Listing all stimulus spending by amount, in descending order. Return to National Institutes of Health page
Amount refers to both the amount of stimulus funding going toward the project and the face value of the loan.
| Recipient | Amount | Type | Description | Federal Dept./Agency | Date |
|---|---|---|---|---|---|
| TRUSTEES OF INDIANA UNIVERSITY | $380,988 | Grant | Trans-NIH Recovery Act Research Support: Current 2D and 3D deconvolution and analysis techniques are not well suited for deep tissue microscopy. Most assume the point spread functions (PSFs) to be symmetric or spatially invariant, which is not the case for thick samples. In addition, many utiliz | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF WASHINGTON | $616,284 | Grant | Trans-NIH Recovery Act Research Support: Over the last decade, ubiquitin has emerged to rival phosphorylation as one of the cell's most broadly utilized protein modifications, and it has become widely appreciated that ubiquitination serves critical regulatory roles in virtually every aspect of c | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| HOFSTRA UNIVERSITY | $283,512 | Grant | Trans-NIH Recovery Act Research Support: A Home based intervention for young children with intellectual disabilities in Vietnam. | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| UNIVERSITY OF PUERTO RICO-MEDICAL SCIENCES CAMPUS | $1,046,897 | Grant | Trans-NIH Recovery Act Research Support: Diversity-promoting Institutions Drug Abuse Research Program (DIDARP) at the Graduate School of Public Health , aims to increase the instituion's drug abuse research capacity through mentored research experiences for faculty at different levels of researc | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $1,087,998 | Grant | Trans-NIH Recovery Act Research Support: This early childhood obesity prevention study focuses on low-income and often minority families in a small city who have disproportionately high obesity rates. The interdisciplinary research team with expertise in childhood obesity, family development, he | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| WAKE FOREST UNIVERSITY | $407,000 | Grant | Trans-NIH Recovery Act Research Support: IL-4- and IL-13- producing type 2 T cells, are critical for the development of atopy and contribute to asthma pathogenesis by a variety of mechanisms. PGD2, a prostaglandin produced predominantly by mast cells, is involved in chemoattraction of eosinophil | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| AUBURN UNIVERSITY | $401,500 | Grant | Trans-NIH Recovery Act Research Support: The overall purpose is to determine the potential roles of the up-regulated genes in insecticide resistance in mosquitoes. We expect that comparison of 1) levels of resistance and the levels of gene expression and 2) the levels of silenced gene expression | Health and Human Services, Department of / National Institutes of Health | 5/06/2009 |
| TEXAS A&M UNIVERSITY SYSTEM,THE | $421,918 | Grant | Trans-NIH Recovery Act Research Support: The goal of this proposal is to delineate the viral genes that lead to severe acute respiratory syndrome (SARS) utilizing a novel rodent model of SARS. SARS infected over 8,000 persons globally with over 700 deaths. We propose to use a MHV-1 infected mous | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| THE GEORGE WASHINGTON UNIVERSITY | $435,422 | Grant | Trans-NIH Recovery Act Research Support: The objective of this application is to investigate the molecular mechanisms of anti-HIV activity of the LXR agonist TO-901317, a compound stimulating reverse cholesterol transport, and to test this compound in an in vivo model of HIV-1 infection, humaniz | Health and Human Services, Department of / National Institutes of Health | 5/06/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $144,226 | Grant | Trans-NIH Recovery Act Research Support: This is a administrative supplement application for my R01ES009111 grant. It proposes to further develop methods for SNP SNP interactions and pathways based analysis of SNP data. It will support one postdoc for one year and a PhD student at partial suppor | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $393,441 | Grant | Trans-NIH Recovery Act Research Support: This one year supplement grant application is proposed to expand the scope of the original aims of a currently funded R01 to assess the genotoxic mechanism of targeted cytoplasmic irradiation. The overall goal of this application is to elucidate the con | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF WASHINGTON | $66,581 | Grant | Trans-NIH Recovery Act Research Support: We propose to elucidate molecular mechanisms underlying paraquat-induced dopamine neuron death in vitro and in vivo. We also propose to identify neuroprotective growth factors and elucidate downstream protective mechanisms against paraquat neurotoxicity. | Health and Human Services, Department of / National Institutes of Health | 7/11/2009 |
| UNIVERSITY OF FLORIDA | $378,067 | Grant | Trans-NIH Recovery Act Research Support: Dichloroacetate (DCA) is an environmentally important xenobiotics, widely distributed in our biosphere. It is also employed as an investigational drug for treatment of congenital forms of lactic acidosis (CLA). The cardinal manifestations of chronic DCA e | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $313,600 | Grant | Trans-NIH Recovery Act Research Support: The goal of this proposal is to elucidate the eukaryotic DNA damage response through an integrated experimental/computational approach leading to in-silico models of signaling and regulatory networks. Comparative modeling of the networks induced by differ | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| THOMAS JEFFERSON UNIVERSITY | $867,620 | Grant | Trans-NIH Recovery Act Research Support: Since recent studies suggest that environmental toxicants can affect the integrity of the genome through effects on epigenetic mechanisms, the extent to which this occurs with different levels and types of Pb exposure need to be studied. Thus, the researc | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $370,440 | Grant | Trans-NIH Recovery Act Research Support: This ARRA supplement will help us capitalize on our recent molecular insights gained in the parent grant by developing a high-throughput assay to screen for molecules that specifically inhibit Rev1/Rev3/Rev7-dependent translesion synthesis (TLS), which is | Health and Human Services, Department of / National Institutes of Health | 8/15/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $98,028 | Grant | Trans-NIH Recovery Act Research Support: The proposed research activities are within the scope and research protocol of an active NIEHS-supported research project R01 ES015988, entitled ?Glutamate Receptors, Oligodendrocytes, and Lead Neurotoxicity?. There are no major changes to the project in | Health and Human Services, Department of / National Institutes of Health | 6/17/2009 |
| UNIVERSITY OF PITTSBURGH THE | $32,573 | Grant | Trans-NIH Recovery Act Research Support: Silicosis develops many years after initial exposure to silica particles and is characterized by chronic inflammation, lung fibrosis and ultimately respiratory impairment. There is no effective treatment for silicosis. The biochemical mechanisms behind si | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| DREXEL UNIVERSITY | $1,111,301 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this supplement is to accelerate enrollment of the EARLI cohort as well as expand enrollment diversity and enhance retention. Each of the four study sites will hire one additional dedicated outreach/recruitment specialist to help increase | Health and Human Services, Department of / National Institutes of Health | 9/20/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $167,958 | Grant | Trans-NIH Recovery Act Research Support: The inability to communicate underlies one of the most disabling aspects of injury to the central nervous system, and includes the inability to perform rudimentary tasks such as flexing and extending ones' limb or moving a simple cursor on a screen. While | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| BOSTON COLLEGE, TRUSTEES OF | $378,000 | Grant | Trans-NIH Recovery Act Research Support: A General Bayesian Polymorphism Discovery Tool: This project is aimed at the creation of a computer software package that can be used for the discovery of single-nuclotide polymorphisms (SNPs) and short insertion / deletion type genetic variations (short | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF ARIZONA | $377,500 | Grant | Trans-NIH Recovery Act Research Support: Project Narrative CD46 is a protein that regulates many immune functions in man. CD46 comes in two main forms, and there is reason to believe that the result of CD46 stimulation depends on the relative levels of the two activated forms. CD46 is also the t | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| HEALTH RESEARCH, INC. | $256,057 | Grant | Trans-NIH Recovery Act Research Support: A critical component of the acute inflammatory response is the rapid mobilization of blood-borne lymphocytes into secondary lymphoid organs. These organs are the staging ground for lymphocyte encounters with antigens and foreign pathogens during the initi | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $123,319 | Grant | Trans-NIH Recovery Act Research Support: Our current understanding of cutaneous innate immunity states that the skin initially protects against infection by establishing physical and chemical barriers to microbes. These include the stratum corneum, antimicrobial peptides, reactive oxygen species | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF CHICAGO, THE | $195,000 | Grant | Trans-NIH Recovery Act Research Support: This revised proposal (DK081513) focuses on the investigation of serine/threonine phosphorylation of IRS-2 by ERK, mTOR and p70S6K in mediating initial hepatic insulin resistance, Insulin action in the liver plays an important role in maintaining glucose | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| CHILDRENS HOSPITAL OF PHILADELPHIA | $567,970 | Grant | Trans-NIH Recovery Act Research Support: This is a translational research study of the role of glucagon-like peptide-1 (GLP-1) in congenital hyperinsulinism (CHI), the most frequent cause of persistent hypoglycemia in children. CHI is a genetic disorder of pancreatic ?-?-cell function characteri | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| UNIVERSITY OF MIAMI | $191,250 | Grant | Trans-NIH Recovery Act Research Support: The role of innervation for hormone secretion in human islets. Understanding the biology of the endocrine pancreas, the islets of Langerhans, is crucial for any type of therapy for diabetes mellitus, a devastating disease affecting millions worldwide. | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| SCIENTIFIC ANALYSIS CORPORATION | $974,701 | Grant | Trans-NIH Recovery Act Research Support: Meta-Analysis Systematic and Design Errors: Alcohol Use and Disease Outcomes The meta-analysis of relevant epidemiological studies evaluating alcohol consumption and multiple disease outcomes should inform clinicians and public health policy by more care | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $158,227 | Grant | Trans-NIH Recovery Act Research Support: This work is directed towards obtaining a better understanding of how the antigen receptor on B lymphocytes contributes to the development of different peripheral B cell populations and to the function of B lymphocytes in humoral immunity. Molecules that | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| THE VANDERBILT UNIVERSITY | $40,646 | Grant | Trans-NIH Recovery Act Research Support: The parent grant focus is on investigating the role of mycobacterial antigens in sarcoidosis pathogenesis. Recent studies from independent laboratories have noted an association with mycobacteria and sarcoidosis pathogenesis. We found a statistically sig | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $25,214 | Grant | Trans-NIH Recovery Act Research Support: All bacteria possess a single methionine aminopeptidase (MetAP) that is absolutely essential for cell survival. In contrast, eukaryotic cells express two MetAP enzymes and can survive if one of them is eliminated by genetics or inhibition. This enzyme is | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $997,006 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (06) Enabling Technologies and specific Challenge Topic 06-HG-103: Methods to sequence highly variable, repeat-rich regions of complex genomes. A remarkable 45% of our genome consists of repetitive elements | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| CHILDRENS HOSPITAL OF PHILADELPHIA | $996,977 | Grant | Trans-NIH Recovery Act Research Support: This application is intended for the (06) 'Enabling Technologies' challenge area & (06- HG-102*) 'Technologies for obtaining genomic, proteomic, & metabolomic data from individual viable cells in complex tissue' challenge topic. The specialized microenvir | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $899,991 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (02) Bioethics and specific Challenge Topic, 02-HG-101: Informed consent and data access policies. The ethical, legal, and social issues (ELSI) underlying the development and implementation of state-sponsore | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $997,444 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (14) Stem Cells and specific Challenge Topic, 15-HL-102: Develop new therapeutic strategies for heart, lung, and blood diseases based on microRNA technology. Congenital heart malformations are the most commo | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $829,915 | Grant | Trans-NIH Recovery Act Research Support: Develop technologies for assessment of aortic aneurysms prone to rupture or dissection. Thoracic and abdominal aortic aneurysms (TAA and AAA) are life threatening conditions that comprise the thirteenth leading cause of death in the United States. For bot | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| EMORY UNIVERSITY | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: Hybrid Revascularization vs Percutaneous Coronary Intervention: A Planning Grant This application addresses broad Challenge Area (04) Clinical Research and specific Challenge Topic, 04-HL-115: Treatment of stenosed coronary arteries with hybrid coronary | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $974,586 | Grant | Trans-NIH Recovery Act Research Support: Current FDA post-marketing drug safety monitoring relies principally on passive surveillance via MedWatch reports to the Adverse Event Report System. By contrast, active surveillance using population-based healthcare utilization databases could improve th | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| CHILDRENS HOSPITAL OF PHILADELPHIA | $988,260 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (10) Information Technology for Processing Healthcare Data, 10-LM-102: Advanced decision support for complex clinical decisions. The lack of prescribing information & meaningful dosing guidance places an inc | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| MAYO CLINIC | $497,477 | Grant | Trans-NIH Recovery Act Research Support: Our proposal addresses the following challenge area: 06-LM-101* Intelligent Search Tool for Answering Clinical Questions. Develop new computational approaches to information retrieval that would allow a clinician or clinical researcher to pose a single qu | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| THE CHILDRENS HOSPITAL LOS ANGELES | $989,855 | Grant | Trans-NIH Recovery Act Research Support: Artificial Intelligence (AI) and advanced computational techniques, applied to complex, multidimensional, streaming, clinical data (historic, physiologic, laboratory, imaging, etc) from disparate health care digital data sources, can be used to produce in | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $1,554,575 | Grant | Trans-NIH Recovery Act Research Support: The objective of this proposal is to develop a Core Center within the Center for Excellence in Pulmonary Biology to conduct multidisciplinary, biomedical research to elucidate the molecular mechanisms that direct alveolar development. This Core Center wil | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $1,302,250 | Grant | Trans-NIH Recovery Act Research Support: Over the past two decades the importance of glial cells in normal brain development has become increasingly appreciated. In addition to their well recognized role in normal brain function, dysfunction of glial cells are now recognized to be of critical im | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $783,474 | Grant | Trans-NIH Recovery Act Research Support: We appreciate the opportunity to refocus this application to achieve a single important aim related to our understanding of young adults' use of male liquor (ML), other alcoholic beverages, and marijuana (MJ), all of which confer high risks for experienci | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| UNIVERSITY OF WASHINGTON | $1,182,898 | Grant | Trans-NIH Recovery Act Research Support: Project NarrativeThe proposed research in this first time RO1 has important implications for improving the health of functionally impaired older Americans and their informal caregivers in ethnically diverse and vulnerable communities. By identifying the r | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| RFCUNY - HUNTER COLLEGE | $781,505 | Grant | Trans-NIH Recovery Act Research Support: ARRA - TRANS-NIH RECOVERY ACT RESEARCH SUPPORT -Chronic inflammation is a critical factor in the pathogenesis of ParkinsonG??s disease (PD). Neuronal and glial prostaglandins mediate proinflammatory responses, but there is a profound gap in our understand | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF WASHINGTON | $592,410 | Grant | Trans-NIH Recovery Act Research Support: Patients with Werner syndrome exhibit many of the features of premature aging including atherosclerosis and an increase in specific cancers. The gene mutated in Werner syndome, WRN, is a member of the RecQ family of DNA helicases and encodes both 3'?5' DN | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| NEW YORK UNIVERSITY (INC) | $828,668 | Grant | Trans-NIH Recovery Act Research Support: Two billion people - one third of the world's population - live at risk for malaria and some 1 billion people carry the parasite. Clinical malaria hits 300 million to 500 million people each year, killing 2 million to 3 million - most of them children. An | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF MIAMI | $252,450 | Grant | Trans-NIH Recovery Act Research Support: Recently a novel intracellular virus recognition pathway was described that appears to be crticial for host innate immune responses to a viral infection. We aim to further dissect this pathway and explore its ramifications. Given the critical nature of | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $743,208 | Grant | Trans-NIH Recovery Act Research Support: The worldwide AIDS epidemic is most devastating in developing countries where more than 40 million people are infected. In addition, to the risk of HIV-1, the majority of inhabitants in developing countries are also infected with immune suppressive helmi | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| UNIVERSITY OF CHICAGO, THE | $998,787 | Grant | Trans-NIH Recovery Act Research Support: Genome-wide Determinants of Prognosis for Early-Onset Breast Cancer This application addresses broad Challenge Area (08) Genomics and specific Challenge Topic, 08-CA-101: Augmenting Genome-Wide Association Studies Prognosis for breast cancer is disproport | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| ST. JUDE CHILDREN'S RESEARCH HOSPITAL | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: Acute lymphoblastic leukemia (ALL) is one of the leading causes of cancer related death in the adolescent and young adult (AYA) population. Relative to younger children with ALL, the overall outcomes in AYA ALL are significantly poorer. Whether these outc | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF WASHINGTON | $857,440 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (04) Clinical Research and Specific Challenge Topic, 04-DA-102: A New Look at Longitudinal Data. Despite decades of research on the etiology, prevention and treatment of substance use disorders, scientific i | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF MASSACHUSETTS | $995,654 | Grant | Trans-NIH Recovery Act Research Support: The ultimate goal of this research is to fundamentally change the ways in which behavioral interventions are delivered. We propose an innovative mobile Enabling Technology-iHeal-that recognizes stressors that threaten a patients recovery and then delivers | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK INC | $999,015 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (03) Biomarker Discovery and Validation, and Specific Challenge topic 03-DA-101, Biomarkers for Pain. The challenge Pain is a central health problem that affects quality of life and productivity for a large | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: The increasing recognition of the importance of epigenetic regulation of gene expression for numerous areas of biology and medicine has led to a growing interest in this field. Despite many advances, our understanding of the molecular aspects involved in | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $772,919 | Grant | Trans-NIH Recovery Act Research Support: It is projected that by 2030 there will be over 40 million adults and over 2 million children with hearing loss in the United States. The average reduction in earning potential for individuals with hearing aids is estimated to be $11,500 per year and $23 | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF ARIZONA | $897,566 | Grant | Trans-NIH Recovery Act Research Support: Proper salivary gland function is critical for oral health. Radiation therapy for head and neck cancer often causes significant secondary side effects that impact normal salivary gland function, most commonly xerostomia. The ensuing salivary gland hypofun | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $996,284 | Grant | Trans-NIH Recovery Act Research Support: Smoking Interventions for Hospital Patients: A Comparative Effectiveness Trial Project Summary/Abstract The Challenge: This application addresses broad Challenge Area (04), Clinical Research, and specific Challenge Topic, 04-HL-116: Cost-effective strateg | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: Sleep loss is a major American health problem. The proposed studies will determine a biomarker for sleep loss. We hypothesize there are molecular signatures that reflect the state of sleepiness. | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $810,608 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (05) Comparative Effectiveness Research and specific Challenge Topic (05-HL-102) Treatment of Obstructive Sleep Apnea. About 15-30% of obstructive sleep apnea (OSA) patients have a poor tolerance for nasally | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $972,665 | Grant | Trans-NIH Recovery Act Research Support: A new generation of highly selective, protease-specific anticoagulant drugs is entering clinical applications, but we have an incomplete understanding of how these drugs attenuate inflammatory processes in cardiovascular diseases, obesity, autoimmune diso | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| MAHARISHI UNIVERSITY OF MANAGEMENT RESEARCH INSTITUTE | $498,981 | Grant | Trans-NIH Recovery Act Research Support: The broad Challenge Area is: 09 Health Disparities. The specific Challenge Topic is: Develop tools to detect early indicators of health disparities, and to test collaborative interventions to reduce differential health care or outcomes for heart, lung, an | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $970,456 | Grant | Trans-NIH Recovery Act Research Support: This application is in response to Challenge Area 04-HL-104, 'Perform secondary analyses of existing data to answer important clinical and preventive medicine research questions.' The specific topic is #8, 'Analysis of genetic markers related to risk fact | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $730,749 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (06) Enabling Technologies and specific Challenge Topic, 06-HL-105: Develop transgenic animal models that are informative for understanding chronic inflammation in humans. Chronic noncommunicable diseases (C | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $996,025 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (15) Translational Science, and specific Challenge Topic 15-OD(ORDR)-101* 'Pilot projects for prevention, early detection and treatment of rare diseases.' Lymphangioleiomyomatosis (LAM) is an often-fatal rar | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| NEW YORK UNIVERSITY (INC) | $948,608 | Grant | Trans-NIH Recovery Act Research Support: Neural cell adhesion molecule (NCAM) is key in leucocyte adhesion to endothelial cells. Upon signaling by chemokines such as MCP1 leukocytes fall into the area of endothelial cells. Tethering of the endothelial cells to leukocyte cadherins is followed b | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF WASHINGTON | $953,162 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (04) Clinical Research and specific Challenge Topic, 04-OD-101: Develop and Validate Behavioral Metrics to Measure the Impact of Chronic Pain. Acute pain is a normal sensation triggered in the nervous system | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $223,791 | Grant | Trans-NIH Recovery Act Research Support: Effect of Adenosine A2 receptor activation on the mitochondrial death pathway (A The main purpose of the supplement is to characterize the exact role of zinc released during reperfusion in the cardioprotective effect of A2 receptor activation in rat and m | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF IOWA, THE | $232,992 | Grant | Trans-NIH Recovery Act Research Support: Intracranial aneurysms are abnormal dilations of brain arteries that may rupture in some patients causing stroke and possibly death. Some treatment modalities are available, but they carry risks to patient health and hence best performed only on aneurysms | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $19,256 | Grant | Trans-NIH Recovery Act Research Support: Pending | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| BRIGHAM YOUNG UNIVERSITY | $76,409 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this study is to elucidate the biochemical and molecular mechanisms by which the interaction of selenium (Se) and phytoestrogens reduces the risk for prostate cancer. The objective is highly significant; if successful, the study could provi | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| INDIANA STATE UNIVERSITY | $123,073 | Grant | Trans-NIH Recovery Act Research Support: Angiogenesis is required for the growth and metastasis of cancers. One of the critical events that occurs during tumor formation, is the remodeling of the angiostatic vascular microenvironment to a pro-angiogenic microenvironment. This remodeling provid | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| MISSOURI STATE UNIVERSITY | $29,887 | Grant | Trans-NIH Recovery Act Research Support: Focus on manufacturing RNA-bound nanoparticles (RNPs). For this purpose gold, manganese or zinc-based core nanoparticles (NPs) will be prepared and RNA attached via delivery-enhancing materials (protamine or PAMAM dendrimer). Ultimately, as proof-of-princ | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| RFCUNY - BROOKLYN COLLEGE | $39,580 | Grant | Trans-NIH Recovery Act Research Support: To support small scale research projects conducted by faculty in primarily baccalaureate degree-granting domestic institutions. Awards are for up to $75,000 for direct costs (plus applicable indirect costs) for periods not to exceed 36 months. | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| MISSISSIPPI STATE UNIVERSITY | $115,129 | Grant | Trans-NIH Recovery Act Research Support: Research will be conducted to improve the performance and capability to resolve the widest possible variety of racemates of solid phase supported oligoproline chromatography columns. One goal is to equal or surpass the capabilities of the best known comm | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| CREIGHTON UNIVERSITY | $129,949 | Grant | Trans-NIH Recovery Act Research Support: Development of Artificial Agonists for a Bacterial Riboswitch The threat of bacterial infections due to lack of effective antibiotics has come to the forefront as these pathogens become resistant to almost every antibiotic available to the public. The ne | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| EMORY UNIVERSITY | $982,444 | Grant | Trans-NIH Recovery Act Research Support: Epigenetic Biomarkers of Early Psychotropic Medication Exposure The use of antipsychotics, antidepressants, and anti-epileptics in both pre-pubertal and post-pubertal windows of brain development raise concerns about the functional effects of psychotrop | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE | $926,632 | Grant | Trans-NIH Recovery Act Research Support: This application addresses Broad Challenge Area '(04): Clinical Research' and Specific Challenge Topic '04-MH-103: Interventions That Target Symptom Dimensions of Childhood-Onset Mental Disorders.' The family of cognitive-behavioral therapies (CBT) is a r | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $828,258 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad challenge area (15) Translational Science and specific challenge topic 15-MH-101, Effects of Psychotropic Medications on Neurodevelopment and Behavior in Animal Models'. Antidepressants and anxiolytics are increasingly pre | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $985,802 | Grant | Trans-NIH Recovery Act Research Support: This proposal is called: A Vision of Hope: Integration of Palliative Care in Chronic Pediatric Disease. The project is directly responsive to the specific challenge topic, Methods to Enhance Palliative Care and End-of-Life Research. It is designed to impr | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF IOWA, THE | $933,051 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (15): 15-NS-102: Translation of Gene Silencing Therapeutics. The proposed challenge set forth in the RFA is to extend the current understanding of the feasibility and safety of RNA interference (RNAi) therap | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| SUTTER WEST BAY HOSPITALS | $176,799 | Grant | Trans-NIH Recovery Act Research Support: This one-year grant will support planning and protocol development for a 12-month, multi-center randomized trial in which older adults (ages 65 and older) with insomnia will be randomized to one of three treatment arms: 1) Zolpidem (Ambien); 2) Cognitive | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $947,869 | Grant | Trans-NIH Recovery Act Research Support: In adult mammals, muscle stem cells (MuSCs) proliferate less, there is less new muscle produced, and there is more fibrosis, than in young mammals. These effects are at least partly due to soluble molecules that regulate MuSCs and their progeny. The conce | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| THE VANDERBILT UNIVERSITY | $998,778 | Grant | Trans-NIH Recovery Act Research Support: A full 1 in 5 children in the US has a developmental disability, and the prevalence rate for autism spectrum disorders (ASD) is especially high (1 in 150 children). As many as 20% of US families are raising children with developmental disabilities, and th | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $999,869 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad challenge area 'Stem cells' and specific area: 'Understanding the Heterogeneity of Cancer and its Environment' (14-CA-102). Tumor stroma interactions are widely recognized to be crucial modifiers of the biology of cancer, | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $965,803 | Grant | Trans-NIH Recovery Act Research Support: This project, 'Engineered in vivo nuclear fusion: application to regenerative medicine,' focuses on the development of a new cell-based strategy for regenerative medicine and gene therapy which depends upon the ability to genetically engineer hematopoieti | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $984,658 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (03) Biomarker Discovery and Validation and specific Challenge Topic 03-DK-101: 'Discovery of biomarkers for disease risk, progression or response to therapy in diseases of interest to NINDK'. Loss of insuli | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| CLARK ATLANTA UNIVERSITY, INC. | $568,052 | Grant | Trans-NIH Recovery Act Research Support: The transformation of the prostate epithelium, and progression to invasive carcinoma, involves de-regulation of the differentiation process, increased proliferation and decrease in apoptosis. A family of transcriptional regulators, known to regulate all t | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| TRUSTEES OF CLARK UNIVERSITY | $600,259 | Grant | Trans-NIH Recovery Act Research Support: Depression is one of the most prevalent and disabling psychiatric disorders, and evidence suggests that low-income Latinos may be at particularly high risk for experiencing the disorder. However, utilization of formal mental health services is very low in | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $63,602 | Grant | Trans-NIH Recovery Act Research Support: Scholars have speculated about the role of historical and social factors in the changing profile of health disparities by gender and race; but have provided little empirical evidence with which to evaluate those speculations. I propose the first systemati | Health and Human Services, Department of / National Institutes of Health | 9/19/2009 |
| SIALIX, INC. | $152,526 | Grant | Trans-NIH Recovery Act Research Support: Possible development of diagnostic products for Rheumatoid Arthritis. Specifically, these diagnostics will identify patients who have disease exacerbations due to Neu5Gc accumulation in joints from dietary sources combined with certain anitNeu5Gc antibodi | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| SONETICS ULTRASOUND, INC | $144,873 | Grant | Trans-NIH Recovery Act Research Support: The goal of the proposed program is to address several technical feasibility questions (in Phase I), and then demonstrate (in a subsequent Phase II) incorporation of Sonetics' groundbreaking CMUT-in-CMOS ultrasound transducer technology into a novel, high | Health and Human Services, Department of / National Institutes of Health | 8/07/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $383,958 | Grant | Trans-NIH Recovery Act Research Support: Natural Killer T (iNKT) cells represent a lymphocyte population that has evolved to recognize glycolipid antigens presented by CD1d. Upon recognition of glycolipids, iNKT cells respond within hours, reminiscent of innate rather than adaptive functions. Th | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $402,357 | Grant | Trans-NIH Recovery Act Research Support: Modern electron cryo-microscopy and computer-based, 3D image reconstruction techniques are revolutionizing the way structures of large and complex biomacromolecular machines are studied. These methods provide keys to understanding at the molecular level h | Health and Human Services, Department of / National Institutes of Health | 5/12/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $441,875 | Grant | Trans-NIH Recovery Act Research Support: This proposal addresses the great need for definitive evidence to test the prevalent dogma that Foxp3+fTregulatory cells are essential for the acceptance of physiologically relevant MHC incompatible organ grafts. MHC-mismatched mouse renal allografts are | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON | $99,985 | Grant | Trans-NIH Recovery Act Research Support: The long term goal of this research project is to understand the role of ehrlichial glycoproteins in protective immunity to Ehrlichia chaffeensis. The proposal aims to further the limited understanding of ehrlichial glycoproteins and their role in immunit | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| NEW YORK MEDICAL COLLEGE | $73,537 | Grant | Trans-NIH Recovery Act Research Support: T. gondii is an obligate intracellular category B priority pathogen that causes the disease toxoplasmosis and is a model system for other priority B protozoa including Cryptosporidium parvum and Cyclospora caytanensis. Our long-term objective of this gran | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | $53,766 | Grant | Trans-NIH Recovery Act Research Support: Ribosome inactivating proteins (RIPs) have been used as instruments of biological warfare and terrorism. Ricin is a heterodimeric plant toxin that consists of A and B-chains and the prototype of type II RIPs. Its B- chain is a lectin that enables cell bin | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| THE VANDERBILT UNIVERSITY | $159,336 | Grant | Trans-NIH Recovery Act Research Support: The need for a rapid response to new bioterror threats and emerging infectious diseases is frustrated by the slow pace of drug discovery. We hypothesized in Specific Aims 2 and 3 (see below) that the protein synthetic machinery can be engineered for the r | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $200,000 | Grant | Trans-NIH Recovery Act Research Support: The goals of this administrative supplement that will be accomplished within two years are to obtain a complete in vivo temporal gene expression map during Vibrio cholerae infection of an animal model. The proposed experiments are a direct outgrowth of ex | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $191,682 | Grant | Trans-NIH Recovery Act Research Support: Innate immune responses of sinonasal epithelial cells to influenza infection in chronic rhinosinusitis with polyps: The purpose of the parent grant is to study innate immune mechanisms that underlie chronic rhinosinusitis with polyps (CRSwNP), which is a | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF CHICAGO, THE | $251,132 | Grant | Trans-NIH Recovery Act Research Support: Transplanted organs such as the skin, lung and small bowel are more immunogenic and more resistant to tolerance induction than the heart and kidney. We reasoned that transplantation of the former organs would more likely result in the concurrent exposure | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| MISSOURI SYSTEM, UNIVERSITY OF | $72,900 | Grant | Trans-NIH Recovery Act Research Support: We request an administrative supplement to purchase a new piece of equipment that would accelerate the pace of our NIH-funded project to study HIV-1 assembly. The long-term goal of the parent project is to understand how assembling HIV-1 particles are a | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| MISSOURI SYSTEM, UNIVERSITY OF | $60,777 | Grant | Trans-NIH Recovery Act Research Support: We request an administrative supplement to purchase a fluorescence microscope which we will use to monitor HIV-1 replication, intracellular aptamer distribution and propagation of infectious HIV-1. A fluorescence microscope is absolutely essential to mod | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF UTAH, THE | $83,904 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): We propose to develop novel inhibitors of HIV entry that target the highly conserved N-trimer pocket region of HIV gp41. Inhibition of this essential component of HIV's fusion machinery prevents viral entry and the est | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| DUKE UNIVERSITY | $74,071 | Grant | Trans-NIH Recovery Act Research Support: Progress in biomedical research and its translation into clinical practice require the integration of data across multiple scales (molecules, cells, organisms), organism types, and fields of research. The need for data integration is especially acute in i | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $108,950 | Grant | Trans-NIH Recovery Act Research Support: Our investigations of POH, a hereditary form of heterotopic (extra skeletal) ossification, are an opportunity to understand key factors regulating stem cell fate decisions, specifically those in the musculoskeletal system. Increased understanding of heter | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF WASHINGTON | $428,966 | Grant | Trans-NIH Recovery Act Research Support: AbstractThis is a competitive revision application for R01 AR048328 in response to NIH Notice NOT-OD-09-058: 'NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications'. Osteogenesis Imperfecta (OI) is a genetic disease ca | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF NOTRE DAME DU LAC | $7,260 | Grant | Trans-NIH Recovery Act Research Support: Osteoporosis is a major health concern among Americans. Osteoporosis is normally characterized by a loss of bone density leading to increased fracture risk. Due to lack of specificity and sensitivity of bone density as a diagnostic measure, focus has shif | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| MISSOURI SYSTEM, UNIVERSITY OF | $13,088 | Grant | Trans-NIH Recovery Act Research Support: Normal functioning of the adult skeleton requires mechanical loading to maintain bone mass. However the precise mechanism by which bone perceives load, transduces that stimulus into a biochemical response, and ultimately forms new bone is poorly understo | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| NATIONAL UNIVERSITY OF HEALTH SCIENCES | $465,367 | Grant | Trans-NIH Recovery Act Research Support: This study uniquely combines technologies from the fields of acoustics and MRI imaging to address a research question that has vexed manual therapists for over a century. The work will deepen the research of the parent grant by allowing further investigat | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| EMORY UNIVERSITY | $551,083 | Grant | Trans-NIH Recovery Act Research Support: Mechanisms of Meditation Mechanisms of Meditation This project will significantly expand the scope of our NCCAM-funded R01 Project entitled ?Mechanisms of Meditation? (R01AT004698-01). It adds an innovative naturalistic observation method to assess the ef | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $13,004 | Grant | Trans-NIH Recovery Act Research Support: The unfolded protein response (UPR) triggers multiple pathways to allow cells to respond to stress conditions that target the endoplasmic reticulum (ER). The ER is a cellular organelle where secretory and membrane proteins are synthesized and modified and | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| PURDUE UNIVERSITY | $265,350 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION: This application is submitted in response to Notice Number NOT-OD-09-058: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications. In this application, additional funds are sought to expand the scope of rese | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $280,050 | Grant | Trans-NIH Recovery Act Research Support: Inflammation, Obesity and Risk of Colorectal Adenomas This project will test the central hypothesis that systemic cytokines and adipokines or local biomarkers of inflammation predict risk for colorectal adenomas and low apoptosis within the normal colonic | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UMDNJ-ROBERT WOOD JOHNSON MEDICAL SCHOOL | $24,841 | Grant | Trans-NIH Recovery Act Research Support: The research award was for two summer students. This is the second summer of the award. During this period, the high school student (Jaya Kanduri) who previously worked in the laboratory returned for a second year. She worked on improving the expressio | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $251,520 | Grant | Trans-NIH Recovery Act Research Support: Plasma C-Reactive Protein (CRP) level is a biomarker that predicts future risk of cardiovascular disease. The specific aims of R01HL088531 are to (1) comprehensively explore patterns of rare variation at CRP by resequencing individuals selected from two | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | $128,397 | Grant | Trans-NIH Recovery Act Research Support: Cell magnetophoresis is a cell motion induced by the magnetic field in electrolyte solutions. During the current funding period (ending 01/31/08) we have used Cell Tracking Velocimetry (CTV) to compare effects of binding of various commercial immunomagnet | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $139,473 | Grant | Trans-NIH Recovery Act Research Support: In our previous application, we designed novel and rational clinical trials, based on our preclinical studies, combining gemcitabine with radiation for the treatment of patients with advanced head and neck cancers and pancreatic cancer that have produced | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $225,051 | Grant | Trans-NIH Recovery Act Research Support: The recognition that prostate cancer clusters within families has led many research teams including our own to collect families with multiple cases of prostate cancer for linkage studies. Unfortunately, despite the collection and analysis of a large numbe | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $236,483 | Grant | Trans-NIH Recovery Act Research Support: Statistical Methods in Current Cancer Research: ARRA-funded Administrative Supplement. The broad, long-term objectives of this research are the developments of statistical methods for the designs and analysis of clinical and epidemiological cancer studies | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $311,817 | Grant | Trans-NIH Recovery Act Research Support: Supported by the parent grant ?Clinical and Cost-effectiveness of HPV vaccination in the U.S.?, we have developed a series of empirically calibrated models capable of assessing the costs, benefits, and cost-effectiveness of primary prevention (vaccination | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| THE WASHINGTON UNIVERSITY | $148,960 | Grant | Trans-NIH Recovery Act Research Support: GENETIC SUSCEPTIBILITY TO CERVICAL CANCER | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $343,705 | Grant | Trans-NIH Recovery Act Research Support: The MUC1 heterodimeric oncoprotein is aberrantly expressed at high levels in over 90% of human breast cancers. The MUC1 N-terminal subunit (MUC1-N) is a mucin-type glycoprotein that disrupts cell-cell and cell-extracellular matrix interactions. The MUC1 C | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $175,840 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this application is to request support that was lost from the original budget needed to perform the studies outlined in Specific Aim #3, as well as additional support to augment our proposed studies outline in Specific Aim 3 of our parent g | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $44,053 | Grant | Trans-NIH Recovery Act Research Support: Inactivation of the adenomatous polyposis coli (APC) tumor suppressor triggers the development of the vast majority of colorectal carcinomas. Our goal is to dissect the function(s) of APC, and the molecular and cellular consequences of APC inactivation, i | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| SOUTH CAROLINA RESEARCH FOUNDATION | $139,059 | Grant | Trans-NIH Recovery Act Research Support: TELECONFERENCE GROUP: BREAST CANCER IN AFRICAN AMERICANS The purpose of the supplement request is to increase enrollment in our current randomized clinical trial and to increase our capacity for data analysis. Our trial investigates the effectiveness of | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| UNIVERSITY OF MARYLAND | $376,297 | Grant | Trans-NIH Recovery Act Research Support: 'The ongoing project (CA197331) as well as the new work proposed in this competitive revision application addresses many important public health concerns including providing drugs to treat several cancers including malignant melanoma. This work also provi | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $143,474 | Grant | Trans-NIH Recovery Act Research Support: PTEN is a tumor suppressor and the first phosphatase identified to be frequently mutated/deleted somatically in a variety of human cancers. Substantial evidence supports that loss of PTEN promotes the development of human cancer. PTEN normally serves to r | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $530,833 | Grant | Trans-NIH Recovery Act Research Support: Most prospective epidemiologic studies have shown that a diet that is low in folate and high in alcohol significantly increases the risk of breast cancer (BC), making the methyl (or one-carbon)-deficient diet one of the few modifiable risk factors for BC. | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| MAYO CLINIC ARIZONA | $152,000 | Grant | Trans-NIH Recovery Act Research Support: The studies of the parent grant (CA112442, Eosinophil Recruitment and Activation in Solid Tumors) leading to this Supplement have provided important insights as to the magnitude and extent of tumor associated eosinophilia. More importantly, these studies | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| UNIVERSITY OF NEW MEXICO | $147,045 | Grant | Trans-NIH Recovery Act Research Support: Surprisingly, a great deal of ecological evidence shows that prognosis of melanoma is better in areas with high ground level ultraviolet radiation. An individual-level analysis of survival in a Connecticut melanoma cohort also shows that those who develop | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC. | $334,000 | Grant | Trans-NIH Recovery Act Research Support: Ovarian cancer causes more deaths each year among North American women than any other gynecologic cancer. The etiology is poorly understood. Although highly penetrant mutations in BRCA1 and BRCA2 are known to significantly increase ovarian cancer risk, su | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| PURDUE UNIVERSITY | $126,860 | Grant | Trans-NIH Recovery Act Research Support: Breast cancer is the most commonly diagnosed cancer in woman and the second leading cause of deaths among women worldwide. More than 200,000 individuals will be diagnosed this year and 40,000 will die from it. Although the exact cause of the breast cancer | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| MAYO CLINIC | $302,191 | Grant | Trans-NIH Recovery Act Research Support: Women who carry inactivating mutations in the BRCA1 and BRCA2 genes in their germline are at significantly elevate risk of breast and ovarian cancer. Because of the identification of these mutations by clinical genetic testing many mutation carriers are a | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| THE VANDERBILT UNIVERSITY | $977,864 | Grant | Trans-NIH Recovery Act Research Support: This 2-year Administrative Supplement application is submitted in response to the American Recovery and Reinvestment Act (ARRA) of 2009, NCI-Activities to Promote Research Collaboration (NCI-APRC). The parent grant of this application is the NCI-funded R0 | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $588,582 | Grant | Trans-NIH Recovery Act Research Support: 1)It will allow us to enhance our ability to detect associations of genetic variants with susceptibility to having mutations in RB1 gene and cause RB disease. 2)Will allow us to hire additional personnel and train them in the current state of the art tech | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF ARIZONA | $315,523 | Grant | Trans-NIH Recovery Act Research Support: Ovarian cancer has the highest mortality of all gynecologic cancers, and 70% of women with ovarian cancer die of their disease within 5 years. Survival is high with early stage disease, yet ovarian cancer is not| usually detected earlier than Stage III or | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $320,000 | Grant | Trans-NIH Recovery Act Research Support: Near-infrared fluorescence (NIRF)-based optical imaging of human cancers has several advantages over standard imaging techniques in that it is extremely sensitive, inexpensive, and robust; involves no harmful radiation; and allows real-time visualization. | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $156,413 | Grant | Trans-NIH Recovery Act Research Support: PhotoSensitizer Nanoparticle Aptamer Conjugate Therapy (SNACT) is an application of targeted photodynamic therapy (PDT) involving the administration of a photosensitizer (PS) encapsulated in aptamer-bound nanoparticles (NP), followed by light activation o | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| WAYNE STATE UNIVERSITY (INC) | $263,311 | Grant | Trans-NIH Recovery Act Research Support: We propose to define in greater detail the structural-functional relationship of galectin-3 as its relates to cellular localization, cell growth, apoptosis resistance, cell-cell recognition, angiogenesis, tumor growth and hematogenous spread of tumor cell | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $396,640 | Grant | Trans-NIH Recovery Act Research Support: This NCI-APRC proposal is a new joint effort between Dr. Young Whang, the PI of the parent grant G?Regulation of androgen receptor by HER-2 and Ack1 tyrosine kinaseG?, and Dr. Alex Tropsha, who focuses on optimizing virtual screening approaches for drug d | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| GEORGETOWN UNIVERSITY (THE) | $291,096 | Grant | Trans-NIH Recovery Act Research Support: Colorectal cancer (CRC) is one of the most commonly diagnosed cancers and the third leading cause of cancer death among Chinese Americans. Older Chinese Americans have the lowest CRC screening rate in the U.S. Physician recommendation is the strongest pre | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF PITTSBURGH THE | $197,708 | Grant | Trans-NIH Recovery Act Research Support: This competitive revision is in response to the Notice Number (NOT-OD-09-058) and Notice Title: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications, for the parent grant (R01CA121105) entitled SMAC in chemoprevention | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $369,994 | Grant | Trans-NIH Recovery Act Research Support: The goal of this research is to identify novel susceptibility genes for lung cancer using a systematic genome- wide association-based approach. To achieve this goal, we are applying a two-stage design. This proposal builds upon an extensive resource of lu | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| EAST CAROLINA UNIVERSITY | $598,592 | Grant | Trans-NIH Recovery Act Research Support: The project is a supplement to the parent grant R01 CA-122704-02. The goals of this Diversity Supplement project are to develop and pilot test cognitive-behavioral coping skills training (CST) protocols tailored for partnered and unpartnered African Ameri | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE | $219,187 | Grant | Trans-NIH Recovery Act Research Support: The Epstein Barr virus is an oncogenic herpesvirus that is intimately involved in a number of malignancies in humans. The genetic basis of EBV associated oncogenesis is the concerted action of EBV latency associated genes and varying cellular genetic alte | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF ROCHESTER | $188,471 | Grant | Trans-NIH Recovery Act Research Support: The Aim of this proposal is to implement internet enabled tissue banking and patient annotation software for the collection of esophageal cancer specimens and data at the University of Rochester and the University of Pittsburgh. Our goal is to create a co | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | $309,000 | Grant | Trans-NIH Recovery Act Research Support: Autophagy is a catabolic process whereby cellular organelles and bulk cytoplasm are targeted for degradation in lysosomes. Recent evidence suggests that autophagy is a survival pathway necessary to sustain mammalian viability during periods of starvation, | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| UNIVERSITY OF MARYLAND | $349,914 | Grant | Trans-NIH Recovery Act Research Support: Skin cancer is an important health problem and is a major cause of cancer worldwide. Skin cancer chemoprevention by diet-derived agents is an important area of study. In the present proposal we study the ability of green tea polyphenols to regulate epi | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $528,993 | Grant | Trans-NIH Recovery Act Research Support: The parent grant for this ARRA supplemental funding is National Cancer Institute R01 grant 1R01CA131386-01A1. The major focus of the parent R01 grant was to develop and evaluate the effects of Spanish and English language versions of a personally tailored | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | $19,158 | Grant | Trans-NIH Recovery Act Research Support: The objective of the parent is grant to study the inhibition of lung carcinogenesis by green tea polyphenols and the synergistic action when used in combination with atorvastatin. The inhibitory action and the mechanisms involved will be thoroughly invest | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| RESEARCH TRIANGLE INSTITUTE | $212,181 | Grant | Trans-NIH Recovery Act Research Support: The hypotheses of our original application are: (a) nAChR partial agonists possessing high affinity for nAChRs and varying degrees of agonist and antagonist efficacies and nAChR subtype selectivity will be useful pharmacological tools for studying the nA | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF OREGON | $361,259 | Grant | Trans-NIH Recovery Act Research Support: Supplement Topic Area: Accelerating the Science (ACC) The overarching goals of the proposed and ongoing research in the parent grant are to determine which aspects of sensory and language processing and related neural systems are most dependent on and mo | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $142,068 | Grant | Trans-NIH Recovery Act Research Support: People with sensorineural hearing loss experience difficulties understanding speech in noisy environments and often complain that music sounds distorted or unpleasant. Both of these deficits may be attributed to the functional effects of damage to cochlea | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $76,190 | Grant | Trans-NIH Recovery Act Research Support: Complex Sound Analysis In Normal And Impaired Listeners ARRA This award is a supplement to a parent Project whose purpose is to characterize the temporal processing deficits in audition that emerge early in the aging process, and to differentiate these de | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF FLORIDA | $372,947 | Grant | Trans-NIH Recovery Act Research Support: The imaging instrumentation requested with the supplemental support was purchased, installed, and calibrated, and is currently being used to acquire data. Data obtianed with the new instrumentaiton to date have been included in a manuscript that is in th | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| ALLEGHENY-SINGER RESEARCH INSTITUTE | $254,171 | Grant | Trans-NIH Recovery Act Research Support: Chronic middle ear infections including otitis media with effusion and recurrent otitis media are two of the most common reasons that children visit a doctor, receive antibiotics and undergo general anesthesia and surgery. These infections are caused by s | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $140,209 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The goal of this project is to extend our knowledge of the neural mechanisms that underlie the integration of information from different sensory modalities and their transformation into motor commands to generate gaze | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $352,093 | Grant | Trans-NIH Recovery Act Research Support: Sensory cells, called hair cells are responsible for converting mechanical signals into electrical signals. An series of actin filled microvillae of increasing height sit atop the sensory hair cell being deflected by mechanical stimulation. This deflectio | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $909,393 | Grant | Trans-NIH Recovery Act Research Support: A substantial number of military personnel who have served in Iraq (Operation Iraqi Freedom; OIF) and Afghanistan (Operating Enduring Freedom; OEF) report alcohol misuse and symptoms of posttraumatic stress disorder (PTSD) following their return home, sim | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $998,950 | Grant | Trans-NIH Recovery Act Research Support: A large body of both human and animal data support the idea that adolescent behaviors can have life-long effects on an individual. This sensitivity may derive, in part, from the dramatic developmental changes in brain function that are taking place at thi | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| HEPREGEN | $910,000 | Grant | Trans-NIH Recovery Act Research Support: Animal studies are insufficient for predicting human liver responses due to significant species-specific differences in liver functions. Therefore, a plethora of in vitro human liver models have been developed over the last three decades to supplement tes | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| RAND CORPORATION. THE | $499,847 | Grant | Trans-NIH Recovery Act Research Support: We suggest statistical techniques to overcome two threats to the external validity of a randomized controlled trial and apply our techniques to the example of the Women's Health Initiative Estrogen + Progestin study. New methods to detect and correct for | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $738,783 | Grant | Trans-NIH Recovery Act Research Support: The central focus of this proposal explores how to fill a technological gap - the detection of specific A oligomers in living subjects. The development of new techniques for measuring specific A oligomers in living individuals will enable us to investigat | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $996,214 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (05) Comparative Effectiveness Research and specific Topic 05-CA-104* Comparative Effectiveness Research on Cancer Treatment. Effectiveness of prostate cancer treatment has been previously evaluated by Marko | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF CONNECTICUT | $983,204 | Grant | Trans-NIH Recovery Act Research Support: Tumors vary greatly in the course of disease and in how they respond to specific therapies. Molecular diagnostic methods that can be used to classify tumors and predict their behavior have enormous potential to both increase the effectiveness of treatment | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| PURDUE UNIVERSITY | $998,945 | Grant | Trans-NIH Recovery Act Research Support: The researcher will develop analytical imaging capabilities with complementary nanoparticle probes to measure the viscoelastic properties of cells and tissues in a noninvasive manner. These capabilities will be applied toward understanding biomechanical f | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| DYNAMIC CLINICAL SYSTEMS, INC. | $967,083 | Grant | Trans-NIH Recovery Act Research Support: The specific aims of this project are to build on this previous work and momentum to: 1. Design patient-reported outcomes (PRO) system functionality and processes for breast cancer survivors, and develop high-priority system features, including: (A) at-ho | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (15) Translational Science and specific Challenge Topic, 15-CA-112: Cancer Cell Energy Metabolism and Cancer Causation The molecular events that covert normal cells into tumor cells alter cellular metabolism | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| VIRGINIA COMMONWEALTH UNIVERSITY | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: The proposal 'Amphetamine acts as a Molecular Stent in the Dopamine Transporter' addresses the specific problem of amphetamine addiction, and introduces drug development strategies for detoxification of drug abusers. The central hypothesis rests on data s | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | $734,224 | Grant | Trans-NIH Recovery Act Research Support: Phenotypic Markers for Smoking Cessation: Impulsive Choice and Impulsive Action This application addresses broad Challenge Area (01): Behavior, Behavioral Change, and Prevention and specific high-priority Challenge Topic 01-AA-101 Identifying Phenotypic M | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $496,068 | Grant | Trans-NIH Recovery Act Research Support: The present application An Animal Model of Therapeutic Self-Medication for Neuropathic Pain addresses the broad Challenge Area (15) Translational Science and specific Challenge Topic, 15-DA-112: New Models and Measures in Preclinical Chronic Pain Research | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| BAYLOR COLLEGE OF MEDICINE | $732,684 | Grant | Trans-NIH Recovery Act Research Support: Medication development for substance dependence. abstract:This application addresses broad NIH Challenge Area 04: Clinical Research and specific Challenge Topic 04-DA-101: Evaluation of novel, rationalized poly-pharmacotherapeutic treatment strategies for | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| WRIGHT STATE UNIVERSITY | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: The Primary Specific Aim of this proposal is to compare, using drug abstinence as the measure, the effectiveness of an episodic care model (TAU) and a continuous care model (LTRM) of substance abuse treatment among drug-dependent adults entering a commun | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| OHIO UNIVERSITY | $847,098 | Grant | Trans-NIH Recovery Act Research Support: This research proposes an alternative approach for characterizing neuron intrinsic active properties, and indentifying a neuron's complete set membrane currents, individual-neuron-by-individual neuron. The key idea is that measuring the response of indiv | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| ST. JUDE CHILDREN'S RESEARCH HOSPITAL | $788,091 | Grant | Trans-NIH Recovery Act Research Support: This proposal meets the requirements of two major Challenge Areas within Clinical Research, 'Prevention of otitis media' (04-DC101), and 'Develop novel methods and address key questions in mucosal immunology' (04-AI-101). Otitis media caused by Streptococ | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| ROCKEFELLER UNIVERSITY FACULTY AND STUDENTS CLUB INC, THE | $451,106 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area 11, entitled Regenerative Medicine. The specific Challenge Topic is 11-DC-101, Hair Cell Regeneration and Maintenance. Deafness and lesser degrees of hearing impairment have an enormous impact on modern soci | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $954,397 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (03) Biomarker Discovery and Validation, and specific Challenge Topic, 03-DE-101: Development, Refinement, or Validation of Biomarkers Relevant to Oral or Craniofacial Disorders. The goal of this proposed st | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF CONNECTICUT | $968,726 | Grant | Trans-NIH Recovery Act Research Support: There has been a remarkable growth in translational research organized around the screening, brief intervention and referral services (SBIRT) concept, with numerous clinical trials conducted, new screening tests developed, and implementation programs eval | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $849,987 | Grant | Trans-NIH Recovery Act Research Support: This application addresses the broad Challenge Area (13) Smart Biomaterials - Theranostics and the specific Challenge Topic, 13-DE-102: Dental Resin Composites and Caries. With a majority of the more than 100,000 million dental restorative treatments perf | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF OREGON | $889,301 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (06) Enabling Technologies, and specific Challenge Topic 06-DE-102 Structural and Molecular Atlases of Craniofacial Development. We propose to construct a developmental atlas for the craniofacial skeleton of | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF PITTSBURGH THE | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: This project will address the lack of randomized controlled studies and comparative effectiveness research in bariatric surgery by utilizing a three arm randomized trial to compare medical and surgical treatments for Type 2 diabetes. Understanding more c | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| MAYO CLINIC | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area, 04-DK-103: Develop Novel Approaches to Understand and Treat Functional Disorders. We plan to determine the role of diet and how genotype contributes to the development of functional GI and motility disorder | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $981,458 | Grant | Trans-NIH Recovery Act Research Support: Chronic kidney diseases take one of the highest tolls on human health. Steroid-resistant nephrotic syndrome (SRNS) is a rare disease that constitutes the second most frequent cause of ESKD in children and young adults. No curative treatment is available. | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| NORTH CAROLINA STATE UNIVERSITY | $992,501 | Grant | Trans-NIH Recovery Act Research Support: Drug-induced liver injury (DILI) is the major adverse drug event that leads to regulatory actions on drugs, including failure to approve, restricted indications, and withdrawal from the marketplace. The most problematic form of DILI is ?idiosyncratic?, m | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF CINCINNATI | $997,824 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (15) Translational Science and specific Challenge Topic 15-DK-106: Translating basic hematology concepts. Haploinsufficiency of ribosomal protein (rp) genes underlies the inherited marrow failure syndromes D | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $426,471 | Grant | Trans-NIH Recovery Act Research Support: The application addresses the broad Challenge Area (15) Translational Science and Specific Challenge Topic, 15-ES-101; Effects of environmental exposures on phenotypic outcomes using non-human models. This application will apply non-human modeling to exam | Health and Human Services, Department of / National Institutes of Health | 9/26/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $1,047,500 | Grant | Trans-NIH Recovery Act Research Support: Novel Approaches to Evaluate Carbon Nanotube Health Impacts. Our work will provide a broad understanding of how inhaled ultrafine or nanosized particles in the form of single-walled carbon nanotubes (SWCNTs) produce effects through physical or chemical p | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $875,802 | Grant | Trans-NIH Recovery Act Research Support: Discovery of Small Molecule MBT Domain Antagonists-ARRA DISCOVERY OF SMALL MOLECULE MBT DOMAIN ANTAGONISTS Abstract: Multicellular organisms have evolved elaborate mechanisms to enable the differential and cell-type specific expression of genes. This ca | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: Most existing technologies can only measure the properties of a population of cells and not the properties of individual cells. C. elegans is unique among model organisms in that the complete cell lineage is known, enabling one to identify each nucleus in | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| MAYO CLINIC | $974,131 | Grant | Trans-NIH Recovery Act Research Support: This application addresses Challenge Area #15:Translational Science and Specific Challenge Topic, 15-HD-102: Pelvic Pain. We propose to characterize the pain with menses and noncyclic pelvic pain in women with uterine leiomyomas at baseline and following | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| OHIO STATE UNIVERSITY, THE | $856,711 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (12): Science, Technology, Engineering, and Mathematics Education (STEM), and specific Challenge Topic (12-OD-101*): Efficacy of Educational Approaches toward Promoting STEM Competencies. The proposed large- | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $990,163 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (10) Information Technology for Processing Health Care Data and specific Challenge Topic, 10-HD-102: Data Archiving and Dissemination. The sharp increase in the sophistication of social science data systems | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| BROWN UNIVERSITY IN PROVIDENCE IN STATE OF RI AND PROVIDENCE PLANTATIONS | $950,949 | Grant | Trans-NIH Recovery Act Research Support: During this past quarter, several additional research sessions using the Light-Weight Robot III (LWRIII) robot were performed. A 3D target placement system was created and utilized in sessions to allow for statistical analysis of performance in target ac | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| MED STAR HEALTH RESEARCH INSTITUTE | $735,365 | Grant | Trans-NIH Recovery Act Research Support: The research focuses on the critical need to develop patient level interventions to increase the representation of African Americans in cancer trials. The prurpose is to design and assexss the impact of culturally appropriate educational video, developed | Health and Human Services, Department of / National Institutes of Health | 9/26/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $953,855 | Grant | Trans-NIH Recovery Act Research Support: HOPE Accounts for Women - ARRA This award addresses broad Challenge Area (09): Health Disparities and specific Challenge Topic 09-MD-101: Creating Transformational Approaches to Address Rural Health Disparities. HOPE Accounts for Women is an innovative | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF PITTSBURGH THE | $992,870 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this clinical trial is to study the effectiveness of a weight management intervention for pediatric obesity adapted for a low income, racially and ethnically diverse disparity population on child BMI in a sample of 140 obese children ages 2 | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| NEW YORK UNIVERSITY | $990,944 | Grant | Trans-NIH Recovery Act Research Support: This Spanish-Language computerized counseling intervention will deliver evidence-based treatment support to a highly vulnerable Latino population. We will evaluate effectiveness on medication and clinic visit adherence and biological outcomes. WE will ide | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF ILLINOIS | $982,922 | Grant | Trans-NIH Recovery Act Research Support: The central aim of the study, is to differentiate the alterations in cognitive and affective circuitry in pediatric bipolar disorder (PBD) and attention deficit hyperactivity disorder (ADHD) relative to typically developing operations. PBD and ADHD are th | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $1,352,934 | Grant | Trans-NIH Recovery Act Research Support: We seek support to recruit an extremely promising young radiochemist to join a substantial group of neuroscience investigators. Our candidate would be a new faculty member, does not have a current tenure-track appointment, has outstanding research trainin | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $691,400 | Grant | Trans-NIH Recovery Act Research Support: The Biochemistry Program at Dartmouth Medical School performs a critical role in the biomedical enterprise through training the next generation of physicians and scientists, advancing knowledge across multiple disciplines, and developing faculty leaders i | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CONNECTICUT | $765,417 | Grant | Trans-NIH Recovery Act Research Support: This proposal from the University of Connecticut seeks funding to support re-opening a previous faculty search in the broad area of NMR-based structural biology that was suspended to economic conditions. The faculty recruit will be expected to establish a | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| NORTH CAROLINA STATE UNIVERSITY | $671,500 | Grant | Trans-NIH Recovery Act Research Support: The Department of Genetics at North Carolina State University was founded in 1958 and has established a long and esteemed record of contributions to quantitative genetics using model organisms. The Department of Genetics is housed in the four-story South | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $1,041,830 | Grant | Trans-NIH Recovery Act Research Support: This P30 application seeks to provide resources to recruit Dr. Eric Schmidt to lead the Molecular Physiology and Imaging Core (MPIC) in the Division of Pulmonary Sciences and Critical Care Medicine. The Division is based at the University of CO Denver and | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| SEATTLE BIOMEDICAL RESEARCH INSTITUTE | $866,084 | Grant | Trans-NIH Recovery Act Research Support: The liver has a capacity to sequester activated CD8+ T cells from the circulating pool, due in part to the expression of adhesion molecules on the hepatic sinusoidal endothelium. However, both the detailed mechanisms responsible for this sequestration and | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $949,500 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of the proposal is to determine the mechanisms responsible for the super agonist activity of cytokine/anti-cytokine mAb complexes. The biological activity of many administered cytokines can be greatly boosted by first binding the cytokine | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| GEORGIA HEALTH SCIENCES UNIVERSITY RESEARCH INSTITUTE, INC. | $735,000 | Grant | Trans-NIH Recovery Act Research Support: The paradigm that inflammation stimulates adaptive immunity is well established. Paradoxically, mounting evidence reveals that some forms of inflammation create local suppression, particularly in tissues subjected to chronic inflammation caused by persist | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| ALBANY MEDICAL COLLEGE | $785,000 | Grant | Trans-NIH Recovery Act Research Support: The overall objective of this proposed project is to understand the mechanisms responsible for enhanced susceptibility to Streptococcus pneumoniae that follows influenza infection. Despite being a recognized clinical problem that causes many, if not the m | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| GEORGIA HEALTH SCIENCES UNIVERSITY RESEARCH INSTITUTE, INC. | $735,000 | Grant | Trans-NIH Recovery Act Research Support: Repertoire of antigen receptors (TCRs) on T cells is shaped by interactions between TCRs and MHC molecules bound with peptides of self and non-self origin. In thymus, these interactions promote differentiation of T cells with TCRs with low/intermediate af | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| ST. JUDE CHILDREN'S RESEARCH HOSPITAL | $1,083,581 | Grant | Trans-NIH Recovery Act Research Support: In an effort to develop new targets for antibacterial drug discovery, we recently discovered that Gram positive bacteria use a unique and essential pathway to synthesize their membrane phospholipids mediated by two gene products, PlsX and PlsY. This pathw | Health and Human Services, Department of / National Institutes of Health | 8/18/2009 |
| IOWA STATE UNIVERSITY OF SCIENCE AND TECHNOLOGY | $1,109,229 | Grant | Trans-NIH Recovery Act Research Support: Bacterial microcompartments are large subcellular structures composed of metabolic enzymes encapsulated within a protein shell built from multiple subunits. They are widespread among bacteria, functionally diverse, play vital metabolic roles, are linked t | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| DUKE UNIVERSITY | $780,000 | Grant | Trans-NIH Recovery Act Research Support: The emergence of serum antibody responses only after early cellular immune responses have suppressed HIV replication has led to doubts regarding the importance of humoral immunity in controlling HIV infections. Nonetheless, rare, broadly cross-reactive an | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY M | $765,000 | Grant | Trans-NIH Recovery Act Research Support: The goal of this study is to better understand the body's immune response to worms that invade human tissues. Results may lead to better approaches for developing vaccines against worms and to new concepts for how to treat autoimmune and allergic diseases | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $589,852 | Grant | Trans-NIH Recovery Act Research Support: critical obstacle to molecular and genomic classification of primary melanoma has been the requirement to provide prognostic measures (i.e. Breslow thickness) and related histologic parameters in formalin-fixed, paraffin-embedded (FFPE) biospecimens, wher | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| UNIVERSITY OF ILLINOIS | $157,000 | Grant | Trans-NIH Recovery Act Research Support: Role of cellular senescence in mammary cancer prevention by rexinoids The main goal of this grant proposal is to determine the role of cellular senescence (CS) as a potential intermediate (surrogate) endpoint in mammary cancer prevention | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF NEBRASKA | $545,682 | Grant | Trans-NIH Recovery Act Research Support: Epstein-Barr virus (EBV) infection is an important cause of lymphomas in AIDS patients, especially in central nervous system lymphoma (CNS lymphoma). EBV transforms human primary B cells in vitro, the process of which is believed to resemble EBV transform | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| CANCER PREVENTION INSTITUTE OF CALIFORNIA | $508,687 | Grant | Trans-NIH Recovery Act Research Support: Associations of socioeconomic status (SES) with breast cancer risk and survival are well described. The risk of breast cancer is lower in women of lower SES, while survival after breast cancer in these groups is poorer for certain racial/ethnic groups, in | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF WASHINGTON | $647,400 | Grant | Trans-NIH Recovery Act Research Support: Silencing RNA (siRNA) is of considerable current interest in biological research because it can elicit potent, target specific knockdown of any mRNA, creating a useful and proven genetic surrogate tool. However, a key problem for effective application of | Health and Human Services, Department of / National Institutes of Health | 8/12/2009 |
| CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | $651,550 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Breast cancer is responsible for the second overall cause of cancer-related deaths among women. Despite this profound health risk, Immunotherapy for breast cancer has not been adequately developed as an integral part o | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $983,640 | Grant | Trans-NIH Recovery Act Research Support: Improving Care Continuity in Drug Abuse Treatment Drug users generally benefit from continuing treatment in an outpatient program following their stay in a residential treatment setting. This project will set up linkages between residential and outpatient | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $1,180,976 | Grant | Trans-NIH Recovery Act Research Support: Organismal and Genetic Networks in Drug Reward and Reinforcement - ARRA The goal of this project is to examine genetic pathways involved in addiction by using a mouse model of initial sensitivity to cocaine. The project involves behavioral, pharmacokinet | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $840,831 | Grant | Trans-NIH Recovery Act Research Support: Schizophrenia is a major debilitating brain disorder that affects 1% of the world's population. There is a 90% prevalence rate of comorbid nicotine addiction in schizophrenic patients leading to high morbidity and mortality rate in this vulnerable populat | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $924,135 | Grant | Trans-NIH Recovery Act Research Support: Innovative strategies for tobacco cessation must be considered. Currently, there are 44 million smokers in the US and 1.2 billion smokers world-wide. Although 22 million smokers try to quit smoking each year, only 3-5% are successful in becoming sustaine | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| OREGON SOCIAL LEARNING CENTER | $1,144,341 | Grant | Trans-NIH Recovery Act Research Support: The 'Preventing Drug Abuse & HIV/AIDS in Delinquent Youths: An Integrated Intervention' study is a 2-year randomized trial of a family-centered preventive intervention for adolescent boys involved in the juvenile justice system who are at high risk for ch | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| UNIVERSITY OF ROCHESTER | $667,606 | Grant | Trans-NIH Recovery Act Research Support: Neurological symptoms with methamphetamine (METH) toxicity of the nigrostriatal system, both in rodent models and in drug abusers, are associated with neuroinflammation, a fundamental reaction to brain injury characterized by activated microglia and astro | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF MIAMI | $1,073,458 | Grant | Trans-NIH Recovery Act Research Support: Given the severe and often life-long consequences linked to drug abuse, criminal involvement, and risky sexual behavior in childhood and adolescence, early intervention is considered by many to be crucial to halt the progression of these devastating probl | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| BROWN UNIVERSITY IN PROVIDENCE IN STATE OF RI AND PROVIDENCE PLANTATIONS | $1,117,259 | Grant | Trans-NIH Recovery Act Research Support: Cannabis use disorders are a significant public health concern that disproportionately affect youth. Although promising psychosocial interventions are being developed, most youth do not benefit from these interventions alone. In light of the clinical dema | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $376,800 | Grant | Trans-NIH Recovery Act Research Support: as defined in the award description. PI has left the University. Final report will be submitted next qtr | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $739,625 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to define the function of the basic helix-loop-helix transcription factor Hand2 during mammalian lower jaw development. Our hypothesis is that Hand2 contributes to the development of most lower jaw structures by establishing a | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $964,704 | Grant | Trans-NIH Recovery Act Research Support: The first specific aim is designed to investigate whether mina biogenesis is essential for liver regeneration. This will be done by specific knockdown of critical components of Dicer in mina processing and Ago2 in the RNA Induced Silencing Complex (RISC). | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $697,950 | Grant | Trans-NIH Recovery Act Research Support: The studies will elucidate the key role of Toll-like receptor 4 and kidney dendritic cells in the induction of the inflammatory phenotype of the kidney during acute injury. These results will be relevant because they are expected to lead to clinical trial | Health and Human Services, Department of / National Institutes of Health | 8/18/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $832,881 | Grant | Trans-NIH Recovery Act Research Support: Our goal is to understand molecular mechanisms involved in the diurnal regulation of plasma lipids. We observed that plasma triglyceride and cholesterol in apoB-lipoproteins show diurnal rhythms. These rhythms are changed when animals are subjected to foo | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| TEXAS BIOMEDICAL RESEARCH INSTITUTE | $1,684,480 | Grant | Trans-NIH Recovery Act Research Support: The escalating obesity epidemic is now one of the most significant threats to human health in the 21st century. In this project, we will employ a novel approach to the empirical identification of novel candidate genes influencing body mass index (BMI), in | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $695,928 | Grant | Trans-NIH Recovery Act Research Support: ADPKD is the most prevalent inherited renal disease, accounting for 4% of the ESRD population. Detection of renal cysts utilizing renal imaging has been the most common method of diagnosis of this disease however, cyst appearance is often delayed with aff | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | $750,975 | Grant | Trans-NIH Recovery Act Research Support: It is paramount in medical imaging to measure, compare, calibrate, register and analyze potentially deformed organ shapes with high accuracy and fidelity. However, this is extremely difficult due to the complicated shape of human organs. Different organs | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| NEW YORK UNIVERSITY (INC) | $544,362 | Grant | Trans-NIH Recovery Act Research Support: Quantitative MRI of Microstructure and Iron Homeostasis in ADHD Brain Attention-Deficit/Hyperactivity Disorder is the most studied condition in child psychiatry, reflecting its high prevalence and significant lifelong impairment. Despite progress in docu | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| WASHINGTON UNIVERSITY, THE | $721,375 | Grant | Trans-NIH Recovery Act Research Support: The overall aim of this project is to develop novel conformal small-animal irradiator, suitable for studying genetic markers of radiation response and radiobiological models at therapeutic dose levels. There has been a revolution in functional imaging tha | Health and Human Services, Department of / National Institutes of Health | 4/30/2009 |
| UNIVERSITY OF PITTSBURGH THE | $723,556 | Grant | Trans-NIH Recovery Act Research Support: Regenerative medicine approaches for the reconstitution of missing or injured tissues and organs involves the use of scaffolds, cells, and bioactive molecules. The use of biologic scaffolds seeded with cells is a common approach and several applications | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $820,050 | Grant | Trans-NIH Recovery Act Research Support: Embryonic stem cell (ESC) differentiation is a potentially powerful approach for generating a renewable source of cells for regenerative medicine. It is known that the microenvironment greatly influences ESC differentiation and self-renewal. Most biologic | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| UNIVERSITY OF MIAMI | $735,000 | Grant | Trans-NIH Recovery Act Research Support: Knowledge of the mechano-electrochemical signals around the cells and solute transport within a tissue is crucial to understanding cell biology, tissue growth and remodeling in vivo or in vitro. Bioreactors are essential for tissue engineering in vitro as | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| BROWN UNIVERSITY IN PROVIDENCE IN STATE OF RI AND PROVIDENCE PLANTATIONS | $661,445 | Grant | Trans-NIH Recovery Act Research Support: Using micro-molded agarose, we have developed a novel and surprisingly easy system for creating 3D micro-tissues with complex shapes such as rods, toroids and honeycombs that are scaffold-free. 3D micro-tissues made in this way may have applications in re | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $771,736 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): When environmental exposure assessment studies provide feedback to the lay public, the resultant communications generally focus on the exposure assessment itself (e.g., serum levels) and not the relationship of the exp | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| SMITH-KETTLEWELL EYE RESEARCH INSTITUTE, THE | $409,480 | Grant | Trans-NIH Recovery Act Research Support: The fundamental goal of perception is to infer the structure of the world through an interpretation of temporal and spatial regularities in sensory stimulation that map onto structures in the environment such as objects and surfaces. The goal of this pro | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON | $715,981 | Grant | Trans-NIH Recovery Act Research Support: Area V4 is a key component of primate visual cortex that is involved in many aspects of 'intermediate' processing including higher-order shape processing, color constancy, and attention. V4 performs more complex computations than lower areas V1 or V2, but | Health and Human Services, Department of / National Institutes of Health | 6/19/2009 |
| THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK INC | $651,665 | Grant | Trans-NIH Recovery Act Research Support: Many proteins undergo post-translational acetylation of the -amino group of lysine. Acetylation of histones and transcription factors, in competition with other modifications occurring on the same lysines, is well-established as a regulator of gene expres | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $651,553 | Grant | Trans-NIH Recovery Act Research Support: The proposed project should have a positive impact on human health; elucidating molecular mechanisms that regulate spermatogonial development may well lead to treatments and cures for male infertility, provide new targets for contraceptive development, as | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| RAND CORPORATION, THE | $984,908 | Grant | Trans-NIH Recovery Act Research Support: Recent breakthroughs in the pharmaceutical treatment of viral sexually transmitted infections (STI's) have dramatically improved the health and well-being of the infected. However, the treatment of such incurable infectious diseases raises uniquely import | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| WASHINGTON UNIVERSITY, THE | $335,516 | Grant | Trans-NIH Recovery Act Research Support: The household production model remains the lens through which many social scientists and virtually all economists view time allocation within households. Adults' investments in their own human capital require time as well as money (e.g., going to classes; | Health and Human Services, Department of / National Institutes of Health | 7/28/2009 |
| NATIONAL DEVELOPMENT AND RESEARCH INSTITUTES, INC. | $988,096 | Grant | Trans-NIH Recovery Act Research Support: The project will greatly advance scientific understanding of why and how marginalized heterosexual black men often seek out and engage in various forms of sexual behavior with multiple partners, and whether and how condoms and safer sex messages are inter | Health and Human Services, Department of / National Institutes of Health | 8/24/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $765,335 | Grant | Trans-NIH Recovery Act Research Support: The proposed project should have a positive impact on human health because elucidating molecular mechanisms that regulate sperm stem cell development will lead to treatments and cures for male infertility, provide new targets for contraceptive development | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF WASHINGTON | $444,599 | Grant | Trans-NIH Recovery Act Research Support: The objective of this proposed NIH RO1 is to expand the scope of a recently funded NIH grant titled 'A longitudinal MRI Study of Infants at Risk for Autism,' - (RO1 HD055741) and acquire 3-D chemical images of 6, 12 and 24 month-old siblings of children w | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $952,010 | Grant | Trans-NIH Recovery Act Research Support: Our major purpose for this project is to identify novel biomarkers of risk for VTE among approximately 3,500 plasma metabolites detected by mass spectrometry based analysis. Work began on this project September 30, 2009 and the expected outcome is to acco | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF SOUTH FLORIDA | $972,615 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (07): Enhancing Clinical Trials, and specific Challenge Topic, 07-OD(ORDR)-101* Library of Standardized Patient Registry Questions. The primary objective of this applicat | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| GALENEA CORPORATION | $1,063,611 | Grant | Trans-NIH Recovery Act Research Support: Schizophrenia is a devastating mental illness that affects approximately 1% of the global population. Symptoms of schizophrenia can be grouped into three categories: positive symptoms, such as hallucinations; negative symptoms, such as social isolation a | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| CHILDRENS HOSPITAL OF PHILADELPHIA | $500,000 | Grant | Trans-NIH Recovery Act Research Support: Developing a Community-Based ASD Research Registry This application addresses Broad Challenge Area 05 (Comparative Effectiveness Research) & Specific Challenge Topic 05-MH-104 (Building ASD Registries for Use in Comparative Effectiveness Research). Enroll | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| NEW YORK UNIVERSITY (INC) | $979,357 | Grant | Trans-NIH Recovery Act Research Support: This application addresses NIMH broad Challenge Area (04) Clinical Research and specific challenge topic 04-MH-102: refining categories of clinical phenotypes for mental health research purposes. We propose an innovative study aimed at refining and valida | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| VIRGINIA COMMONWEALTH UNIVERSITY | $975,612 | Grant | Trans-NIH Recovery Act Research Support: This project from Virginia Commonwealth University proposes to address the challenging goal of translating best practices into the community and subsequently improving health outcomes in minority, underserved and vulnerable populations by building researc | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $722,753 | Grant | Trans-NIH Recovery Act Research Support: Patient navigation (PN) is a community-centered approach that can potentially reduce health disparities by enhancing access to care at an earlier stage of the disease continuum for underserved populations, such as racial/ethnic minorities or individuals w | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $998,648 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (05) Comparative Effectiveness Research and specific Challenge Topic, 05-CA-104*: Comparative Effectiveness Research on Cancer Treatment. We propose to address two distinct but related challenges: (1) develo | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF WASHINGTON | $953,661 | Grant | Trans-NIH Recovery Act Research Support: Adjuvant endocrine therapy improves outcomes for estrogen receptor positive (ER+) early stage breast cancer. Recently aromatase inhibitors (AIs) have been shown to provide incremental benefit over tamoxifen. In neoadjuvant endocrine therapy studies, a t | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $538,595 | Grant | Trans-NIH Recovery Act Research Support: The proposed project advances efficient and effective health research, and ultimately the quality of health care provided to the public, by removing unnecessary barriers to that research created by inappropriate and inconsistent privacy regulations. Moreo | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $937,549 | Grant | Trans-NIH Recovery Act Research Support: The relationship between the position of gene loci in the nucleus and cell physiology has emerged as an important facet of cell biology. Chromosomal translocations occur when double stranded breaks in DNA are repaired by incorrectly fusing one end of the | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $958,863 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (05): Comparative Effectiveness Research and specific Challenge Topic 05-DA-102: Treatment of Substance Abuse and Related Health Consequences Using Web-Based Technologies. Web-based videoconferencing technol | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| NORTHWESTERN UNIVERSITY | $419,375 | Grant | Trans-NIH Recovery Act Research Support: Secretory IgA (SIgA) is an important mediator of mucosal immunity. Strategies that boost SIgA production in the airways will confer benefit to patients that have become susceptible to infections caused by airborne pathogens. Our studies point to a novel m | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| WASHINGTON UNIVERSITY, THE | $414,848 | Grant | Trans-NIH Recovery Act Research Support: Dendritic cells (DCs) play an essential role initiating and guiding immune responses toward intestinal pathogens and non-pathogens. The intestine contains a population of DCs that are uniquely positioned at the interface of the host with the environment. | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $402,625 | Grant | Trans-NIH Recovery Act Research Support: The immunological of the mucosal extracellular matrix, or stroma, in innate and adaptive immunity has not been critically evaluated and is poorly understood. In view of the newly appreciated importance of the stroma in immunological cross-talk and regula | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF PITTSBURGH THE | $389,459 | Grant | Trans-NIH Recovery Act Research Support: The ability of functional magnetic resonance imaging (fMRI) to detect brain function non-invasively with high spatial resolution opens great opportunities to advance our understanding of brain organization and function. Currently, most fMRI techniques are | Health and Human Services, Department of / National Institutes of Health | 4/29/2009 |
| SEATTLE CHILDREN'S HOSPITAL | $772,496 | Grant | Trans-NIH Recovery Act Research Support: Treatment as usual and peer engagement in teens with High Functioning Autism -- Epidemiological studies now indicate that the prevalence of autism and related disorders may be as high as 1 in 150 children with nationwide estimates of the overall c | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| CHILDREN'S RESEARCH INSTITUTE | $594,802 | Grant | Trans-NIH Recovery Act Research Support: This project is focused on discovering the mechanisms which act during early brain development to cause mental retardation in Down syndrome (DS). The Aims include experiments to uncover why more inhibitory interneurons are produced in the cerebral cortex | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $810,357 | Grant | Trans-NIH Recovery Act Research Support: The overall propose is to understand the initial steps in stem cell differentiation. The expected outcome is to learn more information that will allow us to i) develop new markers to allow us to classify and purify unique populations of stem cell, ii) ide | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| UNIVERSITY OF WASHINGTON | $907,417 | Grant | Trans-NIH Recovery Act Research Support: Here we investigate a novel antimicrobial approach using the metal gallium (Ga) as a 'Trojan horse' to disrupt bacterial Fe metabolism. Ga has a nearly identical ionic radius as Fe, and many biologic systems are unable to distinguish Ga from Fe. Ga disr | Health and Human Services, Department of / National Institutes of Health | 5/30/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $1,531,681 | Grant | Trans-NIH Recovery Act Research Support: The Specific Aims of the project are[?] Evaluate the new system in vivo to: A) investigate visualization of RF lesions during and following an AF ablation in an animal model and B) carry out a small patient study to prove visualization of scar (MI-related | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | $817,494 | Grant | Trans-NIH Recovery Act Research Support: Circadian and daily rhythms regulate many aspects of physiology and behavior. Although a growing number of studies suggest that circadian disruptions may render organisms more susceptible to infection and cancer, the molecular links between the circadian | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF CHICAGO, THE | $843,762 | Grant | Trans-NIH Recovery Act Research Support: The recognition of the hierarchies of genetic pathways coordinating heart development remains incomplete, in part because of the difficulties to identify the critical cis-acting sequences that are required for the regionalized expression of genes during c | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF CHICAGO, THE | $780,000 | Grant | Trans-NIH Recovery Act Research Support: Acute lung injury, sepsis, lung inflammation, and ventilator-induced lung injury are life-threatening conditions associated with lung vascular barrier dysfunction, which may lead to pulmonary edema. Increased levels of atrial natriuretic peptide (ANP) in | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| MAYO CLINIC | $1,479,657 | Grant | Trans-NIH Recovery Act Research Support: Arterial disease (arteriosclerosis) is accelerated in the presence of hypertension, a major cardiovascular risk factor that affects more than 65 million people in the USA, resulting in health care costs of ~$110 billion annually. Despite significant advan | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| CHILDRENS HOSPITAL OF PHILADELPHIA | $958,249 | Grant | Trans-NIH Recovery Act Research Support: The proposed research will study a novel approach for treating heart valve disease via the use of heart valve replacements with trileaflet polyurethane prostheses that are endothelial seeded using blood outgrowth endothelial cells (BOEC). We will investig | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $1,591,641 | Grant | Trans-NIH Recovery Act Research Support: Persons with abdominal obesity have a high prevalence of endothelial dysfunction, arterial stiffness, and left ventricular diastolic function, each an early marker of cardiovascular disease (CVD). Though diet and exercise are primary treatments for obesit | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| DUKE UNIVERSITY | $13,613,141 | Grant | Trans-NIH Recovery Act Research Support: Millions of Americans develop chest pain suggestive of coronary heart disease each year and often require non-invasive diagnostic testing. However, currently available tests are imprecise, robust evidence regarding optimal test choice is limited, and test | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| ST. JUDE CHILDREN'S RESEARCH HOSPITAL | $851,732 | Grant | Trans-NIH Recovery Act Research Support: We have made important progress on the Tol2 project since the revised application and the supplemental data were submitted in 2008. The most significant advance is the demonstration of germ line transmission of remobilized Tol2 transposons following thein | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| TEXAS A & M UNIVERSITY SYSTEM HEALTH SCIENCE CENTER RESEARCH | $991,694 | Grant | Trans-NIH Recovery Act Research Support: The medical office visit is the foundation of medical care and one of the most important professional activities of primary care physicians who are often the only source of mental health services for older adults. Evidence continues to show that the gap b | Health and Human Services, Department of / National Institutes of Health | 5/12/2009 |
| WASHINGTON UNIVERSITY, THE | $1,026,000 | Grant | Trans-NIH Recovery Act Research Support: The long-range objective of the proposed research is to refine, evaluate, and disseminate an Internet-based intervention to prevent eating disorders (EDs) and comorbidities in college-age women. EDs are highly prevalent among college women and can lead to | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| UNIVERSITY OF PUERTO RICO-MEDICAL SCIENCES CAMPUS | $1,000,452 | Grant | Trans-NIH Recovery Act Research Support: This proposal will focus on HIV infection studies with HIV-ADA and will not compare different HIV isolates. Primary isolates will be performed in future studies. The scope is limited to cystatins B/C and cathepsin B. Includes studies of MDM and superna | Health and Human Services, Department of / National Institutes of Health | 6/19/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $833,417 | Grant | Trans-NIH Recovery Act Research Support: Schizophrenia is a devastating psychiatric illness arising in part from subtle defects in brain development. The Disrupted-In-Schizophrenia-1 (DISC1) gene is an example of a strong candidate gene for studying the pathogenesis of schizophrenia and associat | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $761,158 | Grant | Trans-NIH Recovery Act Research Support: Although a wide range of environmental stimuli have been proposed to play a role in the pathogenesis of autism spectrum disorders, many of these stimuli have in common the ability to alter immune function. Since cytokines mediate the immune response, are | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $1,412,032 | Grant | Trans-NIH Recovery Act Research Support: This collaborative application is submitted in response to RFA MH-09-171. The root causes of autism remain unknown, limiting efforts to understand disease heterogeneity, diagnose cases, and prevent and treat disease. Epidemiological findings have repeated | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF IOWA, THE | $748,412 | Grant | Trans-NIH Recovery Act Research Support: This study is designed to improve access to appropriate behavioral services for young children (ages 1 to 6 years) with autism spectrum disorders. The major research goal is to evaluate the effectiveness and efficiency of conducting behavioral treatment f | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| BRANDEIS UNIVERSITY | $787,100 | Grant | Trans-NIH Recovery Act Research Support: The sympathetic nervous system innervates a number of targets, including the heart, and sympathetic activity is a critical regulator of cardiac function. Sympathetic neurons form noradrenergic synapses onto heart cells resulting in excitation of myocyte f | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| CORNELL UNIVERSITY, INC | $691,673 | Grant | Trans-NIH Recovery Act Research Support: The organization of the neural network, or Central Pattern Generator (CPG), that organizes locomotor behavior in the rodent spinal cord, is poorly understood. We propose that the function of the CPG network depends not only on the pattern of synaptic conn | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $798,135 | Grant | Trans-NIH Recovery Act Research Support: This award was funded to support our ongoing effort to develop MRI image analysis software, called DtiStudio/MriStudio. This is a family of software to analyze MR images. The software was developed through collaboration between Drs. Mori and Miller and it | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY | $851,448 | Grant | Trans-NIH Recovery Act Research Support: It is currently estimated that in 2050, the cost of treating the aging population for dementia caused by various neurodegenerative diseases will consume the entire gross national product of the industrialized countries. Consequently, effective preventive | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC. | $750,000 | Grant | Trans-NIH Recovery Act Research Support: This study addresses the mechanisms of regulation of neuronal gap junctions (electrical synapses) during development and traumatic brain injury and the role of gap junctions in traumatic brain injury. This research has clinical importance given that gap j | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $769,776 | Grant | Trans-NIH Recovery Act Research Support: Approximately 40,000 Americans are diagnosed with brain tumors each year, with15-35% being glioblastoma multiforme (GBM), an aggressive primary brain tumor that has defied all existing therapeutic modalities. Treatment of brain tumors normally begins with | Health and Human Services, Department of / National Institutes of Health | 9/20/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $888,380 | Grant | Trans-NIH Recovery Act Research Support: Spinal cord injury disrupts the connections between the brain and spinal cord, often resulting in the loss of sensory and motor function below the lesion site. The most important reason for such permanent functional deficits is the failure of injured axon | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $600,000 | Grant | Trans-NIH Recovery Act Research Support: This proposal entitled 'Dynamic Regulation of shank3 and ASD' examines the molecular mechanisms that link human mutations of shank3 with Autism Spectrum Disorder (ASD). Mutations of the open reading frame of shank3 have been identified in multiple cases o | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| NORTHWESTERN UNIVERSITY | $991,237 | Grant | Trans-NIH Recovery Act Research Support: The goal of the proposed project is to develop a community driven, open source Disease Ontology (DO) that can be used to link disparate datasets through disease concepts. We will provide a computable structure of inheritable, environmental and infectious | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| MISSOURI SYSTEM, UNIVERSITY OF | $148,868 | Grant | Trans-NIH Recovery Act Research Support: The health benefits of the proposed research include the potential to discover new and effective glycotherapeutics to fight bacterial infections in humans. Other benefits to the biomedical community include the discovery of new effective synthetic strateg | Health and Human Services, Department of / National Institutes of Health | 5/11/2009 |
| WASHINGTON UNIVERSITY, THE | $144,236 | Grant | Trans-NIH Recovery Act Research Support: The overarching goal of the proposed study is to improve communication among clinicians, patients, and family caregivers about a diagnosis of dementia. Specific aims. 1) Characterize physician, patient, and companion behaviors during a dementia diagnosis | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $126,690 | Grant | Trans-NIH Recovery Act Research Support: White Matter Lesions (WML) of aging are commonly seen on MRI scans and show as diffuse or punctate lesions with a predilection to affect periventricular areas. Several studies have shown that WML are associated with increased risk of falls in older adults | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| UNIVERSITY OF ARKANSAS SYSTEM | $142,000 | Grant | Trans-NIH Recovery Act Research Support: Long lasting vaccination memory that is effective in both healthy and at-risk individuals is an important public health goal. This work seeks to improve the quality and persistence of such immune memory by adding drugs that decrease the death of immune c | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $164,000 | Grant | Trans-NIH Recovery Act Research Support: This project will use specimens and epidemiological data -?collected from a series of field gonorrhea intervention projects conductied in Baltimore.-? The project will develop a method for typing gonococcal isolates (organisms) which uses proteins found o | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| OREGON STATE UNIVERSITY | $146,200 | Grant | Trans-NIH Recovery Act Research Support: A herpesvirus, referred to as LHV-4, was found to be associated with a disease affecting over half of the 55 rabbits on a farm near Anchorage, Alaska. About 28 percent of the affected animals died or were euthanized because of the severity of the illness. | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| TORREY PINES INSTITUTE FOR MOLECULAR STUDIES, INC. | $450,000 | Grant | Trans-NIH Recovery Act Research Support: Novel class of peptidomimetics, and cyclic peptidomimetics have become appealing targets for the design of therapeutic agents with increased pharmacological activities. Therapeutic potential and demand of opioid analgesics have initiated numerous amounts | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF RHODE ISLAND | $149,000 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Food insecurity and overweight pose significant risks to the optimal development of low income children. While insufficient consumption of high-quality nutritious food and/or excessive consumption of poor quality foods | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $153,334 | Grant | Trans-NIH Recovery Act Research Support: By early childhood, children who will later develop a primary psychotic disorder are already demonstrating many of the deficits that are closely associated with the disease in the adult. For example, even though diagnostic symptomotology may be a decade o | Health and Human Services, Department of / National Institutes of Health | 5/27/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $166,064 | Grant | Trans-NIH Recovery Act Research Support: Although state and local mandatory helmet laws have become widespread in the US, there is almost no information on whether such regulations actually decrease injuries from bicycle-related accidents. The first aim is to use pooled, annual, hospital-level d | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| KESSLER FOUNDATION INC | $153,854 | Grant | Trans-NIH Recovery Act Research Support: Of 5.7 million stroke survivors in the United States, up to 90% may have visuospatial deficits, linked to poor rehabilitation outcomes, an increase of clinical morbidity, and impairments in competent driving, shopping, sports, computer/internet use, and o | Health and Human Services, Department of / National Institutes of Health | 9/10/2009 |
| UNIVERSITY OF PITTSBURGH THE | $151,500 | Grant | Trans-NIH Recovery Act Research Support: Pulmonary hypertension (PH) is a life-threatening condition which can occur in association with many diseases, including chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). PH occurring in isolation, with characteristic | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| UNIVERSITY OF TEXAS HEALTHCARE AT TYLER | $70,500 | Grant | Trans-NIH Recovery Act Research Support: Terminal airway occlusion by hypersecretive mucus is a major manifestation in chronic obstructive pulmonary disease (COPD). In the cystic fibrosis lung, a genotype of COPD, hyperactive ENaC has already been proved to be a fundamental mechanism for dehydra | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| UNIVERSITY OF WASHINGTON | $156,000 | Grant | Trans-NIH Recovery Act Research Support: Although Parkinson's disease (PD) was first described in 1817, the cause still remains obscure. A large body of experimental evidence indicates that destruction of dopaminergic neurons may result from a series of inter-related mechanisms involving microgl | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| THE JACKSON LABORATORY | $174,000 | Grant | Trans-NIH Recovery Act Research Support: Rett syndrome is a severe neurological disorder causing progressive loss of motor and language skills in girls. There is no cure for the disease, and existing treatments are very limited. Recent studies have demonstrated that mutations in the gene encodi | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $155,100 | Grant | Trans-NIH Recovery Act Research Support: This project represents an opportunity to develop protective treatments for glutaric aciduria that may be relevent to other childhood metabolic disorders.Glutaryl-coenzyme A dehydrogenase (GCDH) deficiency is an inherited disorder of lysine and tryptophan | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY OF CHICAGO, THE | $79,639 | Grant | Trans-NIH Recovery Act Research Support: Spontaneous and ENU-induced mouse mutants are a tremendously valuable resource for their ability to model human disease. The study of these mutants has provided new insights into basic clinically relevant biological mechanisms, which would not have been a | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| DUKE UNIVERSITY | $156,000 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Deep brain stimulation (DBS) treats the cardinal symptoms of Parkinson's disease (PD) including bradykinesia, rigidity, and tremor, and the efficacy of DBS is strongly dependent on finding stimulation parameters (fr | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF LA VERNE | $203,538 | Grant | Trans-NIH Recovery Act Research Support: The proposed research will enhance our understanding of how and when endocrine-disrupting chemicals (EDCs) affect the immune system, and will form the basis for assessment of prenatal immune impacts of EDCs and for strategies to prevent immune disease cau | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF TOLEDO, THE | $218,250 | Grant | Trans-NIH Recovery Act Research Support: Defects in intermediate filament (IF) proteins that normally form stress resistant networks in cells, and contribute to their architectural integrity and cellular function, are linked to a number of human disease conditions, including congenital defects.. | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF MISSOURI SYSTEM | $229,519 | Grant | Trans-NIH Recovery Act Research Support: The combination of high resolution assays in genomics with microscopic imaging has been used for the detection of complex chromosomal rearrangements, a significant but difficult problem in prenatal and postnatal diagnosis, birth defect detection and cance | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $229,708 | Grant | Trans-NIH Recovery Act Research Support: Interactions of C-Reactive Protein Isoforms With Oxidized Lipid Membranes Abstract: C-reactive protein (CRP) rises in serum in response to inflammation and is a promising marker for identifying patients at risk for cardiovascular disease (CVD). Elevated C | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| CAL POLY CORPORATION | $210,000 | Grant | Trans-NIH Recovery Act Research Support: Sexual reproduction in diploid eukaryotes involves formation of haploid gametes through a specialized cell division known as meiosis. Fusion of two haploid gametes at fertilization recreates diploidy in the next generation. Accurate segregation of chromos | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| CORPORATION OF HAVERFORD COLLEGE, THE | $213,530 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Few processes in biology hold the same degree of fascination as the transformation of a single fertilized egg into a fully differentiated adult organism. What are the genetic mechanisms that physically build and shape | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| CORPORATION OF HAVERFORD COLLEGE, THE | $172,054 | Grant | Trans-NIH Recovery Act Research Support: The overarching goal of this project is to better understand the ways in which cognitive and emotional self-regulation are disrupted in depression. When faced with unfavorable situations, people with depression are unable to implement adaptive behavior ch | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| DREXEL UNIVERSITY | $418,074 | Grant | Trans-NIH Recovery Act Research Support: The liver is the largest organ in the body. It is involved in a myriad of metabolic processes required for body homeostasis and can also detoxify harmful chemicals. The liver receives blood from the hepatic portal vein and the hepatic artery. The hepatic | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $423,500 | Grant | Trans-NIH Recovery Act Research Support: Alternative splicing is an important level of gene regulation and a major source of proteome diversity in humans and other mammals. At least 74% of human genes express multiple mRNAs through alternative splicing of exons or exon segments. Deregulation of | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| UNIVERSITY OF TEXAS HEALTHCARE AT TYLER | $188,823 | Grant | Trans-NIH Recovery Act Research Support: Research on lymphostromal interactions during the thymic aging--Aging causes thymic involution, which decreases thymic lymphopoiesis and exhausts the na+?ve T-cell pool, constricting diversity of T-cell receptor repertoire and inducing immunosenescence. H | Health and Human Services, Department of / National Institutes of Health | 5/20/2009 |
| UNIVERSITY OF SOUTH FLORIDA | $319,077 | Grant | Trans-NIH Recovery Act Research Support: Parkinson's Disease (PD) affects about 1 million individuals in the United States. In addition to the typical motor dysfunction, PD also affects cognition and vision, even in early stages of the disesse, impairing instrumental activities of daily living s | Health and Human Services, Department of / National Institutes of Health | 8/12/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $337,240 | Grant | Trans-NIH Recovery Act Research Support: Racial and ethnic health disparities abound, with decreased quality of health care in these underserved communities. The reasons for these health inequities are complex and multi-layered. As noted by the Institute of Medicine, there are historic and conte | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $418,000 | Grant | Trans-NIH Recovery Act Research Support: How variant signaling strength of the B cell antigen receptor (BCR) complex is transformed into biochemical signals is not well understood. A growing body of evidence indicates that lipid rafts function as platforms for signalling through the BCR. Bright | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $443,857 | Grant | Trans-NIH Recovery Act Research Support: This is a two-year award for an exploratory project whose overall goal is to understand the rules for protein-RNA recognition. There are two aims to the proposal. The first aim seeks to identify the proteins that can bind the RNA tetraloop RNA motifs from | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON | $415,250 | Grant | Trans-NIH Recovery Act Research Support: Francisella tularensis is a gram-negative bacterium and one of the top-priority agents ('Class A') most likely to pose a potential risk to national security. Although much has been learned from a mouse model using an attenuated strain of Francisella, Fran | Health and Human Services, Department of / National Institutes of Health | 5/19/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $431,750 | Grant | Trans-NIH Recovery Act Research Support: Influenza virus must hijack proteins present within the cells of the human mucosa in order to reproduce in infected individuals. A detailed understanding of the mucosal cell proteins required to support viral replication as well as those which are mobiliz | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| TRANSLATIONAL GENOMICS RESEARCH INSTITITUE, THE | $404,142 | Grant | Trans-NIH Recovery Act Research Support: With a 5-year survival rate of less than 4% pancreatic cancer is the fourth leading cause of cancer death in the United States. Current chemotherapy and radiation therapy are largely ineffective in the treatment of this disease. Surgical treatment offers | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $261,313 | Grant | Trans-NIH Recovery Act Research Support: Ovarian cancer remains a common and lethal disease. Most women diagnosed with ovarian cancer are destined to die from advanced, refractory disease, even though most also respond well to initial therapy. At least 80% of human cancers depend on aberrant sig | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $391,475 | Grant | Trans-NIH Recovery Act Research Support: Research on therapeutic community (TC) process is critically needed. While meta-analysis has supported the effectiveness of TCs, it has also shown that effect sizes are often modest (Pearson & Lipton, 1999). It is likely that a better understanding of TC | Health and Human Services, Department of / National Institutes of Health | 5/11/2009 |
| OREGON RESEARCH INSTITUTE | $426,116 | Grant | Trans-NIH Recovery Act Research Support: This research project is developing and evaluating the use of Ecological Momentary Assessment (EMA) to study the ways early adolescents may be influenced by their peers. EMA is a method of collecting self-report information in real-time and in natural set | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF PITTSBURGH THE | $398,874 | Grant | Trans-NIH Recovery Act Research Support: The overall goals of this research are to improve clinical decision making in Pediatric Acute Liver Failure (PALF) by (1) developing quantitative models of prognosis and disease progression, and (2) using them to calibrate optimization models of the trans | Health and Human Services, Department of / National Institutes of Health | 6/10/2009 |
| MEDICAL COLLEGE OF WISCONSIN, INC., THE | $418,000 | Grant | Trans-NIH Recovery Act Research Support: MMicroRNAs are endogenous regulatory RNAs that bind to the 3G??-untranslated region (3G??-UTR) of target mRNAs through imperfect complementarities and reduce the level of target protein expression. Numerous studies have begun to reveal a critical and wid | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| UNIVERSITY OF ROCHESTER | $433,731 | Grant | Trans-NIH Recovery Act Research Support: Our long term goal is to study the mechanism of neurodegeneration induced by environmental neurotoxicants. This proposal is submitted to investigate gene-environment interactions in the pathogenesis of Parkinson's disease mediated through the mitochondria | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $996,908 | Grant | Trans-NIH Recovery Act Research Support: Advanced, metastatic prostate cancer that progresses following hormone (androgen) suppression, has no known cure, and contributes to substantial morbidity and mortality. This proposal aims to categorize advanced castration-resistant prostate cancers into | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $1,328,025 | Grant | Trans-NIH Recovery Act Research Support: Acute respiratory failure is a heterogeneous disorder that results in more than 300,000 Americans requiring admission to an intensive care unit for invasive mechanical ventilatory support each year. Though acute respiratory failure is a pulmonary disorder | Health and Human Services, Department of / National Institutes of Health | 5/22/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $788,564 | Grant | Trans-NIH Recovery Act Research Support: Glucocorticoids (GCs), the adrenal steroids secreted during stress, can compromise the ability of neurons to survive necrotic neurological insults. These deleterious effects have often been viewed as counterbalanced by the benefits of the anti-inflammator | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| COLORADO STATE UNIVERSITY | $73,500 | Grant | Trans-NIH Recovery Act Research Support: This present project proposes a quantitative examination of the factors that impact program completion among a population of students in the first campus drug court program in the U.S. called Back on TRAC (BOT). The BOT program addresses a growing need to | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| WASHINGTON STATE UNIVERSITY | $149,500 | Grant | Trans-NIH Recovery Act Research Support: Opioids such as morphine are the most effective treatment for pain. Unfortunately, this opioid analgesia is limited by the development of tolerance with repeated administration. Cannabinoids also have been shown to have analgesic effects, but this antinoc | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $82,000 | Grant | Trans-NIH Recovery Act Research Support: The current project is a B-Start grant that is being used to collect preliminary data to submit a R01. Specifically, hallucinogens are generally considered to be physiologically safe (i.e., they do not result in physiological dependence nor do they cause | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $870,252 | Grant | Trans-NIH Recovery Act Research Support: The aim of this proposal is to establish zebrafish (Danio rerio) models suitable for in vivo studies of certain processes of atherogenesis. It is widely accepted that hypercholesterolemia leads to lipid accumulation in arteries, which in turn induces vasc | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF CHICAGO, THE | $224,392 | Grant | Trans-NIH Recovery Act Research Support: The goal is to understand the evolution of microRNAs (miRNAs), the coevolution between miRNAs and their targets, and the role miRNA-target interactions play in the expression divergence between closely related species of Drosophila. miRNAs are small regul | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $102,770 | Grant | Trans-NIH Recovery Act Research Support: This supplement request outlines our plan to purchase new imaging equipment to accelerate the pace of discovery, and to broaden the approach described in the original grant proposal, which will lead to new discoveries and result in high quality publicatio | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| CALIFORNIA INSTITUTE OF TECHNOLOGY | $90,165 | Grant | Trans-NIH Recovery Act Research Support: We seek support from the Recovery Act Funds for Administrative Supplements to supplement ongoing NIH grant GM059940, which bears the title, Mechanism of Mitotic Exit in Budding Yeast . The proposed supplement will allow us to investigate in greater deta | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $99,994 | Grant | Trans-NIH Recovery Act Research Support: Each cell independently interprets extracellular signals to decide its fate. An outstanding question in developmental biology is how these decisions are coordinated across the developing tissue primordium to produce a functional organ of appropriate size. | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $278,381 | Grant | Trans-NIH Recovery Act Research Support: The parent grant to this supplement investigates how origins of DNA replication are epigenetically regulated using Drosophila as a model . A DNA consensus for origins has not emerged in multi-cellular eukaryotes. Instead, evidence suggests that epigenetic | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| UNIVERSITY OF CHICAGO, THE | $191,600 | Grant | Trans-NIH Recovery Act Research Support: In two previous stages of this project, both funded by the National Institute of General Medical Sciences and carried out successfully, we developed GeneWays, a completely automated system that efficiently distills information about molecular interactions | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $200,415 | Grant | Trans-NIH Recovery Act Research Support: Mutation in the gene for the ABCA3 transporter cause a variety of lung diseases that result in either death in the immediate newborn period or chronic lung disease in children and into adulthood. We have created mouse models of the human ABCA3 mutations | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | $188,455 | Grant | Trans-NIH Recovery Act Research Support: Description (provided by the applicant): Coagulation factors V (FV) and factor VIII (FVIII) are both secreted glycoproteins that share pivotal roles in both hemostasis and thrombosis. Although many secreted proteins (referred to as cargo) are believed to | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $225,202 | Grant | Trans-NIH Recovery Act Research Support: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is a genetic form of cardiomyopathy, which is typically characterized by right but also recently left ventricular dysfunction, fibrotic/fatty replacement of the ventricle and ventricular a | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| WAYNE STATE UNIVERSITY (INC) | $17,705 | Grant | Trans-NIH Recovery Act Research Support: The parent grant of this application is focused on 1) determining the mechanisms mediating the repsonses to stimulation of NTS adenosine receptor subtypes and 2) the role of adenosine receptors in NTS in modulating cardiovascular responses from descending | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $163,560 | Grant | Trans-NIH Recovery Act Research Support: In this administrative supplement request, we propose to accelerate a subset of our proposed tasks for this grant. In particular, we propose to: 1. Accelerate the software engineering activities in creating a reference implementation of FEATURE and up | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $998,813 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (15) Translational Science and specific Challenge Topic, 15-HL-104: Characterize the role and effects of the respiratory and/or intestinal microbiota on the presence and clinical phenotype of lung disease. T | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| WASHINGTON UNIVERSITY, THE | $2,456,842 | Grant | Trans-NIH Recovery Act Research Support: This application responds to the NHLBI 'Grand Opportunities' RC2 topic, 'Large-scale DNA Sequencing and Molecular Profiling of Well-Phenotyped NHLBI Cohorts.' We will use whole genome resequencing to identify genetic changes relevant for the pathogenesis | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF WASHINGTON | $447,450 | Grant | Trans-NIH Recovery Act Research Support: It is proposed to expand the capability to perform modern multi-nuclear solid state NMR experiments at the University of Washington by replacing an obsolete, home-built single r.f. channel 500 MHz. NMR console with a commercial triple channel solid state | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| YALE UNIVERSITY | $92,429 | Grant | Trans-NIH Recovery Act Research Support: We request funds to purchase multiple instruments that will increase the throughput capacity of the DNA Analysis Facility on Science Hill (DAFSH) at Yale University. Currently DAFSH is functioning as a medium-throughput, fee-for-service and non-profit Cor | Health and Human Services, Department of / National Institutes of Health | 5/04/2009 |
| UNIVERSITY OF PITTSBURGH THE | $2,941,900 | Grant | Trans-NIH Recovery Act Research Support: The representation of minorities in public health and biomedical research still lags behind that of whites. This represents an ongoing challenge to the validity and generalizability of research findings, which consequently contributes to disparities in h | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | $651,550 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Uveal melanoma is a rare malignancy of the eye. Survival rates are poor. Metastatic disease occurs frequently and invariably results in death. At present there is insufficient evidence to support the use of any systemi | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION | $402,875 | Grant | Trans-NIH Recovery Act Research Support: We believe that there are a number of facts, in addition to our preliminary data; that make a study of the developmental immunotoxicity of atrazine compelling. One, atrazine is both the most heavily used single herbicide employed in USA agriculture at th | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $454,248 | Grant | Trans-NIH Recovery Act Research Support: Adaptation and survival to strenuous environmental conditions are evolutionary conserved mechanisms that allow organisms to produce progeny. In general, adaptation to stress promotes the repair of protein and DNA damage and must occur rapidly. Thus, trans | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $484,000 | Grant | Trans-NIH Recovery Act Research Support: This project aims to define correlates of immune protection to HIV infection by assessing two poorly defined functions of HIV-specific T cells. Due to the extreme variability of HIV, the ability of T cells to cope with HIV antigenic diversity as well as t | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| THE VANDERBILT UNIVERSITY | $387,344 | Grant | Trans-NIH Recovery Act Research Support: A growing body of evidence suggests a causal relationship between the accumulation of classically activated macrophages in adipose tissue and development of insulin resistance in obesity. The molecular mechanisms regulating adipose tissue macrophage (ATM) | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| COLORADO STATE UNIVERSITY | $400,008 | Grant | Trans-NIH Recovery Act Research Support: HIV protease is a well established target for the inhibition of viral replication and there are a handful of FDA- approved drugs that are being used to weigh down HIV protease activity. However, these drugs are exclusively targeted to the catalytic site o | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF WASHINGTON | $429,000 | Grant | Trans-NIH Recovery Act Research Support: Sexually transmitted infections (STIs) have a huge impact on public health. Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infections globally, and is the most prevalent sexually transmitted diseases in the United State, wit | Health and Human Services, Department of / National Institutes of Health | 7/23/2009 |
| MONTANA STATE UNIVERSITY, INC | $391,875 | Grant | Trans-NIH Recovery Act Research Support: For this project, we will construct a live vaccine that aims at preventing human salmonellosis. Salmonella enterica is a disease that causes a variety of food and water-borne illnesses, such as gastroenteritis and typhoid fever. It can infect a wide range | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $413,210 | Grant | Trans-NIH Recovery Act Research Support: Cytomegalovirus (CMV) is a ubiquitous pathogen that causes significant morbidity and mortality in immunocompromised populations. Currently, there is no effective vaccine against CMV. Development of a vaccine, particularly for women of child-bearing age, i | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| BAYLOR RESEARCH INSTITUTE, THE | $156,000 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Hepatitis C virus (HCV) infection represents a significant global health-care problem, which is forecasted to become worse in the coming years. In the developed world, infection with HCV is responsible for 50-75% of al | Health and Human Services, Department of / National Institutes of Health | 5/28/2009 |
| DUKE UNIVERSITY | $353,375 | Grant | Trans-NIH Recovery Act Research Support: The goal of these investigations is to elucidate the role of microparticles (MPs) as a key source of nuclear antigens in systemic lupus erythematosus (SLE) and characterize these structures as components of pathogenic immune complexes (ICs). MPs are small | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| TUFTS MEDICAL CENTER, INC. | $471,506 | Grant | Trans-NIH Recovery Act Research Support: Lyme disease is the most common vector borne disease in the United States. Although antibiotic therapy is clinically effective in treating the symptoms of Lyme disease for patients early in the course of disease, a significant number of patients who rece | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| AR CHILDRENS HOSPITAL RESEARCH INSTITUTE | $202,125 | Grant | Trans-NIH Recovery Act Research Support: There are multiple mechanisms by which bacteria elicit an inflammatory response at mucosal sites; however, a pathway mediated by neuropeptides has received little attention but may be equally as important in the induction of the inflammatory response by b | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $426,401 | Grant | Trans-NIH Recovery Act Research Support: The tegument region of herpes viruses is located between the outer surface of the capsid and the inner surface of the envelope and is made up of approximately 20 different proteins. Recent evidence suggests that the tegument is not a static structure and | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| ALBANY MEDICAL COLLEGE | $433,625 | Grant | Trans-NIH Recovery Act Research Support: In addition to mediating activation of CD4 T helper cells, antigenic peptideG??major histocompatibility complex (MHC) class II complexes, consisting of an alpha and beta chain) transduce signals leading to antigen presenting cell activation. Using well-ch | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| UNIVERSITY OF ALABAMA | $389,314 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Herpes simplex virus type 1 (HSV-1) is a widespread human pathogen that causes a diverse array of diseases ranging from recurrent cold sores and genital lesions to blindness and encephalitis. The pathogenesis of HSV-1 | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| TEXAS A&M UNIVERSITY SYSTEM,THE | $436,000 | Grant | Trans-NIH Recovery Act Research Support: Non-typhoidal Salmonella, including serotype Typhimurium (STm) are food-borne bacterial pathogens that cause ~1.4 million cases of diarrheal disease annually in the United States and hundreds of millions of cases worldwide. In the intestine, STm induces a | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| PURDUE UNIVERSITY | $419,375 | Grant | Trans-NIH Recovery Act Research Support: A hallmark of infection with positive strand RNA viruses is the impressive intracellular membrane rearrangements induced within host cells to facilitate replication of their viral genomes. This project will use a multidisciplinary approach to investigate | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| UNIVERSITY OF PITTSBURGH THE | $416,625 | Grant | Trans-NIH Recovery Act Research Support: This application investigates whether increases in low-level HIV-1 residual viremia (HIV-1 RNA) set point in patients receiving antiretroviral therapy can serve as an early indicator of impending virologic failure and whether these increases in HIV-1 resi | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| GLOBAL VACCINES INC | $414,971 | Grant | Trans-NIH Recovery Act Research Support: Although the use of highly active anti-retroviral therapy (HAART) has enhanced both the longevity and quality of life for HIV-infected individuals by controlling viral replication, financial and logistic drawbacks as well as clinical side effects and the | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF MARYLAND | $421,129 | Grant | Trans-NIH Recovery Act Research Support: This effort requires the development of new therapies that target the provirus residing within infected cells in a status of non-productive infection. Advances toward that goal will require a quantum leap in our knowledge and understanding of the biology | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $404,858 | Grant | Trans-NIH Recovery Act Research Support: Retroviruses, such as HIV-1 that causes AIDS, have an RNA genome that is reverse-transcribed into a linear viral DNA upon entering the host cell. Integration of this viral DNA into host's chromosome is an essential step in the lifecycle of retroviruse | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $480,590 | Grant | Trans-NIH Recovery Act Research Support: Effector and regulator T cells play important roles in the homeostasis of the immune system. Recent studies showed that interleukin-17 producing effectors, known as TH-17 cells, and Foxp3+ regulator T cells, despite their apparently opposite roles, are di | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON | $365,418 | Grant | Trans-NIH Recovery Act Research Support: Helicobacter pylori (Hp) infects the gastric mucosa of >50% of the world's population. Infection with this gram negative bacterium results in significant gastroduodenal diseases that include chronic gastritis, ulcers and cancer. Prevalence rates of Hp inf | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| SOUTH CAROLINA RESEARCH FOUNDATION | $156,200 | Grant | Trans-NIH Recovery Act Research Support: MOLECULAR PREDICTORS OF COLORECTAL CANCER RECURRENCE Lymph node involvement is one of the most important clinical features to determine when managing colorectal cancer patients. Node-negative disease is often cured by surgery alone, whereas node-positive | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $660,000 | Grant | Trans-NIH Recovery Act Research Support: Transcriptional silencing via promoter methylation of genes critically important for cell growth and differentiation plays a key role in myeloid leukemogenesis. Many genes are frequently methylated in acute myeloid leukemia (AML) including p15, estrogen r | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE | $413,607 | Grant | Trans-NIH Recovery Act Research Support: Pro-inflammatory cytokines and neurobehavioral symptoms in women with breast cancer. Abstract Survivors of breast cancer report debilitating behavioral symptoms, such as fatigue and neurocognitive dysfunction, which are evident in some individuals even at | Health and Human Services, Department of / National Institutes of Health | 5/18/2009 |
| HEALTH RESEARCH, INC. | $441,683 | Grant | Trans-NIH Recovery Act Research Support: The aim of this funded R21 proposal is to study the role of dietary supplement selenium (Methylselenocysteine or MSC) in supranutritional doses in retarding cancer growth and synergistically enhancing chemotherapeutic efficacy in combination setting throu | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| PURDUE UNIVERSITY | $376,147 | Grant | Trans-NIH Recovery Act Research Support: The proposed work focuses on the discovery of reliable biomarkers for the early detection of liver cancer. Patients with hepatitis are particularly susceptible to the development of hepatocellular cancer, although the disease mechanisms are poorly underst | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| OHIO STATE UNIVERSITY, THE | $671,000 | Grant | Trans-NIH Recovery Act Research Support: Strategies to overcome resistance to common chemotherapy regimens are necessary to improve upon the currently dismal prognosis of acute myeloid leukemia (AML) patients with refractory disease or who have relapsed following initial achievement of complete | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF ILLINOIS | $370,909 | Grant | Trans-NIH Recovery Act Research Support: The selective estrogen receptor modulator tamoxifen is efficacious in the treatment and prevention of breast cancer, the most common cancer in women. However, tamoxifen treatment causes menopausal symptoms including hot flashes. In addition, tamoxifen c | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $362,529 | Grant | Trans-NIH Recovery Act Research Support: Reactivation of Tumor Suppressor Genes in Breast Cancer by Dietary Supplements Hypermethylation-silenced tumor suppressor gene (TSG) is a hallmark of most cancers, including breast cancer and has been detected in pre-invasive lesions and/or high-risk tiss | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC. | $712,163 | Grant | Trans-NIH Recovery Act Research Support: This project will validate a novel technology that has been developed to predict which patients with esophageal or rectal cancer will respond to treatment with radiation and chemotherapy. The relevance of this technology is significant as it may enhance t | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF WASHINGTON | $303,019 | Grant | Trans-NIH Recovery Act Research Support: The primary goal of this application is to enhance a successful intervention that was developed to disseminate evidence-based cancer prevention strategies to workplaces. Cancer and other chronic diseases are the leading causes of mortality and morbidity a | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $372,680 | Grant | Trans-NIH Recovery Act Research Support: Several randomized controlled trials have demonstrated that exercise can benefit cancer patients in terms of their physical functioning and symptoms. Few studies have included patients with advanced disease, a group that is living longer with their diseas | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $338,800 | Grant | Trans-NIH Recovery Act Research Support: How does exercise counteract stress-induced tumor growth? Increased physical activity following the diagnosis of cancer has been demonstrated to significantly reduce cancer recurrence. Furthermore, exercise has been demonstrated to have antidepressant eff | Health and Human Services, Department of / National Institutes of Health | 5/13/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $396,880 | Grant | Trans-NIH Recovery Act Research Support: Title: 'Manipulation of Kinase Activity by KSHV LANA' Kaposi's sarcoma associated herpesvirus (KSHV) is a herpesvirus that is associated with the blood vessel lesion Kaposi's sarcoma and the B cell malignancies primary effusion lymphoma and mult | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| GEORGETOWN UNIVERSITY (THE) | $378,846 | Grant | Trans-NIH Recovery Act Research Support: There are an estimated 2.2 million breast cancer survivors alive today in the US including a significant number of Asian survivors. Breast cancer is the most common cancer in Chinese women, the largest Asian population, of which 70% are immigrants. Chines | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | $345,277 | Grant | Trans-NIH Recovery Act Research Support: Major activity this quarter has been directed toward development of algorithms in SAS that will permit calculation of network characteristics with interaction with other network analytic programs (such as Pajek, Ucinet). These programs, now almost finish | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $325,000 | Grant | Trans-NIH Recovery Act Research Support: The major objective of the proposed research is to study the interaction of the brain reward system with the brain pain system and the effects of morphine on this interaction. The intracerebral implanting of two stimulating electrodes, one in a reward sit | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| WOMEN & INFANTS HOSPITAL OF RHODE ISLAND | $402,731 | Grant | Trans-NIH Recovery Act Research Support: The primary goals of this project are to develop, refine, and pilot test an integrative smoking relapse prevention intervention for postpartum women. Rates of postpartum smoking relapse are high (70-90%) among women who quit smoking in anticipation of or | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| MCLEAN HOSPITAL CORPORATION, THE | $380,790 | Grant | Trans-NIH Recovery Act Research Support: This R21 application responds to PA-07-227, which describes an urgent need for a greater understanding of the underlying neurobiological and behavioral mechanisms in the addictive effects of methamphetamine (MA) and cocaine. The use and abuse of MA and co | Health and Human Services, Department of / National Institutes of Health | 6/19/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO | $396,432 | Grant | Trans-NIH Recovery Act Research Support: Agonists acting at the 5 opioid receptor (MOR) (e.g. morphine and its analogs) are the mainstay of pain management; however there are serious adverse effects (e.g. dependence) and social and legal issues which limit their use. Consequently there has been | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| THE CHILDRENS HOSPITAL LOS ANGELES | $439,400 | Grant | Trans-NIH Recovery Act Research Support: Drug overdose is the single greatest cause of mortality among injection drug users (IDUs) in the U.S. Fatal heroin overdoses cause more than half of all deaths among IDUs, which far exceeds the proportion of deaths due to AIDS or other causes. Administrat | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $424,875 | Grant | Trans-NIH Recovery Act Research Support: Suicide, with its related mortality and morbidity, represents a significant and preventable loss of human life. Existing research indicates that problematic alcohol and drug use are closely linked to both fatal and non-fatal suicide attempts. Given the st | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, THE | $456,500 | Grant | Trans-NIH Recovery Act Research Support: During this two year award, we proposed to examine the role of decoy receptor expression in the ability to respond to corticosteroids during periods of acute hearing decline in patients with autoimmune inner ear disease (AIED). AIED is difficult to treat | Health and Human Services, Department of / National Institutes of Health | 4/30/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $254,242 | Grant | Trans-NIH Recovery Act Research Support: Motion sickness is a debilitating condition that affects a wide range of individuals in both daily life and in pathological conditions. While it is widely seen in many clinical settings, it remains difficult to objectively evaluate and treat. Recent work | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| FORSYTH DENTAL INFIRMARY FOR CHILDREN | $531,362 | Grant | Trans-NIH Recovery Act Research Support: This is a translational medical research effort whose long-term goal is to develop a photochemotherapeutic system for prevention, control and/or treatment of periodontitis based on recent advances in photomedicine and nanotechnology. Biofilms that coloniz | Health and Human Services, Department of / National Institutes of Health | 4/27/2009 |
| UNIVERSITY OF FLORIDA | $384,043 | Grant | Trans-NIH Recovery Act Research Support: The ability of the bacterium Streptococcus mutans to take up DNA from its local environment is known as genetic competence, and it is an important component of the virulence of this organism. Existing data indicates that in the natural biofilm environmen | Health and Human Services, Department of / National Institutes of Health | 4/29/2009 |
| VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY | $419,229 | Grant | Trans-NIH Recovery Act Research Support: This R21 proposal describes the development of three-dimensional (3-D) in vitro liver sinusoids comprised of primary hepatocytes and primary liver sinusoidal endothelial cells. These in vitro constructs will be used in detoxification studies. The specific | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| HEALTHPARTNERS RESEARCH FOUNDATION | $412,469 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Linking home environments and primary care: Obesity prevention for 2-4 year olds. Obesity prevention for at-risk preschool children is a public health priority. The pediatric primary care setting is a relatively untapp | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $383,125 | Grant | Trans-NIH Recovery Act Research Support: The growing obesity epidemic in the US has heightened the importance of its primary prevention across all ages; however, prevention efforts generally focus upon community-based intervention studies in pediatric settings or clinical intervention studies am | Health and Human Services, Department of / National Institutes of Health | 7/19/2009 |
| UNIVERSITY OF UTAH, THE | $413,875 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The incidence and prevalence of end-stage renal disease is increasing at an alarming rate, new innovative therapies for halting the progress of chronic renal failure are urgently demanded. Overexpression of transformin | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $2,685,074 | Grant | Trans-NIH Recovery Act Research Support: Innovative therapies to eliminate persistent HIV infection ARRA Project 1: Novel Therapeutics to Target HIV Latency -Evaluate novel HIV inducer activity in vitro and in vivo -Perform molecular profiling studies of novel inducers of HIV expression biomark | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $14,871,333 | Grant | Trans-NIH Recovery Act Research Support: Nine institutions of different sizes, geographical location, and culture have come together to build and implement a Federated National Informatics Network that will allow any investigator across America to discover research resources that are presently i | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | $854,874 | Grant | Trans-NIH Recovery Act Research Support: The overall goals of this project are to investigate the role(s) of the NG2 proteoglycan in mammary tumor vascularization and progression. For this purpose we will utilize the MMTV-PyMT transgenic mouse model of breast cancer. Preliminary experiments have | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | $830,082 | Grant | Trans-NIH Recovery Act Research Support: This grant will extend our studies on the role of ATF2, a transcription factor and DNA damage response protein, in melanoma development and progression. Our preliminary results point to the function of ATF2 as an oncogene in malignant melanoma. We will ex | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| BUTLER HOSPITAL | $1,319,459 | Grant | Trans-NIH Recovery Act Research Support: We believe that how one reacts to the discomfort of nicotine withdrawal and quitting smoking is a promising avenue of investigation and may have important treatment implications. We have proposed that the inability to tolerate the distress of nicotine wi | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| CORNELL UNIVERSITY, INC | $129,044 | Grant | Trans-NIH Recovery Act Research Support: The irreversible commitment to M phase requires the explosive activation of the key mitotic driver, CDK1/Cyclin B (also known as M phase promoting factor, or MPF). Since the molecular identification of MPF in the 1980s, many investigators have been attra | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $243,846 | Grant | Trans-NIH Recovery Act Research Support: These supplemental funds will be used to obtain additonal personnel and equipment and to replace antiquated pieces of equipment essential to this project. One of the original aims of the parent grant has broadened in scope. Because we have made great prog | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | $196,382 | Grant | Trans-NIH Recovery Act Research Support: The proposed research aims to study regulation of macromolecular transport through plant intercellular connections, the plasmodesmata (PD). PD interconnect most cells within a mature plant and are critical for maintaining and regulating communication with | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | $67,241 | Grant | Trans-NIH Recovery Act Research Support: Meiosis is a specialized cell division used by sexually reproducing organisms to produce haploid gametes from diploid cells. This reduction in chromosome number is accomplished by having two rounds of chromosome segregation follow a single round of chromo | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF ROCHESTER | $118,631 | Grant | Trans-NIH Recovery Act Research Support: The supplement covers the cost for replacement of 25-30 year old equipment that is critical to the success of the project. We will purchase a new super-speed centrifuge (about $68K) and a new ultracentrifuge (about $50K). | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| BRANDEIS UNIVERSITY | $278,466 | Grant | Trans-NIH Recovery Act Research Support: This proposal is a Recovery Act Competitive Revision as specified in notice number NOT-OD- 09-058, NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications. The parent grant is R01 GM054403, IMP Dehydrogenase. IMP dehydro | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $128,779 | Grant | Trans-NIH Recovery Act Research Support: TITLE: Mechanisms of Tissue Morphogenesis in C. elegans DESCRIPTION/PURPOSE: This supplemental project will develop and implement new software for automatic cell identificaiton and tracking in C. elegans embryos. Work from the parent project has ca | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | $155,334 | Grant | Trans-NIH Recovery Act Research Support: The long term goal of this research is to understand the role of histone modifications such as acetylation and methylation and their effect on chromosome function, using the widely-studied yeast, Saccharomyces cerevisiae, to study these processes. In part | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $197,673 | Grant | Trans-NIH Recovery Act Research Support: The broad, long-term objective of the proposed project is to elucidate the catalytic mechanism of Mot1, a prototypical member of the Snf2/Swi2 ATPase family. Mot1 is an essential, conserved transcription factor that uses ATP hydrolysis to dissociate TATA | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $270,051 | Grant | Trans-NIH Recovery Act Research Support: Determination of a high resolution structure of the InsP3R C tail in complex with Bcl xL will provide a basis for understanding how binding of Bcl xL affects channel Ca2+ signaling functions, with relevance for cell death mechanisms in cancer and neurodeg | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CHICAGO, THE | $429,000 | Grant | Trans-NIH Recovery Act Research Support: Although the effort to catalog the full range of epigenetic marks and assign them functional roles has been a remarkable success to date, how epigenetic states persist through replication and mitosis (epigenetic inheritance) remain as important open quest | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $408,375 | Grant | Trans-NIH Recovery Act Research Support: The long-term objective of this study is to understand the molecular mechanism of prostate formation and maintenance. The prostate has been the subject of intense biomedical research not only because of its key role in sexual function, but more because of | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TEXAS ENGINEERING EXPERIMENT STATION | $385,753 | Grant | Trans-NIH Recovery Act Research Support: Diabetes is an international health concern with millions of patients worldwide. There is an unmet need to develop a biosensor technology that is a fast and convenient way to monitor blood glucose in diabetics. Thus, the particular goal of this research i | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| ST LUKE'S-ROOSEVELT HOSPITAL CENTER | $445,585 | Grant | Trans-NIH Recovery Act Research Support: Osteoporosis is one of the leading health problems in the United States. Recent studies suggest that adipocytes in bone marrow and osteoblasts share the same precursor, mesenchymal stem cells (MSC). Human imaging studies [i.e., magnetic resonance spectros | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $630,450 | Grant | Trans-NIH Recovery Act Research Support: The purpose of the proposed animal studies is to define the mechanistic basis for the interaction between the common genetic variant, C677T, and the availability of folate and other related B-vitamins in determining the risk of colon cancer. Unraveling t | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC. | $422,338 | Grant | Trans-NIH Recovery Act Research Support: Retinitis pigmentosa is a hereditary retinal degeneration that leads to loss of night vision, side vision, and eventually most of central vision. Cystoid macular edema (CME), a complication involving swelling of the central retina and reduction in visual | Health and Human Services, Department of / National Institutes of Health | 6/30/2009 |
| UNIVERSITY OF DELAWARE | $219,960 | Grant | Trans-NIH Recovery Act Research Support: ROBOT-ASSISTED MOBILITY FOR INFANTS WITH SEVERE SPINA SPINA This study will be the first to quantify the effect of intensive power wheelchair training on special needs infants with any diagnosis. Specifically, we will quantify the effect of training on t | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| UNIVERSITY OF MARYLAND | $425,314 | Grant | Trans-NIH Recovery Act Research Support: Cesarean section (CS) is currently used at over twice the rate recommended by the World Health Organization (CDC, 2006); use of the procedure has almost doubled in the last two decades for reasons that are as yet poorly understood. Overutilization results | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $409,754 | Grant | Trans-NIH Recovery Act Research Support: Offspring receive differential early somatosensory stimulation through parenting and other processes, such as neonatal exposure to novelty. This early somatosensory stimulation is known to have long-term effects on the development of stress reactivity and | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $423,500 | Grant | Trans-NIH Recovery Act Research Support: Sexually transmitted infections (STI), including human immunodeficiency virus (HIV), pose significant health risks. Consistent and correct use of condoms can be a highly effective method of preventing the transmission of HIV and many STIs, yet studies sho | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| WAKE FOREST UNIVERSITY | $407,000 | Grant | Trans-NIH Recovery Act Research Support: Children with complex chronic conditions (CCC) receive care from diverse medical, educational and social service providers through various agencies for a prolonged period of time. Coordination of care between agencies serving these children is lacking, re | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | $999,998 | Grant | Trans-NIH Recovery Act Research Support: RNA cleavage is a fundamental and ancient host response for controlling viral infections in both plants and animals. In higher vertebrates, including humans, RNA cleavage as a means of controlling viruses is mediated by the type I interferons (IFN) throug | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF NEW MEXICO | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: This challenge project is based on (a) our pioneering work on IRGM as an autophagy factor 1, and (b) the genetic linkage recognition 2 of the role of autophagy and IRGM in Crohn's disease. The main objective is two-fold: (I) to delineate the role of autop | Health and Human Services, Department of / National Institutes of Health | 9/26/2009 |
| UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (15) Translational Science and specific Challenge Topic, 15-AI-102 Develop diagnostics and drugs for multiple or extensively drug-resistant tuberculosis (MDR/XDR TB). We will develop a rapid and high-through | Health and Human Services, Department of / National Institutes of Health | 9/26/2009 |
| UNIVERSITY OF UTAH, THE | $993,532 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Improved interfaces for prostheses to improve rehabilitation Attaching exo-prostheses directly to bone-anchored, osseointegrated implants that pass percutaneously through the skin is being considered as an alternative | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| CHILDRENS HOSPITAL OF PHILADELPHIA | $998,516 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (08) Genomics and specific Challenge Topic, 08-AR-101: Genotyping of Existing Cohorts in Rheumatic, Skin, and Musculoskeletal Diseases. These studies will utilize existing clinical cohorts to create a broadl | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL | $729,808 | Grant | Trans-NIH Recovery Act Research Support: In response to the need for treatments appropriate for adolescent smokers in rural Appalachia, this research (utilizing a two-group randomized-control design, n=35 per group) will evaluate the effectiveness and efficacy of a new and innovative Web-based c | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $2,957,107 | Grant | Trans-NIH Recovery Act Research Support: Tobacco usage remains one of the most prevalent forms of substance abuse and exerts a tremendous cost on the world health and economy. While it is known that nicotine is the major component in tobacco smoke responsible for addiction, we currently have onl | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF TENNESSEE | $2,321,862 | Grant | Trans-NIH Recovery Act Research Support: Accidental or purposeful exposure of people to high levels of radiation poses a serious immediate risk and potential long-term health risk. NO FDA approved radiomitigant effective 24-48h after radiation injury is available today. Thus, there is a critical | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $1,981,634 | Grant | Trans-NIH Recovery Act Research Support: Chronic pain is a major public health problem that is only growing worse as the gaps in our knowledge base continue and the population at risk grows. We believe we have a cost effective solution that could become a model for other pain management facilit | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $1,077,231 | Grant | Trans-NIH Recovery Act Research Support: This project addresses the design of cellular and animal screening procedures that can be used to assess the potential danger of engineered nanomaterials that are currently being introduced into the marketplace. We will develop a predictive toxicological | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| MICHIGAN TECHNOLOGICAL UNIVERSITY | $800,721 | Grant | Trans-NIH Recovery Act Research Support: One potential result of climate change in the United States is increased frequency and intensity of wildland fires. These wildfire fires have the potential to destroy large amounts of public and private property, as was seen during the summer of 2003 and | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $564,741 | Grant | Trans-NIH Recovery Act Research Support: Autism spectrum disorders (ASD) are marked by significant impairments in social functioning and social cognition; although these symptoms are core features of ASD-and perhaps the most debilitating-there has been little headway in the development of pharma | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $568,750 | Grant | Trans-NIH Recovery Act Research Support: This project is in response to the Recovery Act Limited Competition: Research to Address the Heterogeneity in Autism Spectrum Disorders (RFA-MH-09-172). The proposed project will determine the applicability, reliability, and validity of the newly revised | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $549,500 | Grant | Trans-NIH Recovery Act Research Support: Autism spectrum disorders (ASDs) are common, debilitating disorders affecting social interaction, communication, and repetitive behaviors. Recent genetic findings have identified mutations in synaptic cell adhesion genes and genes encoding their interacti | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $391,427 | Grant | Trans-NIH Recovery Act Research Support: Asthma has long been recognized as having a significant psychosocial component. Considerable evidence exists that psychosocial factors, such as anxiety, depression, and inhibited temperament, are associated with asthma. While many studies have contrasted | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| SAINT VINCENTS CATHOLIC MEDICAL CENTERS OF NEW YORK | $238,350 | Grant | Trans-NIH Recovery Act Research Support: This award is issued under The American Recovery and Reinvestment Act of 2009. The National Institute of Health awarded a grant in the amount of $238,350 to Saint Vincent Catholic Medical Centers of New York in support of the Prediction of Response to Rev | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $422,550 | Grant | Trans-NIH Recovery Act Research Support: In patients with chronic obstructive pulmonary disease (COPD), which is characterized by bacterial colonization of the airways, co-infection with respiratory viruses further impairs host defenses, leading to bacterial overgrowth and infection, as well as | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE | $434,200 | Grant | Trans-NIH Recovery Act Research Support: Acting on multiple tissue types, adiponectin (Adipo) exerts insulin-sensitizing and cardiovascular protective effects. The physiological and/or clinical implications are that the plasma level of Adipo is negatively related to adiposity, insulin resistance | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $740,000 | Grant | Trans-NIH Recovery Act Research Support: GST alleles and oxidant pollutants in the pathogenesis of asthma - ARRA Description: Glutathion S-transferases (GSTs) are a superfamily of enzymes responsible for both the detoxification of a spectrum of xenobiotics and the response of cells to oxidative | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $398,417 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is the prototype development and evaluation of a wireless laboratory animal monitoring system (WLAMS) for the improvement of animal welfare and the direct and real-time monitoring of disease status. The system will consist of thre | Health and Human Services, Department of / National Institutes of Health | 8/07/2009 |
| NORTHWESTERN UNIVERSITY | $432,740 | Grant | Trans-NIH Recovery Act Research Support: Multiple pathway models of attention deficit hyperactivity disorder (ADHD) Project Summary/Abstract The goal of this grant is to examine brain differences during executive functioning and reward processing among children with attention deficit hyperactivi | Health and Human Services, Department of / National Institutes of Health | 6/17/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO | $371,042 | Grant | Trans-NIH Recovery Act Research Support: Brain-derived neurotrophic factor (BDNF) plays a fundamental role in determining the plasticity and functional architecture of neurons in the adult brain. A frequent, non-conservative polymorphism in the human BDNF gene has been recently identified, which | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | $422,266 | Grant | Trans-NIH Recovery Act Research Support: Epigenetic regulation of microRNAs in neurogenesis Histone deacetylase (HDAC) inhibitors such as valproate (VPA) are commonly used to treat epilepsy. One me- chanism of their efficacy may result from epigenetic effects on differentiation of neural precurs | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| KAISER FOUNDATION HOSPITALS | $441,521 | Grant | Trans-NIH Recovery Act Research Support: Efforts to improve adherence to highly active antiretroviral therapy (HAART) regimens are critical for improving clinical outcomes in HIV-infected patients and reducing costly utilization of hospitalizations, emergency department and urgent care visits. | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $400,615 | Grant | Trans-NIH Recovery Act Research Support: This project is being supported with funds from the American Recovery and Reinvestment Act, which may involve a reduction in the research aims and scope. If necessary, a revised abstract will be posted soon and this notice removed. DESCRIPTION (provided | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| UNIVERSITY OF ILLINOIS | $436,121 | Grant | Trans-NIH Recovery Act Research Support: The overall study objective is to develop a culturally targeted patient navigation training curriculum aimed at increasing breast, cervical and colorectal cancer screening behaviors in lesbian, gay, bisexual and transgendered (LGBT) persons. We propose a | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| EMORY UNIVERSITY | $426,250 | Grant | Trans-NIH Recovery Act Research Support: Improving Self Management and Outcomes in Heart Failure Patients with Diabetes Abstract This proposal addresses the problems of poor patient outcomes and high readmission rates in patients with concomitant heart failure (HF) and diabetes mellitus (DM). T | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC. | $412,500 | Grant | Trans-NIH Recovery Act Research Support: Parkinson's disease (PD) is a progressive disease that usually affects the motor system, but it is also associated with a non-motor symptom complex that contributes significantly to morbidity and institutionalization, more than quadrupling the cost of car | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION | $402,854 | Grant | Trans-NIH Recovery Act Research Support: The principal purpose of this project is to discover the biological changes that take place as a result of learning. We plan to characterize the changes that take place in identified neurons in the deep cerebellar nuclei as a function of classical condit | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $405,512 | Grant | Trans-NIH Recovery Act Research Support: The funding obtained under the ARRA is for conducting research within the broad area of Alzheimer?s disease (AD) pathogenesis. Although several AD-linked genetic mutations have been identified that directly cause the disease (due to an accumulation of amy | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| MCLEAN HOSPITAL CORPORATION, THE | $434,500 | Grant | Trans-NIH Recovery Act Research Support: GABAergic interneurons, born in remote germinative zones in the ventral forebrain (telencephalon) migrate tangentially into the cortex to adopt their specific positions. The cell types and molecular cues that regulate this migration remain to be elucidate | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $467,500 | Grant | Trans-NIH Recovery Act Research Support: A central question in neurodegenerative diseases is how specific populations of neurons undergo cell death. Selective degeneration of motor neurons occurs in the setting of diverse insults including RNA viruses such as HIV and West Nile, and in heritable | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $437,063 | Grant | Trans-NIH Recovery Act Research Support: An arteriovenous malformation (AVM) is a vascular malformation in the brain with direct connections between arteries and veins such that blood bypasses brain tissue. A patient with an AVM may not be aware of it until the AVM causes hemorrhage into the bra | Health and Human Services, Department of / National Institutes of Health | 6/15/2009 |
| CORNELL UNIVERSITY, INC | $392,862 | Grant | Trans-NIH Recovery Act Research Support: Clinical evidence suggests a strong link between Alzheimer's disease (AD) and cerebral microvascular dysfunction, but it remains unclear whether they contribute independently to dementia, or if AD pathology triggers microvascular disease, or vice versa. I | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| WAYNE STATE UNIVERSITY (INC) | $402,400 | Grant | Trans-NIH Recovery Act Research Support: The rat respiratory system is an excellent model for experimental design in addressing respiratory-related issues that arise from injury. The C2 hemisection is a reliable and simple model employed in SCI research on the respiratory system. In this model, | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO | $408,219 | Grant | Trans-NIH Recovery Act Research Support: This study is part of an ongoing collaborative effort between researchers at the University of Texas Health Science Center at San Antonio (UTHSCSA), Research Imaging Center (RIC), and the Southwest National Primate Research Center (SNPRC) at the Southwest | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| DUKE UNIVERSITY | $420,600 | Grant | Trans-NIH Recovery Act Research Support: The goal of this research is to elucidate the physiological and molecular responses that occur in response to persistent mitochondrial DNA (mtDNA) damage. Mitochondrial DNA integrity is critical for human health, and mtDNA is more sensitive than nuclear D | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| UNIVERSITY OF KENTUCKY | $408,375 | Grant | Trans-NIH Recovery Act Research Support: Traumatic brain injury (TBI) is a global health problem that is financially crippling for many families because of both specialized care and lost financial income. TBI involves at least two separate injury cascades that lead to neuronal and cognitive dysf | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| HENRY FORD HEALTH SYSTEM | $324,865 | Grant | Trans-NIH Recovery Act Research Support: Glioma is the most frequent primary intracranial neoplasm in adults and are invariably fatal. Malignant gliomas account for approximately one-third of all primary brain tumors in adults or 18400 new cases in the United States annually. Despite advances in | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| DUKE UNIVERSITY | $429,000 | Grant | Trans-NIH Recovery Act Research Support: Chronic pathological pain and certain epileptic syndromes are neuropsychiatric disorders that share an increased female prevalence and refractoriness to treatment. The latter feature is considered to be linked to pathologically increased neuronal excitabi | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| UNIVERSITY OF NEW MEXICO | $422,000 | Grant | Trans-NIH Recovery Act Research Support: Stroke is the major neurological illness and recombinant tissue type plasminogen activator (rtPA) is the only approved treatment. Use of rtPA is limited to three hours after stroke because of the risk of intracerebral hemorrhage. Toxicity of rtPA occurs w | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $422,500 | Grant | Trans-NIH Recovery Act Research Support: Multiple Sclerosis (MS) is the prototypical CNS demyelinating disease, and though remyelination often occurs in the early stages of the disease, it eventually fails in later stages, contributing to progressive functional decline. All approved medical ther | Health and Human Services, Department of / National Institutes of Health | 9/20/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $418,908 | Grant | Trans-NIH Recovery Act Research Support: Title: High Content Screens of Neuronal Development for Autism Research. Disrupted neural development is thought to underlie autism and related disorders such as Rett syndrome, but the mechanisms are unknown and possibly highly diverse. This pilot proje | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| WASHINGTON STATE UNIVERSITY | $558,294 | Grant | Trans-NIH Recovery Act Research Support: Conventional 2D-PAGE is cumbersome, slow and difficult to automate. Although, multidimensional, high performance capillary chromatography, electrophoresis and electrochromatography are robust and fully automatable, they are bottlenecked by their inherentl | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $949,006 | Grant | Trans-NIH Recovery Act Research Support: Characteristics of the built environment can create/sustain health disparities, hence tackling them requires interventions to address macro-level factors that influence health. By addressing the causes of health disparites among Latino children/youth earl | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| BROWN UNIVERSITY IN PROVIDENCE IN STATE OF RI AND PROVIDENCE PLANTATIONS | $968,252 | Grant | Trans-NIH Recovery Act Research Support: Effective drugs, such as aspirin, beta-blockers, statins, and ace-inhibitors, are a cornerstone in the prevention and treatment of heart disease, yet over half of appropriate patients do not receive them. The cost of chronic drug therapy is a substantial | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: This application addresses Challenge Area 06, Enabling technologies; Specific challenge topic 06-MH-103, 'New technologies for neuroscience research' MicroRNAs are believed to contribute to schizophrenia, autism, Tourette's syndrome, mood disorders, and f | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF IOWA, THE | $967,907 | Grant | Trans-NIH Recovery Act Research Support: This application addresses the broad Challenge Area (05) Comparative Effectiveness Research and the specific Challenge Topic: 05-NS-104* Intervention vs. Best Medical Therapy in Asymptomatic Persons With Identified Vascular Abnormalities. The Internationa | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $1,332,400 | Grant | Trans-NIH Recovery Act Research Support: The Go grant award funded a 2-year research project investigating a new modality of therapy directed at memory impairment in the elderly. Aging is often associated with cognitive deficits, especially decline in memory functions that depend on the structur | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $1,933,050 | Grant | Trans-NIH Recovery Act Research Support: Facioscapulohumeral muscular dystrophy (FSHD) is a genetically dominant progressive myopathy affecting approximately 25,000 individuals in the United States. It is the third most common muscular dystrophy by incidence with a prevalence near or surpassin | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| BROWN UNIVERSITY IN PROVIDENCE IN STATE OF RI AND PROVIDENCE PLANTATIONS | $939,768 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (05) Comparative Effectiveness Research and specific Challenge Topics, 05-AA-101: Innovative Analysis of Existing Clinical Datasets and 05-AA-102: Adaptive Designs and Person-Centered Data Analysis for Alcoh | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $833,029 | Grant | Trans-NIH Recovery Act Research Support: Recent studies indicate that neuroimmune factors are important signaling molecules in the brain and contribute to both normal brain function and cognitive dysfunction associated with a variety of disorders including alcoholism. Our knowledge about the rol | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| SINAI HEALTH SYSTEM | $998,575 | Grant | Trans-NIH Recovery Act Research Support: The North Lawndale Diabetes Community Action Project addresses Challenge Area Comparative Effectiveness Research and the specific Challenge Topic 05-MD-102 Prevention of Chronic Diseases in Disparity Populations. The Sinai Urban Health Institute, Sinai He | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| THE VANDERBILT UNIVERSITY | $672,712 | Grant | Trans-NIH Recovery Act Research Support: Using new technologies to improve or measure adherence. The primary aim of this research is to develop and test a method for increasing adherence to treatment recommendations for mothers of children with emotional or behavior problems. Parental psychopath | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| EMORY UNIVERSITY | $782,143 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (15) Translational Science, 15-MH-109: Prefrontal cortex regulation of higher brain function and complex behaviors, which is directed to examine mechanisms by which the developing and mature prefrontal corte | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $983,077 | Grant | Trans-NIH Recovery Act Research Support: This application is in response to Grand Opportunity (GO) RFA-OD-09-004 for Exploratory Research in the Development of Vaccines for AIDS-associated Malignancies. We will focus explore using the Epstein-Barr virus as a persistent vaccine vector for inducin | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $3,527,236 | Grant | Trans-NIH Recovery Act Research Support: Conducting timely, high quality, comparative effectiveness research (CER) and creating and delivering recommendations for genomic tests in cancer care and prevention are major technical and intellectual challenges. Yet with the increased use of Electronic | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF NEW MEXICO | $269,966 | Grant | Trans-NIH Recovery Act Research Support: Improvement in health for populations around the globe has become a leading international priority. As the world becomes progressively more interconnected, it is apparent that major global health burdens facing our international community will require an | Health and Human Services, Department of / National Institutes of Health | 5/06/2009 |
| UNIVERSITY OF CALIFORNIA, SANTA BARBARA | $739,435 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Literature and clinical research suggest that improvements in communicative initiations are associated with widespread improvements in communication and in related core symptoms of autism (communicative, social, and be | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |