | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $100,000 | Grant | Trans-NIH Recovery Act Research Support: The machinery responsible for making proteins (e.g. ribosomal RNA, ribosomal proteins, translation factors, and tRNAs) is central to growth and development of all organisms, and the control of its synthesis has been a central issue in molecular microbioog | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF ROCHESTER | $60,000 | Grant | Trans-NIH Recovery Act Research Support: The present Administrative Supplement will help purchase equipment and/or retain personnel to accelerate progress toward understanding the flexibility of neural circuits that control hand and finger movements. Understanding how neurons of the brain flexib | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| NORTHERN ILLINOIS UNIVERSITY INC | $105,260 | Grant | Trans-NIH Recovery Act Research Support: Epilepsy affects 1-2% of the population. Half of all new cases arise in infancy through early adolescence. Seizure outcomes are highly varied. Epilepsy can be a life-long intractable disorder or may resolve after only a few seizures. Many individuals, how | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| THERALOGICS,INC | $234,764 | Grant | Trans-NIH Recovery Act Research Support: This supplement proposal investigates a new compound that can block the white blood cells that cause Graft vs. Host Disease (GVHD) and the proteins that cause the symptoms associated with GVHD. Experiments are proposed in animal models to test the activi | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| SQUARE ONE SYSTEMS DESIGN, INC. | $143,172 | Grant | Trans-NIH Recovery Act Research Support: An Integrated Room Temperature Crystal Characterization System Square One Systems Design, Inc. Summary: The goal of Square One Systems Design?s STTR Phase II development effort is the creation of a flexible automated workcell-- the Universal Micromanipula | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| CLINICAL TOOLS, INC | $119,509 | Grant | Trans-NIH Recovery Act Research Support: This is a competitive revision application in response to NOT-OD-09-058 NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications. Medical schools provide little background and training to prepare future physicians to deal | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| AMERICAN LIFE SCIENCE PHARMACEUTICALS, INC. | $195,997 | Grant | Trans-NIH Recovery Act Research Support: Grant Title: Development of protease inhibitor drugs to treat Alzheimer's disease. The ARRA grant allows a postdoctoral hire to synthesize inhibitor drugs that may lead to potential Alzheimer's disease drugs. | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| CLEVELAND MEDICAL DEVICES INC. | $139,411 | Grant | Trans-NIH Recovery Act Research Support: The objective is to design, build, and clinically assess ParkinTune, an advanced wireless movement disorder technology to augment stimulation programming (tuning) involved in deep brain stimulation (DBS) procedures for Parkinson?s Disease (PD). Major PD s | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| AMBERGEN, INC | $399,000 | Grant | Trans-NIH Recovery Act Research Support: This overall parent project aims to develop a new, highly sensitive, mutation scanning technology for the molecular analysis of cancer. While broadly applicable in oncology, the initial commercial product which is the focus of the parent Phase II SBIR pro | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| POWERSCOPE INCORPORATED | $16,250 | Grant | Trans-NIH Recovery Act Research Support: This award provides additional funding for 5R44HL081789-03. This additional funding is provided under the American Recovery and Reinvestment Act of 2009 (ARRA) and is | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| ORIGINUS | $12,400 | Grant | Trans-NIH Recovery Act Research Support: The development of drugs aimed at controlling eating disorders represents a major target of the pharmaceutical industry. The long term goal of the parent project is to develop tools for high throughput testing of drug compounds from combinatorial librari | Health and Human Services, Department of / National Institutes of Health | 6/23/2009 |
| HEALTH RESEARCH, INC. | $397,357 | Grant | Trans-NIH Recovery Act Research Support: Project Summary Research is proposed to address PA-04-119 Biodefense and Emerging Infectious Disease Research Opportunities. WNV is a NIAID Category B priority pathogen. The introduction of a single WNV strain at a relatively well characterized time and p | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| UNIVERSITY OF FLORIDA | $329,625 | Grant | Trans-NIH Recovery Act Research Support: Cell death (apoptosis) is implicated in the infectious life cycle of a variety of pathogens, such as the malaria parasite and the West Nile virus, in mosquitoes. Understanding the mechanism of cell death response will help us to develop strategies for co | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| UNIVERSITY OF WASHINGTON | $280,799 | Grant | Trans-NIH Recovery Act Research Support: Retinoic acid (RA) is a critical signaling molecule that regulates cell division and apoptosis. Alterations in RA homeostasis have been linked to several important diseases such as cancer, obesity, Alzheimers disease and type 2 diabetes as well as reprodu | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| AMERICAN FOUNDATION FOR BIOLOGICAL RESEARCH | $59,304 | Grant | Trans-NIH Recovery Act Research Support: To purchase a new image analyzer for my laboratory on NIH parent grant# 5R01AI063480-05 | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC. | $686,377 | Grant | Trans-NIH Recovery Act Research Support: Myelodysplastic syndromes (MDS) are characterized by defective blood formation and high risk for leukemia development and primarily occur in individuals over the age of 65 years old. New strategies of treatment are needed for age-related diseases such as | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | $134,485 | Grant | Trans-NIH Recovery Act Research Support: The Specific Aim of this project is: to examine effects of hyperglycemia, hyperinsulinemia and combined hyperglycemia and hyperinsulinemia on various parameters of blood coagulation in C-peptide negative patients with type 1 diabetes mellitus (T1DM). So | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| TUFTS MEDICAL CENTER PARENT, INC. | $62,942 | Grant | Trans-NIH Recovery Act Research Support: The incidence of type 2 diabete is increasing at an alarming rate both nationally and worldwide with more than 1 million new cases per year diagnosed in the US alone. Vitamin D and calcium are two nutritional factors that have been suspected as modifiers | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE | $152,000 | Grant | Trans-NIH Recovery Act Research Support: This project will accelerate the tempo and achievement of scientific research about undergraduate science education, with specific attention to an enriched, federally-supported intervention aimed at increasing the number of undergraduates from traditional | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| TUFTS MEDICAL CENTER PARENT, INC. | $230,550 | Grant | Trans-NIH Recovery Act Research Support: The goal of this Supplement Award is to enable the PI to pay for a post-doc to speed up some of the experiments proposed under the aims in the PI's grant entitled: G?Hypoxia-induced Endothelial Barrier DysfunctionG?. Under this application we have been i | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| MOREHOUSE SCHOOL OF MEDICINE, INC., THE | $95,000 | Grant | Trans-NIH Recovery Act Research Support: The main aim of this grant (administrative supplement) is to adquire equipments needed to develop the objectives of the parent grant. This grant is related to all Aims described in the Parent Grant that will use leptin peptide receptor antagonists (LPr | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| SAN JOSE STATE UNIVERSITY FOUNDATION INC | $139,607 | Grant | Trans-NIH Recovery Act Research Support: I025, a novel uncultivable bacteria group, has been associated with periodontal disease, which affects 18% of the adult population in the industrialized world. Neither the natural reservoir nor the complete diversity of this group is known. I025 belongs t | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| SAN FRANCISCO STATE UNIVERSITY | $38,555 | Grant | Trans-NIH Recovery Act Research Support: This supplement will accelerate the pace of research that examines the physiological and genetic responses to osmotic stress in yeast.-? This ARRA supplement provides for increased employment of a research assistant from part-time (30 hr/wk) to full time | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| UNIVERSITY CORPORATION, THE | $149,873 | Grant | Trans-NIH Recovery Act Research Support: The nanoscale reading of DNA sequences is envisioned to take place at a nanogap defined by a pair of nanoelectrode tips as a DNA molecule moves through the gate base by base. The rationale is that the four different nucleotide bases and their various sequ | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| MEHARRY MEDICAL COLLEGE | $157,628 | Grant | Trans-NIH Recovery Act Research Support: This is a supplement to the principal investigator's SC3 grant. This project will provide information regarding the role of protease-activated receptors in the regulation of the endothelium, which plays an important role in vascular tone. Endothelial dys | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| ARCADIA BIOSCIENCES, INC. | $921,974 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Celiac disease is an autoimmune digestive disorder in which intestinal lesions develop in genetically susceptible individuals in response to the ingestion of specific cereal seed storage proteins. The only treatment is | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| NORTHWESTERN UNIVERSITY | $772,065 | Grant | Trans-NIH Recovery Act Research Support: We propose to continue an interdepartmental training program for Drug Discovery Training in Age-Related Disorders - a program devoted to providing predoctoral andpostdoctoral scholars with rigorous interdisciplinary training in drug discovery and exposure | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | $5,985,586 | Grant | Trans-NIH Recovery Act Research Support: Project objective: This project will perform annual cognitive evaluations on subjects previously enrolled in the Alzheimer's Disease Anti-Inflammatory Protection Trial (ADAPT). The purpose of these evaluations is to extend observations on the ADAPT outc | Health and Human Services, Department of / National Institutes of Health | 8/12/2009 |
| UNIVERSITY OF FLORIDA | $29,648,216 | Grant | Trans-NIH Recovery Act Research Support: As life expectancy in the United States continues to rise, the maintenance of physical independence among older Americans has emerged as a major clinical and public health priority. Efficient and reliable locomotion, or the ability to move without assista | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $435,147 | Grant | Trans-NIH Recovery Act Research Support: The role of CYP2S1 in asthma Asthma is a condition caused by allergic airway inflammation, or airway hyperresponsiveness, in which the patient periodically experiences paroxysms of wheezing, labored breathing and coughing, due to narrowing and congestion | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF LOUISVILLE | $34,218 | Grant | Trans-NIH Recovery Act Research Support: This was a request for supplemental funding for two undergraduate students to continue to work on EY014701 and its supplement. ?GABAc Receptors and Mouse Retinal Ganglion Cell Responses?. The focus of the research in this grant is the characterization of | Health and Human Services, Department of / National Institutes of Health | 7/09/2009 |
| CHILDREN'S HOSPITAL & RESEARCH CENTER | $198,367 | Grant | Trans-NIH Recovery Act Research Support: The primary specific aim of our parent grant is G?to determine the effects of low glycemic load diets on insulin, carbohydrate, and fat metabolism in obese, pregnant women stratified by visceral fat thickness.G? We hypothesize that a low glycemic load (G | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| WHITEHEAD INSTITUTE FOR BIO-MEDICAL RESEARCH | $975,000 | Grant | Trans-NIH Recovery Act Research Support: The aims of this proposal for supplementary funding are to complete the sequencing and annotation of four chromosomes G?? the mouse, rhesus, and bull Y chromosomes and the chicken Z chromosome G?? within two years. These chromosomes represent half of the | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $43,200 | Grant | Trans-NIH Recovery Act Research Support: The goal of this UCLA-Fogarty Program is to collaborate with Mexican faculty and experts in the development of two virtual education courses, a Chemical Policy and Risk Assessment and Biological Exposure Assessment to address immediate needs to improve tr | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| UNIVERSITY OF ILLINOIS | $0 | Grant | Trans-NIH Recovery Act Research Support: Center for Women's Health & reproduction | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| YALE UNIVERSITY | $50,463 | Grant | Trans-NIH Recovery Act Research Support: ln 3-month paid research experiences, over two summers, 4 talented undergraduate engineering and computer science students will be recruited to contribute in a substantial way to the progress of sub-aims of my parent New lnnovator (DP2) Award; the DP2's m | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $99,180 | Grant | Trans-NIH Recovery Act Research Support: Complicated Grief in Older Adults: The Physiology of Emotion Regulation - The supplement application supports the parent project by increasing the recruitment of diverse older adults in two unique ways: Supplemental Aim 1: recruiting homebound | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $111,879 | Grant | Trans-NIH Recovery Act Research Support: PERCEPTIONS OF SOCIAL USEFULNESS/VALUE AS PREDICTORS OF HEALTH IN OLDER ADULTS The overall purpose of this project is to assess older adults' experience of both burdens and benefits as volunteers in a high-intensity volunteer program, the Experience Cor | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| BAYLOR COLLEGE OF MEDICINE | $240,969 | Grant | Trans-NIH Recovery Act Research Support: 'Statement of Purpose: To incorporate visual aids into science lectures developed by post-docs for undergraduate courses | Health and Human Services, Department of / National Institutes of Health | 7/31/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $98,943 | Grant | Trans-NIH Recovery Act Research Support: HIV AND HEPATITIS B COINFECTION HEPATITIS B GENOTYPE RESISTANCE AND OUTCOMES Explore HBV outcomes in HIV/HBV coinfected individuals including the prevalence of HBV infection and HBV genotypes (SA1), the association between HBV genotype with HBV virologi | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| YALE UNIVERSITY | $331,000 | Grant | Trans-NIH Recovery Act Research Support: Core C, the Cell Culture and Animal Models Core, is an integrated, dedicated, essential component of the Program, which will provide materials and services to all four Projects of the Program. This Core supports the Projects by providing specialized cell | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | $331,124 | Grant | Trans-NIH Recovery Act Research Support: This program project examines the structure, biosynthesis, and roles of carbohydrates in cell-cell interaction. The proposed projects were borne-out from our strong collaborative research activities in the previous funding period. This program project i | Health and Human Services, Department of / National Institutes of Health | 9/10/2009 |
| JOSLIN DIABETES CENTER, INC. | $652,200 | Grant | Trans-NIH Recovery Act Research Support: Diabetes and Endcrinology Research Center (DERC) - During the past 20 years, the DERC, with its Core Laboratories, Enrichment Program and support for Pilot and Feasibility (P&F) studies, has played a major role in fostering expansion in the scope and inte | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| YALE UNIVERSITY | $168,547 | Grant | Trans-NIH Recovery Act Research Support: The human brain consists of approximately 100 billion neurons, which form over 100 trillion synapses with specific targets. How neurons find the correct targets and how the correct wiring of the brain influences behavior are central questions, and the foc | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF MASSACHUSETTS | $80,966 | Grant | Trans-NIH Recovery Act Research Support: For this supplement, I plan to recruit several summer researchers, for summer 2009 and summer 2010, to accelerate the pace of discovery and to provide research opportunities for high school and undergraduate students, as well as a science educator. For s | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| TRUDEAU INSTITUTE INC | $12,460 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this administrative supplement is to obtain salary and a small supply budget for a college student summer research internship. The benefits to this internship are twofold, including (1) acquiring additional staff to expedite a particularly | Health and Human Services, Department of / National Institutes of Health | 6/11/2009 |
| THE HOSPITAL FOR SPECIAL SURGERY FUND INC | $469,996 | Grant | Trans-NIH Recovery Act Research Support: The PROMISSE Study (Predictors of Pregnancy Outcome: bioMarkers In antiphospholipid antibody Syndrome Systemic lupus Erythematosus) is a multi-center, prospective observational study designed to characterize the mechanisms of antiphospholipid (APL) antibo | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| YALE UNIVERSITY | $168,810 | Grant | Trans-NIH Recovery Act Research Support: Epithelial ovarian cancer (EOC) is the fourth leading cause of cancer-related death in women in the United States and is the leading cause of gynecologic cancer death. A major limitation in the treatment of ovarian cancer is the widespread development of | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF NEBRASKA | $133,919 | Grant | Trans-NIH Recovery Act Research Support: The overall objective of this research proposal is to define the multifaceted role of the MUC4 mucin in the pathogenesis of pancreatic cancer (PC). During past funding cycles, we have made considerable progress, beginning with the cloning of the MUC4 cDNA | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| UNIVERSITY OF NEBRASKA | $348,002 | Grant | Trans-NIH Recovery Act Research Support: The parent grant investigates how Cbl family ubiquitin ligase-dependent and ubiquitin-mediated negative regulation negative regulation of EGF receptor is effected at the biochemical and cellular levels and to what extent this physiological negative regula | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| YALE UNIVERSITY | $93,098 | Grant | Trans-NIH Recovery Act Research Support: Abstract The SenseLab suite of 8 interoperable databases is aimed at supporting our research on a model system for brain organization, the olfactory bulb, and at sharing these and related resources with the neuroscience and neuroinformatics communities. D | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF LOUISVILLE | $121,934 | Grant | Trans-NIH Recovery Act Research Support: Project Summary: During development, sensory innervation to taste buds is tightly regulated by the actions of the neurotrophin, brain-derived neurotrophic factor (BDNF). BDNF is expressed in gustatory epithelium and determines whether gustatory neurons wi | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| YALE UNIVERSITY | $200,003 | Grant | Trans-NIH Recovery Act Research Support: Craniofacial malformations are among the most common birth defects in children and lead to substantial morbidity and mortality for these infants. Despite the severity of the illness, little is known about the molecular mechanisms that are necessary for co | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF NEBRASKA | $99,955 | Grant | Trans-NIH Recovery Act Research Support: Kidney transplantation (KTX) improves mortality in patients with end stage renal disease (ESRD), but cardiovascular disease (CVD) remains the most common cause of death and kidney graft loss after KTX. Undertreated traditional CVD risk factors likely cont | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| UNIVERSITY OF NEBRASKA | $90,000 | Grant | Trans-NIH Recovery Act Research Support: Elevated distal flow rates resulting from volume expansion or diuretic therapy increase the delivery of fluid and electrolytes to the distal nephron resulting in stimulation of K+ secretion, often reducing plasma [K+] to critically low levels. It is known | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | $26,557 | Grant | Trans-NIH Recovery Act Research Support: Summary of the parent grant: The parent grant (R01 EB006200-04) proposed the development of a Continuous-Imaging HT Screening Instrument that would allow a 10-fold speed increase over the current Beckman Coulter IC-100 instrument. This increase would be g | Health and Human Services, Department of / National Institutes of Health | 6/16/2009 |
| YALE UNIVERSITY | $478,004 | Grant | Trans-NIH Recovery Act Research Support: High resolution structural, functional and spectroscopic magnetic resonance (MR) imagings of the brain are powerful technologies for the study of epilepsy. Image-guided surgical resection has proven to be an effective treatment for many cases of medically | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $251,266 | Grant | Trans-NIH Recovery Act Research Support: The focus of our U54 Center is on the hormonal and paracrine regulation of spermatogenesis in humans and rodents. There are three interrelated projects. Project I (Barry Zirkin and Jonathan Jarow) is addressing the biological mechanisms that explain why o | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| BROAD INSTITUTE, INC., THE | $9,000,000 | Grant | Trans-NIH Recovery Act Research Support: The funds for this ARRA supplement will be used to scale up our activities in comprehensive cancer genome analysis by sequencing TCGA samples using whole genome or whole exome approaches across multiple cancer types. We are currently working with NHGRI t | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| MEDICAL COLLEGE OF WISCONSIN, INC., THE | $11,005 | Grant | Trans-NIH Recovery Act Research Support: Purpose of this summer project performed by undergraduate summer student was to conduct studies consistent with the parent R01 grant Molecular mechanisms of Axenfeld-Rieger syndrome. The project involved evaluation of the contribution of PITX2 and several | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| YALE UNIVERSITY | $78,408 | Grant | Trans-NIH Recovery Act Research Support: The long term goals of this project are to understand how misfolded RNAs are recognized and handled within cells and to investigate how RNA misfolding impacts cell function. Our focus is on the Ro autoantigen, an RNA-binding protein that is a major target | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| YALE UNIVERSITY | $274,801 | Grant | Trans-NIH Recovery Act Research Support: Reversible protein phosphorylation is one of the most common mechanisms for regulating cell behavior in eukaryotes. Genome sequencing efforts have uncovered hundreds of new predicted protein kinases. For most, we have little insight into their biological | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| YALE UNIVERSITY | $99,650 | Grant | Trans-NIH Recovery Act Research Support: The Na-K-Cl cotransporter (NKCC) is a plasma membrane transport protein that plays a central role in cellular homeostasis. In non-polarized cells including neurons the NKCC1 isoform is involved in regulation of intracellular chloride and cell volume, and | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $245,543 | Grant | Trans-NIH Recovery Act Research Support: This Administrative Supplement to R01GM062631 aims to characterize in detail the molecular interactions between the TPR domain of the telomerase regulatory protein Est1 and telomerase RNA, based on our recent identification of multiple Est1 orthologues in | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $348,878 | Grant | Trans-NIH Recovery Act Research Support: This award is an administrative supplement to R01 GM077560 (Mechanism of ion channel modulation by ligands) which supports the hiring of one postdoctoral fellow, as well as the acquisition of equipment needed to speed up the research being done under the | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| UNIVERSITY OF TENNESSEE | $215,059 | Grant | Trans-NIH Recovery Act Research Support: This Administrative Supplement will focus on the studies proposed in Specific Aim 3 of the parent grant: Specific Aim 3, To Demonstrate that COMBINED mechanical stretch and moderate hyperoxia increases alveolar type II epithelial cell apoptosis via activa | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF MEMPHIS | $262,859 | Grant | Trans-NIH Recovery Act Research Support: The parent award, HL 084007 'Computational Approach to Ligand Discovery for LPA GPCR and PPAR', includes three specific aims that collectively address a single fundamental question. Namely, what structural characteristics confer selective agonist and/or a | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| YALE UNIVERSITY | $313,169 | Grant | Trans-NIH Recovery Act Research Support: Acute kidney injury (AKI) is common in patients undergoing cardiac surgery. Even small increases in serum creatinine portend an increased risk of short-term and long-term death. Serum creatinine, the traditional marker of renal function, only rises appr | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| YALE UNIVERSITY | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: Asthma is characterized by chronic airway inflammation. It is well established that Th2 inflammation and the downstream responses that occur provide much of the underlying basis of asthma pathogenesis. The biologic function of Th2 inflammation is believed | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF MASSACHUSETTS | $170,284 | Grant | Trans-NIH Recovery Act Research Support: The role of microRNAs in the Erythropoietic Stress Response. In aim 1, we will Investigate whether candidate erythroid miRNAs are differentially expressed in erythroid progenitors of mouse models of erythropoietic stress. In aim 2, we wukk investigate w | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $235,888 | Grant | Trans-NIH Recovery Act Research Support: INVESTIGATE STABILITY OF RNA INTERFERENCE IN HUMAN LYMPHOCYTES Our overall hypothesis is that RNA interference (RNAi) can be developed to reduce specific gene expression over long-term without toxic effects in human lymphocytes. RNAi using siRNA to inhib | Health and Human Services, Department of / National Institutes of Health | 8/21/2009 |
| YALE UNIVERSITY | $135,494 | Grant | Trans-NIH Recovery Act Research Support: Several lines of evidence suggest amino acid neurotransmitter system abnormalities contribute to the neurobiology of depression. In humans, there is clear evidence of altered amino acid neurotransmitter function in depressed individuals. Most notably, dep | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $22,484 | Grant | Trans-NIH Recovery Act Research Support: Title of parent grant: Sex chromosome effects on neural development Title of summer project supporting minority student research: The effects of stress and cortagine on propulsive colonic contractions in mice The overall goal of the parent project is to | Health and Human Services, Department of / National Institutes of Health | 7/19/2009 |
| UNIVERSITY OF ARKANSAS SYSTEM | $17,980 | Grant | Trans-NIH Recovery Act Research Support: Sp1, Kappa-B Enhancers and Transcription in Neurons: The parent grant is devoted to explaining the unique ways in which CNS neurons regulate and utilize the transcription factors NF?B and Sp1. Despite a large interest in the potential roles for NF?B in n | Health and Human Services, Department of / National Institutes of Health | 7/27/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $999,264 | Grant | Trans-NIH Recovery Act Research Support: This is an administrative supplement to an RO1 grant which focuses on the generation of genetic and genomic resources for the vervet monkey (Chlorocebus aethiops), also known as the African green monkey. The supplement will accelerate the rate of progress | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| UNIVERSITY OF MASSACHUSETTS | $28,839 | Grant | Trans-NIH Recovery Act Research Support: Upon activation by antigen, B cells undergo antibody class (isotype) switching, changing from expression of IgM to expression of IgG, IgA or IgE, while maintaining specificity for the same antigen. Since the isotype determines the effector function of the | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| WAKE FOREST UNIVERSITY | $31,262 | Grant | Trans-NIH Recovery Act Research Support: Description of overall purpose. The overall purpose of the administrative supplement grant is to increase the scientific value of its parent grant (R15 EB009535-01) by involving 3 additional undergraduates and 1 new high school teacher in our research. | Health and Human Services, Department of / National Institutes of Health | 6/16/2009 |
| UNIVERSITY OF ARKANSAS SYSTEM | $43,123 | Grant | Trans-NIH Recovery Act Research Support: This award is to provide support for hiring of a graduate assistant to help speed the identification of novel CB2 cannabinoid agonists as candidate therapeutics for the devastating, neurodegenerative disease amyotrophic lateral sclerosis (ALS). | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| YALE UNIVERSITY | $250,319 | Grant | Trans-NIH Recovery Act Research Support: Dr Dunne received this ARRA grant as a Biomedical Reentry Grant funded as a supplement to Dr Erol Fikrigs R37 award. The intent of Dr Dunne?s supplement is to supply her with mentorship and skill set development to become an independent investigator. Dr | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $181,175 | Grant | Trans-NIH Recovery Act Research Support: This is an ARRA award to R37 NS032405 entitled, Short Term Synaptic Plasticity in the CNS (central nervous system) to retain an exceptional postdoctoral fellow. These funds are supporting research that is within the general scope of the specific aims of m | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| UNIVERSITY OF ARKANSAS SYSTEM | $223,224 | Grant | Trans-NIH Recovery Act Research Support: Supplement-Expand NCI-supported Community Outreach Capacity through Community Health Educators (CHE) of the National Outreach Network. The AR-CCN, partnering with NCI?s National Outreach Network (NON), seeks to be a catalyst for mobilizing a statewide eff | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $200,200 | Grant | Trans-NIH Recovery Act Research Support: BRAIN BLADDER INTERACTIONS IN IC/PBS Interstitial cystitis/painful bladder syndrome (IC/PBS) is a common chronic bladder syndrome characterized by bladder pain and discomfort (urgency) and increased frequency of urination. It is part of a larger group of | Health and Human Services, Department of / National Institutes of Health | 9/27/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $823,200 | Grant | Trans-NIH Recovery Act Research Support: Title: Community-Based HIV VCT: South Africa NOT-OD-09-058: Description: NIH Announces the Availability of recovery Act Funds for Competitive Revision Applications The protective effect of-male circumcision on HIV acquisition may be due to improved genita | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $208,814 | Grant | Trans-NIH Recovery Act Research Support: This Administrative Supplement, 1/8 Predictors and Mechanisms of Conversion to Psychosis, addresses the NIMH target area Enhancing Risk Prediction through Secondary Data Analysis. We are analyzing existing longitudinal MRI data previously obtained on pro | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $79,065 | Grant | Trans-NIH Recovery Act Research Support: The Cancer Biology Training Grant (CBTG) at the University of Minnesota Masonic Cancer Center combines rigorous training in laboratory-based cancer research with interdisciplinary and translational perspectives that prepares CBTG trainees for independent | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| CORNELL UNIVERSITY, INC | $149,308 | Grant | Trans-NIH Recovery Act Research Support: This renewal proposal describes plans to continue a vigorous chemistry-biology interface (CBI) predoctoral training program that is designed to train scientists in key aspects of fundamental organic and biological chemistry as well as in scientific discip | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $87,156 | Grant | Trans-NIH Recovery Act Research Support: The overarching goal of the Integrative Neuroscience Initiative on Alcoholism (INIA)-West Consortium is to identify the molecular, cellular, and behavioral neuroadaptations that occur in the brain reward circuits associated with the extended amygdala and | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| KUAKINI MEDICAL CENTER | $186,636 | Grant | Trans-NIH Recovery Act Research Support: Our application for an administrative supplement is in response to NOT-OD-09-056: NIH Announces the Availability of Recovery Act Funds for Administrative Supplements. The parent cooperative agreement is 5U01AG017155-08 - Epidemiology of Aging and Dementi | Health and Human Services, Department of / National Institutes of Health | 9/02/2009 |
| HOWARD BROWN HEALTH CENTER | $444,714 | Grant | Trans-NIH Recovery Act Research Support: This recovery act administrative supplement to the Multicenter AIDS Cohort Study (MACS) will support work to discover if the disease variant responsible for host control of HIV resides within the HLA-B/-C haplotype block initially identified by genome-wid | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF PITTSBURGH THE | $1,260,025 | Grant | Trans-NIH Recovery Act Research Support: Multicenter AIDS Cohort Study (MACS): Role of viral coinfections in HIV-1 disease progression in the MACS The overall objective of this proposal is to obtain a comprehensive dataset on herpesvirus and GB virus type C (GBV-C) load in blood and other body | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $1,641,434 | Grant | Trans-NIH Recovery Act Research Support: 'The Study to Help the AIDS Research Effort (SHARE) was funded by NIAID and NCI in 1983 to study the natural history of infection with human immunodeficiency virus, type 1 (HIV). SHARE, along with similar sites in Chicago, Pittsburgh, and Los Angeles, for | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| DREXEL UNIVERSITY | $96,787 | Grant | Trans-NIH Recovery Act Research Support: This project will give undergraduate college students and one summer faculty member from a non-research intensive local college an experience in a professional research lab performing discovery research, as well as exposure to entrepreneurship and commerc | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| J.DAVID GLADSTONE INSTITUTES, THE | $427,526 | Grant | Trans-NIH Recovery Act Research Support: UNAIDS estimates that 14,000 persons are newly infected with HIV every day throughout the world, of which one half are between the ages of 15 and 24. New infections occur despite widespread awareness of the modes of HIV-1 transmission, and the protection | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) | $335,767 | Grant | Trans-NIH Recovery Act Research Support: The objective of this Administrative Supplement is to facilitate clinical validation of a new diagnostic platform for detecting bloodstream infections related to Sepsis by hiring two researchers. The new personnel will increase the tempo of clinical valid | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $784,312 | Grant | Trans-NIH Recovery Act Research Support: This is an application for an administrative supplement to the East Africa Regional IeDEA Consortium (?eDEA-EA), described below, which has approved funding until 8/31/2011. This application aims to create an immediately operational statistical analysis a | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $625,000 | Grant | Trans-NIH Recovery Act Research Support: 1. Accelerating progress on the parent grant, 'Effects of insulin-dependent diabetes resistance alleles on COB tolerance in NOD', by increasing the size of our mouse colonies held at Taconic and at Scripps so that more experiments can be performed in a sh | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| UNIVERSITY OF CINCINNATI | $880,446 | Grant | Trans-NIH Recovery Act Research Support: There are more persons who die from lung cancer than from breast, colon, and prostate cancer combined. The objective of the Genetic Epidemiology of Lung Cancer Consortium (GELCC) is to conduct family-based studies to identify susceptibility genes in famil | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| ST. JUDE CHILDREN'S RESEARCH HOSPITAL | $482,421 | Grant | Trans-NIH Recovery Act Research Support: To date, one must conclude that the pace of progress in disease control and preservation of functional integrity and quality of life for pediatric brain tumors remains below that of most other major types of childhood cancers. Recent advances in cellular | Health and Human Services, Department of / National Institutes of Health | 8/18/2009 |
| ST. JUDE CHILDREN'S RESEARCH HOSPITAL | $381,202 | Grant | Trans-NIH Recovery Act Research Support: To date, one must conclude that the pace of progress in disease control and preservation of functional integrity and quality of life for pediatric brain tumors remains below that of most other major types of childhood cancers. Recent advances in cellular | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $350,604 | Grant | Trans-NIH Recovery Act Research Support: Although the costs of Prostate-Specific Antigen (PSA) screening for prostate cancer have been clearly documented, the benefit is still uncertain despite the recent publication of two large-scale screening trials. The US trial found no benefit of PSA scree | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $459,344 | Grant | Trans-NIH Recovery Act Research Support: The central theme of our research under is to develop lentiviral engineered T cells for treatment of HIV. After successful completion of the aims as set forth in our original IPCP application, we find ourselves in a unique position to directly compare len | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $126,814 | Grant | Trans-NIH Recovery Act Research Support: The threat of radiological attacks has grown in recent years, warranting a concerted effort to translate the molecular advances of radiation research into bonafide medical products. These medical products must be directed toward the identification and tre | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $1,620,774 | Grant | Trans-NIH Recovery Act Research Support: Current HIV-1 vaccine candidates based on recombinant adenovirus serotype 5 (rAd5) vectors are promising but may prove limited by the high prevalence of pre-existing anti-Ad5 immunity in the developing world. To overcome this problem, we have constructed | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $99,784 | Grant | Trans-NIH Recovery Act Research Support: It is planned to apply the stochastic model developed earlier to breast cancer issues associated with the U.S. population. Among the issues which will be studied are: estimating the U.S. breast cancer mortality for the period 2005-2020; investigate mortal | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| PAPA OLA LOKAHI INC | $200,000 | Grant | Trans-NIH Recovery Act Research Support: This award will be used to expand Imi Hale Native Hawaiian Cancer Network's capacity to meet the demand for culturally tailored cancer education expressed by agencies serving Native Hawaiians and Pacific Islanders. Imi Hale has invested 10 years in the de | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| THE VANDERBILT UNIVERSITY | $716,165 | Grant | Trans-NIH Recovery Act Research Support: The non invasive approach to the diagnosis of lung cancer remains a priority in biomarkers development at a time when markers of response and of prognosis are being developed rapidly. These should help us detect the disease at the preclinical level and po | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| THE GEORGE WASHINGTON UNIVERSITY | $313,000 | Grant | Trans-NIH Recovery Act Research Support: The Center to Reduce Cancer Health Disparities (CRCHD) of the National Cancer Institute (NCI) announced, for the fiscal year of 2010-11, the opportunity for grantees to seek administrative supplemental funding for cancer health disparities (CHD) planning | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF CINCINNATI | $397,300 | Grant | Trans-NIH Recovery Act Research Support: Hepatocellular carcinoma (HCC) accounts for an estimated 600,000 deaths annually, and in North America mortality due to HCC has nearly doubled in the last 20 years. Recently it has been shown that the signaling pathway controlled by the mammalian Target O | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $305,756 | Grant | Trans-NIH Recovery Act Research Support: This proposal builds on a rich resource of bladder cancer (BC) cases and controls derived from two ongoing BC studies at the University of Texas M.D. Anderson Cancer Center, and from two large independent U.S. BC studies - the New England BC Study and the | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| ST LUKE'S-ROOSEVELT HOSPITAL CENTER | $129,487 | Grant | Trans-NIH Recovery Act Research Support: Purpose of the Supplement: This Administrative Supplement to Look AHEAD will increase the scientific impact of Look AHEAD and retain and/or create new staff positions at each of 15 local sites and the Coordinating Center. These requests parallel the submi | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $90,846 | Grant | Trans-NIH Recovery Act Research Support: Look AHEAD is randomized clinical trial examining the long-term health effects of an intensive weight loss intervention in approximately 5,145 overweight volunteers with type 2 diabetes. Participants are randomized to an intensive lifestyle intervention d | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| KAISER FOUNDATION HOSPITALS | $102,277 | Grant | Trans-NIH Recovery Act Research Support: We will hire one additional full-time Research Assistant for 10 months to work on the CRIC Study. The proposed personnel addition will allow us to accelerate the tempo of the CRIC Study at our Clinical Center by streamlining and speeding up the ascertainm | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $361,821 | Grant | Trans-NIH Recovery Act Research Support: ARRA - Clinical Study of Vesicoureteral Reflux in Children. This project has two primary objectives related to the on-going RIVUR trial. One objective is to develop a centralized medical image data management system for use in the RIVUR study. The seco | Health and Human Services, Department of / National Institutes of Health | 8/21/2009 |
| UNIVERSITY OF MARYLAND | $1,147,846 | Grant | Trans-NIH Recovery Act Research Support: The Human Microbiome Project (HMP) is an NIH Roadmap program that will produce unprecedented amounts of information about the microbial communities living on and within humans. The objective of our current work is to provide a Data Analysis and Coordinati | Health and Human Services, Department of / National Institutes of Health | 9/10/2009 |
| RHODE ISLAND HOSPITAL | $202,428 | Grant | Trans-NIH Recovery Act Research Support: Project iMPPACS provides the first large-scale test of a culturally targeted TV and radio campaign to reduce HIV-associated sexual risk behavior among 1,600 African-American teens in four mid-sized cities in the U.S. Initial findings offer evidence of pro | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| WASHINGTON UNIVERSITY, THE | $1,571,661 | Grant | Trans-NIH Recovery Act Research Support: Silent Cerebral Infarct (SCI) is the most common cause of severe neurological disease in children with sickle cell anemia, occurring in 22% of this population prior to their 18th birthday. The overall goal of this trial is to determine whether blood trans | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| UNIVERSITY OF CINCINNATI | $335,100 | Grant | Trans-NIH Recovery Act Research Support: Intravenous recombinant tissue plasminogen activator (IV rt-PA) is an effective therapy for acute ischemic stroke but has substantial limitations when used alone to open occluded major extracranial and intracranial arteries. The EMS and IMS I Pilot Studie | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| UNIVERSITY OF PITTSBURGH THE | $455,136 | Grant | Trans-NIH Recovery Act Research Support: The award issued under the American Recovery and Reinvestment for the period 9/30/09-9/29/11 is a supplement to current grant entitled 'Biostatistical Center for the NSABP'. The National Surgical Adjuvant Breast and Bowel Project (NSABP) is a clinical tr | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF HOUSTON SYSTEM | $82,167 | Grant | Trans-NIH Recovery Act Research Support: The cohort for this project is a group of 400 (111 of the original 118 at the UH site are still active and we expect to examiner 108 in year 11 of the study) ethnically diverse, myopic young adults currently 17-123 years of age with 11 years of standardiz | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| NEW ENGLAND COLLEGE OF OPTOMETRY, THE | $82,767 | Grant | Trans-NIH Recovery Act Research Support: To conduct preliminary comparisons of measurements of macular thickness, optic disc parameters, intraocular pressure (IOP) and central corneal thickness (CCT) between non-myopic young adults and COSMICC subjects. The study is designed to test 2 hypothese | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| GEORGETOWN UNIVERSITY (THE) | $41,706 | Grant | Trans-NIH Recovery Act Research Support: GirlTalk is a research program with a goal to extend interpregnancy intervals for parenting teen mothers through building their positive relationships, healthy reproductive practices and strong youth assets to enhance attitudes and behaviors associated wi | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | $251,181 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Pelvic floor disorders (PFD) including urinary incontinence, pelvic organ prolapse (POP), and fecal incontinence affect a substantial proportion of women in the U.S. PFD result in significant psychosocial costs to an i | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $744,332 | Grant | Trans-NIH Recovery Act Research Support: The new scientific project described in this administrative supplement application is designed to advance in a complementary fashion the primary objectives of our original U19 award -the discovery and validation of biomarkers for kidney transplantation an | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| THE INSTITUTE FOR CANCER RESEARCH | $98,316 | Grant | Trans-NIH Recovery Act Research Support: Supplemental funds are requested for the recently awarded U19AI083008, G?Immune Mechanisms That Control Ectromelia Virus (ECTV) InfectionG? (PI, Sigal, 5/1/2009-4/30/2014). The requested supplemental funds will be used for the purchase of equipment to be | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $570,000 | Grant | Trans-NIH Recovery Act Research Support: We intend to use chemical screening to identify novel inhibitors of infection by influenza virus H1N1 and their cellular or viral targets. Such inhibitors may permit the development of drugs that act in a new way to block influenza broadly, checking the r | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| HOUSE EAR INSTITUTE INC | $261,492 | Grant | Trans-NIH Recovery Act Research Support: To increase the number of temporal bone pledges from select ear diseases and to develop specimen-processing techniques for future temporal bone acquisitions - as well as protocols for bones currently in the HEI collection - that will allow the application | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| PURDUE UNIVERSITY | $305,000 | Grant | Trans-NIH Recovery Act Research Support: Basic knowledge of the biochemistry, molecular biology, and genetics of Escherichia coli K-12 may be more advanced than for any other organism. This information ranges from environmental physiologic responses down to the atomic level. While many databases | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $926,175 | Grant | Trans-NIH Recovery Act Research Support: The overarching goal of the Function BIRN (FBIRN) is to develop technology and methods to conduct multi- site functional imaging studies, and to produce a knowledge base that would not otherwise be available through single-site imaging studies. The techno | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF MIAMI | $497,833 | Grant | Trans-NIH Recovery Act Research Support: Type 1 Diabetes is a series disease for which there is no cure but palliative treatments. Islet transplantation might represent, if successful, a cure. The ICR has provided islets of uncompromised quality for basic science, preclinical and clinical stud | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF MASSACHUSETTS | $72,971 | Grant | Trans-NIH Recovery Act Research Support: This is a supplement to create a partnership in environmental public health. Within The New England Consortium's hazardous waste worker health and safety training project we will develop a short training curriculum to prepare worker health and safety and | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF MARYLAND | $669,831 | Grant | Trans-NIH Recovery Act Research Support: Each year, novel strains of influenza A virus arise through mutation and manage to infect one-fifth of the human population. We remain woefully ignorant of what specific features determine the success or failure of these antigenic drift variants. As a res | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF PUERTO RICO-MEDICAL SCIENCES CAMPUS | $911,078 | Grant | Trans-NIH Recovery Act Research Support: This award is for the recruitment of Dr. Maribel Tirado-Gomez. Dr. Tirado-Gomez's immediate career goals are to develop proficiency in cancer research having the financial and time resources to allow her development as an independent researcher in the ca | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| MOREHOUSE SCHOOL OF MEDICINE, INC., THE | $278,600 | Grant | Trans-NIH Recovery Act Research Support: This award is to support the recruitment and retention of research staff. The goal of this project is to understand the role of cancer genes in prostate cancer. This knowledge will facilitate an understanding of the functional role of cancer genes which w | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| EMORY UNIVERSITY | $300,000 | Grant | Trans-NIH Recovery Act Research Support: As part of the NCI Centers of Cancer Nanotechnology Excellence (CCNE) at Emory and Georgia Tech, we request supplemental support to accelerate the tempo in developing, standardizing, and scaling up two nanoparticle-based cancer drugs - one for targeting f | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $99,985 | Grant | Trans-NIH Recovery Act Research Support: As CCNE-TR investigators, we are convinced that nanotechnology will make a significant impact on cancer diagnosis and management in potentially revolutionary ways. We share the NCI?s vision that nanoscience applied to cancer research is critical to the fu | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $309,000 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this Supplement to the Comprehensive SDSU-UCSD Cancer Center Partnership (U54 CA132379) is to achieve objectives that are an extension of the parent grant. This Supplement Community Health Educator Administrative Supplement directly address | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| VIRGINIA COMMONWEALTH UNIVERSITY | $120,908 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement proposal requests funds to expand the research scope of Project II ('Pharmacogenetics of Metformin Action in PCOS') of the VCU SCCPRIR program by hiring a part-time Clinical Research Coordinator whose specific role will be t | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| WASHINGTON UNIVERSITY, THE | $10,000,000 | Grant | Trans-NIH Recovery Act Research Support: The project proposed additional TCGA sequencing and analysis. We propose an approach that combines the power of four distinct sequencing methods to discover somatic events in human cancer genomes, and that should scale linearly depending on the funds ava | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF WASHINGTON | $900,000 | Grant | Trans-NIH Recovery Act Research Support: In this Administrative Supplement request, we propose funding to expand the UW ENCODE Project in four key areas. First, we plan to perform deep sequencing / digital genomic footprinting for 15 additional cell types. Second, we plan to boost DHSs that h | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF PUERTO RICO-MEDICAL SCIENCES CAMPUS | $295,800 | Grant | Trans-NIH Recovery Act Research Support: This supplement will be used for conducting the following four activities and actions that will mainly provide experiences that educate clinical and translational scientists in the creation of partnerships that promotes translational research: 1. Training | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| MOREHOUSE SCHOOL OF MEDICINE, INC., THE | $400,000 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of the Morehouse School of Medicine (MSM) RCMI Center of Excellence in Clinical and Translational Research (R-CENTER) is to train the next generation of minority clinical and translational scientists to pursue multidisciplinary approach | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC. | $329,731 | Grant | Trans-NIH Recovery Act Research Support: There are many efforts and current initiatives to ameliorate disparities, yet the burden of cancer remains high particularly among many racial/ethnic groups. In order to address this problem, NCIG??s Center to Reduce Health Disparities (CRCHD) seeks to ma | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| DUKE UNIVERSITY | $598,935 | Grant | Trans-NIH Recovery Act Research Support: The proposed project will promote expanded and improved community engagement (CE) by academic medical centers (AMCs) through two related activities: 1) collaboratively rewriting the CDC's seminal 'Principles of Community Engagement' (PCE), and 2) implemen | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| DUKE UNIVERSITY | $599,581 | Grant | Trans-NIH Recovery Act Research Support: This application is in response to the NCRR Administrative Supplements for Research Workforce Development and Dissemination. Training in Health Informatics for practitioners, clinical and translational scientists, and healthcare leaders is critical to two | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $599,999 | Grant | Trans-NIH Recovery Act Research Support: This NCRR Administrative Supplement Request for Research workforce Development and Dissemination seeks support for the Irving Institute for Clinical and Translational Research (IICTR) at Columbia University seeks to leverage its clinical/translational (C/ | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF IOWA, THE | $997,575 | Grant | Trans-NIH Recovery Act Research Support: An essential element of the RFA entitled Institutional Clinical and Translational Science Award, CTSA, is the creation of an academic home that is a department, center, or institute. In response to the RFA, the University of Iowa will create The Universit | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $271,743 | Grant | Trans-NIH Recovery Act Research Support: The Ohio State University (OSU) Center for Clinical and Translational Science (CCTS) will develop a Summer Research Experience Program (SREP) to employ high school students and science teachers to work with clinical and translational research studies at O | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $400,000 | Grant | Trans-NIH Recovery Act Research Support: In May 2008 The Ohio State University was awarded a Clinical and Translational Science Award to improve the quality of patient care in the community through a transformative clinical and translational science discipline that is at the core of the academic | Health and Human Services, Department of / National Institutes of Health | 8/25/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO | $986,867 | Grant | Trans-NIH Recovery Act Research Support: This Recovery Act Administrative Supplement requests funding to advance and accelerate the translational research programs being supported by the Imaging Core of the Clinical and Translational Science Award (CTSA) program of the University of Texas Health | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $100,000 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this proposal is to define signaling pathways that control oncogenic transformation and epithelial to mesenchymal transition (EMT) of lung cancer cells. The secreted Wnt proteins, which signal through the Frizzled (Fz) family of seve | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| TUFTS MEDICAL CENTER PARENT, INC. | $50,000 | Grant | Trans-NIH Recovery Act Research Support: The principal investigator conducts translational research in Human Immunodeficiency Virus (HIV) and explores questions relating to HIV drug resistance and the impact of low-frequency mutations on clinical outcomes. | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $100,000 | Grant | Trans-NIH Recovery Act Research Support: Lung involvement is currently the leading cause of morbidity and mortality in scleroderma (SSc) patients. Interstitial lung disease (ILD) is the most common pulmonary manifestation and may result from an abnormal immune response carried out by pro-fibroti | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $74,130 | Grant | Trans-NIH Recovery Act Research Support: Overview: Although there is consensus that HIV accelerates hepatitis C (HCV) disease in co-infected (HIV+HCV+) patients, studies differ regarding the impact of HCV infection on HIV disease progression. This proposal seeks continued support for our grant H | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | $15,168 | Grant | Trans-NIH Recovery Act Research Support: This project seeks an administrative supplement to support an undergraduate summer student to work in the Glickman lab in the summer of 2010. The student was recently identified. The funding of this supplement will both accelerate the pace of discovery | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| SEATTLE CHILDREN'S HOSPITAL | $304,169 | Grant | Trans-NIH Recovery Act Research Support: Reservoirs of drug-resistant HIV-1 -- Antiretroviral drugs have radically modified the course of HIV-1 disease among individuals with access to these chemotherapeutics. The selection of drug-resistant viruses, however, can markedly foreshorten the bene | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| WISTAR INSTITUTE OF ANATOMY & BIOLOGY | $150,000 | Grant | Trans-NIH Recovery Act Research Support: This project's goal is to use a well-characterized model system to define processes governing the formation and activity of CD4+CD25+Foxp3+ regulatory T (Treg) cells. The proposal will make use of existing lineages of transgenic mice expressing the influe | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $1,920,915 | Grant | Trans-NIH Recovery Act Research Support: This Request is the New Hampshire portion of a regional effort from the northeast IDeA states (VT, NH, ME, RI and DE) to provide the first fiber-optic backbone through northern New England that connects higher-education and biomedical research institution | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| NORTH DAKOTA STATE UNIVERSITY | $172,157 | Grant | Trans-NIH Recovery Act Research Support: The extent to which individuals are vigilant for, versus avoidant of, threatening information has been posited to play a major role in a variety of health outcomes. However, threat-related processing styles have not been adequately assessed in terms of wh | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| NORTH DAKOTA STATE UNIVERSITY | $203,332 | Grant | Trans-NIH Recovery Act Research Support: A major goal of research on human aging is to generate knowledge that will facilitate the maintenance of functional independence in older adult populations. Sensory declines represent a broad category of normal age-related changes that can lead to diminis | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $770,000 | Grant | Trans-NIH Recovery Act Research Support: Epilepsy affects about 2.5 million people in the United States. If not properly controlled by antiepileptic drugs, seizure disorders can lead to lower quality of life and loss of productivity. One class of epilepsy is called idiopathic generalized epileps | Health and Human Services, Department of / National Institutes of Health | 9/20/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $221,250 | Grant | Trans-NIH Recovery Act Research Support: Cilia are microtubule-based organelles that have long been observed on most mammalian cells. While their presence has been known, their diverse functions in mammalian development and signaling are poorly understood. Cilia have recently been shown to be | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF TEXAS AT ARLINGTON | $141,711 | Grant | Trans-NIH Recovery Act Research Support: One of the major challenges in nanomedicine is to improve nanoparticles cell selectivity and adhesion efficiency through designing functionalized nanoparticles of various shapes, sizes, and materials. Recent data on cylindrically shaped filomicelles are b | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY | $145,826 | Grant | Trans-NIH Recovery Act Research Support: Well-regulated attention and memory processes are critical to healthy cognitive development in childhood and beyond. Although nearly all children show dramatic improvements in their self-regulation of these cognitive processes, the etiology of individual | Health and Human Services, Department of / National Institutes of Health | 8/12/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $449,625 | Grant | Trans-NIH Recovery Act Research Support: With Malaria as a major global health burden, the emergence and spread of antimalarial resistance presents a significant threat to control efforts. The genetic basis of drug resistance is not completely understood. We need new approaches to identify both | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| NEW MEXICO STATE UNIVERSITY | $353,950 | Grant | Trans-NIH Recovery Act Research Support: Dengue virus is a mosquito-transmitted pathoghen that causes millions of cases of severe disease worldwide every year because there are no vaccines to prevent dengue infection and no antiviral medications to treat dengue disease. A newly-discovered pathw | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| LOYOLA UNIVERSITY | $411,125 | Grant | Trans-NIH Recovery Act Research Support: This R21 exploratory / development grant is being used to determine how the cellular ubiquitin-proteasome system interacts with coronaviruses. Coronaviruses are common respiratory pathogens capable of causing severe epidemic disease. We discovered that | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION | $402,875 | Grant | Trans-NIH Recovery Act Research Support: The mucosal immune system must remain tolerant to commensal bacteria and food antigens, yet still maintain the capacity to trigger inflammatory responses to pathogenic microorganisms. The process of initiating inflammatory adaptive immune responses to in | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $54,000 | Grant | Trans-NIH Recovery Act Research Support: Hypertension affects approximately 25% of the adult population in the United States and is an important risk factor for death from stroke, myocardial infarction, congestive heart failure, and chronic kidney disease. The distal convoluted tubule (DCT) of t | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $54,000 | Grant | Trans-NIH Recovery Act Research Support: The human digestive tract is colonized with a dense community of microbes known at the intestinal microbiota. Many normal physiological processes and developmental programs are reliant upon the presence and proper function of the microbiota. In addition, | Health and Human Services, Department of / National Institutes of Health | 8/24/2009 |
| TEXAS A&M UNIVERSITY SYSTEM,THE | $53,950 | Grant | Trans-NIH Recovery Act Research Support: This application describes a comprehensive research program designed to develop Dr. DeMorrow into an independent research scientist. Through a structured program of seminars, conferences and workshops throughout the duration of the K01 award, she will acq | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $54,000 | Grant | Trans-NIH Recovery Act Research Support: Helicobacter pylori are gram-negative pathogens that infect more than 3.5 billion people worldwide. The work proposed here will explain how DNA damage to H. pylori induces DNA exchange and will lead to treatment modalities that target this process. Such | Health and Human Services, Department of / National Institutes of Health | 7/28/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $49,431 | Grant | Trans-NIH Recovery Act Research Support: Initially funded for a one-year period, the administrative supplement award, K02-AI076123-S1, has received a 6-month no-cost extension that started on July 1, 2010. Despite a modest budget ($49,431 in total costs), this award has contributed to: a) the p | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| MICHIGAN STATE UNIVERSITY | $49,038 | Grant | Trans-NIH Recovery Act Research Support: Recent advances on retroviral research that members of APOBEC3 (A3) subfamily proteins potently blocks replication of retroviruses have opened a new avenue for the development of antiretroviral therapy for human immunodeficiency virus type 1 (HIV-1) infec | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $108,000 | Grant | Trans-NIH Recovery Act Research Support: The ARA funds were used to hire a 50% SRA (statistical research associate) for a two year period to work with Dr. Vaughan in making optimal use of key research opportunities. This will a) enable the hiring of additional technical staff with needed skills | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON | $108,000 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project for an Established Investigator Award in Cancer Prevention, Control, Behavioral, and Population Sciences is to allow Dr. Goodwin to reduce his administrative responsibilities so that he can devote 70% time to mentoring junior facu | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $104,710 | Grant | Trans-NIH Recovery Act Research Support: Each year, 51,200 people in the US are diagnosed with bladder cancer and 10,600 die of the disease. In addition to tumor invasiveness, metastatic state and nuclear grade, somatic alterations in tumor suppressor genes have been proposed as useful prognosti | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF IOWA, THE | $107,950 | Grant | Trans-NIH Recovery Act Research Support: This K07 Career Development Award application is designed to expand my career development from cancer etiology to cancer prevention and control. The career development plan rests on mentoring directed by experts in cancer prevention research and 'protecte | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| GEORGETOWN UNIVERSITY (THE) | $78,487 | Grant | Trans-NIH Recovery Act Research Support: Project title: Molecular Mechanisms of Invadopodia Formation and Function. The objective of this K99 supplement is to supplement the studies proposed under my parental K99/R00 with high-throughput screening analyses that will significantly accelerate iden | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF PITTSBURGH THE | $26,894 | Grant | Trans-NIH Recovery Act Research Support: This application aims to supplement an active K99 award (NIDCR K99 DE-018954-01, Matrix metalloproteinase gene variants and cleft lip/palate) with the purpose of adding technical personnel. The supplement would allow to promote job creation and economic d | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY | $457,032 | Grant | Trans-NIH Recovery Act Research Support: Viruses and Autoimmunity: P01: The hypothesis that human enterovirus infections have the potential to accelerate type 1 diabetes (T1D) onset in humans is well supported by both observational and experimental data. However, epidemiological data as well as | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, THE | $100,000 | Grant | Trans-NIH Recovery Act Research Support: The application of PET to evaluate the health and safety of nanomaterials will offer a deep and broad understanding of nanoparticle behavior, revealing the pathways nanomaterials take in living systems and identifying some of the acute and long-term effec | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $387,803 | Grant | Trans-NIH Recovery Act Research Support: This submission is in response to NOT-OD-09-058, entitled 'NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications.' Enzymatic targeting of a radiopharmaceutical for the treatment of EBV-associated tumors is a novel stra | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | $194,238 | Grant | Trans-NIH Recovery Act Research Support: The central theme of this Program Project involves the relationship among molecular structure, thermodynamics, and biological function. By developing novel biological systems that reflect the mutagenic specificity of a single DNA adduct and by using NMR s | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| LOYOLA UNIVERSITY | $368,361 | Grant | Trans-NIH Recovery Act Research Support: Patients treated with topoisomerase inhibitors as part of chemotherapy for solid tumors, develop secondary leukemias with translocations involving the MLL gene, at a rate of up to 5%. The project will involve the use of parallel sequencing of inverted PCR | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF PITTSBURGH THE | $303,000 | Grant | Trans-NIH Recovery Act Research Support: The Administrative Supplement provides funding for two aspects of our rapidly expanding studies in the field of cancer-induced immune suppression. The proposed additional studies focus on newly discovered and potentially critically important mechanisms o | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $488,024 | Grant | Trans-NIH Recovery Act Research Support: Pancreatic ductal adenocarcinoma (PDAC) is among the leading causes of cancer death, with nearly all cases following a rapid and merciless course of intractable pain, cachexia, hopelessness and death. Repeated cycles of clinical trial failures have unders | Health and Human Services, Department of / National Institutes of Health | 9/20/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $8,200 | Grant | Trans-NIH Recovery Act Research Support: This project explores how a gene family of multi-PDZ domain proteins called the NHERF family which are located in the apical domain of epithelial cells takes part in regulation of intestinal Na absorption by affecting the brush border Na/H antiporter NHE3 | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| UNIVERSITY OF NORTH CAROLINA AT WILMINGTON | $799,999 | Grant | Trans-NIH Recovery Act Research Support: This amended Program Project competitive renewal is focused on revealing mechanisms of action following Florida red tide toxin exposure in laboratory models, and at providing relevant information for humans exposed on beaches. Florida red tides caused by | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF MIAMI | $122,400 | Grant | Trans-NIH Recovery Act Research Support: Genetic Studies in Neurological Disorders To date, researchers have completed sequencing 576 individuals for 32 primer sets covering the exonic regions of MECP2, MBD5, MBD6, SETDB1, and SETDB2. From these preliminary results, we have identified 46 variati | Health and Human Services, Department of / National Institutes of Health | 8/18/2009 |
| UNIVERSITY OF KENTUCKY | $82,849 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement is based upon our current Program Project Grant (PPG) entitled Calpain as a Therapeutic Target for TBl which is beginning its third year of 5 years of funding. The requested funding for three projects and two cores will enab | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| WAKE FOREST UNIVERSITY | $272,762 | Grant | Trans-NIH Recovery Act Research Support: This P20 proposal presents a research and educational partnership between the Wake Forest University Comprehensive Cancer Center (WFUCCC) and the Departments of Biology and Chemistry of North Carolina Agricultural and Technical University (NC A&T). The ob | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF TEXAS - PAN AMERICAN | $168,874 | Grant | Trans-NIH Recovery Act Research Support: The Latino/Hispanic population is the largest minority in the US and the highest concentration of Latinos is along the US-Mexico Border. To address the specific needs of this population in cancer research and education, a partnership between The Universit | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE | $450,293 | Grant | Trans-NIH Recovery Act Research Support: The University of Vermont (UVM) has a long and venerable history of research using rodent models of environmental lung disease developed within a dedicated inhalational exposure facility housed in the College of Engineering at UVM. This facility has been | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF ALASKA FAIRBANKS | $957,627 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of the proposed COBRE-funded Center for Alaska Native Health Research (CANHR) is to achieve a permanent and sustainable research center at the University of Alaska Fairbanks (UAF) with the primary theme of investigating obesity and chroni | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $796,712 | Grant | Trans-NIH Recovery Act Research Support: This two-year proposal is designed to establish a research framework of excellence that can be used to develop new translational insights into the mechanism of heart valve disease with the aim of improving therapy. Our specific goal is to understand the i | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF HAWAII SYSTEMS | $95,170 | Grant | Trans-NIH Recovery Act Research Support: COBRE: Center for Cardiovascular Research We are submitting this renewal application for the Center of Biomedical Research Excellence (COBRE) at the University of Hawaii (UH) in response to the National Institutes of Health RFA-RR-06-001. The John A. Burn | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| UNIVERSITY OF ALASKA FAIRBANKS | $600,000 | Grant | Trans-NIH Recovery Act Research Support: Biomedical workforce training in Alaska requires starting with the early foundation in the high schools in isolated local villages. By engaging students in research early, we engage their parents and communities. Once begun, we attempt to nudge students | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| MARSHALL UNIVERSITY RESEARCH CORPORATION | $529,094 | Grant | Trans-NIH Recovery Act Research Support: West Virginia is a State that has had a historically low success rate in obtaining grant awards from the National Institutes of Health and has been designated as an IDeA State. Marshall University (MU), in partnership with West Virginia University (WVU), | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| NEW MEXICO STATE UNIVERSITY | $587,303 | Grant | Trans-NIH Recovery Act Research Support: ?Zuni Health Initiative (ZHI) is a NM-InBRE supported (P20 RR016480) community based education project with a major goal of reduction of risk for obesity- and diabetes-related chronic diseases in the traditional Zuni community. The major objective of thi | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF KENTUCKY | $511,802 | Grant | Trans-NIH Recovery Act Research Support: Aerobic organisms exploit O2 to extract large amounts of energy from oxidative metabolism of food, and employ oxidative reactions for a number of important chemical transformations involved in antibiotic biosynthesis, metabolism of xenobiotics, constructi | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| UNIVERSITY OF WASHINGTON | $727,073 | Grant | Trans-NIH Recovery Act Research Support: Protein interaction networks are key determinants of protein function in biological systems. Despite the potential that quantitative protein interaction information could have for all areas of cancer research, global or large-scale quantitation of protei | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| MICHIGAN STATE UNIVERSITY | $746,469 | Grant | Trans-NIH Recovery Act Research Support: The goal of this study is to identify underlying mechanisms, which hinder routine high-level expression of integral membrane proteins using the baculovirus expression system. In this study a rapid cloning system will be employed to generate recombinant ba | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| CORNELL UNIVERSITY, INC | $200,200 | Grant | Trans-NIH Recovery Act Research Support: Genetically encoded Ca2+ sensors hold great promise for the dissection of complex physiology in vivo. The ability to make molecular scale measurements in real time in mammals, and to determine lineage G??specific signaling events by genetic specification | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $627,280 | Grant | Trans-NIH Recovery Act Research Support: The goal of this proposal is to identify the enzymes involved in mammalian mitochondrial one-carbon metabolism and to determine how these enzymes function together to support mitochondrial one-carbon metabolism. Folic acid metabolism is essential in all c | Health and Human Services, Department of / National Institutes of Health | 8/07/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $367,463 | Grant | Trans-NIH Recovery Act Research Support: During the past decade, it has become evident that in vitro enzyme data obtained in solution frequently fail to provide an accurate profile of in vivo enzyme kinetic parameters. This may be due to oligomer formation. Efforts to separate the effect of olig | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| RHODE ISLAND HOSPITAL | $589,576 | Grant | Trans-NIH Recovery Act Research Support: Type I interferons (IFNa,b) have been widely used for treatment of cancer and virus-infected diseases. Our recent findings suggest that IFN-alpha can have a previous totally unknown signaling event, i.e., lysine acetylation cascade, leading to anti-prolif | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| DUKE UNIVERSITY | $608,023 | Grant | Trans-NIH Recovery Act Research Support: Cdk/Cyclin complexes drive progression through the eukaryotic cell cycle. Entry into mitosis is triggered by Cdk1 (Cdc2)/Cyclin B complexes, while M phase exit requires Cyclin B degradation and dephosphorylation of mitotic phosphoproteins. The destruction | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $759,600 | Grant | Trans-NIH Recovery Act Research Support: The overall purpose of the award is to conduct a lentiviral shRNA screen in human T cells and identify novel genes that are required for T cell receptor signaling and T cell activation. In year 1, we will conduct the full-scale 15,000 shRNA screen. We hav | Health and Human Services, Department of / National Institutes of Health | 9/08/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON | $1,342,403 | Grant | Trans-NIH Recovery Act Research Support: Minority children are more likely to experience early academic failure than are non-minority children. Increased risk of academic failure is associated with a host of family factors such as family poverty, maternal depression, low maternal education, and | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $754,587 | Grant | Trans-NIH Recovery Act Research Support: Post-stroke shoulder pain is a major rehabilitation problem affecting up to 60% of moderate to severely impaired stroke survivors. Surface electrical stimulation (ES) of muscles surrounding the hemiparetic shoulder is the only intervention with evidence o | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| TEACHERS COLLEGE, COLUMBIA UNIVERSITY | $359,809 | Grant | Trans-NIH Recovery Act Research Support: We use a multilevel data set (PHDCN) to study young children?s emerging effortful control (EC) in diverse neighborhoods throughout Chicago. We test the explanatory power of characteristics from three environmental contexts -- the mother-child relationship | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $762,867 | Grant | Trans-NIH Recovery Act Research Support: How animals regulate organ size is unknown. Recent studies in Drosophila point towards a novel signaling pathway called hippo as an important regulator of organ growth. Cells that are mutant for components of the hippo signaling pathway exhibit features o | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| THE VANDERBILT UNIVERSITY | $923,331 | Grant | Trans-NIH Recovery Act Research Support: The principal determinant of synaptic serotonin (5-hydroxytryptamine; 5-HT) inactivation is the antidepressant-sensitive 5-HT transporter (SERT, SLC6A4). Common polymorphisms in the SERT promoter impact SERT expression and have been associated with anxiet | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $856,157 | Grant | Trans-NIH Recovery Act Research Support: Today, ontologies are critical instruments for biomedical investigators, especially in those areas, such as cancer research, that require the command of a vast amount of information and a systemic approach to the design and interpretation of experiments. | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $740,000 | Grant | Trans-NIH Recovery Act Research Support: Molecular regulation of the myocardin factors in vascular smooth muscle- ARRA Vascular smooth muscle cell (SMC) differentiation is a very important process during vasculogenesis and angiogenesis, and it is well recognized that alterations in SMC phenotyp | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $1,034,638 | Grant | Trans-NIH Recovery Act Research Support: Our approach in elucidating critical pathways involved in the pathogenesis of human COPD has been to identify candidate genes from a comprehensive study of regulated genes in human lung tissues of individuals with COPD. We performed comprehensive gene exp | Health and Human Services, Department of / National Institutes of Health | 5/30/2009 |
| NEW YORK MEDICAL COLLEGE | $795,000 | Grant | Trans-NIH Recovery Act Research Support: A major goal of cardiac research is to develop the means to repair diseased or damaged hearts with newly generated myocardial tissue. A longstanding paradigm of cardiovascular biology was that the myocardium of the adult mammalian heart is postmitotic. | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $1,549,856 | Grant | Trans-NIH Recovery Act Research Support: Sickle cell disease (SCD) is one of the most common inherited diseases in the United States. Vasocclusion, resulting in acute, debilitating pain, is the hallmark of SCD often necessitating hospitalization. In part due to SCD patients? need for narcotic me | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION | $424,850 | Grant | Trans-NIH Recovery Act Research Support: Nanoparticles are engineered structures with dimension of 100 nanometers or smaller. Available evidence indicates that the properties of nanoparticles may substantially differ from the same composition in the micrometer scale. However, the biological ef | Health and Human Services, Department of / National Institutes of Health | 5/30/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $751,294 | Grant | Trans-NIH Recovery Act Research Support: Hibernating mammals survive without food and water for periods of time and at body temperatures that would normally evoke life-threatening cardiovascular responses in humans. During hibernation, neurons in the central nervous system (CNS), including those | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| WASHINGTON UNIVERSITY, THE | $760,000 | Grant | Trans-NIH Recovery Act Research Support: Diabetes mellitus is associated with a cardiomyopathy that occurs in the absence of hypertension or coronary artery disease and that is characterized by ventricular hypertrophy, decreased ventricular diastolic relaxation, and a reduced peak filling rate. | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $926,278 | Grant | Trans-NIH Recovery Act Research Support: The main function of the vascular endothelium is the mediation and control of the transendothelial exchanges of water and solutes (both small and large molecules) between blood plasma and the interstitial fluid, in short the control of vascular permeabili | Health and Human Services, Department of / National Institutes of Health | 9/10/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $1,435,514 | Grant | Trans-NIH Recovery Act Research Support: Genetic Determinants of Premature Vascular Dysfunction in Families: This is a study to find the genes responsible for prematurely stiff and unresponsive arteries. The study is done in families with a risk of early heart attacks. | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $918,058 | Grant | Trans-NIH Recovery Act Research Support: Lung transplants have been performed in over 20,000 individuals with advanced lung disease, with two-year survival of 70% and dramatic improvements in quality of life. However, long-term survival rates remain lower than those of kidney, heart, and liver r | Health and Human Services, Department of / National Institutes of Health | 5/30/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $1,489,651 | Grant | Trans-NIH Recovery Act Research Support: The objective of this two-year project is to improve the outcome following heart transplantation by clarifying the mechanisms involved with the induction of donor-specific tolerance via the mixed chimerism approach. Tolerance of kidney allografts in non-h | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $1,059,232 | Grant | Trans-NIH Recovery Act Research Support: Pressure overload-induced cardiac hypertrophy due to valvular or hypertensive heart diseases is one of the most common causes of congestive heart failure in the U.S. During the last decade, many efforts have been focused on the elucidation of the signalin | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| WASHINGTON UNIVERSITY, THE | $962,912 | Grant | Trans-NIH Recovery Act Research Support: Cardiovascular disease (CVD) and its associated risk factors such as hypertension and dyslipidemia constitute a major public-health burden due to increased mortality and morbidity and rising health care costs. Massive epidemiological data are needed to de | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF OKLAHOMA | $804,803 | Grant | Trans-NIH Recovery Act Research Support: Myeloproliferative disorders (MPDs) are a group of conditions characterized by chronic increases in some or all of the blood cells (platelets, white blood cells, and red blood cells). Recently, we and others have identified a mutation in the JAK2 tyrosine | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $1,429,601 | Grant | Trans-NIH Recovery Act Research Support: In the United States alone, approximately 500,000 deaths will result from rupture of plaques considered 'insignificant' on an angiographic evaluation. Available screening and diagnostic methods are insufficient to identify possible victims before the even | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $3,157,848 | Grant | Trans-NIH Recovery Act Research Support: A critical issue for disaster response is group or collaborative computing in mobile environments. This application describes research to address three critical inter-related problems that inhibit the successful use of information technologies at disaster | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF PITTSBURGH THE | $1,162,288 | Grant | Trans-NIH Recovery Act Research Support: Predicting Patient Outcomes from Clinical and Genome-Wide Data Clinical classification and prediction are key components of clinical care. Even modest improvements in classification and predictive performance may have significant healthcare consequences | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $912,461 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this proposal is to enhance the manner in which physicians access, process and marshal medical information by providing them with an automatically generated, comprehensive, and up-to date summary of the information appearing in a pat | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $1,005,690 | Grant | Trans-NIH Recovery Act Research Support: Attention-deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed behavioral disorder in children. Prevalence rates in the United States range from 2% to 18% depending on diagnostic criteria and population studied. Primary care physicians, es | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $1,432,837 | Grant | Trans-NIH Recovery Act Research Support: The function of millions of proteins remains unknown, and automated protein function prediction systems have a poor record of performance. We will test hypotheses about protein functional sites by validating high-throughput predictions derived from comput | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| DUKE UNIVERSITY | $1,439,593 | Grant | Trans-NIH Recovery Act Research Support: Abstract Recent increases in HIV diagnoses, sexually transmitted infections, and risk behavior indicate that research is needed to identify effective positive prevention interventions integrated within HIV primary care settings to reduce transmission ris | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| UNIVERSITY OF FLORIDA | $725,450 | Grant | Trans-NIH Recovery Act Research Support: Little is known about the development of abnormal repetitive behavior (e.g., stereotypies, rituals) in children at risk for autism and related neurodevelopmental disorders. This lack of knowledge precludes effective early intervention and prevention stra | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $1,163,614 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The long-range objective of the proposed research is to refine, evaluate, and disseminate an Internet-based intervention to prevent eating disorders (EDs) and comorbidities in college-age women. EDs are highly prevalen | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| EMORY UNIVERSITY | $940,333 | Grant | Trans-NIH Recovery Act Research Support: In Crisis Intervention Team (CIT) training, police officers participate in 40 hours of specialized training provided by local mental health professionals, family members/advocates, and mental health consumer groups. Upon completion, these officers serve a | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF MARYLAND | $750,000 | Grant | Trans-NIH Recovery Act Research Support: Associative learning is supported by the ability to recognize errors between expected and actual outcomes. Evidence from primate and rat recording studies suggests that dopaminergic neurons in substantia nigra and the ventral tegmental area (VTA) signal s | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| THE VANDERBILT UNIVERSITY | $1,076,797 | Grant | Trans-NIH Recovery Act Research Support: Fragile X Syndrome (FraX) is a developmental brain disorder with abnormal neuron architecture development and functional plasticity of the developing brain, causing mental retardation, learning disabilities and autism. My lab established the Drosophila F | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL | $2,393,264 | Grant | Trans-NIH Recovery Act Research Support: In this project we will apply our in-house software package KELVIN to data contained in repositories established by the NIH, leveraging publicly available data sets in order to formulate more comprehensive models of the genetic architecture of SZ and BP. | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $1,208,739 | Grant | Trans-NIH Recovery Act Research Support: We propose a partnership between expert large scale sequencing centers and a collaborative network of research labs focused on the genetics of autism to utilize novel high throughput genome sequencing to discover specific genes underlying the significant | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| BROAD INSTITUTE, INC., THE | $4,165,764 | Grant | Trans-NIH Recovery Act Research Support: This collaborative application is submitted in response to RFA MH-09-171. The root causes of autism remain unknown, limiting efforts to understand disease heterogeneity, diagnose cases, and prevent and treat disease. Epidemiological findings have repeated | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| DUKE UNIVERSITY | $780,000 | Grant | Trans-NIH Recovery Act Research Support: Understanding the mechanisms of limbic epileptogenesis may lead to novel disease modifying therapies. We have discovered that epileptogenesis is associated with enhanced activation of TrkB in the mossy fiber pathway of hippocampus. We have also discovered | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $793,510 | Grant | Trans-NIH Recovery Act Research Support: ?Redox signaling in axon guidance: Structure and activity of MICAL? During neural development, axons are guided to their final destination by a large number of molecular cues?attractive and repulsive signals that instruct the cytoskeleton to redirect the | Health and Human Services, Department of / National Institutes of Health | 6/15/2009 |
| DUKE UNIVERSITY | $780,000 | Grant | Trans-NIH Recovery Act Research Support: This project concerns the role of ectopic dentate granule cells in temporal lobe epilepsy. The dentate gyrus is believed to act as a gatekeeper or filter to inhibit the propagation of synchronized discharge through the limbic circuit. In both temporal lob | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF NEW MEXICO | $1,478,291 | Grant | Trans-NIH Recovery Act Research Support: Using Transport to Map the Brain A major challenge in understanding how the brain processes information is defining the circuitry that links neurons into a functional distributed parallel processing network. Intracellular transport is a normal biological | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $1,253,569 | Grant | Trans-NIH Recovery Act Research Support: Due to unprecedented increases in the elderly populations, age-related diseases are expected to increase exponentially in the coming years. Among these, neurodegenerative diseases will be the most devastating in terms of their emotional and economic effec | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $660,313 | Grant | Trans-NIH Recovery Act Research Support: Blood-brain barrier (BBB) disruption represents a classic hallmark of central nervous system inflammation and it occurs in a variety of neuropathological conditions. BBB disruption involves remodeling of the brain endothelial cell surface, altered distrib | Health and Human Services, Department of / National Institutes of Health | 9/20/2009 |
| CHILDRENS HOSPITAL OF PHILADELPHIA | $1,820,924 | Grant | Trans-NIH Recovery Act Research Support: This project is designed to identify genetic variants that confer susceptibility to common forms of epilepsy including i) forms of idiopathic generalized epilepsy (IGE) such as juvenile myoclonic epilepsy (JME), childhood absence epilepsy (CAE) and idiopa | Health and Human Services, Department of / National Institutes of Health | 9/20/2009 |
| WASHINGTON UNIVERSITY, THE | $850,024 | Grant | Trans-NIH Recovery Act Research Support: One of the pathological hallmarks of Alzheimer's Disease (AD) is the senile plaque, principally composed of the Abeta peptide. Abeta1-42, the 42 amino-acid peptide fragment of the amyloid precursor protein (APP), has a striking propensity to aggregate int | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| UNIVERSITY OF PITTSBURGH THE | $1,514,238 | Grant | Trans-NIH Recovery Act Research Support: We reported on a limited number of cases that SIVagm infection is completely controlled in rhesus macaques (RMs). Our preliminary results showed that although acute SIVagm infection in RMs is characterized by: high levels of viral replication, and dramati | Health and Human Services, Department of / National Institutes of Health | 9/26/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $125,118 | Grant | Trans-NIH Recovery Act Research Support: A central issue in the study of mortality and health at the older ages is the long term effect of early childhood health. This is especially important given that there have been very rapid declines in mortality at the oldest ages which can not be adequate | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| UNIVERSITY OF KENTUCKY | $121,702 | Grant | Trans-NIH Recovery Act Research Support: It is well established that cardiac contractile reserve declines while the incidence of heart failure increases dramatically with age. According to the free radical theory of aging, cardiac dysfunction may be the result of oxidative stress-induced myocard | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| MISSOURI SYSTEM, UNIVERSITY OF | $144,550 | Grant | Trans-NIH Recovery Act Research Support: We are investigating the role of FoxP3 transcription factor in the development of T regulatory cells. More precisely, we are analyzing whether FoxP3 interacts with c-jun or c-Fos to sustain development of Tregs. | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| UNIVERSITY OF ARIZONA | $151,209 | Grant | Trans-NIH Recovery Act Research Support: Triatomine bugs, commonly known as kissing bugs, vinchuca, chipo, barbeiro, are blood-sucking insects, vectors of the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas Disease. This Disease is endemic in Mexico, Central and South America | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| UNIVERSITY OF PITTSBURGH THE | $167,226 | Grant | Trans-NIH Recovery Act Research Support: Escherichia coli that produces extended-spectrum beta-lactamase (ESBL) tends to be resistant to many classes of antibiotics. Spread of these multidrug-resistant strains of E. coli in the community may lead to treatment failures of common infections such a | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| L2 DIAGNOSTICS LLC | $182,436 | Grant | Trans-NIH Recovery Act Research Support: The mammalian innate immunity is the first line of the host defense against invading pathogens including viruses. Within the host, antigen-presenting cells such as dendritic cells and macrophages, express a variety of pattern recognition receptors (PRRs) | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF SOUTH FLORIDA | $143,949 | Grant | Trans-NIH Recovery Act Research Support: The study of viral dynamics is one of the most important developments in recent HIV/AIDS research for understanding HIV pathogenesis and antiretroviral (ARV) therapies. However, most studies focused on short-term viral dynamics, and the models therein may | Health and Human Services, Department of / National Institutes of Health | 5/11/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $148,500 | Grant | Trans-NIH Recovery Act Research Support: This project is being supported with funds from the American Recovery and Reinvestment Act, which may involve a reduction in the research aims and scope. If necessary, a revised abstract will be posted soon and this notice removed. DESCRIPTION (provided | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $153,680 | Grant | Trans-NIH Recovery Act Research Support: Gammaherpesviruses cause lifelong infection and are associated with various diseases, particularly in immune deficient hosts. The human gammaherpesviruses, Epstein Barr virus (EBV) and Kaposi's sarcoma associated virus, are associated with a number of mal | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $146,417 | Grant | Trans-NIH Recovery Act Research Support: Complement is important part of the innate immune system and is arguably best known for its ability to lyse bacteria, enveloped viruses and eukaryotic cells through a macro-molecular structure known as the membrane attack complex (MAC). The MAC is compos | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF MARYLAND | $150,000 | Grant | Trans-NIH Recovery Act Research Support: Highly active antiretroviral therapy (HAART) has dramatically increased life expectancy in HIV infection and by 2015 more than half of HIV patients in the U.S. will be older than 50. Elderly HIV patients often experience comorbidities such as neuropsychia | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| AKRON GENERAL MEDICAL CENTER | $149,000 | Grant | Trans-NIH Recovery Act Research Support: Computational and Experimental Analysis of Tibial Tuberosity Transfers | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $155,100 | Grant | Trans-NIH Recovery Act Research Support: The normal remodeling of bone requires synchronized activity between bone resorbing osteoclastic and bone forming osteoblastic cells. This synchronization includes the recruitment of osteoblasts and osteoclasts, and the stimulation of osteoclast and osteo | Health and Human Services, Department of / National Institutes of Health | 8/07/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $154,386 | Grant | Trans-NIH Recovery Act Research Support: The Overall objective of the project is to develop mechanism based iNOS / PI3 kinase inhibitor in addition to selenium to increase potency against colon cancer prevention. Several iNOS inhibitors have been reported for prevention of cancers. One such agen | Health and Human Services, Department of / National Institutes of Health | 6/09/2009 |
| HEALTH RESEARCH, INC. | $119,923 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Breast cancer is the most common cancer in US women. Environmental and dietary genotoxicants are believed to play a role in women's cancer risk; however, the Long Island Cohort Study failed to find a direct connection | Health and Human Services, Department of / National Institutes of Health | 5/28/2009 |
| UNIVERSITY OF OKLAHOMA | $146,445 | Grant | Trans-NIH Recovery Act Research Support: This study involves conducting secondary analyses of the five waves of longitudinal data from the Youth Asset Study (YAS). The data collection ended in December 2008. The study population consists of 1,117 teen/parent pairs survey participants randomly se | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $378,750 | Grant | Trans-NIH Recovery Act Research Support: Opioid-induced glial activation, which compromises pain treatment and contributes to the development of drug addiction and abuse, is regulated via a signaling pathway downstream of toll-like receptor-4 (TLR4), a membrane spanning receptor that functions i | Health and Human Services, Department of / National Institutes of Health | 5/04/2009 |
| RFCUNY - HUNTER COLLEGE | $406,791 | Grant | Trans-NIH Recovery Act Research Support: ARRA - TRANS-NIH RECOVERY ACT RESEARCH SUPPORT - MDMA (G?EcstasyG?) is a popular drug of abuse especially among youth in the population. Use of MDMA is associated with acute physiological effects among which is the development of hyperthermia, which in tu | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $154,500 | Grant | Trans-NIH Recovery Act Research Support: Abstract Dopaminergic transmission in the synapse is primarily terminated by removal of dopamine (DA) into presynaptic nerve terminals via the dopamine transporter (DAT), one of a superfamily of Na+/Cl--dependent neurotransmitter transporters. DAT is a ma | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF ILLINOIS | $311,150 | Grant | Trans-NIH Recovery Act Research Support: Breakdown in decision making and propensity for risk taking are common features of drug addiction that contribute in part to increased rates of unsafe sexual and drug using practices. Compelling evidence demonstrates that HIV+ drug users are more vulnerab | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| DUKE UNIVERSITY | $234,000 | Grant | Trans-NIH Recovery Act Research Support: Cigarette smoking remains the number one preventable cause of premature death in the U.S. In spite of these avoidable consequences, an estimated 60-90% of smokers motivated to attempt to quit relapse within the first year of their attempt. Research sugges | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $309,000 | Grant | Trans-NIH Recovery Act Research Support: Opiate drug abuse and human immunodeficiency virus (HIV) infection/AIDS are two major public health problems. HIV-associated sensory neuropathy (HIV-SN) is the most common neurological complication of HIV infection. The symptoms of HIV-SN are dominated by | Health and Human Services, Department of / National Institutes of Health | 5/04/2009 |
| UNIVERSITY OF MARYLAND | $290,986 | Grant | Trans-NIH Recovery Act Research Support: Despite significant advances in the understanding of the caries process and in the interventions needed to prevent it, early childhood caries (ECC) remains one of the most prevalent diseases among children in the United States and the world. The main obje | Health and Human Services, Department of / National Institutes of Health | 4/29/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $146,447 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION: Spinal cord injury (SCI) leads to a profound reduction in physical activity, resulting in a low exercise capacity and increased risk of mortality. Of note, physical inactivity is approaching tobacco as the leading actual cause of death in the | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| WESTAT, INC. | $182,603 | Grant | Trans-NIH Recovery Act Research Support: Westat is conducting this study to validate a new measure of social information processing. In the first phase, conducted in 2009-2010, parents with children in preschool and kindergarten from a charter school were invited to participate in the study. D | Health and Human Services, Department of / National Institutes of Health | 9/10/2009 |
| EAST CAROLINA UNIVERSITY | $143,500 | Grant | Trans-NIH Recovery Act Research Support: The central hypothesis to be tested in this application is that TLRR (also known as lrrc67), a recently identified testis-specific protein, functions to localize signaling molecules, including protein phosphatase-1 (PP1), near the nucleus of male germ cel | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| RAND CORPORATION, THE | $190,206 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Subjective expectations are an important determinant of health-related behaviors in developing country contexts as individuals face substantial uncertainty about their own and other family members' health, the relation | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| MAYO CLINIC | $150,801 | Grant | Trans-NIH Recovery Act Research Support: Autosomal recessive polycystic kidney disease (ARPKD) is an important genetic disorder in pediatric practice. ARPKD is a renal and hepatic disease in neonates and infants, and <30% of affected neonates die because of greatly enlarged kidneys detected in | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $147,500 | Grant | Trans-NIH Recovery Act Research Support: SIGNIFICANCE: In the United States, it is estimated that one in seven women will develop breast cancer during their lifetime. Estrogens are an important risk factor for the disease. The timing of exposure also plays an important role in the determinatio | Health and Human Services, Department of / National Institutes of Health | 8/26/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $169,500 | Grant | Trans-NIH Recovery Act Research Support: Prematurity, enteral formula feeding, and bacterial colonization are three major risk factors for neonatal necrotizing enterocolitis (NEC). The hallmark pathologic findings in NEC are intestinal mucosal injuries. However, the etiology and pathogenesis of | Health and Human Services, Department of / National Institutes of Health | 4/29/2009 |
| SYRACUSE UNIVERSITY | $130,343 | Grant | Trans-NIH Recovery Act Research Support: Early research on the consequences of teenage childbearing showed that both teen mothers and their offspring are disadvantaged relative to women (and their children) who delay their fertility. Based on this research, policymakers have responded by making | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| WAYNE STATE UNIVERSITY (INC) | $152,000 | Grant | Trans-NIH Recovery Act Research Support: To research how AMP-activated protein kinase management will improve oocyte cryopreservation. | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| NORTH CAROLINA STATE UNIVERSITY | $148,959 | Grant | Trans-NIH Recovery Act Research Support: Early events in the pathogenesis of interstitial pulmonary fibrosis (IPF) have been linked to faulty repair of injured alveolar epithelium where proliferating alveolar type II (AT2) cells do not effectively differentiate into type I (AT1) cells. This lea | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| UNIVERSITY OF WASHINGTON | $154,949 | Grant | Trans-NIH Recovery Act Research Support: We discovered mutations in the Senataxin gene (SETX) as the molecular basis of a juvenile-onset, autosomal dominant (AD) form of familial amyotrophic lateral sclerosis (ALS). This form of ALS, known as ALS4, is an essentially pure motor systems disorder c | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| UNIVERSITY OF PUERTO RICO | $149,000 | Grant | Trans-NIH Recovery Act Research Support: Gene profiling of nervous system regeneration using a novel model organism Post-traumatic regeneration of neurons and fibers in the mammalian spinal cord has not been plausible, even though extensive studies have been made to understand the restrictive fa | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $176,792 | Grant | Trans-NIH Recovery Act Research Support: Chordomas are rare, slow-growing, malignant sarcomas that originate from notochordal remnants along the axial skeleton. Molecular mechanism of chordoma development remains unknown. Intriguingly, tuberous sclerosis complex (TSC) is the only known syndrome | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| BRIGHAM YOUNG UNIVERSITY | $224,523 | Grant | Trans-NIH Recovery Act Research Support: Non-enveloped viruses breach the formidable cell membrane and deposit their infectious nucleic acid in the appropriate cellular compartment, a process known as 'cell entry.' Mechanisms of entry for non-enveloped viruses are not well understood, though ani | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF OKLAHOMA | $219,750 | Grant | Trans-NIH Recovery Act Research Support: Dental caries and periodontal diseases are typical polymicrobial diseases, in which the pathogen(s) is also a member of the normal flora, which becomes pathogenic when the ecological balance of the commensal and pathogen is shifted toward overgrowth of th | Health and Human Services, Department of / National Institutes of Health | 8/21/2009 |
| MIAMI UNIVERSITY | $213,000 | Grant | Trans-NIH Recovery Act Research Support: Electrochemically assisted sol-gel processing provides a route to deposit silica films with thicknesses in the range 10-200 nm, on electrodes. These films are non-conductive and therefore passivate the electrode. To impart conductivity we will either te | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF TEXAS AT SAN ANTONIO | $397,375 | Grant | Trans-NIH Recovery Act Research Support: Candidiasis now represents the third most frequent nonsocomial infection in hospitals both in the US and worldwide, and C. albicans remains the most frequent causative agent of cadidiasis. Unfortunately these infections carry unacceptably high mortality | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| THE GEORGE WASHINGTON UNIVERSITY | $346,500 | Grant | Trans-NIH Recovery Act Research Support: Rationale: Hepatic Scavenger Receptor Class B, Type I receptor (SRBI), a highly glycosylated 82 kDa protein, is primarily responsible for hepatic cholesterol ester uptake from high density lipoproteins (HDL), a process termed Reverse Cholesterol Transport | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| UNIVERSITY OF WASHINGTON | $339,275 | Grant | Trans-NIH Recovery Act Research Support: Heavy episodic drinking (HED) among college students is a persistent public health problem with severe consequences, including development of substance-use disorders, psychosocial problems, health risks, accidental injuries, and death. National US survey | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $348,398 | Grant | Trans-NIH Recovery Act Research Support: This application requests R21 exploratory funds to develop methodology and tools leading to a comprehensive registry of biomarker and health variables found in publicly available secondary data collections. The proposed pilot will begin with data drawn fr | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF IOWA, THE | $333,330 | Grant | Trans-NIH Recovery Act Research Support: In many age-related neurodegenerative diseases, neuronal loss is correlated with the presence of hyperphosphorylated tau. In Alzheimer's disease, it has been hypothesized that neurons die because cell cycle mechanisms have been activated. In support of th | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $360,472 | Grant | Trans-NIH Recovery Act Research Support: A major cause of morbidity and mortality in the aged is infections, including common viral infections such as influenza and respiratory syncytial virus (RSV), that the immune system of healthy young individuals has little difficulty combating. While there | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| WAKE FOREST UNIVERSITY | $360,894 | Grant | Trans-NIH Recovery Act Research Support: Aging is accompanied by a decline in immune responsiveness that renders older adults highly susceptible to infectious diseases, and immunization vs. vaccine preventable illness such as influenza is less effective in seniors. A recently identified, vaccine | Health and Human Services, Department of / National Institutes of Health | 5/20/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $287,028 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION: An emphasis in recent Alzheimer's disease (AD) research is identifying features and avenues for early intervention in the preclinical state of AD. Advanced imaging methods that enable visualization of AD associated brain changes at an early | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| NORTH CAROLINA STATE UNIVERSITY | $397,633 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this R21 application is to explore the feasibility of using bacteriophage resistance as a feature of a live, attenuated, oral Listeria monocytogenes vaccine delivery platform. We are studying a phage resistant mutant in which a Tn917 insert | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| WAKE FOREST UNIVERSITY | $407,000 | Grant | Trans-NIH Recovery Act Research Support: Systemic lupus erythematosus (SLE, lupus) is a complex systemic autoimmune disease characterized by various immunological abnormalities, including an imbalance between type 1 and type 2 T cells that contributes to skewed cytokine production. The initial s | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $469,000 | Grant | Trans-NIH Recovery Act Research Support: While most acute infectious diarrheas are self-limited, a subset requires aggressive treatment in order to minimize complications and/or prevent spread. Upon presentation, it is virtually impossible to know whether a diarrheal illness will have a progress | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| WAYNE STATE UNIVERSITY (INC) | $418,000 | Grant | Trans-NIH Recovery Act Research Support: Interleukin 13 (IL-13) is a pleiotropic, anti-inflammatory cytokine produced mainly by activated Th2 T cells. We have recently cloned a naturally occurring mRNA splice variant of IL-13 in which the second exon is omitted (termed IL-13?E2). Our characteriz | Health and Human Services, Department of / National Institutes of Health | 6/19/2009 |
| UNIVERSITY OF WASHINGTON | $428,999 | Grant | Trans-NIH Recovery Act Research Support: Mycoplasma genitalium is a newly recognized cause of reproductive tract disease syndromes, including urethritis, mucopurulent cervicitis, pelvic inflammatory disease, endometritis, preterm birth, with possible sequelae that include infertility, chronic pe | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| OAK CREST INSTITUTE OF SCIENCE | $411,425 | Grant | Trans-NIH Recovery Act Research Support: The broad long term goal of this project is to empower women to protect themselves from HIV infection through the development of improved microbicides based on sustained release drug delivery. Each day 15,000 people are infected - a growing majority of th | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $401,218 | Grant | Trans-NIH Recovery Act Research Support: Pathogenesis of HCV in a Novel Mouse Model - ARRA All current mouse models allow only HCV replication in the absence of a functional immune system. Those models are not useful to study host immune responses, their contributions to HCV pathogenesis and pot | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| DUKE UNIVERSITY | $429,000 | Grant | Trans-NIH Recovery Act Research Support: Cytokines produced by CD4+ T lymphocytes play essential roles in host adaptive immune responses and are involved in the development of allergic diseases including asthma. Our understanding of the pathways regulating cytokine production in CD4+ T lymphocyt | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $400,000 | Grant | Trans-NIH Recovery Act Research Support: The high prevalence of nosocomial infections by multidrug-resistant Enterococcus faecalis presents both a treatment and an infection control challenge in the hospital setting. There is a clear demand to control enterococcal multi-drug resistance problems | Health and Human Services, Department of / National Institutes of Health | 6/17/2009 |
| THE GEORGE WASHINGTON UNIVERSITY | $234,500 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of our research is to understand how the RNAi mechanism affects HIV-1 viral replication. RNA interference (RNAi) is a regulatory mechanism conserved in higher eukaryotes. The RNAi pathway generates small interfering RNA (siRNA) or micr | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $513,235 | Grant | Trans-NIH Recovery Act Research Support: This proposal is to study the biological significance of IgE isoforms in allergic disorders. IgE plays.a major role in allergic disorders, including asthma, atopic dermatitis. We focus on a specific form of IgE believed to be responsible for allergic s | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $431,600 | Grant | Trans-NIH Recovery Act Research Support: A novel approach is proposed to develop a cholera subunit vaccine based on the current understanding of Vibrio cholerae (Vc) colonization, pathogenesis, and the human immune response to cholera. Currently, a killed, whole-cell (W-C) Vc vaccine delivered o | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON | $412,500 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The growing pandemic of type 2 diabetes (DM) is being increasingly recognized as a threat to tuberculosis (TB) control. Epidemiological studies consistently show DM patients are more susceptible to TB, but the underlyi | Health and Human Services, Department of / National Institutes of Health | 7/30/2009 |
| NORTHWESTERN UNIVERSITY | $407,667 | Grant | Trans-NIH Recovery Act Research Support: A suite of synchrotron-based x-ray imaging methodologies will be used to assess the development of crystalline biofilms formed by Proteus mirabilis in urinary catheters. Proteus is an extremely common pathogen in urinary tract infections, and is particula | Health and Human Services, Department of / National Institutes of Health | 5/28/2009 |
| UNIVERSITY OF MARYLAND | $224,486 | Grant | Trans-NIH Recovery Act Research Support: The hepatitis C virus (HCV) is an important pathogen that has infected approximately 170 million people worldwide. In spite of extensive efforts, surprisingly little is known about the mechanism by which HCV initiates infection. The lack of vaccine or eff | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $903,087 | Grant | Trans-NIH Recovery Act Research Support: The development of a safe and effective topical microbicide to prevent the sexual transmission of HIV could playa major role in worldwide reduction of the over 14,000 new HIV infections per day, and potentially save millions of lives. The goal of this pro | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) | $429,000 | Grant | Trans-NIH Recovery Act Research Support: Aggregatibater (Actinobacillus) actinomycetemcomitans is the etiologic agent of localized aggressive periodontitis and other systemic infections including infective endocarditis. A. actinomycetemcomitans produces an RTX toxin, leukotoxin (LtxA), specific | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| SEATTLE BIOMEDICAL RESEARCH INSTITUTE | $434,268 | Grant | Trans-NIH Recovery Act Research Support: Many important diseases, including malaria, hepatitis and AIDS, could be eliminated by successful vaccines. However, such vaccines are elusive. This project aims to develop a new approach to making vaccines more effective. Our research has revealed an une | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $450,009 | Grant | Trans-NIH Recovery Act Research Support: Our central hypothesis is that the interaction between HIV-1 integrase (IN) and the cellular co-factor LEDGF/p75 is important for efficient viral replication. We further hypothesize that inhibitors of this interaction have antiviral activity, a low chance | Health and Human Services, Department of / National Institutes of Health | 7/23/2009 |
| COLORADO STATE UNIVERSITY | $398,863 | Grant | Trans-NIH Recovery Act Research Support: In the early stages of Mycobacterium tuberculosis (Mtb) infection, irreversible tissue necrosis occurs as the result of localized lung inflammation. The bactericidal mechanism of macrophages and neutrophils, that are supposed to control the infection, in | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE | $423,500 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Leishmania spp. are favorably considered as a universal carrier for vaccine delivery, since they have evolved not only an innate ability to infect antigen-presenting cells (APC) but also to reside exclusively in the an | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| TEXAS ENGINEERING EXPERIMENT STATION | $362,504 | Grant | Trans-NIH Recovery Act Research Support: Hepatitis C virus (HCV) infection is a major public health problem, putting infected individuals (~180 million worldwide) at risk of developing cirrhosis, hepatocellular carcinoma, and liver failure. Chronic hepatitis C is the leading cause for liver tran | Health and Human Services, Department of / National Institutes of Health | 7/30/2009 |
| CHILDREN'S RESEARCH INSTITUTE | $473,000 | Grant | Trans-NIH Recovery Act Research Support: Chronic rhinosinusitis (CRS) is one of the most prevalent chronic diseases in the USA but its pathophysiology is not well understood. Proinflammatory mediators and immunoreactive products likely play a significant role in initiating and sustaining the inf | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $392,500 | Grant | Trans-NIH Recovery Act Research Support: Basic biomedical research to understand the function of T lymphocytes. These are the central regulatory cell of the immune system, the part of our body that fights off viruses, pathogenic bacteria, and parasites. The grant is entitled 'A quantitative unde | Health and Human Services, Department of / National Institutes of Health | 6/19/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $434,500 | Grant | Trans-NIH Recovery Act Research Support: Toxoplasma gondii is an important opportunistic infection of AIDS patients. Improved strategies and approaches are urgently needed to more effectively prevent and treat recurrent opportunistic infections in AIDS. Toxoplasma gondii is also being increasing | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| COLD SPRING HARBOR LABORATORY | $9,869 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this application is to understand biochemical mechanisms that underlie the function of rhesus monkey TRIM5 (rhTRIM5). rhTRIM5 blocks HIV-1 infection by acting at two or more post-entry stages. Importantly, rhTRIM5 E3 ubiquitin ligase a | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $381,150 | Grant | Trans-NIH Recovery Act Research Support: Fibromyalgia (FM) is a pain disorder defined by chronic widespread pain and multiple muscle-tendon junction tender points. Exercise has been suggested as a treatment for FM. Several exercise interventions in FM have demonstrated that patients who can tole | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $379,397 | Grant | Trans-NIH Recovery Act Research Support: Atherosclerotic cardiovascular disease is the main cause of the long observed early mortality in rheumatoid arthritis (RA) patients. In this project, the possibility that the RA shared epitope (SE) is directly contributing to atherosclerosis development w | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| NEMOURS FOUNDATION, THE | $432,999 | Grant | Trans-NIH Recovery Act Research Support: The primary goal of this COBRE proposal is to increase the number of active, NIH-funded biomedical researchers in the State of Delaware. This will be accomplished through the efforts of a multidisciplinary group of investigators at the Nemours Research In | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| MARSHALL UNIVERSITY RESEARCH CORPORATION | $490,224 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this supplement request is to expose undergraduate minority students to research being conducted on cancer, including transcription factors, nutrition and cancer, as well as genomics and cancer. Selected students will be piggy-backed onto | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| MONTANA STATE UNIVERSITY, INC | $996,025 | Grant | Trans-NIH Recovery Act Research Support: This project seeks to strengthen research collaborations between Montana State University and clinicians affiliated with the University of Washington Institute of Translational Health Sciences and to advance effective means to conduct systems biology-base | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $124,759 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The specific Aims of the Nathan Shock Center (NSC) at the University of Michigan (UM) are to: (i) facilitate and stimulate research programs in the cellular and molecular biology of aging; (ii) encourage the career dev | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $291,000 | Grant | Trans-NIH Recovery Act Research Support: We request an administrative supplement to our grant P30 AG017253 to augment our research on the trends in demography, economics, health and healthcare of the aging. This administrative supplement will enable expanding the approaches used in our existing | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $338,178 | Grant | Trans-NIH Recovery Act Research Support: Dana Farber/Harvard Cancer Center (DF/HCC) is an inter-institutional research enterprise that unites the major clinical, population, and basic cancer research efforts of the Harvard medical and public health community. It was founded in 1998 through a for | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | $3,625,922 | Grant | Trans-NIH Recovery Act Research Support: Memorial Sloan-Kettering Cancer Center is requesting 2 years of support for the recruitment of physician-scientists; one in the areas of translational oncology, who will be appointed to our Human Oncology and Pathogenesis Program (HOPP), and one in the De | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $49,994 | Grant | Trans-NIH Recovery Act Research Support: Our Cancer Center agrees to participate in the planning activities associated with the project entitled ADOPTion of New Technologies for Remote Data Capture and Protocol Authoring (ADOPT) by providing appropriate clinical and informatics expertise in s | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $138,561 | Grant | Trans-NIH Recovery Act Research Support: The goal of this proposal is to introduce high school and undergraduate students from all segments of the population to state-of-the-art cancer research and encourage the pursuit of cancer research as a career. This is the best way to increase the pipeli | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $1,586,953 | Grant | Trans-NIH Recovery Act Research Support: To recruit a new faculty member to enhance the acute myeloid leukemia research program in the area of leukemia stem cell biology and targeted therapeutics. | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $1,461,630 | Grant | Trans-NIH Recovery Act Research Support: This supplement was awarded to provide research support for a newly recruited physician scientist. This new faculty member has the primary goal of establishing a translational research program that will lead the way in developing new therapeutic strate | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $50,000 | Grant | Trans-NIH Recovery Act Research Support: The Cancer Center will participate in planning activities associated with project ADOPT by providing the clinical and informatics expertise of two staff members in scheduled meetings and conference calls for the duration of the project period. | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $47,976 | Grant | Trans-NIH Recovery Act Research Support: The University of Minnesota Cancer Center (UMCC) is a NCI-designated Comprehensive Cancer Center dedicated to cancer research, education, and patient care for the citizens of the state of Minnesota and surrounding region. Since the time of the first award | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF NEW MEXICO | $50,168 | Grant | Trans-NIH Recovery Act Research Support: The Cancer Epidemiology and Prevention Program was formally established in 1973 when the New Mexico Tumor Registry joined with 6 other population-based tumor registries to form the NCI-SEER (Surveillance, Epidemiology and End Results) program. The NM SEER | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| HUGO W. MOSER RESEARCH INSTITUTE AT KENNEDY KRIEGER, INC. | $97,651 | Grant | Trans-NIH Recovery Act Research Support: Supplemental funds for equipment purchases are requested to increase the tempo of scientific research funded under our parent grant, P30HD024061 which supports the Intellectual and Developmental Disabilities Research Center (IDDRC) of the Kennedy Krieger | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| CHILDREN'S RESEARCH INSTITUTE | $101,165 | Grant | Trans-NIH Recovery Act Research Support: Project Description (3830 characters with spaces) The project provides further support for 3 Cores of our Intellectual and Developmental Disabilities Research Center (IDDRC). The usage of the Cellular Imaging, Molecular Genetics and Neuroimaging Cores has | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $1,043,591 | Grant | Trans-NIH Recovery Act Research Support: The supplement has funded the establishment of an SIV/Macaque Research Core which will provide the expertise to evaluate novel therapeutics and surrogate markers to develop new therapies for HIV-associated neurocognitive disorders. The investigators have | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $385,314 | Grant | Trans-NIH Recovery Act Research Support: We have made significant progress towards Aim 1. In particular, we have tested the hypothesis that CtIP could physically interact with the Mre11-Rad50-Nbs1 complex. Using cell-free extracts that are virtually devoid of DNA, we immunoprecipitated Mre11 usi | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF PUERTO RICO-MEDICAL SCIENCES CAMPUS | $110,423 | Grant | Trans-NIH Recovery Act Research Support: The principal goal of this application is to use the integrated units of the CPRC to provide science educators and their students the opportunity to engage in basic biomedical and behavioral research using the resources of the CPRC. This will provided th | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $249,620 | Grant | Trans-NIH Recovery Act Research Support: In this application, we propose a comprehensive National Gene Vector Repository (NGVB) which meets all the goals stated in RFA-RR-07-002.The Specific Aims of the NGVB are: Specific Aim 1. Develop and Oversee a Repository of Gene Therapy Reagents. The NGVB | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $208,386 | Grant | Trans-NIH Recovery Act Research Support: This Resource develops and uses Multi-isotope Imaging Mass Spectrometry (MIMS), the combination of a novel type of secondary ion mass spectrometer with tracer methods and intensive quantitative image analysis. MIMS provides high mass separation (M/deltaM | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| THE JACKSON LABORATORY | $1,038,804 | Grant | Trans-NIH Recovery Act Research Support: We will provide for the research community a classification and representation of cell types. We will refine the terminology for cell types, and provide logical definitions for all terms. This project will extend the ability of biologists to standardize | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| THE WASHINGTON UNIVERSITY | $40,166 | Grant | Trans-NIH Recovery Act Research Support: Mass spectrometry has become the enabling tool for identification of both lipids and proteins and fordetermination of their structures and properties. The changes in lipids with disease have becomeincreasingly recognized, suggesting they may be biomarkers | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $300,592 | Grant | Trans-NIH Recovery Act Research Support: Fast and reliable intra-operative diagnosis is a critical component of successful oncological surgery in a variety of organ systems. While optical probe and in vivo imaging strategies have been proposed by us and others as potential tools for surgical mar | Health and Human Services, Department of / National Institutes of Health | 8/30/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $296,866 | Grant | Trans-NIH Recovery Act Research Support: The original P41 established the NCRR Integrated Technology Resource for Biomedical Glycomics at the University of Georgia to develop and implement new technologies to investigate the glycome of cells and exploit the use of these technologies to develop e | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF KENTUCKY | $153,110 | Grant | Trans-NIH Recovery Act Research Support: The University of Kentucky is unique among land grant universities in that all colleges, including Medicine and Agriculture, are located on the same campus. This constellation of programs has enabled the UK-SBRP to develop uniquely productive collaboratio | Health and Human Services, Department of / National Institutes of Health | 8/07/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $218,991 | Grant | Trans-NIH Recovery Act Research Support: This supplemental funding will provide support for a collaboration between Boston University's Superfund Basic Research Program Outreach Core and Brown University. The Boston University Superfund Research Program is an interdisciplinary program that condu | Health and Human Services, Department of / National Institutes of Health | 9/06/2009 |
| HEALTH RESEARCH, INC. | $178,718 | Grant | Trans-NIH Recovery Act Research Support: This funding will allow us to promote job creation and economic development as it accelerates the pace and achievement of the scientific research as outlined in our parent grant, one of the seven NIH-funded Transdisciplinary Tobacco Use Research Centers ( | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF CHICAGO, THE | $363,623 | Grant | Trans-NIH Recovery Act Research Support: The Centers for Population Health and Health Disparities (CPHHD) were funded by NIH in 2003 to address social, behavioral, and biological/genetic determinants of health disparities. The eight centers collaborated previously on a joint project (supplement | Health and Human Services, Department of / National Institutes of Health | 9/06/2009 |
| UNIVERSITY OF WASHINGTON | $83,031 | Grant | Trans-NIH Recovery Act Research Support: We are particularly enthusiastic about the unique opportunity with this administrative supplement to both retain jobs and advance the tempo of our scientific research within the University of Washington NIEHS/NSF funded Pacific Northwest Center for Human | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $228,516 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement will support ongoing research undertaken by Dr. Elba Serrano's NMSU team of students and professional scientists as part of the current Cell Decision Process award. The long term goal of this research is to uncover and mode | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $235,369 | Grant | Trans-NIH Recovery Act Research Support: The Colorado Learning and Disablities Research Center (CLDRC) consists of an Administrative Cores and Five Component Projects that focus on the identification, characterization, validation and amelioration of reading disabilities (RD) and ADHD, the two m | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| MCLEAN HOSPITAL CORPORATION, THE | $128,976 | Grant | Trans-NIH Recovery Act Research Support: This is an amended competitive continuation grant of the Udall Parkinson's Disease Research Center of Excellence at Harvard University and McLean Hospital, which is directed by Professor Ole Isacson. The Center performs scientific work on conceptually nov | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON | $1,096,944 | Grant | Trans-NIH Recovery Act Research Support: Argatroban, a thrombin inhibitor, has been studied in the setting of both coronary perfusion as well as acute ischemic stroke. Since the majority of ischemic stroke patients may not benefit from rt-PA alone, the combination of thrombolytics with anticoagu | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $137,748 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this administrative supplement is 3-fold: 1) to increase access for our acute stroke patients, 2) to accelerate scientific discovery in 3 internal SPOTRIAS and 3 consortium-wide SPOTRIAS clinical research studies. 3) to stimulate the eco | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $398,887 | Grant | Trans-NIH Recovery Act Research Support: This is a Pilot Project Fund from which funding is targeted toward junior faculty at the Instructor and Assistant Professor levels. The aims of the program are to: 1) accelerate the acquisition of critical proof-of-concept data; 2) provide a valuable mean | Health and Human Services, Department of / National Institutes of Health | 10/08/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $181,500 | Grant | Trans-NIH Recovery Act Research Support: The transition from being a scientist 'in training' to being an independent researcher is typically a difficult one. We are proposing to add depth to our existing Pilot Research Program by targeting postdoctoral researchers who would normally not be elig | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $142,000 | Grant | Trans-NIH Recovery Act Research Support: During this last funding period, the ARC Laboratory Core has developed a state-of-the-art FACS facility. In addition to our previously existing FACSCalibur flow cytometer, the Core acquired 3 top model FACS pieces of equipment. These new additions of th | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| WHITEHEAD INSTITUTE FOR BIO-MEDICAL RESEARCH | $8,190 | Grant | Trans-NIH Recovery Act Research Support: Previous research published in this laboratory in Cell in 2008 (McAllister, SS et al., Cell 133:994-1005) described a process that was termed G?systemic instigationG? in which a vigorously growing G?instigatingG? tumor implanted in one side of a mouse was | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $118,696 | Grant | Trans-NIH Recovery Act Research Support: Virus-specific-CD8+ T cells play a central role in the control of viral infections by direct elimination of infected cells and secretion of a number of soluble factors. However despite the induction of strong and broad HIVspecific CD8+ T cell responses in | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $42,085 | Grant | Trans-NIH Recovery Act Research Support: Research project: In vertebrates, sensory neurons of the parasympathetic epibranchial (EB) ganglia derived from ectodermal placodes are essential for the formation of cranial sensory systems such as smell, somatosensation, and taste. Despite their importa | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $341,418 | Grant | Trans-NIH Recovery Act Research Support: This is an application for competitive revision of the currently active RO1 grant Short-Chain Dehydrogenases (SDRs) in Retinol/Sterol Metabolism submitted in response to the Notice NOT-OD-09-058: NIH Announces the Availability of Recovery Act Funds for Co | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| NORTHWESTERN UNIVERSITY | $41,723 | Grant | Trans-NIH Recovery Act Research Support: The purpose of the supplemental funds is to purchase an automated fear-conditioning system and place it within our laboratory space where we can have access to it, just like the other behavioral equipment. This purchase would be an investment in scientif | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $264,975 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this supplement to R01AA014356 is to develop and test the remote telephone delivery of a successful intervention that reduces drinking and improves contraception among women at risk for alcohol-exposed pregnancy due to frequent or bing | Health and Human Services, Department of / National Institutes of Health | 8/15/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $10,828 | Grant | Trans-NIH Recovery Act Research Support: The neurochemical and cellular mechanisms that contribute to the control of ethanol drinking behavior are not fully understood, but the involvement of dopamine in the mesolimbic system has been hypothesized for some time. Many neurochemical systems are kn | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL | $61,920 | Grant | Trans-NIH Recovery Act Research Support: Administrative Supplement Notice for Students and Science Educators under the Recovery Act; NOT-OD-09-060. The purpose of this award is to support a middle school teacher, Todd Martin, during temporary employment during the summer months with the intent | Health and Human Services, Department of / National Institutes of Health | 7/10/2009 |
| LOYOLA UNIVERSITY | $22,114 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of the proposed studies is to delineate a mechanism responsible for impaired intestinal immunity and barrier function following EtOH intoxication and burn injury. This administrative supplement award is to generate new summer jobs in adva | Health and Human Services, Department of / National Institutes of Health | 6/22/2009 |
| UNIVERSITY OF TEXAS M.D. ANDERSON CANCER CENTER, THE | $18,086 | Grant | Trans-NIH Recovery Act Research Support: Critical issues for improving the treatment of alcoholism are what neurobiological changes are responsible for the transition from non-dependent alcohol use to alcoholism, and what persistent changes mediate relapse. The goals of the present proposal are | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $70,276 | Grant | Trans-NIH Recovery Act Research Support: Neuroanatomical alterations in Alzheimer disease. Alzheimer disease (AD) dementia affects 1 in 10 American families, and costs more than 90 billion dollars a year. Genetic and neuropathological evidence highlight a pathogenic role for Abeta, but the exact | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| CHILDRENS HOSPITAL OF PHILADELPHIA | $640,558 | Grant | Trans-NIH Recovery Act Research Support: The parent grant continues to have three aims. The first is to elucidate how the molecular chaperones BiP and GRP94 react to misfolded Ig in the cell and how this interaction can be employed to reduce the aggregation that leads to amyloid formation. Aim | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $120,000 | Grant | Trans-NIH Recovery Act Research Support: The VETSA Longitudinal Twin Study of Cognition and Aging is a unique project that provides a comprehensive prospective examination of genetic and environmental influences on cognitive and brain aging with extensive data from neurocognitive, health/medical | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $46,725 | Grant | Trans-NIH Recovery Act Research Support: Alzheimer's disease (AD) is the most common form of neurodegeneration however, adequate therapies do not exist to prevent or treat AD. Since 1999, Abeta immunotherapy has been shown to lower cerebral Abeta levels and improve cognition in AD mouse models. | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| UNIVERSITY OF WASHINGTON | $171,000 | Grant | Trans-NIH Recovery Act Research Support: The parent project aims at deciphering the molecular pathways supporting satellite cell function and at understanding how these are influenced during aging. Age-related skeletal muscle deterioration (sarcopenia) is characterized by a decline in mass, stre | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF PITTSBURGH THE | $93,173 | Grant | Trans-NIH Recovery Act Research Support: This competitive revision application to grant R01AG029546 is submitted in response to NOT-OD-09-058: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications. This revision proposes to add optical brain imaging to our on | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF UTAH, THE | $154,147 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): A recently recognized role of nicotinic acetylcholine receptors (nAChR) is to regulate inflammatory cytokine expression. As we age, changes in nAChR expression are observed and these correlate with dysregulation of inf | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF WASHINGTON | $122,555 | Grant | Trans-NIH Recovery Act Research Support: In the parent grant 1R01AG031136 entitled Identifying and characterizing protein quality control mechanisms in the nucleus we described three aims: (1) determine the regions within San1 responsible for substrate targeting; (2) determine the features of an | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| OKLAHOMA MEDICAL RESEARCH FOUNDATION | $293,400 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this administrative supplement is to accelerate research concerning replenishment of the immune system in adults. Specifically, newly developed reporter mice are being exploited to chart developmental pathways between hematopoietic st | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| THE INSTITUTE FOR CANCER RESEARCH | $10,665 | Grant | Trans-NIH Recovery Act Research Support: Abstract: A major goal of the parent award was to understand the mechanism of replication of hepatitis delta virus (HDV). In most of the ways in which we study the replication of the small circular RNA of HDV, we are actually detecting the accumulation o | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| UNIVERSITY OF MARYLAND | $77,273 | Grant | Trans-NIH Recovery Act Research Support: MCH is a major part of adaptive immune system. Thus, understanding the ancestral synteny of MHC in more details might acquire new insights on the primordial MHC structures and mechanisms vital for a functioning immune system and further reveal new insigh | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $44,748 | Grant | Trans-NIH Recovery Act Research Support: Both naive CD4+ and COB+ T cells are dependent on two types of signaling, from contact with IL-7 and self-MHC/peptide ligands, for their continued survival under normal conditions and to undergo homeostatic proliferation in response to lymphopenia. Naive | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF SOUTH FLORIDA | $68,708 | Grant | Trans-NIH Recovery Act Research Support: Eastern equine encephalomyelitis virus (EEEV) is a serious infection of humans, and is listed as a high- consequence select agent. In studies carried out during the previous funding period, we demonstrated that EEEV ecology in the mid- Southeastern USA di | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $161,161 | Grant | Trans-NIH Recovery Act Research Support: Immune control of HIV-1 is dependent on the migration of HIV-1 specific CTLs towards and colocalization with infected cells. This process is orchestrated by the action of chemokines serving as chemoattractants at sites of infection. We recently demonstrat | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| UNIVERSITY OF KENTUCKY | $32,801 | Grant | Trans-NIH Recovery Act Research Support: Membrane fusion, a process critical for viral entry, is promoted by the paramyxovirus fusion (F) proteins. All F proteins contain a number of common features that play fundamental roles in fusion. However, significant variations exist between F proteins r | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE OF | $16,950 | Grant | Trans-NIH Recovery Act Research Support: Retroviruses have devised a number of strategies to evade cellular mechanisms aimed at preventing retroviral infection. HIV-1 expressesVif, a protein that counteracts the antiviral activity of the cytidine deaminases APOBEC3G and APOBEC3F. The nucleotide | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| NORTH CAROLINA STATE UNIVERSITY | $426,895 | Grant | Trans-NIH Recovery Act Research Support: The long-term aim of this proposal is to develop a technique that will enable highly automated, multi-functional epigenetic profiling of whole chromosomes from single cells. Such a technique will provide a tool for single-molecule studies probing the epig | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $163,349 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Persistence of cancer cells even after surgery and androgen-ablation therapy, their proliferation, androgen- independence and invasion to distant sites is the major cause of deaths in human prostate cancer patients. De | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE | $199,205 | Grant | Trans-NIH Recovery Act Research Support: Esophageal squamous cell carcinoma (ESCC) is one of the most common fatal cancers worldwide, which has a 5-year survival rate of <15%. Significant reduction in the mortality will require successful strategies to diagnose and treat asymptomatic precursor l | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| WAYNE STATE UNIVERSITY (INC) | $367,840 | Grant | Trans-NIH Recovery Act Research Support: The goal of this study is to develop a systems-based intervention to increase the numbers of offers made to patients in order to increase the number of patients enrolling onto trial protocols. We will test the feasibility and efficacy of a two-component | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $385,878 | Grant | Trans-NIH Recovery Act Research Support: Although urokinase (uPA) and its receptor strongly contribute to the dissemination of prostate cancer, the efficacy of existing approaches to disable this system is incomplete, possibly because uPA acts through additional uncharacterized pathways. We rece | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| WAYNE STATE UNIVERSITY (INC) | $323,042 | Grant | Trans-NIH Recovery Act Research Support: The proposed study will test the hypothesis through off-label use of commercially available imaging agents. The rationale for this study is that a successful outcome would lay the foundation for future larger studies of functional ultrasound imaging to a | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $543,645 | Grant | Trans-NIH Recovery Act Research Support: The proposal seeks to develop the first meaningful objective radiographic parameter that correlates with the clinical symptoms of radiation pneumonitis (RP) as an imaging biomarker of RP. RP is the dose limiting toxicity in thoracic radiotherapy for lung | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| UNIVERSITY OF IOWA, THE | $536,296 | Grant | Trans-NIH Recovery Act Research Support: We have just completed a Phase I dose/toxicity trial for children and young adults with recurrent solid tumors using 90Y-DOTA-tyr3-Octreotide (90Y-DOTATOC) to target the somatostatin receptor type 2 (sst2) expressed on tumor cells. Potential subjects were | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $393,250 | Grant | Trans-NIH Recovery Act Research Support: Prostate cancer is the most common cancer and the second leading cause of cancer death affecting men in the United States. Approximately 30% of men with detectable serum prostate-specific antigen (PSA) levels after curative radical prostatectomy have loca | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $412,500 | Grant | Trans-NIH Recovery Act Research Support: Cocaine is a powerful psycho stimulant and one of the most addictive drugs of abuse. Despite decades of efforts, no effective pharmacological treatments have been developed for cocaine addiction or acute cocaine toxicity. There are two main approaches in | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF WASHINGTON | $340,575 | Grant | Trans-NIH Recovery Act Research Support: Marijuana use is among the most frequently used illicit substance among emerging adults (those between the ages of 18 and 25) which places them at high risk for a number of undesirable consequences. Those who report recent frequent use (i.e., 3 times per | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE | $421,530 | Grant | Trans-NIH Recovery Act Research Support: After the Hurricane Katrina disaster in August, 2005 a massive influx of Latinos from Mexico and Central America, mostly undocumented and unaccompanied by their families, came seeking construction work. Post-disaster New Orleans is not only a new receivi | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $291,116 | Grant | Trans-NIH Recovery Act Research Support: Opioid abuse is a common problem in the United States. It is estimated that 2.4 million people in this country use heroin at some time in their lives. Addiction to heroin has several long-term consequences, including molecular changes in the brain, hepati | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| MCLEAN HOSPITAL CORPORATION, THE | $391,415 | Grant | Trans-NIH Recovery Act Research Support: Cue-induced craving is currently not well understood in nicotine dependence, and is a poor predictor of use. However, as with other drugs of abuse, studies suggest that craving measures become more relevant to drug use when the opportunity to use more clo | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| MIND RESEARCH NETWORK, THE | $469,333 | Grant | Trans-NIH Recovery Act Research Support: Real-world experience and clinical research converge in demonstrating that substance-dependent individuals will continue to use drugs despite an often strong desire to cease taking them. This suggests that a cardinal characteristic of dependency may be re | Health and Human Services, Department of / National Institutes of Health | 8/15/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $408,375 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The Sigma-2 receptor is a unique protein found in most mammalian tissues. Sigma-2 receptors play an important role in growth regulation in normal cells and tumor cells of neuronal and non neuronal origin. The Sigma-2 r | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| DUKE UNIVERSITY | $429,000 | Grant | Trans-NIH Recovery Act Research Support: A large body of evidence suggests that ion channels act as force sensors in mechanotransduction systems. In flies, the No mechanoreceptor potential-C (Nomp-C) channel has been suggested to be a force transduction channel in neurons that detect bristle def | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $418,802 | Grant | Trans-NIH Recovery Act Research Support: The long-term goals of the proposed research are to develop tissue-engineering materials (TEM) with enhanced biocompatibility, and flexibility to tailor mechanical properties for a wide range of applications. There are two specific aims for this proposal. | Health and Human Services, Department of / National Institutes of Health | 4/29/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $448,061 | Grant | Trans-NIH Recovery Act Research Support: The aim of this project is to develop a biopsychosocial model that explains how sociodemographic, biosocial, behavioral factors interact with one another to lead to differential oral health in later life. Oral aging indicators examined in this project inc | Health and Human Services, Department of / National Institutes of Health | 9/19/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $325,504 | Grant | Trans-NIH Recovery Act Research Support: The Role of Endogenous Cardiac Glycosides in Outcomes among African Americans with Hypertensive Kidney Disease. Chronic kidney disease (CKD) affects an estimated 19 million adults in the US and is associated with a higher risk of cardiovascular disease (C | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| UNIVERSITY OF PITTSBURGH THE | $416,625 | Grant | Trans-NIH Recovery Act Research Support: Obesity has become the most common nutritional disorder in the developed world and the co-morbidities of obesity contribute significantly to mortality and medical costs throughout the world. Biological or circadian rhythms have profound effects on energy | Health and Human Services, Department of / National Institutes of Health | 6/22/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $410,000 | Grant | Trans-NIH Recovery Act Research Support: Masses of the pituitary gland (sellar masses) are common, representing approximately 15% of all intracranial masses. About half of the sellar masses are caused by a hormone-secreting adenoma and more easily diagnosed because of classical signs and symptom | Health and Human Services, Department of / National Institutes of Health | 5/11/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $415,250 | Grant | Trans-NIH Recovery Act Research Support: Benign prostatic hyperplasia is one of the most common chronic conditions among America men. The traditional, `gold standard', surgical treatment is transuretheral prostatectomy (TURP). However, during the last decade the use of minimally invasive surgica | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| UNIVERSITY OF WASHINGTON | $429,000 | Grant | Trans-NIH Recovery Act Research Support: Although the glomerulus has long since been known to be compromised of four resident cell types, the contributions of the endothelial cell, mesangial cell, and podocyte to glomerular architecture and function have garnered virtually all of the research at | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| UNIVERSITY OF SOUTH FLORIDA | $164,250 | Grant | Trans-NIH Recovery Act Research Support: Increases in childhood obesity are a public health concern worldwide. In the U.S., 17.6 percent of adolescents have high BMIs for their age. Obesity early in life is associated with poorer physical and mental health and social wellbeing, including respira | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $452,400 | Grant | Trans-NIH Recovery Act Research Support: Diabetes causes lower extremity problems in a large number of diabetic patients. Peripheral arterial disease (PAD) can affect up to 29% of all diabetic patients while functional changes in the microcirculation are present in the vast majority of them. The | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| MARQUETTE UNIVERSITY | $393,437 | Grant | Trans-NIH Recovery Act Research Support: Current below the knee (trans-tibial) prostheses utilize elaborate springs and elastomers to store and dissipate energy during ambulation. While these designs are functional, they do not allow for energy input into the system which is necessary for reprod | Health and Human Services, Department of / National Institutes of Health | 7/30/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $422,750 | Grant | Trans-NIH Recovery Act Research Support: This proposal is a substantial revision of application 1 R21 MH079984-01 which was reviewed October 11, 2006 by the Mental Health Services in Non- Specialty Settings review group. Goals, specific aims, and hypotheses have been clarified to be consistent w | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| MOUNTAIN STATES GROUP, INC. | $327,229 | Grant | Trans-NIH Recovery Act Research Support: The Idaho Partnership for Hispanic Mental Health phase one planning project seeks to address the mental health service needs of Mexican immigrants in southwest Idaho through the development of a community-academic partnership. | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $992,987 | Grant | Trans-NIH Recovery Act Research Support: Genotyping the NPF Biobank for Psoriasis Susceptibility Genes This application addresses broad Challenge Area (08) Genomics and Specific Challenge Area: 08-AR-101 Genotyping of Existing Cohorts in Rheumatic, Skin, and Musculoskeletal Diseases. Psoriasis i | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF ROCHESTER | $434,983 | Grant | Trans-NIH Recovery Act Research Support: This current application addresses Regenerative Medicine (11) as the broad challenge area. Specifically, this application seeks further understanding of molecular pathways that control expansion and differentiation of periosteal mesenchymal stem cells (MS | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $997,373 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (03) Biomarker Discovery and Validation and specific Challenge Topic, 03-AR-103: Biomarkers: Bench to Bedside for Autoimmune and Inflammatory Skin and Rheumatic Diseases. Some patients with humoral autoimmun | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $160,650 | Grant | Trans-NIH Recovery Act Research Support: The difference between the number of proteins with known sequence and those with wellstudied function (sequence-function gap) is growing daily. Bioinformatics bridges this gap mostly through homology-based inferences of the type: assume that the function | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| CLEMSON UNIVERSITY | $141,313 | Grant | Trans-NIH Recovery Act Research Support: Human DNA sequence differs among individuals and the most common variations are known as single nucleotide polymorphisms, or SNPs. Studies have shown that non-synonymous coding SNPs (nsSNPs - SNPs occurring in protein coding regions which lead to amino ac | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| CONVERSPEECH LLC | $100,000 | Grant | Trans-NIH Recovery Act Research Support: There has been growing interest in recent years in developing methods that automatically identify Gene Ontology (GO) concepts in the unstructured text of scientific articles. This interest is motivated in part by the need to automate the task of model-org | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| UNIVERSITY OF CHICAGO, THE | $152,930 | Grant | Trans-NIH Recovery Act Research Support: The revised application is in response to PA-06-543, 'Mechanisms, Models, Measurement, & Management in Pain Research (R03).' Consistent with this program announcement, we aim to test hypotheses about the developmental pathways to comorbid pain and depress | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| WINIFRED MASTERSON BURKE MEDICAL RESEARCH INSTITUTE, INC., THE | $467,854 | Grant | Trans-NIH Recovery Act Research Support: The present grant aims to achieve the following outcomes across the two-year funding period: 1. to evaluate whether Transcranial Direct Current Stimulation (tDCS) should be delivered sequentially or in parallel to motor training, to enhance motor pattern | Health and Human Services, Department of / National Institutes of Health | 5/06/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $424,940 | Grant | Trans-NIH Recovery Act Research Support: Myocardial infarction (MI) is a leading cause of mortality in today's society. Injury to myocardium is a manifestation of the intrinsic cellular response to ischemia and of an extrinsic acute inflammation. Recent pre-clinical studies have revealed that pr | Health and Human Services, Department of / National Institutes of Health | 5/18/2009 |
| GEORGIA TECH RESEARCH CORPORATION | $409,082 | Grant | Trans-NIH Recovery Act Research Support: Blood damage caused by flow shear can cause thromboembolic complications that seriously limit the performance of a broad range of cardiovascular hardware including prosthetic valves, bypass pumps, and assist device. An attractive way to mitigate the adver | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $424,832 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Hypertension during pregnancy affects 5-8% of pregnancies in the United States and contributes to serious complications for both the fetus and mother. Hypertension may lead to pre-eclampsia, which can restrict fetal gr | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $423,500 | Grant | Trans-NIH Recovery Act Research Support: Documentation of cardiomyocyte cell cycle activity and myocardial tissue regeneration typically requires extensive histochemical processing and frequently relies on the use of subjective criteria for cell lineage determination. Although reporter transgene | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| UNIVERSITY OF UTAH, THE | $413,875 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The nucleus controls gene expression patterns that characterize the function of individual cells. Responses that occur in the nucleus, such as transcription and splicing of pre-mRNA, are elaborate processes that utiliz | Health and Human Services, Department of / National Institutes of Health | 5/18/2009 |
| SOUTH CAROLINA RESEARCH FOUNDATION | $396,000 | Grant | Trans-NIH Recovery Act Research Support: INTEGRATED RECALL OF DIET AND PHYSICAL ACTIVITY IN CHILDREN Information provided by parents about their children`s dietary intake and/or physical activity (PA) often is inaccurate because children eat meals and are physically active in locations at which | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| FOX CHASE CANCER CENTER | $664,093 | Grant | Trans-NIH Recovery Act Research Support: Abstract Although individuals with ulcerative colitis face an increased risk of developing colorectal cancer, little attention has been given to the establishment of a chemopreventive regimen for this population. The ability of 5-aminosalicyclic acid (5- | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UMDNJ-ROBERT WOOD JOHNSON MEDICAL SCHOOL | $199,282 | Grant | Trans-NIH Recovery Act Research Support: A transgenic murine model of melanoma was developed by the ectopic expression of metabotropic glutamate receptor 1 (murine GRM1 or mGRM1) in melanocytes. We have expanded these original studies and have now shown that over 65% of human melanomas express t | Health and Human Services, Department of / National Institutes of Health | 9/08/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $28,934 | Grant | Trans-NIH Recovery Act Research Support: This project is being supported with funds from the American Recovery and Reinvestment Act, which may involve a reduction in the research aims and scope. If necessary, a revised abstract will be posted soon and this notice removed. DESCRIPTION (provided | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| DUKE UNIVERSITY | $169,650 | Grant | Trans-NIH Recovery Act Research Support: Human cancers are extremely heterogeneous. Integrative cancer systems biology must develop more comprehensive and incisive methods to interrogate various sources of heterogeneity, and to rationally represent their complex interactions in refined predictiv | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $294,930 | Grant | Trans-NIH Recovery Act Research Support: This project is concerned with the development of a new drug development paradigm that focuses on the use of preclinical studies in animals to derive predictive pharmacokinetic [PK] - pharmacodynamic [PD] models that can aid in the rational selection of d | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| WAKE FOREST UNIVERSITY | $267,798 | Grant | Trans-NIH Recovery Act Research Support: Carbon nanotubes are graphene sheets of sp2 bonded atoms rolled seamlessly into a tube of 1.5 - 20 nm in diameter. This material has unique properties, including the ability to generate heat when stimulated with infrared light. We have used the features o | Health and Human Services, Department of / National Institutes of Health | 9/08/2009 |
| UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE | $996,126 | Grant | Trans-NIH Recovery Act Research Support: African-Americans have an approximately 30% to 60% increased incidence of venous thromboembolism (VTE) for unknown reasons.-? The main limitation to studying this disparity is the paucity of African-Americans in most large-scale epidemiological studies.-? | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF CHICAGO, THE | $971,920 | Grant | Trans-NIH Recovery Act Research Support: P311 is an 8 kDa intracellular protein highly conserved across species. P311 does not belong to any established protein family; neither has signature motifs that could suggest function. In mouse and human P311 is produced in the brain, in vascular smooth | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $992,690 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (04) Clinical Research and specific Challenge Topic, 04-HL- 113: Cost-Effective Trials of CVD Prevention in Persons with Low Short-Term Risk. Lipid-lowering therapy with HMG-CoA reductase inhibitors (statins | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| BOSTON MEDICAL CENTER CORPORATION | $999,390 | Grant | Trans-NIH Recovery Act Research Support: We plan to conduct a series of 3 studies in which the results of the first 2 will inform the design of the third. In study 1, we will evaluate alternative methods and protocols for measureing medication adherence and using the results to improve adherenc | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $997,753 | Grant | Trans-NIH Recovery Act Research Support: This grant addresses Challenge Area (03) Biomarker Discovery and Validation and specific Challenge Topic, 03-HL-101 and is entitled, ?Biomarkers of Sudden Death and Progressive Heart Failure?. More than 5 million people in the United States alone have adv | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| ALBANY MEDICAL COLLEGE | $406,556 | Grant | Trans-NIH Recovery Act Research Support: Cardiovascular disease is the major cause of death in the United States with much of the morbidity and mortality resulting from plaque rupture. Strokes account for approximately 157,000 of those deaths each year. As the majority of strokes result from pla | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| DUKE UNIVERSITY | $429,000 | Grant | Trans-NIH Recovery Act Research Support: Ischemic stroke is caused by cerebral blood flow (CBF) inadequate to allow brain tissue survival. It is known from humans treated with tissue plasminogen activator that ischemic tissue can be salvaged from infarction by thrombolytic CBF restoration. This | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $419,265 | Grant | Trans-NIH Recovery Act Research Support: Tau is a natively unfolded protein that has been implicated in the pathogenesis of several neurodegenerative disorders such as Alzheimer's disease (AD). A number of studies suggest that aggregates of tau contribute to neuronal death and dysfunction in AD | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| UNIVERSITY OF FLORIDA | $402,875 | Grant | Trans-NIH Recovery Act Research Support: Traumatic brain injury and stroke each affect millions of people yearly; aneurysmal subarachnoid hemorrhage patients suffer from both. Utilizing aneurysmal subarachnoid hemorrhage patients as model for these types of brain injury, it may be possible to id | Health and Human Services, Department of / National Institutes of Health | 5/25/2009 |
| ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE | $327,900 | Grant | Trans-NIH Recovery Act Research Support: Disorders of the central nervous system are often associated with little or no recovery due to in part to poor neural regenerative capacity, damaging mechanisms that persist after initial neuronal injury, and inhibitory properties intrinsic to myelin. Reg | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF CHICAGO, THE | $441,701 | Grant | Trans-NIH Recovery Act Research Support: The focus of this application is on abnormalities of TDP-43, a protein that underlies a number of neurodegenerative diseases (frontotemporal lobar dementia [FTLD], Parkinson's disease [PD], and amyotrophic lateral sclerosis [ALS]). In 2006, ubiquinated cy | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $435,959 | Grant | Trans-NIH Recovery Act Research Support: Several devastating diseases that are caused by nerve degeneration, including amyotrophic lateral sclerosis (ALS), have been unified by a common underlying theme: the clumping of a protein, TDP 43, in nerve cells. Our proposed studies aim to provide new m | Health and Human Services, Department of / National Institutes of Health | 9/20/2009 |
| UNIVERSITY OF FLORIDA | $535,483 | Grant | Trans-NIH Recovery Act Research Support: Proteomics is one of emerging tools for drug discovery and medical diagnostics. Two-dimensional gel electrophoresis is one of the most potent methods in proteomics studies. The goal of this project is to develop a lab-on-a-chip device that will improve | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |