Listing all stimulus spending by amount, in descending order. Return to National Institutes of Health page
Amount refers to both the amount of stimulus funding going toward the project and the face value of the loan.
| Recipient | Amount | Type | Description | Federal Dept./Agency | Date |
|---|---|---|---|---|---|
| UNIVERSITY OF CHICAGO, THE | $50,000 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this supplement is to strengthen two core facilities by adding two key pieces of equipment that will improve our capability to support translational research in the area of Cancer Immunology. The Human Immunologic Monitoring (HIM) facility | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| NEW YORK UNIVERSITY (INC) | $93,456 | Grant | Trans-NIH Recovery Act Research Support: The NYU Cancer Institute is committed to increasing the number of minority researchers working in cancer related areas. In section 10.7 of our P30 application we identify current programs which focus on efforts to increase the number of researchers repres | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $3,301,314 | Grant | Trans-NIH Recovery Act Research Support: HDAC CLASS IIA SPECIFIC PET RADIOTRACERS FOR PET IMAGING OF CNS | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| CALIFORNIA INSTITUTE OF TECHNOLOGY | $1,608,391 | Grant | Trans-NIH Recovery Act Research Support: This project will generate and validate fourteen strains of mice with fully functional fluorescent mouse nicotinic receptor (nAChR) subunits. These strains will be constructed using the proven and reasonably efficient method of exon replacement via homol | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $8,950,690 | Grant | Trans-NIH Recovery Act Research Support: This application is submitted by a group of investigators at 9 sites distributed throughout the U.S. where there are active developmental research programs involving substantial numbers of typically developing children, and neuroimaging investigators with | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF ARIZONA | $180,054 | Grant | Trans-NIH Recovery Act Research Support: Point defects in the molybdenum-containing enzyme, sulfite oxidase (SO), can produce sever nenatal neurological symptoms that include dislocated ocular lenses, mental retardation, attenuated growth of the brand and early death. This research will use sit | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY | $36,724 | Grant | Trans-NIH Recovery Act Research Support: Our laboratory seeks to understand the control of messenger RNA decay in the gram-positive bacterium, Bacillus subtilis. While much is known about the mechanism and regulation of mRNA synthesis (transcription) and translation of mRNA into protein, little | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $162,803 | Grant | Trans-NIH Recovery Act Research Support: R01 funding has helped define the forces that drive transport and effect of endogenous signals and exogenously delivered compounds. The timing of this work could not be more critical. Drug-eluting stents (DES) present an innovative technology with great p | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| NORTHWESTERN UNIVERSITY | $163,485 | Grant | Trans-NIH Recovery Act Research Support: Nitric oxide synthase (NOS) is a family of enzymes that produces nitric oxide for use in regulating blood pressure, in immune system functioning, and in brain development, memory, and learning. Under pathological conditions, excess nitric oxide is produce | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| THE VANDERBILT UNIVERSITY | $182,321 | Grant | Trans-NIH Recovery Act Research Support: The broad research objective of the parent grant is to better understand tyrosine kinase signaling pathways activated in response to integrin-mediated cell-ECM adhesion, both in terms of biochemical mechanism and cell biological impact. The supplement wil | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF WASHINGTON | $187,302 | Grant | Trans-NIH Recovery Act Research Support: The coupled transfer of electrons and protons transfer is fundamental in many areas of biology. It is central to bioenergetics and the use of redox reactions to generate proton gradients. It is key to the catalytic cycles of many metalloenzymes and meta | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $77,250 | Grant | Trans-NIH Recovery Act Research Support: Our research focuses on innate immunity in a model organism, the fruit fly Drosophila. By analyzing immune defenses across species representing diverse habitats, we hope to build a predictive model for innate immune gene expression. Such a model would all | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF CONNECTICUT | $106,708 | Grant | Trans-NIH Recovery Act Research Support: Defects in ciliary motility are now known to lead to a broad array of human genetic disorders. Dyneins are molecular motors required for the motile behavior of cilia and flagella. To understand how these organelles generate force, we need to determine the | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $124,812 | Grant | Trans-NIH Recovery Act Research Support: Centrosomes are the organelles at mitotic spindle poles that organize microtubules essential for chromosome segregation. Assembly of nascent centrosomes is a tightly regulated process that occurs exactly once each cell cycle. Defects in this process can l | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $334,706 | Grant | Trans-NIH Recovery Act Research Support: Our goal for this supplement during the two years of ARRA support is to achieve two research objectives closely related to and within the scope of the parent grant entitled, Shwachman-Diamond Syndrome: Molecular Pathogenesis. Shwachman-Diamond syndrome | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $37,407 | Grant | Trans-NIH Recovery Act Research Support: Transplantation-associated arteriosclerosis (TAA) is the major cause of death in recipients who survive more than one year after cardiac transplantation. TAA is characterized by infiltration of inflammatory cells followed by the formation of a diffuse, co | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $256,096 | Grant | Trans-NIH Recovery Act Research Support: Self-renewal is the process by which at least one daughter cell retains the full developmental potential of its predecessor when stem cell division takes place. It is critically important for maintaining lifelong function of the blood forming (hematopoiet | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| DUKE UNIVERSITY | $294,009 | Grant | Trans-NIH Recovery Act Research Support: I am requesting an administrative supplement for an NIH-funded application (HL081395) under the auspices of the American Recovery and Reinvestment Act of 2009 (NOT-OD-056). The goals of this administrative supplement are to accelerate the pace of proposed | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| VETERANS MEDICAL RESEARCH FOUNDATION OF SAN DIEGO | $198,240 | Grant | Trans-NIH Recovery Act Research Support: Caveolae and Anesthetic Induced Cardiac Protection. The series of experiments proposed in the ARRA supplement request will determine a novel role for Cav-3 expression in delayed preconditioning. Cav-3 may serve as a novel therapeutic target for protecting | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $234,602 | Grant | Trans-NIH Recovery Act Research Support: Abdominal aortic aneurysms (AAAs) comprise the 10th leading cause of death in Caucasian males 65-74 years of age and accounted for nearly 16,000 deaths overall in the year 2000. Understanding the pathophysiology of AAAs is an important undertaking. Clinic | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF IOWA, THE | $242,928 | Grant | Trans-NIH Recovery Act Research Support: Production of reactive oxygen species (ROS) and changes in the cellular redox environment regulate various aspects of cellular function. Previous studies of oxidative stress in vascular disease have focused on ROS generating systems. Little is known, ho | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $273,056 | Grant | Trans-NIH Recovery Act Research Support: Disorders of lipid metabolism are responsible for several important established risk factors for cardiovascular disease, which continues to be the leading cause of morbidity and mortality in the United States. Despite of decades of research, many aspects | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $18,134 | Grant | Trans-NIH Recovery Act Research Support: Fibroblasts mediate the abnormal tissue repair characteristic of fibrosis, but their origin in fibrotic lung remains unclear. Many of the fibrogenic characteristics of lung fibroblasts are regulated by expression of Thy-1, an outer membrane leaflet surfac | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| BRANDEIS UNIVERSITY | $17,453 | Grant | Trans-NIH Recovery Act Research Support: Ras proteins are crucial regulators of cell proliferation, survival and differentiation. Aberrant activation of Ras proteins, either by Ras mutations or by altering genes that directly or indirectly regulate Ras, is common in both solid tumors and hematol | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| THE VANDERBILT UNIVERSITY | $53,703 | Grant | Trans-NIH Recovery Act Research Support: Autoimmune pancreatitis (AIP) is a poorly understood form of pancreatic autoimmunity. Understanding AIP had been hampered by the lack of a mouse model of disease. We identified the Tgfbr2^fspKO mouse that develops AIP. Since development of autoimmunity is | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| SEATTLE CHILDREN'S HOSPITAL | $54,000 | Grant | Trans-NIH Recovery Act Research Support: Microvascular Endothelial Cells in the Pathogenesis of Chronic Kidney Injury -- The long-term objective of the proposed research is to understand how changes in renal peritubular capillaries contribute to the pathogenesis of renal interstitial fibrosis | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| THE WASHINGTON UNIVERSITY | $52,984 | Grant | Trans-NIH Recovery Act Research Support: A fully automated cell separator wold allow us to positively isolate F4/80+ cells without manipulation in less than one hour. This technology minimizes cell death and maximizes our ability to isolate pure populations of macrophages so that we can study t | Health and Human Services, Department of / National Institutes of Health | 8/19/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $279,875 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The University of California at San Diego (UCSD) and San Diego State University (SDSU) propose to continue a successful institutional research and academic career development award (IRACDA) program for postdoctoral sch | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $368,231 | Grant | Trans-NIH Recovery Act Research Support: This application seeks to develop a postdoctoral training program emphasizing excellence in both research and minority (American Indian) undergraduate education by utilizing well-developed links between the University of MN Medical School Duluth and two m | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $50,000 | Grant | Trans-NIH Recovery Act Research Support: Clinical and Behavioral Determinants of CKD Disparities is an award to support the career development of Dr. Leigh E. Boulware at Johns Hopkins University School of Medicine. Through a structured didactic plan and the conduct of several studies to investi | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF WASHINGTON | $0 | Grant | Trans-NIH Recovery Act Research Support: Acute lung injury (ALI) is a severe complication of trauma with major short and long-term consequences. ALI is the earliest and most frequent manifestation of multiple organ failure, the leading cause of death among trauma victims surviving their injury | Health and Human Services, Department of / National Institutes of Health | 9/08/2009 |
| DENVER HEALTH AND HOSPITALS AUTHORITY | $49,006 | Grant | Trans-NIH Recovery Act Research Support: Parent award is to build the foundation for a programmatic line of research to develop and test psychosocial treatments to improve treatment adherence and clinical outcome for patients with mood disorders. The supplement will contribute substantively to | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $100,000 | Grant | Trans-NIH Recovery Act Research Support: This award will provide resources to pursue further research in understanding human autoimmune diseases and will allow mentoring of physician-scientists at various stages of their careers in this area of research. The studies conducted will dissect out h | Health and Human Services, Department of / National Institutes of Health | 9/02/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $100,000 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this research-training proposal is to understand how transcriptional feedback circuits regulate phenotype in mammalian systems. The specific goal is to understand how the transcriptional circuitry of human cytomegalovirus (CMV), a he | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF PITTSBURGH THE | $406,323 | Grant | Trans-NIH Recovery Act Research Support: The objective of the award is to develop four SPNW sensors for four cardiac markers (myoglobin, BNP, c-TnI, and CK-MB) for rapid and accurate AMI diagnosis and prognosis. In order to accomplish the objective, our specific aims include: (a) develop an eff | Health and Human Services, Department of / National Institutes of Health | 4/30/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $415,561 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Our ultimate goal is to develop a new and simple method to microencapsulate drugs and other bioactive substances, particularly biomacromolecules such as proteins and peptides, in biodegradable controlled-release polyme | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF ARIZONA | $408,999 | Grant | Trans-NIH Recovery Act Research Support: Protein-Cell Assemblies as Tissue Mimics It is proposed is to directly assemble living cells and recombinant structural proteins into tissue mimics for subsequent tissue regeneration, therapeutic screening, and other biomedical applications. Electrospinni | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| UNIVERSITY OF ARIZONA | $409,720 | Grant | Trans-NIH Recovery Act Research Support: The goal of the proposed project is to study protein fiber formation using an integrated microfluidic device, and to develop green processes for generating performance protein fibers for biomedical applications. Despite significant advances in protein syn | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $577,195 | Grant | Trans-NIH Recovery Act Research Support: The prevalence of autism spectrum disorders (ASDs) has been increasing during the last 10 years with increasing burden on society. While genetic risk factors are widely implicated in ASDs, the current increase is not likely to result from genetic factors | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| LUNA INNOVATIONS INCORPORATED | $555,726 | Grant | Trans-NIH Recovery Act Research Support: Nanotechnology, the use of nanomaterials at the molecular level, is a multidisciplinary scientific field undergoing exponential growth and has broad applications among all divisions of science. One form of nanomaterials, fullerenes, are soc | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $423,183 | Grant | Trans-NIH Recovery Act Research Support: Retinal degeneration is one of the leading causes of vision loss and blindness in the world. Some retinopathies are caused by autoimmune processes. Autoantibodies against retinal proteins are strongly associated with retinal degeneration in patients with | Health and Human Services, Department of / National Institutes of Health | 8/19/2009 |
| SAINT LOUIS UNIVERSITY | $410,722 | Grant | Trans-NIH Recovery Act Research Support: HSV-1 infects half of individuals in the United States, and causes 400,000 new painful, sight-threatening eye infections each year. Our goal is to develop a prophylactic vaccine to prevent debilitating consequences of these infections. | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $414,777 | Grant | Trans-NIH Recovery Act Research Support: This study aims to evaluate a conceptual model that examines the role motor skill competence plays in influencing physical activity patterns of children, along with potential mediating factors of perceived motor competence and physical fitness. It also ex | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $433,891 | Grant | Trans-NIH Recovery Act Research Support: The specific aims of the project included the following. This project proposes new ways to analyze B-W mortality disparities in the U.S. between 1980 and 2005 by investigating the contribution of causes of death considered amenable by (1) high-quality | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $18,685 | Grant | Trans-NIH Recovery Act Research Support: This award provided summer salary support for 2 undergraduate researchers who previously volunteered in the PIs laboratory. Both UCLA undergraduates are pre-med majors and are currently in the process of applying for admission to major medical institutio | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $241,644 | Grant | Trans-NIH Recovery Act Research Support: The long-term objectives of these proposals are to better understand the biochemical and biophysical changes that occur in the human lens with aging, and which ultimately lead to cataract. The proposed studies will focus on alpha-crystallin. In addition t | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| YALE UNIVERSITY | $668,570 | Grant | Trans-NIH Recovery Act Research Support: Aminoacyl-tRNAs provide the interface between genetic information encoded in the DNA sequence of a gene and the amino acid sequence of the corresponding protein. In this supplement three important aspects of aminoacyl-tRNA formation are addressed. (i) Usi | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| YALE UNIVERSITY | $140,443 | Grant | Trans-NIH Recovery Act Research Support: A tremendous amount of cellular metabolism is dedicated to producing ribosomes, the large ribonucleoprotein factories of protein synthesis responsible for translating mRNAs into proteins. Ribosomes are synthesized in the nucleolus following a series of en | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| YALE UNIVERSITY | $201,440 | Grant | Trans-NIH Recovery Act Research Support: The main objectives of this proposal are; (i) To determine if base selection by RB69 pol is governed by a conformational change before chemistry or by the nucleotidyl transfer step itself; (ii) To understand how the triple mutant, that we have produced, c | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| YALE UNIVERSITY | $98,712 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this project is to understand the molecular mechanism by which cells acquire the essential trace metal copper. Towards this goal, we propose an integrated approach that combines electron crystallography, scanning mutagenesis, and bio | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC. | $148,828 | Grant | Trans-NIH Recovery Act Research Support: The protein-protein docking problem is one of the focal points of activity in computational structural biology. The 3D structure of a protein-protein complex, generally, is more difficult to determine experimentally than the structure of an individual pr | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF MASSACHUSETTS | $512,696 | Grant | Trans-NIH Recovery Act Research Support: This award is part of the ENCODE consortium and aims to 1) identify novel long-range acting gene regulatory elements and 2) to link these elements to specific (distant) target genes. This grant focuses on 1% of the human genome that was selected by the E | Health and Human Services, Department of / National Institutes of Health | 9/10/2009 |
| UNIVERSITY OF TENNESSEE | $158,632 | Grant | Trans-NIH Recovery Act Research Support: Hypersensitivity pneumonitis (HP) or extrinsic allergic alveolitis is an interstitial lung disease that develops following repeated exposure to inhaled environmental antigens. The disease is characterized by alveolitis and granuloma formation that in som | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $46,200 | Grant | Trans-NIH Recovery Act Research Support: Characterizing the role of CREB in leukemogenesis and normal myelopoiesis The overall purpose of this project is to characterize the mechanism by which CREB regulates normal and abnormal myelopoiesis. Expected outcomes: CREB increases short-term engraft | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| SAN DIEGO STATE UNIVERSITY FOUNDATION | $59,785 | Grant | Trans-NIH Recovery Act Research Support: Autophagy is a process that is involved in degradation of long-lived proteins and removal of damaged organelles. Autophagy is generally thought of as a survival process that is upregulated by the cells during periods of starvations, but recent studies ha | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| THOMAS JEFFERSON UNIVERSITY | $240,643 | Grant | Trans-NIH Recovery Act Research Support: Our parent grant aims to understand the biological role and therapeutic potential of S100A1, which is released from injured cardiomycocytes, in the course of cardiac inflammation and mycardial regeneration after ischemic damage. The aim of the proposed s | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| YALE UNIVERSITY | $220,112 | Grant | Trans-NIH Recovery Act Research Support: Tourette Syndrome (TS) is a neurological disorder characterized by persistent motor and vocal tics. Tics can be brief, rapid and darting movements of the face, shoulders, and extremities or more complex and purposeful in appearance. Vocal tics can be simp | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| YALE UNIVERSITY | $234,086 | Grant | Trans-NIH Recovery Act Research Support: The contributions of anatomy and biophysical properties to the function of neurons and neural circuits are best understood with the aid of computer simulations. NEURON, a program which we have developed and provide freely for Mac OS X, MS Windows, and UNI | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| YALE UNIVERSITY | $264,800 | Grant | Trans-NIH Recovery Act Research Support: The proposal here addresses two related questions that are direct extensions of our parent grant on MCH neurons. Despite many papers on the role of MCH in energy homeostasis and emotional states, and the expression of MCH axons and receptors detected by h | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| UNIVERSITY OF TENNESSEE | $156,420 | Grant | Trans-NIH Recovery Act Research Support: The project involves the assessment of motor and executive dysfunction in three mouse models of Parkinson's disease. Upon establishing baseline performance, mice will be treated with an rAAVmediated siRNA construct to silence GD3 synthase (GD3S). The tech | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $49,103 | Grant | Trans-NIH Recovery Act Research Support: The goal of this R01 (NS41574) is to understand the mechanisms that lead to neuronal dysfunction in HD, an inherited, progressive neurological disorder characterized by abnormal dance-like movements (chorea), cognitive disturbances, and disorders of mood, | Health and Human Services, Department of / National Institutes of Health | 7/26/2009 |
| THOMAS JEFFERSON UNIVERSITY | $289,925 | Grant | Trans-NIH Recovery Act Research Support: A growing body of experimental evidence suggests that hemoglobin release from lysing erythrocytes may contribute to oxidative injury to tissue surrounding a hematoma. Prior studies have demonstrated that hemoglobin toxicity is mediated by transfer of its | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $65,849 | Grant | Trans-NIH Recovery Act Research Support: Olfactory ensheathing glia (OEG) transplantation was combined with intensive treadmill step training to optimize the maximum functional recovery in adult rats following a complete spinal cord transection (spinal rats). We conducted many more procedures on | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| SUTTER WEST BAY HOSPITALS | $143,564 | Grant | Trans-NIH Recovery Act Research Support: Our broad research aim is to elucidate the mechanisms through which the basement membrane (BM) directs epithelial architecture and function, and to identify the alterations in cell-BM communications that contribute to cancer progression. Signals resulting | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| UNIVERSITY OF MASSACHUSETTS | $221,663 | Grant | Trans-NIH Recovery Act Research Support: Programmed cell death plays an important role during animal development, and defects in this process result in a variety of human disorders including cancer and autoimmunity. Apoptosis and autophagic cell death are the two most prominent morphological fo | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF TENNESSEE | $81,400 | Grant | Trans-NIH Recovery Act Research Support: Math1, a transcription factor, is one of the critical genes for the formation of hair cells (HC) in the inner ear as shown by its loss in Math1 knockout mice. However, we recently demonstrated that genotypically Math1-null hair cells are able to be gener | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $110,808 | Grant | Trans-NIH Recovery Act Research Support: The aim of the parent grant proposal was to clone the gene responsible for a new mouse craniofacial mutation, Hollow Ear (or Hol), identified by ENU mutagenesis. The Hol mutation phenocopies the Tbx1-deficient mouse mutant, but does not map to either the | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| THE CHILDRENS HOSPITAL LOS ANGELES | $150,114 | Grant | Trans-NIH Recovery Act Research Support: What is the Problem: The United States has become largely dependent on a foreign workforce. By 2025, more than 50% of all American high school (HS) students will be the children of todayG??s American minoritiesG??of those, 75% will be Hispanic. Yet only 5 | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC. | $227,021 | Grant | Trans-NIH Recovery Act Research Support: We seek continuation of the University of Kansas (KU) IMSD program, a program whose underrepresented scholars are enrolling in graduate programs in the sciences at more than twice the national average, and that has succeeded in bringing five American Indi | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF NEBRASKA | $100,000 | Grant | Trans-NIH Recovery Act Research Support: University of Nebraska Medical Center (UNMC) will partner with the Aberdeen Area Tribal Chairmen's Health Board (AATCHB), with tribal schools in Nebraska and South Dakota, and with an urban elementary school to develop, implement and evaluate health scien | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| CALIFORNIA STATE UNIVERSITY AUXILIARY SERVICES, INC | $176,018 | Grant | Trans-NIH Recovery Act Research Support: Specific Aims and Objectives The specific aims of this administrative supplement are to improve the management and programmatic aspects of the Cal State LA RISE Program. Through these improvements we will increase the pace of research training progress. W | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF MASSACHUSETTS | $67,582 | Grant | Trans-NIH Recovery Act Research Support: This award provides additional funding for 2R37AA014372-06A1 for the purchase of equipment only and will have no impact on jobs being created or maintained. More than 2 million Americans suffer from alcohol-related liver disease and about 30,000 die from | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| APPLIED BIOTECHNOLOGY INSTITUTE, INC | $26,543 | Grant | Trans-NIH Recovery Act Research Support: Hepatitis B is a major global health problem. About 350 million chronically infected people are at high risk for cirrhosis of the liver and liver cancer, resulting in appoximately a million deaths annually. Current vaccines command a $1 billion annual mar | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $80,377 | Grant | Trans-NIH Recovery Act Research Support: The award will create a position in the Department of Microbiology, Immunology and Molecular Genetics for hiring either a postdoctoral researcher or a highly qualified Staff Research Associate to contribute to the research program on Trypanosome DNA repli | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| YALE UNIVERSITY | $110,036 | Grant | Trans-NIH Recovery Act Research Support: Evidence from different disciplines suggests that acute and chronic stress-related mechanisms play an important role in the development of and the chronic, relapsing nature of addiction. These brain stress systems, including the central and peripheral cat | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| NORTH CAROLINA STATE UNIVERSITY | $30,485 | Grant | Trans-NIH Recovery Act Research Support: Training in molecular biotechnology is essential for an expanding list of disciplines that have found modern biology-based skills of critical importance in pursuing research goals in areas ranging from biochemistry to chemical engineering to plant biology | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $78,826 | Grant | Trans-NIH Recovery Act Research Support: This proposal requests support for predoctoral training in Pharmacological Sciences at the Weill Graduate School of Medical Sciences (WGSMC). The Training Program in Pharmacological Sciences at WGSMS is inter-departmental and inter-institutional, comprisi | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| PROGENICS PHARMACEUTICALS, INC. | $580,717 | Grant | Trans-NIH Recovery Act Research Support: Award Title: HIV-1 Therapy with CCR5 mAb PRO 140 Award Description: PRO 140 is a humanized monoclonal antibody that binds to CCR5, a co-receptor that is the principal molecular portal used by HIV to enter and infect immune system cells. Some strains of | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| YALE UNIVERSITY | $240,162 | Grant | Trans-NIH Recovery Act Research Support: The pattern of activity in the circuits of the brain and their experience-dependent changes underlie the processing of sensory information, perception, and motor control. Much has been learned about the anatomical wiring of brain circuits and about the pr | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| BOSTON MEDICAL CENTER CORPORATION | $85,500 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this project is to co-locate a recent master's degree graduate in EHS to perform two essential roles: (1) provide on-site supervision to the EHS caseworkers who are principally responsible providing Problem Solving Therapy (the therapeutic | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF ILLINOIS | $108,000 | Grant | Trans-NIH Recovery Act Research Support: The proposed supplement is consistent with the NIMH priority area of G?Retaining post-doctoral fellows and early stage investigators in the field of mental health research.G? Funds from this administrative supplement will be used to create a full-time po | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| RUSH UNIVERSITY MEDICAL CENTER | $53,180 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of the administrative supplement to the parent grant, K23NS060949, G?ParkinsonG??s disease, cognitive impairment, and structural MRI,G? is to investigate the role of white matter microstructural integrity in ParkinsonG??s disease dementi | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $50,000 | Grant | Trans-NIH Recovery Act Research Support: The focus of my career in patient-oriented research (POR) has been to study how interactions between HIV- 1 and key cells involved in innate and adaptive immunity influence control of HIV-1 replication and disease progression. The ultimate goal of these s | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| BROWN UNIVERSITY IN PROVIDENCE IN STATE OF RI AND PROVIDENCE PLANTATIONS | $108,000 | Grant | Trans-NIH Recovery Act Research Support: Funding is sought for a five year mentored training period at Brown University for Dr. Nicola Neretti to transition from physics to independent investigator in computational biology. The candidate has a Physics PhD from Brown University, and has been work | Health and Human Services, Department of / National Institutes of Health | 9/02/2009 |
| CHILDREN'S RESEARCH INSTITUTE | $196,721 | Grant | Trans-NIH Recovery Act Research Support: Asthma is the most common chronic disease of childhood, and it disproportionately affects urban, minority, and disadvantaged children. When implemented correctly, existing evidence-based guidelines from the National Heart, Lung, and Blood Institute (NHLBI | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| NORTHWESTERN UNIVERSITY | $1,219,042 | Grant | Trans-NIH Recovery Act Research Support: Nephrogenic Systemic Fibrosis (NSF) is a disabling dermatologic adverse drug reaction associated with Gadolinium Containing Chelating Agents (GCCAs). Dermatologic adverse drug reactions (dADRs) are important and poorly characterized causes of morbidity an | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| RESEARCH TRIANGLE INSTITUTE | $955,027 | Grant | Trans-NIH Recovery Act Research Support: Similar to dopamine, glutamate regulation of the reward circuitry involves inputs to the ventral tegmental area and the nucleus accumbens. Functional dysregulation of the circuits has been proposed as neural substrates of drug dependence. Since neuroadapt | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| UNIVERSITY OF WASHINGTON | $675,290 | Grant | Trans-NIH Recovery Act Research Support: Serotonin is a neurotransmitter in the brain that plays an important role in complex behaviors including addiction. We have previously shown that 5 HT1B receptors alter the function of brain reward mechanisms that play a central role in addiction; these | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF NEBRASKA | $533,413 | Grant | Trans-NIH Recovery Act Research Support: For an individual, chronic tobacco use is associated with a significant increase in heart disease and many forms of cancer; the health of non-tobacco users is negatively affected by second- hand smoke. The potential benefits that would come from a better | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $705,751 | Grant | Trans-NIH Recovery Act Research Support: In that mucosal T lymphocytes are enmeshed in the complex and highly organized network of proteins, glycoproteins, and proteoglycans known as the extracellular matrix (ECM), we propose that the chronicity, exacerbation, and recurrence of IBD are multifact | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $866,251 | Grant | Trans-NIH Recovery Act Research Support: Obesity and Type 2 diabetes occurs with an alarming incidence in the United States, altogether affecting more than 120 million people, many of which are children. Currently, more people are obese and have diabetes in the world as compared to the number of | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $1,328,669 | Grant | Trans-NIH Recovery Act Research Support: The proposed research is focused on the development of high frequency dynamic nuclear polarization (DNP) nuclear magnetic resonance (NMR) as an approach to enhance sensitivity in solid state and solution NMR based structural biology experiments. In additi | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| WAYNE STATE UNIVERSITY (INC) | $759,997 | Grant | Trans-NIH Recovery Act Research Support: The specific aims are: 1) To establish the mechanism(s) of insulin activation of Akt on CYP2E1 gene transcription; 2) To examine the mechanism(s) by which insulin activation of mTOR regulates CYP2E1 mRNA translation and miRNA translation repression of deg | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF MONTANA SYSTEM | $135,985 | Grant | Trans-NIH Recovery Act Research Support: The specific aims of this investigation are threefold: 1) determine in wild-type yeast whether long-term immobilization alters chronological lifespan and global gene expression relative to aging planktonic cultures; 2) establish, relative to wild-type wh | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| CLEVELAND STATE UNIVERSITY | $67,938 | Grant | Trans-NIH Recovery Act Research Support: The synaptonemal complex (SC) is a proteinaceous scaffold that juxtaposes homologous chromosomes (homologs) during the pachytene stage of meiosis. Crossovers/chiasmata form in the context of the SC mediating homolog segregation to opposite spindle poles. | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| KALAMAZOO COLLEGE | $123,943 | Grant | Trans-NIH Recovery Act Research Support: Cytochrome P450 enzymes in humans are a family of heme-containing enzymes involved in metabolism of steroids, vitamins, eiconsanoids, and xenobiotics such as drugs, complex plant alkaloids, carcinogens, and other small molecules. With the sequencing of th | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| RFCUNY - BROOKLYN COLLEGE | $26,084 | Grant | Trans-NIH Recovery Act Research Support: To support small scale research projects conducted by faculty in primarily baccalaureate degree-granting domestic institutions. Awards are for up to $75,000 for direct costs (plus applicable indirect costs) for periods not to exceed 36 months. This grant | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | $5,429 | Grant | Trans-NIH Recovery Act Research Support: Body size can be altered by pituitary growth hormone, with the largest and smallest nonobese humans varying by about 10-fold in body mass. Organ sizes generally vary with body size, although there are indicators of local organ size regulation as well. A | Health and Human Services, Department of / National Institutes of Health | 7/10/2009 |
| BALDWIN WALLACE COLLEGE | $42,739 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Broad, long-term objectives: To reduce the burdens of illness and disability associated with learned fear responses that are part of post-traumatic stress disorder (PTSD) and phobias. To determine the neural mechanisms | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $218,818 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Herpes simplex virus type 2 (HSV-2) is a medically important pathogen worldwide, with a prevalence rate of over 20% in the US. The physical pain and psychosocial stress due to recurrent herpetic genital lesions have pr | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $67,636 | Grant | Trans-NIH Recovery Act Research Support: Streptococcus agalactiae (group B Streptococcus; GBS) is a leading cause of invasive infections such as pneumonia, sepsis, and meningitis in neonates. GBS is also an emerging cause of disease among the immunocompromised and elderly. Regulation of virulenc | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| MISSOURI SYSTEM, UNIVERSITY OF | $129,963 | Grant | Trans-NIH Recovery Act Research Support: In our original proposal, we set out to adapt genetic tools for working with the Category A select agent pathogen Yersinia pestis such that the use of antibiotic resistance markers could be reduced or eliminated. This research is necessary to enable progr | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| SOUTH DAKOTA STATE UNIVERSITY | $100,000 | Grant | Trans-NIH Recovery Act Research Support: Seeking additional funding to support out effort toward the discovery of inhibitors of influenza A virus RNA polymerase complex assembly by targeting PB1-PB2 and PA-PB2 interations, which fits well in the overall scope of the parent R21 grant. The supplem | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $96,400 | Grant | Trans-NIH Recovery Act Research Support: During the first phase of the AMDCC our group at TJU studied the decorin KO diabetic mouse. Our hypothesis was that decorin acts as an endogenous protective factor by inhibiting active TGF-b. We found that decorin is indeed protective, as decorin KO mice | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| UNIVERSITY OF CHICAGO, THE | $931,430 | Grant | Trans-NIH Recovery Act Research Support: We propose to increase the output of our modENCODE project by adding staff to collect chromatin and to produce transgenic BAC tagged transcription factors for which antibodies are not readily available, With current resources our annual production goal is | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $85,795 | Grant | Trans-NIH Recovery Act Research Support: Augment data submission and computational analysis with partial support for bioinformatics on our project. This position will prepare data for submission to the public modENCODE database (DCC). | Health and Human Services, Department of / National Institutes of Health | 9/26/2009 |
| THE VANDERBILT UNIVERSITY | $415,228 | Grant | Trans-NIH Recovery Act Research Support: The purpose of the original funding opportunity (RFA-HG-07-005: Genome-Wide Studies in Biorepositories with Electronic Medical Record Data (U01)) was to provide support to develop necessary methods for, and then to perform, genome-wide association studies | Health and Human Services, Department of / National Institutes of Health | 9/10/2009 |
| MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC. | $167,163 | Grant | Trans-NIH Recovery Act Research Support: Identification of G*E interaction terms for common diseases represents a top priority for the Gene Environment Association Studies (GENEVA) consortium of investigators. We propose a cohort specific, hypothesis-driven strategy to filter high throughput gen | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $980,581 | Grant | Trans-NIH Recovery Act Research Support: Purpose of Supplement. This administrative supplement complements the goals of the parent PAGE project. It provides funds to genotype additional susceptibility variants in approximately 2,500 African American study participants in CALiCo G?? PAGE. If the | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC. | $332,943 | Grant | Trans-NIH Recovery Act Research Support: Creating links between established researchers and aspiring scientists at the early college level is especially crucial to teach students skills necessary for research, to expose them to an enriching scientific environment, and to connect them to the next | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $212,831 | Grant | Trans-NIH Recovery Act Research Support: The proposed Rocky Mountain Taste and Smell Center (RMTSC) will encompass twelve principal investigators including scientists with a substantial record of accomplishment in the field of chemical senses as well as investigators with expertise in other area | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF WASHINGTON | $72,830 | Grant | Trans-NIH Recovery Act Research Support: This request is for a NIDCD Administrative Supplement to NIDCD P30 grant number DC04661 (UWResearch Core Center) as part of the American Recovery and Reinvestment Act of 2009. We seekseveral shared-use pieces of equipment through the NIDCD Supplement Oppo | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| FATHER FLANAGAN'S BOY'S HOME INC | $174,999 | Grant | Trans-NIH Recovery Act Research Support: This Core Center supplement has allowed us to hire a systems analyst-programmer who would accelerate both ongoing and future research projects by overcoming limitations in our locally developed data-collection and database software. A significant advantag | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC. | $449,688 | Grant | Trans-NIH Recovery Act Research Support: Core support for hearing researchThis supplement, will stimulate the economy by enabling hiring of additional programming staff for a period of two years. This new hire will increase the pace of science in the P30 Center by 1) allowing center PIs to offlo | Health and Human Services, Department of / National Institutes of Health | 6/30/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $297,903 | Grant | Trans-NIH Recovery Act Research Support: The Harvard Digestive Diseases Center (HDDC) is a consortium of 60 independent investigators with over $22 million annual research funding for research relevant to digestive diseases. 22 Associate Members approaching independence and over 200 trainees als | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $212,566 | Grant | Trans-NIH Recovery Act Research Support: The Center for the Study of Inflammatory Bowel Disease (CSIBD) is a multidisciplinary program to define fundamental mechanisms underlying Crohn?s disease and Ulcerative colitis. This Center encompasses seventy-two investigators at the Massachusetts Genera | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $159,584 | Grant | Trans-NIH Recovery Act Research Support: This project will address the role of adenovirus infection in the pathogenesis of asthma and cystic fibrosis | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF MARYLAND | $297,736 | Grant | Trans-NIH Recovery Act Research Support: The CNRU of Maryland will focus on the influence of nutrition and exercise on risk for age-related chronic diseases, including obesity, type 2 diabetes, hypertension, cardiovascular disease (CVD), sleep disordered breathing, and osteoporosis. With the obe | Health and Human Services, Department of / National Institutes of Health | 7/27/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $417,955 | Grant | Trans-NIH Recovery Act Research Support: Poor maternal dietary quality in the 1st trimester of pregnancy can alter the intrauterine nutritional environment and adversely affect placental development and subsequent fetal development and growth. The early months of pregnancy, when the placenta und | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| UNIVERSITY OF CONNECTICUT | $410,680 | Grant | Trans-NIH Recovery Act Research Support: Dementia, an age-associated clinical syndrome characterized by irreversible loss or decline in memory and other cognitive abilities, is a growing health problem. In 2008, an estimated 5.2 million Americans have Alzheimers disease (AD), which comprises abo | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| GEORGETOWN UNIVERSITY (THE) | $422,125 | Grant | Trans-NIH Recovery Act Research Support: Excessive activation of ionotropic glutamate receptors increases oxidative stress, which contributes to the neurodegeneration observed following neurological insults such as ischemia and seizures, as well as contributes to neuronal death in neurodegenerat | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| THOMAS JEFFERSON UNIVERSITY | $424,875 | Grant | Trans-NIH Recovery Act Research Support: Many neurodegenerative diseases, including spinal and bulbar muscular atrophy (SBMA) and ALS, result from protein misfolding and accumulation due to a variety of both genetic and environmental causes. SBMA is an adult-onset neuromuscular disease that is c | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| NORTHWESTERN UNIVERSITY | $400,475 | Grant | Trans-NIH Recovery Act Research Support: The control of every movement, whether it is a basic reflex or a sophisticated skill, is highly complex, involving the control of muscles distributed throughout the limb and body. This complexity is present whether movements are produced naturally by the | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF MIAMI | $420,750 | Grant | Trans-NIH Recovery Act Research Support: The project R21 NS 062669, entitled, G?HIV-1 infection: Central Serotonergic Activity and its Health ImplicationsG?, investigates the hypothesis that HIV-1 infection impacts the central serotonergic system in different brain regions and that the HIV-1 ind | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF KENTUCKY | $393,726 | Grant | Trans-NIH Recovery Act Research Support: Parkinson's disease (PD), the most frequent movement disorder, is caused by the progressive loss of the dopamine neurons in the midbrain in an area called substantia nigra pars compacta (SNc), resulting in a deficiency of the neurotransmitter dopamine in | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| WRIGHT STATE UNIVERSITY | $717,114 | Grant | Trans-NIH Recovery Act Research Support: Skeletal age is an important clinical tool in the management of children with growth disorders, genetic syndromes and those receiving hormonal, orthopedic or orthodontic treatments. It is also a useful epidemiological variable that helps to account for m | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $808,768 | Grant | Trans-NIH Recovery Act Research Support: Humanized transgenic mice reproduce the disease evolution of severe RA Rheumatoid arthritis (RA) is a common autoimmune disease found in close to 1% of the general population. Although some patients may have only moderate disease symptoms for long period | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) | $1,410,313 | Grant | Trans-NIH Recovery Act Research Support: Osteoarthritis (OA), the most common form of arthritis, is a slowly progressive degenerative disease of joint cartilage that afflicts 40 million Americans. Existing pharmacologic therapies (acetaminophen, non- steroidal anti-inflammatories (NSAIDs), & COX | Health and Human Services, Department of / National Institutes of Health | 6/29/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $543,789 | Grant | Trans-NIH Recovery Act Research Support: The long-term objective of our laboratory is to identify novel molecular targets for cancer. Kras is one of the most frequently mutated oncogenes in human cancer. Kras mutations are prevalent in lung, pancreas and colon carcinomas. We previously used mo | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $255,640 | Grant | Trans-NIH Recovery Act Research Support: (Also known as serine/threonine kinase 11, STK11) tumor suppressor is mutationally inactivated in Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder characterized by gastrointestinal polyps, mucocutaneous pigmentation, and a markedly increased r | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $401,940 | Grant | Trans-NIH Recovery Act Research Support: The lymphatic vasculature plays a critical role in the pathogenesis of many diseases including inflammatory disorders, lymphedema, tumor progression, and metastasis. More recently, the important role of lymphatic vessels in disease states such as tumor di | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $1,006,712 | Grant | Trans-NIH Recovery Act Research Support: In this proposal, we seek to develop a set of new tools to assess and enhance the efficacy of anti-cancer therapies that have immediate clinical relevance. In particular, we have developed and embedded methods for real-time quantitative parametric ultras | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $698,096 | Grant | Trans-NIH Recovery Act Research Support: The prognosis of patients with malignant gliomas remains dismal. To treat patients with this deadly disease more effectively, we must identify the common aberrations in the signaling pathways that are responsible for the invasive and drug-resistant nature | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $650,865 | Grant | Trans-NIH Recovery Act Research Support: For three decades, alterations of protein-coding oncogenes and tumor suppressors genes have been considered as the causes of tumorigenesis. Recent advances proved without doubts that cancer is a complex genetic disease involving structural and expression | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $599,398 | Grant | Trans-NIH Recovery Act Research Support: Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the United States and Europe. Recent progress in our understanding of CLL biology and the development of new therapy such as fludarabine-based regimens has led to improvements of the | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| HEALTH RESEARCH, INC. | $735,026 | Grant | Trans-NIH Recovery Act Research Support: The long-term objective is to determine the impact of environmental toxicants on the peripheral and central olfactory tissues, and the role of xenobiotic exposure in the etiology of anosmia and other diseases concerning the nasal cavity. Our focus continu | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $503,200 | Grant | Trans-NIH Recovery Act Research Support: Statistical Methods for Population Health Research on Chemical Mixtures. PI has moved to Harvard; grant to be transferred to Harvard. | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF LOUISVILLE | $740,000 | Grant | Trans-NIH Recovery Act Research Support: Glaucoma is one of the leading causes of blindness worldwide. Elevated intraocular pressure (IOP) is the primary risk factor for optic nerve damage in glaucoma. Many studies conducted on human subjects and animal models have shown that marijuana and its a | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $809,502 | Grant | Trans-NIH Recovery Act Research Support: The long-term goals are to comprehensively characterize extraocular muscles (EOMs) at the molecular level. Precise functioning of EOMs is an absolute requirement for optimal vision in humans. EOMs are highly specialized and undergo a wide range of reflexe | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC. | $735,993 | Grant | Trans-NIH Recovery Act Research Support: The major goal of this proposal is to identify biomarkers that could be used as eventual targets for prevention or therapeutic intervention of the development and progression of advanced age-related macular degeneration (AMD) using a phenotypically well c | Health and Human Services, Department of / National Institutes of Health | 8/19/2009 |
| SCHEPENS EYE RESEARCH INSTITUTE, INC., THE | $976,875 | Grant | Trans-NIH Recovery Act Research Support: Studies described in this proposal seek to elucidate thrombospondin-1 (TSP-1) mediated immune regulation and associated mechanisms that may prevent ocular inflammaton. The first aim seeks to determine immunologic mechanisms underlying ocular inflammatio | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $479,041 | Grant | Trans-NIH Recovery Act Research Support: ARRU - Enzymatic Mechanism of E. coli Helicases DNA helicases provide the primary mechanism by which duplex DNA is converted to single-stranded DNA (ssDNA) for use as a template in DNA replication and repair or as a substrate in recombination. Indeed, t | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| OHIO STATE UNIVERSITY, THE | $4,528,326 | Grant | Trans-NIH Recovery Act Research Support: Abstract Women's Health Initiative Sequencing Project (WHISP) The overall goal of this project submitted in response to NHLBI RC2 Topic 'Large-scale DNA Sequencing and Molecular Profiling of Well-phenotyped NHLBI Cohorts' (RFA-OD-09-004) is to identify pu | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | $107,974 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Multiple cell types are involved in the development and persistence of chronic inflammatory response. This also occurs in inflammatory bowel disease (IBD), where long-standing activation of immune and non-immune cells | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $38,217 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): In the past funding period, we have performed novel studies demonstrating an important role for Wnt signaling as an inhibitor of adipogenesis in cultured preadipocytes and in transgenic mice. Our studies have demonstra | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $100,500 | Grant | Trans-NIH Recovery Act Research Support: Therapeutic liver repopulation (TLR) is a process similar to bone marrow transplantation (BMT) resulting in replacement of > 90% of hepatocytes in the recipient liver by transplanted donor cells. Although TLR to date has been achieved experimentally only | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| CORNELL UNIVERSITY, INC | $26,410 | Grant | Trans-NIH Recovery Act Research Support: This is a request for a Recovery Act Administrative Supplement to support one summer undergraduate student and one faculty from a non-research intensive institution. The purpose of the supplement is to expand the scope and accelerate the pace of researc | Health and Human Services, Department of / National Institutes of Health | 6/23/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $80,986 | Grant | Trans-NIH Recovery Act Research Support: Renal failure is increasing at the rate of 6% with a cost of 16 billion dollars per year; thus developing new therapies for kidney disease is of paramount importance. In the previous renewal, we demonstrated that a loss of constitutive expression of vascu | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| UNIVERSITY OF TOLEDO, THE | $50,000 | Grant | Trans-NIH Recovery Act Research Support: We will continue studies of the role of CEACAM1 in insulin metabolism. CEACAM1 is a substrate of the insulin receptor kinase in the liver. In the first four years of funding, we have demonstrated that hepatic CEACAM1 plays a pivotal role in the formation | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF ROCHESTER | $99,698 | Grant | Trans-NIH Recovery Act Research Support: An elevation in the [Ca2+]i following secretagogue stimulation plays a fundamental role in underlying digestive enzyme secretion from the exocrine pancreas. The increase in [Ca2+]i is a tightly regulated event and exhibits characteristic temporal and spat | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF PITTSBURGH THE | $99,884 | Grant | Trans-NIH Recovery Act Research Support: Abnormal glomerular cell-extracellular matrix (ECM) adhesion, cytoskeleton organization and apoptosis are key factors in progressive glomerular failure. The goal of the parent project is to elucidate the molecular mechanisms by which glomerular cells con | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $100,001 | Grant | Trans-NIH Recovery Act Research Support: Choline is an essential nutrient that is derived from the diet, as well as from de novo synthesis of phosphatidylcholine catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). The human dietary requirement for choline has significant individual | Health and Human Services, Department of / National Institutes of Health | 8/24/2009 |
| ALBANY MEDICAL COLLEGE | $340,088 | Grant | Trans-NIH Recovery Act Research Support: The proper assembly of the mitotic spindle is essential for the segregation of genetic material during cell division. Mis-regulation of this process contributes to developmental abnormalities and tumor progression. Recent work from our laboratory has dem | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| PURDUE UNIVERSITY | $213,216 | Grant | Trans-NIH Recovery Act Research Support: The incorporation of HIV-1 protease inhibitors (PIs) in 1996 into combination therapy regimens with two or more reverse transcriptase inhibitors has been critical to the reduction of AIDS related mortality, improvement of quality of life, and enhancement | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| BRANDEIS UNIVERSITY | $243,968 | Grant | Trans-NIH Recovery Act Research Support: Local regulation of the levels and activity of synaptic proteins is critical to plasticity. In this proposal, we investigate the role of translation in regulation of the levels of CaMKII and characterize the functional roles of the interaction of Eag and | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $284,128 | Grant | Trans-NIH Recovery Act Research Support: Compelling new evidence indicates that a small RNA-mediated gene silencing pathway protects archaea and bacteria against viruses and other mobile genetic elements. This defense system, known as the CRISPR-Cas system or prokaryotic RNA interference (pRNAi | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| UNIVERSITY OF UTAH, THE | $264,392 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): A feature common to tumor cells is a high glycolytic rate. Increased glycolysis provides tumors with a selective growth advantage by supplying ATP to meet their high bioenergetic needs, and by supplying glucose-derived | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| SAINT LOUIS UNIVERSITY | $335,925 | Grant | Trans-NIH Recovery Act Research Support: Children with Cornelia de Lange syndrome (CdLS) display slow growth before and after birth, and are afflicted with mental retardation and defects in limbs and organs such as the heart. CdLS is caused by changes in genes that are also present in yeast and | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF UTAH, THE | $44,758 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Salmonella pathogens infect over a billion people each year worldwide resulting in 3 million deaths annually from septicemia, mostly in HIV-infected patients and 700,000 from typhoid fever (W.H.O. estimates). It is one | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $175,892 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Zinc is an essential nutrient because of the important roles this metal plays as a catalytic and structural cofactor. Several zinc-dependent proteins reside within organelles such as the endoplasmic reticulum (ER), Gol | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| SALK INSTITUTE FOR BLOGICAL STUDIES | $213,997 | Grant | Trans-NIH Recovery Act Research Support: This is a competitive continuation proposal to support three new aims of the project entitled Tertiary structures of potassium channel domains. This renewal proposal expands the scope and direction to a newer level by focusing on molecular working of 6 tr | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF SOUTH FLORIDA | $41,736 | Grant | Trans-NIH Recovery Act Research Support: The proposed International AIDS Research and Training Program is the collaborative effort of the University of South Florida (USF) and the University of Alabama at Birmingham (UAB) with Vadodara Medical College (VMC), Gujarat, India. The purpose of this i | Health and Human Services, Department of / National Institutes of Health | 9/02/2009 |
| DUKE UNIVERSITY | $19,344 | Grant | Trans-NIH Recovery Act Research Support: The fundamental scientific problem we propose to address is to determine the basic neural and molecular requirements for vocal learning, which is the behavioral substrate for spoken language, one of the essential behaviors that make us human. Spoken lang | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| BOSTON COLLEGE, TRUSTEES OF | $30,048 | Grant | Trans-NIH Recovery Act Research Support: The administrative supplement is for funds to increase the tempo of summer research in several key areas of parent NIH DP1OD003312. In particular, this grant is for hiring undergraduate students during summer months. During the summer 2009, we hired 10 | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $41,973 | Grant | Trans-NIH Recovery Act Research Support: Abstract In the fields of biomaterials and tissue engineering, the ability to modulate cell behavior on surfaces is essential, particularly when attempting to direct cell growth and differentiation, both for in vitro engineered tissue and generating cell | Health and Human Services, Department of / National Institutes of Health | 8/07/2009 |
| UNIVERSITY OF WASHINGTON | $601,670 | Grant | Trans-NIH Recovery Act Research Support: There are two scientific goals of this administrative supplement: 1) genotype 3441 copy-number polymorphisms (CNPs) among all 2060 DNA samples from the 1000 Genomes Project using array comparative genomic hybridization or arrayCGH and 2) experimentally ch | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| NEW YORK UNIVERSITY (INC) | $177,450 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of our research program continues to be the understanding of the neurobiological basis for motor control. More specifically, we aim at characterizing physiological properties of neurons and neuronal circuits that we consider crucial to | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON | $395,866 | Grant | Trans-NIH Recovery Act Research Support: This project requests continued support for the National Institute of Environmental Health Sciences (NIEHS) Center at the University of Texas Medical Branch (UTMB). The mission of this Center is to integrate, coordinate and foster interactions and collabo | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF OREGON | $786,872 | Grant | Trans-NIH Recovery Act Research Support: Expansion of the Zebrafish International Resource Center (ZIRC) Cryopreservation Program Zebrafish is a premiere organism to study vertebrate development, physiology, behavior, genetics, and disease. Powerful techniques allow efficient generation and re | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $793,813 | Grant | Trans-NIH Recovery Act Research Support: Though current computational models of visual processing provide a good account of processing of simple images such as lines and gratings, our understanding of the processing of natural scenes is substantially incomplete. Several lines of reasoning indica | Health and Human Services, Department of / National Institutes of Health | 6/19/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $70,443 | Grant | Trans-NIH Recovery Act Research Support: Hypoxic-ischemic (HI) encephalopathy is a common problem impacting thousands of Americans. Animal models have been created to allow for a greater understanding of the process and determine the efficacy of pharmaceutical agents. One of these is the hypoxia | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH | $108,000 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this proposed administrative supplement to the K23 parent grant entitled 'Osteopathic Manipulative Medicine in Pregnancy: Physiologic and Clinical Effects,? grant # 1K23AT003304, is to hire one additional full time research coordinator to e | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| MISSOURI SYSTEM, UNIVERSITY OF | $54,000 | Grant | Trans-NIH Recovery Act Research Support: This project combines 1) in vivo, retrospective assessment of the severity of any post-radiation dental lesions as related to factors such as radiation field parameters, the radiation dose to which teeth were exposed, and the use of salivary gland radiati | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UMDNJ-ROBERT WOOD JOHNSON MEDICAL SCHOOL | $99,440 | Grant | Trans-NIH Recovery Act Research Support: This randomized double-blind placebo controlled trial uses a translational research technique (sublingual microcirculatory videomicroscopy during protocol-directed resuscitation), to directly measure microcirculatory blood flow in patients with potential | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE | $292,538 | Grant | Trans-NIH Recovery Act Research Support: This is a request to purchase a high resolution, high mass accuracy tandem mass spectrometry system for proteomics analyses. The mass spectrometer will be equipped with a nanoflow liquid chromatography system and chip based electrospray interface. The ins | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| LOYOLA UNIVERSITY | $147,729 | Grant | Trans-NIH Recovery Act Research Support: Interest in changes and deficiencies of the immune system during the aging process has gained momentum in recent years. It is now realized that an adequate comprehension of healthy aging requires more foundational knowledge about how to enhance and contro | Health and Human Services, Department of / National Institutes of Health | 5/19/2009 |
| WAKE FOREST UNIVERSITY | $228,363 | Grant | Trans-NIH Recovery Act Research Support: Our programmatic goal is to provide for an integrated career development pathway in clinical aging research for both physician and non-physicians. We are requesting funds to support establishment of a geriatric fellow / post-doctoral training program desi | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF ILLINOIS | $2,085,844 | Grant | Trans-NIH Recovery Act Research Support: Ebola and Marburg viruses belong to the family Filoviridae and can cause fatal hemorrhagic fevers characterized by widespread tissue destruction with an incubation period of 4-14 days. Because of the safety concerns, these viruses are designated as the bi | Health and Human Services, Department of / National Institutes of Health | 9/12/2009 |
| UNIVERSITY OF MARYLAND | $1,137,892 | Grant | Trans-NIH Recovery Act Research Support: Following the anthrax bioterror attacks in the US in 2001, awareness of the potentially devastating effects of attack with a bioweapon led to recognition of the need to take action and prepare against possible future nefarious events. F. tularensis was pl | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| TEXAS A & M UNIVERSITY SYSTEM HEALTH SCIENCE CENTER RESEARCH | $13,185 | Grant | Trans-NIH Recovery Act Research Support: The parent greant (R01 DE016059) was awarded by NICDR/NIH for research on the Sex Steroids and TMJ Pain. This supplement provides short-term research experience for two college graduates during the summer preceding their entry into the first year of the | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| FORSYTH DENTAL INFIRMARY FOR CHILDREN | $316,252 | Grant | Trans-NIH Recovery Act Research Support: The focus of this supplement is to determine if cathepsin K is essential for proper dental enamel formation. The parent grant focused on defining how enamelysin (matrix metalloproteinase-20; MMP20) processes enamel proteins and focused on determining how | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $16,936 | Grant | Trans-NIH Recovery Act Research Support: This grant provided a summer research experience for two college studnets, science educators in health-related sceintific research. The major task of this administrative supplemental grant application is to provide basic research training opportunity by h | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| AMERICAN DENTAL ASSOCIATION FOUNDATION | $17,400 | Grant | Trans-NIH Recovery Act Research Support: The combination of technological advances in Dental materials and increased demands in quantity and quality by a burgeoning population of dentate elderly has resulted in the production of new Dental restoration systems at an unprecedented pace. Longevity | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| DUKE UNIVERSITY | $261,103 | Grant | Trans-NIH Recovery Act Research Support: This Administrative Supplemental Revision is in response to notice number (NOT-OD-09-058). Notice Title: NIH announces the availability of recovery act funds for administrative revision applications. The parent grant, R01DE018549, has the objective of det | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE | $37,287 | Grant | Trans-NIH Recovery Act Research Support: Regulation of Sinusoidal Perfusion in Shock Altered hepatic vascular regulation is a common event following shock or sepsis. Recent work shows that this is related to increased constrictor response to endothelin that is associated with decreased eNOS ac | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | $52,045 | Grant | Trans-NIH Recovery Act Research Support: Lipid Transport in the Intestine Fatty acids (FA) and monoacylglycerol (MG) are the primary hydrolytic products of dietary triacylglycerol (TG). Substantial gaps remain in our understanding of the basic mechanisms of MG and FA assimilation by the intestin | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $20,328 | Grant | Trans-NIH Recovery Act Research Support: A major challenge facing biomedical research is to determine how the network of interactions involving gene regulatory proteins is controlled in the context of the natural environment inside living cells, and to understand how disease processes affect the | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $166,752 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The low-affinity Na+/dicarboxylate cotransporter NaDC1 is found on the apical membrane of the renal proximal tubular epithelium, where it plays an important role in the reabsorption of citric acid cycle intermediates, | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF MARYLAND | $50,000 | Grant | Trans-NIH Recovery Act Research Support: Antibiotic resistance is an increasing public health problem that is associated with considerable morbidity, mortality and costs. Given the reduced pace of antibiotic discovery and the approaching demographic shift towards an increasingly aged population, | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $49,991 | Grant | Trans-NIH Recovery Act Research Support: The proposal requests the support of a geographic and mathematical postdoctoral researcher to support and advance the research described in the parent K01 project Mathematical Techniques for Control of Epidemic Trypanosoma cruzi Transmission (1K01AI079162 | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE, INC. | $108,000 | Grant | Trans-NIH Recovery Act Research Support: The AKT signaling pathway is important for the survival of multiple myeloma cells (MM). An important downstream target of AKT is the mammalian target of rapamycin (mTOR), which mediates phosphorylation of p70 and 4E-BP1, factors responsible for ribosome b | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO | $50,000 | Grant | Trans-NIH Recovery Act Research Support: This supplemental award provides support for the salaries of two postdoctoral research fellows under the project Bone-Seeking Proteasome Inhibitors for Myeloma. | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| THE VANDERBILT UNIVERSITY | $100,000 | Grant | Trans-NIH Recovery Act Research Support: Tumor progression toward a malignant, metastataic disease state involves complex interactions between tumor cells and the host microenvironment, including vascular endothelium. My research centers on understanding the role of EphA2 receptor tyrosine kinas | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $100,000 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The proposed plan for this NCI Mentored Career Development for Underrepresented Minorities K01 award is a two-year Mentored Phase, followed by a three-year Independent Phase. The Mentored Phase will provide for advance | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $101,679 | Grant | Trans-NIH Recovery Act Research Support: My primary goal is to understand how mutational activation of K-RAS induces high grade dysplasia early during the malignant progression of colorectal cancer. My working hypothesis is that mutant K-RAS signals through the B-RAF kinase to suppress the diffe | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| NEW YORK UNIVERSITY (INC) | $54,000 | Grant | Trans-NIH Recovery Act Research Support: Signaling by the Notch receptors has been implicated in maintenance and differentiation of the pluripotent progenitor cells in the mammalian pancreas, intestine and vasculature. Within the parent grant, we have shown that during branching morphogenesis of | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF WASHINGTON | $53,972 | Grant | Trans-NIH Recovery Act Research Support: The primary goal of this proposal is to engage fund that supports a technical assistant to work on the projects funded under an active NIH/NIDDK K01 Award (DK 075665). The objective of the parent K01 award is to train and bridge the principal investigato | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $54,000 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Gram-negative enteropathogenic bacteria, including Yersinia, Salmonella, Shigella and both enteropathogenic and enterohemorrhagic E. coli, cause a wide variety of gastero intestinal diseases in humans. All of these pat | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY OF PITTSBURGH THE | $107,998 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this project is to hire an additional research assistant to enhance the goals of a career development award entitled Media Literacy to Prevent Adolescent Smoking. The hired individual will assist with data collection, analyses, and manuscri | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $106,338 | Grant | Trans-NIH Recovery Act Research Support: The overarching goal of this proposal is to develop an innovative, comprehensive curriculum designed to increase medical students' knowledge and skills in the behavioral and social sciences (BSS) related to health. Curriculum development in this area will | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| RHODE ISLAND HOSPITAL | $65,205 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement to my K07 'Measuring Preference for Fertiloity in Breast Cancer for a Decision Aid' will create a fully web-based interactive decision aid for newly diagnosed breast cancer patients to make fertility preservation decisions, | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| THE GEORGE WASHINGTON UNIVERSITY | $78,744 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement is intended to accelerate the pace of research and enhance the quality of research associated with the funded K07 entitled Using Tailored Email Messages to Enhance Phone Counseling at a Smoking Cessation Quitline. The K07 re | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| WAYNE STATE UNIVERSITY (INC) | $106,860 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of the proposed administrative supplementis to hire a laboratory technician to assist with the genotyping of samples from bladder cancer cases and controls in order to accelerate the scientific pace and enhance the scope of a funded, earl | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| DUKE UNIVERSITY | $49,999 | Grant | Trans-NIH Recovery Act Research Support: This program will prepare Amy M. Pastva, PT, PhD, CCS, for a career as an independent clinician-scientist in academic research medicine, specializing in the study of allergic lung disease. Dr. Pastva has been pursuing rigorous training in cell biology and | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $29,011 | Grant | Trans-NIH Recovery Act Research Support: This project is to examine the biological function of the N-terminus of the IkappaBalpha protein. We have generated expression constructs of normal IkappaBalpha and IkappaBalphaW11X, which lacks the N-terminal 12 amino acids of IkappaBalpha. These expre | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| THE WASHINGTON UNIVERSITY | $48,826 | Grant | Trans-NIH Recovery Act Research Support: Relevance to NIAID mission: This application describes a 5-year training program for the development of an academic career in Pediatric Infectious Diseases, with a goal of independently directing research into parasite biology, pathogenesis, and therapy. | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $48,419 | Grant | Trans-NIH Recovery Act Research Support: The PI is investigating the role of Notch1 and Trib-2 proteins in macrophage fusion and granuloma formation. Three novel Notch-modified transgenic animals were generated by the Principal Investigator, and a Trib2 knock-out animal was recently generated in | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| UNIVERSITY OF WASHINGTON | $50,000 | Grant | Trans-NIH Recovery Act Research Support: This proposal describes a two-year Administrative Supplement to my five-year mentor training program to develop an independent clinician-scientist for a career in academic medicine and gene therapy. The application will further advance my research in the | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| THE VANDERBILT UNIVERSITY | $54,000 | Grant | Trans-NIH Recovery Act Research Support: This is an application for an Administrative Supplement (NOT-OD-09-056) for my funded proposal G?TRAIL Mediated Apoptosis in Renal Cell CarcinomaG? (K08 CA113452). The parent grant hypothesized that the type I interferon, IFNa, could modulate the sensitiv | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| NEW YORK UNIVERSITY | $54,000 | Grant | Trans-NIH Recovery Act Research Support: This supplement provides support to retain a project technician. This work has far reaching implications in the physiology and pathophysiology of skeletal tissues. Alterations in chondrocyte maturation and hypertrophy have catastrophic physiologic and qu | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $48,695 | Grant | Trans-NIH Recovery Act Research Support: The success of TNF blockade for the treatment of Crohn's disease (CD) has lead to the systematic study of other biological therapies. Unfortunately, the usefulness of these newer therapies (e.g. IL-10, IL-11 blockade) has been limited. Therefore, alternat | Health and Human Services, Department of / National Institutes of Health | 7/31/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $49,680 | Grant | Trans-NIH Recovery Act Research Support: Based on my K08 hypothesis that selective combinations of adhesion molecule expression identifies subsets of T cells that preferentially home to the colon and results from the K08 aims, we identified not one but two candidate chemokine receptor genes that | Health and Human Services, Department of / National Institutes of Health | 8/24/2009 |
| NORTH DAKOTA STATE UNIVERSITY | $434,280 | Grant | Trans-NIH Recovery Act Research Support: The goal of the parent grant is to establish a Center for Visual and Cognitive Neuroscience at North Dakota State University. Emerging from the Center projects is a translational and collaborative project that aims to determine whether training on attenti | Health and Human Services, Department of / National Institutes of Health | 9/26/2009 |
| TEXAS AGRILIFE RESEARCH | $39,456 | Grant | Trans-NIH Recovery Act Research Support: Despite significant efforts to educate women to not drink during pregnancy, the incidence of Fetal Alcohol Spectrum Disorders has not declined making it important to obtain understanding of the mechanisms by which prenatal alcohol exposure causes neurode | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $50,961 | Grant | Trans-NIH Recovery Act Research Support: Alcoholism and alcohol abuse are complicating factors in most chronic medical and psychiatric illnesses. Alcohol physiological dependence and associated withdrawal episodes are thought to constitute a powerful motivational force that perpetuates continued | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC. | $129,740 | Grant | Trans-NIH Recovery Act Research Support: Acute alcoholic hepatitis is a severe disease that has a poor outcome and limited therapeutic approaches. Hepatitis C infection worsens the outcome of alcoholic liver disease and there are limited therapeutic approaches. Ongoing studies have determined th | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| VIRGINIA COMMONWEALTH UNIVERSITY | $109,847 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement will allow us to accelerate the tempo of our research by hiring assitional staff. The long-term objectives of this project are to investigate the mechanisms regulating neural regeneration and to develop strategies to enhance | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $181,924 | Grant | Trans-NIH Recovery Act Research Support: The nasal cavity in mammals houses distinct chemosensory epithelia including the main olfactory epithelium, the vomeronasal epithelium and the trigeminally innervated respiratory epithelium (so-called 'non- sensory' epithelium) (Finger et al., 2000). Each | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF ROCHESTER | $180,061 | Grant | Trans-NIH Recovery Act Research Support: The supplement allows us to perform experiments related to the first specific aim of the grant but which were not proposed originally. Our novel findings related to the linearity of central vestibular neuronal responses will be further developed using ne | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $207,946 | Grant | Trans-NIH Recovery Act Research Support: Radiofrequency (RF) and microwave ablation techniques are interstitial, focal ablative therapies that can be used in a percutaneous fashion. They permit in situ destruction of hepatic, renal and prostatic tumors. However, local recurrence rates after RF | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $326,851 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement proposes to accelerate the pace of research under the existing scientific aims of our successful project, ?NSAID and COX/PG Metabolism and Colorectal Cancer? (R01 CA112516) by incorporating more complete information on genet | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $99,950 | Grant | Trans-NIH Recovery Act Research Support: Of the over 200,000 men estimated to be diagnosed with prostate cancer in 2010 in the U.S, almost one half will undergo radical prostatectomy (RP) for treatment of their disease. As many as 25% or more men who undergo this treatment will experience a re-e | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | $98,930 | Grant | Trans-NIH Recovery Act Research Support: Prostate Cancer is the most common malignancy in American men claiming about 40,000 lives per year. Metastatic prostate cancer is not curable and is associated with a mean survival of 2-3 years. The progression of localized prostate cancer to metastatic a | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| VIRGINIA COMMONWEALTH UNIVERSITY | $250,000 | Grant | Trans-NIH Recovery Act Research Support: In line with the goals of the ARRA, we are requesting supplement funding for the hiring of two fellows to (a) advance the supply of functionalized metallofullerenes (f-MFs) and (b) accelerate tumor targeting basic science results to date. One fellow will | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $131,760 | Grant | Trans-NIH Recovery Act Research Support: This application details a three-year renewal of a K01 International Research Scientist Career Development Award focused on identifying human gene polymorphisms related to Vibrio cholerae infection. The program will be conducted under the collaborative me | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| UNIVERSITY OF WASHINGTON | $780,000 | Grant | Trans-NIH Recovery Act Research Support: The long-term objectives of this proposal are to fully define the molecular genetics of human color vision and its common defects, and to elucidate the mechanisms of regulation of expression of the X-linked red-green color vision locus. A remarkable heter | Health and Human Services, Department of / National Institutes of Health | 8/19/2009 |
| UNIVERSITY OF ARIZONA | $743,258 | Grant | Trans-NIH Recovery Act Research Support: A molecular component involved in the pathogenesis of open-angle glaucoma has been identified. Mutations causing ocular hypertension and open-angle glaucoma in some are located to a glaucoma gene on a chromosome 1 locus, GLC1A, that codes for a protein ca | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| UNIVERSITY OF NOTRE DAME DU LAC | $746,750 | Grant | Trans-NIH Recovery Act Research Support: The goal of the proposed research is to understand the roles of centrifugal input in vertebrate retinas. In all vertebrates (include humans), the retinas receive centrifugal input from the brain. In fish, the centrifugal input originates from the terminal | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| NEMOURS FOUNDATION | $332,375 | Grant | Trans-NIH Recovery Act Research Support: Localization of mRNAs with subsequent translation into new proteins provides a means to geographically regulate neuronal protein composition in distinct subcellular regions. In axons, this localized protein synthesis is needed for growth cone guidance and | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| WAKE FOREST UNIVERSITY | $51,983 | Grant | Trans-NIH Recovery Act Research Support: Alcohol abuse continues to be a major problem in the United States with an estimated 14 million adults meeting the clinical criteria for a diagnosis of alcohol abuse or alcoholism at an estimated cost of $185 billion. Chronic alcohol exposure has been sho | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $308,852 | Grant | Trans-NIH Recovery Act Research Support: Dopaminergic transmission in the brainG??s mesocorticolimbic system is thought to be a significant factor in alcohol abuse and dependence. Most research on the dopaminergic response to alcohol and its conditioned cues is nevertheless done in rodents. The | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $36,508 | Grant | Trans-NIH Recovery Act Research Support: Habits and cues in alcohol drinking: Dynamic striatal activity - ARRA This grant is an administrative supplement in response to NOT-OD-09-060 G?NIH Announces the Availability of Recovery Act Funds for Administrative Supplements Providing Summer Research | Health and Human Services, Department of / National Institutes of Health | 7/10/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $11,211 | Grant | Trans-NIH Recovery Act Research Support: Many older adults are less steady when exerting low forces and lifting light loads. The greater fluctuations in force exhibited by older adults can be caused either by increased discharge rate variability or by altered amounts of correlated activity among | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $3,350,000 | Grant | Trans-NIH Recovery Act Research Support: End stage renal disease (ESRD), one of the most serious and costly complications of systemic lupus erythematosus (SLE), occurs in a sub-set of patients with SLE-related renal involvement. Factors predisposing to ESRD presumably include both genetics and | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| CHILDRENS HOSPITAL OF PHILADELPHIA | $49,607 | Grant | Trans-NIH Recovery Act Research Support: This application describes a comprehensive training program designed to transition Dr. Ryan from a mentored scientist into an independent investigator in the area of Pediatric Gl and Hepatology studying the role of the Notch signaling pathway in liver and | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $50,000 | Grant | Trans-NIH Recovery Act Research Support: This is an administrative supplement application for a mentored clinical scientist development award (K08) to conduct genetic and functional studies of the vesicular monoamine transporter 1 (VMAT1 SLC18A1) gene on chromosome 8p21 implicated in susceptibil | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $59,833 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Presbycusis, age-related hearing loss, is a major reason for social isolation and loss of quality of life in the elderly but we have neither a clear understanding of the mechanisms involved nor of strategies to prevent | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $0 | Grant | Trans-NIH Recovery Act Research Support: These studies provide fundamental and basic insights into new pathways through which the immune system responds to organ and tissue transplants. The results of these studies will be useful in the design and implementation of strategies into the clinical c | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| JOHN WAYNE CANCER INSTITUTE | $3,080,000 | Grant | Trans-NIH Recovery Act Research Support: The overall purpose of this award is to fund the conduct of an in-progress research study. The purpose of the research study is to understand if surgery as a first treatment for Stage IV melanoma will lengthen the survival time compared to non-surgical ( | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| BAYLOR COLLEGE OF MEDICINE | $176,495 | Grant | Trans-NIH Recovery Act Research Support: This supplement will allow for replacement of aging equipment and purchase of new equipment that will significantly improve the quality of research, and has allowed retention of 2 employees. The main goal of the current P01 proposal, which is in its 28th | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $200,002 | Grant | Trans-NIH Recovery Act Research Support: This grant proposal focuses our sustained laboratory and clinical research experience in animal and human stem cell biology and leukemia to extend exciting new investigations on normal tissue-specific and cancer stem cells. The investigators in this PPG l | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| MAYO CLINIC | $453,300 | Grant | Trans-NIH Recovery Act Research Support: Diabetic gastroparesis is a serious and debilitating complication of diabetes. In the parent grant to this application, we have tested the central hypothesis that interstitial cells of Cajal (ICC) and neuronal nitric oxide synthase (nNOS) are lost in diab | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $250,000 | Grant | Trans-NIH Recovery Act Research Support: A complex interaction of different processes play a critical role in the development of hematopoietic lineages, and among the most important are the controls of hematopoietic stem cell (HSC) commitment. Understanding this process is critical to understand | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $500,001 | Grant | Trans-NIH Recovery Act Research Support: MITOCHONDRIAL GENETIC DETERMINANTS OF HUMAN PARTURITION AND PRETERM BIRTH The processes underlying human parturition and etiology of preterm birth are not well-understood. There has been an intense focus in recent years on studies of the complex interact | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| BRANDEIS UNIVERSITY | $87,264 | Grant | Trans-NIH Recovery Act Research Support: Animal behavior is both stable and plastic. To these ends, molecules and neural circuits respond to environmental changes, both short-term and long-term pertubations. In some cases, the responses maintain a fixed behavior despite a radically altered exter | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF TEXAS AT EL PASO | $61,295 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to enhance the pipeline for Underrepresented Minorities Students toward a career in Radiation Oncology Physics (supported by our parent grant) by implementing a novel outreach program for the high-school and Community College s | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $420,206 | Grant | Trans-NIH Recovery Act Research Support: We originally proposed an 14 month, milestone-driven, benchmarked research plan that extends a parent P20 Center grant focusing on bio-therapeutics development. The research was proposed to be executed by 6 newly hired academic research and technical posi | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| FLORIDA INTERNATIONAL UNIVERSITY | $600,000 | Grant | Trans-NIH Recovery Act Research Support: This proposed project targeting Hispanic migrant workers in South Florida, is a 2-year CBPR-based research education program with the goal of building the knowledge and skills needed at the community level to develop and sustain an effective CBPR partners | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF ARKANSAS SYSTEM | $656,040 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this grant is to provide undergraduate students and high school and small college teachers with a research experience working with our COBRE investigators during the summers of 2009 and 2010. The research to be carried out by these stude | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $281,041 | Grant | Trans-NIH Recovery Act Research Support: General purpose of the award was to create education and research experience opportunities in the general area of developmentally-based cardiovascular disease for: 1) undergraduate college students; and, 2) Secondary school science educators | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $567,951 | Grant | Trans-NIH Recovery Act Research Support: The proposal is to underwrite the expansion of a nascent core facility (DartMouseTM) recently initiated with Dartmouth COBRE seed funds. DartMouse supports the development of 'speed' congenic mice for COBRE investigators at Dartmouth. In pre-clinical stud | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| SOUTH CAROLINA RESEARCH FOUNDATION | $245,003 | Grant | Trans-NIH Recovery Act Research Support: SC IDEA NETWORK OF BIOMEDICAL RESEARCH EXCELLENCE Consistent with the original SC INBRE design, the proposed biomedical research activities will be conducted by collaborative teams. The aims of this supplement are to obtain preliminary data to strengthen | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF NORTH DAKOTA | $135,000 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The North Dakota INBRE has succeeded beyond all reasonable expectations in fulfilling the IDeA program's goal of establishing an undergraduate research culture in the state's primarily undergraduate institutions (PUIs | Health and Human Services, Department of / National Institutes of Health | 7/10/2009 |
| MARSHALL UNIVERSITY RESEARCH CORPORATION | $590,453 | Grant | Trans-NIH Recovery Act Research Support: West Virginia is a State that has had a historically low success rate in obtaining grant awards from the National Institutes of Health and has been designated as an IDeA State. Marshall University (MU), in partnership with West Virginia University (WVU), | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| NEW MEXICO STATE UNIVERSITY | $529,202 | Grant | Trans-NIH Recovery Act Research Support: The overarching goal of the New Mexico Idea Network of Biomedical Research Excellence (NM-INBRE) is to strengthen biomedical research in New MexicoG??s institutions of higher education and to prepare faculty and students for participation in the research | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE | $283,960 | Grant | Trans-NIH Recovery Act Research Support: Hypertension is a leading cause of death and disability affecting over 50 million people in the United States and responsible for 200,000 deaths annually. Because hypertension and associated cardiovascular diseases are prevalent in Louisiana, Tulane Healt | Health and Human Services, Department of / National Institutes of Health | 8/19/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $49,645 | Grant | Trans-NIH Recovery Act Research Support: This award is to assist with a project to adopt new technologies which is intended to improve the efficiency and effectiveness of the clinical trials process and reduce clinical trial costs, thereby realizing the ultimate goal of more rapid progress again | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF PITTSBURGH THE | $2,934,725 | Grant | Trans-NIH Recovery Act Research Support: UPCI plans to further develop the Clinical Disease Site Programs. To develop translational research of these programs, UPCI intends to recruit new translationally-oriented physician-scientist faculty members and support their career development. The Admin | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| THE VANDERBILT UNIVERSITY | $46,532 | Grant | Trans-NIH Recovery Act Research Support: Cancer represents a complex set of diseases originating from normal cells with many genetic and epigenetic defects present prior to any treatment. The infrastructure that the Human Tissue Acquisition and Pathology Shared Resource (HTAP) offers in the acqu | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $50,000 | Grant | Trans-NIH Recovery Act Research Support: The OHSU Cancer Institute is a matrix cancer center at Oregon Health & Science University (OHSU) in Portland, Oregon. In 1992, OHSU president Dr. Peter Kohler, committed to developing excellence in fundamental cancer research in this University, appointed | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF IOWA, THE | $1,450,000 | Grant | Trans-NIH Recovery Act Research Support: The University of Iowa Holden Comprehensive Cancer Center (HCCC), a matrix cancer center at the University of Iowa, is applying for renewal of its Cancer Center Support grant. This is the first competitive renewal application for the HCCC. The Cancer Cent | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| THE WASHINGTON UNIVERSITY | $32,780 | Grant | Trans-NIH Recovery Act Research Support: The Research Center for Auditory and Vestibular Studies, a P30 Core Center Grant, was established in 2001 to meet the specialized needs of hearing and balance researchers at Washington University and surrounding St. Louis area institutions. The developme | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $300,000 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION, OVERALL (provided by applicant): Recent advances in basic research techniques have led to an explosion of information and interest in the role of gastrointestinal peptides in health and disease. The function of these peptides has been shown t | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| WASHINGTON UNIVERSITY, THE | $298,601 | Grant | Trans-NIH Recovery Act Research Support: The overarching goal of the Washington University WU Center for Kidney Disease Research (CKDR) is to support centralized resources, facilities, and expertise shared by investigators at WU in order to delineate fundamental mechanisms of renal disease and t | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| UNIVERSITY OF CALIFORNIA, SANTA CRUZ | $690,000 | Grant | Trans-NIH Recovery Act Research Support: The UCSC Genome Browser (genome.ucsc.edu) is a vital resource for the biomedical community, providing timely, convenient access to sequence and annotations for the human and all other vertebrate reference species genomes, along with selected model inverte | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $542,664 | Grant | Trans-NIH Recovery Act Research Support: Genetic variation forms the basis of evolution and human diversity. Data from the Human Genome Project originally suggested that any two humans are 99.9% identical in their DNA sequences. The genetic variation that exists between individuals is thought to | Health and Human Services, Department of / National Institutes of Health | 9/10/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $249,897 | Grant | Trans-NIH Recovery Act Research Support: This request responds to Notice Number (NOT-OD-09-058) / Notice Title (NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications). It is a competitive revision to P41 LM005799. BioMagResBank (BMRB) is the unique worldwide | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $922,558 | Grant | Trans-NIH Recovery Act Research Support: Implementation of a web-based version of S.A.G.E. (Statisitcal Analysis for Genetic Epidemiology), preparation of a version of the S.A.G.E. short course suitable for clinical scientists to be given locally, development of a program to detect gene-gene int | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC. | $999,850 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this research is to study alterations in the brain in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease with magnetic resonance imaging (MRI). The proposals in this research amendment all aim at developing novel M | Health and Human Services, Department of / National Institutes of Health | 8/24/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $251,298 | Grant | Trans-NIH Recovery Act Research Support: This award is a supplemental grant to the Center of Research Translation (PI: Kevin Cooper), to enable the conduct of FDA-required animal/pre-clinical toxicologic studies on the investigational drug silicon phthalocyanine Pc 4. One of the goals of the COR | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| THE VANDERBILT UNIVERSITY | $49,580 | Grant | Trans-NIH Recovery Act Research Support: We propose to provide research experiences for up to 3 undergraduate students and one high school student for the summer of 2009, with the request to repeat this in summer of 2010. We believe that molecular imaging in cancer is a multi-faceted, multidisci | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| MONELL CHEMICAL SENSES CENTER | $659,349 | Grant | Trans-NIH Recovery Act Research Support: Funds were requested to accelerate research in the Projects of the Monell-Jefferson Chemosensory Clinical Research Center (CCRC) through the retention and hiring of highly skilled individuals and the continuation and expansion of patient recruitment effor | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| THE VANDERBILT UNIVERSITY | $293,694 | Grant | Trans-NIH Recovery Act Research Support: To meet the goals of the American Recovery Act, and also accelerate discovery for our research goals, we aim to hire 2 new additional research assistants and a new postdoctoral fellow, with partial support of yet another fellow. We also request funds to s | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC. | $300,000 | Grant | Trans-NIH Recovery Act Research Support: The Kansas Interdisciplinary Center for PKD Research (Kansas PKD Center) was established to provide support for highly meritorious new research programs to explore the basic mechanisms causing polycystic kidney disease (PKD); to provide opportunities to | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $9,512 | Grant | Trans-NIH Recovery Act Research Support: This project exposed an undergraduate student to basic science research. The student wored under the direct supervision of a senior Research Associate in the Department. He carried out a project comparing available antibodies to the four rodent and two hu | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $140,237 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The Specialized Program of Translational Research in Acute Stroke (SPOTRIAS) at the University of California San Diego (UCSD) Stroke Center currently applies the resources of 4 Cores to conduct 3 interrelated clinical | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $92,803 | Grant | Trans-NIH Recovery Act Research Support: The specific aims of this administrative supplement to the Neuroprotection with Statin Therapy for Acute Recovery Trial (NeuSTART) are to put the procedures in place to expand our Phase 2 study of lovastatin at doses of 640 mg daily in acute ischemic stro | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $881,965 | Grant | Trans-NIH Recovery Act Research Support: Nonhuman primate (NHP) models area essential to the conduct of translational research and the advancement of biomedical science. There is a critical need to increase the NHP housing and research capacity to address major human health threats. The Oregon N | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| EMORY UNIVERSITY | $494,676 | Grant | Trans-NIH Recovery Act Research Support: The focus of the present proposal is related directly to the component of our P51 parent grant intended to enhance research studies applicable to the solution of human health problems, i.e., translational research. Specifically, we are requesting funds to | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF WASHINGTON | $983,878 | Grant | Trans-NIH Recovery Act Research Support: The Division of Functional Genomics and Infectious Disease at the Washington National Primate Research Center (WaNPRC) is focused on developing high-throughput genomic and proteomic technologies, sophisticated immunologic resources, and advanced computing | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $921,484 | Grant | Trans-NIH Recovery Act Research Support: Electronic record systems are becoming the standard for healthcare organizations. The benefits of an EHR system are far-reaching, including improvements in animal care, cost-savings and increased efficiency. Creating the infrastructure to store animal rec | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| TEXAS BIOMEDICAL RESEARCH INSTITUTE | $1,703,813 | Grant | Trans-NIH Recovery Act Research Support: This is a National Center for Research Resources (NCRR) Base Grant Administrative Supplement to Advance Translational (T1 & T2) Research by supporting enhancement and integration of the nonhuman primate databases at the Southwest National Primate Research | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| THE VANDERBILT UNIVERSITY | $505,738 | Grant | Trans-NIH Recovery Act Research Support: Adenoviruses (Ads) are common human viruses that cause mainly respiratory infections, as well as gastrointestinal infections and severe ocular infections. Modified forms of adenovirus have shown great potential for gene delivery and vector-based vaccinati | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY | $755,600 | Grant | Trans-NIH Recovery Act Research Support: 4-1BB (CD137), a member of the TNFR superfamily, strongly influences immune cell function in many inflammatory situations. 4-1BB was originally described as a costimulatory molecule and binding to its known ligand, 4-1BBL, a member of the TNF family, is t | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $1,281,866 | Grant | Trans-NIH Recovery Act Research Support: Although the first successful human gene therapy was performed in XSCID patients, the occurrence of T cell leukemia in five of twenty successfully treated patients three to six years following treatment has shown that gene therapy is not without potential | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $728,317 | Grant | Trans-NIH Recovery Act Research Support: The Alphavirus genus in the Togaviridae family contains a number of significant human and animal pathogens that are widely distributed on all continents, excluding the Antarctic regions. Some of the alphaviruses, e.g., the Venezuelan, eastern and western | Health and Human Services, Department of / National Institutes of Health | 5/06/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $695,250 | Grant | Trans-NIH Recovery Act Research Support: Adenoviruses are small, non-enveloped viruses containing a linear double stranded DNA genome that were first discovered in 1953. The human adenoviruses are associated with a variety of diseases including upper respiratory infections, gastrointestinal illn | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $824,791 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Recognition of pathogens by the innate immune system activates TLR-mediated pathways, resulting in NF-kB induced transcription of inflammatory cytokines. These molecules subsequently direct the initiation of appropriat | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| BRANDEIS UNIVERSITY | $782,187 | Grant | Trans-NIH Recovery Act Research Support: Reaching for objects is a natural and common behavior. A great deal of behavioral and physiological effort has been devoted to understanding reaching behavior. This project is the continuation of a unique attempt to understand how humans are able to reach | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $793,500 | Grant | Trans-NIH Recovery Act Research Support: Our long term goal is to understand the role of the basonuclin gene in skin and hair follicle biology. Basonuclin (BNC1) is a zinc finger protein found in abundance in the keratinocytes of the epidermis and hair follicle. We believe that it coordinates ac | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| CALIFORNIA INSTITUTE OF TECHNOLOGY | $1,048,025 | Grant | Trans-NIH Recovery Act Research Support: This project is a continuation of a line of investigation we started more than 20 years ago. We then discovered a protein, called NF-KB, that subsequent work has shown to play a key role in inflammation and immunity. Here we propose four lines of investi | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF IOWA, THE | $737,534 | Grant | Trans-NIH Recovery Act Research Support: Insulators are elements required for transcriptional fidelity in eukaryotic genomes. Prevailing models suggest that insulators are structural components that divide chromosomes into loop domains to constrain enhancer and silencer action. The goal of our s | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $521,185 | Grant | Trans-NIH Recovery Act Research Support: To understand how the microtubule motors, cytoplasmic dynein and kinesins, find and transport cargoes to specific cellular destinations, we need to know much more about how motors are attached to cargoes. The extended morphology of axons and dendrites mak | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $367,055 | Grant | Trans-NIH Recovery Act Research Support: The bodyG??s first line of defense against infection is the circulating white blood cells that detect and respond to tissue damage. These cells move rapidly towards the site of injury using an amoeboid type of motility. This movement is characterized by | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UTAH STATE UNIVERSITY | $612,216 | Grant | Trans-NIH Recovery Act Research Support: Grant Number 2R01 GM047297 Mechanisms of Phosphoryl Transfer This project studies several enzymes involved in controlling the levels of phosphorylation of proteins in humans, a factor in many diseases. Abstract The project will utilize a multidisciplina | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF ARIZONA | $707,564 | Grant | Trans-NIH Recovery Act Research Support: Proteins play a central role in living organisms, serving, for example, as enzymes that catalyze metabolic reactions, as structural or mechanical units, and as cell signaling molecules. The field of proteomics, which entails large scale identification and | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $580,088 | Grant | Trans-NIH Recovery Act Research Support: The grant entitled ?How does a4b1 integrin regulate cell migration? proposes to investigate a novel association between the cytoplasmic tail of a4 integrin and non-muscle myosin IIA (MIIA). Two aims are proposed to study this association: (1) characterize | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $618,000 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This application is a revised proposal to assess aspects of adrenergic receptor and P2Y purinergic receptor signaling. Our recent, preliminary data for this application include the identification and cloning of five di | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $670,860 | Grant | Trans-NIH Recovery Act Research Support: Mitochondria play a pivotal role in cell survival and tissue development by virtue of their role in energy metabolism, regulation of cellular Ca2+ homeostasis and apoptosis. Given this multifactorial role, these aspects of cellular function must operate a | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CONNECTICUT | $535,500 | Grant | Trans-NIH Recovery Act Research Support: Natural Killer T (NKT) cells are potent regulatory T cells that have been shown to be intimately involved in the response to infection and tumor progression. There is also strong evidence that NKT cells may regulate the immune system in such a way as to p | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $1,165,428 | Grant | Trans-NIH Recovery Act Research Support: The immunological response to placental MHC class I expression is considered to be important, yet neither the mechanisms nor the significance of this response in humans or nonhuman primates is well understood. We have recently shown that in pregnant rhes | Health and Human Services, Department of / National Institutes of Health | 9/02/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $1,531,170 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by principal investigator): Preterm birth is a leading cause of infant mortality and morbidity in the U.S. and across the globe. Infection has consistently been identified as an important risk factor for preterm birth. A two to three | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| UNIVERSITY OF PITTSBURGH THE | $677,678 | Grant | Trans-NIH Recovery Act Research Support: Nongenomic Androgen Signaling in Sertoli Cells. The long-term goal of this project remains to determine the molecular and cellular mechanisms by which testosterone regulates spermatogenesis. Aim 1 is to determine whether non-classical signaling by testost | Health and Human Services, Department of / National Institutes of Health | 7/29/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $998,693 | Grant | Trans-NIH Recovery Act Research Support: The overall purpose of this award, entitled Defining Residues Critical to Fibrin Clot Structure - ARRA, is to determine the molecular interactions that mediate fibrin clot formation. We are continuing with this work on a six-month, no-cost extension of | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| NORTHWESTERN UNIVERSITY | $913,342 | Grant | Trans-NIH Recovery Act Research Support: Neovascularization of injured tissue is fundamental for its regeneration. Recent studies have indicated an intimate relationship between angiogenesis, vasculogenesis and the repair of injured nerves. Our preliminary data indicate that repair of injured ne | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| DUKE UNIVERSITY | $767,680 | Grant | Trans-NIH Recovery Act Research Support: The actions of the renin-angiotensin system (RAS) to control blood pressure are primarily mediated by type I (AT1) angiotensin receptors. In work done during the previous funding period using a kidney cross- transplantation model, we demonstrated distinct | Health and Human Services, Department of / National Institutes of Health | 9/10/2009 |
| UNIVERSITY OF WASHINGTON | $904,409 | Grant | Trans-NIH Recovery Act Research Support: Myocardial energetics is impaired and fatty acid oxidation decreased in failing hearts of both animal models and patients. Although it is increasingly recognized that altered cardiac energy metabolism is integral of the development and progression of hear | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $1,105,890 | Grant | Trans-NIH Recovery Act Research Support: Autophagy is manifested by degradation of cytoplasmic organelles via a lysosomal pathway, involving rearrangement of intracellular membranes to sequester damaged proteins or organelles within formed membrane vesicles, or autophagosomes. Autophagosomes the | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $764,085 | Grant | Trans-NIH Recovery Act Research Support: Notch functions to modulate cell-fate decisions during vascular development. The overall objectives are to define roles for Notch during sprouting of blood vessels and lymphatic specification and remodeling. In the first part, we explore the hypothesis th | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| MAINE MEDICAL CENTER | $819,421 | Grant | Trans-NIH Recovery Act Research Support: This award is entitled G?Regulation of Endothelial Cell Function by SproutyG?. Receptor tyrosine kinase (RTK)-initiated signaling mechanisms are major pathways critical for vascular development and angiogenesis, and mediate signals from angiogenic factor | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF WASHINGTON | $780,000 | Grant | Trans-NIH Recovery Act Research Support: Much research has been directed at understanding the cellular and molecular mechanisms responsible for the steep increase of active force with increasing length in cardiac muscle (the Frank-Starling mechanism). Our studies have lead us to believe that th | Health and Human Services, Department of / National Institutes of Health | 6/21/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $907,262 | Grant | Trans-NIH Recovery Act Research Support: Vascular gas embolism contributes to cerebral dysfunction in over 300,000 cardiopulmonary bypass patients in the US annually. Transient and permanent brain abnormalities occur. These include reduced cognitive function, speech and speech processing impairm | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $810,815 | Grant | Trans-NIH Recovery Act Research Support: This project addresses mechanisms that are responsible for formation of the ventricular chamber of the heart during mouse embryonic development. We have advanced a model in which signals secreted from the epicardium promote cell division and morphological | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $803,915 | Grant | Trans-NIH Recovery Act Research Support: Antiretroviral nucleoside analogs used in highly active antiretroviral therapy (HAART) are associated with a variety of tissue toxicities associated with mitochondrial DNA depletion, suggesting a block in mt-DNA replication. Since the triphosphate-forms o | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $908,083 | Grant | Trans-NIH Recovery Act Research Support: In the previous proposal, the central hypothesis was to determine if CRP promotes atherothrombosis by effects on both endothelial cells and monocytes. We have now executed all four aims of this proposal and have advanced the field with regards to the vasc | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $1,524,560 | Grant | Trans-NIH Recovery Act Research Support: New approaches to implement proven preventive and lifestyle interventions are needed to reach the NHLBI strategic plan goal to speed the translation of science into practice and reduce the public health burden of cardiovascular disease (CVD). The Family-C | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $773,082 | Grant | Trans-NIH Recovery Act Research Support: This project is being supported with funds from the American Recovery and Reinvestment Act, which may involve a reduction in the research aims and scope. If necessary, a revised abstract will be posted soon and this notice removed. DESCRIPTION (provided | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $809,702 | Grant | Trans-NIH Recovery Act Research Support: The sympathetic drive emanating from the brain is increased in animal models of hypertension and in patients with hypertension. The paraventricular nucleus (PVN) of the hypothalamus is an important site for the control of sympathetic outflow through its p | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF CONNECTICUT | $814,523 | Grant | Trans-NIH Recovery Act Research Support: In the prefrontal cortex, a brain area implicated in pathophysiology of schizophrenia, neurons receive numerous synaptic contacts from dopamine-rich fibers. At present, it is not clear how exactly release of dopamine affects the activity of cortical neur | Health and Human Services, Department of / National Institutes of Health | 4/27/2009 |
| MAYO CLINIC | $1,666,669 | Grant | Trans-NIH Recovery Act Research Support: This is a revised, competitive renewal application for the Genetics of Microangiopathic Brain Injury (GMBI) study, initially funded in 2001 as an ancillary study to the Genetic Epidemiology Network of Arteriopathy (GENOA) and Family Blood Pressure Program | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| WAYNE STATE UNIVERSITY (INC) | $878,802 | Grant | Trans-NIH Recovery Act Research Support: The first aim is to relate signaling intermediates in the MAPK pathway to activity-dependent gene induction and changes in synaptic organization in human epileptic neocortex. The second is to use an eplieptic model in the rat to determine the functional | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY SYSTEM OF NEW HAMPSHIRE | $217,500 | Grant | Trans-NIH Recovery Act Research Support: The development of a simple, high-yielding chain extension reaction that facilitates the preparation of heavily functionalized, amino acid-derived ?-keto esters is proposed. The utility of this method is anticipated for the preparation of ketomethylene an | Health and Human Services, Department of / National Institutes of Health | 8/15/2009 |
| UNIVERSITY OF PACIFIC | $175,391 | Grant | Trans-NIH Recovery Act Research Support: The methylotrophic yeast, Pichia pastoris, is a popular protein expression system because of its ability to produce high levels of heterologous gene products either intracellularly or extracellularly. Targetting proteins to the extracellullar medium serve | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF CHICAGO, THE | $57,255 | Grant | Trans-NIH Recovery Act Research Support: This application is in response to NOT-OD-09-060 NIDDK FY2009 Program for Administrative Supplements Utilizing Recovery Act Funds: Summer Research Experiences for Students and Science Educators. It requests support for three undergraduate students to carr | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| MISSOURI SYSTEM, UNIVERSITY OF | $260,669 | Grant | Trans-NIH Recovery Act Research Support: This overall research endeavor has the broad goal to develop placement methods for in-situ sediment remediation amendments. The parent grant is In-Situ Sediment Remediation Using Benthic Waterjet Amendment Placement (NIH# 5R01ES016158 ). The supplement sp | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $85,141 | Grant | Trans-NIH Recovery Act Research Support: This proposal is in response to the NIH and NCI announcement on the Availability of Recovery Act Funds for Administrative Supplements (NOT-OD-09-056) for the R00 phase of the Pathway to Independence Award. I believe that the studies will greatly accelerat | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $28,143 | Grant | Trans-NIH Recovery Act Research Support: The androgen receptor (AR), a ligand-dependent transcription factor, plays a key role in the onset and progression of prostate cancer and is a therapeutic target. In K99 phase we have defined the direct ARdependent target genes in both androgen-dependent | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| MIND RESEARCH NETWORK, THE | $22,692 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this summer administrative supplement was to give promising students the opportunity to gain hands-on experience in a translational study testing the role of genetics in pharmacological treatment response for alcohol dependence. To this en | Health and Human Services, Department of / National Institutes of Health | 7/10/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $165,251 | Grant | Trans-NIH Recovery Act Research Support: This revised competing renewal application continues research aimed at understanding resolution processes in problem drinkers and promoting resolution efforts in the community. The research is guided by behavioral economics, which provides a powerful fram | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $94,031 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this award is to provide funds to support research projects begun under the parent project (AA009986) and to develop new avenues of research on defining how ethanol inhibits glutamate receptor function. This work utilizes molecular biology | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| TEXAS A & M UNIVERSITY SYSTEM HEALTH SCIENCE CENTER RESEARCH | $26,233 | Grant | Trans-NIH Recovery Act Research Support: Alcohol is an important teratogen. Much research has focused on the sensitivity of the third- trimester period of brain development, where ethanol has been shown to be neuro-toxic. However, we know very little about the vulnerability of the second trimest | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) | $156,000 | Grant | Trans-NIH Recovery Act Research Support: The parent grant for this Administrative Supplement investigates the effects of ethanol on excitation-contraction (E C) coupling, using animal models and isolated cell systems. Our work to date has shown that both acute and chronic ethanol exposure suppr | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| RAND CORPORATION, THE | $255,696 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The middle school years are peak years for initiation of alcohol and marijuana (Johnston et al., 2004). Unfortunately, most youth who engage in substance use and experience problems are unlikely to voluntarily make use | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $50,500 | Grant | Trans-NIH Recovery Act Research Support: The broad, long-term objectives of this research are to elucidate the mechanisms underlying the increase in insulin sensitivity for glucose metabolism that is a hallmark and major health benefit of calorie restriction (CR; consuming 60% of ad libitum, AL, | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| BRANDEIS UNIVERSITY | $16,773 | Grant | Trans-NIH Recovery Act Research Support: Many middle-aged and older adults believe as they age that memory declines are inevitable and there is little that can be done. Such beliefs of low self-efficacy and limited control over memory aging are associated with poorer performance on a wide range | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $105,064 | Grant | Trans-NIH Recovery Act Research Support: Phosphate homeostasis is maintained primarily by a bone-kidney endocrine axis. When phosphate is in excess, fibroblast growth factor-23 (FGF23) is secreted from bone and acts on kidney to promote phosphate excretion into urine, thereby inducing negative p | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $368,869 | Grant | Trans-NIH Recovery Act Research Support: This is a request competitive revision of the parent grant R01 AG019787 in response to Notice Number (NOT-OD-09-058): NIH Announces the Availability of Recovery Act Funds for Competitive Revision. The goal of the parent application is to study mechanisms | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| CLARKSON UNIVERSITY | $154,112 | Grant | Trans-NIH Recovery Act Research Support: This project will use ARRA supplement funds to enhance the research productivity outlined by the funded NIH NIA grant 5R01-AG26553-3 (Robinson) entitled: Phase-Locked Postural Perturbation Psychophysical Models, by involving students and science teachers | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| NEW YORK UNIVERSITY (INC) | $60,782 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement award is linked to the parent grant 1R01 AG030539 entitled G?Cerebral amyloidosis and dementiaG? that proposes the study of alternative models of neurodegeneration in close comparison with AlzheimerG??s disease (AD) to ident | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| ALBANY MEDICAL COLLEGE | $27,893 | Grant | Trans-NIH Recovery Act Research Support: This application is a request for supplemental funds to support Undergraduate Summer Research related to the studies proposed in the parent application R01AG031067 entitled G?Redox Control of MMP-1 and SenescenceG?. Matrix metalloproteinase-1 (MMP-1) o | Health and Human Services, Department of / National Institutes of Health | 8/08/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $581,127 | Grant | Trans-NIH Recovery Act Research Support: Specific aims of the supplement: Specific Aim 1: To enhance the activities of the CITAD clinical trial by increasing the tempo of participant recruitment by providing $10,000 for two years in direct costs to all study sites. This will result in an earlier | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| UNIVERSITY OF MARYLAND | $705,517 | Grant | Trans-NIH Recovery Act Research Support: Hot flushes pose a significant public health concern world-wide. These perimenopausal symptoms are the primary reason that women seek medical care during the menopausal transition. Hot flushes often negatively impact the quality of life of women because t | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $187,428 | Grant | Trans-NIH Recovery Act Research Support: This is an application in response to notice NOT-OD-09-056, requesting a supplement to grant 5R01AG031722-32, which focuses on the role of epigenetic mechanisms in A-betas effects on plasticity and memory formation. This supplement application requests s | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| OREGON STATE UNIVERSITY | $36,000 | Grant | Trans-NIH Recovery Act Research Support: This revised proposal seeks support for an investigator-initiated research project into the cellular and molecular means used by intermediate hosts of a human parasite to immunologically attack and kill these parasites. The broad, long-term objective is t | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| THE WASHINGTON UNIVERSITY | $37,401 | Grant | Trans-NIH Recovery Act Research Support: The purpose of our research is to explain antigen presentation by class II MHC molecules having a strong biochemical, quantitative and mechanistic foundation in order to avoid the many empiricisms that dominate this complex area. We investigated how the m | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| BAYLOR COLLEGE OF MEDICINE | $34,256 | Grant | Trans-NIH Recovery Act Research Support: The purpose was to stimulate progress on the paretnt grant and create/retain reserch positions for undergraduate students. The objective of the parent application is to determine the essential pathways that drive T cell independent B cell activation and I | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $208,387 | Grant | Trans-NIH Recovery Act Research Support: Although the brain is an immune privileged site, adaptive immunity can provide resistance to various infectious diseases that affect the CMS. This is illustrated by the important role that T cells play in resistance to Toxoplasmic encephalitis (TE) which | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON | $35,720 | Grant | Trans-NIH Recovery Act Research Support: Alzheimer's Disease (AD) is an age-associated dementia for which there is currently no cure. AD is characterized by memory deficits, loss of CNS neurons, and eventually death. One of the prominent events in AD is the CNS presence of plaques that are mostl | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF CHICAGO, THE | $316,278 | Grant | Trans-NIH Recovery Act Research Support: The major focus of the original grant was on the molecular mechanisms within CD43 that regulates T cell trafficking. Each aim in the original approved application proposed to define the role of CD43 and interacting molecular partners on T cell traffickin | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $147,589 | Grant | Trans-NIH Recovery Act Research Support: This supplement will streamline our laboratory protein production and protein analysis pipelines that are currently impeding scientific progress on our parent grant: AI43700-08 entitled Structure Studies on Proteins that Modulate IL-10 Action. The centra | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF WASHINGTON | $330,956 | Grant | Trans-NIH Recovery Act Research Support: In 2007, our group was awarded a 5 year continuation(2007-2012) of ourR01, entiteld ' The role of cellular factors in the HIV-1 capsid assemblypathway'. Key goals in this R01 were to: Identify novel cellular factorsin the 80S/150S assembly intermediate | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $291,191 | Grant | Trans-NIH Recovery Act Research Support: Studies will investigate capabilities and mechanisms whereby eosinophils, including those recruited within airways in asthma, function as antigen-presenting cells that are of importance in propagating or modulating varied lymphocyte-dependent responses to | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $11,154 | Grant | Trans-NIH Recovery Act Research Support: We will investigate whether IgE levels regulate mast cell numbers in the intestine during a response to food allergens. This work has been completed by Natalia Diaz who was hired under this award as a summer student and has now left the lab. | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF CALIFORNIA, SANTA CRUZ | $34,809 | Grant | Trans-NIH Recovery Act Research Support: Vibrio cholerae causes the disease cholera and is a natural inhabitant of aquatic environments. Seasonal cholera outbreaks occur where the disease is endemic and can spread worldwide. V. cholerae's ability to cause epidemics is tied to its ability to surv | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $6,948 | Grant | Trans-NIH Recovery Act Research Support: The rational design of a curative therapy must entail targeting the suppression of pathogenic Th2 cells. Given that both IFN-a and IFN-B are routinely used to treat hepatitis C and multiple sclerosis, our novel studies will lay the groundwork towards tes | Health and Human Services, Department of / National Institutes of Health | 6/15/2009 |
| NEW YORK UNIVERSITY (INC) | $70,416 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The lentivirus virion infectivity factor (Vif) is an accessory protein that is required for productive replications of the virus in primary cells and some, but not all, transformed T cell lines. HIV-1 that is genetic | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| NATIONAL JEWISH HEALTH | $332,895 | Grant | Trans-NIH Recovery Act Research Support: The innate immune system provides acute defense against infectious agents and environment toxicants. At the core of this defense system are sensory molecules or receptors that are expressed by most cells of the organism. The existence of these sensors and | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $263,513 | Grant | Trans-NIH Recovery Act Research Support: We are requesting additional funding to maintain productivity on this project. The funding will be used for maintaining the employment of existing members of my laboratory, covering additional costs associated with reagents, biochemicals, mouse housing, a | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF PITTSBURGH THE | $157,775 | Grant | Trans-NIH Recovery Act Research Support: The parent grant was funded for studies on the effects of TIM-1 ligation on T cell activation. This includes determination of the effects of TIM-1 ligands and specific antibodies on T cell cytokine production and effector development, and detailed analysi | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE | $99,450 | Grant | Trans-NIH Recovery Act Research Support: Purchase of an Axio Observer Z1 Motorized Inverted Research Microscope equipped for live cell imaging and image deconvolution from Carl Zeiss Microimaging of New England. The overall goal of the parent project is to identify and characterize Entamoeba h | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| THE GEORGE WASHINGTON UNIVERSITY | $19,131 | Grant | Trans-NIH Recovery Act Research Support: The aims of the parent project include the development of replication incompetent Moloney Murine Leukemia Virus (MMLV) vectors pseudotyped with vesicular stomatitis virus glycoprotein (VSVG) and investigation of the vectors for transduction of development | Health and Human Services, Department of / National Institutes of Health | 6/17/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $42,180 | Grant | Trans-NIH Recovery Act Research Support: Leishmaniasis is a serious disease associated with a wide range of clinical manifestations caused by intracellular protozoan parasites belonging to the Genus Leishmania. While the host immune response is important in the outcome of infection, different Le | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $113,330 | Grant | Trans-NIH Recovery Act Research Support: Modified Triterpines as Potent HIV Fusion Inhibitors Prior studies on the natural triterpene betulinic acid (1) led to our discovery and development of Bevirimat (2), a modified triterpene and the first-in-class HIV maturation inhibitor. In these studie | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $282,787 | Grant | Trans-NIH Recovery Act Research Support: Chronic Viral infections represent a major health problem and have been associated with deficient CD8 T cells responses. We recently found that attenuation of TGF?+? signaling during chronic Lymphocytic choriomeningitis virus infection results in increase | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| MAYO CLINIC | $180,389 | Grant | Trans-NIH Recovery Act Research Support: One of the two central hypotheses of the parent grant (R01 AR27065) was that bone strength estimates by finite element (FE) analyses, which can now be obtained from clinical quantitative computed tomography (QCT) images, will enhance the ability to identi | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $35,670 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to determine the role of actomyosin structural dynamics in the molecular mechanism of force generation in muscle. Emphasis is placed on the use of high-resolution and time- resolved (TR) spectroscopy to test and revise detailed | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $283,133 | Grant | Trans-NIH Recovery Act Research Support: This supplement to NIAMS grant R01AR041135 provided funds to identify genetic modifiers of Loeys-Dietz syndrome using mouse models. This funding will support personnel, reagent and service costs. | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $209,477 | Grant | Trans-NIH Recovery Act Research Support: The long-term objective of our research program is to understand transcriptional control of epidermal development and differentiation within the epidermis. One critical function of the epidermis is to form an effective permeability barrier; defective epid | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF ROCHESTER | $73,615 | Grant | Trans-NIH Recovery Act Research Support: Myotonic dystrophy type 1 [DM1] leads to maldevelopment, myotonia, and wasting of skeletal muscle. DM1 is caused by an unstable CTG repeat expansion in the 3' untranslated region of DMPK. Our central hypothesis is that skeletal muscle findings in DM1 resu | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| MAYO CLINIC | $406,331 | Grant | Trans-NIH Recovery Act Research Support: The proposed studies address very basic questions about the postnatal growth of phrenic motoneurons and diaphragm muscle (DIAm) fibers. Such growth of phrenic motoneurons and DIAm fibers is necessary to meet the increasing functional diversity of the DIAm | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF IOWA, THE | $488,985 | Grant | Trans-NIH Recovery Act Research Support: The parent project long-term goal is to explore the therapeutic potential of up-regulating 5-sarcoglycan levels for the treatment of limb-girdle muscular dystrophy type 2D (LGMD2D). Mutations in the 1-sarcoglycan gene cause LGMD2D, and leads to progressiv | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $35,564 | Grant | Trans-NIH Recovery Act Research Support: With the discovery that mutations in fourteen different keratin genes can cause eight distinct epithelial fragility disorders, comes the realization that the keratin filament cytoskeleton is crucial to the structural integrity of epithelial tissues expose | Health and Human Services, Department of / National Institutes of Health | 6/10/2009 |
| CORNELL UNIVERSITY, INC | $81,312 | Grant | Trans-NIH Recovery Act Research Support: We are interested in elucidating the molecular mechanisms involved in tissue stem cell self-renewal and fate choice, in normal tissue development and homeostasis. Stem cells hold great promises for future therapies of numerous deadly diseases, yet their b | Health and Human Services, Department of / National Institutes of Health | 6/10/2009 |
| NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC. | $119,970 | Grant | Trans-NIH Recovery Act Research Support: The goal of this proposed administrative supplement grant is to determine risk factors for tumor recurrence after treatment of nonmelanoma skin cancer (NMSC). In particular, data from the NIMSC Cohort Study (funded by the parent grant) will be used to con | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $231,132 | Grant | Trans-NIH Recovery Act Research Support: In the skeletally mature individual, hyaline articular cartilage does not heal effectively when injured and the natural progression of acquired articular cartilage defects is predictably poor, commonly culminating in joint arthrosis. Physician and patient | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF PITTSBURGH THE | $610,272 | Grant | Trans-NIH Recovery Act Research Support: Paget's disease (PD) is the second most common bone disease and affects 1-2 million patients in the U.S. This competitive revision will test the hypothesis that both an environmental factor [measles virus nucleocapsid protein (MVNP)] and a genetic factor | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $418,301 | Grant | Trans-NIH Recovery Act Research Support: This project seeks to expand the scope of a project that is directed at understanding the role of nuclear Abl tyrosine kinase in DNA damage-induced cell death response. DNA damage inducers, i.e., genotoxins, are some of the most effective agents in cancer | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| THE VANDERBILT UNIVERSITY | $332,016 | Grant | Trans-NIH Recovery Act Research Support: EGF receptor (EGFR) ligands are produced as type 1 transmembrane proteins that are cleaved from the cell surface to produce soluble ligand. EGFR activation can be achieved by soluble ligand (autocrine or paracrine) or by membrane-tethered ligand (juxtacri | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $130,683 | Grant | Trans-NIH Recovery Act Research Support: NF-?B transcription factors play a key role in the proliferation and survival of many human cancers, especially ones of B-lymphoid cell origin such as HodgkinG??s lymphoma and diffuse large B-cell lymphoma (DLBCL). The primary goal of the parent grant is | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| BAYLOR COLLEGE OF MEDICINE INC | $52,949 | Grant | Trans-NIH Recovery Act Research Support: The goals of this supplement are to increase our productivity and reduce environmental waste. This application is a request for an administrative supplement from the American Recovery and Reinvestment Act of 2009 for our parent grant, CA60651, G?Mouse Mod | Health and Human Services, Department of / National Institutes of Health | 9/02/2009 |
| THE VANDERBILT UNIVERSITY | $269,700 | Grant | Trans-NIH Recovery Act Research Support: The goal of this supplement is to accelerate the work originally proposed as part of Specific Aim 3 of the award entitled G?p63 Signaling in Epithelial Cell Growth and CancerG?, which focuses on analysis of ?Np63?-associated proteins to identify proteins | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF MIAMI | $142,992 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to carry out a set of definitive experiments on key novel concepts emanating from the original application currently under a non-cost extension and at the same time consolidating the team presently working in the project. Data | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $697,656 | Grant | Trans-NIH Recovery Act Research Support: Retroviruses interact intimately with their hosts, usurping cellular pathways to complete their life cycles. Identification of novel host factors that contribute to virus replication will enhance our understanding of retrovirus-cell interactions and may p | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| OREGON RESEARCH INSTITUTE | $148,642 | Grant | Trans-NIH Recovery Act Research Support: We learned that the tobacco prevention intervention that we developed and experimentally evaluated in 48 Oregon high schools made a significant impact on adolescent smoking, alcohol and marijuana use, and depression. At the same time, we have evidence t | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| BAYLOR COLLEGE OF MEDICINE | $191,800 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this research is to identify a novel signaling pathway down stream of epithelial basolateral junctions that suppresses invasion and metastasis. | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| CALIFORNIA INSTITUTE OF TECHNOLOGY | $387,114 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement request is (1) for funds to purchase a new bench top flow cytometric analyzer with the ability to detect seven colors of fluorescence from three lasers, and (2) to take advantage of a greatly superior technical approach to | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE | $166,000 | Grant | Trans-NIH Recovery Act Research Support: Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy, with a five-year survival rate approaching 80%. We have shown highly significant differences in survival among ethnic and racial groups. The remission rates were comparable among | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $999,563 | Grant | Trans-NIH Recovery Act Research Support: Bleeding and thrombotic disorders are characterized by significant phenotypic variability. Over the last decade important advances have been made in the understanding of the molecular basis of these disorders; however a large portion of the observed varia | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $999,999 | Grant | Trans-NIH Recovery Act Research Support: This application addresses the Challenge Area 06 of 'Enabling Technologies and Prevention' and the specific Challenge Topic 06-HL-104 of 'enabling technologies involving the development of nanotools for pulmonary medicine, particularly aimed at safer and | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| MONTEFIORE MEDICAL CENTER | $709,755 | Grant | Trans-NIH Recovery Act Research Support: This application addresses Challenge Topic 03-HL-101* to identify and validate clinically relevant, quantifiable biomarkers of diagnostic and therapeutic responses for blood and vascular dysfunction - specifically, the antiphospholipid syndrome (APS) an a | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $967,223 | Grant | Trans-NIH Recovery Act Research Support: Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice, affecting more than 2 million individuals in the US, with growing prevalence as the population ages. Moreover, AF is associated with a higher incidence of stroke, heart | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $999,999 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This application addresses the broad Challenge Area (03) Biomarker Discovery and Validation and the specific Challenge Topic, 03-HL-101: Identify and validate clinically relevant, quantifiable biomarkers of diagnostic | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF PITTSBURGH THE | $999,818 | Grant | Trans-NIH Recovery Act Research Support: This proposal addresses Challenge area 7: Enhancing Clinical Trials: 07-OD(ORDR)-102 for the development of a rare disease genetic patient registry. Peripartum cardiomyopathy (PPCM) is a complication of pregnancy occurring in 1:1800 to 1:3500 births in th | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $979,923 | Grant | Trans-NIH Recovery Act Research Support: This project will mine text from Internet discussion boards, chat rooms, and blogs to identify possible side effects and adverse4 events associated with the use of herbal supplements in breast and prostate cancer. We will identify sites that support thes | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $802,169 | Grant | Trans-NIH Recovery Act Research Support: The title of this project is Improving Childhood Immunization Compliance Using Electronic Health Records. This application addresses broad Challenge Area (05) Comparative Effectiveness Research and specific Challenge Topic, 05-LM-103: Improving Compliance | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $644,959 | Grant | Trans-NIH Recovery Act Research Support: Does Enhanced School-Readiness Affect Adult Health of African Americans? The purpose of the study entitled Does Enhanced School-Readiness Affect Adult Health of African Americans was to learn if participants in a randomized trial of early childhood educat | Health and Human Services, Department of / National Institutes of Health | 9/20/2009 |
| WAYNE STATE UNIVERSITY (INC) | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: Primary care practice-based research networks (PBRNs) often report high participation rates in their studies. The NIH recognizes PBRNs as important vehicles for translational research projects, strongly supporting them through Clinical and Translational S | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $974,549 | Grant | Trans-NIH Recovery Act Research Support: Recovery Act Limited Competition: NIH Challenge Grants in Health and Science Research (RC1) RFA-OD-09-003 Broad Challenge Area: 15, Translational Science Research Area: 15-MH-109 Prefrontal cortex regulation of higher brain function and complex behaviors. | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | $993,675 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this proposal is to advance the development of behavioral and genetic biomarkers for autism and related disorders. While it is clear that autism has a strong inherited genetic component, very large scale genetic studies that have relie | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $999,996 | Grant | Trans-NIH Recovery Act Research Support: This proposal addresses broad Challenge Area (15) Translational Science, and specific challenge topic 15-MH-109 Prefrontal cortex regulation of higher brain function and complex behaviors. Nearly all psychiatric disorders, from schizophrenia to depression | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF PITTSBURGH THE | $911,922 | Grant | Trans-NIH Recovery Act Research Support: A controversial component of the Medicare Prescription Drug Benefit (Part D) enacted in 2006 is the doughnut hole, a gap in coverage for pharmacy expenditures between $2,250 and $5,100. We recently reported that one in four seniors entered the doughnut ho | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: This application is in response to NIMH Challenge Area (08) Genomics, Challenge Topic 08-MH-102, Schizophrenia Interactome. Schizophrenia is a devastating mental illness affecting millions in the US and worldwide, with profound human and economic costs. | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF PITTSBURGH THE | $985,762 | Grant | Trans-NIH Recovery Act Research Support: Psychiatric Disorders such as alcohol/substance abuse disorders, depression, bipolar disorder and impulsivity-related disorders such as ADHD are among the most significant causes of illness and death in the USA (together affect at least 17 percent of the | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REACH INSTITUTE | $395,783 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area 15-MH-105, Strategies to support uptake of interventions within clinical and community settings: Develop and pilot comprehensive implementation strategies to support the broader uptake of interventions withi | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| WESTERN INTERSTATE COMMISSION FOR HIGHER EDUCATION | $988,937 | Grant | Trans-NIH Recovery Act Research Support: Most college stuents with mental disorders do not receive treatment, and over 80% of those who die by suicide have never made contact with campus mental health services. Knowledge, stigma, and other health beliefs represent significant barriers to help-se | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| CHILDRENS HOSPITAL OF PHILADELPHIA | $949,431 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (15) Translational Science, Gene x environment x development (GxExD) studies of brain function & mental disorders. Gene x environment epidemiology & psychiatry research studies have only recently been used & | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $845,947 | Grant | Trans-NIH Recovery Act Research Support: We propose to undertake an empirical investigation of the predictive validity of CBC in the clinical context of racial ethnic disparities in analgesic preference and adherence to prescription analgesia for cancer pain. Data derived from this study will la | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | $834,860 | Grant | Trans-NIH Recovery Act Research Support: his application addresses broad Challenge Area (02): Bioethics and specific Challenge Topic 02- OD(OSP)-101: Unique Ethical Issues Posed by Emerging Technologies. The current study examines the ethical challenges inherent in participants' considerations o | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $823,694 | Grant | Trans-NIH Recovery Act Research Support: This application is designed to identify compounds to treat Charcot-Marie-Tooth type 2E (CMT2E). CMT is the most commonly inherited neurological disorder with a reported prevalence of 1 in 2,500 people worldwide. It is found in all races and ethnic groups | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| TRUSTEES OF PRINCETON UNIVERSITY, THE | $992,745 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (06) Enabling Technologies, 06-NS-106: Validating new methods to study brain connectivity. We propose to test a new method that provides substantial improvement over previous Cre-conditional viral tracers. T | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF FLORIDA | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: This application addresses Broad Challenge Area (04) Clinical Research, and specific Challenge Topics, 04-NS-103 Developing consortia for clinical research, and is also, in part, relevant to 07-OD(ORDR)-102* Rare disease genetic patient registry. The Univ | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF UTAH, THE | $994,700 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This application addresses broad challenge area 05 Comparative Effectiveness Research and specific challenge topic 05-NS-101 Consortia Building for Comparative Effectiveness Research in Clinical Neuroscience. The long- | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $803,688 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (06) Enabling Technologies, and specific Challenge Topic, 06-NS-106: Validating new methods to study brain connectivity. Mapping the structure and function of neural circuits is an important prerequisite to | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF UTAH, THE | $980,750 | Grant | Trans-NIH Recovery Act Research Support: This application addresses the broad Challenge Area (05) Comparative Effectiveness Research and specific Challenge Topic, 05-GM-101: Anesthesiology Clinical Pharmacology Sepsis Trauma, Burn, and Peri-operative Injury Wound Healing. Traumatic brain injury | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (06): Enabling Technologies, and specific Challenge Topic, 01-OD-101: Development of new tools and technologies to interrogate human mitochondrial function in vivo. Dysfunction of Mitochondria (MT) dysfun | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF PITTSBURGH THE | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: This project addresses broad Challenge Area: Enabling Technologies, Challenge Topic 06-HD-101, Improved Interfaces for Prostheses to Impact Rehabilitation Outcomes. Recent advances in decoding motor intentions and the technology to record populations o | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON | $951,766 | Grant | Trans-NIH Recovery Act Research Support: Challenge Area and Specific Challenge Topic: This application addresses broad Challenge Area (10) Information Technology for Processing Health Care Data and specific Challenge Topic, 10-RR-101*: Information Technology Demonstration Projects Facilitating S | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $1,742,866 | Grant | Trans-NIH Recovery Act Research Support: Alcohol and nicotine are the most commonly abused legal drugs in the United States. There is a high incidence of nicotine dependence in alcoholdependent individuals, and there is also high rate of problem drinking in habitual smokers. There is considerabl | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| RUSH UNIVERSITY MEDICAL CENTER | $1,974,161 | Grant | Trans-NIH Recovery Act Research Support: Molecular Markers of Alcohol Exposure and Alcohol-induced Tissue Injury: Alcohol causes tissue injury and organ dysfunction by disrupting the homeostatis interaction between the intestinal microbiome and the human homobiome. The goal is to identify mol | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $1,828,862 | Grant | Trans-NIH Recovery Act Research Support: Estimates of death rates caused by chronic alcohol consumption, published in 2004 by the World Health Organization, indicate that alcohol accounts for approximately 1.8 million deaths per year. Alcohol consumption leads to addiction and damage to almost e | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| NORTHWESTERN UNIVERSITY | $929,525 | Grant | Trans-NIH Recovery Act Research Support: GENORM will capitalize on and extend the NIH Toolbox for the Assessment of Neurological and Behavioral Function (a Blueprint for Neuroscience Research Initiative), by adding the collection and storage of DNA to the planned and already-funded Toolbox norm | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| OHIO STATE UNIVERSITY, THE | $1,335,019 | Grant | Trans-NIH Recovery Act Research Support: This proposal is responsive to the Area of Scientific Priority Development of tools to facilitate research on the basic biology of aging of the National Institute on Aging. Accurate, fast and unbiased methods to detect rare cells in cell suspensions for r | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $5,404,364 | Grant | Trans-NIH Recovery Act Research Support: The proposed IT infrastructure will provide a state of the art platform on which to build, test, and deploy large scale behavioral intervention studies and advance the science at the intersection of behavioral economics and health. We will provide linkage | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| SUTTER WEST BAY HOSPITALS | $855,594 | Grant | Trans-NIH Recovery Act Research Support: Overall Purpose. Loss of mobility characterized by slowing gait speed, exertional fatigue and exhaustion is a hallmark of age-related functional decline. Current studies have not explained the biological reason for this slowing and loss of mobility. In pa | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF WASHINGTON | $1,474,777 | Grant | Trans-NIH Recovery Act Research Support: This proposal represents a new interdisciplinary initiative to further develop our unique in vivo spectroscopy tools to measure mitochondrial function in vivo and to increase access to these tools for the scientific community. Mitochondria are now widely | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $900,235 | Grant | Trans-NIH Recovery Act Research Support: The broad aim of this Grand Opportunity Grant is to understand how race-based social stress, racial/ethnic (R/E) identity, and biological functioning contribute to health and healthy aging. Using the Maryland Adolescent Development in Context Study (MADIC | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $4,225,693 | Grant | Trans-NIH Recovery Act Research Support: In the last several years, a sense of urgency and a renewed interest in the study of radionuclide chemistry and biology have emerged, as threats of nuclear terrorism have become more plausible, and the risk of environmental contamination and human exposur | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| OHIO STATE UNIVERSITY, THE | $4,430,735 | Grant | Trans-NIH Recovery Act Research Support: Osteoarthritis (OA) is the most common cause of arthritis. Approximately 21 million Americans have physician-diagnosed OA and many more have undiagnosed disease. Knee OA is responsible for as much chronic disability in the elderly as cardiovascular diseas | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF PITTSBURGH THE | $2,707,443 | Grant | Trans-NIH Recovery Act Research Support: A recent Agency for Healthcare Research and Quality (AHRQ) executive summary indicated that better systems are needed to determine the relative merits of existing versus new and expensive biologic drug therapies for rheumatoid arthritis (RA). Research tha | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| TRANSLATIONAL GENOMICS RESEARCH INSTITITUE, THE | $4,269,212 | Grant | Trans-NIH Recovery Act Research Support: Despite decades of research, a limiting obstacle to personalizing oncology is identifying correlates of response against a diverse genetic background. For individuals with rare subtypes of human cancers where minimal data exists, this problem is compounde | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| CALIFORNIA INSTITUTE OF TECHNOLOGY | $1,551,274 | Grant | Trans-NIH Recovery Act Research Support: This project is to use high-throughput genomic sequencing analysis of histone marks and transcription factor binding sites to track the succession of regulatory changes that underlie multipotent progenitor differentiation into T lymphocytes. The project | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $1,551,541 | Grant | Trans-NIH Recovery Act Research Support: Our goal is to build an infrastructure to discover novel viruses associated with human cancer from next-generation sequencing data, using a sequence-based computational subtraction approach that we developed. This proposed project responds to the ARRA Res | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| KAISER FOUNDATION HOSPITALS | $3,991,808 | Grant | Trans-NIH Recovery Act Research Support: We will study several genetic tests related to colon cancer that may help doctors understand who will get colon cancer and what therapies some patients should receive. We will study who gets tested, how the genetic test result helps people decide what to | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $1,657,876 | Grant | Trans-NIH Recovery Act Research Support: ARRA - Nanotechnology enabled desktop image-guided microbeam radiation therapy system Today, state-of-the-art radiotherapy provides excellent benefits for patients with early stage and radiosensitive cancers. However, these benefits diminish for patients | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| COLD SPRING HARBOR LABORATORY | $4,737,965 | Grant | Trans-NIH Recovery Act Research Support: The goal of this Molecular Target Discovery and Development Center (MTDDC) application is to further develop the innovative functional genomic approaches we have developed at Cold Spring Harbor Laboratory (CSHL) in order to provide biological context and | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF NEW MEXICO | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: Evaluation of a CCR5 Vaccine for HIV Infection in the SIV/Macaque Model. HIV vaccine development has been complicated by the extensive antigenic variation displayed by HIV. As an alternative to targeting the virus, we have developed vaccines targeting CCR | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| OREGON RESEARCH INSTITUTE | $1,583,947 | Grant | Trans-NIH Recovery Act Research Support: This research project will identify biological markers that predict whether adolescents and young adults may become dependent on nicotine when dealing with stressful life events. Ultimately, the results of this project may explain success or failure in ou | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| DUKE UNIVERSITY | $2,187,874 | Grant | Trans-NIH Recovery Act Research Support: Psychostimulant (methamphetamine [METH] and cocaine) abuse has reached an epidemic proportion in the US and worldwide, presenting profound socioeconomic, legal and medical problems. In addition, it is a significant comorbid factor for other psychiatric di | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $2,118,383 | Grant | Trans-NIH Recovery Act Research Support: Debilitating craniofacial skeletal defects, which occur frequently as a result of congenital disorders, trauma, cancer, and surgical interventions, are some of the most challenging problems for reconstruction. While infants demonstrate the ability to heal | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF ROCHESTER | $1,528,307 | Grant | Trans-NIH Recovery Act Research Support: Virtually all US inhabitants carry detectable levels of bisphenol-A (BPA) in their tissues. Its estrogenic properties have been recognized for decades. Although BPA had been viewed as weakly estrogenic in the past, it is now likely that exposure to low do | Health and Human Services, Department of / National Institutes of Health | 9/27/2009 |
| UNIVERSITY OF MONTANA SYSTEM | $895,584 | Grant | Trans-NIH Recovery Act Research Support: The broad goals of this project are to describe the mechanism of action of toxic nanomaterials (nanowires by definition have fibrous shape similar to asbestos) both in vitro and in vivo and develop a translational model that can be used for improved testi | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF ROCHESTER | $1,146,030 | Grant | Trans-NIH Recovery Act Research Support: This study is a large-scale basic research project designed to fundamentally enhance our knowledge of how bisphenol A (BPA) affects the developing immune system and susceptibility to disease later in life. The objective of this project is to provide t | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $1,906,255 | Grant | Trans-NIH Recovery Act Research Support: Developmental reprogramming is an important mechanism by which early life exposures to environmental agents increase susceptibility to adult disease. For xenoestrogens such as BPA, additional research is required to understand how specific estrogen recept | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $1,791,020 | Grant | Trans-NIH Recovery Act Research Support: Imaging is one of the most powerful tools available to the modern biologist and recent advances in quantitative microscopy and image analysis have greatly accelerated our understanding of many complex and dynamic processes in basic biological and biomedi | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $1,970,678 | Grant | Trans-NIH Recovery Act Research Support: The mitochondrion is the center stage for energy metabolism, apoptosis, signaling, and ion homeostasis. Much of what we know about this organelle comes from studying mitochondrial respiratory chain disease (RCD). This devastating disease is due to genetic | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| BROAD INSTITUTE, INC., THE | $1,935,976 | Grant | Trans-NIH Recovery Act Research Support: The Connectivity Map 100k project aims to forge a path toward a comprehensive 'functional look-up table' that that links disease biology, genome function and small-molecule action. Such a Connectivity Map would enable researchers worldwide to generate tes | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| THE GEORGE WASHINGTON UNIVERSITY | $646,348 | Grant | Trans-NIH Recovery Act Research Support: Specific Aims within the requested 24-months of funding: (1) the role and significance of MTA1 in DNA damage response and mechanistic basis of MTA1 regulation of p53 levels; and (2) The molecular basis and significance of MTA1 upregulation of p21Waf1 in D | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| THE VANDERBILT UNIVERSITY | $9,579 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement seeks funds to support one undergraduate studentG??s summer research experience. The primary purpose is to introduce an undergraduate student to molecular cancer biology research. The student will be trained in molecular a | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $31,030 | Grant | Trans-NIH Recovery Act Research Support: An Administrative Supplement is requested for NCI grant R01-CA103146 Chemistry and Biology of Deoxyribose Oxidation. This and several other NIH grants involve quantification of molecular damage products using sensitive chromatography-coupled mass spectro | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH | $30,450 | Grant | Trans-NIH Recovery Act Research Support: This grant provided a summer research experience for one science educator in health-related scientific research for Parkinson's disease. | Health and Human Services, Department of / National Institutes of Health | 6/19/2009 |
| VIRGINIA COMMONWEALTH UNIVERSITY | $612,385 | Grant | Trans-NIH Recovery Act Research Support: The rationale and methods for the parent study are as follows: The vast majority of persons with substance use disorders go undetected and untreated. Proactive screening, brief intervention, and referral for treatment approaches (SBIRT) have tremendous po | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| WAYNE STATE UNIVERSITY (INC) | $161,500 | Grant | Trans-NIH Recovery Act Research Support: We will determine the neurotransmitter critera of presence and synthesis by identifying dopamine located in hair cells and/or efferents and localize its enzymes of synthesis in rat inner-ear sensory epithelia. We will also identify and coimmunolocalize do | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF NEBRASKA | $98,000 | Grant | Trans-NIH Recovery Act Research Support: The primary objective of this application is to identify essential oromotor skills that children obtain during early speech development and factors that contribute to individual variation in the course of speech development. The specific aims are (1) to i | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $210,692 | Grant | Trans-NIH Recovery Act Research Support: Our long-term objective is to unravel the molecular genetics of hereditary human blinding diseases, such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD). Genetic defects that lead to photoreceptor cell death in AMD and RP are highl | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $281,462 | Grant | Trans-NIH Recovery Act Research Support: Based on our studies we developed the following hypothesis: In the eye, adenosine forms an intrinsic regulatory system that is essential for maintaining lOP within normal limits. Disruption of this system leads to elevated lOP, increasing the risk for opt | Health and Human Services, Department of / National Institutes of Health | 8/19/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $15,700 | Grant | Trans-NIH Recovery Act Research Support: EGR receptor signaling is a key element in triggering specific cell fate decisions in developing eyes. But many of the downstream events and their finetuning in specific cell types is still poorly understood. The dAcn protein may play a critical role in | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| WASHINGTON UNIVERSITY, THE | $215,895 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this supplement is to accelerate our ability to understand how the brain uses visual information to generate reaching movements. Reaching towards visual targets is critical for normal daily function, and is a good model system for mor | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $345,152 | Grant | Trans-NIH Recovery Act Research Support: Alzheimer's disease (AD) is the most common form of neurodegeneration however, adequate therapies do not exist to prevent or treat AD. Since 1999, Abeta immunotherapy has been shown to lower cerebral Abeta levels and improve cognition in AD mouse models. | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| BROWN UNIVERSITY IN PROVIDENCE IN STATE OF RI AND PROVIDENCE PLANTATIONS | $352,395 | Grant | Trans-NIH Recovery Act Research Support: The long term objective of this grant proposal is to understand how the ribosome functions at the atomic level during protein synthesis. Our approach includes developing genetic and biochemical systems in the extreme thermophile Thermus thermophilus to co | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $77,288 | Grant | Trans-NIH Recovery Act Research Support: Polyamines are ubiquitous cellular components that play many roles in cellular physiology and in normal and neoplastic growth. There is good evidence that the polyamine biosynthetic pathway is a valid target for drug design. The planned experiments focus | Health and Human Services, Department of / National Institutes of Health | 9/08/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $284,941 | Grant | Trans-NIH Recovery Act Research Support: Use Solexa sequencing methods to analyze stepwise formation of genome changes. We believe we can detect rare mutants in the population whose sequence is being determined. This should reveal new mutations even if they are unstable as predicted for tandem | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $105,293 | Grant | Trans-NIH Recovery Act Research Support: This proposal is in response to Notice Number NOT-OD-09-058: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications. The parent proposal sponsors the study of the structure and mechanism of the oxygen-bridged diiron clu | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF FLORIDA | $183,017 | Grant | Trans-NIH Recovery Act Research Support: Clinical studies have demonstrated that the transfusion of packed red blood cells is independently associated with an increase in infectious complications, as well as mortality. Basic investigation into the cause of this phenomenon is limited and the eff | Health and Human Services, Department of / National Institutes of Health | 9/08/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $77,685 | Grant | Trans-NIH Recovery Act Research Support: Adhesion and migration are fundamental cell processes that are disrupted in disease states:in some cases, these disruptions cause or exacerbate the disease. Research has shown that there are many pathways and proteins involved in regulating adhesion and m | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF UTAH, THE | $166,917 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Specific gene expression is controlled by transcription factors binding to elements present in promoters and enhancers. In many instances multiple transcription factors can recognize the same DNA sequence, but each fac | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF MIAMI | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: This project will develop new statistical approaches for analysis of next-generation sequence data which is currently being generated to study genetic variation underlying important human disease traits. Our approaches will improve statistical techniques | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CHICAGO, THE | $1,800,000 | Grant | Trans-NIH Recovery Act Research Support: We propose to use bacterial artificial chromosome (BAC) recombineering to epitope tag 40 transcription factors per year for chromatin immunoprecipitation (ChIP) followed by sequencing to map binding sites genome wide. A major hurdle for the ENCODE project | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $1,191,405 | Grant | Trans-NIH Recovery Act Research Support: Children are involuntarily exposed to tobacco both in utero through maternal smoking and during childhood from secondhand smoke (SHS). SHS exposure is associated with important health problems such as low birth- weight, asthma induction, asthma exacerbati | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| OKLAHOMA MEDICAL RESEARCH FOUNDATION | $2,000,000 | Grant | Trans-NIH Recovery Act Research Support: Sarcoidosis is a multiorgan granulomatus inflammatory disorder likely resulting from an exaggerated T-dell response in genetically susceptible individuals. African-Americans are more frequently and severely affected by Sarcoidosis yet few collections of A | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| NATIONAL JEWISH HEALTH | $9,746,871 | Grant | Trans-NIH Recovery Act Research Support: Chronic lung diseases represent a broad spectrum of chronic fibrosing/inflammatory lung conditions that are for the most part poorly responsive to treatment and often fatal. COPD/emphysema is the fourth leading cause of death in the United States and the | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $2,696,700 | Grant | Trans-NIH Recovery Act Research Support: We are creating stem cells from human skin cells (we call these stem cellsinduced pluripotential stem cells or iPSCs). Thus, we are able to make stem cells for individual people. These iPSCs have the potential to become any cell in the body. We are abl | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| KAISER FOUNDATION HOSPITALS | $3,362,771 | Grant | Trans-NIH Recovery Act Research Support: This application proposes development of a unique resource designed to accelerate scientific progress - a National Research Database (NRDB) of Kaiser Permanente (KP) data that will contain clinical information on almost 30,000,000 current and past members | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| CORNELL UNIVERSITY, INC | $1,443,756 | Grant | Trans-NIH Recovery Act Research Support: One fifth of America's children grow up in poverty. While there is good evidence that this is harmful to health, achievement, and socio-emotional adjustment, very little is known about the brain basis that mediates the detrimental effects of poverty. We a | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $4,000,000 | Grant | Trans-NIH Recovery Act Research Support: The Gulf Coast Transdisciplinary Research Recovery Center for Community Health brings together outstanding academic and public health institutions and centers as a Consortium. The Consortium will coordinate new research studies and projects with existing | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| CHILDRENS HOSPITAL OF PHILADELPHIA | $10,176,187 | Grant | Trans-NIH Recovery Act Research Support: Mental illnesses are common disorders that emerge during childhood and adolescence and many persisting into adulthood, with debilitating consequences. To prevent or intervene in this pathway it is essential to identify premorbid risk factors and early man | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $5,113,630 | Grant | Trans-NIH Recovery Act Research Support: Autism spectrum disorders (ASD) are a group of neuropsychiatric conditions characterized by impairment in the ability to communicate, form relationships, and respond appropriately to the environment. With many autistic individuals having some degree of me | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $521,952 | Grant | Trans-NIH Recovery Act Research Support: Schizophrenia is a common, profoundly disabling disorder that carries a heavy burden for patients and families that is the subject of intensive genetic studies, but the study of epigenetic variation, such as DNA methylation, is an essential complement to | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TREVENA, INC. | $7,639,642 | Grant | Trans-NIH Recovery Act Research Support: Selective Modulation of G-protein coupled receptor (GPCR) signal transduction with biased ligands. One third of today's FDA-approved drugs act on GPCRs, collectively affecting hundreds of millions of people worldwide. Trevena proposes to demonstrate the b | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF KENTUCKY | $1,913,322 | Grant | Trans-NIH Recovery Act Research Support: The long-term objective of our program of research is to improve the cardiovascular (CV) health of inmates by implementation of a state-wide CV risk factor reduction program in prisons. The purpose of the proposed study in male inmates is to test the effe | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $3,066,436 | Grant | Trans-NIH Recovery Act Research Support: Elucidating the structure and function of brain circuits is arguably this century's greatest scientific challenge. Pioneering studies in invertebrates have established that this challenge can be met by combining anatomical circuit diagrams ('connectomes') | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $3,776,244 | Grant | Trans-NIH Recovery Act Research Support: This consortium aims to capitalize on an unprecedented 'grand' opportunity to develop a novel and powerful model of Huntington's disease (HD), a fatal neurodegenerative condition with no current treatment. Skin cells from patients with HD can be reprogram | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| PHARMACEUTICAL PRODUCT DEVELOPMENT, INC. | $2,288 | Grant | Trans-NIH Recovery Act Research Support: Biomarkers for diseases of the nervous system can benefit from advanced proteomic analysis of cerebral spinal fluid (CSF) but some basis biological and analytical parameters of CSF collection, handling, and analysis must first be systematically evaluated. | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $55,502 | Grant | Trans-NIH Recovery Act Research Support: The goals of this research are to elucidate the complex interactions between the transcriptional coactivators CBPjp300, the tumor suppressor p53, and adenovirus ElA. CBP and p300 regulate most transcriptional process in human cells and are essential for c | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $342,296 | Grant | Trans-NIH Recovery Act Research Support: Decreased levels of cell cycle inhibitor p27Kip1 due to excessive degradation occur in a variety of aggressive human tumors. Since reduced p27 expression has been associated with a poor prognosis in many human cancers and resistance to certain anti-tumor | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $354,965 | Grant | Trans-NIH Recovery Act Research Support: Gliomas are the most common type of human brain tumors. Based on clinical and pathological criteria, they can be classified into four grades. The grade III and IV gliomas are malignant tumor. Grade IV glioma is commonly known as glioblastoma, which is one | Health and Human Services, Department of / National Institutes of Health | 9/08/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $139,225 | Grant | Trans-NIH Recovery Act Research Support: During the period of the parent grant we have reported that the ability of chronic lymphocytic leukemia (CLL) cells to avoid apoptosis and accumulate in the circulation of patients is the result of aberrant stabilization of bcl-2 mRNA by the protein nucle | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF HAWAII SYSTEMS | $111,994 | Grant | Trans-NIH Recovery Act Research Support: Research relates to active R01 which examines the role of polyamines and polyamine inhibitors in the pediatric cancer neurolblastoma and is in direct response to the Notice of Availability of Recovery Act Funds for Administrative Supplements NOT-OD-056. | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| RHODE ISLAND HOSPITAL | $199,716 | Grant | Trans-NIH Recovery Act Research Support: This research investigates how chronic infection by the gastric bacterium Helicobacter pylori causes gastric cancer, the second leading cause of cancer death worldwide. Specifically, it focuses on how H. pylori, the main cause of gastric cancer, regulates | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $95,000 | Grant | Trans-NIH Recovery Act Research Support: Due to contracting delays, no Notice of Award has been approved at the Stanford School of Medicine as of this date (03/23/10). As such, while the study remains open, its progress is delayed pending access to funding provided through the NOA. While NIH i | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE | $159,895 | Grant | Trans-NIH Recovery Act Research Support: Almost without exception, patients with localized tumors have better prognoses than patients with metastatic disease. The long-range goal of our studies is to develop safe, effective, systemic treatments for metastatic solid tumors. The basis of the appro | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $301,957 | Grant | Trans-NIH Recovery Act Research Support: ARRA - Effect of Male Circumcision on Penile HPV Infection As an administrative supplement for the ongoing study of the Effect of Male Circumcision on Penile HPV infection RO1 CA114773-01 grant, we will newly hire a full-time post doctoral student employ | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC. | $206,351 | Grant | Trans-NIH Recovery Act Research Support: Human leukemia/lymphoma is often associated with acquisition of a constitutive activation of the Jak/STAT pathway. Jak activation leads to increased survival and increased proliferation of tumor cells as well as metastasis. While in some instances the pat | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $535,893 | Grant | Trans-NIH Recovery Act Research Support: For two decades, PSA testing has been employed routinely in clinical practice. The outstanding success of this approach, with its emphasis on early detection of malignancy, can be judged by one key distinction between today's prostate cancer patient popul | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC. | $833,260 | Grant | Trans-NIH Recovery Act Research Support: Tumors arising from non-neural or glial tissue of the brain ('gliomas') constitute one of the most lethal human cancers. Few case-control studies of glioma have been undertaken, and the etiology of the tumor is largely unknown. However, the descriptive ep | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $145,643 | Grant | Trans-NIH Recovery Act Research Support: The quality of life and survival for cancer patients are considerably threatened by liver metastases. While surgical resection is often not possible and systemic chemotherapy is largely ineffective, promising interventional therapeutic techniques are avai | Health and Human Services, Department of / National Institutes of Health | 9/08/2009 |
| GROUP HEALTH COOPERATIVE | $319,554 | Grant | Trans-NIH Recovery Act Research Support: As a supplement to our parent grant titled G?Commonly Used Medications and Breast Cancer RecurrenceG?, we propose a comparative effectiveness study of adjuvant oral endocrine therapy (i.e., tamoxifen (TAM) and aromatase inhibitors (AIs)) for the treatment | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $219,403 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Great effort has been made in developing tumor-targeted gene delivery, but no attention has been given to targeting the therapeutic gene products that are transcribed and translated from genes transfected in normal tis | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| NEVADA CANCER INSTITUTE | $513,524 | Grant | Trans-NIH Recovery Act Research Support: Melanoma is the most rapidly increasing malignancy in the United States. While it accounts for only 4% of all skin cancers, it is responsible for nearly 80% of all skin cancer deaths. If detected early, the disease is easily treated; however, once the dis | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| BROWN UNIVERSITY IN PROVIDENCE IN STATE OF RI AND PROVIDENCE PLANTATIONS | $408,096 | Grant | Trans-NIH Recovery Act Research Support: Bladder cancer is the most common urologic malignancy and is responsible for an appreciable number of deaths each year in the USA. Aside from tobacco smoking and certain occupational exposures, the etiology of this malignancy remains largely unexplained. | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $57,990 | Grant | Trans-NIH Recovery Act Research Support: With continuous improvements in cancer treatment, there is a growing population of long-term cancer survivors who are at a significant risk for late effects induced by ionizing radiation (IR) and chemotherapy, such as residual bone marrow (BM) injury, gen | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |