Listing all stimulus spending by amount, in descending order. Return to National Institutes of Health page
Amount refers to both the amount of stimulus funding going toward the project and the face value of the loan.
| Recipient | Amount | Type | Description | Federal Dept./Agency | Date |
|---|---|---|---|---|---|
| UNIVERSITY OF SOUTH FLORIDA | $423,402 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Autism spectrum disorders (ASD) affect approximately 1 out of 150 children and adolescents in the United States, making them one of the most common neurobiological conditions. Comorbid anxiety disorders affect as many | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| WASHINGTON UNIVERSITY, THE | $678,896 | Grant | Trans-NIH Recovery Act Research Support: Elderly persons who have suffered a disabling medical event, such as a hip fracture, are likely to develop depression. Late-life depression (LLD) adversely affects acute medical rehabilitation, increasing the risk for persistent depression and disability. | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) | $774,400 | Grant | Trans-NIH Recovery Act Research Support: The granuloma developed in the host in response to Mycobacterium tuberculosis (Mtb) is a protective structure that curtails the spread of the pathogen and controls reactivation of latent/persistent Mtb. Despite this knowledge, the molecular pathways that | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| TRUSTEES OF PRINCETON UNIVERSITY, THE | $390,607 | Grant | Trans-NIH Recovery Act Research Support: We propose to develop and apply a comprehensive set of experimental and computational methods for revealing the genetic basis of antibiotic tolerance in Escherichia coli. At the core of our approach is a microarray-based genetic footprinting technology th | Health and Human Services, Department of / National Institutes of Health | 5/22/2009 |
| TUFTS MEDICAL CENTER, INC. | $707,949 | Grant | Trans-NIH Recovery Act Research Support: Lyme disease is the most common vector-borne disease in the U.S. and and an important public health problem whose incidence continues to increase. In our preliminary work, we have shown that Borrelia burgdorferi, the causative agent of Lyme disease, induc | Health and Human Services, Department of / National Institutes of Health | 6/16/2009 |
| THE GEORGE WASHINGTON UNIVERSITY | $782,500 | Grant | Trans-NIH Recovery Act Research Support: Inflammatory destruction of target organs in autoimmune diseases, including rheumatoid arthritis (RA), begins with the emigration of effector cells from the microcirculation. Suppression of inflammatory leukocyte extravsation could provide protection aga | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $189,191 | Grant | Trans-NIH Recovery Act Research Support: Shigella, a major etiologic agent of diarrhea, dystentry, and mortality worldwide, causes disease by invading and disseminating through the colonic mucosa. Shigella sp. CDC/NIAID Category B priority pathogens. After inducing their own entry into cells, | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| PURDUE UNIVERSITY | $600,412 | Grant | Trans-NIH Recovery Act Research Support: Most bacterial viruses (?bacteriophages? or just ?phage?) are highly efficient in their ability to infect their often very specific bacterial hosts. In general, only one or a few viral particles are necessary to successfully infect one bacterium. As a con | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $363,985 | Grant | Trans-NIH Recovery Act Research Support: Francisella tularensis is an extremely virulent Gram negative bacterial pathogen capable of causing rapidly progressing lethal infections in literally hundreds of diverse animal species, including humans. Transmission from infected animals to humans occur | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| SEATTLE CHILDREN'S HOSPITAL | $378,005 | Grant | Trans-NIH Recovery Act Research Support: National surveillance of emerging MDR in pediatric Enterobacteriaceae infections The growing problem of antimicrobial resistance is well recognized. Infections with multi-drug resistant organisms are challenging to treat, and are associated with increase | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, THE | $424,780 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this proposal is to determine the mechanisms for the loss of B cell tolerance to phospholipids and for tissue damage by anti-phospholipid antibodies in NZW/BXSB F1 (W/B) mice. W/B mice develop both proliferative glomerulonephritis and spon | Health and Human Services, Department of / National Institutes of Health | 7/23/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $657,523 | Grant | Trans-NIH Recovery Act Research Support: Despite decades of research, the immunological correlates of protection against HIV-1 infection in humans or SIV infection in nonhuman primates remain poorly understood. In contrast, studies on Friend retrovirus (FV)infection in mice highlighted the impor | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $1,095,218 | Grant | Trans-NIH Recovery Act Research Support: Mycobacterium tuberculosis (Mtb) grows in human macrophages, the principal host cell, where it occupies a niche allowing it to replicate without being recognized by the host. Attenuated Mtb induce apoptosis of the host macrophages resulting in containment | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| THE HOSPITAL FOR SPECIAL SURGERY FUND INC | $775,708 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this study is to evaluate ultra-short echo (UTE) imaging as a buiomatker of meniscal integrity by biomechanical and histological measures in an ovine model of meniscal repair: site-specific meniscal T2* values will be correlated with corres | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| ISA ASSOCIATES INC | $993,116 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area 06 G?? Enabling Technologies G?? and specific Challenge Topic, 06-DA-104: Development of new technologies to change patient and provider behaviors to improve adherence. Since the advent of highly active an | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| RAND CORPORATION, THE | $998,879 | Grant | Trans-NIH Recovery Act Research Support: Enormous unmet needs for alcohol prevention and treatment exist among individuals arrested for driving under the influence (DUI), as nearly one third recidivate and have a subsequent arrest. The DUI arrest represents a critical opportunity for early inter | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $734,068 | Grant | Trans-NIH Recovery Act Research Support: Surface Enhanced Transmission Mode Desorption Electrospray Ionization for Metabolite Profiling from Dried Blood Spots This application addresses broad Challenge Area (03) Biomarker Discovery and Validation, and specific Challenge Topics, 03-AG-101: Novel | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| BROWN UNIVERSITY IN PROVIDENCE IN STATE OF RI AND PROVIDENCE PLANTATIONS | $666,473 | Grant | Trans-NIH Recovery Act Research Support: Effectiveness of Feeding Tubes Among Persons with Advanced Cognitive Impairment This application addresses broad challenge area (05) Comparative Effectiveness Research, Challenge Topic 05-AG-101: Data Infrastructure for Post-Marketing Comparative Effectiv | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| THE VANDERBILT UNIVERSITY | $998,268 | Grant | Trans-NIH Recovery Act Research Support: This integrated laboratory and clinical proposal seeks to validate molecular determinants affecting [18F]-FLT PET imaging as a biomarker of response to targeted therapeutics in colorectal cancer (CRC). The introduction of molecularly targeted therapies to | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF ROCHESTER | $695,098 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad challenge area (10) Information Technology for Processing Health Care Data for Research' and specific challenge topic 10-CA-102 Predictive Mathematical Models of Normal and Cancer Processes. This proposal will develop mat | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF ALASKA ANCHORAGE | $1,171,521 | Grant | Trans-NIH Recovery Act Research Support: In response to the critical needs in many health care professions, there has been a rapid increase in health care education and training programs at UAA over the past decade. Several excellent programs have developed to lead students into health care and | Health and Human Services, Department of / National Institutes of Health | 9/19/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $771,788 | Grant | Trans-NIH Recovery Act Research Support: We propose to study the molecular details of ethanol action at extrasynaptic GABA(A) receptors, a subset of inhibitory neurotransmitter receptors implicated as key targets in both acute alcohol action and in adaptation to chronic alcohol exposure. Validat | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| YALE UNIVERSITY | $820,950 | Grant | Trans-NIH Recovery Act Research Support: The treatment of P. aeruginosa infections is often difficult: these bacteria are highly resistant to most antibiotics and grow as biofilms that cannot be effectively eradicated by antimicrobials or the human immune response. Completion of these experiment | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $845,000 | Grant | Trans-NIH Recovery Act Research Support: Nucleotide-binding oligomerization domain 2 (NOD2) is a monocyte-restricted member of a protein family critically involved in the activation of NF-?B in response to certain intracellular microbial infection. Dysfunctional mutations in the NOD2 gene underl | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF MASSACHUSETTS | $681,638 | Grant | Trans-NIH Recovery Act Research Support: To maintain tissue homeostasis and normal functions, damaged cells need to be replaced or repaired. In mammals, such process requires extensive cell proliferation. A consequence of this massive proliferation is the accumulation of mutations, some of which | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $1,765,036 | Grant | Trans-NIH Recovery Act Research Support: Title: SYSTEMS APPROACH TO SJOGREN'S SYNDROME PATHOGENESIS (SASSP) This proposal aims to test the hypothesis that the salivary gland pathologies in primary Sj+?gren's syndrome (pSS) are mediated by aberrant activities of key intracellular/intercellular ne | Health and Human Services, Department of / National Institutes of Health | 4/29/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $633,257 | Grant | Trans-NIH Recovery Act Research Support: Stem cells are defined by the fact that they divide asymmetrically, on the one hand side giving rise to a daughter cell that continues to divide, and on the other hand to cells that differentiates. Adult stem cells are under intensive study with the goal | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF MASSACHUSETTS | $771,298 | Grant | Trans-NIH Recovery Act Research Support: The broad goal of this work is to use the C. elegans model system to understand the genetic and molecular mechanisms underlying the developmental regulation of microRNA expression. There are more than 150 distinct microRNA genes in C. elegans, including m | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $710,061 | Grant | Trans-NIH Recovery Act Research Support: EXAMINING THE EFFECTS OF HIGH PROTEIN DIET ON ADIPOSITY AND CARDIAC PERFORMANCE IN HEART FAILURE PATIENTS WITH INCREASED BODY MASS AND DIABETES. The overall goal of the study is to test the hypothesis that a high protein diet will result in significantly | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| YALE UNIVERSITY | $1,987,576 | Grant | Trans-NIH Recovery Act Research Support: A consistently replicated biological phenotype in autism spectrum disorders (ASD) is a larger head circumference (HC) in the first years of life. We hypothesize that increased brain size in ASD is attributable to altered dynamics of cell proliferation and | Health and Human Services, Department of / National Institutes of Health | 9/08/2009 |
| UNIVERSITY OF MASSACHUSETTS | $1,354,091 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this four-year study, 'School Worksite Weight Gain Prevention Intervention Study', is to determine the effectiveness of an ecological worksite intervention compared to a self-directed, print-materials only control group at reducing weight g | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| SAINT LUKE'S HOSPITAL OF KANSAS CITY | $2,121,454 | Contract | : Transforming PCI Informed Consent into an Evidence-based Decision-making Tool. | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC. | $140,076 | Grant | Trans-NIH Recovery Act Research Support: Chlamydia are human pathogens that cause sterility, blindness, pneumonia, and are strongly correlated with the number one cause of death in humans, heart disease. Chlamydia are obligate intracellular bacteria that are perpetuated through a defining bi-pha | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $173,500 | Grant | Trans-NIH Recovery Act Research Support: This R03 grant, 5R03DA025802, entitiled TAAR1 polymorphisms in rhesus monkeys supports a research project that will run for two years. In this grant, we assess the function of Trace Amine Associated receptor 1 (TAAR1) and identifying novel polymorphisms i | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| UNIVERSITY OF MASSACHUSETTS | $228,750 | Grant | Trans-NIH Recovery Act Research Support: Understanding how cells regulate their internal architecture is important for understanding cellular fuction, as the inside of the cell is highly organized. Furthermore, cells in disease states frequently take on morphologies distinct from healthy cells | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| BENNINGTON COLLEGE CORPORATION | $231,235 | Grant | Trans-NIH Recovery Act Research Support: Systems Biology Approaches to Identify HSP90 Functions and Substates: This grant will allow Dr. McClellan to continue her research aimed at identifying novel substrates and functions of the Hsp90 molecular chaperone. Molecular chaperones, which are the f | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| YALE UNIVERSITY | $455,125 | Grant | Trans-NIH Recovery Act Research Support: West Nile virus, an NIAID category B priority pathogen, emerged in the United States in 1999, causing over 11,000 cases of neuroinvasive disease and 1,103 fatalities. Because the threat of emerging viral diseases raises new dangers for public safety, it i | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| TRUDEAU INSTITUTE, INC. | $504,500 | Grant | Trans-NIH Recovery Act Research Support: The mucosal surfaces of the respiratory tract are in direct contact with the surrounding environment, and as such are a primary portal of entry for human pathogens such as influenza and parainfluenza viruses. The significant public health threat that the | Health and Human Services, Department of / National Institutes of Health | 7/23/2009 |
| UNIVERSITY OF MASSACHUSETTS | $451,511 | Grant | Trans-NIH Recovery Act Research Support: T cells are involved in many beneficial aspects of the immune system including the control of infections, tumor surveillance, generation of B cell responses, and regulation of homeostasis. In some instances, activated T cells are also detrimental to a ho | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $326,731 | Grant | Trans-NIH Recovery Act Research Support: By escaping signals that normally constrain dividing cells, Cancer Stem Cells display unlimited proliferative potential. Cancer Stem Cells are thought to arise from the misregulation of normal stem cells that are capable of undergoing symmetric divisions | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC. | $400,810 | Grant | Trans-NIH Recovery Act Research Support: The long-term objective of this application is to regenerate a patient-specific temporomandibular joint (TMJ) condyle using a process free of solvents, particulates and polymerization initiators. In a broader sense, this technology can be readily applied | Health and Human Services, Department of / National Institutes of Health | 4/30/2009 |
| YALE UNIVERSITY | $270,000 | Grant | Trans-NIH Recovery Act Research Support: The world faces a wide array of Global Health challenges, including the HIV pandemic, the threat of an influenza pandemic, the resurgence of tuberculosis and malaria, continued malnutrition in low-income countries, and the spread of cigarette smoking and | Health and Human Services, Department of / National Institutes of Health | 5/06/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $422,938 | Grant | Trans-NIH Recovery Act Research Support: Anti-microbial T cell responses play a major role in determining the outcome of infection. Chronic infections are often distinguished by T cell responses that are not able to fully eliminate the pathogen. The mechanisms that explain this failure of T cell | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $338,950 | Grant | Trans-NIH Recovery Act Research Support: The ability to control neuronal function in cells, tissues, and living animals is critical for understanding the role of specific proteins in neural function and behavior. Controlling protein function by light has emerged as a popular approach due to its | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| WHITEHEAD INSTITUTE FOR BIO-MEDICAL RESEARCH | $812,391 | Grant | Trans-NIH Recovery Act Research Support: Somatic reprogramming efforts have focused on using embryonic stem (ES) cells and their differentiated progeny to regenerate various adult tissues depleted by aging or by various pathological processes. Alternatively, this goal might be reached via experi | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| CHILDREN'S HOSPITAL & RESEARCH CENTER | $999,570 | Grant | Trans-NIH Recovery Act Research Support: The alarming increase in the prevalence of obesity is a cause of great concern given its association with many adverse health conditions, including insulin resistance and type 2 diabetes, which are associated with increased cardiovascular disease (CVD) ri | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| YALE UNIVERSITY | $946,752 | Grant | Trans-NIH Recovery Act Research Support: The use of fluorescent protein tags has revolutionized all aspects of cell biology research during the last 15 years, enabling analysis of the dynamic structures within living cells. The cloning of Green Fluorescent Protein (GFP) and the subsequent develo | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF MEMPHIS | $850,248 | Grant | Trans-NIH Recovery Act Research Support: Compared to handwritten charts notes, various emerging technologies could facilitate self-documenting encounters. These technologies include speech recognition and menu-driven systems, using tablet PCs and handheld devices. However, in order for these eme | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| YALE UNIVERSITY | $918,498 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (15) Translational Science and specific Challenge Topic (15-MH-105) Strategies to Support Uptake of Interventions within Clinical Community and Settings. Implementation of evidence-based treatments into ment | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $999,925 | Grant | Trans-NIH Recovery Act Research Support: This project, in response to the Enabling Technologies challenge area 06-MH-103 G?New Technologies for Neuroscience ResearchG?, will provide a powerful, content-driven approach to the identification of brains having similar geometry and shape, the cluster | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $961,612 | Grant | Trans-NIH Recovery Act Research Support: The overall purpose of the research project is to develop, using click chemistry approaches, novel antibiotics with improved activity against the major periodontal pathogens, bacteria that cause serious gum disease and tooth loss. Timely and cost-effectiv | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $869,165 | Grant | Trans-NIH Recovery Act Research Support: Oral cancer survival has not improved for the past 20 yrs. Recently, cancer stem cell (CSC)- based therapies have shown their potential to control cancer recurrence. However, the lack of in vivo models has hindered attempts to identify markers of oral CSC | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $951,326 | Grant | Trans-NIH Recovery Act Research Support: The purpose of the pilot is to estimate the effect size of the new IMET/TE system in reducing tobacco, drug, and alcohol use. We will use these estimates and our pilot study experience to design a future study comparing iMET/TE to TAU in a much larger po | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| MAYO CLINIC | $945,723 | Grant | Trans-NIH Recovery Act Research Support: ADPKD is a common cause of end stage renal disease (ESRD) and, hence, is of significant medical importance and economic burden. A number of different potential therapies are now in Phase III trials with the prospects for an effective therapy in the next f | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $964,644 | Grant | Trans-NIH Recovery Act Research Support: Over one million patients each year are newly diagnosed with digestive diseases, such as inflammatory bowel diseases and colorectal cancer. Digestive tracts are directly accessible by endoscopy for the diagnosis and therapy. However, current imaging techn | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF MIAMI | $902,641 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to identify objective, quantitative bio-molecular parameters that correlate with healing outcomes for diabetic foot ulcers (DFUs). Chronic non-healing DFUs are a widespread and serious clinical problem with high rates of morbid | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| KAISER FOUNDATION HOSPITALS | $975,953 | Grant | Trans-NIH Recovery Act Research Support: Recent studies suggest that metformin is the best oral medication for initial treatment of diabetes and that starting metformin immediately when diabetes is first detected, rather than waiting until blood sugars reach a somewhat higher target level, could | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $998,989 | Grant | Trans-NIH Recovery Act Research Support: 1. Establishing the coordinating study center (CSC) The electronic database is completed. The grant support continues to help retain positions within the Clinical Research Program at CHB to help with data collection, maintenance of the database and analys | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $980,401 | Grant | Trans-NIH Recovery Act Research Support: Challenge Area (11) Regenerative Medicine: 11-DK-101: Promote regeneration and repair in the digestive system, liver, pancreas, hematology, kidneys and urological system. Fecal incontinence is a condition with ramifications that extend well beyond the phy | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $496,842 | Grant | Trans-NIH Recovery Act Research Support: It is becoming increasingly evident that prevention of child obesity must begin very early in life, as the prevalence of child overweight in the U.S. in the past 20 years has increased even in the youngest age groups. One of the key risk factors for later | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $985,445 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this study is to investigate potential mechanisms responsible for the delay in type 2 diabetes mellitus (T2DM) onset observed after ileal interposition in UCD-T2DM rats. We hypothesize that IT surgery performed on prediabetic rats from our | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $999,998 | Grant | Trans-NIH Recovery Act Research Support: This proposal, entitled Vascularization of Polymeric Tissue Beds, seeks to address the broad Challenge Area of (11) Regenerative Medicine, and the specific Challenge Topic of vascular networks in engineered tissues: 11-EB-101. The major impediment to prog | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $999,997 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad challenge area (14) Stem Cells and the specific challenge topic 14-EB-101 Synthetic Delivery Systems for Generating Pluripotent Stem Cells The recent advent of cell reprogramming as a means of producing induced pluripotent | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| NORTH CAROLINA STATE UNIVERSITY | $558,529 | Grant | Trans-NIH Recovery Act Research Support: K-12 schools across the nation are implementing or considering implementing various curricula that use engineering. From high school curricula that are fairly comprehensive (i.e. Project Lead the Way) to textbooks intended for middle or high school cours | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| DUKE UNIVERSITY | $993,020 | Grant | Trans-NIH Recovery Act Research Support: This application addresses the broad Challenge Area (08), Genomics, and the specific Challenge Topic (08-ES-106), The role of environmental exposure in copy number variation (CNV). CNV events are deletions or duplications that are too small to be recogniz | Health and Human Services, Department of / National Institutes of Health | 9/26/2009 |
| WISTAR INSTITUTE OF ANATOMY & BIOLOGY | $959,491 | Grant | Trans-NIH Recovery Act Research Support: This project addresses 3D or virtual models to reduce the use of animals in research: Creation of miniature multi-cellular organs for high-throughput screening for chemical toxicity testing. Our long-term objective is to decrease the use of animals for to | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF MONTANA SYSTEM | $926,031 | Grant | Trans-NIH Recovery Act Research Support: The University of Montana's Air Toxics under the Big Sky program has been used to educate high school students in rural areas of Montana, Idaho, and Alaska about indoor air quality. In collaboration with the Alaska Native Tribal Health Consortium (ANTHC) | Health and Human Services, Department of / National Institutes of Health | 9/26/2009 |
| NEW YORK UNIVERSITY (INC) | $798,027 | Grant | Trans-NIH Recovery Act Research Support: NIH identified five gateway areas to increasing public trust in clinical research: building trust through community partnerships; building relationships with patients; building partnerships with community providers; building trust in scientists; and build | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF KENTUCKY | $996,474 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area 15: Translational Science and specific Challenge Topic 15-ES-101: Effects of environmental exposures on phenotypic outcomes using non-human models. Approximately 8.6 million Americans perform shift work, whi | Health and Human Services, Department of / National Institutes of Health | 9/27/2009 |
| UNIVERSITY OF OREGON | $997,291 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to develop and evaluate a theory-driven pedagogic minimal Geographic Information Systems (mGIS) interface to enhance spatial thinking, analysis, and learning in science, technology, engineering, and mathematics (STEM) disciplin | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| DUKE UNIVERSITY | $999,860 | Grant | Trans-NIH Recovery Act Research Support: Millions of individuals world-wide use aspirin for cardioprotection yet clinicians currently lack a reliable tool to accurately identify those patients who will develop myocardial infarction (MI) or stroke despite aspirin use. Our long-term goal is to per | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK INC | $840,710 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (06) Enabling Technologies and specific Challenge Topic 06-GM-102* .Chemist/biologist collaborations facilitating tool development. The objective of this grant is to develop fluorescent chemical tags that bo | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| DUKE UNIVERSITY | $998,487 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (06) Enabling Technologies and specific Challenge Topic, 06-HD-101 Improved interfaces for prostheses to improve rehabilitation outcomes. Considerable progress has been made during the last decade in the dev | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $989,965 | Grant | Trans-NIH Recovery Act Research Support: This study will determine the effectiveness, mechanism, and safety of 5 treatments of 6-Hz primed low-frequency repetitive transcranial magnetic stimulation (rTMS) applied to the non-stroke hemisphere and combined with constraint induced therapy (CIT) to | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF PITTSBURGH THE | $956,840 | Grant | Trans-NIH Recovery Act Research Support: Regenerative medicine approaches for the reconstitution of missing or injured tissues and organs involves the use of scaffolds, cells, and bioactive molecules. The use of biologic scaffolds seeded with cells is a common approach and several applications | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $996,108 | Grant | Trans-NIH Recovery Act Research Support: Develop the three portals for entry of patient generated family history data integrated with an EHR. The pathways will include: : (1) computer tablets in waiting rooms to complete the MFHP, (2) a secure internet portal to transfer data collected by patien | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| NORTHWESTERN UNIVERSITY | $751,077 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad challenge area (01) Bioethics, and specific Challenge Topic, 02-HG-101: Informed Consent and Data Access Policies. Our project title is 'The Impact of Data Access Policies on Biobank Participation'. The NIH data access pol | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $773,284 | Grant | Trans-NIH Recovery Act Research Support: The number of human samples undergoing whole-genome sequencing is expected to increase dramatically in the next few years, as advances in next-generation sequencing technologies continue to lower the cost of sequencing. In addition to detection of sequenc | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $925,499 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area: (04) Clinical Research and specific Challenge Topic: 04- HL-104: Perform Secondary Analyses of Existing Data to Answer Important Clinical and Preventive Medicine Research Questions. Coronary revascularizati | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $492,935 | Grant | Trans-NIH Recovery Act Research Support: ARRA - Weight-Related Measures and CVD in African American and White Adults We will use the population-based samples of African American and White men and women in the Atherosclerosis in Communities Study (ARIC) to examine associations of a obesity-relat | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| CHILDRENS HOSPITAL OF PHILADELPHIA | $831,540 | Grant | Trans-NIH Recovery Act Research Support: We propose to tackle the challenge (06-HL-103) of providing enabling technologies directed towards developing novel quantitative imaging approaches for the measurement of coagulation enzyme function in the intact mouse to improve basic understanding of ce | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $459,286 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (04) Clinical Research, and the specific Challenge Topic 04-HL-103 Assess the role of leukocyte interaction with platelets, erythrocytes, and endothelium in the pathogenesis of heart, lung, and blood disease | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $997,013 | Grant | Trans-NIH Recovery Act Research Support: A fundamental limitation in understanding the pathogenesis of congenital heart disease has been the lack of model systems to study human heart development. Studies in model organisms have been informative, but clearly interspecies differences exist that i | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $518,832 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Challenge Area: (03) Biomarker Discovery and Validation Challenge Topic: Discovery of biomarkers for disease risk, progression or response to therapy in diseases of interest to NIDDK. 03-DK-101 Title: Biomarkers in Dia | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| MAYO CLINIC | $983,862 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (08) Genomics, and specific Challenge Topic 08-CA-101* Augmenting Genome-Wide Association Studies. The development of glioblastoma (GBM) has been hypothesized to be associated with relatively common germline | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| WASHINGTON UNIVERSITY, THE | $999,998 | Grant | Trans-NIH Recovery Act Research Support: A wide variety of genetic or drug-induced mental health disorders have been linked to problems in regulation of gene expression. Gene expression is regulated by specialized proteins called transcription factors (TFs), which work with a few nuclear adaptor | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $997,605 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (13): Smart Biomaterials - Theranostics, and specific Challenge Topic, 13-NS-101: Developing novel biomaterials to interfaces with neural activity. Implantable neural int | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $813,511 | Grant | Trans-NIH Recovery Act Research Support: Epilepsy affects over 1% of the US population, and up to 30% of people suffering from epilepsy do not respond to conventional antiepileptic drugs (AEDs). The newly FDA-approved AED vigabatrin has improved efficacy in this population yet its use has been l | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $930,517 | Grant | Trans-NIH Recovery Act Research Support: The Food and Drug Administration Amendments Act (FDAAA) requires FDA to obtain access to multiple distributed large claims and electronic medical records databases covering 100 million lives by 2012. The pooled database will provide sufficient size to stu | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF HOUSTON SYSTEM | $961,864 | Grant | Trans-NIH Recovery Act Research Support: Dramatic advancements in nanomagnetic sensor technology, driven by the needs of magnetic data storage industry, have now brought us disk drives with magnetic read heads addressing features of less than 80nm across, at a wholesale cost of about | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $999,986 | Grant | Trans-NIH Recovery Act Research Support: The goals of this project are to perform assay related to diabetes, lipid metabolism and coronary disease in the Pakistan Risk of Myocardial Infarction Study (PROMIS). This project will generate novel data regarding the links between T2DM and CHD in Paki | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| NORTHWESTERN UNIVERSITY | $1,011,810 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Abstract: The mechanisms of action of alcohol (ethanol) and nicotine on the nervous system have been studied extensively. However, it was not until a few years ago that microglia were recognized as an important site of | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $4,000,000 | Grant | Trans-NIH Recovery Act Research Support: We propose to develop a unique approach to promoting wound healing by engineering of the wound bed. The unique approach we propose will result in changing the intrinsic properties of the wound bed to promote favorable outcomes. We will exploit recent adva | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | $1,673,946 | Grant | Trans-NIH Recovery Act Research Support: Burns are one of the most common and devastating injuries known to mankind. Each year in the US approximately 500,000 patients with burns present to emergency departments. Of 40,000 annual hospitalizations, 25,000 burn victims are admitted to specialized | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| AMERICAN COLLEGE OF RADIOLOGY, THE | $2,056,531 | Grant | Trans-NIH Recovery Act Research Support: The Radiation Therapy Oncology Group (RTOG), which is one of the largest and most established cooperative groups in oncology, has developed a recursive partitioning analysis (RPA) model for malignant glioma patients, using primarily clinical and demograph | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $3,990,198 | Grant | Trans-NIH Recovery Act Research Support: The overarching goal of this project is to develop a coordinated, multidisciplinary center for the generation and synthesis of evidence to support the translation of genomic tests into improvements in cancer prevention, screening, diagnosis, treatment and | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $1,912,026 | Grant | Trans-NIH Recovery Act Research Support: The award 'Predicting pancreatic cancer responses for a Parp inhibitor-based clinical trial' is part of a larger effort by our group to identify the genetic basis of pancreatic cancer and to use that information to develop personalized therapies to fight | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| BROAD INSTITUTE, INC., THE | $4,504,725 | Grant | Trans-NIH Recovery Act Research Support: Our understanding of how cancers begin, survive and progress is rapidly expanding through advances in cancer genomics and modern cancer biology. In assembling the Target Discovery and Development Network (TDDN), the NCI has undertaken the mission of ide | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | $1,864,257 | Grant | Trans-NIH Recovery Act Research Support: It is now quite clear that a subset of patients with metastatic melanoma treated with CTLA-4 blocking antibodies have durable clinical benefit. The experience of our group and others leads us to several vital questions which require answers so that more p | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF MARYLAND | $936,985 | Grant | Trans-NIH Recovery Act Research Support: There is increasing evidence that antibodies targeting the CD4 induced (CD4i) epitopes on the HIV envelope spike can facilitate control of viremia and quite possibly protection from transmission after exposure (reviewed in (1, 2)). We have developed a gp1 | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| GROUP HEALTH COOPERATIVE | $3,988,809 | Grant | Trans-NIH Recovery Act Research Support: Improvements in cancer screening effectiveness, higher participation rates and faster introduction of new screening tests could have pronounced effects on the health of the community by reducing cancer burden. Cancer screening effectiveness in real-world | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF MARYLAND | $984,910 | Grant | Trans-NIH Recovery Act Research Support: Lymphocytes bearing high levels of FasL are known to suppress cell-mediated immunity and destroy the efficacy of DNA vaccines. Their ability to kill the antigen-presenting cells can be eliminated by several different mechanisms and we are exploring a numb | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $997,466 | Grant | Trans-NIH Recovery Act Research Support: HIV infection is associated with increased incidences of multiple tumors, many of which are associated with oncogenic tumor viruses like KSHV, Epstein-Barr virus (EBV), or human papillomavirus (HPV). HIV infection is a worldwide health issue affecting bot | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| JOSLIN DIABETES CENTER, INC. | $1,174,584 | Grant | Trans-NIH Recovery Act Research Support: Zeiss Laser Scan Microscope (LSM) 510-duo - Recent advances in technology of confocal microscopy have opened new avenues for understanding the biology of cells and their interactions with other cells. For example, now that we can examine living cells, we | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $236,458 | Grant | Trans-NIH Recovery Act Research Support: A new era of genetic research is now upon us with the arrival of massively parallel, high throughput, whole genome DNA sequencers. These new instruments allow avenues of genetic inquiry for advanced scientific laboratories that were impossible until now | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL | $760,639 | Grant | Trans-NIH Recovery Act Research Support: This project has not started here and is in process of being relinquished to the PI's new Institution. | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $17,863,520 | Grant | Trans-NIH Recovery Act Research Support: This application proposes large-scale sequencing and genotyping in type 2 diabetes (T2D) case-control samples, addressing one of the major questions in human genetics: how and to what extent can insights into disease etiology be advanced by studying low f | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $1,493,880 | Grant | Trans-NIH Recovery Act Research Support: Bisphenol A (BPA) is one of the highest production chemicals in the world. It is used in polycarbonate beverage containers, food packaging, linings of food cans, and sealants for teeth. Public health concerns have been raised about BPA because recent stud | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF TENNESSEE | $81,959 | Grant | Trans-NIH Recovery Act Research Support: Tuberculosis is a leading AIDS-associated, opportunistic infection and globally it has been estimated that twenty percent of AIDS patients die from tuberculosis. In this study we propose to explore and develop a novel class of nitroaromatic anti-tuberculo | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| DUKE UNIVERSITY | $2,630,773 | Grant | Trans-NIH Recovery Act Research Support: The need for a more efficient and effective infrastructure for clinical research has been articulated by ARRA, as well as by the NIH clinical roadmap initiative. One of the greatest national inefficiencies of the current model of clinical research is the | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $2,047,144 | Grant | Trans-NIH Recovery Act Research Support: The face distinguishes one human being from another. When the face is disfigured from injuries, tumor resection, congenital anomalies or infectious diseases, the patient experiences both physical and psychosocial trauma, and therefore has strong desire fo | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $994,174 | Grant | Trans-NIH Recovery Act Research Support: Modulating Cortical and Sub-cortical Brain Circuits in Chronic Facial Pain Chronic pain, especially facial pain is difficult to treat because it is associated with an enormous diversity of nervous system alterations. Characterizations of these changes at | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF IOWA, THE | $1,834,345 | Grant | Trans-NIH Recovery Act Research Support: This topic specifically targets developing a deep and diverse understanding of genetic maps and recombination within and between species, which is what our proposal intends to study. Project Title: Fine-scale recombination rate variation within and betwee | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $2,190,865 | Grant | Trans-NIH Recovery Act Research Support: Project Summary/Abstract This application addresses Grand Opportunity: Phase 2 Clinical Trials Program of Novel Therapies for HLB Diseases. Obstructive sleep apnea (OSA) afflicts > 5% of adults and is associated with a 2 to 4-fold increased risk of cardio | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $5,326,080 | Grant | Trans-NIH Recovery Act Research Support: This proposal is in response to the NHLBI's call for 'Novel Methods of Monitoring Health Disparities.' The University of Wisconsin (UW) School of Medicine and Public Health (SMPH) and its partners propose to build an innovative research network to monitor | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| EMERGENT PRODUCT DEVELOPMENT GAITHERSBURG INC. | $5,351,252 | Grant | Trans-NIH Recovery Act Research Support: Advance the development of the next generation anthrax vaccine, dmPA7909, to meet the nation's needs for an anthrax vaccine which will facilitate the following: 1. Rapid Immune response following 2-3 doses 2. Long-term stability to facilitate ambient tem | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY M | $1,616,449 | Grant | Trans-NIH Recovery Act Research Support: This project will produce two bivalent dengue vaccine constructs based on adenovirus vectors. A tetravalent vaccine comprising two bivalent components will be tested in pre-clinical animal model systems. | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| COLD SPRING HARBOR LABORATORY | $2,505,191 | Grant | Trans-NIH Recovery Act Research Support: Self-renewal is essential for the homeostasis and lifetime maintenance of many organ systems. The process of self-renewal is carried out by rare populations of adult stem cells whose key features are multilineage potential and repopulating capacity. Blood | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $4,700,000 | Grant | Trans-NIH Recovery Act Research Support: Coronary heart disease is the leading cause of mortality in both men and women worldwide and incidence is highly correlated with levels of cholesterol and triglycerides (fat) in the blood. Plasma concentrations of LDL and HDL cholesterol, as well as trig | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON | $27,554,408 | Grant | Trans-NIH Recovery Act Research Support: This research proposal, entitled 'Building on GWAS for NHLBI-diseases: the U.S. CHARGE consortium', will leverage existing population, laboratory and computational resources to identify susceptibility genes underlying genome-wide significant and well-repl | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $1,934,524 | Grant | Trans-NIH Recovery Act Research Support: The purpose of the award is to translate important new concepts in cellular therapies to the clinic. The project will focus on 4 key projects using different cellular based therapeutics that have shown exceptional promise in preclinical models and are rea | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF WASHINGTON | $25,027,469 | Grant | Trans-NIH Recovery Act Research Support: This application addresses the NHLBI-RFA-OD-09-004 for Large-scale DNA Sequencing and Molecular Profiling of Well-phenotyped NHLBI Cohorts. We propose to establish a sequencing center to perform the production-level resequencing of exomes from 10,000 geno | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $1,184,419 | Grant | Trans-NIH Recovery Act Research Support: We propose a method for answering critical questions concerning the social determinants of health and health disparities by linking 30 years of comprehensive, nationally-representative sociological data to prospective mortality data containing specific ca | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $6,354,022 | Grant | Trans-NIH Recovery Act Research Support: Schizophrenia is a common profoundly disabling disorder that carries a heavy burden for patients and families and is the subject of intensive genetic studies. The study of epigenetic variation is an essential complement to conventional genetic disease stu | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF MARYLAND | $2,204,914 | Grant | Trans-NIH Recovery Act Research Support: The muscular dystrophies are complex genetic diseases characterized by inherited or sporadic defects in genes that encode muscle proteins. Although Duchenne (DMD), Becker, limb girdle, congenital, facioscapulohumeral, myotonic, oculopharyngeal, distal, an | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $3,782,000 | Grant | Trans-NIH Recovery Act Research Support: iPS Cells As Models of ALS: To gain an understanding of the mechanisms underlying any given disease requires access to relevant cell classes on the same genetic background. Although ALS research has seen significant advances over recent years, this precon | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| GEORGETOWN UNIVERSITY (THE) | $3,907,801 | Grant | Trans-NIH Recovery Act Research Support: Parkinson's disease (PD) is a neurodegenerative disorder characterized by death of substantia nigra (SN) dopamine neurons (DANs), dopamine deficiency within the striatum and a clinical movement disorder. Most PD is sporadic/idiopathic that may arise from | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| ROCKEFELLER UNIVERSITY FACULTY AND STUDENTS CLUB INC, THE | $999,974 | Grant | Trans-NIH Recovery Act Research Support: This is a proposal to explore the role of RNA dysregulation in the pathogenesis of amyotrophic lateral sclerosis (ALS). The work stems from recent findings that rare patients with familial ALS have mutations in RNA binding proteins. We will use newly deve | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF TOLEDO, THE | $999,998 | Grant | Trans-NIH Recovery Act Research Support: This application addresses the broad challenge area (06) Enabling Technologies and the specific Challenge Topic of 06-ES-102: 3-D or Virtual Models to Reduce Use of Animals in Research: Creation of Miniature Multi-Cellular Organs for High Throughput Scree | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $489,401 | Grant | Trans-NIH Recovery Act Research Support: In this proposal six faculty of the Departments of Biology and of Chemistry at MIT request funding for automated macromolecular crystallization equipment to be installed at MIT's Structural Biology Core Facility. MIT structural biologists have lacked un | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| UNIVERSITY OF CONNECTICUT | $334,703 | Grant | Trans-NIH Recovery Act Research Support: Structural analyses of cellular and tissue components provide important information regarding normal function and pathological conditions. The high-resolution transmission electron microscope and accessories requested in this application will be used to a | Health and Human Services, Department of / National Institutes of Health | 4/27/2009 |
| CORNELL UNIVERSITY, INC | $2,000,000 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this proposal is to facilitate the purchase of a 3T MRI scanner for basic and applied research at Cornell University. This 3T scanner will be the first MRI research instrument at the Cornell Ithaca campus, providing capabilities for imaging | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $167,696 | Grant | Trans-NIH Recovery Act Research Support: In this application, we are requesting an ICP-MS (Inductively Coupled Plasma Mass Spectrometer) for the Metal Ion Core in the Department of Biochemistry and Molecular Biology at OHSU. An ICP-MS determines the concentration for elements from Li to U with h | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| TUFTS MEDICAL CENTER | $127,980 | Grant | Trans-NIH Recovery Act Research Support: Key to the success of gene and gene expression studies is equipment capable of reproducibly measuring levels of gene expression and gene mutations using preciously small amounts of starting material. For both gene and gene expression studies Real-Time PC | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| WAYNE STATE UNIVERSITY (INC) | $500,000 | Grant | Trans-NIH Recovery Act Research Support: The goal of this proposal is to bring an Applied Biosystems 4000 QTrap hybrid tandem mass spectrometer with nano-CD to the Proteomics Core at Wayne State University. This instrument, has unique capabilities for discovery of post translational modification | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| DUKE UNIVERSITY | $267,000 | Grant | Trans-NIH Recovery Act Research Support: Neuroimaging research using parallel acquired functional MRI and high-resolution structural MRI, and dense array electrical recording involves the acquisition of very large data sets that then must be transformed through a series of computation-intensive | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $350,032 | Grant | Trans-NIH Recovery Act Research Support: The primary intent for the confocal core is to substantively advance the science of a selected groups of NIH funded projects here in the Translational Research Building at the University of Pennsylvania. The secondary goals with this new equipment includ | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| RHODE ISLAND HOSPITAL | $499,702 | Grant | Trans-NIH Recovery Act Research Support: Funds are requested for the acquisition of Ultraflex III TOF/TOF 200 MALDI- TOF Mass Spectrometry Imaging System, an up-to-date Ultraflex III TOF/TOF200 modular time-of-flight mass spectrometer together with corresponding software and accessories, to prov | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $1,944,612 | Grant | Trans-NIH Recovery Act Research Support: This award is for $1,944,611.50 in direct costs from the National Center for Research Resources (NCRR) High-End Instrumentation Grant Program (S10) to fund a crucial 3T quasar dual MRI scanner for multimodal and molecular imaging. This new instrumentation | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $102,208 | Grant | Trans-NIH Recovery Act Research Support: Many bacterial pathogens utilize toxins to cause serious disease. For instance, anthrax lethal toxin (LeTx) is one of the primary virulence factors that Bacillus anthracis utilizes to subvert the host immune system and induce cell death, resulting in a ra | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| DUKE UNIVERSITY | $105,520 | Grant | Trans-NIH Recovery Act Research Support: Approaches to therapeutic intervention for food allergies include the prevention of food allergy and the treatment with immunotherapy for an individual with an established allergy [1]. In this proposal, both of these interventions will be developed for ca | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| FLORIDA INTERNATIONAL UNIVERSITY | $59,402 | Grant | Trans-NIH Recovery Act Research Support: Malaria and other human diseases caused by mosquito-borne pathogens are major threats to global health. The spread of insecticide-resistant mosquitoes, drug-resistant parasites and the lack of effective or affordable vaccines have all led to an alarming i | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| NORTH CAROLINA STATE UNIVERSITY | $161,470 | Grant | Trans-NIH Recovery Act Research Support: This improvement request involves animal facility equipment purchase for the North Carolina State University (NCSU) College of Veterinary Medicine (CVM), specifically, individually ventilated cage systems for mice, and support equipment, for use in the th | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| YALE UNIVERSITY | $824,822 | Grant | Trans-NIH Recovery Act Research Support: Mice with a null mutation of the homeobox gene Hhex die mid-gestation with multiple developmental defects, including complete absence of the liver. Recently, we derived two strains of mice with a deletion of Hhex in the developing liver - at E9.0 in the l | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| YALE UNIVERSITY | $827,500 | Grant | Trans-NIH Recovery Act Research Support: Preeclampsia and intrauterine growth restriction are serious complications of pregnancy that endanger maternal and fetal health. Its most severe cases are associated with a fetal mortality of 50%. In this application we propose to study the mechanism of p | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| UNIVERSITY OF TENNESSEE | $723,662 | Grant | Trans-NIH Recovery Act Research Support: Individuals born small for gestational age have increased risks of serious illness as newborns and throughout life, including hypertension, cardiovascular disease, type 2 diabetes and pregnancy-related hypertension and diabetes. Both traditional genetics | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| WAKE FOREST UNIVERSITY | $654,195 | Grant | Trans-NIH Recovery Act Research Support: Description of Overall Purpose-The long-term goal of the proposed research is to further develop and understand the nitric oxide (NO) and nitroxyl (HNO), the one-electron reduced form of NO, producing reactions of C-nitroso compounds (1, Scheme 1). Some | Health and Human Services, Department of / National Institutes of Health | 6/16/2009 |
| UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC. | $708,409 | Grant | Trans-NIH Recovery Act Research Support: The 90 kDa heat shock proteins are proving to be extraordinary cancer chemotherapeutic targets as evidenced by the fact that more than 20 clinical trials are currently in progress. Unfortunately, all of these trials are based upon N-terminal inhibitors, | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| DUKE UNIVERSITY | $4,213,882 | Grant | National Center for Research Resources, Recovery Act Construction Support: The long-term objective of the proposed project is to create a unique, state-of-the-art facility for bioengineering and biomedical research within the Fitzpatrick Center for Interdisciplinary Engineering, Medicine and Applied d Sciences (CIEMAS). This facil... Show more | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $2,310,000 | Grant | Trans-NIH Recovery Act Research Support: Mammalian genomes have a complex physical structure shaped by myriad duplications, deletions and rearrangements, and this structure varies considerably among the populations and individuals of a species. These 'structural variations' are of special import | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $2,413,250 | Grant | Trans-NIH Recovery Act Research Support: The overall aims of this project are to explore the effects of multiple levels of racism on the immune function, and overall health of urban African Americans, and to test a novel structural-level intervention to reduce the negative impact of racism. Sign | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| WASHINGTON UNIVERSITY, THE | $55,811 | Grant | Trans-NIH Recovery Act Research Support: Osteoporosis, resulting from increased bone resorption relative to formation, affects millions of Americans and its prevalence is increasing with the aging population. It is estimated that half of all women over the age of 50 will have an osteoporosis-rel | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $82,556 | Grant | Trans-NIH Recovery Act Research Support: Age-related cognitive decline has been documented across many species including rodents, non-human primates, and humans. Normal cognitive aging, while accompanied by structural preservation of the brain, represents a significant compromise of the dynamic | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| PONCE MEDICAL SCHOOL FOUNDATION INC | $55,356 | Grant | Trans-NIH Recovery Act Research Support: Globally, a large majority of HIV-1 infection in women occurs through heterosexual transmission (HST). HST transpires when semen (considered as the principal source for both cell-free (cf) and cell-associated (ca) virus) from an infected male interacts wi | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $76,211 | Grant | Trans-NIH Recovery Act Research Support: Articular cartilage damage is a growing problem with active and increasingly aging populations. Cartilage, which is critical for frictionless and painless joint motion, has little endogenous repair capability. Aging processes and trauma lead to cartilage | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF MARYLAND | $27,252 | Grant | Trans-NIH Recovery Act Research Support: Neisseria gonorrhoeae is the causative agent of gonorrhea; humans are their only natural host. Neisseria can disseminate from mucosal surfaces to cause severe diseases. Sexually transmitted infections, including gonorrhea, cause substantial morbidity in | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON | $56,316 | Grant | Trans-NIH Recovery Act Research Support: The objective of the proposed project is to evaluate the cellular immune response to Rift Valley fever virus (RVFV) wild-type (ZH501) and vaccine strain (MP-12) infections. There is very little published data pertaining to the effect of RVFV infection on | Health and Human Services, Department of / National Institutes of Health | 7/30/2009 |
| VIRGINIA COMMONWEALTH UNIVERSITY | $30,395 | Grant | Trans-NIH Recovery Act Research Support: Pruritus is the clinical term for itch, an unpleasant nocifensive sensation that results in the desire to scratch the affected area. Pruritus can greatly reduce the quality of life of those inflicted, and further consequences of pruritus can include scrat | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $31,851 | Grant | Trans-NIH Recovery Act Research Support: Temporomandibular joint disorders (TMJD), including osteoarthritis and internal derangement, have a high prevalence in the adult population and often cause pain and limited jaw function. Severe deterioration of the articular cartilage of the mandibular co | Health and Human Services, Department of / National Institutes of Health | 5/01/2009 |
| ST. JUDE CHILDREN'S RESEARCH HOSPITAL | $102,208 | Grant | Trans-NIH Recovery Act Research Support: Streptococcus pneumoniae is a major cause of morbidity and mortality worldwide. The pneumococcus is able to colonize and replicate in a number of sites in the human host including the nasopharynx (colonization), lungs (pneumoniae), blood (sepsis, and the | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $17,993 | Grant | Trans-NIH Recovery Act Research Support: NLR Regulation of Innate Immune Responses to Respiratory Virus Infection Project Summary/Purpose: Innate immune responses to viruses and other pathogens typically involve a highly conserved host-cell signaling mechanism designed to protect and rid the hos | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $97,684 | Grant | Trans-NIH Recovery Act Research Support: The goals of this study are two-fold: 1) to understand how energy-dependent ATPase enzymes function in bacterial secretion and 2) to elucidate mechanisms of ATPase regulation by accessory proteins. This application will focus on characterizing the biochem | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $47,210 | Grant | Trans-NIH Recovery Act Research Support: Both U.S. licensed influenza vaccines provide little heterosubtypic protection, and thus, must be reformulated annually in an attempt to match the vaccine strains with those circulating in subsequent epidemics. Thus, an ideal influenza vaccine adjuvant wo | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| GEORGETOWN UNIVERSITY (THE) | $499,538 | Grant | Trans-NIH Recovery Act Research Support: The general objective of this project is to provide support and care for the use of pathogen free and genetically modified mice at Georgetown University. This grant will purchase ventilated racks, perform minor renovations and install a wireless rack ala | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| COLORADO STATE UNIVERSITY | $478,393 | Grant | Trans-NIH Recovery Act Research Support: This proposal outlines a plan for capacity building at the Rocky Mountain Regional Biocontainment Laboratory (RMRBL) at Colorado State University. The RMRBL is one component of the CSU Foothills Campus Infectious Disease Research Center (IDRC). By 2010, t | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $254,635 | Grant | Trans-NIH Recovery Act Research Support: Preliminary Effectiveness Analysis of Universal Rotavirus Immunization, Nicaragua The goal of the study is to measure the effectiveness of a universal rotavirus vaccine immunization program in reducing diarrhea in a developing world setting (Nicaragua). | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| NORTHWESTERN UNIVERSITY | $1,597,119 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to identify functional variants of environmentally responsive genes that are biologically relevant to motor neuron degeneration of sporadic amyotrophic lateral sclerosis (SALS) and primary lateral sclerosis (PLS). Considerable | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $924,000 | Grant | Trans-NIH Recovery Act Research Support: The following grant application is submitted in response to RFA-OD-09-005 (Recovery Act Limited Competition: Supporting New Faculty Recruitment to Enhance Research Resources through Biomedical Research Core Centers [P30]). We believe that the application | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $765,713 | Grant | Trans-NIH Recovery Act Research Support: To hire an indentified faculty candidate who will join an interactive and multidisciplinary group of researchers at MUSC who are currently investigating the plasticity of ascohol addiction and dependence. The proposed new faculty hire will augment and ex | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $809,846 | Grant | Trans-NIH Recovery Act Research Support: This P30 proposal is in response to RFA-OD-09-005 and has the goal of hiring an early stage investigator with a strong record of research productivity and interests and expertise in alcohol research of a developmental nature as a tenure-track, assistant p | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $885,937 | Grant | Trans-NIH Recovery Act Research Support: The loss of cognitive function with normal aging is well known and while clearly different from the catastrophic loss of memory seen in Alzheimer's disease and the other age-related dementias, is of concern to an increasing number of Americans. This appli | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $780,298 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this proposal is to recruit two faculty members to the Musculoskeletal Research Consortium program at the University of Michigan. The new faculty will be part of an innovative multidisciplinary program focused on the interface between tendo | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $1,303,696 | Grant | Trans-NIH Recovery Act Research Support: The UAB Comprehensive Cancer Center is the hub for cancer research activities at UAB and requests funding from the NCI through this mechanism to facilitate recruitment of two early stage investigators as part of the Center's membership. In particular we a | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF WASHINGTON | $1,460,849 | Grant | Trans-NIH Recovery Act Research Support: The major goal of the Division of Hematology at the University of Washington is to recruit and support physician/scientists to facilitate our mission of bi-directional translational research. Dr. Eli Estey, Professor of Medicine/Hematology, has organized | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $1,570,000 | Grant | Trans-NIH Recovery Act Research Support: This award is for the recruitment of junior faculty who will be involved in melanoma research and will serve to expand an initiative in melanoma disase focused basic and translational research at Case Comprehensive Cancer Center. Funds will support their | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UMDNJ-ROBERT WOOD JOHNSON MEDICAL SCHOOL | $1,467,806 | Grant | Trans-NIH Recovery Act Research Support: A critical enhancement to the Core Center for Systems Biology and Cancer at the Cancer Institute of New Jersey funded by this proposal will be a New Investigator who is an experimentalist with experience in uncovering the biological consequences of geneti | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| DUKE UNIVERSITY | $1,378,000 | Grant | Trans-NIH Recovery Act Research Support: The nascent interdisciplinary field of Neuroeconomics harnesses the computational rigor of economics and the technological advances of modern biology to advance discovery in the decision sciences. Since pathologies of decision making are endemic to addict | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| PURDUE UNIVERSITY | $884,854 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION: Increasing evidence suggests that disturbances in attention and working memory may contribute to the development of specific language impairment (SLI) and stuttering. However, how a detriment in these functions interacts with both linguistic | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $682,979 | Grant | Trans-NIH Recovery Act Research Support: The Department of Physiology and Membrane Biology is applying for P30 funds to recruit new faculty with research focus and demonstrated achievement in the areas of membrane transporter, channel or receptor structure function analysis and or modern proteom | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| WASHINGTON UNIVERSITY, THE | $1,113,347 | Grant | Trans-NIH Recovery Act Research Support: This application seeks support from the National Heart, Lung & Blood Institute (NHLBI) through the NIH P30 mechanism (OD-09-005) for resources to recruit a newly independent assistant professor to the Diabetic Cardiovascular Disease Center (DCDC) at Washi | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF MIAMI | $985,620 | Grant | Trans-NIH Recovery Act Research Support: This award is being used for a physician-scientist, who joined the faculty on July 1, 2010 to expand the focus of the laboratories of airway biology within the Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine at the University of Miami Mi | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | $1,237,825 | Grant | Trans-NIH Recovery Act Research Support: The goal of this proposal is to provide funds for start-up packages for two new, independent tenure-track faculty members in the Department of Neurobiology and Behavior at SUNY Stony Brook. Support would be utilized to revitalize the faculty searches stal | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $1,325,612 | Grant | Trans-NIH Recovery Act Research Support: These are exciting yet challenging times for Dartmouth Medical School (DMS), as we strive to recruit and nurture junior-level faculty to thrive in and perpetuate Dartmouth's rich tradition of excellence in biomedical research and education. The financial | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF PITTSBURGH THE | $1,201,412 | Grant | Trans-NIH Recovery Act Research Support: The Aim of the Program Plan that is the basis of this application is to expand the breadth of research expertise and research programs in the Center for Pain Research at the University of Pittsburgh. Center faculty members have identified two broad areas | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| BRANDEIS UNIVERSITY | $870,812 | Grant | Trans-NIH Recovery Act Research Support: Brandeis University is home to 22 neuroscience research laboratories and is a rich and collaborative environment for neuroscience research. However, a gap exists between cellular and molecular neuroscientists using mainly in vitro techniques, and the syst | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $998,808 | Grant | Trans-NIH Recovery Act Research Support: Impact: This P30 will unfreeze a new faculty recruitment to enhance resources through a Biomedical Research Core Center in Neural Engineering at Penn State University. The impact will be the ability to hire a powerful and unique candidate in a multidiscip | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| THOMAS JEFFERSON UNIVERSITY | $1,418,884 | Grant | Trans-NIH Recovery Act Research Support: Preliminary data on proteins secreted by adipose tissue in the obese with high BP (OHBP) and obese with normal BP (ONBP) indicate a pro-inflammatory profile in OHBP (lower adiponectin, higher interleukin 6, higher plasminogen activator inhibitor-1) compar | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $846,667 | Grant | Trans-NIH Recovery Act Research Support: Potential method to reduce alcohol-related problems, including various types of crime, is to decrease overall drinking rates by changing environmental factors such as the availability of alcohol. Our goal is to evaluate whether density of alcohol establis | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $734,819 | Grant | Trans-NIH Recovery Act Research Support: Alcoholic liver disease affects more than 2.5 million people and costs in excess of $1.5 billion/year for treatment and lost productivity in the U.S.. Alcohol use remains the most common cause of liver-related mortality. Worldwide, alcoholic liver disease | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY OF MARYLAND | $753,174 | Grant | Trans-NIH Recovery Act Research Support: Alcoholism and anxiety frequently co-occur in humans; however, it has been difficult to find a single treatment which is effective against both conditions. Substantial evidence suggests that the motivational aspects of alcohol withdrawal (e.g., increased | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $759,600 | Grant | Trans-NIH Recovery Act Research Support: The long-term scientific purpose the study is to develop risk-markers for individual susceptibility to alcoholism using brainwave measures. The proposal is derived from the PI's previous event-related brain potential (ERP) studies of familial alcoholism a | Health and Human Services, Department of / National Institutes of Health | 5/22/2009 |
| UNIVERSITY OF PITTSBURGH THE | $1,691,538 | Grant | Trans-NIH Recovery Act Research Support: Despite our ability to identify risk factors that may increase the likelihood of acquiring Alzheimer's (such as age, family history, and some possible genetic markers), we cannot identify with certainty those who will develop this disease. A research grou | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC. | $746,500 | Grant | Trans-NIH Recovery Act Research Support: Elderly patients who suffer traumatic brain injury (TBI) have increased mortality and survivors have a poorer prognosis than young or middle aged adults who suffer comparable injuries. We have demonstrated that the aging brain is in a hyperinflammatory st | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF CONNECTICUT | $746,163 | Grant | Trans-NIH Recovery Act Research Support: The proposed studies of this application will explore the essential process of accurate transcription initiation in trypanosomatid parasites which cause major human diseases. The proteins involved in this process exhibit an unprecedented divergence level | Health and Human Services, Department of / National Institutes of Health | 5/12/2009 |
| UNIVERSITY OF ROCHESTER | $760,624 | Grant | Trans-NIH Recovery Act Research Support: Streptococcus pneumoniae (S.p.), an important human pathogen causing pneumonia, is a major cause of morbidity and mortality worldwide. Its early mortality rate still remains the highest when compared to the pre-antibiotic era. Pneumolysin (PLY), a key cyt | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $949,500 | Grant | Trans-NIH Recovery Act Research Support: This project is to define the defect in T cell positive selection Themis (previously known as MG143) knockout mice in terms of signaling pathways that are affected, the interactions with other members of the TCR-signaling cascade, and changes in gene expr | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| CORNELL UNIVERSITY, INC | $455,034 | Grant | Trans-NIH Recovery Act Research Support: Multidrug resistant (MDR) tuberculosis (TB) is recognized as an emerging infectious disease and a major problem in global public health. MDR M. tuberculosis is also classified as a Category C Priority Pathogen for biodefense research. The threat of MDR a | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| VACCINE RESEARCH INSTITUTE OF SAN DIEGO | $927,762 | Grant | Trans-NIH Recovery Act Research Support: Research Grant entitled 'Salmonella Genes Associated with Colonization of Specific Hosts'. The purpose of this research is to identify salmonella genes responsible for the colonization of specific host species. | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $888,750 | Grant | Trans-NIH Recovery Act Research Support: Pathogens have developed sophisticated mechanisms to enter cells, evade destruction inside the eukaryotic cell and multiply. The cytoskeleton of the host cell is a common target that is manipulated by bacteria to facilitate infection. Invasive bacteria co | Health and Human Services, Department of / National Institutes of Health | 7/23/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $400,750 | Grant | Trans-NIH Recovery Act Research Support: Defects in the appropriate regulation of T cell function and homeostasis are fundamental to the pathogenesis of Systemic Lupus Erythematosus (SLE). Classically, SLE exhibits a striking gender bias and preferentially affects women. Although sex hormones, i | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| UNIVERSITY OF IOWA, THE | $750,000 | Grant | Trans-NIH Recovery Act Research Support: The magnitude and the duration of cytokine action are essential in determining the response to foreign antigens and allergens. Thus, the action of cytokines is tightly regulated both developmentally and within the cell. The Suppressor of Cytokine Signalin | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $741,172 | Grant | Trans-NIH Recovery Act Research Support: The goal of this proposal is to elucidate the molecular mechanisms that control lineage-specific expression or repression of the Ifng locus as a model for understanding factors regulating effector T cell lineage specification. Th1, Th2, and Th17 cells, t | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $740,796 | Grant | Trans-NIH Recovery Act Research Support: The envelope of Gram-negative bacteria consists of two membranes separated by the periplasmic compartment that contains the peptidoglycan wall. The inner membrane (IM) is in contact with the cytosol while the outer membrane (OM) contacts the extracellular | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $1,074,503 | Grant | Trans-NIH Recovery Act Research Support: Rare diseases are studied in isolated laboratories, forgotten by main stream pharmacological companies, and considered almost academic curiosities. Finding variables that correlate/cause rare diseases (a condition is rare when it affects less than 1 perso | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $693,000 | Grant | Trans-NIH Recovery Act Research Support: Cyclic AMP (cAMP), the prototypical second messenger, regulates a wide variety of cellular processes. In the nervous system, cAMP has a role in many of the medium- to long-term changes that occur in neurons, and that we associate with higher-order functio | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | $1,151,368 | Grant | Trans-NIH Recovery Act Research Support: Sensory information reaching the brain is processed by region-restricted neural networks leading to learning and adaptation to a constantly changing environment. Recent studies have elucidated some of the general molecular mechanisms underlying learning a | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| EMORY UNIVERSITY | $3,148,467 | Grant | Trans-NIH Recovery Act Research Support: Epigenetic Marks as Peripheral Biomarkers of Autism Autism spectrum disorders (ASD) are a common phenotype with a complex etiology. While a rare single gene or genomic interval may be sufficient to lead to ASD, most patients likely owe their disease to a | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF WASHINGTON | $132,600 | Grant | Trans-NIH Recovery Act Research Support: Studies of familial Alzheimer's disease (AD) have revealed three important AD genes, Amyloid Precursor Protein (APP), Presenilin 1 PS1) and Presenilin 2 (PS2), in which mutations lead to autosomal dominant AD with nearly complete penetrance. Recent litera | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| RAND CORPORATION. THE | $157,539 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This project aims to build on the existing retirement literature within economics by using a unique combination of administrative data, quasi-experimental variation and structural estimation to analyze the labor supply | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON | $151,000 | Grant | Trans-NIH Recovery Act Research Support: Burkholderia (B.) mallei is a highly evolved Gram-negative bacterium that primarily infects solipeds but it is transmissible to humans by ingestion, cutaneous or aerosol exposures. Concern over this bacterium and the very closely related species B. pseudo | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $418,859 | Grant | Trans-NIH Recovery Act Research Support: Fetal alcohol exposure in humans is recognized as a likely contributor to alcohol abuse during adolescence and adulthood. Exposure to ethanol in laboratory rodents during the first two postnatal weeks is widely used as an experimental model of human fetal | Health and Human Services, Department of / National Institutes of Health | 6/09/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $346,500 | Grant | Trans-NIH Recovery Act Research Support: The pilot research project will examine the empirical validity of key assumptions regarding the epidemiology of adolescent alcohol use that underlie current federal and state policies toward community- based prevention of alcohol use and other problem beh | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| LOYOLA UNIVERSITY | $411,125 | Grant | Trans-NIH Recovery Act Research Support: Women who abuse alcohol are twice as likely to develop anxiety disorders compared with men, a phenomenon in which the underlying biological mechanisms are unknown. Our overall objective is to identify the interactive effects of alcohol and estrogen on ar | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $333,742 | Grant | Trans-NIH Recovery Act Research Support: A Feasibility Study to Improve Older Patient - Physician Communication The purpose of this study is to evaluate the feasibility of implementing a novel health information technology during routine outpatient encounters between physicians and older patient | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION | $327,712 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this project is to conduct a longitudinal investigation of the incidence of medically serious (sentinel) adverse medical events among older adults and to examine subsequent patterns of health, healthcare service use, and costs over sev | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $319,843 | Grant | Trans-NIH Recovery Act Research Support: The focus of this project is to develop the formative structures and processes needed to test the efficacy of hand feeding versus tube feeding in persons with late-stage dementia through a larger randomized controlled R01 study. Feeding among persons with | Health and Human Services, Department of / National Institutes of Health | 5/20/2009 |
| WAKE FOREST UNIVERSITY | $333,741 | Grant | Trans-NIH Recovery Act Research Support: This research seeks to determine the role extracellular matrix (ECM) plays in the aging of skeletal muscle. The loss of skeletal muscle mass and strength that occurs during the aging process represents a major health issue facing a growing elderly populat | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $334,150 | Grant | Trans-NIH Recovery Act Research Support: We propose this exploratory project to investigate the underlying mechanism of osteoporotic vertebral fracture that is frequently observed in postmenopausal women. Osteoporosis is a metabolic bone disorder, predominantly prevalent in the elderly populatio | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $488,922 | Grant | Trans-NIH Recovery Act Research Support: There is a need to quantify cellular turnover in the context of aging. We will establish the foundations of a new method to contribute crucial information to fulfill this need. This method will permit to track stable-isotope labeled cells and to measure t | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| CHILDRENS HOSPITAL OF PHILADELPHIA | $452,375 | Grant | Trans-NIH Recovery Act Research Support: Foxp3, a 47-kDa transcription factor, is necessary and sufficient for development and function of natural Tregs. The role of Foxp3+ Tregs in controlling self-reactive T cells and preventing autoimmunity is well established. During comparison of Foxp3 expr | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $184,810 | Grant | Trans-NIH Recovery Act Research Support: The Department of Medical Informatics & Clinical Epidemiology (DMICE) of Oregon Health & Science University (OHSU) is pleased to submit a competitive continuation for its National Library of Medicine (NLM) fellowship training program for a fourth five-yea | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| UNIVERSITY AUXILIARY AND RESEARCH SERVICES CORPORATION | $294,797 | Grant | Trans-NIH Recovery Act Research Support: Project Summary/Abstract for more than 30 years, there has been a nationwide effort to encourage students from underrepresented ethnic minorities to pursue careers I nthe sciences. Despite widespread intervention programs, there remains a significant une | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| TRUSTEES OF PRINCETON UNIVERSITY, THE | $199,965 | Grant | Trans-NIH Recovery Act Research Support: Large-scale protein interaction networks have been determined experimentally for several organisms, and computational analysis of these networks provides new opportunities to uncover protein functions and pathways. At the same time, despite improvements i | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| NORTHWESTERN UNIVERSITY | $119,004 | Grant | Trans-NIH Recovery Act Research Support: The ability of individual cells to adhere and differentiate into distinct tissues is a major feature of multicellular organisms. The cadherin/catenin adhesion signaling system plays a central role in coordinating cell-cell adhesion and differentiation, as | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF HAWAII SYSTEMS | $98,000 | Grant | Trans-NIH Recovery Act Research Support: The proposed research will investigate the interaction of a protein called dynamin, specifically mutant forms of dynamin, that are implicated in a disease known as Charcot-Marie-Tooth syndrome. The proposed studies will track the movement of these protein | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $997,723 | Grant | Trans-NIH Recovery Act Research Support: HIV-caused AIDS is a potentially lethal disease with no vaccine or cure available at the moment. The obstacles to overcome when developing an effective HIV vaccine include devising a strategy that would generate cellular and humoral immunity with sufficie | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| TITAN PHARMACEUTICALS, INC. | $7,586,848 | Grant | Trans-NIH Recovery Act Research Support: Project Title: A Six-Month, RCT of Probuphine Safety and Efficacy in Opioid Addiction. We are conducting a six-month, randomized, placebo and active-controlled, multicenter clinical trial of Probuphine in patients with opioid dependence for the purpose | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF PRINCETON UNIVERSITY, THE | $66,152 | Grant | Trans-NIH Recovery Act Research Support: Embryonic cells use the Hedgehog signaling pathway to convey information that controls cell fate, proliferation, and survival. Misregulation of this pathway leads to birth defects and a variety of cancers in humans. Recent data point to key mechanisms con | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $216,757 | Grant | Trans-NIH Recovery Act Research Support: Executive functioning (EF) refers to self-regulation of thought and behavior. It has been implicated in several areas of cognitive and social development and deficits in EF are found in childhood disorders of autism and ADHD. Surprisingly little is known, | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $63,950 | Grant | Trans-NIH Recovery Act Research Support: We received notification of our grant award (grant # 3R01HD052074-03S1) on September 17, 2009. Since then we have contacted a sales representatives from Thermo Fisher Scientific, Nanodrop Products regarding the Nanodrop 2000 spectrophotometer. We have sig | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| CARNEGIE INSTITUTION OF WASHINGTON | $37,253 | Grant | Trans-NIH Recovery Act Research Support: The Award was a Summer Supplement to the NIH Parent Grant 2RO1HD042215-06, Left-Right Asymmetry of the Developing Diecephalon under direction of Dr. Marnie Halpern | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $87,714 | Grant | Trans-NIH Recovery Act Research Support: We received notification of our grant award (grant # 3R01HD046589-04S1) on September 22, 2009. Tissue for the two microarray projects have been isolated and shipped to Genome Explorations, Inc. in Memphis, TN on December 9, 2009 for processing. The first | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $194,788 | Grant | Trans-NIH Recovery Act Research Support: Current nutritional strategies for very preterm infants in this country are resulting in postnatal growth failure from which the neonate does not recover by the time of hospital discharge. Undernutrition, particularly insufficient protein intake during cr | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $80,835 | Grant | Trans-NIH Recovery Act Research Support: Fetal growth restriction (FGR) increases the already substantial risk of prematurity for infants' survival, overall function and later learning competence. Of the 12% of prematurely born infants in the US each year, more than 5% failed to grow appropriate | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $271,198 | Grant | Trans-NIH Recovery Act Research Support: Traumatic brain injury (TBI) is a significant public health problem, with 1.5-2.0 million Americans injured each year. Cognitive deficits, particularly in the domains of memory and attention are frequently the source of lingering disability after TBI and | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF FLORIDA | $138,436 | Grant | Trans-NIH Recovery Act Research Support: Muscle atrophy and weakness secondary to disuse are common clinical phenomena, which can significantly impact activities of daily living and present a major challenge in rehabilitation. Rehabilitation programs designed to maximize strength gains may not b | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $471,683 | Grant | Trans-NIH Recovery Act Research Support: The impact that drug addictions have on health disparities impacting at-risk African Americans who reside in the rural South are grossly understudied. While there is strong evidence linking drug use and abuse to violent behaviors, injuries, mental health, | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF ROCHESTER | $308,000 | Grant | Trans-NIH Recovery Act Research Support: Otitis media (OM) is the most common childhood bacterial infection and also the leading cause of conductive hearing loss in children. Inflammation in the middle ear caused by microorganisms is a hallmark of OM. Nontypeable Haemophilus influenzae (NTHi) is | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| UNIVERSITY OF WASHINGTON | $1,086,653 | Grant | Trans-NIH Recovery Act Research Support: This proposal focuses on the design and development of a scalable PET detector with depth-of-interaction (DOI) positioning capability. The basic module design will be suitable for high resolution, small animal PET imaging and clinical, time-of-flight (TO | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| J CRAIG VENTER INSTITUTE INC | $1,107,729 | Grant | Trans-NIH Recovery Act Research Support: Invasive aspergillosis caused primarily by Aspergillus fumigates is an emerging source of morbidity and mortality in developed countries including the U.S. Despite the accumulating evidence of the medical significance of this common mold, our understandi | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF CHICAGO, THE | $780,000 | Grant | Trans-NIH Recovery Act Research Support: Tolerance to allogeneic grafts can be achieved in a number of rodent models, and long-term graft survival has been reported in a number of non-human primate models. A consistent feature of stable graft acceptance is the control of alloantibody production; | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $1,036,524 | Grant | Trans-NIH Recovery Act Research Support: An urgent need exists to prevent the sexual transmission of HIV-1 to women. Although infection rates exceed 35% in parts of sub-Saharan Africa, very little attention is devoted to the role of the female reproductive tract (FRT) in preventing viral transmi | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | $602,271 | Grant | Trans-NIH Recovery Act Research Support: The association of Clq with autoimmune diseases in genera!, and with systemic lupus erythematosus (SLE) in particular, has been firmly established. Genetic deficiency of Clq is in 3L? fact considered to be a strong susceptibility factor for SLE. Of the kn | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| NEW YORK UNIVERSITY (INC) | $845,104 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): CD4 T cells are an essential component of the immune responses against HIV and other virus, but CD4 T cells are the prime targets for HIV infection. Hence, there are concerns that HIV vaccines which stimulate and expa | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| UNIVERSITY OF MARYLAND | $850,866 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this project is to identify novel monoclonal antibodies (mAbs) that broadly recognize the HIV-1 envelope glycoprotein (Env) and block infection in vitro to guide vaccine development. This goal will be pursued in a cohort of HIV-1 inf | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| UNIVERSITY OF MARYLAND | $750,000 | Grant | Trans-NIH Recovery Act Research Support: Pathogenic bacteria require iron for their survival and ability to cause infection. Heme comprises 90% of the iron available within the host and plays a significant role in the colonization and virulence of many bacterial pathogens. Shigella spp. and ente | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $510,450 | Grant | Trans-NIH Recovery Act Research Support: A mechanistic understanding of cancer rests heavily upon the mutated genes. Mutated genes include the dominant oncogenes and recessive suppressor genes that are mutated somatically to drive tumorigenesis. Pancreatic cancer has historically been an unusual | Health and Human Services, Department of / National Institutes of Health | 5/13/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $937,439 | Grant | Trans-NIH Recovery Act Research Support: Melanoma, the most virulent form of skin cancer, is not responsive to chemotherapy. This project proposes to develop a method to sensitize melanomas to chemotherapy by selectively acidifying the cancer cells whileminimally affecting normal cells. The meth | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $665,561 | Grant | Trans-NIH Recovery Act Research Support: The selective expression of vascular endothelial growth factor (VEGF) receptors on surface of tumor vessel endothelial cells (ECs) is an attractive target for radiotherapy. We propose to use a genetically engineered form of VEGF-A (VEGF121) labeled for VE | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $1,362,331 | Grant | Trans-NIH Recovery Act Research Support: In this proposal, we build upon an epidemiologic risk model for lung cancer that we recently developed from a lung cancer case-control study of 1851 Caucasian lung cancer patients and 2001 controls, matched to the cases on sex, age (15 years), smoking sta | Health and Human Services, Department of / National Institutes of Health | 8/12/2009 |
| UNIVERSITY OF PITTSBURGH THE | $565,851 | Grant | Trans-NIH Recovery Act Research Support: We previously discovered that a protein called CYP24 is over-produced in lung cancer. The purpose of this award is to determine the role of CYP24 in stimulating the development and/or growth of lung tumors. CYP24 degrades the natural anti-tumor agent, 1,2 | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $326,431 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Radioresistance markedly impairs the efficacy of radiotherapy and involves cell signal transduction pathways that prevent radiation-induced cell death. Proteins in the Bcl-2 family are central and dual regulators of ap | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $4,309,389 | Grant | Trans-NIH Recovery Act Research Support: We propose to conduct a genome-wide association study to identify loci involved in endometrial cancer causation. We plan to utilize studies with available biospecimens, 6 cohorts from the NCI Cohort Consortium and 7 case-control studies, within the NCI Ep | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $853,079 | Grant | Trans-NIH Recovery Act Research Support: Our overarching goals are to design better therapies for the treatment of brain tumors. Medulloblastoma, a pediatric malignancy of the cerebellum with the highest incidence of all pediatric brain tumors, and glioma, themost malignant and invasive adult br | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $591,082 | Grant | Trans-NIH Recovery Act Research Support: In contrast to the well studied role of intrinsic factors in tumorigenesis, knowledge regarding the mechanism(s) whereby extrinsic factors, such as the stromal/matrix microenvironment, influence an initiated cell with permanent genetic alterations to tran | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| LOYOLA UNIVERSITY | $310,213 | Grant | Trans-NIH Recovery Act Research Support: Ultraviolet (UV) radiation represents a definitive risk factor for skin cancer, particularly in combination with certain underlying genetic traits, such as red hair and fair skin. Skin pigmentation results from the synthesis of melanin in pigment-producin | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| SAN DIEGO STATE UNIVERSITY FOUNDATION | $643,173 | Grant | Trans-NIH Recovery Act Research Support: The sansalvamide A (San A) scaffold is a promising structure for the development of novel cancer therapeutics. We have used the San A scaffold to produce 7 compounds that are cytotoxic to pancreatic and colon cancer cell lines at nanomolar concentrations. | Health and Human Services, Department of / National Institutes of Health | 5/24/2009 |
| MAYO CLINIC | $1,085,473 | Grant | Trans-NIH Recovery Act Research Support: Cigarette smoking is the single most important preventable cause of morbidity, mortality and excess health care costs in the United States and accounts for 30% of U.S. cancer deaths. Varenicline and bupropion SR (sustained-release) are non nicotine pharma | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| DUKE UNIVERSITY | $633,697 | Grant | Trans-NIH Recovery Act Research Support: 1. Instrument development: We will design and implement new coherence imaging instrumentation to enable examination of colorectal tissues for ex vivo studies. For the a/LCI surveillance studies, we will develop new fiber optic probe designs suitable for | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| THE GEORGE WASHINGTON UNIVERSITY | $649,476 | Grant | Trans-NIH Recovery Act Research Support: Specific Aims are to determine: (1) The mechanistic basis of Pak1 stimulation by DSB damage and role of Pak1 in DSB signaling in breast cancer cells; (2) The molecular basis and significance of MORC2G??s contribution in DNA damage response | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $680,600 | Grant | Trans-NIH Recovery Act Research Support: The Role of MicroRNA Alterations in Barrett?s Carcinogenesis: Patients with Barrett?s esophagus (BE) are at increased risk of developing esophageal adenocarcinoma (EAC), one of the most rapidly increasing cancers in developed nations. The molecular geneti | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| TANGLEWOOD RESEARCH INC | $1,176,751 | Grant | Trans-NIH Recovery Act Research Support: The intent of this research is to gain knowledge about how to maximize drug use prevention effectiveness under real-world conditions. This research will address the question: 'What can be done to make prevention programs more effective once they are disse | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| MARQUETTE UNIVERSITY | $1,433,992 | Grant | Trans-NIH Recovery Act Research Support: Addiction to cocaine and other illicit drugs is estimated to cost our society $181 billion which equates to $603 per U.S. citizen. The cost of addiction can be dramatically lowered through the use of treatments; unfortunately, many drugs of abuse, includi | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| WAYNE STATE UNIVERSITY (INC) | $1,353,500 | Grant | Trans-NIH Recovery Act Research Support: To determine in a laboratory model of CM, using money as a non-drug alternative, whether: a) higher vs. lower magnitude continuous positive reinforcement increases cocaine elasticity; b) intermittent positive reinforcement conditions differentially affect | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF KENTUCKY | $684,807 | Grant | Trans-NIH Recovery Act Research Support: Opioid abuse and dependence are growing public health problems in the United States. While rates of heroin use have remained fairly stable over the past several years, abuse and dependence on prescription opioids have shown sharp increases over the past d | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $837,595 | Grant | Trans-NIH Recovery Act Research Support: The human sweet receptor, composed of the monomers T1R2 + T1R3, appears to be the main (and perhaps the only) receptor underlying sweet taste in humans. When co-expressed with a reporter G-protein in heterologous systems, this heterodimeric receptor respo | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| JOHN B. PIERCE LABORATORY, INC., THE | $711,110 | Grant | Trans-NIH Recovery Act Research Support: How multimodal stimuli become integrated is a fundamental question in neuroscience. This question is particularly relevant to flavor perception, in which simultaneous stimulation of touch, temperature, taste and olfaction invariably occurs during ingestio | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| UNIVERSITY OF ILLINOIS | $908,140 | Grant | Trans-NIH Recovery Act Research Support: Dental progenitor cells are a unique stem cell resource for tissue repair and regeneration because of their accessibility and because of the autologous potential of tissues derived from third molar teeth. The current proposal is based on the hypothesis t | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $790,654 | Grant | Trans-NIH Recovery Act Research Support: It is the long-term objective of this study to understand the genetic control of root development and periodontium formation. Advances in molecular and developmental biology have linked the function of numerous genes to specific stages of organ developmen | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| WAYNE STATE UNIVERSITY (INC) | $582,416 | Grant | Trans-NIH Recovery Act Research Support: Our general goal is to determine the temporal and spatial interactions among lipolytic proteins in adipocytes and myocytes. The goal will be accomplished by 2 specific aims: 1. To test specific mechanisms of lipase, co-activator and scaffold interactions | Health and Human Services, Department of / National Institutes of Health | 5/26/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $732,959 | Grant | Trans-NIH Recovery Act Research Support: Autosomal dominant polycystic kidney disease (ADPKD) is largely caused by mutations in the PKD1 and PKD2 genes, encoding the polycystins 1 (PC1) and 2 (PC2) proteins. The pathogenesis of ADPKD entails dysfunctional ion transport and/or regulatory mechanis | Health and Human Services, Department of / National Institutes of Health | 6/30/2009 |
| UNIVERSITY OF OKLAHOMA | $1,378,367 | Grant | Trans-NIH Recovery Act Research Support: Micro- and macrovascular disease are major causes of morbidity and premature mortality in diabetes mellitus. Our underlying hypothesis is that vascular damage is promoted by the inter-related proceses of dyslipoproteinemia, inflammation, and oxidative str | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | $1,370,948 | Grant | Trans-NIH Recovery Act Research Support: he overall goal of this project is to determine the role of oxidative stress with associated inflammation and abnormalities in nitric oxide synthase (NOS) in the pathogenesis of clinical cardiovascular disease (CVD), carotid IMT, cardiac MRI and microvasc | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY OF MARYLAND | $675,000 | Grant | Trans-NIH Recovery Act Research Support: The serine proteases are the pivotal regulators of a variety of cellular processes critical for normal homeostasis. In the gut, host intestinal serine proteases not only control digestion, but their unregulated activities contribute to the pathogenesis of | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $790,000 | Grant | Trans-NIH Recovery Act Research Support: Obesity is a major independent risk factor for type 2 diabetes mellitus (T2DM), obesity promotes chronic macrophage-mediated adipose tissue inflammation, resulting in increased release of free fatty acids from adipocytes and ectopic accumulation of trigly | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $701,878 | Grant | Trans-NIH Recovery Act Research Support: Recent evidence implicates cilia abnormalities as important in the etiology of Polycystic Kidney Disease. Our laboratory has defined an important role for polarity proteins, such as the apical transmembrane protein Crumbs3, in ciliogenesis. In the course | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $790,700 | Grant | Trans-NIH Recovery Act Research Support: MOTIVIATION - One of MRI?s inherent biophysical contrast parameters is proton self-diffusion, which can be measured by diffusion-weighted imaging (DWI). A variant, Diffusion Tensor Imaging (DTI), is an MRI method for noninvasive quantitative mapping of an | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| MAYO CLINIC | $696,204 | Grant | Trans-NIH Recovery Act Research Support: Lung disease is the third leading cause of mortality in the United States, has an economic impact of over $154 billion (USD) a year and in its chronic form impacts the lives of over 35 million Americans. Interstitial lung disease (ILD), which includes ove | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $851,135 | Grant | Trans-NIH Recovery Act Research Support: Prostate cancer is the most common male cancer, claiming almost 27,000 lives annually.1 One of the treatment options for localized prostate cancer is surgery?radical prostatectomy, which is performed in 70,000 patients every year in United States. The suc | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| OREGON STATE UNIVERSITY | $1,758,624 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Autoimmune and allergic diseases afflict millions of people worldwide. Novel immunosuppressive strategies to prevent and treat these diseases are urgently needed. Following several years of studying the potent immunosu | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $998,345 | Grant | Trans-NIH Recovery Act Research Support: Endocrine disrupting compounds (EDCs) are hormonally active, synthetic or natural chemicals that interfere with normal functioning of the endocrine system. Exposure to EDCs continues to be a significant and contentious public health issue. Because of the | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| SAINT LOUIS UNIVERSITY | $697,393 | Grant | Trans-NIH Recovery Act Research Support: HSV-1 virus infection of the cornea is a leading cause of infectious blindness. Corneal damage results from virus-induced inflammation of the cornea. These studies will address the role that corneal anti-inflammatory proteins play during herpetic c | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| GEMSTONE FOUNDATION | $487,500 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this research grant is to explore the relationship between visual skills and reading using rigorous scientific methods in school settings. Students in grades 3-5 will be assessed for visual skills (convergence, divergence, accommodative fa | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $820,000 | Grant | Trans-NIH Recovery Act Research Support: We previously described a naturally occurring mutation (Nuc1) in the Sprague-Dawley rat with a novel and unusual eye phenotype. Nuc1 is inherited as a single Mendelian locus with viable homozygotes and an intermediate phenotype in heterozygotes. The mutat | Health and Human Services, Department of / National Institutes of Health | 6/19/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $607,418 | Grant | Trans-NIH Recovery Act Research Support: The neural crest is a vertebrate innovation, sometimes referred to as the fourth germ layer; the neural crest gives rise to migrating cells that differentiate into cartilage, melanocytes, the peripheral nervous system, and the outflow tract of the heart. | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $382,474 | Grant | Trans-NIH Recovery Act Research Support: ParA systems play an important role in chromosome segregation and are responsible for the segregation of many bacterial plasmids. This proposal focuses on the ParA partitioning system of E. coli plasmid F, which consists of the SopA (ParA) ATPase, the So | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY | $0 | Grant | Trans-NIH Recovery Act Research Support: Understanding the regulatory mechanisms by which voltage-dependent calcium channels (VDCCs) and their Ca2+ signals are regulated is central to the development of a mechanistic picture of nervous system function. The dynamics (or shape) of intracellular Ca | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| CALIFORNIA INSTITUTE OF TECHNOLOGY | $1,042,544 | Grant | Trans-NIH Recovery Act Research Support: Mass spectrometry is one of the most important tools for proteomics. Especially important are new protocols recently implemented for the identification of low- concentration analytes in the presence of very large backgrounds. NEMS-based mass spectrometry | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF WASHINGTON | $624,000 | Grant | Trans-NIH Recovery Act Research Support: Human embryonic stem cells (ESCs) and induced pluripotent stem cells (IPSCs) can only be used effectively in recipients with the same (or nearly the same) histocompatibility type, to avoid rejection or toxic immunosuppression. To overcome this problem, v | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | $607,263 | Grant | Trans-NIH Recovery Act Research Support: A-synuclein (aSyn) is an intrinsically disordered protein that appears in aggregated form in the brains of patients with Parkinson's disease. The conversion of monomer to aggregate is complex. Aggregation rates of aSyn are very sensitive to changes in ami | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF UTAH, THE | $484,584 | Grant | Trans-NIH Recovery Act Research Support: Many species of bacteria swim using flagella, which consist of thin helical filaments turned by rotary motors in the cell membrane. Assembly of the bacterial flagellum depends on a specialized secretion apparatus at the base that exports the protein subun | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $709,800 | Grant | Trans-NIH Recovery Act Research Support: As a whole, mitochondrial diseases are among the most common hereditary diseases. They can arise from mutations of nuclear or mitochondrial (mtDNA) genes that encode for components of the oxidative phosphorylation (OXPHOS) machinery. It is clear that mito | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $1,187,066 | Grant | Trans-NIH Recovery Act Research Support: Neglect affects large numbers of children each year and its negative health, social, emotional and academic consequences to children are well documented. Despite this, there has been little theoretical or empirical work identifying its causes. Social info | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| MAGEE-WOMENS HEALTH CORPORATION | $783,687 | Grant | Trans-NIH Recovery Act Research Support: We are interested in understanding transcriptional regulation during early oogenesis, specifically the post-mitotic stages, and the transition from prenatal to postnatal ovary, when clusters of oocytes begin to form into primordial follicles. Early stages | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| NEW YORK UNIVERSITY (INC) | $826,238 | Grant | Trans-NIH Recovery Act Research Support: Role of ?-Tubulin Mutations in Lissencephaly. The purpose of this award is to characterize mutations in ?-tubulin that cause lissencephaly, with a view to developing approaches that might ameliorate the effect of these mutations. Lissencephaly is a catas | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| CENTER FOR CULTURAL AND TECHNICAL INTERCHANGE BETWEEN EAST AND WEST, INC. | $284,128 | Grant | Trans-NIH Recovery Act Research Support: The research develops a new method of multivariate analysis of the total fertility rate (TFR) and its components, applied to individual-level survey or census data. A discrete-time multivariate survival model, the complementary log-log (CLL) model, is use | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $763,360 | Grant | Trans-NIH Recovery Act Research Support: This project makes publicly available via ICPSR an existing longitudinal individual-level database, the Liaoning Multi-Generational Panel (LMGP), that comprises 1.3 million triennial observations of more than 230,000 residents of approximately 628 northea | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $1,451,263 | Grant | Trans-NIH Recovery Act Research Support: ARRA - Genetic by Context Influence on Trajectories of Adolescent Aggression 1R01HD057222-01A1 The overall purpose of our study is to gain a greater understanding of how the family and peer context of adolescents can buffer or exacerbate genetic influence | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $1,455,395 | Grant | Trans-NIH Recovery Act Research Support: Being born a girl or boy carries implications for physical and psychological health and illness. Considerable scientific and public interest is focused on the development and maintenance of these sex-related processes, but there are noticeable gaps that w | Health and Human Services, Department of / National Institutes of Health | 7/24/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $1,973,943 | Grant | Trans-NIH Recovery Act Research Support: HIV/AIDS continues to be a critical public health problem in the United States and men's heterosexual behavior plays a key role; 83% of women with HIV/AIDS are infected through sex with men. Among men who have sex with women (MSW), homeless men are a popu | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| WAKE FOREST UNIVERSITY | $946,933 | Grant | Trans-NIH Recovery Act Research Support: Human pluripotent stem cells (hPSCs) will be crucial for the development of regenerative therapies, especially when autologous specialized cells cannot be obtained in sufficient quantity. Despite great promise, pluripotent embryonic stem (ES) cells have s | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $739,625 | Grant | Trans-NIH Recovery Act Research Support: The development of the limb relies on reciprocal signaling between celln exists concerning the mechanisms of development to enable the majority of these defects to be detected or prevented pre-natally. An important goal is to develop animal models of cong | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $651,548 | Grant | Trans-NIH Recovery Act Research Support: The experiments proposed in this study were designed to investigate the role played by the phosphatidylinositol 3-kinase (PI3K) signaling pathways mediating leptin action on reproduction. These studies were proposed to better understand the role of the ad | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| OREGON STATE UNIVERSITY | $737,004 | Grant | Trans-NIH Recovery Act Research Support: Vitamin E was discovered in 1922 as a lipid soluble factor necessary for reproduction and named 1-tocopherol from the Greek words for birth and to carry. To date, a-tocopherol's role in reproduction has been impossible to approach experimentally because a | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF LOUISVILLE | $546,554 | Grant | Trans-NIH Recovery Act Research Support: The project attempts to provide MRI correlates to the described minicolumnopathy of autism. In this regard available postmortem MRI (both autistic and controls) will be examined for gyral window measurements and correlated to computerized image analysis | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $808,068 | Grant | Trans-NIH Recovery Act Research Support: Arterial baroreceptors (BR) are essential for reliable neural control of heart rate and blood pressure. The data quantifying the properties of these pressoreceptors and the reflexogenic consequences of BR function and dysfunction are extensive. Experiment | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| MAYO CLINIC | $906,630 | Grant | Trans-NIH Recovery Act Research Support: The broad objective of this new application is to advance our understanding of the pathophysiological mechanisms of human Cardiorenal Syndrome (CRS) with a specific emphasis upon the biological interaction between diuretic therapy, the renin-angiotensin-a | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $1,265,929 | Grant | Trans-NIH Recovery Act Research Support: Our tissue engineering approach to heart muscle regeneration combines heart cells with a biodegradable polymer template (scaffold) in a laboratory culture device (bioreactor) to create a contractile heart muscle graft. Such tissue engineered cardiac graft | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| MEHARRY MEDICAL COLLEGE | $864,960 | Grant | Trans-NIH Recovery Act Research Support: This project tests a hypothesis that activation of the endoplasmic reticulum stress-related signaling pathways is a mechanism by which apolipoproteins (fats that combine with proteins for transport in the blood) in ApoE-deficient lipoprotein mice regulate | Health and Human Services, Department of / National Institutes of Health | 6/21/2009 |
| WASHINGTON UNIVERSITY, THE | $778,783 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this research initiative remains to delineate the cytoprotective role of proinflammatory cytokines in myocardial ischemia reperfusion (I/R) injury. We previously made the observation that the cytoprotective effects of tumor necrosis | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF ARIZONA | $908,033 | Grant | Trans-NIH Recovery Act Research Support: Ischemic reperfusion (I/R) is known to trigger an increase of reactive oxygen species in the myocardium. Although high levels of oxidants can cause damages, low doses of oxidant elicit a protective effect, such as during preconditioning induced by cycles | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $933,519 | Grant | Trans-NIH Recovery Act Research Support: Endothelial response to fluid shear stress has been strongly implicated as a key factor in the focal development of atherosclerotic lesions in human arteries. The hypothesis of this grant is that the glycocalyx plays a pivotal role in the transduction of | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $809,181 | Grant | Trans-NIH Recovery Act Research Support: In response to changing afferent input, neural pathways may undergo both short term (minutes) and long term (days, weeks) adjustments within the pathway in order to maintain physiological output within an appropriate range. The underlying cellular mechani | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF OKLAHOMA | $1,680,075 | Grant | Trans-NIH Recovery Act Research Support: Evidence-based guidelines for asthma management have been available to practicing physicians since 1991.1 Randomized controlled clinical trials have demonstrated that implementation of asthma guideline recommendations can significantly improve patient- le | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF IOWA, THE | $745,884 | Grant | Trans-NIH Recovery Act Research Support: Severe sepsis is a systemic response to infection that culminates in acute organ failure. Preclinical models of sepsis demonstrate that a disturbed microvasculature characterized by hyporesponsive vessels and heterogeneous flow contributes to organ failur | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $929,250 | Grant | Trans-NIH Recovery Act Research Support: Cardiac valve thickening is a major cardiovascular manifestation of connective tissue disorders (e.g., Marfan syndrome (MFS) and Ehlers-Danlos syndrome (EDS)), and non-syndromic valvular diseases. In humans POSTN protein is reduced in pediatric patients w | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $852,638 | Grant | Trans-NIH Recovery Act Research Support: Macrophages are the most prominent cell type in atherosclerotic lesions, and are associated with three hallmarks of the disease:lipid deposition, inflammation, and macrophage-derived foam cell disordered apoptosis. The ability to regulate SMS activity cou | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $38,217 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The overall aim of this work is to understand how the growth of the adult pancreas is regulated to provide an adequate supply of digestive enzymes. We hypothesize that growth can occur by two mechanisms. The first occu | Health and Human Services, Department of / National Institutes of Health | 6/14/2009 |
| WASHINGTON UNIVERSITY, THE | $60,800 | Grant | Trans-NIH Recovery Act Research Support: Epithelial-mesenchymal interactions are required for normal intestinal morphogenesis and have a critical role in epithelial carcinogenesis. The focus of the parent grant is to elucidate the role of mesenchymally derived subepithelial myofibroblasts in med | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| UNIVERSITY OF CHICAGO, THE | $56,338 | Grant | Trans-NIH Recovery Act Research Support: Defective intestinal transport is a central component of many intestinal diseases. Such transport, in the form of nutrient, ion, and water absorption, is accomplished by specific transcellular transporters as well as passive paracellular movement across t | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF SOUTH ALABAMA | $846,710 | Grant | Trans-NIH Recovery Act Research Support: THIS PROJECT WILL TEXT THE FOLLOWING WORKING HYPOTHESIS. THE ACTIVITY OF THE HIGH AFFINITY PDE7 LOWERS CAMP LEVELS AND INCREASES BARRIER PERMEABILITY OF PULMONARY ARTERIAL ENDOTHELIAL CELLS. THE FOLLOWING SPECIFIC AIMS OUTLINE A PLAN TO TEST THIS HYPOTHES | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| WASHINGTON UNIVERSITY, THE | $1,415,786 | Grant | Trans-NIH Recovery Act Research Support: Nanomedicine approaches to atherosclerotic disease could have significant impact on the practice and outcomes of cardiovascular medicine. With recent concerns about the use of gadolinium and its relationship to Nephrogenic Systemic Fibrosis (NSF), alterna | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $1,612,227 | Grant | Trans-NIH Recovery Act Research Support: Worldwide, survival in HIV-infected patients has remarkably improved with the use of highly active anti- retroviral therapy (HAART); however, survival in HIV-infected patients remains decreased compared to the general population in part due to excess deat | Health and Human Services, Department of / National Institutes of Health | 8/12/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $882,726 | Grant | Trans-NIH Recovery Act Research Support: Heart transplantation is often the only available therapeutic option in end-stage heart disease. To monitor graft survival, recipients endure frequent invasive endomyocardial biopsies which carry a significant risk of complication and are prone to samplin | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF KENTUCKY | $799,237 | Grant | Trans-NIH Recovery Act Research Support: Cardiovascular disease is the leading cause of death in developed countries. Individuals with obesity, metabolic syndrome, and/or diabetes are at markedly increased risk of atherosclerotic cardiovascular disease although the underlying mechanisms are not | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $1,027,698 | Grant | Trans-NIH Recovery Act Research Support: Literature and Data Driven Hypothesis Generation for High Throughput Experiments Microarray gene expression analyses are used widely in biomedical research today. Thousands of genes can be assayed in a single experiment, and differences in their expressio | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $847,500 | Grant | Trans-NIH Recovery Act Research Support: This new, revised R01 application is based on the success in achieving the goals of a previous R21 award, i.e. the creation of a 'striatal-specific' transgenic mouse model of Huntington's disease. In brief, this mouse model, demonstrates medium spiny nucl | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $1,394,991 | Grant | Trans-NIH Recovery Act Research Support: Despite significant progress in stroke prevention and its acute treatment, stroke remains the third leading cause of death and the leading cause of adult morbidity worldwide. Fundamental advances in stroke will require collecting and pooling advanced phen | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $718,108 | Grant | Trans-NIH Recovery Act Research Support: The sphingolipid storage diseases are a group of ~40 genetically distinct disorders that result from inherited deficiencies of lysosomal hydrolytic activities or lipid transport. Among this group is Niemann-Pick type C disease, an autosomal recessive diso | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $1,223,856 | Grant | Trans-NIH Recovery Act Research Support: Purpose: to examine deficits in planning movements, specifically task switching, due to Parkinson's disease (PD). Task switching is the ability to make a change in the plan (switching from one response option to another, e.g. pressing one button vs. anot | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $887,778 | Grant | Trans-NIH Recovery Act Research Support: Glutamate-mediated excitotoxicity is believed to be involved in the pathogenesis of many neurological disorders, such as amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD). Excitotoxicity is defined as excessive exposure to the neurotransmit | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| UNIVERSITY OF ALASKA FAIRBANKS | $660,988 | Grant | Trans-NIH Recovery Act Research Support: Nicotinic receptors have been implicated in a broad range of neurological disorders including Alzheimer?s disease (AD), Schizophrenia, Autism, Frontal Lobe Epilepsy,Parkinson?s disease, Tourette Syndrome and Attention Deficit Disorder. Given the increasin | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| UNIVERSITY OF MARYLAND | $750,000 | Grant | Trans-NIH Recovery Act Research Support: Insults to the brain and spinal cord result not only in debilitating motor, sensory and cognitive deficits, but also in chronic, excruciating and relentless pain that is largely resistant to treatment. In most patients, pain starts weeks or months after t | Health and Human Services, Department of / National Institutes of Health | 9/20/2009 |
| OHIO STATE UNIVERSITY, THE | $750,260 | Grant | Trans-NIH Recovery Act Research Support: The goal of this proposal is to elucidate the role of the p42/44 mitogen-activated protein kinase (MAPK) pathway as a regulator excitotoxic cell death and aberrant structural remodeling in the hippocampus. Traumatic brain injury-induced cell death and pat | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $147,500 | Grant | Trans-NIH Recovery Act Research Support: This project investigates the role of beta-arrestin 1 and 2 as negative regulators of inflammatory response in collagen-induced arthritis. Understanding beta-arrestin 1 and 2 expression in correlation to the disease severity, its cellular specificity in t | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $164,000 | Grant | Trans-NIH Recovery Act Research Support: Culture and Identification of Rickettsia-like Organisms in Maryland: the specific aims of this project are to 1) use shell-vial culture techniques to culture/isolate known and unknown Rickettsia-like organisms from man-biting ticks of Maryland and 2) to i | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $148,500 | Grant | Trans-NIH Recovery Act Research Support: This project is being supported with funds from the American Recovery and Reinvestment Act, which may involve a reduction in the research aims and scope. If necessary, a revised abstract will be posted soon and this notice removed. DESCRIPTION (provided | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| VIRGINIA COMMONWEALTH UNIVERSITY | $149,479 | Grant | Trans-NIH Recovery Act Research Support: Human cytomegalovirus is the major infectious cause of birth defects in the United States. We recently found that two current candidate vaccines fail to elicit high levels of antibodies that block viral entry into epithelial cells. Based on these results, | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| PURDUE UNIVERSITY | $152,500 | Grant | Trans-NIH Recovery Act Research Support: The broad, long range objective is to understand molecular mechanisms that regulate initiation of skeletal muscle (skm) atrophy. The objective of this application is to explore the role of Merg1a in initiation of skm atrophy. The central hypothesis is tha | Health and Human Services, Department of / National Institutes of Health | 6/10/2009 |
| UNIVERSITY OF MISSOURI SYSTEM | $142,716 | Grant | Trans-NIH Recovery Act Research Support: Although osteoporosis affects more than 2 million men in the United States today and nearly 12 million more have osteopenia, low bone mass often goes undiagnosed and inadequately treated in males (Wright 2006). The overall goal of the proposed study is t | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $175,941 | Grant | Trans-NIH Recovery Act Research Support: In surgical education, an apprenticeship model has long been traditional. However, this model is increasingly being challenged due to the rapid development of increasingly complex and minimally- invasive procedures that are associated with steep learning | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| BAYLOR COLLEGE OF MEDICINE | $138,970 | Grant | Trans-NIH Recovery Act Research Support: Purpose: to validate and to measure N-nitroso compound intake in the total US population and by ethnic group and personal factors ABSTRACT: This application is a formative step towards assessing dietary intake of N-nitroso compounds in populations to | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $176,000 | Grant | Trans-NIH Recovery Act Research Support: This study will explore the relationship between reported tobacco use and presence/amount of cotinine (an objective biomarker of smoking) in existing specimens linked to a large, widely available dataset often used for epidemiologic research, including fo | Health and Human Services, Department of / National Institutes of Health | 8/12/2009 |
| UNIVERSITY OF WASHINGTON | $156,000 | Grant | Trans-NIH Recovery Act Research Support: Head and neck cancers (HNSCC) are the fifth most common malignancy worldwide. Human papillomavirus (HPV) infection has recently been identified as an etiologic agent for development of a subgroup of HNSCC (i.e., oral-pharyngeal cancers) with up to a third | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $151,000 | Grant | Trans-NIH Recovery Act Research Support: Curcumin, a naturally occurring dietary polyphenol, has shown significant potential as a chemopreventive in cell culture models of breast cancer. However, curcumin suffers from poor oral bioavailability in vivo, resulting in sub-optimal systemic exposure | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $81,250 | Grant | Trans-NIH Recovery Act Research Support: Co-occurrent substance use and violence compromises the health, safety, well-being, and life chances for adolescents. Although research has identified important risk and protective factors for substance use and violence independently, less is known about | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| CLEMSON UNIVERSITY | $222,656 | Grant | Trans-NIH Recovery Act Research Support: Temporomandibular joint disorders (TMDs) are an important national health problem affecting more than 10 million people in the United States. Although the exact cause of TMDs is unclear, the temporomandibular joint (TMJ) disc pathophysiology (i.e., disc d | Health and Human Services, Department of / National Institutes of Health | 4/29/2009 |
| UNIVERSITY OF TOLEDO, THE | $224,699 | Grant | Trans-NIH Recovery Act Research Support: Overall Purpose: This proposal focuses on development of a new approach for regenerating natural bone tissues, with emphasis on developing injectable hybrid microparticles providing osteoconductivity, osteoinductivity and structural integrity into micropa | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | $163,578 | Grant | Trans-NIH Recovery Act Research Support: Radiological exposure from a terror event has been identified by the CDC and the Office of Homeland Security as a potential threat worthy of significant national preparedness. Little research has been done, however, to develop risk communication strategie | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $163,303 | Grant | Trans-NIH Recovery Act Research Support: Despite aggressive public education campaigns, maternal tobacco smoking remains an important public health problem. Our murine model of gestational maternal smoking demonstrates significant alveolarization abnormalities, including fewer alveoli and decrea | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY M | $153,000 | Grant | Trans-NIH Recovery Act Research Support: The award will focus on a common but poorly understood disease of the human female reproductive tract, uterine leiomyomas. Our preliminary findings deomonstrate that leiomyomas alter their molecular expression patterns to decrease retinoic acid concentra | Health and Human Services, Department of / National Institutes of Health | 7/27/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $169,500 | Grant | Trans-NIH Recovery Act Research Support: Non-motile, primary cilia are found on the surface of a strikingly diverse range of cell types and play critical roles in development and disease, including polycystic kidney disease, hydrocephalus, syndromic obesity, and retinal degeneration. A prominent | Health and Human Services, Department of / National Institutes of Health | 5/11/2009 |
| AUBURN UNIVERSITY | $73,166 | Grant | Trans-NIH Recovery Act Research Support: This project will investigate the influence of mastery motivation climate physical eduction programming on physical activity in rural african American children (ages 5-8) who are risk for poor health. The long term goal is to provide school age children | Health and Human Services, Department of / National Institutes of Health | 6/22/2009 |
| MICHIGAN STATE UNIVERSITY | $141,002 | Grant | Trans-NIH Recovery Act Research Support: This pilot study will examine the adverse influence of prenatal and postnatal exposure to intimate partner violence (IPV: male violence toward their female partners) on one year old infants' emotional and physiological [i.e., hypothalamic-pituitary-adrena | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF NOTRE DAME DU LAC | $150,000 | Grant | Trans-NIH Recovery Act Research Support: Our project will consider an alternative and previously-overlooked explanation: that children born throughout the year are not initially similar but are conceived by women with different socioeconomic characteristics. To consider this alternative explanat | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $78,810 | Grant | Trans-NIH Recovery Act Research Support: Aggression and victimization are both risk factors for social-psychological adjustment problems and future psychopathology. The study of the developmental course of aggression and victimization among children is crucial for identifying children most at ri | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| NORTHWESTERN UNIVERSITY | $164,476 | Grant | Trans-NIH Recovery Act Research Support: Research has consistently shown that children's eating and weight status are strongly influenced by parental feeding styles and practices. Because it is infeasible to randomize naturalistic behaviors, data that relate feeding practices to child eating typ | Health and Human Services, Department of / National Institutes of Health | 4/27/2009 |
| NORTH DAKOTA STATE UNIVERSITY | $143,500 | Grant | Trans-NIH Recovery Act Research Support: In the United States, 20.8 million people (7% of the population) suffer from diabetes. About 75% of all newly diagnosed cases of type I diabetes occurs in individuals younger than 18 years of age. Type 1 diabetes is a chronic autoimmune disease affecting | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| NORTH DAKOTA STATE UNIVERSITY | $143,500 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Intrauterine growth restriction is a significant cause of fetal and neonatal mortality and morbidity and is major health-related problems in the U.S. Growth-restricted infants that survive the neonatal period have an i | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF KENTUCKY | $148,416 | Grant | Trans-NIH Recovery Act Research Support: Airway inflammation, airway remodeling, colonization with microorganisms, and parenchymal destruction are hallmarks of chronic obstructive pulmonary disease (COPD). In addition to cigarette smoking, infectious pathogens likely contribute to the decline in | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE | $149,000 | Grant | Trans-NIH Recovery Act Research Support: Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease of unknown etiology, characterized by scaring in the lung and impaired pulmonary function. The pathogenetic mechanisms leading to IPF are poorly understood, and there are curre | Health and Human Services, Department of / National Institutes of Health | 5/11/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $154,878 | Grant | Trans-NIH Recovery Act Research Support: Voltage-sensitive potassium (Kv) channels are proteins that exist in the membranes of all electrically excitable cell types. Kv1.4 (the mammalian homologue of Shaker) and all Kv4 (Shal-type) subunits generate potassium-selective current phenotypes design | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON | $153,000 | Grant | Trans-NIH Recovery Act Research Support: Glioblastoma (GB) is the most common type of brain tumor and is usually rapidly fatal. Clinical trials indicate that treatment with temozolomide (TMZ) coupled with chemotherapy is beneficial to patients. Unfortunately, only a small number of patients resp | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $148,500 | Grant | Trans-NIH Recovery Act Research Support: Every year, thousands of humans suffer traumatic brain injury (TBI) and most of the survivors manifest moderate to severe neurological dysfunction. Currently no known therapies that can prevent secondary neuronal death and/or promote neurological recovery | Health and Human Services, Department of / National Institutes of Health | 9/20/2009 |
| BOWLING GREEN STATE UNIVERSITY (INC) | $203,820 | Grant | Trans-NIH Recovery Act Research Support: The long-range goal of this project is to generate a fluorescence-based microarray diagnostic platform and a rugged device capable of reading DNA and/or protein microarrays for performing the routine array-based comprehensive DNA, protein, pathogen, etc. | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| UNIVERSITY OF ALASKA ANCHORAGE | $197,600 | Grant | Trans-NIH Recovery Act Research Support: The transcription factor MRF4 is an important regulator of numerous other genes involved in the development, growth, and regeneration of skeletal muscle cells. Elucidating the mechanisms that regulate MRF4 gene transcription should improve our understand | Health and Human Services, Department of / National Institutes of Health | 8/07/2009 |
| WHEATON COLLEGE | $192,094 | Grant | Trans-NIH Recovery Act Research Support: Cilia are complex and essential cellular machines that propel fluid over cells and sense stimuli in the environment. Recent discoveries about the central role that ciliary defects play in many human diseases and birth defects have energized the field of c | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| VALDOSTA STATE UNIVERSITY | $194,538 | Grant | Trans-NIH Recovery Act Research Support: The long-term objective of this proposal is to understand the genetic and hormonal mechanisms controlling gonad development in vertebrates. Primary sex determination in most vertebrates results in the development of a single gonad, ovary or testis, from | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| WHITMAN COLLEGE, INC | $222,814 | Grant | Trans-NIH Recovery Act Research Support: This National Institutes of Health AREA award will permit novel research at Whitman College in the area of developmental neurobiology. The proposed studies characterize the relationship between glial cells and synapse development. There is a diverse array | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| CENTRE COLLEGE OF KENTUCKY | $206,100 | Grant | Trans-NIH Recovery Act Research Support: This research project, G?Phenotype analysis of tyrosine hydroxylase neurons in rat and human cortices,G? explores the neurochemical phenotype of a subset of cortical interneurons in rats and humans. Understanding the phenotypic diversity of cortical inter | Health and Human Services, Department of / National Institutes of Health | 5/01/2009 |
| UNIVERSITY OF UTAH, THE | $459,713 | Grant | Trans-NIH Recovery Act Research Support: This research addresses an important public need, the protection of an estimated 10 million workers in the U.S. who rely heavily on their voice as a primary tool of trade. Evidence has been growing that occupational voice users, such as teachers, telephon | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| FLORIDA STATE UNIVERSITY, THE | $245,174 | Grant | Trans-NIH Recovery Act Research Support: The rate of protein-protein association plays critical roles in many fundamental biological processes ranging from enzyme catalysis/inhibition to regulation of immune response by cytokines. Our long-term objectives are to reliably predict association rate | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) | $134,391 | Grant | Trans-NIH Recovery Act Research Support: This NOT-OD-09-05 Administrative Supplement Grant supplement request seeks to obtain additional experimental evidence to support a principal finding to emerge from the parent grant, namely, that conditions that enhance errors during protein synthesis (mis | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| UNIVERSITY OF CHICAGO, THE | $42,426 | Grant | Trans-NIH Recovery Act Research Support: The long-term goals of our laboratory are to understand though genetic analysis the evolutionary forces producing new species and species differences in behavioral and morphological traits, to identify the genes involved in such differences and, ultimatel | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $174,559 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this grant is to study the function of the annealing helicase HARP in Drosophila melanogaster. In research funded by the parental grant (NIH R01 GM058272), we discovered that human HARP protein has a novel reverse (annealing) helicase activ | Health and Human Services, Department of / National Institutes of Health | 7/30/2009 |
| MISSOURI SYSTEM, UNIVERSITY OF | $187,490 | Grant | Trans-NIH Recovery Act Research Support: The primary objective of this project is to examine factors that are associated with the effectiveness of intervention programs designed to reduce high-risk drinking among heavy drinking college students. Previous research has found similar effect sizes f | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL | $396,000 | Grant | Trans-NIH Recovery Act Research Support: Asymptomatic gonococcal cervicitis is the primary factor contributing to the prevalence of gonorrhea in the general population as well as in the chronic disease sequelae observed, disproportionately, among women. That gonococcal disease in women is, in pa | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF TEXAS HEALTHCARE AT TYLER | $377,500 | Grant | Trans-NIH Recovery Act Research Support: Tuberculosis remains a major health problem throughout the world, and development of vaccine is the most effective measure to control tuberculosis epidemic. Understanding the interactions between Mycobacterium tuberculosis (pathogen) and humans (host) is | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $37,166 | Grant | Trans-NIH Recovery Act Research Support: The significance of a sound is encoded not only in the firing patterns distributed throughout the auditory system, but also by the internal and external state of the animal. In other words, the processing involves not only the auditory system but also neu | Health and Human Services, Department of / National Institutes of Health | 5/28/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $203,850 | Grant | Trans-NIH Recovery Act Research Support: We have begun with identifying cell surface markers expressed by otic progenitor cells. To date, we have narrowed down the list of markers to 28, which we are systematically testing for robust expression on Pax2/Pax8/Dlx5-positive otic progenitors genera | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| EAST CAROLINA UNIVERSITY | $175,595 | Grant | Trans-NIH Recovery Act Research Support: Since March, funds continue to maintain one graduate research assistant and one postdoctoral scholar. The purpose of the supplement was to increase the number of animals phenotyped for inner ear function and the number of specimens undergoing morphologica | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF OKLAHOMA | $99,300 | Grant | Trans-NIH Recovery Act Research Support: This project is for additional needed equipment to augment pursuit of our research activities along four specific aims of the parent grant. The long-term goal of this project is to determine how the structure and mechanical properties of human ear affect | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $144,039 | Grant | Trans-NIH Recovery Act Research Support: This request for an ARRA Administrative Supplement is designed to accelerate the science funded by the parent grant entitled Neural Plasticity in the Adult Gustatory System (# ROl DC006938). The primary aim of the supplement is to accelerate our new work | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $158,534 | Grant | Trans-NIH Recovery Act Research Support: The goal of this proposal is to determine the role of lipids in mechanotransduction by hair cells. We propose three specific aims. In Aim 1, we will determine which lipids are present in hair bundles using mass spectrometry and histochemical localization. | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $125,130 | Grant | Trans-NIH Recovery Act Research Support: We have recently demonstrated that new inner hair cells (IHCs) are generated in the mammalian organ of Corti following gene therapy. Specifically, the experiments involve in vivo inoculation of an adenovirus vector with the Atohl gene insert (M.Atohl) int | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| NORTHEAST OHIO MEDICAL UNIVERSITY | $334,620 | Grant | Trans-NIH Recovery Act Research Support: This award provides additional funding for 5R01DC008120-05. This additional funding is provided under the American Recovery and Reinvestment Act of 2009 (ARRA). This award provides funds to develop tools to examine the coding of sound information in the | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $235,483 | Grant | Trans-NIH Recovery Act Research Support: There is an overwhelming body of evidence that links sarcopenia, the age-related changes in muscle size, strength, and function, to anatomical and physiological changes within motoneurons, nerve-muscle connections, and the muscles themselves. In addition | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| THE VANDERBILT UNIVERSITY | $189,205 | Grant | Trans-NIH Recovery Act Research Support: The purpose of the parent project is to compare speech intervention methods for improving speech accuracy and speech intelligibility in children with Down Syndrome. In keeping with the NIDCD and broader NIH guidelines, the proposed supplement is designed | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF IOWA, THE | $249,490 | Grant | Trans-NIH Recovery Act Research Support: The hair cell, located in the inner ear, is an essential component of the hearing process. The actin cytoskeleton plays a major role in hair cell function, through both the actin filament bundle in the stereocilium and the actin web in the cuticular plate | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $333,770 | Grant | Trans-NIH Recovery Act Research Support: In this supplement, we extend the reach of our parent grant in a project called TOTLOT Outreach. The goals are to increase the diversity of our participant base, and to expand our professional and technical staff so that we can explore more deeply an exc | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $279,542 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of the proposed project is to identify the neurotransmitters and modulators involved in mediating vestibulo-autonomic synaptic interactions. The four aims address the chemoanatomy and synaptology of these vestibular projections in adult | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | $147,796 | Grant | Trans-NIH Recovery Act Research Support: Songbirds are the most easily studied of the few animal groups that learn to produce vocal signals for social communication as humans do. Among songbirds, our knowledge of the zebra finch is most advanced and provides the best developed model system for u | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF OKLAHOMA | $39,565 | Grant | Trans-NIH Recovery Act Research Support: Cortical processing of sensory information plays a critical role in sensory discrimination, object recognition and memory. Cortical sensory processing has been shown to be highly dynamic, with past experience, current context and expectations shaping how | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| WASHINGTON UNIVERSITY, THE | $192,861 | Grant | Trans-NIH Recovery Act Research Support: This CLIN supplement proposes four goals that extend studies outlined in the parent grant 'Effects of Asymmetric Hearing in Acoustic Listeners and Cochlear Implant Users'. The premise of the parent grant is that listening with just one ear seriously deg | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $78,491 | Grant | Trans-NIH Recovery Act Research Support: This grant will upgrade the research equipment used to study the olfactory system's effects on human physiology and behavior, and also help stimulate the economy and create jobs by allowing purchases of the new equipment. | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| PURDUE UNIVERSITY | $225,405 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to assess the efficacy of a new treatment for hypophonia (decreased vocal loudness) associated with Parkinson's disease (PD). Current speech therapy strategies for hypophonia focus on increasing sound pressure level. It is clea | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $264,156 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): These studies have direct relevance for improving our understanding of the developmental defects associated with Chd7 deficiency. Precise regulation of gene expression is critical for normal development of most tissues | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $441,564 | Grant | Trans-NIH Recovery Act Research Support: Little is known of the inflammatory mechanisms of chronic otitis media that lead to inner ear pathology. Therefore, the long-term goal of this research program is to identify and prevent the inflammatory processes by which chronic middle ear disease cause | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| WILLIAM MARSH RICE UNIVERSITY | $296,552 | Grant | Trans-NIH Recovery Act Research Support: Cochlear outer hair cells enhance the sensitivity of mammalian hearing through active mechanical feedback powered by the membrane protein prestin. The long-term goal of our research efforts is to understand the mechanism by which prestin interacts with th | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| SOUTHERN ILLINOIS UNIVERSITY | $181,492 | Grant | Trans-NIH Recovery Act Research Support: The primary purpose of the supplementary award was to accelerate our research applying MRI imaging technology to investigate the pathological correlates of tinnitus in an animal model. The second purpose of the supplement was to significantly upgrade soun | Health and Human Services, Department of / National Institutes of Health | 7/31/2009 |
| CORNELL UNIVERSITY, INC | $100,000 | Grant | Trans-NIH Recovery Act Research Support: This proposal presents a multidisciplinary approach to understanding a fundamental property of sensory processing: the modulation of sensory perception by acetylcholine. The proposal addresses this question in the olfactory bulb of rats, using a combinati | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $8,150 | Grant | Trans-NIH Recovery Act Research Support: We investigate the physiologic regulatory mechanisms for amelogenin expression during enamel formation. In situ hybridization of in vivo developing mouse incisors identified a periodicity for amelogenin transcript accumulation wherein one sagittal row of | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| NEW YORK UNIVERSITY (INC) | $206,036 | Grant | Trans-NIH Recovery Act Research Support: Fibroblast growth factor receptors (FGFRs) play essential roles in human development and metabolism. The overall aim of this application is to understand how the activity of FGFRs is regulated and to unveil the mechanisms by which naturally occurring pat | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $14,935 | Grant | Trans-NIH Recovery Act Research Support: This supplement will be used to expand Aim 2 of the parent grant by determining the mechanism underlying reorganization of ductal progenitors into ductal structures and elucidating the role of myosin II and tensile forces in the stabilization of E-cadheri | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF ROCHESTER | $205,288 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this administrative supplement is to support a new collaboration (subcontract with Dr. Michael Lovett at Washington University) to use the next-generation sequencing technologies to sequence the entire genomic region containing the Twirler | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $201,890 | Grant | Trans-NIH Recovery Act Research Support: Understanding how apoptosis is regulated in salivary gland cells is critical for the development of therapeutics to protect salivary glands from irradiation induced damage and for the treatment of Sjogren's syndrome, salivary tumors and other diseases to | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK INC | $263,339 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this administrative supplement is to recruit a highly skilled postdoctoral research scientist who will work on the creation of anatomically shaped human bone grafts for craniofacial repair. The researcher will focus on: (a) advancing the ex | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $258,343 | Grant | Trans-NIH Recovery Act Research Support: This longitudinal study addresses the relationship between birth weight and early childhood caries (ECC) in a cohort of pre-term very low birth weight (VLBW) and full-term normal birth weight (NBW) infants. VLBW and ECC disproportionately affects poor and | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF ILLINOIS | $13,188 | Grant | Trans-NIH Recovery Act Research Support: For this project supported by the Recovery Act we employed two student workers and allowed them to work on hands-on lab projects related to our parent grant on amelogenin function in enamel evolution. Tooth enamel consists of tightly packed carbonated | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $123,112 | Grant | Trans-NIH Recovery Act Research Support: The overall long-term objectives of this research are to elucidate mechanisms by which cell surface metalloproteinases and their secreted counterparts are regulated and interact, activate and degrade peptides and proteins at the cell surface and extracell | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $91,324 | Grant | Trans-NIH Recovery Act Research Support: Psychophysiology of Irritable Bowel Syndrome ARRA The scientific aims are identical to those of the parent grant, namely to (1) identify single nucleotide polymorphisms (SNPs) associated with irritable bowel syndrome (IBS) diagnosis or subtypes of IBS; ( | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| COLORADO STATE UNIVERSITY | $30,576 | Grant | Trans-NIH Recovery Act Research Support: The proposed experiments are designed to thoroughly test important aspects of the hypotheses presented in the parent grant. Thus the resulting data should greatly advance understanding of how mRNA stabilization is achieved and how this process mediates th | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| THE VANDERBILT UNIVERSITY | $100,000 | Grant | Trans-NIH Recovery Act Research Support: In examining the effect of vitamin C or ascorbic acid on endothelial function as part of DK050435, we made the surprising discovery that ascorbate traverses the endothelial barrier not through the cells, as expected, but around the cells in a para cellula | Health and Human Services, Department of / National Institutes of Health | 8/24/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $100,000 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of our studies is to understand the regulation, function, and disease association of the keratin intermediate filament (IF) cytoskeletal proteins in digestive organs. Keratins 8 and 18 (K8/K18) are the IFs of hepatocytes and their major f | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $100,000 | Grant | Trans-NIH Recovery Act Research Support: In disease states, unfolded proteins accumulate in the endoplasmic reticulum because the folding capacity is exceeded, initiating a cellular stress response (the unfolded protein response or UPR). Our long-term interest is to understand the molecular mech | Health and Human Services, Department of / National Institutes of Health | 8/21/2009 |
| UNIVERSITY OF ILLINOIS | $97,461 | Grant | Trans-NIH Recovery Act Research Support: Monocarboxylate transporter 1 (MCT1) is involved in the luminal absorption of butyrate in human intestinal epithelial cells (hIECs). Since, butyrate absorption is crucial in determining colonocyte health and epithelial integrity, it is essential to under | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF MARYLAND | $115,388 | Grant | Trans-NIH Recovery Act Research Support: The proposed study builds upon findings from the parent grant and expands the scope of its specific aims, research design, and methods. Specifically, the focus of the parent grant is to apply high throughput genomic approaches in human samples to localize | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | $15,048 | Grant | Trans-NIH Recovery Act Research Support: Obesity is a serious health problem throughout the world, and contributes to an increased prevalence of Type II diabetes, cardiovascular disease, and cancer. Despite a need for therapeutic options to treat obesity, little is known about the mechanisms tha | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| VIRGINIA COMMONWEALTH UNIVERSITY | $100,165 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this grant is to explore the mechanisms of end-stage renal disease (ESRD) associated with hypertension and hyperhomocysteinemia (hHcys). We seek to define the molecular mechanisms that contribute to the early events mediating glomerula | Health and Human Services, Department of / National Institutes of Health | 8/29/2009 |
| BOSTON MEDICAL CENTER CORPORATION | $60,184 | Grant | Trans-NIH Recovery Act Research Support: This supplement is designed to accelerate the progress in Aim 3 of the parent grant by teaching summer students to prepare mitochondria and sub-mitochondria particles and test the effects of reactive species, as outlined above, on respiration and proton f | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| NEW YORK UNIVERSITY (INC) | $91,675 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The long-term goal of this project is to gain a better understanding of the molecular pathogenesis of urinary stone disease or urolithiasis. A centrally important function in maintaining urinary system homeostasis is | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $99,900 | Grant | Trans-NIH Recovery Act Research Support: Claudins are tight junction proteins that determine paracellular permeability and probably form the lining of the paracellular pore. In the renal tubule, they play important roles in electrolyte and acid-base handling. The long-term goal of this proposal | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF MARYLAND | $100,000 | Grant | Trans-NIH Recovery Act Research Support: The overarching goals of this supplemental application are: 1) accelerate the tempo of studies outlined in the parent application to elucidate the molecular mechanisms responsible for polarized targeting of a kidney potassium channel that helps control po | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION | $85,837 | Grant | Trans-NIH Recovery Act Research Support: The original aims of DK64668 were to interrogate the basic mechanistic underpinnings of microvascular dysfunction that develop in the OZR model of the metabolis syndrome and to determine how these alterations contribute to a impaired state of skeletal mus | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $100,000 | Grant | Trans-NIH Recovery Act Research Support: The nature of the signals that regulate intestinal stem cells and mediate the establishment of this hierarchical organization of the epithelium during normal gastrointestinal development has not yet been defined. We have recently found that expression of | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF FLORIDA | $99,999 | Grant | Trans-NIH Recovery Act Research Support: This is a one-year supplement request for DK065096; Hepatic stem cells: Fusion or Plasticity. The long term goal of the parent grant is to understand the mechanisms by which hepatic oval stem cells are activated into proliferation and migration as well as | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $100,000 | Grant | Trans-NIH Recovery Act Research Support: The awarded supplement relates to specific aims 1 and 2 of the parent grant (DK065872) on the effects of dietary obesity on midbrain dopamine systems. The proposed experiments are following up on progress achieved so far. We are now adding calorie-restric | Health and Human Services, Department of / National Institutes of Health | 7/31/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $100,000 | Grant | Trans-NIH Recovery Act Research Support: Vitamin E (Tocopherol) is the major fat-soluble antioxidant in humans, and serves a critical function in protection against a plethora of oxidative-stress-related pathologies. However, surprisingly little is known about the molecular mechanisms that regul | Health and Human Services, Department of / National Institutes of Health | 8/24/2009 |
| EMORY UNIVERSITY | $68,541 | Grant | Trans-NIH Recovery Act Research Support: Title: Administrative supplement for pyrophosphate in vascular calcification of renal failure. Pyrophosphate (PPi) is a potent endogenous inhibitor of vascular calcification. The purpose of the project is to apply new techniques , specifically geneti | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| UNIVERSITY OF UTAH, THE | $90,287 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Ferroportin (Fpn, IREG1, MTP1) is the only identified transmembrane iron exporter in vertebrates. Our preliminary data indicate that hepcidin inhibits cellular iron export by inducing the internalization and degradatio | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $88,164 | Grant | Trans-NIH Recovery Act Research Support: While bariatric surgery is one of few effective long-term treatments for obesity, it is neither risk-free nor universally effective. The costs associated with surgery and publicity surrounding surgery-related deaths and complications have left many clinic | Health and Human Services, Department of / National Institutes of Health | 7/30/2009 |
| UNIVERISTY OF MISSISSIPPI MEDICAL CENTER | $124,922 | Grant | Trans-NIH Recovery Act Research Support: The prevailing paradigm regarding the relationship of angiotensin II (AngII) and renal injury is that AngII is uniformly injurious to the kidney. Our recent studies have found that a chronic infusion of subpressor doses of AngII (SP-AngII) has an unexpec | Health and Human Services, Department of / National Institutes of Health | 8/18/2009 |
| DUKE UNIVERSITY | $12,808 | Grant | Trans-NIH Recovery Act Research Support: We have previously identified a point mutation in thes Transient Receptor Potential Cation Channel 6 (TRPC6) gene causing an autosomal dominant form of familial focal and segmental glomerulosclerosis (FSGS). This P112Q substitution causes a marked alterat | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY OF MARYLAND | $55,800 | Grant | Trans-NIH Recovery Act Research Support: The results from this project will provide new mechanistic insights into heme transport in humans and may aid in the development of heme-based nutritional interventions for human iron deficiency. Identifying how heme-iron is acquired by humans and parasi | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF UTAH, THE | $430,823 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This application is in response to Notice Number NOT-OD-09-058: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications, and represents an expansion of our currently funded grant: 5R0 | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $95,747 | Grant | Trans-NIH Recovery Act Research Support: The requested supplement was to support ongoing research into the effect of glucocorticoids on skeletal muscle structure and function. Many diseases, including diabetes and various cancers, are associated with severe muscle wasting in conjunction with ele | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| PURDUE UNIVERSITY | $17,721 | Grant | Trans-NIH Recovery Act Research Support: Obesity has become a major public health problem worldwide such .that in developed countries 10-20% of the adult population is obese. As the rates of obesity rise, so do associated health care costs. Few effective approaches for reducing body weight exist | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| EMORY UNIVERSITY | $65,947 | Grant | Trans-NIH Recovery Act Research Support: ADMINISTRATIVE SUPPLEMENT FOR ENHANCING THE EFFECTIVENES OF A CULTURALLY SENSITIVE ORGAN DONATION INTERVENTION This Phase II randomized effectiveness trial utilizes a 2x2 simple factorial design with four conditions: (a) Enhanced DVD shown in a group sett | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| CHILDRENS HOSPITAL OF PHILADELPHIA | $22,109 | Grant | Trans-NIH Recovery Act Research Support: The control of gene expression is at the core of biological development and homeostasis. In recent years, an unexpected form of gene regulation has been discovered in which small RNA molecules known as microRNAs (miRNAs) repress the expression of target g | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| UNIVERSITY OF CINCINNATI | $46,042 | Grant | Trans-NIH Recovery Act Research Support: A number of diseases affecting the gastrointestinal tract are characterized by the dysregulation of ion and fluid transport resulting in diarrhea or constipation. Over the past fifty years, a plethora of studies have focused on possible mechanisms and tre | Health and Human Services, Department of / National Institutes of Health | 8/21/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $39,326 | Grant | Trans-NIH Recovery Act Research Support: CD48 is a member of the SLAM/CD2 family of leukocyte cell surface regulatory molecules whose gene is located within the lupus-associated Sle1b region of mouse chromosome 1. C57BL/6 (B6) mice with genetic ablation of CD48 (B6.CD48-/-) develop autoimmunity | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CINCINNATI | $35,846 | Grant | Trans-NIH Recovery Act Research Support: DMT1 is a widely-expressed iron transporter that is essential for adequate intestinal absorption of iron and for transport of iron in red blood cell precursors for the production of hemoglobin. Rare mutations in DMT1 cause severe microcytic anemia. Conver | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF FLORIDA | $67,839 | Grant | Trans-NIH Recovery Act Research Support: Disturbances of iron metabolism increase morbidity and mortality and are among the most common disorders affecting humans. Nearly 20% of women of reproductive age in the US are iron deficient, and iron overload is increasingly being recognized as a public | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| DUKE UNIVERSITY | $145,790 | Grant | Trans-NIH Recovery Act Research Support: Primary Hyperoxaluria type I (PH1) is a severe kidney stone disease caused by deficiency of the protein alanine: glyoxylate aminotransferase (AGT). In many patients, deficiency of AGT results from missense mutations that decrease the stability of this enz | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $22,512 | Grant | Trans-NIH Recovery Act Research Support: This grant provided a summer research experience(s) for __three____ (insert X number of high school student(s) college student(s) science educator(s) etc.) in health-related scientific research. | Health and Human Services, Department of / National Institutes of Health | 6/16/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $35,032 | Grant | Trans-NIH Recovery Act Research Support: We propose to continue our multiscale mechanical analysis of bioengineered tissues. In the current grant, we have used our two-scale model, in which the microscopic scale represents the collagen fiber network, and the macroscopic scale represents the tiss | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $118,400 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): BioMEMS (Biological-MicroElectroMechanical Systems) are seen as the next generation platform for performing many different biologically-based assays in areas such as drug discovery, due to their potential for providing | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | $354,754 | Grant | Trans-NIH Recovery Act Research Support: The goal of the current grant is to understand the role of ribbon synapses in communicating visual information in the retina. Visual signals originate in the photoreceptor cells, which then communicate with second-order bipolar neurons via ribbon synapses | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF WASHINGTON | $193,135 | Grant | Trans-NIH Recovery Act Research Support: This is a request for supplementary funds to support the appointment of an additional Research Scientist and obtain new instrumentation to expand the library of constructs for investigation of protein aggregation disease in vivo. While it is well known t | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $337,824 | Grant | Trans-NIH Recovery Act Research Support: This supplement will allow us to greatly enhance the pace of the work on the specific aims supported by the parent grant. Specifically, we will complete the transcriptome and proteome, and develop an initial interactome of neuroprotectin D1 (NPD1); define | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| NEW YORK UNIVERSITY | $261,373 | Grant | Trans-NIH Recovery Act Research Support: This supplement provides project support, both for technical personnel and equipment, to accelerate the pace of the research. The goals of this work are to understand the origins of amblyopia, a developmental disorder of vision, and to evaluate new stra | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $322,270 | Grant | Trans-NIH Recovery Act Research Support: Specifically we will use these additional resources to (1) define the molecular function of a protein domain, which can prevent degradation of ubiquitinated proteins and thus transmit the non-proteolytic ubiquitinsignal. (2) To understand how a protein th | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| HEALTH RESEARCH, INC. | $71,546 | Grant | Trans-NIH Recovery Act Research Support: The parent grant, ?Molecular Structure and Function of the Human Kinetochore Outer Plate?, funds efforts to determine the structure of the human kinetochore in order to better understand how it functions. The human kinetochore performs several tasks that | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| THE VANDERBILT UNIVERSITY | $85,525 | Grant | Trans-NIH Recovery Act Research Support: We have a bioluminescence monitoring apparatus that assays the circadian bioluminescence rhythms of cyanobacteria and is absolutely essential for Specific Aims D?2 and D?3 and to a lesser extent, Aim D?1 of our grant. This apparatus was constructed in 199 | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $63,953 | Grant | Trans-NIH Recovery Act Research Support: We requested funds to obtain an instrument that will allow us to accomplish the same goals described in the parent grant in more than 20-fold less time resulting in a significant acceleration of the pace of our scientific research. This request should als | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| OHIO STATE UNIVERSITY, THE | $98,901 | Grant | Trans-NIH Recovery Act Research Support: E. coli RecA protein promotes the central DNA strand-exchange step of homologous recombination, a fundamental process in all cells for the repair of double-stranded DNA breaks and other types of DNA lesions. RecA (Mr 38 kDa) is an ATPase that polymerizes | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $376,728 | Grant | Trans-NIH Recovery Act Research Support: The aims of the parent grant, R01 GM068061, are to elucidate the structures of bacterial single-stranded (ss) DNA-binding proteins (SSBs) cooperatively bound to ssDNA, to reveal how enzymes take advantage of direct binding to SSB to process ssDNA/SSB subs | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $315,963 | Grant | Trans-NIH Recovery Act Research Support: Neurospora crassa, which has one of the best understood systems in clock function and light entrainment, offers an excellent experimentally-accessible paradigm for undertanding the clock mechanism. These studies will help us to describe the molecular and | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $293,334 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this supplement was to accelerate our research and provide for continuity toward accomplishing the final aim of our parent R01 grant ?Genetic architecture of Hsp90-buffered variation?. Specifically, the purpose of this fund was to: 1) | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| DUKE UNIVERSITY | $46,841 | Grant | Trans-NIH Recovery Act Research Support: The goal of this research project is to test key organizational and functional aspects of centromeres. Centromeres are critical for chromosome segregation, as they are the site of kinetochore formation and mediate chromosome movements during mitosis and m | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| DUKE UNIVERSITY | $285,957 | Grant | Trans-NIH Recovery Act Research Support: Innate immune mechanisms are conserved in evolution. The NPR1 protein of Arabidopsis is a master regulator of gene expression in plant defense. Similar to the mammalian immuno- regulator NF-kB, the NPR1 protein is nuclear translocated upon induction. In t | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| MAYO CLINIC | $343,063 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of our research is to understand the anatomic and biochemical factors that control aquaeous outflow resistance in the normal eye, and the pathophysiologic changes that occur in glaucomatous eyes. We hypothesized in R01-EY07065 (funding | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $385,000 | Grant | Trans-NIH Recovery Act Research Support: The goal of this administrative supplement for infrastructure support is to increase the tempo of research and expand the scope of work related to all the Specific Aims of the parent grant, Regulation of pHi and Fluid Flux in Corneal Endothelium, by repla | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| THE VANDERBILT UNIVERSITY | $469,261 | Grant | Trans-NIH Recovery Act Research Support: This supplement is requested to enhance the accomplishment of the aims of the parent grant and extend our ability to investigate new questions. This will be achieved by: (1) hiring a new research assistant who will increase our capacity to obtain behavio | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CHICAGO, THE | $174,174 | Grant | Trans-NIH Recovery Act Research Support: This competitive revision application seeks additional funding for new aims that are being proposed for original grant application RO1EY10343. The original application sought funds to further our studies of the mechanisms of ischemic preconditioning (IPC) | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC. | $8,262 | Grant | Trans-NIH Recovery Act Research Support: Visual opsins maintain a weak, constitutive activity that can be modulated pharmacologically. Retinoids, including the truncated analog, b-ionone, increase the activity of opsins of rods and the opsins of all cones except the red-sensitive one. The abilit | Health and Human Services, Department of / National Institutes of Health | 6/30/2009 |
| THE JACKSON LABORATORY | $758,553 | Grant | Trans-NIH Recovery Act Research Support: The goal of this supplement is to utilize next generation sequencing technologies to identify novel, human glaucoma genes and identify valuable mouse mutations for studying glaucoma. Major goals of my parental R01 (EY011721) are to provide new mouse glauc | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $156,000 | Grant | Trans-NIH Recovery Act Research Support: This supplement award is to support a person for one year, to work on providing test equipment that will allow complete evaluation of the new x-ray tube that is being designed in the parent grant. In the parent grant proposal, we planned to use a previous | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $113,454 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Improvements in the treatment of brain tumors have produced little impact on outcomes over the past three decades. We propose the development of targeted, multifunctional nanoparticles designed to improve the survival | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| RIVERSIDE RESEARCH INSTITUTE | $255,988 | Grant | Trans-NIH Recovery Act Research Support: The goal of this study is to develop and evaluate advanced annular-array transducer technology for rapid, high-definition imaging in significant medical-research applications. The study will assess high frequency ultrasound (HFU, = 20 MHz) annular arrays | Health and Human Services, Department of / National Institutes of Health | 7/30/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $38,672 | Grant | Trans-NIH Recovery Act Research Support: Contrast agents play an important role in clinical magnetic resonance imaging (MRI). About one third of scans employ a contrast agent and these agents are almost exclusively gadolinium (Gd) based T1 agents that provide positive image contrast. Recently, h | Health and Human Services, Department of / National Institutes of Health | 6/16/2009 |
| HEALTH RESEARCH, INC. | $99,249 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The long-term objective is to determine the impact of environmental toxicants on the peripheral and central olfactory tissues, and the role of xenobiotic exposure in the etiology of anosmia and other diseases concernin | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $337,525 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Transcription factors play essential roles in the processes of neuronal cell fate determination and expression of the mature neuronal phenotype that are necessary for normal development and function of the brain. My la | Health and Human Services, Department of / National Institutes of Health | 8/15/2009 |
| DUKE UNIVERSITY | $154,434 | Grant | Trans-NIH Recovery Act Research Support: The overarching goal of the parent project was to identify lifestyle factors and potential epigenetic mechanisms associated with rapid growth and subsequent obesity in early childhood. Epigenetic factors are mitotically heritable information that controls | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| FLORIDA ATLANTIC UNIVERSITY | $189,788 | Grant | Trans-NIH Recovery Act Research Support: Award Title G?? Molecular Analysis of Microdissected Human Lenses. This supplement will determine the key molecular requirements for Methionine Sulfoxide reductase (MsrA) repair of alpha-crystallin chaperone activity. It will provide data that will esta | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| CALIFORNIA INSTITUTE OF TECHNOLOGY | $310,254 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this application is to explore how high level planning signals can be used for control of neural prosthetics to assist paralyzed patients. This study has both scientific and engineering components. The scientific investigations entail expl | Health and Human Services, Department of / National Institutes of Health | 9/02/2009 |
| OAKLAND UNIVERSITY | $15,700 | Grant | Trans-NIH Recovery Act Research Support: This award provided a summer research experience for three students in health-related scientific research. Throughout development, and in the mature retina, precise control of gene expression is essential for photoreceptor integrity and function. This in | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| ST. JUDE CHILDREN'S RESEARCH HOSPITAL | $313,663 | Grant | Trans-NIH Recovery Act Research Support: During retinal development, the decision to exit the cell cycle must be precisely coordinated with cell fate specification and differentiation to ensure that the correct proportion of each cell type is generated. The Rb family of proteins (Rb, p107 and p1 | Health and Human Services, Department of / National Institutes of Health | 8/19/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $75,865 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Iris contour is critical in angle-closure, pigment dispersion syndrome, and pigmentary glaucoma. Although many studies have examined iris contour under various conditions, the basic mechanical interactions between the | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF OKLAHOMA | $366,250 | Grant | Trans-NIH Recovery Act Research Support: Neurological cytokines have shown tremendous therapeutic potential for preventing or delaying neurodegenerations, including those causing retinitis pigmentosa and dry macular degeneration. The broad-spectrum protective activity of leukemia inhibitory fact | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $121,236 | Grant | Trans-NIH Recovery Act Research Support: This project examines the neural basis of spatial navigation, distinguishing between visual and nonvisual (amodal) spatial codes. This knowledge is critical for development of rehabilitation strategies in the blind. In particular, further characterizat | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $585,891 | Grant | Trans-NIH Recovery Act Research Support: This proposal describes an innovative nutritional/pharmacological strategy to prevent proliferative retinopathy in a mouse model of disease with the expectation of a later clinicaltrial of patients with diabetic retinopathy(DR). DR has inflammatory and an | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | $196,605 | Grant | Trans-NIH Recovery Act Research Support: During rapid eye movements, we are not aware of the motion of the retinal image, nor do we perceive the world to be in a different place after every eye movement. This shows that, somehow, the brain corrects for the movement of the eyes when translating t | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $96,755 | Grant | Trans-NIH Recovery Act Research Support: The transport of proteins inside ciliary axoneme is essential for cilia formation, maintenance, and function. It is referred to as the intraflagellar transport (IFT). This mechanism involves a group of proteins that associate together, forming so-called | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CONNECTICUT | $260,249 | Grant | Trans-NIH Recovery Act Research Support: The proposed work aims to understand early cortical mechanisms of vision in alert and in non-alert subjects. Thanks to the development of behavioral methods for the control of eye position, great advances have been made in understanding central mechanisms | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $115,250 | Grant | Trans-NIH Recovery Act Research Support: A residue level visualization of protein structures changing with time through associated water in transmembrane (TM) helices, proton channels, fast folding proteins, reverse transcriptase inhibitors and fibrils will be obtained by two dimensional infrare | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF OREGON | $120,789 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement to our parent NIH grant will permit us to extend and speed up certain aspects of our ongoing work on the structure, function and control of DNA replication and transcription complexes. The additional work described and fundi | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $183,263 | Grant | Trans-NIH Recovery Act Research Support: The long-term objective of this project has been to understand as fully and as deeply as possible, the principles governing the action of the regulatory protein AraC of the L-arabinose operon in the bacterium Escherichia coli and to expand these to elucid | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| CORNELL UNIVERSITY, INC | $106,081 | Grant | Trans-NIH Recovery Act Research Support: We aim to conduct genome-wide global run-on and sequencing (GRO-seq) analysis to characterize promoter architecture and nascent transcription activity at a high resolution in induced pluripotent stem cells (iPS) derived from non-embryonic sources. We hav | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $369,050 | Grant | Trans-NIH Recovery Act Research Support: We propose that the recruitment of endothelial progenitor cells and activation of anti-inflammatory signaling pathways are the mechanisms by which SDF-1a is beneficial in sepsis. 1. We will determine the effect of CTCE-0214 on the cecal ligation and punct | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF MASSACHUSETTS | $186,599 | Grant | Trans-NIH Recovery Act Research Support: We will conduct two studies that will serve to improve and enable the accomplishment of the specific aims of 5R01 GM030758: 28-29. The first addresses time and data loss due to human cells migrating off the fields of view during the time lapse observati | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $50,345 | Grant | Trans-NIH Recovery Act Research Support: Accurate segregation of duplicated chromosomes ensures that daughter cells get one and only one copy of each chromosome. Errors in chromosome segregation result in aneuploidy and have severe consequences on human health. Incorrect chromosome number and ch | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $228,959 | Grant | Trans-NIH Recovery Act Research Support: This supplement is a request to accelerate and extend the first two aims of the parent project. The production, purification and labeling of TonS dependent transporters is the most labor intensive aspect of the current project, and ongoing work to measure | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $155,703 | Grant | Trans-NIH Recovery Act Research Support: The Flp ('flip') site-specific recombinase is coded for by the 2 micron circle yeast plasmid. Two key pre- chemical steps in combination are: (1) recognition of the target DNA site by Flp and (2) establishing a functional dimer interface between Flp neigh | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| UNIVERSITY OF ROCHESTER | $177,592 | Grant | Trans-NIH Recovery Act Research Support: This supplement allows us to access new imaging technology to characterize the dendritic cell intra-cellular altered signaling and receptor co localization which contribute to post injury pathology. -?A new post doctorial fellow position, training in this | Health and Human Services, Department of / National Institutes of Health | 9/08/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $166,577 | Grant | Trans-NIH Recovery Act Research Support: Muscle wasting remains a cause of morbidity and mortality after trauma, burns and infection. Although the mechanisms for the atrophic response are multifactorial and poorly defined, our work documents the causal relationship between the up regulation of i | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $79,595 | Grant | Trans-NIH Recovery Act Research Support: Signaling from G protein-coupled chemoanraetant receptors to the various functional responses of human leukocytes involves Rho small GTPases. P21activated kinases (PAKs) are important downstream mediators of Rho GTPase signaling that regulate crosstalk be | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| PURDUE UNIVERSITY | $162,183 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION: The major goal of this study is to increase our understanding, in terms of structure and dynamics, of the molecular mechanisms that regulate protein function in cellular signal transduction. Signaling pathways comprise numerous protein-protei | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF CONNECTICUT | $170,880 | Grant | Trans-NIH Recovery Act Research Support: Cell shape, polarity and motility are controlled by the actin cytoskeleton. How F-actin filaments are assembled into functional arrays is still poorly understood. There are numerous F-actin binding proteins that are capable of cross-linking actin filament | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| TEMPLE UNIVERSITY | $138,043 | Grant | Trans-NIH Recovery Act Research Support: The Klein group proposes supplemental study to accelerate the tempo of scientific research on biological membranes. This research will extend our understanding of the role of proteins (fusion peptides) in facilitating membrane fusion, a key process in tri | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |