Listing all stimulus spending by amount, in descending order. Return to National Institutes of Health page
Amount refers to both the amount of stimulus funding going toward the project and the face value of the loan.
| Recipient | Amount | Type | Description | Federal Dept./Agency | Date |
|---|---|---|---|---|---|
| NEW YORK UNIVERSITY (INC) | $2,325,498 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Poorly controlled hypertension (HTN) remains one of the most significant public health problems in the United States, in terms of morbidity, mortality, and economic burden. Despite compelling evidence supporting the be | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| GEORGIA TECH RESEARCH CORPORATION | $775,872 | Grant | Trans-NIH Recovery Act Research Support: Approximately 7.9 million Americans suffer from heart failure every year. Among these, nearly 2.5 million develop Ischemic Mitral Regurgitation (IMR), a 33% increase since 1995. Even with such high prevalence, little is known of the cause and progression | Health and Human Services, Department of / National Institutes of Health | 8/12/2009 |
| UNIVERSITY OF FLORIDA | $824,838 | Grant | Trans-NIH Recovery Act Research Support: Specifically, the goals of this proposal are 1) to determine whether aging results in uncoupling of eNOS and reduction of bioavailable NO in skeletal muscle resistance arteries, and 2) to determine whether interventional strategies, including aerobic exer | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $1,057,152 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this research project is to study the role of AIF in cardiac apoptosis. Although the caspases are thought to be central mediators of the apoptotic program, our preliminary studies have demonstrated that adult cardiomyocytes are both | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| TEXAS AGRILIFE RESEARCH | $883,345 | Grant | Trans-NIH Recovery Act Research Support: Continuation-A major contributor to morbidity and mortality in trauma patients following emergency resuscitation is intestinal dysfunction caused by interstitial edema formation in the bowel. The mesenteric lymphatic system plays a crucial role in limiti | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $1,197,834 | Grant | Trans-NIH Recovery Act Research Support: The majority of diseases potentially amenable to gene-based therapeutic approaches will likely require systemic vector administration, especially those with vascular involvement such as metastatic cancer, pulmonary arterial hypertension (PAH) and various | Health and Human Services, Department of / National Institutes of Health | 5/30/2009 |
| DUKE UNIVERSITY | $793,292 | Grant | Trans-NIH Recovery Act Research Support: This proposal, entitled ICD Therapy in Patients with Congestive Heart Failure, examines the current use of primary prevention implantable cardioverter defibrillator (ICD) in clinical practice. Although randomized clinical trials have established the ICD a | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $765,515 | Grant | Trans-NIH Recovery Act Research Support: The human cutaneous circulation is an accessible, representative vascular bed for in vivo examination of mechanisms that contribute to vascular dysfunction with essential hypertension (HT). This proposal is a logical extension of our previous work investi | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $1,474,445 | Grant | Trans-NIH Recovery Act Research Support: The primary aim of the proposed study is to explore how the familial and home environment of adolescents is related to adolescent weight-related outcomes. We will examine parental reports of the weight culture (e.g., dieting and weight norms) and food and | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| UNIVERSITY OF PITTSBURGH THE | $757,500 | Grant | Trans-NIH Recovery Act Research Support: Irradiation Damage and Protection of Pulmonary Endothelium Oxidative Lipidomics Radiation exposure leads to the development of severe acute inflammatory response and late damage to the lung culminating in delayed fibrosis. Pulmonary endothelium is the loc | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $737,500 | Grant | Trans-NIH Recovery Act Research Support: After biosynthesis within the fibroblast, a procollagen molecule is secreted into the extracellular space where it must undergo a series of very ordered, time sensitive, and location sensitive sequential post-synthetic processing steps in order to become | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $824,952 | Grant | Trans-NIH Recovery Act Research Support: COAGULATION ACTIVATION IN SICKLE CELL DISEASE ARRA: This study seeks to further define the contribution of coagulation activation to the pathogenesis of sickle cell disease-associated pulmonary hypertension. Patients in the clinical study will be randomiz | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $691,110 | Grant | Trans-NIH Recovery Act Research Support: During embryogenesis, the heart develops functional left-right (LR) asymmetries. Perturbation of cardiac LR asymmetry, or laterality, often leads to complex congenital heart defects. There is strong evidence that ciliated cells play a role in establishing | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| DUKE UNIVERSITY | $1,513,285 | Grant | Trans-NIH Recovery Act Research Support: Coronary artery disease (CAD) is the leading cause of the death in the US and, in concert with the epidemic of obesity and diabetes, is becoming the leading cause of death in many developing countries. The genetic predilection of CAD is well-established. | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $2,828,090 | Grant | Trans-NIH Recovery Act Research Support: This application proposes to study a large cohort of children with autism using a multidisciplinary analytic approach in order to identify biological signatures that define distinct phenotypes of autism. We propose that subtypes will be identifiable on th | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| THE WASHINGTON UNIVERSITY | $0 | Grant | Trans-NIH Recovery Act Research Support: Prion diseases are fatal neurodegenerative disorders of humans and animals. They result from conversion of PrPC, a normal membrane glycoprotein into PrPSc, a conformationally altered isoform that is infectious in the absence of nucleic acid. Most exogenou | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| BAYLOR COLLEGE OF MEDICINE | $1,084,524 | Grant | Trans-NIH Recovery Act Research Support: The relevance to public health is that the project will enhance our understanding and provide new insights into mechanisms for chromosomal abnormalities that result from nonrecurrent rearrangements. Such genome rearrangements cause gene copy number change | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| SALK INSTITUTE FOR BIOLOGICAL STUDIES,THE | $1,637,015 | Grant | Trans-NIH Recovery Act Research Support: Stroke is a major cause of death throughout the world and its prevalence is increasing with increased longevity and obesity-associated vascular disease. There are, however, very few effective therapeutics. During the last few years we have identified a br | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $856,435 | Grant | Trans-NIH Recovery Act Research Support: Rapid eye movement (REM) sleep is a behavioral state characterized by activation of the cortical and hippocampal EEG, rapid eye movements and muscle atonia. While some progress has been made in recent years in the effort to delineate 1) the locus of the p | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| MARQUETTE UNIVERSITY | $772,692 | Grant | Trans-NIH Recovery Act Research Support: The objective of this study is to identify how the suppression of reflex function by antispastic agents affects volitional movement in people with incomplete spinal cord injury (SCI). Spastic reflexes are commonly treated using medications or other therap | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $762,750 | Grant | Trans-NIH Recovery Act Research Support: Neurodegeneration associated with brain iron accu ulation (N BIA) comprises a heterogeneous group of disorders, such as infantile neuroaxoal dystroph (INAD), in which disruption of cellular mechanisms leads to accumulation of iron in the b sal ganglia. Th | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $866,606 | Grant | Trans-NIH Recovery Act Research Support: Injuries to the brachial plexus result in the reduction or loss of use of the upper extremities due to damage to the brachial nerves and/or spinal roots. These injuries are usually the result of vehicle accidents or falls. Peripheral nerve grafts have b | Health and Human Services, Department of / National Institutes of Health | 7/19/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO | $787,560 | Grant | Trans-NIH Recovery Act Research Support: A-kinase anchoring proteins (AKAPs) organize numerous intracellular signaling pathways by bringing together their molecular components into discrete sub-cellular microdomains. One such AKAP, AKAP79/150 interacts with protein kinase A, protein kinase C (PK | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| THE UNIVERSITY OF SOUTH DAKOTA | $117,670 | Grant | Trans-NIH Recovery Act Research Support: Incidences of heart diseases are increased with age and cardiac diastolic dysfunction and diastolic heart failure are more often found in the elderly. This study is to investigate whether chronic left vagus nerve stimulation (CLVNS) can improve ventricula | Health and Human Services, Department of / National Institutes of Health | 4/30/2009 |
| ETUBICS CORP | $109,056 | Grant | Trans-NIH Recovery Act Research Support: Project is designed to evaluate the cell-mediated immune (CMI) response in non-human primates that have been immunized against SIV Gag, Pol, Nef. Specifically, we will perform ELISpot and cytometric flow separation studies to determine the level of CMI an | Health and Human Services, Department of / National Institutes of Health | 8/15/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $115,260 | Grant | Trans-NIH Recovery Act Research Support: The maturation of dendritic cells (DCs) in response to a pathogen is essential for effective immune-mediated control of the infection and protection from subsequent re-infections. Pathogenic viruses have developed strategies to evade immune recognition by | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| FOX CHASE CANCER CENTER | $174,459 | Grant | Trans-NIH Recovery Act Research Support: The incidence of esophageal adenocarcinoma (EAC) in the United States is increasing markedly. Five-year survival remains a disappointing 15%. Better methods are urgently needed to detect patients at high risk of EAC and to interrupt disease progression. I | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| RENSSELAER POLYTECHNIC INSTITUTE | $130,945 | Grant | Trans-NIH Recovery Act Research Support: Circadian disruption has been implicated as a significant contributor to the increasing incidence of many modern maladies such as breast cancer. Proposed here is a small, sophisticated study of the absolute and spectral sensitivities of two strains of rat | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $189,800 | Grant | Trans-NIH Recovery Act Research Support: The overall aim of the proposed research is to identify the neural substrates of impulsive decision making associated with chronic exposure to drugs of abuse. Such information is potentially important for understanding the development and cessation of hab | Health and Human Services, Department of / National Institutes of Health | 5/04/2009 |
| SOUTH CAROLINA RESEARCH FOUNDATION | $144,000 | Grant | Trans-NIH Recovery Act Research Support: ROLE OF DARPP-32: INDIVIDUAL RESPONSIVENESS TO NICOTINE Tobacco use is the number one preventable cause of death in the world. Nicotine (NIC), the most abundant alkaloid in tobacco, is the primary reinforcing agent in tobacco smoking. Many factors contrib | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| WEST CHESTER UNIVERSITY OF PENNSYLVANIA | $73,500 | Grant | Trans-NIH Recovery Act Research Support: The discovery of compounds capable of preventing cocaine?s harmful properties with minimal physiological effects is a promising area of research. Cocaine abuse is intensively studied; however, there are no proven pharmacological treatments for cocaine ad | Health and Human Services, Department of / National Institutes of Health | 5/04/2009 |
| DUKE UNIVERSITY | $391,250 | Grant | Trans-NIH Recovery Act Research Support: Methamphetamine (METH) addiction is a global problem, and has now reached epidemic proportions in certain Western, Midwestern, and Southern states including North Carolina. Total abstinence from METH is very difficult to achieve in the clinic, mainly beca | Health and Human Services, Department of / National Institutes of Health | 5/04/2009 |
| MCLEAN HOSPITAL CORPORATION, THE | $158,000 | Grant | Trans-NIH Recovery Act Research Support: Human genetic studies have linked genes encoding GABAA receptor ? subunits to mental illnesses like major depression, bipolar disorder, schizophrenia, alcohol dependence, and illicit drug dependence. However, the functions of the products of these genes w | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF ILLINOIS | $246,743 | Grant | Trans-NIH Recovery Act Research Support: This A-START application proposes formative research aimed at understanding the role of illicit drugs in the transmission dynamics of sexually transmitted infections (STIs) and HIV among 18-30 year old African Americans (AA) living in high-risk neighborho | Health and Human Services, Department of / National Institutes of Health | 5/04/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $984,470 | Grant | Trans-NIH Recovery Act Research Support: Chronic obstructive pulmonary disease (COPD) includes both emphysema and small airway disease. COPD has typically been defined based on a reduction in the FEV1/FVC ratio, with the severity of COPD determined by the level of reduction in the FEV1. However, | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $999,999 | Grant | Trans-NIH Recovery Act Research Support: Micro RNA Regulation of Human Airway Epithelial Phenotype G?? ARRA Greater than (<) 22 million people in the USA currently have asthma and <15 million people have chronic obstructive pulmonary disease. Along with less common obstructive lung diseases s | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $975,651 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (15) Translational Research and specific Challenge Topic 15-OD(ORDR)-101: Pilot projects for prevention, early detection and treatment of rare diseases. This Challenge Grant application is focused on arrhyth | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $998,684 | Grant | Trans-NIH Recovery Act Research Support: This application, 'Epigenetic Biomarkers of Common Chronic Diseases,' addresses broad Challenge Area (03) Biomarker Discovery and Validation and specific Challenge Topic, 03-OD-101: Use of Epigenetic Signatures in Blood Cells to Predict Disease. Diabetes, | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| TUFTS MEDICAL CENTER PARENT, INC. | $991,426 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area 04, Clinical Research, and Specific Challenge Topic 04-HL-114, Using existing datasets to plan effectiveness trials in pediatric cardiology. This challenge topic specifically identifies a critical need for | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| GROUP HEALTH COOPERATIVE | $986,250 | Grant | Trans-NIH Recovery Act Research Support: Overweight and obese adults are more likely to have hypertension and other risk factors for cardiovascular disease (CVD). Evidence-based medication and lifestyle strategies can be used to decrease CVD risk, but little is known about the comparative effec | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $995,031 | Grant | Trans-NIH Recovery Act Research Support: The assessment of proper and effective ventilatory function in premature newborns suffering from respiratory distress secondary to surfactant deficiency is difficult, and only crude measures are currently available. In part this arises from the delicate a | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| SEATTLE INSTITUTE FOR CARDIAC RESEARCH | $999,931 | Grant | Trans-NIH Recovery Act Research Support: This award is issued under the American Recovery and Reinvestment Act of 2009 and is subject to special HHS terms and conditions as referenced in Section III. | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $966,238 | Grant | Trans-NIH Recovery Act Research Support: Pilot Studies of Gene Therapy for Primary Ciliary Dyskinesia - ARRA The long-term goal of this research is to develop gene therapy as a treatment for the rare disease Primary Ciliary Dyskinesia (PCD). PCD is predominantly inherited as an autosomal reces | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| SAN DIEGO STATE UNIVERSITY FOUNDATION | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: This project addresses how to develop cell-based therapies for cardiovascular, lung and blood diseases. The specific aims are 1) Assess long term persistence characteristics of Pim-1 engineered stem cells in promotion of myocardial repair and regeneration | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $994,862 | Grant | Trans-NIH Recovery Act Research Support: The proposed application under this challenge grant seek to answer the following questions: (1) What is the incremental cost-effectiveness of SPECT, PET, and CCTA as well as their respective accuracy for identification of obstructive CAD, and clinical eve | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $995,436 | Grant | Trans-NIH Recovery Act Research Support: This proposed study plans to enhance and evaluate IT infrastructure developed to provide timely genetic variant updates and patient search functionality to clinicians to assist in optimizing patient care. Partners HealthCare has deployed and is continuing | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $629,215 | Grant | Trans-NIH Recovery Act Research Support: This project addresses the Challenge Area 15: Translational Science. The Challenge Topic is 15-TW- 101: Models to predict health effects of climate change. The slow but steady increase in the global mean temperature as a result of climate change is bringi | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $495,600 | Grant | Trans-NIH Recovery Act Research Support: Overall purpose: to determine whether cancer diagnosis is an influence on personal bankruptcy. Deliverables: a. Linkage of Western Washington Bankruptcy Court records to cancer records in the National Cancer Institute?s Surveillance, Epidemiology, and | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $875,007 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (09) Health Disparities and specific Challenge Topic 09-MD- 102 Trans-disciplinary Research to Integrate the Biological and Non-biological Determinants of Health to Address Health Disparities. Description 'B | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF MIAMI | $947,328 | Grant | Trans-NIH Recovery Act Research Support: Although the development of new therapeutic modalities against CVD has reduced overall CVD mortality by nearly 50%, the gap between certain minority groups and non-minority groups has not diminished. There is preliminary evidence, including our own, that | Health and Human Services, Department of / National Institutes of Health | 9/20/2009 |
| CHILDRENS HOSPITAL OF PHILADELPHIA | $812,955 | Grant | Trans-NIH Recovery Act Research Support: This application responds to broad challenge grant area (04): Clinical Research & specific Challenge Topic, 04-MD-101: Enhancing Recruitment & Retention of Ethnic Minorities in Clinical Trials. Sickle cell disease (SCD) is a genetic disorder affecting pri | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $999,891 | Grant | Trans-NIH Recovery Act Research Support: The Committee on Adolescent Health Care Services, the National Research Council, and the Institute of Medicine have identified adolescents with chronic disease as one of the ?most vulnerable? groups of adolescents. Studies to date demonstrate poor mental | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $999,920 | Grant | Trans-NIH Recovery Act Research Support: This grant responds to NIH Challenge 08-MH-103: Understanding the Genomic Risk Architecture of Mental Disorders. This application builds on recent animal and human data on epigenetic mechanisms mediating 'glucocorticoid programming' to address a critical | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| DUKE UNIVERSITY | $499,980 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (06) Enabling Technologies and specific Challenge Topic, 06-MH-102: Technologies to study neuronal signaling, plasticity, and neurodevelopment. The complex and diverse functions of the brain depend on the un | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF MASSACHUSETTS | $766,764 | Grant | Trans-NIH Recovery Act Research Support: Youth with mental health needs during the transition to adulthood have tremendously compromised functioning in working, living independently, and staying out of trouble with the law. Office-based mental health treatment is accessed by 760,000 transition a | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| CALIFORNIA INSTITUTE OF TECHNOLOGY | $656,259 | Grant | Trans-NIH Recovery Act Research Support: This project develops tools to address two hypotheses: first that specific types of neurons in localized brain regions or subregions can be altered so that they are susceptible to reversible inactivation or activation in response to systemically delivered | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $998,901 | Grant | Trans-NIH Recovery Act Research Support: This application addresses Broad Challenge Area 01 Behavior, Behavioral Change, and Prevention. The specific topic is: Capturing Social Network Information for Groups at High Risk for Negative Health Behaviors; OD-09-003. Latinos in the United States are | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| COLD SPRING HARBOR LABORATORY | $998,857 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (15): Translational Science and specific Challenge Topic,15- MH-103 Mapping the Neural Connectivity of a Mouse Model. Brain function is dictated by its circuitry, yet we know little about its wiring architec | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| COLD SPRING HARBOR LABORATORY | $1,012,457 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (08) Genomics and specific Challenge Topic, 08- MH-103: Understanding the genomic risk architecture of mental disorders. Rett syndrome (RTT), caused by mutations in the X-linked gene encoding methyl-CpG-bind | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $560,391 | Grant | Trans-NIH Recovery Act Research Support: This application addresses the broad Challenge Area (05) Comparative Effectiveness Research (CER) and the specific Challenge Topic (05-MH-102) Cost Effectiveness of Mental Health Interventions. This study will conduct comparative cost-effectiveness analy | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| MIND RESEARCH NETWORK, THE | $984,625 | Grant | Trans-NIH Recovery Act Research Support: The goal of this Challenge grant application is to identify novel biomarkers of clinical severity in patients with schizophrenia. The identification of such biomarkers will not only increase our knowledge of the pathophysiology of schizophrenia but also, | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF MASSACHUSETTS | $968,190 | Grant | Trans-NIH Recovery Act Research Support: The blurring of the distinction between treatment and research in the minds of participants in phase 3 clinical trials has been referred to as therapeutic misconception (TM). This has been widely recognized as a major problem for informed consent to resea | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $451,157 | Grant | Trans-NIH Recovery Act Research Support: Communication in Late-stage Cancer: Exploring Hospice Decisions This application addresses broad Challenge Area (04): Clinical Research and specific Challenge Topic, 04-NR-103*: Methods to Enhance Palliative Care and End-of-Life Research. Estimates indica | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | $194,176 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This proposal addresses Challenge Area 15: Translational Science, and Specific Challenge Topic: Demonstration of proof-of-concept for a new therapeutic approach in a neurological disease: 15-NS-103. Parkinson's disease | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| FLORIDA ATLANTIC UNIVERSITY | $1,380,696 | Grant | Trans-NIH Recovery Act Research Support: Natural products represent an excellent source of novel chemical scaffolds that are inherently biologically active. It has been estimated that 78% of the 90 antibacterial agents and 62% of the 79 anticancer agents approved for use in the US over the past | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | $2,352,573 | Grant | Trans-NIH Recovery Act Research Support: The 20% rarest cancers account for approximately 35% of the deaths from cancer in the United States. As a result, a better understanding of the nature of these rare tumors is in the public health's best interest. We study sarcomas, rare cancers of connect | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $3,866,878 | Grant | Trans-NIH Recovery Act Research Support: CYCORE: CYBERINFRASTRUCTURE FOR COMPARATIVE EFFECTIVENESS RESEARCH | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| WISTAR INSTITUTE OF ANATOMY & BIOLOGY | $991,151 | Grant | Trans-NIH Recovery Act Research Support: Epstein-Barr virus (EBV) infects over 95% of the adult population worldwide, and has been estimated to be a contributing agent in ~1% of all human cancer. Its carcinogenic potential is significantly elevated by immunosuppression, as is found in the conte | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $4,894,665 | Grant | Trans-NIH Recovery Act Research Support: Abstract this project aims to establish a Lung Cancer Mutation Consortium (LCMC) consisting of 13 institutions with a major interest in lung cancer and genomic testing of lung cancer as documented by having major NCI grants in lung cancer. The LCMC member | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| BAYLOR RESEARCH INSTITUTE, THE | $980,587 | Grant | Trans-NIH Recovery Act Research Support: In collaboration with scientists at the Unversity of Texas MD Anderson Cancer Center, we will test our immunotherapeutic approach to treating HPV related cancers in a non-human primate model. This study fulfills the premises of the Grand Opportunity Grant | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | $1,543,237 | Grant | Trans-NIH Recovery Act Research Support: This application, for a Research and Research Infrastructure 'Grand Opportunities' (GO) grant (RFA- OD-09-004) will focus on 'Comparative Oncology Research' and requests funds for a unique state of the art PET insert for an MR animal scanner which will be | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| ROCKEFELLER UNIVERSITY FACULTY AND STUDENTS CLUB INC, THE | $4,575,102 | Grant | Trans-NIH Recovery Act Research Support: Recent studies of addiction have highlighted several regions of the brain that are thought to be involved in goal directed and drug seeking behaviors. The specific neuronal classes involved in the regulation of these behaviors are beginning | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| MISSOURI SYSTEM, UNIVERSITY OF | $173,156 | Grant | Trans-NIH Recovery Act Research Support: This application is submitted in response to an RFA-OD-09-004 entitled 'Recovery Act Limited Competition for NIH Grants: Research and Research Infrastructure 'Grand Opportunities' (RC2)' and addresses the NIDCR Area of Scientific Priority 'Genome-wide Stu | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $1,214,675 | Grant | Trans-NIH Recovery Act Research Support: The purpose of the study is to evaluate the efficiency of a risk assessment algorithm in identifying subjects with suspicious pre-cancerous or cancerous lesions in high risk population, as compared to broad screening in the general population. To test the | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| DUKE UNIVERSITY | $997,347 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (04): Clinical Research and specific Challenge Topic 04-AG-107: Mechanisms of specific benefits of different types of physical activity. MECHANISMS AND FUNCTIONAL OUTCOMES OF EXERCISE PROGRESSION MODELS IN T | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $827,481 | Grant | Trans-NIH Recovery Act Research Support: The human malaria parasite, Plasmodium falciparum, possesses a broad repertoire of proteins that are proposed to be trafficked to the erythrocyte cytoplasm or surface, based upon the presence within these proteins of a signal peptide followed by a Pexel/H | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| TUFTS MEDICAL CENTER, INC. | $654,275 | Grant | Trans-NIH Recovery Act Research Support: Ndy1/KDM2B is an enzyme that functions as a regulator gene expression by modifying histone molecules. By repressing genes involved in cell differentiation, Ndy1/KDM2B contributes to the cycling of stem cells, and when deregulated, it contributes to the de | Health and Human Services, Department of / National Institutes of Health | 5/27/2009 |
| PACIFIC NORTHWEST RESEARCH INSTITUTE | $812,500 | Grant | Trans-NIH Recovery Act Research Support: The long-term objective of this research program is to understand how mutations in the ABCC8 gene that encodes the regulatory subunit of the neuroendocrine type ATP-sensitive potassium (KATP) channel, SUR1, cause neonatal diabetes (ND). The two specific a | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| UNIVERSITY OF NEBRASKA | $755,826 | Grant | Trans-NIH Recovery Act Research Support: A Computational Genotyping System for Improved Influenza Surveillance. The long-term goal of this research is to better understand how influenza A viruses evolv, spread, and cause disease, so that enhanced diagnoses and ultimately control strategies for i | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $493,094 | Grant | Trans-NIH Recovery Act Research Support: Replace an aged and energy inefficient tunnel cage washer and install a cooling/ventilation system. This will allow conversion of the clean side of an open-air facility to be enclosed to improve and maintain a high level of cage sanitation. | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF ROCHESTER | $647,680 | Grant | Trans-NIH Recovery Act Research Support: This proposal seeks to support a research program in the area of tissue engineering in the musculoskeletal sciences. It is aimed at enriching the infrastructure of a translational research partnership at the University of Rochester. The partnership is bet | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $1,632,174 | Grant | Trans-NIH Recovery Act Research Support: This Faculty Development Research Core will recruit Dr. Julius Birnbaum and Dr. Ami Shah to the tenure track faculty as Assistant Professors in the Division of Rheumatology at Johns Hopkins University. The Division of Rheumatology at Johns Hopkins is a hi | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| CHILDRENS HOSPITAL OF PHILADELPHIA | $822,500 | Grant | Trans-NIH Recovery Act Research Support: The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a multifunctional protein that transports chloride across the apical plasma membrane of epithelial cells. CFTR also regulates ion transport by other proteins, such as the Epithelial Sodium | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | $2,805,907 | Grant | Trans-NIH Recovery Act Research Support: Patient Reported Outcomes (PROs) are a necessary component of medical research and practice. The NIH-sponsored Patient-Reported Outcome Measurement Information System (PROMIS) has developed item banks and scales for several domains of symptoms and functi | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $865,671 | Grant | Trans-NIH Recovery Act Research Support: Broad spectrum anti-viral agents are being developed for the treatment of hemorrhagic fevers caused by use of arenaviruses as biological weapons. The new anti-viral agents are human antibodies that eliminate virally-infected cells and viruses, assisting i | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| UNIVERSITY OF ILLINOIS | $4,023,530 | Grant | Trans-NIH Recovery Act Research Support: No research with a Highly Pathogenic Agent or Select Agent has been performed or is planned to be performed under this grant. Surrogate strains with low pathogenicity will be used to evaluate such agents. Bacillus anthracis, Francisella tularensis and Y | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF MASSACHUSETTS | $821,456 | Grant | Trans-NIH Recovery Act Research Support: Our studies will elucidate molecular mechanisms that control cell division in osteoblasts, as a component of normal development and maintenance of bone tissue. Our studies focus on a transcription factor that is critical for bone formation in human and mo | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | $897,696 | Grant | Trans-NIH Recovery Act Research Support: Enzymes of the ubiquitin proteasome system (UPS) and their substrates are increasingly implicated in fundamental cellular processes, including cell proliferation, differentiation, transcriptional regulation, and stress response, amongst many others. With | Health and Human Services, Department of / National Institutes of Health | 9/08/2009 |
| THOMAS JEFFERSON UNIVERSITY | $772,500 | Grant | Trans-NIH Recovery Act Research Support: ?1-adrenergic receptors (?1ARs) generally do not couple to the adenylyl cyclase inhibitory heterotrimeric G protein, Gi, however, data in cultured cells indicate that phosphorylation of ?1ARs by GRK5 can allow for Gi-coupling due to GRK5 actions causing a | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $476,304 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this project is to provide high-quality animal care and housing that enhances the productivity of Oregon Health & Science University (OHSU)'s PHS-funded researchers. This proposal has two specific aims: 1) to expand the capacity of m | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $1,330,840 | Grant | Trans-NIH Recovery Act Research Support: This application is from the School of Dentistry (SOD) at the University of Alabama at Birmingham (UAB) in response to the NIDCR RFA-OD-09-005 titled Recovery Act Limited Competition: Supporting New Faculty Recruitment to Enhance Research Resources throug | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| NEW YORK UNIVERSITY | $1,493,804 | Grant | Trans-NIH Recovery Act Research Support: This is a P30 application to establish a Center in Craniofacial Bone Biology at New York University College of Dentistry (NYUCD). This will advance research into understanding important disease processes such as cleft palate and lead to strategies for the | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF TEXAS AT SAN ANTONIO | $633,500 | Grant | Trans-NIH Recovery Act Research Support: We propose to hire a new Assistant Professor in the area of Stem Cell Research, with a specific interest in either Neurological Stem Cell Biology or Mesesenchymal Stem cell Biology as an Investigator in the San Antonio Institute for Cellular and Molecular | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| THE VANDERBILT UNIVERSITY | $775,416 | Grant | Trans-NIH Recovery Act Research Support: Advances in molecular medicine, genomics, proteomics and bioinformatics have enhanced our understanding of inter-individual variability in susceptibility to disease, in expression of disease, and in beneficial and adverse responses to therapies. Vanderbil | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $1,287,252 | Grant | Trans-NIH Recovery Act Research Support: During the past quarter, we have made excellent progress in establishing Dr. Anwarul Ferdous as an independent investigator in the Division of Cardiology here at UT Southwestern Medical Center. He is swiftly establishing an independent program of researc | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $1,476,260 | Grant | Trans-NIH Recovery Act Research Support: This application is seeking support for a new Assistant Professor in the Center for Regenerative Medicine (CRM), at the Massachusetts General Hospital (MGH), Harvard Medical School. This individual will be located in recently completed laboratory and offi | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF KENTUCKY | $1,110,233 | Grant | Trans-NIH Recovery Act Research Support: T.his is a NIH P30 Biomedical Research Core Center Application (RFA-OD-09-005) on Fetal Programming in the Development of Obesity-induced Cardiovascular Diseases. The request is for support of salary and start-up costs for recruit of one new investigator | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF ILLINOIS | $1,406,101 | Grant | Trans-NIH Recovery Act Research Support: Protein disulfide isomerase in vascular diseases. The research interest of my laboratory is to understand the molecular mechanisms of vascular diseases such as thrombosis and inflammation. We are currently focusing on the role of protein disulfide isomera | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF UTAH, THE | $839,207 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Diabetes and obesity are major risk factors for cardiovascular disease, whose incidence is increasing in the United States at an alarming rate. There is an urgent need to increase our understanding of fundamental mecha | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF TOLEDO, THE | $1,249,871 | Grant | Trans-NIH Recovery Act Research Support: The overall purpose of the P30 award (RFA-OD-09-005) is to support the recruitment, laboratory startup, and career development of Viviana Ferreira, Ph.D., in the Department of Medical Microbiology and Immunology at the University of Toledo College of Medi | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF PITTSBURGH THE | $1,327,540 | Grant | Trans-NIH Recovery Act Research Support: The overarching goal of this P30 application is to enhance research capacity in the understanding and treatment of cardiovascular, pulmonary, and blood diseases, and other biomedical and translational research areas through the development of stem cell re | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF NEW MEXICO | $1,091,475 | Grant | Trans-NIH Recovery Act Research Support: The goal of this proposal is to expand and strengthen a Core center within the Cardiovascular and Metabolic Disease Signature Research Program (CVMD) at the University of New Mexico Health Sciences Center (UNMHSC). The Core is the Vascular Biology Researc | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $1,455,686 | Grant | Trans-NIH Recovery Act Research Support: Molecular and Cellular Mechanisms Underlying Function and Dysfunction of Neural Circuits. The overall purpose of this award is to recruit two junior faculty members (principal investigators) to a new Program in Neural Circuits and Behavior. Funds will sup | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $3,600,000 | Grant | Trans-NIH Recovery Act Research Support: This program addresses the synergistic interactions of combustion-generated organic pollutants and particles that increase their chemical and biological activity. Program goals include: 1) understand the relationships between the origin, mechanisms of for | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $5,963,606 | Grant | Trans-NIH Recovery Act Research Support: An interdisciplinary program for systems genomics of complex behaviors-ARRA 1P50MH090338 For this award, we propose a highly ambitious yet realistically attainable goal: to align existing expertise at UNC-Chapel Hill into a CEGS called CISGen. The ov | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF ILLINOIS | $1,362,875 | Grant | Trans-NIH Recovery Act Research Support: The theoretical framework of this study maintains that the main paradigm guiding the sociological study of the impact of psychosocial stressors on distress and drinking outcomes has primarily operationalized micro-level social stressors. By contract, stud | Health and Human Services, Department of / National Institutes of Health | 5/22/2009 |
| UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON | $443,669 | Grant | Trans-NIH Recovery Act Research Support: Award Description* DESCRIPTION (provided by applicant): Zinc is now believed to be an intracellular second messenger. It is hepatoprotective against various toxins and counteracts the oxidative stress elicited by compounds that have been linked to liver d | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $822,199 | Grant | Trans-NIH Recovery Act Research Support: Protein secretion is among the most important functions of hepatocytes. Defects in the secretory pathway can have serious consequences~ For instance, patients with congenital disorders of glycosylation in which secreted proteins are not properly glycosyla | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| UNIVERSITY OF IOWA, THE | $611,004 | Grant | Trans-NIH Recovery Act Research Support: Chronic alcoholism increases the incidence and severity of respiratory diseases and infections. Indeed, alcoholics compared to non-alcoholic individuals have increased mortality and morbidity during bacterialpneumonias. While much is known about the role | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| UNIVERSITY OF PITTSBURGH THE | $757,500 | Grant | Trans-NIH Recovery Act Research Support: Specific Aim: Examine cellular energetics and maintenance of the mitochondrial membrane potential (MMP) in ATP61 mutants. A. Examine energetics as a function of age in ATP61 mutants and controls. Young ATP61 mutants did NOT exhibit an energetic defect | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| NEW YORK UNIVERSITY (INC) | $760,688 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to develop a passive immunization approach to prevent humans accidentally exposed to prions from developing a universally fatal disease. Prion diseases (prionoses) are transmissible, invariably fatal, neurodegenerative diseases | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $994,267 | Grant | Trans-NIH Recovery Act Research Support: The present proposal seeks to determine the individual and interactive effects of estrogen and serotonin on cognitive processing and brain activation through the addition of functional magnetic resonance imaging (fMRI) to the paradigm of tryptophan deplet | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $685,774 | Grant | Trans-NIH Recovery Act Research Support: The project will develop a standardized Impairment Activity Staging System which specifies the medical impairment perceived by an individual or close proxy to be limiting his or her ability to perform daily activities, and then stages patients by severity | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $843,887 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Alzheimer's disease (AD) has been linked to deposition of beta-amyloid (Ab) as amyloid plaques in the brain. Transgenic mice expressing the human Ab precursor protein (APP) produce high levels of Ab and develop amyloid | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $970,039 | Grant | Trans-NIH Recovery Act Research Support: The objective of this study is to examine a model of health literacy coaching wherein Meals on Wheels (MOW) volunteers work with older adults to enhance patient communication skills. While considerable progress marks the studying of written health litera | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| UNIVERSITY OF CHICAGO, THE | $889,990 | Grant | Trans-NIH Recovery Act Research Support: High blood pressure is a strong, modifiable, independent risk factor for cardiovascular and renal disease, and was a primary or contributing cause of 11% of U.S. deaths in 2003 (American Heart Association, 2006). The health burden of high blood pressure | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| TUFTS MEDICAL CENTER, INC. | $632,829 | Grant | Trans-NIH Recovery Act Research Support: The tick-borne infections, Lyme disease, Ehrlichiosis and Babesiosis, are significant public health problem in the U.S. Once potential approach to the control of these diseases is to reduce carriage of the organisms in their wild-life reservoirs. In thi | Health and Human Services, Department of / National Institutes of Health | 5/27/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $732,083 | Grant | Trans-NIH Recovery Act Research Support: Our data indicates that the Dectin-1 beta-glucan receptor is essential for defense against Aspergillus fumigatus, the etiological agent of invasive pulmonary aspergillosis (IPA). We will uncover innate anti-fungal mechanisms mediated by Dectin-1 expressin | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| WASHINGTON UNIVERSITY, THE | $760,000 | Grant | Trans-NIH Recovery Act Research Support: This proposal is in response to Notice Number NOT-OD-09-088 of the American Recovery and Reinvestment Act of 2009. We request funding for the first two years of the revised grant application 1R01AI73718-01A2, with changes in scope approved by the NIAID P | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $770,000 | Grant | Trans-NIH Recovery Act Research Support: Aspergillus fumigatus and other species are increasingly the cause of morbidity and mortality among immunocompromised patients. Infections caused by these fungi are most prevalent in neutropenic patients with hematological malignancies. In the past few ye | Health and Human Services, Department of / National Institutes of Health | 5/06/2009 |
| BAYLOR COLLEGE OF MEDICINE | $1,011,610 | Grant | Trans-NIH Recovery Act Research Support: Herpesviruses are major pathogens in human populations, causing disease in normal and immuno-compromised individuals. Double-stranded DNA (dsDNA) tailed bacterial viruses and herpesviruses share surprising similarities in capsid assembly and organization. | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $754,984 | Grant | Trans-NIH Recovery Act Research Support: Bacterial flagellins are unusual microbial products that can be directly recognized by receptors of both the innate and adaptive immune system. Since flagellins initiate an innate immune response, they have the potential to function as molecularly defined | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $905,705 | Grant | Trans-NIH Recovery Act Research Support: Ebolaviruses and the closely related Marburgviruses continue to pose a lethal threat to human populations worldwide, especially given their potential use as bioweapons and the lack of effective vaccines or antiviral drugs to combat their pathogenicity and | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| WILLIAM MARSH RICE UNIVERSITY | $766,481 | Grant | Trans-NIH Recovery Act Research Support: Influenza A virus causes annual epidemics and is potential threat for widespread pandemics. The genome of influenza A virus consists of eight segments of (-)RNA that are encapsidated in distinct double-helical structures called the ribonucleoprotein (RNP) | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF FLORIDA | $732,500 | Grant | Trans-NIH Recovery Act Research Support: Acute lung infection due to Pseudomonas aeruginosa is a common cause of death in hospitalized patients and the major cause of death in Cystic Fibrosis. A number of virulence factors have been proposed to lead to these poor outcomes. We wish to re-examine | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| ST. JUDE CHILDREN'S RESEARCH HOSPITAL | $831,350 | Grant | Trans-NIH Recovery Act Research Support: Despite decades of work, the development of a successful HIV-1 vaccine has not yet been achieved. A better understanding of the requirements for HIV-1-specific lymphocyte activation, and the functions of activated lymphocytes, is therefore desired. The lo | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| DUKE UNIVERSITY | $750,486 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this project is to understand the fundamental aspects of outer membrane vesicles produced by Gram-negative bacteria: How and why are they made? Outer membrane vesicles represent 0.1 to 1% of total outer membrane protein in a growing | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE | $745,000 | Grant | Trans-NIH Recovery Act Research Support: CD4+ helper T cells specific for human immunodeficiency virus type 1 (HIV-1) are associated with control of viremia. Nevertheless, vaccines have not been effective thus far, at least partly because sequence variability and other structural features of the | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $949,500 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this research is to define the structural basis for substrate and inhibitor specificities of lentivirus PRs through comparative studies of FIV and HIV PRs. ARRA funding has allowed the continuation of these studies to prepare and test chime | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF WASHINGTON | $776,100 | Grant | Trans-NIH Recovery Act Research Support: Productive differentiation of thymic epithelium is critical for thymopoiesis and the establishment of self-tolerance. However, the differentiation program that forms the thymic environment is not well understood. Studies proposed here are intended to test | Health and Human Services, Department of / National Institutes of Health | 7/23/2009 |
| VIRGINIA COMMONWEALTH UNIVERSITY | $673,990 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of the proposed study is to determine how TonB-dependent and TonB-independent transport processes contribute to the ability of N. gonorrhoeae to grow in vitro and within clutured host cells. The specific aims of this proposal address the | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| WASHINGTON UNIVERSITY, THE | $758,216 | Grant | Trans-NIH Recovery Act Research Support: Project is currently on NCE through 8/31/12. arious members of the Ras superfamily of small GTPases, which comprise over 200 proteins, are expressed selectively in all cells, where they perform a range of cellular functions. A well-studied subfamily is th | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $1,056,296 | Grant | Trans-NIH Recovery Act Research Support: Bone is a complex system whose critical function is to be sufficiently stiff and strong to support the physical forces associated with daily activities. Understanding how genetic and environmental variants compromise this function is critical to fully und | Health and Human Services, Department of / National Institutes of Health | 8/07/2009 |
| WAKE FOREST UNIVERSITY | $740,000 | Grant | Trans-NIH Recovery Act Research Support: Loss of functional skeletal muscle due to congenital and acquired conditions, such as traumatic injury, tumor excision, etc., produces a physiological deficit for which there is still no effective clinical treatment. Tissue engineering of skeletal muscle | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| MAYO CLINIC | $1,230,557 | Grant | Trans-NIH Recovery Act Research Support: In 2008, over 66,000 people in the US will be diagnosed with Non-Hodgkin lymphoma (NHL), and over 19,000 will die of this cancer. Survival rates have only recently begun to improve, and the current 5-year survival rate is 66%. We have identified a number | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| CEDARS-SINAI MEDICAL CENTER | $575,814 | Grant | Trans-NIH Recovery Act Research Support: Hypothesis is that a unique recombinant fusion protein derived from a cell-penetrating viral capsid shell can transport DNA intercalating drugs through a tiny nucleic acid carrier, and target such drugs to specific tumor cells causing tumor-specific deliv | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| UNIVERSITY OF MARYLAND | $622,500 | Grant | Trans-NIH Recovery Act Research Support: Solid tumors are complex tissues containing both neoplastic tumor cells and non-neoplastic cell types (e.g., vascular endothelial cells (EC), fibroblasts and macrophages) and the interactions between these cells can regulate tumor progression. For example | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| UNIVERSITY OF TOLEDO, THE | $575,019 | Grant | Trans-NIH Recovery Act Research Support: Goals: Our initial goal is to define the molecular pathways that regulate RKIP expression in prostate cancer. The long-term goal of this research is to better define the role of RKIP as a prostate cancer metastasis suppressor in vivo, and to identify mole | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF WASHINGTON | $807,494 | Grant | Trans-NIH Recovery Act Research Support: Genital infection with oncogenic types of human papillomavirus (HPV) is central to the development of invasive cervical cancer (ICC) and its immediate precursor, cervical intraepithelial neoplasia grades II-III (CIN2-3). However, infection with these type | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $641,176 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The importance of the bone marrow in hematopoiesis has been well documented. However, the function of bone marrow in tumor T cell immunity is not well understood. Regulatory T cells (Tregs), dendritic cells (DCs) and e | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $1,260,932 | Grant | Trans-NIH Recovery Act Research Support: Our research amis at using chemical synthesis to prepare four classes of anticancer natural products with great potential that have eluded study due to their scarcity in nature and the fact that no solution for their chemical synthesis exists. Practical | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| WAKE FOREST UNIVERSITY | $819,892 | Grant | Trans-NIH Recovery Act Research Support: Interaction of germline and somatic changes in PCa progression Abstract Recent successes in discovering germline variants associated with prostate cancer (PCa) risk is encouraging. However, whether these risk variants play role in PCa progression is uncle | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $1,354,140 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to develop a software tool kit (based on the XIP application from Siemens corporation) that will allow scientists to study prostate cancer by combining data from multiple imaging modalities (radiology and pathology) with molec | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $660,472 | Grant | Trans-NIH Recovery Act Research Support: Meta!astatic melanoma is a deadly cancer, lacking an effective therapeutic strategy. It is widely acce:ted that dysfunctions of normal homeostatic regulation of melanoblasts result in neoplastic convirsion to melanomas, while the exact molecular mechanism | Health and Human Services, Department of / National Institutes of Health | 6/25/2009 |
| NEW ENGLAND RESEARCH INSTITUTES, INC. | $383,808 | Grant | Trans-NIH Recovery Act Research Support: Prescription drug sales have increased nearly 90% between 2000 and 2006, with further increases likely given the January 1, 2006 implementation of prescription drug benefits for seniors. Urologic symptoms are also on the increase; the projected burden of | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| NORTHWESTERN UNIVERSITY | $419,375 | Grant | Trans-NIH Recovery Act Research Support: The metabolically obese normal weight (MONW) phenotype is a clustering of obesity-related metabolic disorders in persons with normal body mass index (BMI). Type 2 diabetes (T2DM) in normal weight persons is an intriguing representation of the MONW phenoty | Health and Human Services, Department of / National Institutes of Health | 7/23/2009 |
| UNIVERSITY OF IOWA, THE | $410,700 | Grant | Trans-NIH Recovery Act Research Support: Human coronaviruses (HCoVs) are positive-stranded RNA viruses that are estimated to account for approximately 30% of cases of the common cold. The emergence of a novel HCoV as the etiologic agent of severe acute respiratory syndrome (SARS) demonstrated th | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $432,405 | Grant | Trans-NIH Recovery Act Research Support: This study will define mucosal virulence and mechanism of innate immune host defense against aerosolized Rift Valley fever virus, a Category A biodefense pathogen. Rift Valley Fever virus (RVFV) is designated a priority pathogen based upon its projected s | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $427,657 | Grant | Trans-NIH Recovery Act Research Support: Giardia lamblia is a common cause of intestinal infections. We propose to screen large collections of small molecules to identify new leads for future development of drugs against this parasite. | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| MAYO CLINIC | $299,176 | Grant | Trans-NIH Recovery Act Research Support: Recently, there has been an increased interest in 'individualized medicine' and thus pharmacogenetics and pharmacogenomics in cancer research have moved to the forefront as well. Pharmacogenetics is the study of the role of inheritance in individual varia | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF WASHINGTON | $377,410 | Grant | Trans-NIH Recovery Act Research Support: The chance of developing invasive breast cancer during a woman's lifetime is approximately 1 in 8 and more that 40,000 women die of metastatic disease each year. Inherent or acquired tumor drug resistance and dose-limiting toxicity limit many agents used | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF ARIZONA | $357,129 | Grant | Trans-NIH Recovery Act Research Support: Protein kinases are widely implicated in human disease, especially in cancer, and play a fundamental role in human biology. In order to understand the so-called 'phospho-proteome' one needs new tools to address which particular kinase(s) are active (usual | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF PITTSBURGH THE | $366,630 | Grant | Trans-NIH Recovery Act Research Support: Prostate cancer, a leading cause of cancer related deaths among men in the United States, is usually diagnosed in the sixth or seventh decades of life, which allows a large window of opportunity for intervention to prevent or slow progression of the disea | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $594,612 | Grant | Trans-NIH Recovery Act Research Support: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths. Although many cases of HCC are induced by chronic alcohol abuse or environmental toxins, approximately 80% are caused by infection with either hepatitis B or hepatitis C virus (HC | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF NEW MEXICO | $1,459,602 | Grant | Trans-NIH Recovery Act Research Support: The spread of HIV and sexually transmitted diseases (STD) remains one of the most serious threats to general adolescent health. The severity of the STD/HIV threat increases significantly for adolescents when the intercorrelated use of illicit drugs and a | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF MARYLAND | $744,180 | Grant | Trans-NIH Recovery Act Research Support: More than 850,000 Americans are currently living with AIDS and an estimated 40,000 continue to contract HIV each year (CDC, 2004). Minority individuals living in urban and poverty-stricken areas who engage in injection heroin use are particularly at risk | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| UNIVERSITY OF WASHINGTON | $2,703,717 | Grant | Trans-NIH Recovery Act Research Support: The revised scope of work focuses on the SSDP longitudinal study, and NYS is not included. The revision permits the accomplishment of the first three aims of the originally proposed five year study. In addition, this support will place the study in an opt | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $592,000 | Grant | Trans-NIH Recovery Act Research Support: Neural Mechanisms of Heroin-induced Conditioned Immunomodulation Our laboratory was the first to demonstrate that the detrimental health consequences of opiates can be conditioned to environmental stimuli predictive of drug administration. The proposed st | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF FLORIDA | $926,607 | Grant | Trans-NIH Recovery Act Research Support: The primary purpose of this research is to develop and evaluate the short-term efficacy of an innovative multiple behavior screening, brief intervention and referral to treatment (MB-SBIRT) model using social and self-image to simultaneously link and redu | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | $627,250 | Grant | Trans-NIH Recovery Act Research Support: A scientific search for therapeutically useful compounds in combating psychostimulant abuse and addiction has been in progress for decades, with no clinically available agents to date. Rational, brain receptor protein-guided design of novel antidepressant | Health and Human Services, Department of / National Institutes of Health | 6/17/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $721,626 | Grant | Trans-NIH Recovery Act Research Support: Marijuana is the most commonly used illicit substance among adolescents in the United States. Marijuana has profound effects on cognition, memory, and psychomotor skills. Optimal performance in these domains is critical for adolescents to achieve the ne | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $1,077,998 | Grant | Trans-NIH Recovery Act Research Support: Cannabis use disorder (CUD) occurs frequently in patients with schizophrenia (SCZ) and worsens the course of this severe psychiatric disorder. Treatments available for these 'dual diagnosis' patients are inadequate. Most of the antipsychotic drugs appear | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $822,680 | Grant | Trans-NIH Recovery Act Research Support: An understanding of the morphogenesis and operation of hair cells requires identification of the genes expressed in these cells and of the functions of the cognate proteins. As an initial step towards this goal, we have used DNA-microarray technology to i | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| SEATTLE BIOMEDICAL RESEARCH INSTITUTE | $867,600 | Grant | Trans-NIH Recovery Act Research Support: This proposal is analyzing the interactions between azole antifungal drugs and fungal cells by studying both the growth parameters (biochemical and microbiological), and the gene expression patterns of susceptible and resistant isolates. The results have | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO | $593,833 | Grant | Trans-NIH Recovery Act Research Support: The management of inflammatory pain represents a major scientific and health care challenge and many currently used analgesics provide inadequate pain relief. A mechanistic-based approach to pain management might contribute to the development of valid and | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY OF KENTUCKY | $800,922 | Grant | Trans-NIH Recovery Act Research Support: An association between infection and suboptimal regenerative outcomes has often been described in the periodontal and oral surgical literature. It is also increasingly recognized that low-level bacterial contamination can play a role in 'aseptic' loosenin | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF MIAMI | $738,500 | Grant | Trans-NIH Recovery Act Research Support: Characterization of TGR5-D2-WSB1 pathway - testing the hypothesis that TGR5 and WSB1 regulation of D2 activity and thyroid hormone activation is a key pathway involved in the control of energy homeostasis. Generating genetically engineered mouse models (G | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE | $669,514 | Grant | Trans-NIH Recovery Act Research Support: Mounting evidence indicates that alterations in chromatin structure and function induce specific and significant changes in gene expression. Histone deacetylases (HDACs) are an evolutionarily conserved class of enzymes which remove acetyl groups from hist | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| ST. JUDE CHILDREN'S RESEARCH HOSPITAL | $540,036 | Grant | Trans-NIH Recovery Act Research Support: While our knowledge on early liver development increased considerably in the past decade, much remains to be learned on how the distinct regulators of liver organogenesis operate at the molecular level. This information is necessary not only to uncover ho | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $811,834 | Grant | Trans-NIH Recovery Act Research Support: With the increase in obesity and diabetes, other chronic diseases are also increasing. Nonalcoholic fatty liver disease (NAFLD) is one such disease that has potentially enormous public health consequences. NAFLD is a leading cause of chronic liver disease | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $828,197 | Grant | Trans-NIH Recovery Act Research Support: Given that only organs in pristine condition are transplantable, orthotopic transplantation will always remain a limited pool. A more elegant, long-term solution is using stem cells to develop tissue-engineered replacements. However, while many in vitro s | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| PURDUE UNIVERSITY | $650,100 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION: Chronic non-bacterial inflammation of the prostate is associated with multiple prostate diseases including chronic prostatitis-chronic pelvic pain syndrome (CP-CPPS), benign prostatic hyperplasia (BPH), and prostate cancer. CP-CPPS is disease | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $884,791 | Grant | Trans-NIH Recovery Act Research Support: We hypothesize that a profound deficiency of nutritional vitamin D (25-hydroxyvitamin D; 25D) in end-stage renal disease (ESRD) leads to an altered immune response, predisposing to early morbidity and mortality from infection, the second-leading cause of | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF UTAH, THE | $601,667 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Particulate air pollutants (particulate matter; PM) are ubiquitous in the environment. Increases in human respiratory and cardiovascular dysfunction, disease, and mortality have been linked to both short- and long- ter | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| NORTH CAROLINA STATE UNIVERSITY | $658,367 | Grant | Trans-NIH Recovery Act Research Support: There has been explosive growth in engineering disciplines based on nanomaterials. Their unique physical properties compared to larger microparticles both enable these novel engineering applications as well as raise questions related to their interaction | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF CALIFORNIA, SANTA BARBARA | $602,322 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The proposed research investigates a representation of spatial layout that serves to guide action in the absence of direct perceptual support. We call this representation a 'spatial image.' Humans can perceive surround | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $731,340 | Grant | Trans-NIH Recovery Act Research Support: New approaches to lower intraocular pressure, a significant risk factor for the progression of glaucoma, will be investigated. Gene therapy approaches will be utilized to lower IOP by enhancing outflow via the uveoscleral pathway. One of the current most | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| OAKLAND UNIVERSITY | $709,009 | Grant | Trans-NIH Recovery Act Research Support: This award addresses critically important unresolved issues concerning the antioxidant capacities of vertebrate photoreceptor cells and inner retinal neurons. A common factor in the loss of photoreceptor cells appears to be reactive oxygen species generat | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| UNIVERSITY OF OKLAHOMA | $732,500 | Grant | Trans-NIH Recovery Act Research Support: Choroidal neovascularization (CNV) is a severe complication of age-related macular degeneration (AMD). Human genetic studies have recently revealed significant association of the very low-density lipoprotein receptor (VLDLR) and a wnt co-receptor, low-den | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY OF OKLAHOMA | $738,065 | Grant | Trans-NIH Recovery Act Research Support: There are now almost 200 genes and chromosomal loci which have been identified as causing some form of inherited retinal degeneration. Irrespective of the primary mutation or cause, all of these diseases are thought to share a major common event. This is | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $902,153 | Grant | Trans-NIH Recovery Act Research Support: Despite the major public health impact, the etiologies of refractive errors generally and myopia in particular are poorly understood. We are conducting an innovative approach to evaluate altered gene expression in eyes of chicks developing refractive erro | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| DUKE UNIVERSITY | $702,000 | Grant | Trans-NIH Recovery Act Research Support: Note: This project is being supported with funds from the American Recovery and Reinvestment Act, which resulted in a reduction in the research aims and scope. A revised abstract has been provided. Age-related macular degeneration (AMD) is a late-onset, | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $737,500 | Grant | Trans-NIH Recovery Act Research Support: The broad objective of this project is to prevent degeneration of cone photoreceptors, which are essential for human color vision. In a disease such as Leber Congenital Amaurosis (LCA), the levels of the native chromophore of visual pigments, the Vitamin | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $1,621,296 | Grant | Trans-NIH Recovery Act Research Support: DiffeProper transgene expression is essential to achieve therapeutic effect and ensure safety in many gene therapy strategies. Current regulation systems for controlling transgene expression typically require use of a special promoter and co-delivery of a | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| WRIGHT STATE UNIVERSITY | $591,948 | Grant | Trans-NIH Recovery Act Research Support: The project will study the DNA unwinding element binding protein DUE-B, with the goal of determining the mechanism by which the binding of DUE-B to replication origins is controlled, and by which DUE-B regulates the binding of other replication initiation | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| NORTH CAROLINA STATE UNIVERSITY | $530,052 | Grant | Trans-NIH Recovery Act Research Support: Extreme thermoacidophily (growth -?+? 60-?+?C, pH -?+? 3) is a remarkable growth physiology exhibited by certain members of the Crenarchaeota and Euryarchaeota, the major archaeal phyla. Interesting features of microorganisms in this group include: exploi | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| RENSSELAER POLYTECHNIC INSTITUTE | $596,994 | Grant | Trans-NIH Recovery Act Research Support: The Golgi is the organelle responsible for the posttranslational modification of proteins. Glycosylation, the most prominent posttranslational modification, results in the biosynthesis of glycoproteins and proteoglycans (PGs). Glycosylation is not templat | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $647,563 | Grant | Trans-NIH Recovery Act Research Support: For the hundreds of thousands whose lives have been saved by antiretroviral therapy (ART), scale-up has been a success. There is an urgent need, however, to better understand how access to ART shapes risk and protective behaviors. Moreover, growing concer | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF FLORIDA | $45,150 | Grant | Trans-NIH Recovery Act Research Support: Maternal cortisol concentrations are normally increased by 2-3 fold in pregnancy. Maternal cortisol levels appear to affect fetal skeletal and visceral growth. Our previous data show reduced growth in fetuses of ewes with either increased or decreased mat | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $737,352 | Grant | Trans-NIH Recovery Act Research Support: SWI/SNF & Yolk Sac Development The mammalian yolk sac and placenta provide an important nutritive role in the early postimplantation embryo. Development of these tissues is highly sensitive to the regulation of temporal and spatial expression of a number | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| CORNELL UNIVERSITY, INC | $761,954 | Grant | Trans-NIH Recovery Act Research Support: Sexual reproduction provides ample opportunity for pairwise interactions between the genotypes of mating pairs. One consequence of processes that are rife with male x female interactions is that evolution may fail to optimize functions for either sex, and | Health and Human Services, Department of / National Institutes of Health | 8/24/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $749,480 | Grant | Trans-NIH Recovery Act Research Support: Cerebral hypoxia-ischemia during the perinatal period is the single most important cause of acute newborn mortality and chronic disability. Despite our increasing understanding of the mechanisms of neuronal injury, an effective clinical therapy has yet to | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| MEDICAL COLLEGE OF WISCONSIN, INC., THE | $1,463,089 | Grant | Trans-NIH Recovery Act Research Support: The long-term aim of this research is to understand how human genetic variation influences drug toxicity. In this ARRA request, we will continue our efforts to elucidate mechanisms underlying adverse drug reactions to oral anticoagulants, specifically th | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| WASHINGTON UNIVERSITY, THE | $780,579 | Grant | Trans-NIH Recovery Act Research Support: Mucopolysaccharidosis I (MPS I) and MPS VII are lysosomal storage diseases in which glycosaminoglycans (GAG) accumulate due to deficient activity in alpha-L-iduronidase and beta-glucuronidase, respectively. This results in multisystemic disease involving | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| NEW YORK UNIVERSITY (INC) | $2,262,855 | Grant | Trans-NIH Recovery Act Research Support: The most significant determinant of educational and clinical impairment in school-age children with autism spectrum disorders (ASD) is the frequent co-occurrence of hyperactivity and inattention symptoms. In response, clinicians treating ASD are increasin | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| NORTHWESTERN UNIVERSITY | $216,994 | Grant | Trans-NIH Recovery Act Research Support: The expected broad impact of the proposed activity are: (A) the theoretical models being developed would provide much needed guidance in the experimental efforts to develop a viable ultra rapid DNA sequencing technology based on the nanapore idea. The ab | Health and Human Services, Department of / National Institutes of Health | 8/12/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $823,054 | Grant | Trans-NIH Recovery Act Research Support: In this proposal, we describe a new pathway signaling PMN influx and damage to the airways that may play a role as an initiator or cofactor for chronic obstructive pulmonary disease (COPD). Specifically, chemical or enzymatic breakdown of collagen releas | Health and Human Services, Department of / National Institutes of Health | 8/07/2009 |
| UNIVERSITY OF PITTSBURGH THE | $1,538,421 | Grant | Trans-NIH Recovery Act Research Support: Racial disparities exist in cardiovascular disease (CVD), with blacks having more prevalent and severe CVD compared to whites, independent of race-related differences in CVD risk factors. Despite having higher rates of CVD, blacks are less likely than whi | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $991,426 | Grant | Trans-NIH Recovery Act Research Support: The lung is constantly under a pre-existing tensile stress or prestress generated by transpulmonary pressure which changes cyclically with breathing. This prestress is transmitted through the alveolar walls to the extracellular matrix (ECM) in the form of | Health and Human Services, Department of / National Institutes of Health | 5/30/2009 |
| UNIVERSITY OF UTAH, THE | $1,056,378 | Grant | Trans-NIH Recovery Act Research Support: Sepsis, a maladaptive response to infection, is a common and lethal syndrome. Many studies have examined the activities of leukocytes and endothelial cells in sepsis or in surrogate models, but the role of platelets in the disease process has received far | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| TEXAS A&M UNIVERSITY SYSTEM,THE | $792,977 | Grant | Trans-NIH Recovery Act Research Support: Diabetes mellitus (DM) is of major epidemiological importance, accounting for a high incidence of heart failure in these patients. Hyperglycemia, as an independent risk factor, directly causes cardiac damage and leads to diabetic cardiomyopathy. Apart fro | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF KENTUCKY | $833,673 | Grant | Trans-NIH Recovery Act Research Support: Telomeres, the DNA TTAGGG repeat sequences at the ends of eukaryotic chromosomes, are stabilized by telomerase to serve as protective capping and to prevent degradation. Stem cells constitutively overexpress the catalytic core telomerase reverse transcrip | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| NORTHWESTERN UNIVERSITY | $1,298,274 | Grant | Trans-NIH Recovery Act Research Support: Short sleep duration (less than 6 hours/night) is associated with a higher prevalence and incidence of hypertension, diabetes, and overweight/obesity, all of which can contribute to coronary heart disease. Pathophysiologic mechanisms that could explain th | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF PITTSBURGH THE | $1,452,921 | Grant | Trans-NIH Recovery Act Research Support: Primary lymphedema is the clinical expression of defects in lymphatic development and function. Three genes have been shown to cause primary lymphedema, VEGFR3, FOXC2 and SOX18. Mutations in these genes account for only a fraction (~1/3) of all cases of p | Health and Human Services, Department of / National Institutes of Health | 9/10/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON | $1,550,402 | Grant | Trans-NIH Recovery Act Research Support: According to the World Health Organization, 15 million people worldwide suffer a stroke every year. Of these, 5 million die and another 5 million are left permanently disabled, placing a heavy burden on families, communities, and governments. While patien | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF ARIZONA | $743,821 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this project is to increase understanding of the transcriptional regulation of vascular endothelial gene expression, especially during development of the embryonic vascular system. Ets family transcription factors have been strongly im | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $810,015 | Grant | Trans-NIH Recovery Act Research Support: Cyclic AMP is a highly versatile second messenger in the heart, transducing an array of different receptor stimuli into coordinated regulation of cardiac functions including excitation-contraction (EC) coupling and gene transcription. But how cAMP can sel | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | $1,728,158 | Grant | Trans-NIH Recovery Act Research Support: Carcinoembryonic antigen related cell adhesion molecule 1 (CEACAM-1) is atransmembrane protein found on leukocytes, endothelium, and epithelium. Its activation canattenuate colitis in murine models. Microarray analysis revealed that CEACAM-1 is increased | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $424,740 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The Role of Zinc Finger Genes in Leukemogenesis: The objective of the proposed study is to understand normal hematopoiesis and the malignant transformation of hematopoietic cells by identifying the biological functions | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| NEW YORK UNIVERSITY (INC) | $1,175,984 | Grant | Trans-NIH Recovery Act Research Support: Obesity is one of the most pressing public health problems in the United States. Through its negative influence on cardiovascular disease, diabetes, and cancer, obesity is a significant contributor to premature morbidity and mortality, as well as economic | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF ILLINOIS | $1,053,536 | Grant | Trans-NIH Recovery Act Research Support: Poor diet and obesity have been linked to increased risks for a number of chronic diseases including cancer and cardiovascular diseases. The proposed research will investigate the relationship between food (candy, baked goods, and chips), beverage (soda) | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF KENTUCKY | $702,543 | Grant | Trans-NIH Recovery Act Research Support: Airway hypersensitivity, characterized by exaggerated sensory and reflexogenic responses to inhaled irritants, is a prominent pathophysiological feature of various airway inflammatory diseases (e.g., asthma, bronchitis, etc). Increasing and compelling evi | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF HOUSTON SYSTEM | $1,125,000 | Grant | Trans-NIH Recovery Act Research Support: Global multiple sequence alignment is the most basic step in the comparative study of molecular sequences. It is also the foundation of numerous subsequent biological analyses, such as phylogenetic reconstruction, gene annotation, and three-dimensional st | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| UNIVERSITY OF CHICAGO, THE | $1,211,040 | Grant | Trans-NIH Recovery Act Research Support: Our hypothesis is that we can drastically accelerate scientific discovery by collecting and making visible, comparable, and computable hypotheses, hunches, and theory-specific evidence beyond the dominant paradigm(s) of the field. Accordingly, we propose | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| THE VANDERBILT UNIVERSITY | $1,220,082 | Grant | Trans-NIH Recovery Act Research Support: Ultimately, we want to know what factors are important to provide superior prevention, diagnosis, and treatment of human disease. Unfortunately, interpretation of statistical models in a meaningful way for biomedical research has been lacking due to the | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $1,657,238 | Grant | Trans-NIH Recovery Act Research Support: Maternal depressive symptoms are associated with reduced maternal quality of life, decreased ability to function, increased infant hospitalizations, reduced breastfeeding, less involvement of mothers with important developmental behaviors such as talking | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| GROUP HEALTH COOPERATIVE | $996,677 | Grant | Trans-NIH Recovery Act Research Support: While many effective depression treatments (medications and psychotherapies) are available, individuals vary widely in response to specific treatments. Unfortunately, our ability to match any individual to the most effective treatment is hardly better tha | Health and Human Services, Department of / National Institutes of Health | 5/13/2009 |
| HENRY FORD HEALTH SYSTEM | $732,500 | Grant | Trans-NIH Recovery Act Research Support: This proposal aims to test if the size of the MT- and/or MRCA-MRI parameter changes at an early stage of stroke can be used to establish a threshold of BBB damage that portends subsequent HT and if changes of this magnitude or larger can be used to identi | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $292,617 | Grant | Trans-NIH Recovery Act Research Support: The dual outbreaks of HIV infection and early (primary and secondary) syphilis among 15-30 year old African-American men who have sex with men (MSM) in North Carolina (NC) may be driven by men who are co-infected. Biologically, HIV and syphilis transmissi | Health and Human Services, Department of / National Institutes of Health | 5/04/2009 |
| TEXAS TECH UNIVERSITY SYSTEM | $383,786 | Grant | Trans-NIH Recovery Act Research Support: Project Plan: This project will explore novel strategies to accelerate the progress of searching for novel analgesic and anti-inflammatory agents. It is known that research on analgesic and anti-inflammatory agents has been among the most active topics in | Health and Human Services, Department of / National Institutes of Health | 5/18/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $169,000 | Grant | Trans-NIH Recovery Act Research Support: Chronic exposure to opioids can lead to dependence, a phenomenon that is manifest by withdrawal-induced somatic, autonomic, and aversive symptoms that critically involve the central nucleus of the amygdala (CeA). Avoiding physical withdrawal symptoms can | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| DUKE UNIVERSITY | $468,000 | Grant | Trans-NIH Recovery Act Research Support: This application is in response to RFA DA-09-016, 'Behavioral Pharmacology and Genetics, Translating and Targeting Individual Differences.' The proposed project will examine the genetic basis of individual differences in inhibitory control (IC) and how th | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF CINCINNATI | $471,000 | Grant | Trans-NIH Recovery Act Research Support: Ecstasy (primarily containing MDMA) use continues to be major public health problem, especially among young adults. Animal studies suggest that ecstasy is a selective serotonin neurotoxin. However, the effects of ecstasy use on the human brain continue to | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $295,602 | Grant | Trans-NIH Recovery Act Research Support: Infant incubators are widely used in neonatal intensive care units (NICU) for the care of pre-term babies, as they cannot cope with the environment without external help. However, excessive high levels of noise inside an infant incubator have been found t | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER | $136,960 | Grant | Trans-NIH Recovery Act Research Support: Intrauterine growth restriction (IUGR) alters lung development, increasing the risk of respiratory compromise throughout postnatal life. Vertical integration of the cell-molecular mechanism(s) underlying this respiratory compromise offers a powerful funct | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| COLORADO SEMINARY | $151,500 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this project is to investigate the relative contribution of familiarity and recollection to the development of visual recognition memory in infants. Recollection involves the retrieval of information about the context in which an item was | Health and Human Services, Department of / National Institutes of Health | 9/10/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $154,500 | Grant | Trans-NIH Recovery Act Research Support: The pituitary gland is an endocrine organ that secretes hormones to control various vital processes throughout the body, including growth during childhood, the stress response, sexuality, reproduction, metabolic homeostasis, and lactation. It dynamically | Health and Human Services, Department of / National Institutes of Health | 4/29/2009 |
| UNIVERSITY OF ROCHESTER | $153,521 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this application is to explore the involvement of non-classical MHC class Ib (class Ib) molecules in thymocyte differentiation during early development by a comparative approach in the Xenopus. Increasing evidence suggests that in the | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| DUKE UNIVERSITY | $156,000 | Grant | Trans-NIH Recovery Act Research Support: The goal of this R03 proposal is to identify molecular mechanisms underlying the regulation of inhibitory synaptic transmission by the cell adhesion molecule (CAM) neuroligin 2 (NL2). Although it has been established that neuroligins mediate synaptogenic | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (INC) | $155,000 | Grant | Trans-NIH Recovery Act Research Support: ARRA - TRANS-NIH RECOVERY ACT RESEARCH SUPPORT. Behavioral Feedback and Neuronal Lifespan. To identify behavioral factors that impact neuron cell death in populations of neurons that are normally replaced throughout adulthood. | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| BRIGHAM YOUNG UNIVERSITY | $225,000 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this research is to identify the genetic basis underlying directional growth of cells in the embryonic limb (i.e., the limb mesenchyme). We have previously demonstrated that a structure found at the distal tip of the limb known as the apic | Health and Human Services, Department of / National Institutes of Health | 8/07/2009 |
| UNIVERSITY OF ALABAMA IN HUNTSVILLE | $220,750 | Grant | Trans-NIH Recovery Act Research Support: Cell survival, division, and differentiation are dependent on a delicate balance between the rates of protein synthesis and degradation. The Ubiquitin-Proteasome System (UPS) is one of the primary pathways for regulating protein turnover in the eukaryotic | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| J.DAVID GLADSTONE INSTITUTES, THE | $21,931 | Grant | Trans-NIH Recovery Act Research Support: TDP-43 is a major pathological protein in amyotrophic lateral sclerosis (ALS) and some forms of frontotemporal dementia (FTD) and is also present in ubiquitinated inclusions seen in other neurodegenerative diseases. How TDP-43 contributes to age-dependent | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF CONNECTICUT | $239,241 | Grant | Trans-NIH Recovery Act Research Support: The National Institute of Alcohol Abuse and Alcoholism has identified hazardous drinking in college students as a significant concern and a research priority due to its significant prevalence on many college campuses and its association with many adverse | Health and Human Services, Department of / National Institutes of Health | 5/13/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $464,700 | Grant | Trans-NIH Recovery Act Research Support: The research proposed here will use archival data and multi-level/hierarchal spatial modeling to examine the geography of alcohol outlets and violence, over time, in the city of Boston. We will determine whether and how place matters in regard to the rela | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| SYRACUSE UNIVERSITY | $398,948 | Grant | Trans-NIH Recovery Act Research Support: Scientific Rationale: The transition from adolescence to adulthood involves important developmental challenges. Events during this key developmental phase can profoundly shape and influence academic and occupational achievement as well as affect health ou | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $431,750 | Grant | Trans-NIH Recovery Act Research Support: We have recently developed potassium channel-mutant mice that are very sensitive to low concentrations of alcohol. Hence, these mice will serve as well-defined rodent models to study the electrophysiological changes, i.e., altered neuronal firing patterns | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| UNIVERSITY OF KENTUCKY | $334,866 | Grant | Trans-NIH Recovery Act Research Support: Premature cell senescence induced by oncogenes and oxidative stress in vitro recapitulates many facets of replicative senescence and in vivo cellular aging. With the recent findings of a tumor suppressor role for senescent cells in vivo, the establishment | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $336,200 | Grant | Trans-NIH Recovery Act Research Support: Title: Ancillary Studies to the AD Neuroimaging Initiative (R21). This award is for ancillary studies to the Alzheimer ?s Disease Neuroimaging Initiative (ADNI), a multi-site, longitudinal, prospective, naturalistic study of normal cognitive aging, mild c | Health and Human Services, Department of / National Institutes of Health | 5/18/2009 |
| DUKE UNIVERSITY | $255,840 | Grant | Trans-NIH Recovery Act Research Support: Our goal is to generate a mouse model that closely resembles Alzheimer's Disease. In our first attempt we have developed two mouse models of AD that progress from A production and amyloid deposition to hyperphosphorylated native mouse tau at AD-associated | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $415,000 | Grant | Trans-NIH Recovery Act Research Support: Progress toward the development of genetically modified mosquito (GMM) strains to be used in a genetic control program for mosquito vectors of malaria has reached a point where most of the scientific community involved in this research are beginning to th | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| OREGON STATE UNIVERSITY | $402,050 | Grant | Trans-NIH Recovery Act Research Support: All living cells establish transmembrane electrochemical gradients with the help of primary ion pumps. Primary Na pumps have been discovered in many microorganisms and a transmembrane circulation of Na ions may play a significant role in the physiology of | Health and Human Services, Department of / National Institutes of Health | 5/06/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $202,428 | Grant | Trans-NIH Recovery Act Research Support: Antigen processing is an integral part of cell-mediated immune surveillance and responses that involve MHC- restriction and T cell recognition. Processed antigenic peptides, when presented on cell surface by MHC molecules to T cells, serve as identity tag | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| UNIVERSITY OF MARYLAND | $412,500 | Grant | Trans-NIH Recovery Act Research Support: Hepatitis E virus (HEV) causes endemic and large epidemics of acute human hepatitis and sporadic cases by a fecal-oral transmission in many parts of the world. HEV generally infects young adults and the disease has a high mortality rate, up to 20%, in in | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| WAKE FOREST UNIVERSITY | $407,000 | Grant | Trans-NIH Recovery Act Research Support: We propose this R21 feasibility study to assess factors related to recruiting rural and minority parents to a study that would involve themselves and their children in an assessment of their behavioral, home environmental and genetic characteristics. Spe | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $397,800 | Grant | Trans-NIH Recovery Act Research Support: Bacillus anthracis and other bacterial pathogens are among the more pronounced threats in the arena of bio- terrorism and biological warfare, while the occurrence of resistant strains of other gram positive pathogens (including Staphylococcus aureus, and | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| LOYOLA UNIVERSITY | $411,125 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this two year R21 exploratory award is to characterize and confirm the role of inflammatory cells in wound healing and determine whether the subset of innate lymphocytes regulates the wound healing process via modulation of the local inflam | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| BAYLOR COLLEGE OF MEDICINE | $383,750 | Grant | Trans-NIH Recovery Act Research Support: 'Infections associated with indwelling medical devices, particularly catheters account for about half of nosocomial infections in the United States. These infections prolong hospital stay and result in substantial morbidity and mortality. Bacterial coloni | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $431,750 | Grant | Trans-NIH Recovery Act Research Support: Candida albicans (CA) is the most commonly isolated fungus associated with biofilms [extracellular matrix (ECM)-encased microbial communities formed on indwelling medical devices which are resistant against commonly used antifungals. The carbohydrate-rich | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF ILLINOIS | $431,750 | Grant | Trans-NIH Recovery Act Research Support: The awarded project aims to comprehensively identify and characterize genes involved in resistance to human endogenous antimicrobial peptides such as cationic defensin and anionic dermcidin, in Gram-negative bacteria E. coli and Salmonella enterica. Anti | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| UNIVERSITY OF UTAH, THE | $440,876 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): After budding from the cell, retroviruses (such as HIV) undergo a complex spontaneous process called maturation that is required for their infectivity. During maturation retroviruses undergo dramatic internal reorganiz | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $408,251 | Grant | Trans-NIH Recovery Act Research Support: The bacterium Bacillus anthracis causes anthrax in humans; as a bioterrorism agent the bacteria are a threat to public health. Our laboratory has recently reported a cell wall polysaccharide of a B. anthracis (termed HF-PS) with a structure specific to th | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) | $429,000 | Grant | Trans-NIH Recovery Act Research Support: Type I (IFN-?/?) and type III (IFN-?s) IFNs are important components of the host antiviral response. Although type III IFNs possess intrinsic antiviral activity similar to that of type I IFNs, they signal through specific unique receptor complexes and th | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF PITTSBURGH THE | $416,625 | Grant | Trans-NIH Recovery Act Research Support: These studies are focused on the molecular structures of protein complexes that form between the HIV virulence factor Nef and host cell signaling proteins (Src-family kinases) in HIV-infected cells. Formation of these complexes is important to AIDS progr | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF WISCONSIN- SYSTEM | $372,680 | Grant | Trans-NIH Recovery Act Research Support: Overview: Aspergillus fumigatus is an inhaled fungus that can infect human patients with immune suppression. At this time, most individuals that become infected by this organism do not survive, despite aggressive medical management. The long-term goal of | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| HEALTH RESEARCH, INC. | $545,001 | Grant | Trans-NIH Recovery Act Research Support: Asthma is a disease of chronic inflammation marked by periodic bouts of acute exacerbations of airway obstruction, and early sub-clinical eosinophilic pulmonary inflammation precedes the development of asthma in children. Why certain individuals develop | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $424,875 | Grant | Trans-NIH Recovery Act Research Support: Congenital infection with human cytomegalovirus (HCMV) occurs in approximately 40,000 infants a year in the United States annually and is the leading viral cause of birth defects. These problems together with the severe disease that HCMV causes in solid o | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| TEXAS A&M UNIVERSITY SYSTEM,THE | $402,875 | Grant | Trans-NIH Recovery Act Research Support: Tuberculosis, caused by Mycobacterium tuberculosis, continues to be a public health problem in many countries including the United States because of its prevalence in HIV-infected patients and also due to the emergence of multi-drug resistant (MDR) and ex | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| FRAUNHOFER USA, INC. | $347,304 | Grant | Trans-NIH Recovery Act Research Support: The emergence of bacterial resistance to antibiotics continues to be a significant public health challenge. Factors contributing to the rise in antibiotic resistance include widespread and inappropriate prescription of broad spectrum antibiotics and patie | Health and Human Services, Department of / National Institutes of Health | 7/23/2009 |
| LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY | $457,500 | Grant | Trans-NIH Recovery Act Research Support: Protein deubiquitination in lymphocyte signaling: The long-term goal of this laboratory is to understand the process of ubiquitin conjugation in the regulation of immune responses. Protein ubiquitination is carried out by a cascade of enzymatic reactions | Health and Human Services, Department of / National Institutes of Health | 5/22/2009 |
| STEVENS INSTITUTE OF TECHNOLOGY (INC) | $407,500 | Grant | Trans-NIH Recovery Act Research Support: Despite attractive, ionizing radiations cannot be directly applied in the treatment of bacterial infections since bacteria are extremely insensitive to radiations. The lethal radiation dose for bacteria is at least 1,000 times higher than the whole-body l | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $433,125 | Grant | Trans-NIH Recovery Act Research Support: Clearance of many viral infections is critically dependent on the function of CD8 T cells in the immune system. Recent results have shown that CD8 T cells become functionally defective when CD4 T cell help is absent. This loss of functionality in CD8 T c | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE | $453,750 | Grant | Trans-NIH Recovery Act Research Support: Studies of virus specific immune responses in HIV exposed and infected individuals as well as SIV vaccine studies in macaques suggest that it is unlikely that vaccine approaches that stimulate a single arm of the immune system will provide effective prote | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| UNIVERSITY OF ROCHESTER | $422,313 | Grant | Trans-NIH Recovery Act Research Support: Neisseria gonorrhoeae is the causative agent of gonorrhea, one of the most prevalent infectious diseases in this country. In addition to local infection, manifested as urethritis or cervicitis, the gonococcus can cause serious complications, including pel | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF NEBRASKA | $375,670 | Grant | Trans-NIH Recovery Act Research Support: This research proposal details our plan to establish the proof of concept that will support a subsequent R01 application to perfect and extend our methodology to expedite the functional and therapeutic analysis of hypothetical proteins identified by genom | Health and Human Services, Department of / National Institutes of Health | 5/06/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $432,440 | Grant | Trans-NIH Recovery Act Research Support: This is a two year award to analyze the methylcitrate cycle in Candida glabrata, an important human pathogen. This cycle is a fungal specific cycle important in detoxification of propionyl-CoA by C. glabrata. Propionyl-CoA is a byproduct of fatty acid ?-o | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| SAINT LOUIS UNIVERSITY | $430,494 | Grant | Trans-NIH Recovery Act Research Support: HIV causes AIDS in humans. Integration of HIV DNA by integrase into chromosomes is necessary for virus replication which cause AIDS. We investigate the mechanisms associated with integration and prevention of integration by clinical inhibitors. | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $363,490 | Grant | Trans-NIH Recovery Act Research Support: This project is being supported with funds from the American Recovery and Reinvestment Act, which may involve a reduction in the research aims and scope. If necessary, a revised abstract will be posted soon and this notice removed. DESCRIPTION (provided | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) | $427,600 | Grant | Trans-NIH Recovery Act Research Support: A major risk associated with implanted medical devices is their high rate of infection. Bacteria that colonize medical devices form matrix-encased biofilms that resist antimicrobial therapy and are often difficult or impossible to eradicate. The extracell | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF PITTSBURGH THE | $398,499 | Grant | Trans-NIH Recovery Act Research Support: The overall purpose of the award is to understand hepatitis C virus (HCV) life cycle and the HCV-associated steatosis with implications for the development of novel antiviral therapeutics. HCV infection can cause many liver diseases including acute and c | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| HEALTH RESEARCH, INC. | $427,076 | Grant | Trans-NIH Recovery Act Research Support: To analyze how immune responses generated against respiratory viral infection impact immunological and pathological responses to a subsequent pulmonary bacterial infection. Our goal is to identify the molecules and pathways involved in increased susceptib | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $445,294 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this project is to understand how natural killer T (NKT) cells recognize and respond to microorganisms in the respiratory mucosa. We have previously shown that NKT cells in the lungs play a critical role in the development of airway | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $431,750 | Grant | Trans-NIH Recovery Act Research Support: This award will investigate the mechanisms regulating the maintenance of hyporesponsiveness in mucosal T cells and the environmental signals that enable this normally quiescent mucosal T cell to respond when needed. Signal transduction emanating from the | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $428,948 | Grant | Trans-NIH Recovery Act Research Support: The mucosal surfaces of the body are the portal of entry for many pathogenic micro- organisms yet most licensed vaccines are delivered parenterally and are ineffective at inducing mucosal immune responses. In addition, exposure of mucous membranes to most | Health and Human Services, Department of / National Institutes of Health | 9/26/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $415,250 | Grant | Trans-NIH Recovery Act Research Support: Peripheral induction of antigen-specific Foxp3+CD4 T cells, or regulatory T cells (Tregs), is a potential pathway to treat autoimmune diseases. It is also represents an undesirable outcome of the immune response, which limits recovery from chronic infecti | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $407,500 | Grant | Trans-NIH Recovery Act Research Support: Legionella pneumophila (Legionella) is the causative agent of a severe pneumonia called Legionnaires' disease. Legionnaires' disease affects mainly the elderly and immune-compromised individuals. Each year, 8,000-18,000 people with legionellosis are hospi | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| BROWN UNIVERSITY IN PROVIDENCE IN STATE OF RI AND PROVIDENCE PLANTATIONS | $435,741 | Grant | Trans-NIH Recovery Act Research Support: Neutrophil priming is an integral aspect of a well-regulated inflammatory response and is the first step in controlling microbial infection and repair of injury. In this model, an initial injury primes neutrophils such that a secondary insult, which would | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| CHILDREN'S RESEARCH INSTITUTE | $473,000 | Grant | Trans-NIH Recovery Act Research Support: Mucin glycoproteins (mucins) protect the lung against pathogens and environmental toxins. Mucins are overproduced in the airways of patients with chronic lung diseases, which contributes markedly to patient morbidity and mortality. Inflammatory mediators | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $407,405 | Grant | Trans-NIH Recovery Act Research Support: Protein kinases are important regulators of cell proliferation, migration, and differentiation. Cancer cells of many types over-express protein kinases. Drugs that inhibit specific protein kinases are now used to treat some human cancers. Anti-parasite dr | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF ARIZONA | $532,510 | Grant | Trans-NIH Recovery Act Research Support: d-Limonene, a monocyclic monoterpene, is a major component in the essential oils of citrus fruits. Oral feeding of d-limonene has been shown to prevent carcinogen-induced rat mammary carcinoma during the initiation and promotion stages as well as cause si | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF CENTRAL FLORIDA | $355,763 | Grant | Trans-NIH Recovery Act Research Support: The assessment of volumetric change of enhancing tissue is regarded as an important parameter used by clinicians when seeking to monitor the response of brain neoplasms to therapy. Unfortunately, direct computation of enhancing volume requires the manual | Health and Human Services, Department of / National Institutes of Health | 4/27/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $419,721 | Grant | Trans-NIH Recovery Act Research Support: Quality of life (QOL) changes by the week, the day, and the hour; how these moments affect us becomes our QOL. In medical research, we use standardized questionnaires that usually try to summarize these changing states and feelings over a long period. T | Health and Human Services, Department of / National Institutes of Health | 5/13/2009 |
| PALO ALTO MEDICAL FOUNDATION FOR HEALTH CARE, RESEARCH AND EDUCATION (INC) | $358,751 | Grant | Trans-NIH Recovery Act Research Support: Prostate cancer is the second most frequent cause of cancer mortality for men. Definitive, comparative treatment outcome data for localized prostate cancer are lacking. Men must choose among treatment options that may offer similar mortality benefits bu | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| MAYO CLINIC | $391,855 | Grant | Trans-NIH Recovery Act Research Support: Prostate cancer is a leading cause of cancer related morbidity and mortality in US males. Despite initial treatments with curative intent for localized stage (surgery or radiation) approximately one third patients will progress to advanced stages. This h | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| SRI INTERNATIONAL | $443,864 | Grant | Trans-NIH Recovery Act Research Support: The present award is being utilized to develop an all optical platform to form lipid bilayers from water-in-oil emulsions using an inverted fluorescence microscope Optical radiation will be used to mobilize water droplets coated with a lipid monolayer and | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | $363,000 | Grant | Trans-NIH Recovery Act Research Support: BCR/ABL fusion tyrosine kinase results from t(9;22) reciprocal chromosomal translocation and is leukemogenic only when expressed in a hematopoietic stem cells (HSCs) with self-renewal capacity thereby inducing leukemia stem cell (LSC). LSCs are capable to | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| OKLAHOMA MEDICAL RESEARCH FOUNDATION | $401,392 | Grant | Trans-NIH Recovery Act Research Support: The specific aims are to assess tumor marker specific nanoprobes as potential therapeutics and diagnostics. Specific Aim 1 is to assess tumor marker specific magnetite nanoprobes in their ability to detect markers associated with tumor malignancy and angi | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $591,500 | Grant | Trans-NIH Recovery Act Research Support: Health Relatedness: Over 400,000 Americans are afflicted with multiple sclerosis (MS), with severe disability ultimately affecting ~85% of the total MS population. Disability in MS is primarily due to demyelination and axonal injury. Axonal injury itself | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $680,522 | Grant | Trans-NIH Recovery Act Research Support: Huntington's disease (HD) is a chronic neurodegenerative disease resulting from an autosomal dominant mutation in the gene for the huntingtin protein (htt). It is unknown, however, how mutant huntingtin causes a stereotyped pattern of neuronal loss, nor w | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| BAYLOR COLLEGE OF MEDICINE | $800,001 | Grant | Trans-NIH Recovery Act Research Support: Generate Shank3 conditional knock-out mice line. This proposal is responsive to RFA-MH-09-170, the Recovery Act Limited Competition: Research to Address the Heterogeneity in Autism Spectrum Disorders (R01). As noted in the RFA, Autism spectrum disorders ( | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $384,896 | Grant | Trans-NIH Recovery Act Research Support: Methamphetamine (METH) is an addictive psychostimulant with extremely high relapse rates. Effective pharmacotherapies to treat METH addiction, and in particular to counter relapse have not yet been developed. Research in animal models implicates the corti | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| RAND CORPORATION, THE | $158,664 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Recent years have seen prominent calls for quality improvement within the health-care sector. Nevertheless, the social value of quality turns on its benefits and costs. The purpose of this two-year research project is | Health and Human Services, Department of / National Institutes of Health | 5/18/2009 |
| SUTTER WEST BAY HOSPITALS | $121,459 | Grant | Trans-NIH Recovery Act Research Support: Our primary aim is to assess the association of mtDNA polymorphisms and heteroplasmy with active energy expenditure and resting metabolic rate in the elderly. We will carry out our primary aim in a test of healthy samples from the Health, Aging and Body C | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| NORTH DAKOTA STATE UNIVERSITY | $143,500 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Project Summary Muscle wasting syndrome and cachexia are associated with many degenerative diseases, like cancer, AIDS, and other systemic diseases. Muscular atrophy is primarily a result of increased protein degradati | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| SAINT LOUIS UNIVERSITY | $147,075 | Grant | Trans-NIH Recovery Act Research Support: Elucidation of the molecular mechanisms whereby PARP-1 regulates IL-10 gene expression will enable us identify key steps in the regulatory pathway that may be explored as potential targets of therapeutic intervention in juvenile arthritis. Moreover, the p | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| DUKE UNIVERSITY | $156,000 | Grant | Trans-NIH Recovery Act Research Support: During embryonic development, a single-layered ectodermal cell layer transforms into a multi- layered epidermis. The multi-layered or stratified architecture of the epidermis is essential for its barrier function - allowing it to prevent both dehydration | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF OKLAHOMA | $150,000 | Grant | Trans-NIH Recovery Act Research Support: Gene therapy has emerged as a promising strategy for bone repair and regeneration. The key to its success is to deliver the genes of interest to the target bone fracture site that can be expressed at suitable levels. Both ex vivo and in vivo gene therapy | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| VIRGINIA COMMONWEALTH UNIVERSITY | $448,500 | Grant | Trans-NIH Recovery Act Research Support: Tobacco smoking is addictive and data from epidemiological studies have suggested that genetic factors play an important role in smoking and nicotine addiction. Multiple recent studies indicate that variants in the CHRNA5/CHRNA3/ CHRNB4 locus on chromosom | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $231,750 | Grant | Trans-NIH Recovery Act Research Support: Bone degenerative diseases such as osteoporosis, periodontitis, and rheumatoid arthritis are major health care concerns for the elderly population that is rapidly increasing in the US. An osteoporotic fracture can cause significant morbidity and mortality | Health and Human Services, Department of / National Institutes of Health | 4/29/2009 |
| UNIVERSITY OF FLORIDA | $146,049 | Grant | Trans-NIH Recovery Act Research Support: Our long-term goal is to elucidate the causes and pathophysiology of osteonecrosis of the jaw (ONJ) in order to create the basis for new effective strategies for prevention and treatment. The objectives of this proposal are to develop an animal model for | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $235,125 | Grant | Trans-NIH Recovery Act Research Support: Activating mutations in FGFR2 cause craniosynostosis syndromes such as Apert and Crouzon syndromes. Recent genetic evidence has also indicated that the ERK MAPK pathway and immediate early genes play critical roles in the regulation of bone formation. The | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $416,966 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Cleft palate is a highly prevalent craniofacial malformation that affects approximately one in 700 newborns in the U.S. Studies on small numbers of children have raised the concern that repair of the cleft palate incre | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| NORTHWESTERN UNIVERSITY | $334,042 | Grant | Trans-NIH Recovery Act Research Support: Atrial fibrillation (AF) is the commonest rhythm disturbance of the heart, and is a major cause of serious morbidity such as congestive heart failure and cerebrovascular embolism (`stroke'). More recently, AF has been found to be associated with significa | Health and Human Services, Department of / National Institutes of Health | 5/13/2009 |
| UNIVERSITY OF PITTSBURGH THE | $424,679 | Grant | Trans-NIH Recovery Act Research Support: As a systemic disease of the vessel wall, atherosclerosis occurs in carotid, coronary and peripheral arteries, and has contributes to significant morbidity and mortality in the adult population. Recent advances in basic sciences have established a fundame | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF PITTSBURGH THE | $393,965 | Grant | Trans-NIH Recovery Act Research Support: Lanthanide Containing ZnS Nanoparticles The overall objective of the research is to develop a novel family of luminescent nanoparticles that emit visible or near infrared light and are specifically designed to operate as fluorescent reporters in a broad | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $411,664 | Grant | Trans-NIH Recovery Act Research Support: Numerous studies have shown associations of ambient particulate matter (PM) air pollution with cardiovascular hospital admissions and mortality. The causal pollutant components and physiologic mechanisms for these associations are not fully understood. Th | Health and Human Services, Department of / National Institutes of Health | 5/19/2009 |
| UNIVERSITY OF TEXAS AT EL PASO | $407,079 | Grant | Trans-NIH Recovery Act Research Support: This application is a new investigator-initiated (NIEHS PA-06-181) exploratory/developmental research grant (R21) that addresses the need for understanding the impact of long-term ambient air pollution exposure on a therogenesis. Ambient air pollution is | Health and Human Services, Department of / National Institutes of Health | 9/19/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $446,782 | Grant | Trans-NIH Recovery Act Research Support: The project is aimed at developing new image analysis techniques to characterize brain atrophy in the R6/2 mouse line, a mouse model of Huntington's disease (HD). Atrophy of specific brain structures is known to be an important marker of HD and other | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $355,108 | Grant | Trans-NIH Recovery Act Research Support: The work is complete and the remaining balance of the award will be returned to NIH. Dendrites and axons extend long distances from the neuronal cell body and so can be damaged independently from it. It is known that axons possess their own active dege | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $340,686 | Grant | Trans-NIH Recovery Act Research Support: Malignant glioma is the most aggressive and deadly brain tumor in adults. Despite the improvement of imaging technology and surgical removal of the tumors significantly reduces the mortality of malignant glioma, how to enhance the sensitivity to radiation | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| BAYLOR COLLEGE OF MEDICINE | $140,160 | Grant | Trans-NIH Recovery Act Research Support: This project is focused on elucidating molecular mechanisns of skeletal abnormalities in tricho-rhino-phalangeal syndrome.Mutations of the human TRPS1 gene cause a dominantly inherited skeletal dysplasia tricho-rhino-phalangeal syndrome (TRPS). Although | Health and Human Services, Department of / National Institutes of Health | 6/10/2009 |
| UNIVERSITY OF PITTSBURGH THE | $15,729 | Grant | Trans-NIH Recovery Act Research Support: Primary liver cancers are highly malignant tumors in human and their incidences are rising in the United States. The overall survival of patients with liver cancer is grim and currently no efficient chemoprevention is available. The current proposal eval | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $154,500 | Grant | Trans-NIH Recovery Act Research Support: Tobacco smoke is the single most preventable risk of cancer and is responsible for lung cancer being the highest in incidence worldwide. Research on the association between tobacco and cancer relied on questionnaire data for tobacco exposure assessment wh | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| SOUTH CAROLINA RESEARCH FOUNDATION | $150,466 | Grant | Trans-NIH Recovery Act Research Support: DEVELOPMENT AND EVALUATION OF SPATIAL SURVIVAL MODELS General Aims The general aim of this project is to develop new and flexible statistical methods to estimate survival probabilities within spatial cancer survival data. We are interested in developing s | Health and Human Services, Department of / National Institutes of Health | 6/19/2009 |
| NORTHWESTERN UNIVERSITY | $120,297 | Grant | Trans-NIH Recovery Act Research Support: Non-Hodgkin lymphoma (NHL) is the fifth most common cause of cancer death in the United States with a five-year survival rate of 64% overall (1996-03). Despite the promise of prognostic immune signatures, measurement of gene expression using microarrays i | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $162,541 | Grant | Trans-NIH Recovery Act Research Support: Adjuvant chemotherapy and tamoxifen have been shown to reduce the risk of contralateral breast cancer (CBC) among women with a previous history of breast cancer. It is well recognized that not all individuals metabolize drugs with the same efficiency or e | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $163,500 | Grant | Trans-NIH Recovery Act Research Support: Telomere length measured in peripheral blood leucocytes (PBLs) has emerged as a principal biomarker of aging and cancer risk. Telomeres are TTAGGG repeat complexes at the end of chromosomes that protect against degradation, fusion, and aberrant recombinat | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| BOSTON MEDICAL CENTER CORPORATION | $165,906 | Grant | Trans-NIH Recovery Act Research Support: The transition from adolescence to young adulthood is marked by declines in healthful behaviors such as diet, physical activity, and increases in obesity, thereby establishing early patterns of unhealthful behaviors in mid-adulthood that can lead to incre | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| MICHIGAN STATE UNIVERSITY | $152,000 | Grant | Trans-NIH Recovery Act Research Support: During the past 20 years, obesity has risen at an epidemic rate in the United States. It is anticipated that with increased obesity colon cancer cases will increase; therefore, research regarding how obesity increases the risk of colon cancer is extremely | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $151,750 | Grant | Trans-NIH Recovery Act Research Support: While some individuals are able to casually use a drug without it interfering with their day-to-day activities, others become addicted, unable to shift their thoughts and actions away from drugs and drug-associated stimuli. The factors underlying these in | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| CLAREMONT GRADUATE UNIVERSITY | $226,321 | Grant | Trans-NIH Recovery Act Research Support: This project seeks to understand the neural basis involved in implicit associative processes through the imaging (fMRI) of drug-relevant memory associations. Complex associative learning and memory processes influenced by reinforcing drug use result in ne | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| WASHINGTON UNIVERSITY, THE | $152,000 | Grant | Trans-NIH Recovery Act Research Support: Characterizing the 3-year course of cannabis involvement in NESARC Cannabis is the most commonly used illegal psychoactive substance in the United States and in developed nations. For instance, in the U.S., over 40 percent of 12th graders reporting a life | Health and Human Services, Department of / National Institutes of Health | 5/04/2009 |
| NATIONAL OPINION RESEARCH CENTER | $323,537 | Grant | Trans-NIH Recovery Act Research Support: This proposal concerns the study of Men's Assessment of Social Support and Risk Networks. Unfortunately, relatively little is known about the particular social consequences of the aging of the HIV/AIDS population, either for the challenges faced by person | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| WAKE FOREST UNIVERSITY | $144,541 | Grant | Trans-NIH Recovery Act Research Support: Research into the role of neurotransmitter systems in the reinforcing effects of cocaine has traditionally focused on monoamines; however recent studies in rodents indicate a strong involvement of glutamatergic mechanisms, particularly during abstinence. | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| MCLEAN HOSPITAL CORPORATION, THE | $158,000 | Grant | Trans-NIH Recovery Act Research Support: Human genetic studies have linked polymorphisms in the gene encoding the GABAA receptor ?2 subunit, GABRA2, to substance abuse, but neuronal mechanism and brain regions involved are still unknown. Recent experimental evidence suggests that a global deleti | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | $332,560 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Despite decades of committed research, no agents are clinically available to combat psychostimulant abuse and addiction. This prodigious void can be linked to sparse information on the 3-D structure and function of the | Health and Human Services, Department of / National Institutes of Health | 5/18/2009 |
| THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | $151,588 | Grant | Trans-NIH Recovery Act Research Support: Anandamide (AEA) is a naturally occurring ligand that binds to cannabinoid receptors and is widely distributed in the body, particularly the nervous system. Although AEA was described in 1992, the pathway for its synthesis has not been definitively determ | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $431,855 | Grant | Trans-NIH Recovery Act Research Support: IMAGING VARENICLINE EFFECTS ON NICOTINE & DOPAMINE: GENE MODULATION Nicotine dependence (ND) is a complex behavior governed by genetic and environmental determinants. In fact specific variations in the genes that influence nicotinic receptors have been as | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF WASHINGTON | $127,719 | Grant | Trans-NIH Recovery Act Research Support: DNA microarrays are in principle particularly well suited for real-time identification of known or related species. Microarrays are inherently parallel, as hundreds to thousands of nucleic acid signatures can be probed for in a single hybridization assay | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $154,383 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The goal of the proposed research is to examine how workers in the United States encounter multiple negative experiences at work, and how the accumulation of these experiences over the career is associated with their h | Health and Human Services, Department of / National Institutes of Health | 8/24/2009 |
| CLAREMONT GRADUATE UNIVERSITY | $72,631 | Grant | Trans-NIH Recovery Act Research Support: Over 17% of U.S. adolescents are considered overweight. The proposed study will advance our understanding of the dynamic relationship of overweight status and psychosocial adjustment problems during the period of pubertal transition, which will have impor | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| NATIONAL JEWISH HEALTH | $156,000 | Grant | Trans-NIH Recovery Act Research Support: The interactive acute health effects of environmental tobacco smoke (ETS) and ambient fine particulate matter (PM2.5) exposure on health of children with asthma will be analyzed. The results will allow for a better understanding about how children with lo | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| RAND CORPORATION, THE | $170,262 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Despite the fact that contraceptives have the potential to nearly eliminate pregnancy and sexually transmitted diseases (STDs), data from the 2002 National Survey of Family Growth show that almost half the pregnancies | Health and Human Services, Department of / National Institutes of Health | 7/24/2009 |
| WESLEYAN UNIVERSITY | $159,890 | Grant | Trans-NIH Recovery Act Research Support: The investigators' work to date has identified two dynamic mesodermal domains in the developing vertebrate embryo. The primaxial domain is populated exclusively by cells from the somites. The abaxial domain is made up of myoblasts from the somites and con | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF PUERTO RICO AT CAROLINA | $126,000 | Grant | Trans-NIH Recovery Act Research Support: To provide support for initiatives funded under The American Recovery and Reinvestment Act of 2009 (ARRA). These projects will provide economic stimulus to the nation while furthering the NIH mission to uncover new knowledge that will lead to better healt | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF OKLAHOMA | $146,500 | Grant | Trans-NIH Recovery Act Research Support: Pressure ulcers significantly affect quality of life and overall healthcare costs of wheelchair users with spinal cord injury (SCI). Current clinical practice includes using wheelchair power seat function (PSF) to attain specific seating angles, durations | Health and Human Services, Department of / National Institutes of Health | 5/04/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $146,438 | Grant | Trans-NIH Recovery Act Research Support: Idiopathic Pulmonary Fibrosis (IPF) is a deadly disease without a clearly-defined etiology. Because the incidence increases with age, it is plausible that environmental effects may be important. Recent data indicate re-expression of developmental gene sig | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $171,375 | Grant | Trans-NIH Recovery Act Research Support: Microarray analysis is widely expected to further our understanding of disease phenotypes and yield robust gene expression signature based predictors of clinical outcome. However, as it has been frequently demonstrated in the literature, insufficient unde | Health and Human Services, Department of / National Institutes of Health | 6/23/2009 |
| UNIVERSITY OF ROCHESTER | $153,584 | Grant | Trans-NIH Recovery Act Research Support: Ataxia Telangiectasia (AT) is a genetic disorder that surprisingly manifests itself only in certain tissues. This tissue preference is especially relevant to the AT-affected CNS, in which degeneration of the cerebellar cortex and subsequently many of its | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | $955,749 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this research is to design and synthesize novel Beta-lactam containing compounds to use as chemical probes to better understand the biology of glutamate transporter subtype 1(GLT-1) upon activation by the Beta -lactam antibiotic ceftriaxone | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| DUKE UNIVERSITY | $87,655 | Grant | Trans-NIH Recovery Act Research Support: The cerebellum is critical for motor coordination and cognitive function. Granule neurons are a key component of cerebellar circuitry and are thought to represent the cell of origin for the pediatric brain tumor medulloblastoma. While the development of g | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| EAST TENNESSEE STATE UNIVERSITY | $214,500 | Grant | Trans-NIH Recovery Act Research Support: F1Fo-ATP synthase is the smallest known biological motor, found from bacteria to man. It is the fundamental means of cell energy production in animals, plants, and almost all microorganisms in the form of adenosine triphosphate (ATP) from adenosine diphos | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| MIDWESTERN UNIVERSITY | $212,820 | Grant | Trans-NIH Recovery Act Research Support: This Academic Research Enhancement Award (AREA) grant was provided from the National Institutes of Health (National Institute of Arthritis and Musculoskeletal and Skin Diseases) to fund a grant application titled 'Manzamine A as an anti-inflammatory treat | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $231,000 | Grant | Trans-NIH Recovery Act Research Support: This proposal will investigate the role of exercise (mechanical loading) during growth on lifelong skeletal health. Exercise is a commonly advocated intervention for osteoporosis as the skeleton is mechanosensitive and can adapt to loading. However, a dis | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| MARQUETTE UNIVERSITY | $223,500 | Grant | Trans-NIH Recovery Act Research Support: ATP produced within the mitochondrial matrix through a process termed oxidative phosphorylation (OXPHOS) is transported out of the mitochondria to the rest of the cell via a metabolite carrier proteins termed the ADP/ATP carrier (AAC) family located withi | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| MONTCLAIR STATE UNIVERSITY STUDENT GOVERNMENT ASSOCIATION SCHOLAR, THE | $199,356 | Grant | Trans-NIH Recovery Act Research Support: The goal of this research is to understand the processes of forming a temproal interpretation of sentences, and how these processes are related to the processing of basic content. The knowledge that is gained will provide a foundation for improving the he | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| DENISON UNIVERSITY | $196,312 | Grant | Trans-NIH Recovery Act Research Support: This grant is funding primary research in developmental neurobiology that involves undergraduate students in the research process. | Health and Human Services, Department of / National Institutes of Health | 8/15/2009 |
| CHARLES DREW UNIVERSITY OF MEDICINE AND SCIENCE | $206,420 | Grant | Trans-NIH Recovery Act Research Support: Investigation of the effects of increased neurosteroid exposure on the maturing cerebral cortex highlights the importance of the downstream effects of stress on cortical development. In particular, nonspecific stress is the most consistent factor recogniz | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $402,808 | Grant | Trans-NIH Recovery Act Research Support: Endocytosis and cell signaling are important for viability of eukaryotes. In Trypanosoma brucei, little is known about cell signaling because the major receptors studied in model eukaryotes are unrecognizable in the parasite genome. T. brucei has a glycos | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $364,421 | Grant | Trans-NIH Recovery Act Research Support: Consistent, albeit moderate alcohol consumption in human adults results in permanent alterations in the cerebellum that discretely disrupt motor functions and become more pronounced with age. This is a major health concern as the aging population continue | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $215,610 | Grant | Trans-NIH Recovery Act Research Support: This study will investigate the effect of alcohol exposure during pregnancy on an organelle termed mitochondria which play a respiratory role in cells. We will also investigate the role of molecules that have a protective effect against alcohol exposure | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $410,907 | Grant | Trans-NIH Recovery Act Research Support: Chronic alcohol abuse has a variety of pathological consequences including damage to liver, brain and other organs. Some of these pathological effects can be attributed to ethanol metabolism. Ethanol is metabolized to acetaldehyde by the alcohol dehydroge | Health and Human Services, Department of / National Institutes of Health | 5/22/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $345,644 | Grant | Trans-NIH Recovery Act Research Support: This proposal explores consequences of chronic alcohol (ethanol; EtOH) exposure and withdrawal on sex- specific astrocyte activation, expression and function. Chronic EtOH abuse is associated with neurotoxicity and reactive astrogliosis, but the mechanism | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $418,235 | Grant | Trans-NIH Recovery Act Research Support: This project is being supported with funds from the American Recovery and Reinvestment Act, which may involve a reduction in the research aims and scope. If necessary, a revised abstract will be posted soon and this notice removed. DESCRIPTION (provided | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| UNIVERSITY OF WASHINGTON | $351,780 | Grant | Trans-NIH Recovery Act Research Support: Werner syndrome (WS) is an 'adult-onset' genetic disorder characterized by multiple features consistent with accelerated aging (i.e., a 'segmental progeroid syndrome'). An aged appearance and common age-related disorders such as type 2 diabetes mellitus o | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF KENTUCKY | $334,866 | Grant | Trans-NIH Recovery Act Research Support: Fibromyalgia (FM) is a clinical state of widespread musculoskeletal pain with multiple tender points that is most common in postmenopausal women. Fatigue, particularly post-exertional, is an additional hallmark of the syndrome. FM likely has no single eti | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $375,350 | Grant | Trans-NIH Recovery Act Research Support: An underlying viral infection can modulate secondary pathogen encounters in different ways. For instance, virus infections such as HIV or Measles are associated with immunosuppression and enhanced susceptibility to opportunistic infections, resulting in m | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | $414,744 | Grant | Trans-NIH Recovery Act Research Support: The type III secretion system (TTSS) is essential for the pathogenesis of a number of gram-negative human pathogens, including three Yersinia species; Y. pseudotuberculosis and Y. enterocolitica, that cause infection of intestinal lymphoid tissues, and Y. | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF ARIZONA | $0 | Grant | Trans-NIH Recovery Act Research Support: The Gram positive bacterium Arcanobacterium haemolyticum, is an under-recognized cause of pharyngitis and disseminated disease, including meningitis, osteomyelitis and endocarditis. To date, no molecular characterization of A. haemolyticum virulence facto | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| UNIVERSITY OF ROCHESTER | $422,125 | Grant | Trans-NIH Recovery Act Research Support: Epidemic typhus, also known as Gaol fever, Jail fever, or Famine fever, is caused by the Gram-negative bacterium Rickettsia prowazekii. This louse-borne disease has been responsible for devastating widespread epidemics throughout history, especially durin | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE | $284,342 | Grant | Trans-NIH Recovery Act Research Support: The objective of this study is to identify mosquito genes critical for arbovirus replication. In particular, antiviral genes that antagonize viral replication in mosquitoes are of interest since these genes can be targeted for control of virus transmissio | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $470,438 | Grant | Trans-NIH Recovery Act Research Support: Role of ICOS-B7h Regulatory Costimulatory Pathway in Fetomaternal Tolerance The fetus has paternal antigens which can evoke strong allogeneic T cell responses. However, in general the semi-allogeneic fetus is not usually rejected indicating the existence | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY | $519,475 | Grant | Trans-NIH Recovery Act Research Support: Activation of NKT cells by cytomegalovirus: The innate immune response to pathogens is critical for the control of infection prior to the development of adaptive immunity. NKT cells with an invariant T cell antigen receptor (TCR) ? chain (iNKT cells) are | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| PURDUE UNIVERSITY | $365,884 | Grant | Trans-NIH Recovery Act Research Support: To evaluate the potential for developing an antiviral chemotherapeutic strategy based on the intrinsic defense mechanism of human cells: mutagenesis of single-stranded DNA by cytidine deaminase APOBEC3G (A3G). Human immunodeficiency virus 1 (HIV-1) counte | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $423,500 | Grant | Trans-NIH Recovery Act Research Support: Vaccination for protection against sexually transmitted diseases such as acquired immunodeficiency syndrome (AIDS) caused by human immunodeficiency virus (HIV) infection should concentrate on inducing strong antigen-specific humoral and cellular immune re | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $420,500 | Grant | Trans-NIH Recovery Act Research Support: Helicobacter pylori is a bacterium that commonly infects the stomach, where it causes inflammation (gastritis) in all individuals and peptic ulcer disease or gastric cancer in some. The most intensively studied bacterial factor associated with the develop | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $470,104 | Grant | Trans-NIH Recovery Act Research Support: Group A Streptococcus (GAS) employs multiple defense strategies to resist killing by reactive oxygen species (ROS) formed either by reduction of atmospheric oxygen or by phagocytes upon activation of the host inflammatory response. These defenses seem to | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $382,129 | Grant | Trans-NIH Recovery Act Research Support: The purpose of the proposed study is to explore the benefits of Exercising Together - a partnered strength training program for married couples coping with prostate cancer - on the physical and emotional health of prostate cancer survivors (PCS) and their | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | $835,560 | Grant | Trans-NIH Recovery Act Research Support: Malignant gliomas are the most common and lethal adult primary brain tumors. Despite aggressive therapeutic interventions, these tumors are difficult to eradicate due to their diffusely infiltrative growth pattern and frequent resistance to chemotherapeut | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| TEXAS A&M UNIVERSITY SYSTEM,THE | $354,529 | Grant | Trans-NIH Recovery Act Research Support: An individual's relevant health information is stored in multiple, independent sources (Institute of Medicine 2001). Therefore not all the clinical information useful to providers is available during a patient encounter, meaning decisions frequently occur | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| NORTHWESTERN UNIVERSITY | $369,050 | Grant | Trans-NIH Recovery Act Research Support: Epidemiological data demonstrates strong gender bias in hepatocellular carcinomas. This phenomenon cannot not be attributed to gender differences in life style factors. Moreover, there is no evidence implicating direct effect of sex hormones in the tumor | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $373,893 | Grant | Trans-NIH Recovery Act Research Support: The studies proposed here will examine a red marine algae extract for ability to inhibit the outgrowth of abnormal colonic epithelial cells. The source of the extract is the North Atlantic red algae, Lithothamnium coralliodides. The extract is rich in Ca2 | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| UNIVERSITY OF MARYLAND | $349,844 | Grant | Trans-NIH Recovery Act Research Support: Cancers of the large intestine cause more deaths in the United States than those arising in any other organ but the lung. Despite tremendous progress, the factors that initiate and promote the progression of neoplasia in the colon are incompletely underst | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC. | $404,030 | Grant | Trans-NIH Recovery Act Research Support: Treatment regimens and clinical intervention are driven by information obtained by ongoing patient monitoring. Current methods for protein biomarker detection are based on well established techniques, including gel electrophoresis and antibody-based detec | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $401,360 | Grant | Trans-NIH Recovery Act Research Support: Men and women respond differently to cocaine. Although epidemiological data show that more men than women abuse cocaine, there is preclinical and clinical evidence indicating that females are more vulnerable to its psychostimulant effects. Evidence also i | Health and Human Services, Department of / National Institutes of Health | 6/19/2009 |
| UNIVERSITY OF KENTUCKY | $735,682 | Grant | Trans-NIH Recovery Act Research Support: Drug abuse is a major public health concern and preventing the onset of problematic drug use has become a public health priority. Individuals classified as high sensation seekers are vulnerable to drug abuse and other risky behaviors that may result in po | Health and Human Services, Department of / National Institutes of Health | 6/19/2009 |
| DUKE UNIVERSITY | $724,692 | Grant | Trans-NIH Recovery Act Research Support: Although there is mounting evidence that strategically designed and targeted public service announcement (PSA) campaigns can reduce drug abuse by adolescents, a recent report by the Government Accountability Office concluded that the $1.4 billion National | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK INC | $425,198 | Grant | Trans-NIH Recovery Act Research Support: This revised R21 research grant application represents a partnership between the YMCA of Greater New York (YNY) and Columbia University. Over 2 years, the planned study will adapt a parent-involvement program for combined use with a previously tested prog | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| EAST TENNESSEE STATE UNIVERSITY | $377,503 | Grant | Trans-NIH Recovery Act Research Support: Young children with cleft lip and/or palate are at risk for speech and language delays associated with structural deficits despite early surgical repair. This study proposes to evaluate the effectiveness of an early intervention to facilitate speech and v | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| CATHOLIC HEALTHCARE WEST | $413,662 | Grant | Trans-NIH Recovery Act Research Support: This revised application is focused on the neural correlates of encoding and retrieving words in memory, with special focus on single-neuron responses to linguistic forms. While directly recording neural firing in human subjects as they perform perception | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF ROCHESTER | $292,233 | Grant | Trans-NIH Recovery Act Research Support: Brain function depends on precisely organized neural networks. A central problem in contemporary neuroscience has been to determine how the specific organization of synaptic inputs is established in the brain during development. Uncovering the identity of | Health and Human Services, Department of / National Institutes of Health | 6/11/2009 |
| NORTHEASTERN UNIVERSITY | $99,975 | Grant | Trans-NIH Recovery Act Research Support: Cultivating the uncultivable oral microflora | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $406,875 | Grant | Trans-NIH Recovery Act Research Support: Title: Lysyl Oxidase Control of TGF-b in Bone Description, Purpose and expected outcome: Lysyl oxidase (LOX) is a copper-dependent amine oxidase that oxidizes primary amine of peptidyl lysine/hydroxylysine of collagen and elastin to initiate a series of c | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $406,982 | Grant | Trans-NIH Recovery Act Research Support: Renal Processing of Albumin (ARRA) 2. Grant Title Renal Processing of Albumin (ARRA) Description of project. In 2003, I published a gel permeation/diffusion hypothesis (Smithies, 2003) postulating that the glomerular basement me | Health and Human Services, Department of / National Institutes of Health | 8/18/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $439,355 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Nephrotic Syndrome, characterized by massive proteinuria, hypoalbuminemia and edema, is one of the most frequently seen kidney diseases in children. Despite extensive research, the pathogenesis of this disease for the | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| NEW ENGLAND RESEARCH INSTITUTES, INC. | $384,287 | Grant | Trans-NIH Recovery Act Research Support: This project utilizes dietary data that was collected as part of the Boston Area Community Health (BACH) study to help fill knowledge gaps in the nutritional epidemiology of urogynecologic symptoms in a diverse, random community-based sample. Lower urinar | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF NEBRASKA | $535,463 | Grant | Trans-NIH Recovery Act Research Support: We developed an analytical protocol to purify and enrich biotinylated histones from human cells for subsequent analysis by mass spectrometry. Our protocol is based on acid xtraction of bulk histones from Jurkat cells, followed by fractionation of histones | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $484,000 | Grant | Trans-NIH Recovery Act Research Support: Our laboratory recently observed that during early growth and development (6 weeks to 6 months), mice develop increasing susceptibility to diverse forms of acute renal damage. Thus, whereas 1 month old mice are almost completely resistant to at least thr | Health and Human Services, Department of / National Institutes of Health | 5/12/2009 |
| UNIVERSITY OF UTAH, THE | $443,125 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Epithelial Na channels (ENaC) are expressed in the distal nephron where they serve as the final sites of Na reabsorption, thereby playing a key role in the regulation of extracellular fluid volume and blood pressure (B | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $431,750 | Grant | Trans-NIH Recovery Act Research Support: DNA nanoparticles self assemble from plasmid DNA and CK30 covalently linked to polyethylene glycol, and effectively transfect airway epithelium, retina, and neurons, but how they access cells has been obscure. Recently the surface receptor for these DNA n | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $408,271 | Grant | Trans-NIH Recovery Act Research Support: Phospholipase A2 (PLA2) are esterases that cleave glycerophospholipids, such as phosphatidylcholine, at the sn-2 ester bond, resulting in the release of a fatty acid and a lysophospholipid. Recent studies demonstrate that PLA2 expression and activity is i | Health and Human Services, Department of / National Institutes of Health | 4/30/2009 |
| UNIVERSITY OF CALIFORNIA, SANTA CRUZ | $398,903 | Grant | Trans-NIH Recovery Act Research Support: Miniaturization is a growing trend for bioanalytical instruments. Integration of sensing, detection, and manipulation functionalities in a small space promises a new generation of inexpensive, portable and highly sensitive equipment that can benefit publi | Health and Human Services, Department of / National Institutes of Health | 4/30/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $445,329 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Recent developments in two-photon laser scanning microscopy (TPLSM) in combination with improvement of fluorescent calcium indicators have opened an unprecedented possibility for in vivo imaging of neuronal activity. T | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $404,601 | Grant | Trans-NIH Recovery Act Research Support: The long-term objective of this work is to develop predictable and reproducible therapies for soft tissue regeneration using adipose stem cells (ASCs) formulated as 3-dimensional (3-D) multicellular aggregates. Currently available treatments are limited b | Health and Human Services, Department of / National Institutes of Health | 5/27/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $398,820 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): During the past decade our group has developed highly accelerated MR angiographic techniques based on undersampled radial acquisition, constrained reconstruction, and phase contrast imaging. Three basic modes of funct | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $446,875 | Grant | Trans-NIH Recovery Act Research Support: Apoptosis, 'programmed cell death,' is a cellular process exhibiting distinct biochemical and morphological changes, and is a key element of both normal and disease processes at the cellular level. As such, apoptosis is the subject of thousands of publica | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $414,435 | Grant | Trans-NIH Recovery Act Research Support: We concluded the work on the use of the asynchronous magnetic bead rotation (AMBR) sensor, for the measurement of individual cell growth. The AMBR sensor allows for the measurement of nanoscale growth dynamics of individual bacterial cells, over multiple | Health and Human Services, Department of / National Institutes of Health | 4/30/2009 |
| BAYLOR COLLEGE OF MEDICINE | $383,750 | Grant | Trans-NIH Recovery Act Research Support: Modulation of conjunctival goblet cell differentiation by immunoregulatory cells: This project will investigate the role of local immunoregulatory pathways on conjunctival epithelial homeostasis and the response of the conjunctival epithelium to the desic | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $404,375 | Grant | Trans-NIH Recovery Act Research Support: Antisocial Behavior, Genetics, & the Life Course (1R21-HD050261-01A2) The purpose of this research is to integrate genetic & life course models of criminal & otherwise antisocial behaviors from adolescence to young adulthood. Data come from four waves of | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| BAYLOR COLLEGE OF MEDICINE | $350,147 | Grant | Trans-NIH Recovery Act Research Support: 'We are developing a casual game played on a cell phone to teach effective food parenting practices using simulated parent-child interaction sequences with feedback and goal setting. | Health and Human Services, Department of / National Institutes of Health | 5/27/2009 |
| RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (INC) | $310,000 | Grant | Trans-NIH Recovery Act Research Support: American children from ethnic minority and low socioeconomic families have higher rates of poor health and higher mortality rates. Recent data suggest persistence or widening of these ethnic and socioeconomic differentials in health outcomes of US childre | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| EDUCATION, TRAINING, AND RESEARCH ASSOCIATES | $327,250 | Grant | Trans-NIH Recovery Act Research Support: The purpose of the study is to tackle the disparities among African American youth disproportionately affected by HIV/AIDS and other sexually transmitted infections by developing and testing a new intervention approach that addresses sexual risk behaviors | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $522,225 | Grant | Trans-NIH Recovery Act Research Support: To address whether small molecules can be identified that inhibit differentiation of hESCs in the absence of growth factors/cytokines for long-term self-renewal of hESCs (in a way conceptually similar to the function/mechanism of pluripotin in mESCs), we | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF SOUTH FLORIDA | $384,203 | Grant | Trans-NIH Recovery Act Research Support: Increasing numbers of hospice patients are admitted with heart failure as a primary diagnosis. Hospice provides comprehensive palliative care for both patients and their family members, but family caregivers often have unmet needs, even when receiving hos | Health and Human Services, Department of / National Institutes of Health | 8/07/2009 |
| RAND CORPORATION. THE | $467,571 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): We propose an innovative project that will identify and examine the compensatory strategies and resources used by low literate and low health-literate Latino diabetes patients when faced with literacy-demanding healthc | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $481,530 | Grant | Trans-NIH Recovery Act Research Support: Amyotrophic lateral sclerosis (ALS) is an enigmatic, horrific illness with a rapid course of progression for which there is little in the way of effective therapy. Finding objective markers for the progression of the disease is crucial for assessing the e | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| GEORGE MASON UNIVERSITY | $370,804 | Grant | Trans-NIH Recovery Act Research Support: Title: Reconstruction and Mapping of Human Brain Vasculature Description: This project aims at building digital reconstructions of the brain arterial network from magnetic resonance image data, characterizing the arterial morphometry, and constructing a v | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $464,635 | Grant | Trans-NIH Recovery Act Research Support: Parkinson's disease (PD) is a devastating neurodegenerative movement disorder characterized by a loss of dopamine-containing neurons of substantia nigra, which currently affects about 1.5 million people in the United States. While the causes of PD are unk | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $409,386 | Grant | Trans-NIH Recovery Act Research Support: Lafora disease (LD) is an autosomal recessive and incurable disease with characters of progressive myoclonus epilepsy (PME), severe neurological deterioration, and the accumulation of starch-like glycogen inclusion bodies (LB) mainly in the brain, muscle, | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| VIRGINIA COMMONWEALTH UNIVERSITY | $398,399 | Grant | Trans-NIH Recovery Act Research Support: This proposal plans to develop a technique that will permit the selective activation of individual subtypes of neurons by expressing in specific types of neurons genes of proteins that are capable of depolarizing only those neurons when the a | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| VIRGINIA COMMONWEALTH UNIVERSITY | $395,166 | Grant | Trans-NIH Recovery Act Research Support: Central nervous system (CNS) diseases and disorders represent the largest and fastest growing area of unmet medical need. Over 1.5 billion people worldwide, including over 100 million people in the US, suffer from CNS diseases or disorders. This project i | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| DREXEL UNIVERSITY | $421,769 | Grant | Trans-NIH Recovery Act Research Support: Amyotrophic lateral sclerosis (ALS) is characterized by the progressive and selective loss of motor neurons (MNs) in the motor cortex, brainstem, and spinal cord, resulting in death of patients 2-5 years after diagnosis. Glutamate-mediated excitotoxicity | Health and Human Services, Department of / National Institutes of Health | 6/15/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $410,249 | Grant | Trans-NIH Recovery Act Research Support: A wide array of inherited human diseases are caused by mutations in our mitochondrial DNA (mtDNA) genome and in mitochondrial genes encoded in the nuclear genome, but there are currently no effective therapies for these clinically devastating diseases. We | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| BAYLOR COLLEGE OF MEDICINE | $408,750 | Grant | Trans-NIH Recovery Act Research Support: 'Apoptosis is an orderly process of cellular elimination, which ensures complete disassembly and disappearance of damaged cells. Recently the concept of apoptotic cell elimination was expanded and programmed cell death is no longer viewed as an individual | Health and Human Services, Department of / National Institutes of Health | 6/15/2009 |
| THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | $407,094 | Grant | Trans-NIH Recovery Act Research Support: The multi-gene family of proteins called connexins form intercellular gap junctions that directly mediate signaling between adjacent cells. These cell-cell channels consist of two hemichannels or so-called connexons from adjacent cells. In addition to for | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| MAYO CLINIC JACKSONVILLE (A NONPROFIT CORPORATIO | $153,000 | Grant | Trans-NIH Recovery Act Research Support: Parkinson's disease (PD) is a prevalent, heterogeneous disorder with a complex, multifactorial etiology. The syndrome affects multiple systems with motor and non-motor features. In the past decade, many genes and specific mutations contributing to disease | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $412,782 | Grant | Trans-NIH Recovery Act Research Support: Amyotrophic lateral sclerosis is an adult onset motoneuron degenerative disease with a lifetime risk of ~1/1000 that affects an estimated 30, 000 adults in the US at any one time with ~5000 new cases/year. Approximately 80% of the cases are fatal 5 yrs af | Health and Human Services, Department of / National Institutes of Health | 5/01/2009 |
| UNIVERSITY OF ILLINOIS | $391,930 | Grant | Trans-NIH Recovery Act Research Support: The award title is G?Role of NCKX2 in the activation of toxic Zn2+ influx in ischemic neurons.G? Our ultimate goal is to improve the safety of cardiac surgeries that involve cardiopulmonary bypass. Over 700,000 such surgeries are performed in the US each | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $466,125 | Grant | Trans-NIH Recovery Act Research Support: During recent years, the vesicles of the endosomal/lysosomal (E/L) system have emerged as key sites for the regulation of many cellular functions. Their biological importance is exemplified by the occurrence of numerous lysosomal storage diseases (LSDs), | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| 4S3 BIOSCIENCE INC. | $336,682 | Grant | Trans-NIH Recovery Act Research Support: Translational grant to develop and test a fusion protein as a potential therapeutic for Myotonic dystrophy. Generation of the protein fusion will be followed by testing its activity in cell lines from human patients, ultimately testing its efficacy in mou | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| MCLEAN HOSPITAL CORPORATION, THE | $434,500 | Grant | Trans-NIH Recovery Act Research Support: Parkinson disease (PD) is caused by a progressive loss of the dopamine (DA) neurons in the substantia nigra pars compacta (SNc). Although the etiology of PD is still unknown, there is increasing evidence that it is a complex disorder influenced by a combi | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $608,125 | Grant | Trans-NIH Recovery Act Research Support: The ubiquitin E3 ligase Ube3a has been implicated in two severe neurological disorders, Angelman's syndrome (AS) and autism spectrum disorder caused by maternal 15q 11-13 duplication (15qASD). Cells from 15qASD and AS patients have excess and deficient UB | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $397,053 | Grant | Trans-NIH Recovery Act Research Support: This proposal, combining established biomedical engineering and clinical expertise from two institutions, seeks to develop and validate a portable, spatially-modulated imaging system with the long term goal of intra-operatively assessing surgical excision | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY ENTERPRISES CORPORATION AT CSUSB | $851,525 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of the proposed California State University, San Bernardino (CSUSB) Minority Drug Abuse Research Program (MIDARP) is to increase the quality and quantity of research on the CSUSB campus focused on drug abuse and addiction, particularly as | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $1,044,374 | Grant | Trans-NIH Recovery Act Research Support: Chronic disease is a major contributor to health disparities, and complex chronic disease (multiple chronic conditions requiring multiple providers) is increasingly common. Literature suggests that individuals with chronic disease receive less preventive | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $2,981,256 | Grant | Trans-NIH Recovery Act Research Support: Sickle cell anemia is a devastating disease affecting primarily African Americans. Our goals are to capture the genetic diversity that is likely to underlie the notoriously heterogeneous clinical course of this disease, and with this information, develop | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | $426,620 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Basophils are now recognized as critical effectors and immune modulators during Th2 mediated immune responses, such as allergic inflammations and parasite infections. Evidence suggests that basophils produce Th2 induci | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | $430,146 | Grant | Trans-NIH Recovery Act Research Support: Hantaviruses infect endothelial cells (ECs) and cause 2 vascular permeability-based diseases: Hemorrhagic Fever with Renal Syndrome (HFRS) and Hantavirus Pulmonary Syndrome (HPS). Pathogenic hantaviruses bind to a 53 residue PSI domain present at the apex | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $412,500 | Grant | Trans-NIH Recovery Act Research Support: Human noroviruses (HuNoVs) are the leading cause of gastroenteritis worldwide causing 23 million cases of gastroenteritis annually and substantial economic impacts in the US alone. The lack of an animal disease model (until recently) and routine cell cult | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $414,486 | Grant | Trans-NIH Recovery Act Research Support: This proposal will use the interferon-gamma binding protein from ectromelia virus (IFN-gBPECTV) to design new cytokine antagonists and improved research reagents with broad applications to many disciplines. Preliminary structural studies on IFN-gBPECTV h | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| RUSH UNIVERSITY MEDICAL CENTER | $412,500 | Grant | Trans-NIH Recovery Act Research Support: Schistosomiasis is an important tropical parasitic human disease. Although an effective anti-schistosome drug is in use, it is estimated that 200 million people are infected, 20 million individuals suffer severe disease symptoms, and 280,000 people die an | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF FLORIDA | $402,875 | Grant | Trans-NIH Recovery Act Research Support: Sj+?gren's syndrome (SjS) is a systemic autoimmune disease characterized primarily by salivary and lacrimal gland dysfunction. As with many autoimmune connective tissue diseases, there exists a sexual dimorphism in SjS with women affected 10- to 20-times | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $441,429 | Grant | Trans-NIH Recovery Act Research Support: Herpes simplex virus-1 (HSV-1) is human alphaherpesvirus that establishes a lifelong latent infection in peripheral nerve ganglia following primary infection. HSV-1 infections are generally benign, although its capacity for neurovirulence and neuroinvasiv | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $416,211 | Grant | Trans-NIH Recovery Act Research Support: Bacillus anthracis is the bacterium that causes the disease anthrax. Concern over its use as a bioweapon has renewed interest in elucidating mechanisms of how it causes disease. B. anthracis promotes its growth in the host through the production of lethal | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE | $415,250 | Grant | Trans-NIH Recovery Act Research Support: Information gleaned from recent studies with single-stranded, positive-sense RNA viruses pathogenic to humans and animals (polio and alphaviruses) and insects (flock house virus; FHV) revealed that the mechanism of genome packaging in these viral systems | Health and Human Services, Department of / National Institutes of Health | 5/28/2009 |
| THE VANDERBILT UNIVERSITY | $425,938 | Grant | Trans-NIH Recovery Act Research Support: Immunoreceptor-mediated activation of transcription factor NF-kB and MAP kinases (MAPKs) is essential for proper regulation of multiple genes involved in the innate and adaptive immune response to microbial pathogens. Prior experiments with transformed ce | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $430,749 | Grant | Trans-NIH Recovery Act Research Support: Schistosomiasis is a major tropical disease caused by parasitic flatworms called schistosomes. Although there is an effective drug against schistosomiasis, the mechanism by which it works is unclear. By understanding that mechanism, it may be possible to | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| UNIVERSITY OF IOWA, THE | $423,450 | Grant | Trans-NIH Recovery Act Research Support: The filoviruses, Ebola (EBOV) and Marburg (MARV), cause periodic hemorrhagic fever outbreaks in sub-Saharan Africa.-? Because of the high rates of mortality associated with these infections and high transmissibility of these viruses in the human populatio | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| WORCESTER POLYTECHNIC INSTITUTE | $439,943 | Grant | Trans-NIH Recovery Act Research Support: Tuberculosis is a leading health problem worldwide. Mycobacterium tuberculosis virulence is based on its capability to reside inside macrophages. At the center of its pathogenic strategy is the handling of involved heavy metals (Cu+, Zn2+, Fe2+, Mn2+, et | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC. | $459,000 | Grant | Trans-NIH Recovery Act Research Support: AKT, a phosphatidylinositol 3-kinase (PI3K)-dependent serine-threonine kinase, promotes glucose metabolism and survival of activated T cells and limits differentiation of regulatory T cells (Tregs). While AKT is critical for thymocyte development, some au | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| NEW YORK UNIVERSITY (INC) | $464,969 | Grant | Trans-NIH Recovery Act Research Support: An estimated 36 million people worldwide have Human Immunodeficiency Virus (HIV) infection, while over 300 million have Hepatitis B Virus (HBV) infection. Among those with HBV mono-infection, HBe seroconversion from the state of Hepatitis B e antigen (HBe | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $424,875 | Grant | Trans-NIH Recovery Act Research Support: T helper cells in lymphoid tissues adopt multiple cell fates that regulate inflammation. At the G-I mucosa, their dominant phenotype is of Treg cells. Mucosal adjuvants, by overriding the tolerant impact of mucosal Treg cells, are unique tools for dissect | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $420,698 | Grant | Trans-NIH Recovery Act Research Support: Trypanosomatids are protozoan hemoflagellates responsible for a variety of human diseases, including Chagas' disease, leishmaniasis, and African sleeping sickness, which account for nearly one million deaths per year. The unique genetic phenomena occurrin | Health and Human Services, Department of / National Institutes of Health | 5/20/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $522,225 | Grant | Trans-NIH Recovery Act Research Support: In light of the extreme mortality rates associated with human infection with avian influenza strains, the emergence of a pandemic influenza outbreak is of immense concern. Pandemic strains are thought to occur through the introduction of genetically dive | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| ST. JUDE CHILDREN'S RESEARCH HOSPITAL | $462,000 | Grant | Trans-NIH Recovery Act Research Support: In humans, IL4 and TH2 cells critically impact a wide array of diseases, a prime example of which is bronchial asthma where genetic association studies have repeatedly identified both the gene locus encoding IL4 and IL13 (5q25-31) and several mutations in | Health and Human Services, Department of / National Institutes of Health | 7/23/2009 |
| MONTANA STATE UNIVERSITY, INC | $391,875 | Grant | Trans-NIH Recovery Act Research Support: The specific hypothesis behind the proposed research is that the prion agent can be shed from olfactory neurons into nasal secretions and the amount of prion infectivity released into nasal secretions will be enhanced under conditions that promote disrupt | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| DUKE UNIVERSITY | $343,204 | Grant | Trans-NIH Recovery Act Research Support: Clinical data support the concept that both normal stem cells and leukemia stem cells exhibit multiple drug resistance. However, it is unclear how mechanisms for drug resistance might interrelate with stem cell physiology. Our preliminary studies have exp | Health and Human Services, Department of / National Institutes of Health | 4/30/2009 |
| EASTERN MICHIGAN UNIVERSITY | $361,432 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this study is to develop and test the feasibility of using individually tailored theoretically-based intervention strategies to promote mammpgraphy screening among non-adherent Chinese-American women. | Health and Human Services, Department of / National Institutes of Health | 5/11/2009 |
| UNIVERSITY OF ILLINOIS | $393,169 | Grant | Trans-NIH Recovery Act Research Support: Median survival from a hepatocellular cancer (HCC) diagnosis is only 8 months; therefore, effective prevention strategies are a high priority. Due to the epidemic of hepatitis C in the 1960G??s-70G??s, incidence has increased; approximately 3.2 million pe | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $395,573 | Grant | Trans-NIH Recovery Act Research Support: Prostate cancer is the most commonly diagnosed noncutaneous cancer in United States men and the second leading cause of cancer death. It is estimated that 186,320 men will be diagnosed with prostate cancer in 2008 and 28,660 men will die of it. Prostate c | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $396,880 | Grant | Trans-NIH Recovery Act Research Support: With completion of the genome sequence and the estimated 20-25,000 genes comprising its entirety, it has become clear to investigators that the complexity of humans cannot be fully explained by so few genes. Alternative splicing of mRNA provides an intric | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK INC | $419,909 | Grant | Trans-NIH Recovery Act Research Support: Children with unfavorable histology Wilms tumor (WT) and metastatic disease continue to experience high mortality rates. These patients urgently require new therapies. We have recently reported Phase I data indicating excellent tolerance of the anti-vascu | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $527,204 | Grant | Trans-NIH Recovery Act Research Support: TodayG??s medical imaging methods have insufficient specificity for reliable differentiation between benign and malignant breast lesions in patients. Pathologic evaluation is currently the only way to obtain a definitive diagnosis. This research will use | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $381,140 | Grant | Trans-NIH Recovery Act Research Support: Many types of cancer exist in the body in environments that are highly acidic (low pH) compared with normal healthy tissue. This increase is acidity is believed to contribute to cancer progression and its resistance to therapy. For these reasons, we hyp | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| SCHEPENS EYE RESEARCH INSTITUTE, INC., THE | $529,375 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of the research is to test the hypothesis that fibroblast growth factor 15 (FGF15) is a key signal regulating the transition from neurogenesis to gliogenesis in the developing cortex and that drugs of abuse may alter FGF15 signaling to ca | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC. | $426,250 | Grant | Trans-NIH Recovery Act Research Support: The main goals of our parent grant (R01AA10788) are to test in alcohol dependent individuals (i) if chronic smoking influences brain injury, (ii) if chronic smoking effects ares functionally significant, and (iii) to what extent chronic smoking modulates | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF WASHINGTON | $425,458 | Grant | Trans-NIH Recovery Act Research Support: Addiction is a potent risk factor for suicide and suicidal behavior. Although suicide is 5 to more than 100 times more frequent among people with addiction disorders, and even higher among people in addiction treatment, no suicide prevention efforts have | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| THE VANDERBILT UNIVERSITY | $309,875 | Grant | Trans-NIH Recovery Act Research Support: A recent imaging study suggested that damage to the insular cortex (IC) results in cessation of smoking in chronic cigarette users. However, the regions of interest designated as the IC in this imaging study included not only the IC but also the claustru | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | $312,916 | Grant | Trans-NIH Recovery Act Research Support: All neurotransmitters require an efficient mechanism to terminate their action. Water-soluble neurotransmitters diffuse unassisted in the cytosol to their respective catabolic enzyme for breakdown, after being transported into cells. The endocannabinoids, | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| BRANDEIS UNIVERSITY | $315,917 | Grant | Trans-NIH Recovery Act Research Support: Synapses are specialized sites of cell-cell contact that mediate communication between neurons in the nervous system. Much remains to be discovered about the molecular mechanisms that underlie formation of these critical structures in the mammalian centra | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC. | $459,000 | Grant | Trans-NIH Recovery Act Research Support: Smoking tobacco remains the top preventable cause of disease and death in our society. Nicotine withdrawal is a major contributor to the persistent nature of tobacco use, as well as the frequent occurrence of relapse following attempts at smoking cessatio | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $184,280 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Cocaine addiction is a serious problem afflicting the United States, and treatment remains imperfect. Although the study of cocaine self-administration and reinstatement in rats has provided much knowledge of cocaine a | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $437,226 | Grant | Trans-NIH Recovery Act Research Support: Quantitative, acoustic models of segmental timing in spoken English, such as have been developed for text-to-speech synthesis (TTS), acknowledge that segment durations in connected speech reflect the combined influence of systematic factors as well as non | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF CHICAGO, THE | $429,000 | Grant | Trans-NIH Recovery Act Research Support: We have identified a novel peptide that acts as an effective therapeutic agent in mouse and hamster models of radiation-induced oral mucositis by targeting tight junctions (TJs) that connect adjacent epithelial cells, thereby protecting the mucosal barrie | Health and Human Services, Department of / National Institutes of Health | 4/29/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $424,875 | Grant | Trans-NIH Recovery Act Research Support: The morphology of a dental crown is controlled by a strictly regulated spatio-temporal expression of ameloblast specific genes encoding for enamel matrix proteins. Once ameloblasts enter the differentiation stage along the dentino-enamel junction (DEJ) an | Health and Human Services, Department of / National Institutes of Health | 5/01/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $402,719 | Grant | Trans-NIH Recovery Act Research Support: Removal of regional metastasis in head and neck squamous cell carcinoma (HNSCC) requires an extensive procedure with significant morbidity. Current imaging techniques cannot provide real-time information to clinicians or surgeons during diagnostic and the | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $266,249 | Grant | Trans-NIH Recovery Act Research Support: Most dialysis patients in the US are >65 years and are at increased cardiovascular risk. The prevalence of atrial fibrillation (AF) is higher in dialysis patients, but estimates vary widely (7%-27%). Further, controversy persists in defining its optimal m | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON | $1 | Grant | Trans-NIH Recovery Act Research Support: Award Description* DESCRIPTION (provided by applicant): Asymptomatic bacteriuria (ASB) is the isolation of a specified quantity of bacteria from a person without symptoms or signs referableto urinary infection. ASB is common in women and increases with ad | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON | $375,613 | Grant | Trans-NIH Recovery Act Research Support: Despite extensive research, the etiology of Crohn's inflammatory bowel disease remains unknown with possible suggestions attributed to genetic susceptibility, infectious agents, immune dysfunction, and various environmental agents. A number of clinical st | Health and Human Services, Department of / National Institutes of Health | 5/26/2009 |
| HEALTHPARTNERS RESEARCH FOUNDATION | $412,469 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Linking home environments and primary care: Obesity prevention for 2-4 year olds. Obesity prevention for at-risk preschool children is a public health priority. The pediatric primary care setting is a relatively untapp | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF CINCINNATI | $442,060 | Grant | Trans-NIH Recovery Act Research Support: Obesity and type 2 diabetes share several metabolic abnormalities, including an impaired ability of cells to sense increased nutrients flux. Since the brain plays a crucial role in regulating the homeostasis of fuel metabolism and body weight, the ultimat | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| NORTHSHORE UNIVERSITY HEALTHSYSTEM RESEARCH INSTITUTE | $431,038 | Grant | Trans-NIH Recovery Act Research Support: Over 7 million people in the U.S. suffer from chronic kidney disease and about half a million will await kidney replacement therapy. It is believed that the oxygen availability within the kidney may be an important determinant of the progression of disea | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $410,263 | Grant | Trans-NIH Recovery Act Research Support: The long term goal of our research is to investigate the role of smooth muscle myosin heavy chain (SMHC) isoforms in urinary bladder smooth muscle (SM) physiology and pathology. We have shown previously that alternative splicing of a single SMHC gene both | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| KAISER FOUNDATION HOSPITALS | $339,604 | Grant | Trans-NIH Recovery Act Research Support: Good glycemic control, lipid control, or blood pressure (BP) control can be achieved by adherence to recommended care, including medication, preventive care, and lifestyle modifications. Good physiologic control, in turn, attenuates risk of progression to | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $486,542 | Grant | Trans-NIH Recovery Act Research Support: The sterol response element binding protein (SREBP) transcription factors have been identified as key regulators of genes involved in both cholesterol and lipid homeostasis. Because of the prominence of aberrant cholesterol and lipid homeostasis in the me | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| RUSH UNIVERSITY MEDICAL CENTER | $464,574 | Grant | Trans-NIH Recovery Act Research Support: Preliminary evidence suggests that exposure to air pollution may be related to cognitive decline, particularly among older women, and our project evaluates this relation in a large population of older women. Since exposure to air pollution is a potential | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $421,464 | Grant | Trans-NIH Recovery Act Research Support: Lung adenocarcinoma is among the deadliest cancer types world-wide. Solid tumors such as these almost universally acquire adaptive changes to survive hypoxic energy stress. This confers an increase in aggressiveness and resistance to chemotherapy and radi | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $433,002 | Grant | Trans-NIH Recovery Act Research Support: Recent research suggests that obesity and diet induce inflammation in adipose tissue, which may enhance the development of type 2 diabetes mellitus (T2DM) and insulin resistance (IR). Epidemiological studies have demonstrated that exposure to air pollutio | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| PURDUE UNIVERSITY | $752,271 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION: Osteoporosis is a serious health concern of the elderly that is expected to become more prevalent as the US population ages. Like many complex physiological systems, bone biology is dependent on both genetic factors and environmental factors | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| SAINT LOUIS UNIVERSITY | $387,127 | Grant | Trans-NIH Recovery Act Research Support: Phototransduction in retinal rods relies on signaling mediated by the heterotrimeric G-protein transducin. We investigate the involvement of the transducin beta-gamma complex in visual signal propagation and amplification, as well as in the morphogenesis | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $431,018 | Grant | Trans-NIH Recovery Act Research Support: Cited2 (CBP/p300-interacting transactivators with glutamic acid (E) and aspartic acid (D)-rich tail 2) is a founding member of a new family of transcriptional modulators. My laboratory cloned Cited2 and showed that Cited2 is induced by many biological sti | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| MAYO CLINIC | $415,525 | Grant | Trans-NIH Recovery Act Research Support: Corneal endothelial cell dysfunction causes decreased vision and can only be treated by corneal transplantation to replace human corneal endothelial cells (HCECs), which do not proliferate in vivo. Over 15,000 corneal transplants are performed every year | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| UNIVERSITY OF UTAH, THE | $413,771 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The hyaloid vascular system (HVS) is a transient vascular network that nourishes the immature lens and retina before formation of the retinal vasculature. Defects in HVS development can lead to serious congenital eye d | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| WASHINGTON UNIVERSITY, THE | $416,974 | Grant | Trans-NIH Recovery Act Research Support: Cone photoreceptors function under daylight conditions and are essential for color perception and vision with high temporal and spatial resolution. A remarkable feature of cones is their ability to remain functional in bright light which requires powerful | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| SOUTH CAROLINA RESEARCH FOUNDATION | $382,223 | Grant | Trans-NIH Recovery Act Research Support: Causal Estimates of Neighborhood Poverty on Health & Mortality Project Summary Abstract The disparities in the distribution of goods and services, and hazards and opportunities across space are increasing, underscoring the growing connection between place | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF NEVADA, RENO | $351,250 | Grant | Trans-NIH Recovery Act Research Support: In most species, including humans, plasma levels of 17+?-estradiol and progesterone increase during pregnancy. The elevation of female hormones that accompanies the late stages of pregnancy has been linked to electrical remodeling of myometrial smooth mus | Health and Human Services, Department of / National Institutes of Health | 5/11/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $440,716 | Grant | Trans-NIH Recovery Act Research Support: Mammalian ovaries consist of follicles as basic functional units. The total number of ovarian follicles is determined early in life, and the depletion of this pool leads to reproductive aging. During initial recruitment of follicles, unknown intraovarian | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| BAYLOR COLLEGE OF MEDICINE | $415,153 | Grant | Trans-NIH Recovery Act Research Support: More than 50% of male cancer patients subjected to cisplatin-based chemotherapy will suffer from long-term infertility. This is a significant concern because many of these patients are young men who survive their cancer and would hope to later reproduce. | Health and Human Services, Department of / National Institutes of Health | 9/02/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $402,221 | Grant | Trans-NIH Recovery Act Research Support: Preterm delivery, an increasingly frequent occurrence in the United States, is associated with significant family burden and an estimated societal cost of at least $26 billion per year. In the U.S., the preterm birth rate is 12-13% as compared to 5-9% in | Health and Human Services, Department of / National Institutes of Health | 8/12/2009 |
| MAINE MEDICAL CENTER | $413,875 | Grant | Trans-NIH Recovery Act Research Support: Human embryonic stem (ES) cells have great therapeutic potential for various diseases, and generation of these cells has raised many ethical concerns. Therefore, generation of patient-specific (or isogenic) pluripotent stem cells by somatic cells reprogra | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $535,645 | Grant | Trans-NIH Recovery Act Research Support: 5R21HD065269-02 (MPI) Gene Expression and Immune Cell Function in Mothers of Children with Autism. Whole genome expression will be assessed in blood of mothers and compared to autoantibodies in the blood of the mothers. Both of these will be compared | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $999,936 | Grant | Trans-NIH Recovery Act Research Support: Genetic/Epigenetic Markers, Social Contexts, Lifecourse & Risky Health Behaviors This project addresses broad challenge area (01) Behavior, Behavioral Change, and Prevention and two highly related specific Challenge Topics: (A) 01-OD(OBSSR)-102* Method | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $989,491 | Grant | Trans-NIH Recovery Act Research Support: In response to Challenge Area 04: Clinical Research and specific Challenge Topic 04-DC-101: Prevention of Otitis Media, we propose a clinical trial of a preparation of viscous xylitol with a mucosal adherence agent for the prevention of acute otitis media | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $432,178 | Grant | Trans-NIH Recovery Act Research Support: Atherosclerosis is a systemic disease; however, its manifestations tend to be focal and eccentric. Hemodynamics, specifically, fluid shear stress, is intimately involved in vascular oxidative stress. Oxidative stress induces molecular signaling regulates | Health and Human Services, Department of / National Institutes of Health | 5/28/2009 |
| UNIVERSITY OF TEXAS AT EL PASO | $420,082 | Grant | Trans-NIH Recovery Act Research Support: Low health literacy is a factor contributing to poorer health status and higher mortality and morbidity among Hispanics. Studies have systematically found low levels of health literacy in this population group. The literature has discussed extensively the | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF OKLAHOMA | $402,875 | Grant | Trans-NIH Recovery Act Research Support: Cardiovascular disease (CVD) and depression are chronic diseases with complex genetic etiologies. Epidemiological studies have documented the co-occurrence of depression and CVD. However, the potential mechanisms linking depression to CVD remain unclear. | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| NEW YORK UNIVERSITY (INC) | $412,529 | Grant | Trans-NIH Recovery Act Research Support: 1R21HL092370-01A2 MUSCULARIZATION OF PULMONARY ARTERIES INDUCED BY AN ADAPTIVE IMMUNE RESPONSE. Muscularization of pulmonary arteries induced by an adaptive immune response Abstract Pulmonary arterial hypertension (PAH) is a devastating condition because | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| INSTITUTE FOR SYSTEMS BIOLOGY | $423,995 | Grant | Trans-NIH Recovery Act Research Support: According to the National Center for Environmental Health one in four Americans suffers from asthma or allergies with the direct costs of treating asthma totaling more than $10 billion every year. In addition, Asthma rates in children under the age of fi | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| NANOVA INC | $509,669 | Grant | Trans-NIH Recovery Act Research Support: Project Title: Calcium Phosphate Bone Cement Nanocomposites Project Description: Calcium phosphate cements (CPCs) are used in orthopedic surgery as bone filler and have been proved with very good biocompatibility. However, the inadequate mechanical prope | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| NEOSTEM, INC. | $108,746 | Grant | Trans-NIH Recovery Act Research Support: NeoStem will conduct research on stem cells and explore their enormous promise to produce breakthrough therapies and cures. The study will investigate the effect of a marrow population of mesenchymal cells (MSCs)that are very small and have embryonic-lik | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |