Listing all stimulus spending by amount, in descending order. Return to National Institutes of Health page
Amount refers to both the amount of stimulus funding going toward the project and the face value of the loan.
| Recipient | Amount | Type | Description | Federal Dept./Agency | Date |
|---|---|---|---|---|---|
| RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | $61,445 | Grant | Trans-NIH Recovery Act Research Support: A prevalent form of relapse in addiction is caused by exposure to cues or contexts formerly paired with drug delivery. The ability of drug-paired conditioned stimuli (CSs) to increase incentive motivation, or craving, indicates that the rewarding properti | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| RAND CORPORATION, THE | $179,695 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Little attention has focused on barriers to coverage among the privately insured children, although, a large portion of the American children are covered under private insurance. Especially in an era of deteriorating p | Health and Human Services, Department of / National Institutes of Health | 5/28/2009 |
| THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | $151,971 | Grant | Trans-NIH Recovery Act Research Support: The canonical Wnt/?-catenin signaling pathway regulates virtually all aspects of embryonic development. More recently, dysregulation of this signaling cascade has been linked to a range of human diseases, most notably cancer. Activation of this pathway re | Health and Human Services, Department of / National Institutes of Health | 5/04/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $176,840 | Grant | Trans-NIH Recovery Act Research Support: Unwanted childbearing has been hypothesized to have significant detrimental health, social and economic consequences for children and parents, and represents a primary justification for investment in family planning programs. While the literature supporti | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| RESEARCH TRIANGLE INSTITUTE | $180,652 | Grant | Trans-NIH Recovery Act Research Support: This study will be the first we are aware of to estimate the influence of peers on adolescent weight-related behavior that also controls for alternative, co-occurring reasons. Study results will be used to develop and improve public health policies need | Health and Human Services, Department of / National Institutes of Health | 9/08/2009 |
| NORTHWESTERN UNIVERSITY | $152,113 | Grant | Trans-NIH Recovery Act Research Support: Patients with diabetes insipidus (DI) present with persistent thirst, polydipsia, and hypotonic polyuria. The disorder is caused by several distinct etiologies and an appropriate diagnostic work-up is essential for the distinction of the various forms tha | Health and Human Services, Department of / National Institutes of Health | 8/12/2009 |
| OKLAHOMA STATE UNIVERSITY | $147,700 | Grant | Trans-NIH Recovery Act Research Support: Idiopathic Pulmonary Fibrosis (IPF) is a chronic interstitial lung diseases characterized by pulmonary inflammation and fibrosis. The pathogenesis of IPF involves multiple cell-cell interactions, cross-talk of multiple signal transduction pathways and gen | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $164,000 | Grant | Trans-NIH Recovery Act Research Support: Title: Mechanisms of VCP/p97 and Proteasomal Pathway in COPD Pathogenesis. Award Description: Cigarette smoking induces oxidative stress and unfolded protein response (UPR), and is the major risk factor for emphysema and COPD (chronic obstructive pulmonar | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $164,000 | Grant | Trans-NIH Recovery Act Research Support: Title of the project is Targeting AP-1 proteins In COPD. Chronic obstructive pulmonary disease (COPD), which consists of emphysema and chronic bronchitis, is a major public health concern with no effective treatment. Various cellular processes that mainta | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $153,334 | Grant | Trans-NIH Recovery Act Research Support: Bacterial infection of lung airways underlies some of the main complications of COPD, which impact significantly in disease progression and outcome. Acute exacerbations (AE) represent one of the major contributing factors of morbidity, clinical deteriorat | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON | $150,000 | Grant | Trans-NIH Recovery Act Research Support: The primary goal of this project is to reverse-engineer the interplay of gene variation (in candidate genes influencing renal tubular sodium transport and involved in renin-angiotensin-aldosterone system) and other variables contributing to the interindiv | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| PRESIDENT AND FELLOWS OF MIDDLEBURY COLLEGE | $199,428 | Grant | Trans-NIH Recovery Act Research Support: Successful prevention and treatment of alcohol use disorders depend on identifying factors that lead to excessive consumption and addictive behaviors. Yet, to date, the factors that lead from social drinking to alcohol abuse still are not clearly defined. | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| WESTERN WASHINGTON UNIVERSITY | $159,833 | Grant | Trans-NIH Recovery Act Research Support: The experiments described in the proposal will establish the fruit fly Drosophila as a model to study human Lamin A processing. It is possible to incorporate human genes into the fly genome (so-called transgenic flies). When transgenically expressed in | Health and Human Services, Department of / National Institutes of Health | 8/18/2009 |
| CORPORATION OF HAVERFORD COLLEGE, THE | $202,335 | Grant | Trans-NIH Recovery Act Research Support: New experiments are needed to view and to understand the structure of the most dynamic and disordered proteins. Vibrational spectra of proteins can provide this specific information with very fast instrinsic time resolution. A strategy is proposed here | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| VASSAR COLLEGE | $183,773 | Grant | Trans-NIH Recovery Act Research Support: The main objective of the proposed project is to determine the role of the energy balance hormone leptin on early developmental processes, including limb bud growth and differentiation, in the South African clawed frog (Xenopus laevis). Because leptin (p | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| BOISE STATE UNIVERSITY | $211,500 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this study is to investigate the molecular and cellular mechanisms that regulate vertebrate development using a zebrafish model system. Collagen type XI plays an essential role in skeletal development, as demonstrated by Stickler syndrome a | Health and Human Services, Department of / National Institutes of Health | 8/12/2009 |
| UNIVERSITY OF FLORIDA | $402,875 | Grant | Trans-NIH Recovery Act Research Support: Fetal alcohol syndrome (FAS) is a significant cause of mental retardation and birth defects worldwide. However, the mechanisms by which ethanol causes the developmental anomalies and neurotoxicity characteristic of FAS are poorly understood. We hypothesiz | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $443,524 | Grant | Trans-NIH Recovery Act Research Support: We have convincing preliminary data that has identified a unique subset of spinal nociceptive nerves that receives innervation from both the stomach and the pancreas, suggesting a novel neural cross-talk mechanism between the two organs that involves TRPV | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER | $395,331 | Grant | Trans-NIH Recovery Act Research Support: One of the primary causes of birth defect in the United States is maternal alcohol consumption. This may be due to the ability of alcohol to increase the normal apoptotic death of neurons in the developing brain. The research in this proposal will address | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $405,218 | Grant | Trans-NIH Recovery Act Research Support: Ethanol and HBV Infection on HCC Development in a Novel Humanized Mouse Model Hepatocellular carcinoma (HCC) is the most common primary cancer of the liver. Chronic infection caused by hepatitis B virus (HBV) plays an important role in the development and | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| CORNELL UNIVERSITY, INC | $358,545 | Grant | Trans-NIH Recovery Act Research Support: This Award aims to investigate how aging is impacted by certain special features of the genome that are stably inherited through multiple rounds of cell division, but do not involve changes in the DNA sequence. These epigenetic features often involve spe | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO | $357,734 | Grant | Trans-NIH Recovery Act Research Support: The incidence of cancer increases with age, suggesting that multiple events (DNA mutations) must take place for malignant transformation to occur. It is known that natural defense mechanisms serve to protect against accumulation of DNA mutations and to di | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| UNIVERSITY OF PITTSBURGH THE | $341,954 | Grant | Trans-NIH Recovery Act Research Support: High throughput assay development for Huntington's Disease - In this application we propose to develop new high throughput screening assays for identifying aggregation inhibitors in large libraries of small molecules. The premise of this proposal is that | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) | $429,000 | Grant | Trans-NIH Recovery Act Research Support: The mechanism of HCV replication is not clearly understood. Moreover, the cellular or viral components of the HCV replication complex have not been well defined. This project is aimed at isolating the HCV replication complex and identifying the cellular a | Health and Human Services, Department of / National Institutes of Health | 5/06/2009 |
| THE GEORGE WASHINGTON UNIVERSITY | $250,556 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of our research is to understand how the chromatin environment, Tat, and chromatin remodelers/modifiers cooperate to influence HIV-1 transcription. Tat, in its unmodified form, associates with the histone acetyltransfersase p300/CBP. Ho | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $371,250 | Grant | Trans-NIH Recovery Act Research Support: This project is being supported with funds from the American Recovery and Reinvestment Act, which may involve a reduction in the research aims and scope. If necessary, a revised abstract will be posted soon and this notice removed. DESCRIPTION (provided | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $233,625 | Grant | Trans-NIH Recovery Act Research Support: The Alphavirus genus, family Togaviridae, includes viruses that are significant human pathogens. Chikungunya virus (CHIKV) is an arbovirus, transmitted between human and non-human primates by the bite of an infected mosquito vector. CHIKV periodically cau | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA AT RIVERSIDE | $474,364 | Grant | Trans-NIH Recovery Act Research Support: Hepatitis B Virus (HBV) infects more than 2 billion people alive today and is responsible for over 1 million deaths caused by acute and chronic hepatitis and hepatocellular carcinoma every year. Although remarkable progress has been made in understanding | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF MONTANA SYSTEM | $389,126 | Grant | Trans-NIH Recovery Act Research Support: Coxiella burnetii is an extremely infectious, obligate intracellular bacterium that causes Q fever, and is a Select B Agent. Q fever manifests as acute (pneumonitis, malaise) or chronic (hepatitis, endocarditis) disease. Longterm goals are to identify bac | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $99,999 | Grant | Trans-NIH Recovery Act Research Support: Acquisition of an isothermal titration calorimeter to accelerate the tempo of our scientific research to understand neurodegenerative disease caused by human prions, and to find therapies and cures for these fatal diseases. | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $385,000 | Grant | Trans-NIH Recovery Act Research Support: Allergic diseases, such as asthma, are promoted by abnormal differentiation of T helper type 2 (Th2) cells. A recently described T cell subset (termed Th17 cells) has been found to promote inflammation and autoimmune disease, in large part due to their se | Health and Human Services, Department of / National Institutes of Health | 5/06/2009 |
| UNIVERSITY OF NEW MEXICO | $412,500 | Grant | Trans-NIH Recovery Act Research Support: Enterotoxigenic Escherichia coli (ETEC) are among the primary causes of infantile and traveler's diarrhea. Despite the number and severity of ETEC infections worldwide, at present no licensed vaccine is available for at-risk individuals. We have developed | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $433,125 | Grant | Trans-NIH Recovery Act Research Support: Hepatitis is a pathological syndrome of liver injury that has several causes and is characterized by varying degrees of liver injury. Chronic hepatitis C and hepatitis B virus infections in humans result in liver damage, inflammation, and secondary develo | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF IOWA, THE | $412,432 | Grant | Trans-NIH Recovery Act Research Support: The Leishmania spp. protozoa have a profound effect on the host cell that they invade. These parasites reside intracellularly usually in macrophages, a cell type with the capacity to kill intracellular microbes. Rather than succumb to microbicidal mechani | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $522,226 | Grant | Trans-NIH Recovery Act Research Support: We recently developed a unique reagent that combines the functions of an anthrax antitoxin and vaccine in a single compound. This reagent is based on multivalent display of the anthrax toxin receptor, ANTXR2, on the surface of an icosahedral insect virus. | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF NEW MEXICO | $412,500 | Grant | Trans-NIH Recovery Act Research Support: The progressive lung damage in cystic fibrosis (CF) arises from characteristic bacterial colonization with Pseudomonas aeruginosa being central After initial infection then colonization with wild-type strains, conversion of P. aeruginosa to the mucoid phe | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF WASHINGTON | $332,519 | Grant | Trans-NIH Recovery Act Research Support: HSV-1 is a significant human pathogen. This virus sets up lifelong latent infections in the trigeminal ganglia. Dutch collaborators have obtained appropriate clearances and obtained trigeminal ganglia tissues at autopsies. We have confirmed that these t | Health and Human Services, Department of / National Institutes of Health | 7/23/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $495,255 | Grant | Trans-NIH Recovery Act Research Support: The development of the arylomycin class of natural product antibiotics, which kill bacteria via the novel mechanism of inhibiting type I bacterial signal peptidases and protein transport, has been abandoned because these compounds are not sufficiently pot | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY | $375,604 | Grant | Trans-NIH Recovery Act Research Support: The threat of an intentional release of bacterial select agents prompts the need for their rapid, culture-free diagnosis that can be conducted in the field or in laboratories with only basic diagnostic capabilities. Optical fiber biosensors are attractive | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $426,515 | Grant | Trans-NIH Recovery Act Research Support: Gene therapy is developing into a viable alternative for the treatment of many diseasesincluding immune system disorders, certain cancers, and even HIV infection. In genetherapy, a gene of interest is delivered to a target cell, which in some cases is aqu | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| LEHIGH UNIVERSITY | $410,431 | Grant | Trans-NIH Recovery Act Research Support: HIV infection affects more than 33 million people globally. Measurement of the level of circulating virus in the blood plasma, or G?viral load,G? is a critical parameter used to monitor disease progression and make treatment decisions. However, it is wide | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| MICHIGAN STATE UNIVERSITY | $360,025 | Grant | Trans-NIH Recovery Act Research Support: The food borne pathogen Campylobacter jejuni (CJ) causes between 2.5 and 3 million human disease cases and approximately 100 deaths annually at an estimated cost of between 1.6 and 6.2 billion dollars. Poultry is the major reservoir for human disease caus | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| UNIVERSITY OF ROCHESTER | $422,239 | Grant | Trans-NIH Recovery Act Research Support: The resurgence of tuberculosis and the spread of antibiotic resistant strains of the causative agent, Mycobacterium tuberculosis, present a significant public health challenge. Tuberculosis kills nearly 2 million people each year and estimates put the wor | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $375,000 | Grant | Trans-NIH Recovery Act Research Support: The Role of DNA Repair in Retroviral Infection The goal of this proposal is to examine two well-defined host DNA repair pathways that act as positive and negative regulators of retroviral infection. Our previous studies have identified the Nucleotide Exci | Health and Human Services, Department of / National Institutes of Health | 5/19/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $408,375 | Grant | Trans-NIH Recovery Act Research Support: This project is being supported with funds from the American Recovery and Reinvestment Act, which may involve a reduction in the research aims and scope. If necessary, a revised abstract will be posted soon and this notice removed. DESCRIPTION (provided | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $408,238 | Grant | Trans-NIH Recovery Act Research Support: This research program targets at the search for the true endogenous ligands for the iNKT cells development. Conventional CD4+ and CD8+ T cells of the immune system recognize specific peptide antigens bound to major histocompatibility complex (MHC) class I | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $415,229 | Grant | Trans-NIH Recovery Act Research Support: Excessive inflammation at mucosal surfaces in the airway disrupts normal physiology and can lead to acute lung injury (ALI) and its most severe form the acute respiratory distress syndrome (ARDS). The pulmonary inflammatory response during these clinical | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $423,500 | Grant | Trans-NIH Recovery Act Research Support: The epithelium separates the vast array of luminal antigens from the underlying gastrointestinal tissue and in this position, it serves as the first site to encounter many pathogens. Epithelial cells emerge from stem cells from the deeper layers of the gl | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| THE INSTITUTE FOR CANCER RESEARCH | $503,770 | Grant | Trans-NIH Recovery Act Research Support: Title: Characterization of Type-2 Cytokine-Producing NK Cells Abstract: Allergic immune responses are biased toward the production of type-2 cytokines. We have identified new surface markers of a small subset of human natural killer (NK) cells that prod | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $412,500 | Grant | Trans-NIH Recovery Act Research Support: The innate immune system is designed to guard against potentially dangerous infections, but recent studies also show that our immune system can become activated by 'self-antigens' which are released during severe acute illnesses, such as trauma, pancreati | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $327,000 | Grant | Trans-NIH Recovery Act Research Support: Project Title: Understanding the malaria-poverty vicious circle. Our goals are to develop analytical and empirical assessments of the bi-directional malaria-poverty causality. We will propose a conceptual framework of factors that impact the links between | Health and Human Services, Department of / National Institutes of Health | 7/23/2009 |
| THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | $460,294 | Grant | Trans-NIH Recovery Act Research Support: Positron emission tomography (PET) radioisotopes, such as carbon-11 (11C) and fluorine-18 (18F), will be incorporated into current antibiotics, such as the tuberculosis drugs isoniazid and rifampicin, in order to directly identify the protein target(s) fo | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF UTAH, THE | $398,323 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Wear of bearing surfaces is possibly the greatest limitation to the longevity of hip joint replacement components. The bearing stresses from normal joint loading may be well studied; however, load cases involving edge | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $474,223 | Grant | Trans-NIH Recovery Act Research Support: Breast milk contains maternal antibodies (MatAbs) that promote infant health and moderate diarrhea, and soluble immunomediators (TGF2, IL4, sCD14, etc) whose role is largely unexplored. Rotavirus (RV) is a leading cause of diarrhea in infants worldwide. N | Health and Human Services, Department of / National Institutes of Health | 4/27/2009 |
| DUKE UNIVERSITY | $310,969 | Grant | Trans-NIH Recovery Act Research Support: Cigarette smoking is highly prevalent among persons with posttraumatic stress disorder (PTSD) and individuals with PTSD have decreased odds of successfully quitting smoking. There is a need to develop more effective interventions and to evaluate factors a | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $419,201 | Grant | Trans-NIH Recovery Act Research Support: On April 12, 2007, the American College of Surgeons' (ACoS) Commission on Cancer in conjunction with the National Quality Forum released quality measures for the treatment of breast cancer.5 These evidence-based measures of adjuvant treatments proven to i | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| THOMAS JEFFERSON UNIVERSITY | $373,890 | Grant | Trans-NIH Recovery Act Research Support: We have recently imported into our laboratory the Sleeping Beauty transposon system. The sleeping beauty transposon is a transposable mobile element that requires two unlinked genetic loci and has been shown to induce tumorigenesis in the mouse. Making us | Health and Human Services, Department of / National Institutes of Health | 5/13/2009 |
| RAND CORPORATION, THE | $420,678 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): There is ample evidence to suggest that a relationship exists between exposure to cigarette advertising and smoking in children and adolescents under the age of 18. Studies documenting this relationship have been extre | Health and Human Services, Department of / National Institutes of Health | 5/13/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $400,875 | Grant | Trans-NIH Recovery Act Research Support: Bladder cancer is one of the commonly diagnosed malignancies in both males and females. One approach to control bladder cancer is growth inhibition wherein the disease is prevented, slowed, or reversed significantly by the administration of naturally occu | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO | $654,821 | Grant | Trans-NIH Recovery Act Research Support: Despite the development of several targeted agents, patients with advanced cancer that fail conventional therapies have an extremely poor prognosis. Identification of the mechanisms that contribute to therapeutic resistance is essential to improve clinica | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF PITTSBURGH THE | $366,632 | Grant | Trans-NIH Recovery Act Research Support: This R21 award supports a 2 year project: Augmentation of NK cell-mediated anti-cancer activity by dietary BITC We have found that dietary benzyl-isothiocyanate (BITC) is able to augment host NK cell function. In this project, we will investigate the i | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $410,190 | Grant | Trans-NIH Recovery Act Research Support: Prostate cancer is the third leading cause of cancer death of males in the United States. The common treatments for prostate cancer, hormone ablation and endocrine therapy, lead to temporary palliation. Identification of other novel molecular targets inde | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| SALK INSTITUTE FOR BLOGICAL STUDIES | $520,850 | Grant | Trans-NIH Recovery Act Research Support: Drug addiction is a major health problem in the U.S. Although there have been significant advances in our understanding the neurochemical changes in addiction, there is a need to develop new approaches and to identify novel targets for elucidating the mol | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $393,684 | Grant | Trans-NIH Recovery Act Research Support: Responsible decision-making is a cornerstone of prevention programs. However, attention has focused primarily on an individual's responsibility for his/her own behavior. Our project frames the avoidance of ATOD as a social responsibility that friends shou | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $445,750 | Grant | Trans-NIH Recovery Act Research Support: This planning grant will serve to plan a randomized control trial among five research centers to test whether adolescent maxillary protraction can be a non-surgical alternative to orthognathic surgery as a treatment for a skeletal underbite in the cleft l | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $414,486 | Grant | Trans-NIH Recovery Act Research Support: The incidence of kidney disease is ever increasing. None of the current therapies can improve regeneration of the injured kidneys. With the identification of stem cells in adult organs, and their potential role in tissue regeneration, cellular source of r | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $404,495 | Grant | Trans-NIH Recovery Act Research Support: This project is being supported with funds from the American Recovery and Reinvestment Act, which may involve a reduction in the research aims and scope. If necessary, a revised abstract will be posted soon and this notice removed. DESCRIPTION (provided | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $420,750 | Grant | Trans-NIH Recovery Act Research Support: Self-renewing epithelial tissues in skin, cornea, intestine and prostate have been shown to contain stem cells that provide the tissues regenerative potential. Surprisingly, no such stem cell has yet been definitively identified in the bladder. The goal o | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $419,216 | Grant | Trans-NIH Recovery Act Research Support: The rising prevalence of diabetes parallels the rise in obesity in the U.S. The prevention of weight gain and promotion of weight loss using novel approaches among people with diabetes is needed to reduce the morbidity and mortality associated with obesit | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $446,875 | Grant | Trans-NIH Recovery Act Research Support: Arteriovenous (AV) fistulas provide the optimal vascular access for hemodialysis in patients with end stage renal disease (ESRD), yet nearly 50% of fistulas fail soon after their surgical construction due, in part, to intimal hyperplasia of venous smooth | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $878,148 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Methylmercury (MeHg) is a ubiquitous environmental pollutant. The neurotoxicity of MeHg and the high susceptibility of the developing brain are well established both in humans and experimental animals. Prenatally expos | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| THE VANDERBILT UNIVERSITY | $414,901 | Grant | Trans-NIH Recovery Act Research Support: Visual signal transduction depends upon the GPCR rhodopsin and heterotrimeric guanine nucleotide binding proteins (G-proteins; G? and G??). Structural characterization of opsin, rhodopsin, and G-proteins in multiple states has provided exceptional insight | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERISTY OF MISSISSIPPI MEDICAL CENTER | $407,000 | Grant | Trans-NIH Recovery Act Research Support: Major depression and alcoholism feature lower-than-normal densities of neurons and glial cells in the prefrontal cortex (PFC) brain region heavily involved in addictive and affective disorders. In establishing the pathophysilology of MDD and alcoholism, | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE | $396,000 | Grant | Trans-NIH Recovery Act Research Support: Using a Community Based Participatory Research Approach to Examine Family Support The long-range objectives of this project are to improve family functioning and reduce disparitites in mental health services and outcomes through the development of a sust | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| THE CHILDRENS HOSPITAL LOS ANGELES | $2,862,111 | Grant | Trans-NIH Recovery Act Research Support: Diagnostic gene expression profiles were first identified ten years ago to identify subsets of childhood leukemia. Since then, untold thousands of studies (2909 listed in PubMed using G??cancer diagnosis microarraysG??) have been published purporting to b | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $1,454,073 | Grant | Trans-NIH Recovery Act Research Support: Symptom Mgmt. Faculty Scholars Porgram is developing 6 new Assistant Professors who are receiving focused training from senior faculty, to become skilled, independant researchers with grantsmanship skills, who can disseminate findings in journals, and bec | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| NOVA SOUTHEASTERN UNIVERSITY, INC. | $344,592 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Health literacy is a critically important problem in improving the health outcomes in patients with HIV infection. Patient behaviors essential to the successful treatment of HIV infection, such as high levels of medica | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $451,000 | Grant | Trans-NIH Recovery Act Research Support: We received 2 years of funding from ARRA funds, with the first year allocation of $ 205,000, for an application to the NIMH originally submitted as an R21, entitled 'Neurons from pluripotent stem cells derived from schizophrenia patient fibroblasts'.-? Th | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY, THE | $830,664 | Grant | Trans-NIH Recovery Act Research Support: A Community Participator Approach to Improving Health in a Hispanic Population Charlotte, NC is home to one of the nation's fastest growing Hispanic communities. As in other parts of the U.S., Hispanics here face significant health disparities in part be | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, THE | $415,000 | Grant | Trans-NIH Recovery Act Research Support: Mature B cells become antibody secreting plasma cells through a complex process that begins in the germinal center and involves alterations in multiple transcription factors. Work from this laboratory has identified a new player in B cell activation and d | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| NEW YORK UNIVERSITY (INC) | $845,000 | Grant | Trans-NIH Recovery Act Research Support: The RO1 AI 083655 and one year R56 Bridge studies will focus on analysis of Nasal Associated Lymphoid Tissue (NALT) and particulate antigens as needle-free vaccines and the role of inflammasome vs TLR signaling in immune responses to nanoparticle malaria | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $508,500 | Grant | Trans-NIH Recovery Act Research Support: The increasing prevalence of diabetes and obesity constitutes one of the greatest challenges to public health in the U.S. and in the world. We have shown that a single gene product, glucokinase, expressed in a relatively small number of cells in the brain | Health and Human Services, Department of / National Institutes of Health | 6/11/2009 |
| UNIVERSITY OF OKLAHOMA | $289,745 | Grant | Trans-NIH Recovery Act Research Support: GLUT4 is the isoform principally responsible for insulin-mediated glucose uptake in mammalian tissues. Glucose homeostasis is sensitive to changes in GLUT4 levels. Modulation of GLUT4 levels is therefore an attractive molecular target for therapeutic in | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| UNIVERISTY OF MISSISSIPPI MEDICAL CENTER | $148,000 | Grant | Trans-NIH Recovery Act Research Support: Chronic oxidative stress in diabetes, resulting from a combination of chronic inflammation and mitochondrial dysfunction, is a major contributing factor in the debilitating pathologies associated with this disease. The applicant's lab has recently discov | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $150,000 | Grant | Trans-NIH Recovery Act Research Support: Mild vitamin A deficiency is present in 5-7 million pregnant women worldwide, a condition that in animal models can result in sup-optimal organogenesis. Understanding the role of vitamin A during gestation is thus of great importance. Our studies of uroge | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $714,008 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (01) Behavior, Behavioral Change, and Prevention and specific Challenge Topic 01-AA-103* Capturing Social Network Information for Groups at High Risk for Negative Health Behaviors Research on social network | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| WAKE FOREST UNIVERSITY | $814,020 | Grant | Trans-NIH Recovery Act Research Support: This application entitled, 'Discovering Pathways of Functional Decline: A GWAS Approach' addresses the challenge area (08): Genomics and the specific challenge topic, 08-AG-101: Genetic factors affecting rates of change in disease risk factors with age. T | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| HEBREW HOME FOR AGED DISABLED | $831,981 | Grant | Trans-NIH Recovery Act Research Support: The overall goal is to improve the use of medications for older people with multiple medical disorders. Our first step will be to identify the prevalence, type and severity of prescribing problems in older people with defined patterns of multiple co-morbi | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF WASHINGTON | $994,622 | Grant | Trans-NIH Recovery Act Research Support: The persistence of virus reservoirs, with the capacity to fuel virus rebound, is the major obstacle to eliminating HIV infection. Identifying reservoirs of HIV-1 and sanctuaries where HIV-1 replication is not completely suppressed by antiretroviral (ARV) | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $676,326 | Grant | Trans-NIH Recovery Act Research Support: This project seeks to understand the basis of keloid formation, a form of disordered wound healing. In keloids, low oxygen tension and collagen deposition are both present, and we will investigate how low oxygen tension directly influences the biosynthes | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| SOUTHERN ILLINOIS UNIVERSITY | $974,024 | Grant | Trans-NIH Recovery Act Research Support: One third of Americans suffer from some form of chronic pain, (30% being resistant to analgesic therapy), making it a significant health problem with serious economic impact (estimated cost of approximately $100 billion annually).1 Chronic pain associated | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF IOWA, THE | $366,686 | Grant | Trans-NIH Recovery Act Research Support: This proposal addresses the broad subject area, Biomarker Discovery and Validation and the specific challenge topic, Biomarkers of Persistent Damage After Acute Joint Injury (03-AR-101). Our proposal entitled 'Biomarkers of the Risk for Post-Traumatic Ost | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $999,996 | Grant | Trans-NIH Recovery Act Research Support: This application addresses the broad Challenge area (06) Enabling Technologies, and the specific Challenge Topic, 06 EB 109: Model Driven Biomedical Technology Development. The objective of this proposal is to develop an image based disc model that incor | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: The overall purpose of this project is to identify defined techniques that facilitate the efficient generation of physiologically relevant neurons and myelinating Schwann cells from human skin precursor (SKP) cells. High throughput, cell based screens of | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF ARIZONA | $984,917 | Grant | Trans-NIH Recovery Act Research Support: The focus of this proposal is to create a model project to establish the protocols, based on previously developed methods, by which clinical research from existing data (perhaps modestly supplemented with new data acquisition) can be envisioned, designed, | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF WASHINGTON | $998,713 | Grant | Trans-NIH Recovery Act Research Support: Prostate cancer metastasizes to the bone in approximately 90% of patients with advanced disease and dissemination of tumor cells to the bone can lead to replacement of bone marrow, spinal cord compression, fracture, severe bone pain, cachexia and death. T | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $996,333 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (01) Behavior, Behavioral Change, and Prevention and specific Challenge Topic 01-CA-102, The Role of Nutrition in Cancer Biology. Our long term goals are to characterize the role of genomic stability in die | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| FOX CHASE CANCER CENTER | $981,011 | Grant | Trans-NIH Recovery Act Research Support: This application addresses Challenge Area (06): Enabling Technologies, and specific Challenge Topic, 06-OD (OBSSR)-101*, Using new technologies to improve or measure adherence, and is entitled G?Preventing postpartum smoking relapse: A C-SHIP based Text M | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $982,256 | Grant | Trans-NIH Recovery Act Research Support: Abstract The effectiveness of anticancer treatment can be compromised by structural or physiological barriers. This is particularly true for the treatment of intracranial malignancies. The grim prognosis associated with these tumors is due in part to t | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| DUKE UNIVERSITY | $998,459 | Grant | Trans-NIH Recovery Act Research Support: 'This application addresses broad Challenge Area Biomarker Discovery and Validation (03) and specific Challenge Topic Imaging Biomarkers (03-AR-104) We desire to detect important biomarkers associated with the onset of skin cancers, with a particular emph | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| THE INSTITUTE FOR CANCER RESEARCH | $971,037 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (06) Enabling Technologies, and specific Challenge Topic, 06-CA-117: Cancer Development, Pathology, and Pathological Progression. B cell chronic lymphocytic leukemia (CLL) is the most common leukemia affecti | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $992,113 | Grant | Trans-NIH Recovery Act Research Support: There is a growing body of evidence that supports the idea that malignant tumors are initiated and maintained by a population of tumor cells that share similar biological properties to normal adult stem cells. Cancer stem cells (CSCs) have the ability to | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $971,294 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (13) Smart Biomaterials - Theranostics and specific Challenge Topic, 13-CA-102: Nanotechnology-based multi-functional materials for theranostic applications. The long term goal of this research is to develop | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF MIAMI | $996,077 | Grant | Trans-NIH Recovery Act Research Support: This grant addresses broad Challenge Area (04) Clinical Research, and specific Challenge topic 04-GM-101: Personalized drug response and toxicity. The Challenge and Potential Impact: With a global incidence of 1,151,298 each year, breast cancer is the mos | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF ILLINOIS | $992,343 | Grant | Trans-NIH Recovery Act Research Support: The overall purpose of the study is to examine the mechanisms by which economic incentives offered in food assistance program impact dietary intake of children. We are currently collecting pre-policy implementation baseline data (0 months), and the aims o | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $995,355 | Grant | Trans-NIH Recovery Act Research Support: Treatment for drug use disorders generally consists of relatively brief episodes of care that do not properly address the chronic, relapsing nature of these disorders. In prior work, we have developed a telephone based adaptive continuing care model that | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| WASHINGTON UNIVERSITY, THE | $995,615 | Grant | Trans-NIH Recovery Act Research Support: Damage to inner ear hair cells is a leading cause of human deafness and balance disorders and affects >10% of the world's population. Mammals cannot regenerate their hair cells. However, birds (and other lower vertebrates) can regenerate these cells. This | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF IOWA, THE | $814,755 | Grant | Trans-NIH Recovery Act Research Support: Previous research suggests that an approach that includes a combination of acoustic and electrical stimulation within the same ear can be particularly effective for this group of hearing impaired listeners (von Ilberg et al., 1999; Gantz and Turner, 2003; | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF IOWA, THE | $940,370 | Grant | Trans-NIH Recovery Act Research Support: This research project will investigate the predictors and outcomes of preschool age children's first preventive dental visit, improving our understanding of how age at first preventive dental visit is affected by the psychosocial, behavioral, and social f | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $800,181 | Grant | Trans-NIH Recovery Act Research Support: Tooth loss remains a major health problem in the USA, with up to 40% of residents affected in some regions as a result of dental caries, periodontal disease, trauma, bone loss, or aging. Dental implants are the current state of the art treatment for missi | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $601,810 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (06) Enabling Technologies and specific Challenge Topic, 06-DE-102 Structural and Molecular Atlases of Craniofacial Development. A critical issue for understanding organ development at a systems level is kno | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $999,998 | Grant | Trans-NIH Recovery Act Research Support: Understanding and manipulating gene expression in distinct fat pads as distinct clusters of genes remains a major challenge. We propose that the physiological properties of a given fat pad are the result of the discrete regulation of a relatively small nu | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF MARYLAND | $999,876 | Grant | Trans-NIH Recovery Act Research Support: Essential hypertension is a major threat to public health, affecting over a billion people in the world and contributing to kidney and cardiovascular mortality and morbidity in 5 million people annually. Like other complex disorders, multiple genes with v | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $997,261 | Grant | Trans-NIH Recovery Act Research Support: The specific aims of this study are to 1) identify reliable landmarks and methodology for the measurement of pediatric waist circumference that are associated with intra-abdominal visceral adipose tissue and total body fat across the pediatric age (5 to 1 | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $984,303 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The aim of this proposal is to develop novel, tailored agents than can induce the generation of human fetal red blood cells from adult hematopoietic stem cells by reprogramming -type globin gene regulation. Such agents | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| NORTHWESTERN UNIVERSITY | $997,581 | Grant | Trans-NIH Recovery Act Research Support: This application addresses Broad Challenge Area (06) Enabling Technologies and Specific Challenge Topic 06-OD(OBSSR)-101*, 'Using new technologies to improve adherence' The Diabetes Prevention Program (DPP) intensive lifestyle intervention is the gold sta | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $949,994 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this research is to compare the effectiveness of alternative management strategies (conservative versus dialytic) in stage V (advanced) chronic kidney disease (CKD). Over the past decade, the median eGFR at which dialysis was initiated in | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF NEBRASKA | $997,732 | Grant | Trans-NIH Recovery Act Research Support: The human gastrointestinal tract is colonized by a climax population of microbes (the gut microbiome) that interacts intimately with its host. Linkages between the gut microbiome and host metabolic and immune functions are complex and vital; aberrations i | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: Challenge Area and Topic This proposal addresses the broad Challenge Area (15) Translational Science and the specific Challenge Topic 15-DK-106, Translating basic hematology concepts. Abstract Myelodysplastic syndrome (MDS), similar to a number of other h | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| SMITHS DETECTION, INC. | $986,668 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (15) Translational Science and specific Challenge Topic 15-RR-101 Applied Translational Technology Development. Smiths Detection Diagnostics, in collaboration with the UC | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF PITTSBURGH THE | $999,999 | Grant | Trans-NIH Recovery Act Research Support: General Challenge Area 15: Translational Science. Challenge Topic 15-ES-101: Effects of Environmental Exposures on Phenotypic Outcomes Using Non-Human Models. Monogenic forms of Parkinson disease (PD) are uncommon, accounting for about 10% of all cases | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| DUKE UNIVERSITY | $1,016,785 | Grant | Trans-NIH Recovery Act Research Support: This proposal responds to the (09) Health Disparities broad challenge area and the specific challenge topic: Building Trust Between Researchers and Communities Through Capacity Building in Environmental Public Health (09-ES-101*). African Americans have t | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF MISSOURI SYSTEM | $990,308 | Grant | Trans-NIH Recovery Act Research Support: These studies will permit a further understanding of the assumingly deleterious effects that in utero exposure to bisphenol A can exert in viable yellow (Avy/a) female and male mice and their descendants. Bisphenol A is a toxicant is that commonly found i | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| NEW YORK UNIVERSITY (INC) | $924,863 | Grant | Trans-NIH Recovery Act Research Support: We will implement and rigorously study a housing intervention (window replacement and/or repair) that can simultaneously reduce children's lead exposure, increase energy efficiency, reduce associated power plant emissions, and reduce foreclosures by incre | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $901,280 | Grant | Trans-NIH Recovery Act Research Support: Comparative effectiveness research is an evaluation of the effectiveness and harms of treatment options available for a given health condition. Multiple treatment comparison (MTC) meta-analysis is a meta-analysis technique attracting growing interest beca | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $902,969 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this research is a fundamental understanding of how the eye communicates with the brain. More immediately, the research serves to validate and improve a set of genetic tools for the study of neural circuits. The retina is a complex n | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF KENTUCKY | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: Age-related macular degeneration (AMD) affects as many Americans as all cancers combined and twice as many as Alzheimer's disease. The overwhelming cause of severe vision loss in AMD is choroidal neovascularization (CNV), the growth of abnormal blood vess | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $991,518 | Grant | Trans-NIH Recovery Act Research Support: Correct regulation of gene expression is critical for eukaryotic cells to control proliferation, differentiation or development, and errors in any step of the gene expression program can have severe consequences leading to cell death or disease. Critical | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $998,474 | Grant | Trans-NIH Recovery Act Research Support: Challenge Area of Personalized Drug Response and Toxicity Challenge Topic: 04-GM-101 A. Specific aims It is well established that drug toxicity varied individually. Although some genetic loci have been identified, most of the genetic factors remain to be | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $993,194 | Grant | Trans-NIH Recovery Act Research Support: The goals of this project are to understand parental attitudes toward receiving genetic research results back on their children, and to determine the effectiveness of an oversight board that will address the questions of how to ethical return results to p | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| OHIO STATE UNIVERSITY, THE | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: This application addressed broad challenge area (15), Translational Science, and specific Challenge topic 15-HL-103: Establish the infrastructure to obtain, in a standardized manner, diseased and healthy human cardiac tissue obtained at surgery for immed | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (06) Enabling Technologies and specific Challenge Topic, 06-HL-109: Generate Reagents for Studying Lung Cell Biology and Disease Progression. The application focuses on the compelling need to generate cell-s | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $979,142 | Grant | Trans-NIH Recovery Act Research Support: Molecular imaging techniques with targeted imaging probes have been developed with specific clinical goals in mind. In cardiovascular disease, there is hope that molecular imaging will have a positive impact on patient management by early detection of dis | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF ARIZONA | $958,544 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (03) Biomarker discovery and validation, and specific Challenge Topic, 03-OD-101: Use of epigenetic signatures in blood cells to predict disease. Asthma can currently be managed but not really cured. Therefo | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $999,999 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (05) Comparative Effectiveness Research (CER) and specific Challenge Topic, 05-LM-103: Improving Compliance of School Children with Immunization Schedules. Despite the immense success of the immunization pro | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CHICAGO, THE | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (08) Genomics and Specific Challenge Topic, 08-HL-101* 'Identify causal genetic variants associated with heart, lung, and blood diseases by application of targeted DNA capture and massively parallel sequenci | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF ROCHESTER | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: This RC1 grant application is responsive to Challenge Area 04-Clinical Research and specifically to the NHLBI Challenge Topic 04-HL-103: Assess the role of leukocyte interaction with platelets, erythrocytes, and endothelium in the pathogenesis of heart, l | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| PTC THERAPEUTICS, INC. | $996,430 | Grant | Trans-NIH Recovery Act Research Support: Severe hemophilia A and B (HA/HB) are disabling and life-threatening orphan disorders caused by a genetic defect. No treatments to correct this genetic defect are available. In previous studies in animals and humans, ataluren has shown the potential to tr | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| NORTHWESTERN UNIVERSITY | $999,344 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (14) Stem Cells and specific Challenge Topic, 14-HL-101: Develop molecular signatures for heart, vascular, lung, and blood diseases by profiling reprogrammed induced plur | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: The lack of large animal models of genetic diseases is a serious barrier to reliable testing of the safety and efficacy of new therapies. There are currently no large animal systems whose genomes can be readily manipulated. Many NIDDK diseases lack approp | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF MASSACHUSETTS | $411,072 | Grant | Trans-NIH Recovery Act Research Support: Evaluating Effectiveness of a Statewide Public Mental Health Re-entry Program | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: Contribution of Cis-acting regulatory polymorphisms to Psychiatric Disorders, AR Differences in gene expression patterns between individuals are common, and it has been suggested that the polymorphisms responsible for these differences may account for the | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| DUKE UNIVERSITY | $992,651 | Grant | Trans-NIH Recovery Act Research Support: (03) Biomarker Discovery and Validation general challenge Area and the 03-MH-101 Biomarkers in mental disorders specific challenge topic. Anorexia nervosa (AN) is a terrifying and perplexing disorder. Eating disorders, in general, rank among the top ten c | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $851,691 | Grant | Trans-NIH Recovery Act Research Support: This application addresses Broad Challenge Area (12) Science, Technology, Engineering and Mathematics Education and Specific Challenge Topic 12-OD-104 Innovative approaches to STEM education Project Summary/Abstract This proposal outlines research on usin | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $628,172 | Grant | Trans-NIH Recovery Act Research Support: Previous results have indicated that the motor cortices may execute voluntary movement by selecting and combining muscle synergies organized in the brainstem and/or spinal cord. The specific aims of this research were formulated to test the above hy | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $1,956,421 | Grant | Trans-NIH Recovery Act Research Support: ARRA: BIOMARKER PREDICTION OF GLEASON UPGRADING Over treatment of prostate cancer (treatment that does not extend lifespan) has increased dramatically with the advent of PSA testing. Active surveillance (AS) is an approach to reduce over treatment by care | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| COLD SPRING HARBOR LABORATORY | $2,919,697 | Grant | Trans-NIH Recovery Act Research Support: Each year, more than a million women are diagnosed with breast cancer worldwide. Our understanding of the molecular mechanisms that underlie this disease are advancing rapidly, in part due to an enormous application of resources and effort to this problem | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| NABI BIOPHARMACEUTICALS | $10,007,124 | Grant | Trans-NIH Recovery Act Research Support: ARRA funding, released in September, will help pay for the first phase III trial ever of a smoking cessation vaccine, NicVAX, designed to help people quit and remain abstinent. Given Fast Track Designation by the U.S. Food and Drug Administration, NicVAX | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF MIAMI | $12,292,823 | Grant | Trans-NIH Recovery Act Research Support: Making HIV testing routine is one of the major HIV prevention strategies in the United States. The Centers for Disease Control and Prevention recently recommended that prevention counseling not be required as part of HIV screening programs in medical care | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| ALLTRANZ INC. | $4,013,265 | Grant | Trans-NIH Recovery Act Research Support: TRANSDERMAL CANNABINOID PRODRUG TREATMENT FOR CANNABIS WITHDRAWAL AND DEPENDENCE. Cannabis use disorders affect approximately 1.5% of the United States population, and more than half of the individuals addicted to marijuana experience significant withdraw | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $2,398,656 | Grant | Trans-NIH Recovery Act Research Support: Very little is known about the genetic alterations contributing o the development and progression of oral cancer. Currently, there are no large scale genomic studies addressing these issues, presumably owing to the cost and difficulties associated with su | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $1,612,462 | Grant | Trans-NIH Recovery Act Research Support: The increasing value of medical imaging has resulted in an exponential rise in its use for patient care. Unfortunately, there has been no effective concomitant rise of means to share and communicate these data, resulting in inadequate patient service, co | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF ROCHESTER | $1,360,282 | Grant | Trans-NIH Recovery Act Research Support: Engineered nanomaterials (ENM) have the potential to revolutionize every-day life due to unique properties that have led to advances in electronics, materials science, and drug delivery. Many types of ENM are produced by the metric ton per year and, thus | Health and Human Services, Department of / National Institutes of Health | 9/26/2009 |
| BOSTON COLLEGE, TRUSTEES OF | $2,249,700 | Grant | Trans-NIH Recovery Act Research Support: Modular Software for Sequence Data Quality Checking Alignment and Variant Calling: The purpose of this project is to implement a DNA sequence processing pipeline at the National Center for Biotechnology Information (NCBI) at the NIH. This pipeline is inte | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $1,312,500 | Grant | Trans-NIH Recovery Act Research Support: Large-scale efforts are underway to systematically map transcription factors binding sites throughout the human genome. The ENCODE project has focused its initial attention on two cell lines, 1) K562 cells, a myeloid precursor cell line and 2) GM12878, a | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| ARIZONA STATE UNIVERSITY | $8,425 | Grant | Trans-NIH Recovery Act Research Support: funds for software driven audiometer to accelerate research on the restoration of hearing for deaf patients who qualify for a cochlear implant | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF DELAWARE | $765,048 | Grant | Trans-NIH Recovery Act Research Support: MODULAR SURFACE PLASMON RESONANCE BIOSENSOR FOR IN-VITRO DETERMINATION OF PROTEIN BIOMARKERS This project combines electrokinetic (EK) methods with surface plasmon resonance (SPR) spectroscopy to construct a flexible, modular lab-on-a-chip platform for d | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| SEPULVEDA RESEARCH CORP | $6,507,463 | Grant | Trans-NIH Recovery Act Research Support: This study seeks to elucidate the mechanistic basis of immune responses to factor VIII (FVIII) in some but not all hemophilia A (HA) patients and the increased risk of HA patients with black African ancestry for developing that complication following ther | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF WASHINGTON | $5,155,213 | Grant | Trans-NIH Recovery Act Research Support: This application responds to NHLBI Participation in Research and Research Infrastructure 'Grand Opportunities' (RC2) (RFA-OD-09-004) for Large-scale DNA Sequencing and Molecular Profiling of Well-Phenotyped NHLBI Cohorts. The major goal of this proposal | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF ILLINOIS | $599,048 | Grant | Trans-NIH Recovery Act Research Support: Alarming numbers of pathogenic bacteria are now resistant to multiple antibiotics. This problem is perhaps most pressing for two common hospital-borne pathogens, vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF ILLINOIS | $125,285 | Grant | Trans-NIH Recovery Act Research Support: The use of base analogs as effective antivirals, antimicrobials and anti-cancer agents is limited by their toxicity to the host organism. This toxicity is attributed to either poisoning of the regular nucleotide metabolism by inhibiting key enzymes or to | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $1,735,224 | Grant | Trans-NIH Recovery Act Research Support: Bioethics Initiative For Equity In Health Care And Research At The University Of Texas M. D. Anderson Cancer The overarching goal of the proposed Bioethics Initiative for Equity in Health Care and Research will be to develop a diverse, multidisciplinary, | Health and Human Services, Department of / National Institutes of Health | 9/27/2009 |
| VIRGINIA COMMONWEALTH UNIVERSITY | $4,509,581 | Grant | Trans-NIH Recovery Act Research Support: Schizophrenia is an often devastating neuropsychiatric illness. Genetic factors have been strongly implicated. The genetic contribution to schizophrenia is, however, likely to be complex and difficult to capture by merely considering sequence variation. D | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| COLD SPRING HARBOR LABORATORY | $2,779,842 | Grant | Trans-NIH Recovery Act Research Support: Autistic Spectrum Disorders (ASD) are characterized by delay in or absence of language acquisition, deficits in social interactions and repetitive behaviors. ASD are largely genetic in origin, and occur either sporadically (simplex) or in a familial (mult | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $73,249 | Grant | Trans-NIH Recovery Act Research Support: The study of epigenetic variation is an essential complement to conventional genetic disease studies, since the phenotypic consequence of DNA sequence depends on its epigenetic context. Unlike sequence variation, epigenetic marks, i.e. chemical modificati | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| GEORGETOWN UNIVERSITY (THE) | $236,932 | Grant | Trans-NIH Recovery Act Research Support: Upgrade Existing Multiwell, Fluorescence Timelapse Imaging Workstation | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| INTEGRAL MOLECULAR, INC | $500,000 | Grant | Trans-NIH Recovery Act Research Support: Influenza virus is a Category C biodefense pathogen of global public health concern because it causes 3-5 million cases of severe illness every year, and because of the potential for the emergence of new, highly pathogenic strains that could cause pandemi | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| GEORGETOWN UNIVERSITY (THE) | $1,188,851 | Grant | Trans-NIH Recovery Act Research Support: Dengue viruses (DENV), members of mosquito-borne flaviruses of Flaviviridae family, are included in the NIAID Category A Priority Pathogen as they cause frequent epidemics and serious illness with considerable morbidity and mortality. Two-thirds of human | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON | $1,933,570 | Grant | Trans-NIH Recovery Act Research Support: Chikungunya virus (CHIKV) is an emerging, mosquito-borne alphavirus and potential biological weapon that has caused debilitating, chronic arthralgia in at least 2 million persons in Asia and Africa since 2005. CHIKV was recently placed on the National In | Health and Human Services, Department of / National Institutes of Health | 7/30/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $1,475,393 | Grant | Trans-NIH Recovery Act Research Support: Influenza virus infection causes yearly infections characterized by the abrupt onset of symptoms including fever, myalgia, headache, malaise and chills. Recently, highly pathogenic avian influenza viruses have arisen in aquatic birds and the subsequent zo | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| BAYLOR COLLEGE OF MEDICINE | $1,386,953 | Grant | Trans-NIH Recovery Act Research Support: 'Preclinical development of a therapeutic methamphetamine conjugate vaccine for substance abuse. ABSTRACT: Immunization against methamphetamine (MA) is potentially valuable in assisting patients in stopping their abuse. Vaccines against both nicotine and | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| STOWERS INSTITUTE FOR MEDICAL RESEARCH | $715,500 | Grant | Trans-NIH Recovery Act Research Support: Genetic studies have revealed several key signaling pathways that play a role in the regulation of intestinal stem cells(ISCs)that provide important insight into understanding the capacity of ISCs for renewal and self-repair and differentiation into multi | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $848,466 | Grant | Trans-NIH Recovery Act Research Support: The award entitled G?T-CELL MEDIATED IMMUNITY IN CHLAMYDIA GENITAL INFECTIONG?? examines ways to reduce inflammation of the female reproductive tract. This is important because inflammation or pelvic inflammatory disease (PID) and/or infertility commonly | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| UNIVERSITY OF MARYLAND | $174,903 | Grant | Trans-NIH Recovery Act Research Support: A HETEROLOGOUS EXPRESSION SYSTEM FOR APICOMPLEXA GENES The overarching goal of this study is to develop and validate P. marinus as a heterologous system for producing recombinant proteins from Apicomplexa. For that purpose, we intent to design and constru | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $406,325 | Grant | Trans-NIH Recovery Act Research Support: The majority of pregnant women in malaria-endemic regions contract placental malaria (PM) at some point during gestation. PM is a severe form of malaria, leading to maternal complications, and negatively affecting the survival and growth of the fetus. PM | Health and Human Services, Department of / National Institutes of Health | 5/06/2009 |
| CARNEGIE MELLON UNIVERSITY | $422,125 | Grant | Trans-NIH Recovery Act Research Support: The project long-term goal was to support the development of anti-infective drugs. The focus is Candida albicans, the major invasive fungal pathogen of humans, which causes lethal deep tissue infections and sever mucosal infections. This project will im | Health and Human Services, Department of / National Institutes of Health | 6/17/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $69,998 | Grant | Trans-NIH Recovery Act Research Support: The award was used to purchase an Agilent HPLC. This purchase immediately contributed to employment at Agilent as needed for the production and installation of the instrument as well as the training of individuals in my lab. Moreover, the instrument has i | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| CHILDREN'S HOSPITAL MEDICAL CENTER | $275,026 | Grant | Trans-NIH Recovery Act Research Support: This application is a competitive revision of the parent grant R01GM064619 and is being submitted in response to notice # NOT-OD-09-058. The competitive revision seeks to develop a point-of-care platform for measuring serum zinc concentrations in children | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| CHILDREN'S HOSPITAL MEDICAL CENTER | $114,540 | Grant | Trans-NIH Recovery Act Research Support: The specific aims of the parental grant were to define the role of Fanconi anemia (FA) protein complexes in hematopoiesis. The ARRA supplemental fund continues the line of research proposed in Aim 3 of the parental grant, i.e. to examine whether FA protei | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| CHILDREN'S HOSPITAL MEDICAL CENTER | $12,600 | Grant | Trans-NIH Recovery Act Research Support: Adminstrative Supplement Notice for Students and Science Education under the Recovery Act (NOT-OD-09-060) | Health and Human Services, Department of / National Institutes of Health | 5/30/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $127,000 | Grant | Trans-NIH Recovery Act Research Support: This is a supplement award to an existing grant. The goal is to combine the excellent research and education program at UC Berkeley and train a graduate student in this interdisciplinary research area of bioengineering so that the candidate will become an | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| CHILDREN'S HOSPITAL MEDICAL CENTER | $80,750 | Grant | Trans-NIH Recovery Act Research Support: This award provides partial salary support for a bioinformatician, Walter Jessen, PhD. Dr. Jessen will use bioinformatics to study the differential expression of genes in an EGFR-expressing progenitor-like cell population in human neurofibromas. The awa | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $38,625 | Grant | Trans-NIH Recovery Act Research Support: This project uses zebrafish genetics to understand the molecular and cellular mechanisms underlying the biological effect of ethanol in vivo. | Health and Human Services, Department of / National Institutes of Health | 7/31/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $150,000 | Grant | Trans-NIH Recovery Act Research Support: This research project was directed at further studies to identify the natural CD8+ cell anti-HIV factor (CAF). Over the course of the year, we have made substantial progress in evaluating genes that we found to be associated with CAF production. About 3 | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $321,562 | Grant | Trans-NIH Recovery Act Research Support: The title of this award is Adherence and the Economics of Colon Cancer Screening. The aim of this administrative supplement is to compare programmatic adherence to competing strategies to reduce mortality from colorectal cancer, where programmatic adhere | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| NORTHEASTERN UNIVERSITY | $314,097 | Grant | Trans-NIH Recovery Act Research Support: SURFACE-MODIFIED PHARMACEUTICAL NONOCARRIERS FOR SUBCELLULAR TARGETING | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $735,600 | Grant | Trans-NIH Recovery Act Research Support: This grant provided the research resources for a study of basic mechanisms of optic nerve damage in glaucoma. | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $669,750 | Grant | Trans-NIH Recovery Act Research Support: This award was to fund a grant entitled: The development of direction selectivity in retina. Visual systems are keenly tuned to detect motion in the visual scene. This ability to detect motion is first derived in the retina, the neural tissue that lines t | Health and Human Services, Department of / National Institutes of Health | 6/19/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $235,562 | Grant | Trans-NIH Recovery Act Research Support: This research supports the development of improved computational methods for design of novel human therapeutics using structure-based approaches and approaches based purely on machine learning. The goals are to develop predictive computational techniques | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| KANSAS STATE UNIVERSITY | $190,426 | Grant | Trans-NIH Recovery Act Research Support: The research proposed in this supplement involves a concerted simulation and experimental study of the interaction of peptides with ClpB, a molecular chaperone that uniquely recognizes and targets protein agrregates. The goal is to elucidate the factors i | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| CARNEGIE MELLON UNIVERSITY | $372,287 | Grant | Trans-NIH Recovery Act Research Support: The research supported by this award will lead to a new generation of bright fluorescence imaging agents for detecting and tracking single RNA molecules in living cells. This will be accomplished by covalently attaching fluorescent dyes to a nanostructure | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| ARIZONA STATE UNIVERSITY | $246,413 | Grant | Trans-NIH Recovery Act Research Support: The aim of the parent proposal has been to re-engineer the source code of the Molecular Evolutionary Genetics Analysis software (MEGA). Over the past 16 years, MEGA has been cited in more than 15,000 research publications spanning a diverse range of biolo | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $55,527 | Grant | Trans-NIH Recovery Act Research Support: To purchase a Spectramax M5 Microplate Reader, which is a dual-monochromator, multi-detection microplate reader with the detection modalities. The optics on this plate reader are comparable to a state-of-the-art cuvette fluorometer. | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $60,255 | Grant | Trans-NIH Recovery Act Research Support: Create an easily modifiable Prenatal Testing Program which will reflect changes in the State of California's Prenatal Screening Program and will be used in our ongoing study of an informed free choice approach to prenatal screening of chrom. disorders. | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $182,066 | Grant | Trans-NIH Recovery Act Research Support: The title of grant #R01 HL086917 is The role of nitric oxide synthase in circulating progenitor cell function. The main goal of this project is to determine whether correlations exist between endothelial dysfunction, endothelial progenitor cell dysfuncti | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $881,422 | Grant | Trans-NIH Recovery Act Research Support: Study of MMP-9, which governs damaging and reparative processes in injured spinal cords. A long-term goal is to develop targeted therapeutic interventions to block MMP-mediated adverse events without compromising those functions that facilitate recovery. | Health and Human Services, Department of / National Institutes of Health | 7/29/2009 |
| WAYNE STATE UNIVERSITY (INC) | $304,000 | Grant | Trans-NIH Recovery Act Research Support: This supplement was to the funded RA1 entitled ?A novel and targeted approach to inhibit invasion and angiogenesis? in which there are three specific aims. Aim 1 consists of in vitro analysis of pancreatic cancer cells and the effect of B-DIM. Aim 2 inves | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| ARIZONA STATE UNIVERSITY | $336,552 | Grant | Trans-NIH Recovery Act Research Support: The is a supplement to my R01 through NCRR Behavioral and physiological mechanisms of olfaction. I received a separate ARRA award to purchase a 2-photon microscope. This supplement will allow me to integrate its use into my main research program. This wil | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| NORTHEASTERN UNIVERSITY | $543,566 | Grant | Trans-NIH Recovery Act Research Support: Cancer Immunotherapy by targeting A2 Adenosine Receptors | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF FLORIDA | $139,618 | Grant | Trans-NIH Recovery Act Research Support: Postpartum is a specific event that often results in decreased physical activity (PA) for women; thereby placing this special population at increased risk for several chronic diseases and premature mortality. The existing research examining PA during post | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| RESEARCH TRIANGLE INSTITUTE | $212,929 | Grant | Trans-NIH Recovery Act Research Support: This study will analyze Medicaid administrative data from four states collected between 1999 to 2004 to: (1) assess the usefulness of this data to compare special needs populations with oral and pharyngeal cancers; (2) generate descriptive statistics on t | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| UNIVERSITY OF MARYLAND | $225,000 | Grant | Trans-NIH Recovery Act Research Support: Project Summary Antibodies are highly useful reagents in biotechnological and biomedical applications, yet recombinant antibodies have their limitations. These include the complex architecture of their antigen-binding sites, which complicates the generat | Health and Human Services, Department of / National Institutes of Health | 7/23/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $372,724 | Grant | Trans-NIH Recovery Act Research Support: Award Title: 1R21ES017763-01: Assessing maternal and fetal exposure to chemicals during the second trimester. Purpose: The purpose of this grant is to test several hypotheses surrounding maternal and fetal exposures to bisphenol A (BPA). First, we would | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $540,750 | Grant | Trans-NIH Recovery Act Research Support: Autism spectrum disorders are among the most heritable common disorders, and four times as many males as females are affected. The aims of this proposal comprise a pilot study to investigate the genetic basis for sexual dimorphism in autism. | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| ARIZONA STATE UNIVERSITY | $551,676 | Grant | Trans-NIH Recovery Act Research Support: We introduce transbase tunneling as a new paradigm for read out of DNA sequence using electronic tunneling. Earlier studies have shown tunneling signals across an entire DNA molecule are too small to permit rapid readout of sequence data and tunneling d | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF ILLINOIS | $774,515 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (01) Behavior, Behavioral Change, and Prevention and specific Challenge Topic, 01-AG-102: Neural mechanisms of behavioral change. Cognitive decline in normal aging is a very important societal problem, which | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $840,308 | Grant | Trans-NIH Recovery Act Research Support: 80 individuals have been recruited, 40 with diabetes & 40 controls (each group consisting of 20 with and 20 without fragility fractures). Hr-pQCT, QCT, DXA and MR spectroscopy of the spine have been performed to assess cortical and trabecular bone micro-a | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $951,502 | Grant | Trans-NIH Recovery Act Research Support: We will determine if medial ganglionic eminence (MGE) progenitors, transplanted into the murine spinal cord at a level caudal to the site of spinal cord injury (SCI), will assume a mature inhibitory neuronal phenotype, integrate into local circuitry, and | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| CARNEGIE MELLON UNIVERSITY | $2,657,497 | Grant | Trans-NIH Recovery Act Research Support: INNOVATIVE SUPERCOMPUTING FOR BREAKTHROUGH MOLECULAR DYNAMICS ABSTRACT A partnership between D.E. Shaw Research (DESRES) and the National Resource for Biomedical Supercomputing (NRBSC) at the Pittsburgh Supercomputing Center (PSC) will enable breakthrough | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF ILLINOIS | $84,971 | Grant | Trans-NIH Recovery Act Research Support: Our research program funded by NIH GM080436 (G?Synthesis and Study of Amphotericin B DerivativesG?) aims to harness the power of synthetic organic chemistry to gain a fundamental understanding of the molecular underpinnings of the antifungal activity and | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF ILLINOIS | $979,180 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (01) Behavior, Behavioral Change, and Prevention and specific Challenge Topic, 01-GM-102: Model organisms for social behavior studies. Songbirds offer unique untapped adv | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF ILLINOIS | $967,363 | Grant | Trans-NIH Recovery Act Research Support: A central unsolved question in biology is, What coordinates an organism's circadian clocks? Loss of coordination between the central circadian clock in the brain, the suprachiasmatic nucleus (SCN), and circadian clocks in other cells and tissues has been | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| BUCK INSTITUTE FOR RESEARCH ON AGING | $795,400 | Grant | Trans-NIH Recovery Act Research Support: Aging remains one of the most complex biological mysteries of modern bioscience. This proposal examines how modulation of protein translation plays a key role in determining lifespan. This hypothesis is based on findings from various groups including ours | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| YALE UNIVERSITY | $698,903 | Grant | Trans-NIH Recovery Act Research Support: The majority of studies, including our own preliminary results, support the model that the cells that repair the kidney after acute injury are existing tubule epithelial cells. As proposed in the background and preliminary results, we believe that de-diff | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $770,000 | Grant | Trans-NIH Recovery Act Research Support: The research will focus on understanding the role of kinesin motor proteins in the photoreceptor cilium. The research will use a combination of state-of-the-art in vivo and in vitro approaches to investigate the essential movements of proteins in the pho | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF NEBRASKA | $771,758 | Grant | Trans-NIH Recovery Act Research Support: Sympatho-excitation contributes to the progressive deterioration of cardiac function in severe chronic heart failure (CHF). While we have learned much concerning the central mechanisms for this phenomenon there is still no satisfactory treatment for sympa | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF NEBRASKA | $1,007,177 | Grant | Trans-NIH Recovery Act Research Support: Mucus hypersecretion is a hallmark of obstructive lung diseases, including chronic bronchitis, asthma, and cystic fibrosis. This condition is the result of hypertrophy and hyperplasia of mucus cells. Secreted from goblet cells on the surface epithelium an | Health and Human Services, Department of / National Institutes of Health | 5/30/2009 |
| UNIVERSITY OF MASSACHUSETTS | $706,278 | Grant | Trans-NIH Recovery Act Research Support: The goal of our research is to provide a cellular and molecular understanding of human Rad51-mediated DNA repair. The catalytic activity of Rad51 is of fundamental importance to homologous recombination, a process required for maintenance of genome integ | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $385,000 | Grant | Trans-NIH Recovery Act Research Support: The central tenet of this project is that systemic CD8 T cell memory and intragraft Toll-like receptor (TLR)-dependent pro-inflammatory immune responses represent two major barriers that preclude successful organ engraftment following conventional T cell | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $531,766 | Grant | Trans-NIH Recovery Act Research Support: The long-term objective of this research is to identify, characterize, and exploit drug targets of human herpesviruses. This research is especially health-related, as new drugs are needed for treatment of herpesvirus infections, particularly those of hum | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| JOSLIN DIABETES CENTER, INC. | $201,979 | Grant | Trans-NIH Recovery Act Research Support: Role of IGF-1 and insulin receptors beta-cell survival - A paucity of functional ?-cells is a central feature of type 1 and type 2 diabetes and an urgent question in islet biology relates to plasticity of ?-cell mass in the long-term goal of developing st | Health and Human Services, Department of / National Institutes of Health | 8/21/2009 |
| NORTHEASTERN UNIVERSITY | $198,590 | Grant | Trans-NIH Recovery Act Research Support: 700MHZ Microcoil MNR Probe with Microplate Automation | Health and Human Services, Department of / National Institutes of Health | 4/27/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $259,938 | Grant | Trans-NIH Recovery Act Research Support: Pharmaceutical Sciences and Pharmacogenomics Graduate Program (PSPG) is a cross-disciplinary program that consists of scientists at the University of California, San Francisco (UCSF) working in pharmaceutical sciences, computation and contemporary genetic | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | $729,636 | Grant | Trans-NIH Recovery Act Research Support: Study will gain mechanistic insights on unique immunological properties of HIV positive patients, which will increase the fundamental understanding of immune regulation/HIV infection and provide guidance in designing treatment regimens. | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| ARIZONA STATE UNIVERSITY | $895,511 | Grant | Trans-NIH Recovery Act Research Support: Collections of plasmids, including empty vectors and those with gene inserts, are an invaluable resource to the research community, saving researchers time and money and thus expediting a variety of biological and biomedical experimental applications. Th | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| MAGEE-WOMENS HEALTH CORPORATION | $396,320 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this proposal is to establish an Obstetric-Fetal-Pharmacology Research Unit (OPRU) at the University of Pittsburgh and to summarize the components of the applicant's OPRU. They will demonstrate their willingness to cooperate with other OPRU | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $585,764 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this project is to develop kinetic tools for studying enzyme mechanisms, and to apply them to representative enzymes. During the coming grant period the major emphasis will be on the use of C-13, N-15 and O-18 isotope effects. 1) Isotope ef | Health and Human Services, Department of / National Institutes of Health | 9/08/2009 |
| TEXAS AGRILIFE RESEARCH | $732,500 | Grant | Trans-NIH Recovery Act Research Support: Although biliary excretion of HDL cholesterol is the major route for net cholesterol removal from the body, how hepatocytes so rapidly take up and transfer HDL-derived cholesterol for biliary efflux is unknown. Understanding this process may provide new t | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| CORNELL UNIVERSITY, INC | $697,032 | Grant | Trans-NIH Recovery Act Research Support: Our goal is to estimate the frequency, location, and functional significance of nucleotide variation underlying G?footprintsG? of adaptation in the Drosophila melanogaster genome. The proposed research builds on our successful initial scan using variation | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF MARYLAND | $582,236 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to elucidate thebiochemical mechanism of communication between metabolism and gene transcription. This will be accomplished by measuring the properties of a metabolic enzyme that also functions in transcription regulation. The | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF WASHINGTON | $601,746 | Grant | Trans-NIH Recovery Act Research Support: This ARRA proposal explores cell signaling pathways that occur between cutaneous sensory nerve fibers and endothelial cells during response to cutaneous injury. Wounds persist as a US health care crisis in spite of progress in understanding biological res | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $290,927 | Grant | Trans-NIH Recovery Act Research Support: The principal goals of this research program entail the discovery of new catalytic asymmetric transformations for organic synthesis. Synthetic reactions under investigation include Claisenrearrangements and a iminoester additions. To achieve these goals, | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| COLD SPRING HARBOR LABORATORY ASSOCIATION, INC. | $684,000 | Grant | Trans-NIH Recovery Act Research Support: Heterochromatin was first discovered in plants, but is widespread among eukaryotes and has important roles in chromosome structure, centromere function, gene expression and transposon silencing. Transposable elements (TEs) are major constituents of hetero | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $788,447 | Grant | Trans-NIH Recovery Act Research Support: The hemoglobinopathies comprise the most prevalent class of human genetic diseases. Those involving the ?-globin locus include ?-thalassemia and sickle cell disease (SCD). A variety of observations and experimental results indicate that strategies designe | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| TEXAS A&M UNIVERSITY SYSTEM,THE | $896,985 | Grant | Trans-NIH Recovery Act Research Support: There is currently tremendous enthusiasm for cell-base therapies for heart disease. For example, as of this writing, PubMed cites 6,135 publications under 'stem cells & heart', and 434 under 'stem cells & heart & clinical trial'. Our first application for | Health and Human Services, Department of / National Institutes of Health | 6/22/2009 |
| NORTH DAKOTA STATE UNIVERSITY | $179,659 | Grant | Trans-NIH Recovery Act Research Support: The goal of the parent grant is to establish a Center for Visual and Cognitive Neuroscience (CVCN) at North Dakota State University. One of the CVCN laboratories, supporting the overall goals of CVCN, is the Object Recognition Lab led by Mark Brady. Work | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE | $599,393 | Grant | Trans-NIH Recovery Act Research Support: The objective of this COBRE renewal application is to continue to develop the research careers of promising junior investigators In Cancer Genetics and to build core Programmatic strength in this area. Career development will utilize a strong core of rese | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| MONTANA STATE UNIVERSITY, INC | $399,000 | Grant | Trans-NIH Recovery Act Research Support: This project tests whether a protein produced by human pathogen Group A Streptococcus is a protective antigen with broad protection and how it contributes to the ability of the pathogen to cause infections. We also seek to understand how cells infected wi | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $230,250 | Grant | Trans-NIH Recovery Act Research Support: The supplemental funding was allocated for a collaboration between the University of Kentucky and UC Berkeley to bring highly complementary approaches and strengths for combined remediation approaches using a common iron-based nanoparticle platform. The | Health and Human Services, Department of / National Institutes of Health | 9/10/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $154,116 | Grant | Trans-NIH Recovery Act Research Support: The overall objective of this Superfund Basic Research Program Project on toxic metals is to understand the human health impact of exposure to arsenic and mercury from environmental and anthropogenic sources. This program consists of three biomedical and | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $231,575 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Understanding the cellular and molecular mechanisms of hazardous chemicals in our environment is a critical national objective. The Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) was est | Health and Human Services, Department of / National Institutes of Health | 9/06/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $231,728 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Understanding the cellular and molecular mechanisms of hazardous chemicals in our environment is a critical national objective. The Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) was est | Health and Human Services, Department of / National Institutes of Health | 9/10/2009 |
| UNIVERSITY OF PITTSBURGH THE | $230,569 | Grant | Trans-NIH Recovery Act Research Support: There are very few reports of genomic studies performed in squamous cell carcinoma of the head and neck (SCCHN). The Cancer Genome Atlas has prioritized selected tumors for sequencing and SCCHN is not included in the cancer types sequenced to date or iden | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $172,667 | Grant | Trans-NIH Recovery Act Research Support: The Dana Farber/Harvard Cancer Center (DF/HCC) multiple myeloma (MM) SPORE renewal application consists of 6 Research Projects and 3 Cores, as well as the Career Development and Developmental Research Programs. During the previous funding period, we have | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC. | $256,642 | Grant | Trans-NIH Recovery Act Research Support: The 5-year survival from lung cancer has kept pace with the improvement in 5-year survival from all cancers over the last 40 years. Yet, it remains disappointingly low at -15%. This improvement in 5-year survival is a result of heightened awareness, bette | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $51,433 | Grant | Trans-NIH Recovery Act Research Support: This proposal for an Administrative Supplement for our P50 for the O Brien Urology Research Program entitled Bladder Wall remodeling in LUTS (2P50 DK052620 11). This Research Program addresses the cellular molecular mechanisms that cause stress and ob | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $421,456 | Grant | Trans-NIH Recovery Act Research Support: The O Brien Urology Research Program addresses the cellular molecular mechanisms that cause stress and obstruction induced lower urinary tract symptoms (LUTS). . The three new P and F projects that are included in the Administrative Supplement. Th | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF MIAMI | $309,166 | Grant | Trans-NIH Recovery Act Research Support: Continuing scientific progress in Parkinson disease (PD) and other parkinsonian syndromes relies upon accurate diagnosis of these disorders and the availability of patients and controls for study. The ongoing efforts of the current Ascertainment and Clin | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF KENTUCKY | $663,511 | Grant | Trans-NIH Recovery Act Research Support: Arsenic remains a top environmental concern in the United States as well as world-wide because of its global existence and serious health impacts. Epidemiological studies provide ample evidence that arsenite exposure is associated with the increased incid | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $389,950 | Grant | Trans-NIH Recovery Act Research Support: The underlying hypothesis of this funded grant is that knowledge of the genes that can suppress apoptosis in thymocytes and cancer cells overexpressing BCL-2, after treatment with radiation or drugs that induce DNA damage, will implicate relevant, and dru | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $145,903 | Grant | Trans-NIH Recovery Act Research Support: Targeted dendrimer-based nanodevices have shown excellent promise in both in vitro cell culture and in vivo animal studies as cancer therapeutics. However, each device must be custom synthesized for a particular set of targeting molecules, imaging agents, | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| THE CHILDRENS HOSPITAL LOS ANGELES | $222,321 | Grant | Trans-NIH Recovery Act Research Support: There are 4 specific Aims in our parent grant, of which Aims, 1 and 4 focus on determining the mechanisms of granulocytic in both normal human hematopoietic stem cells (HSC) and myeloid leukemia cells. We have succesfully completed some of the proposed e | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $531,689 | Grant | Trans-NIH Recovery Act Research Support: The goal of this research is to identify novel susceptibility genes for lung cancer using a systematic genome- wide association-based approach. To achieve this goal, we are applying a two-stage design. This proposal builds upon an extensive resource of lu | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| MAYO CLINIC | $301,942 | Grant | Trans-NIH Recovery Act Research Support: Breast cancer is the most frequent malignancy in women, and is associated with significant morbidity and mortality. Few commonly inherited genetic alterations that contribute to the etiology of this disease have been defined. The goal of our ongoing study | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | $19,158 | Grant | Trans-NIH Recovery Act Research Support: The goal of the parent grant is to understand the lung cancer preventive activities of tea constituents and their applications to human cancer prevention. These specific aims are described as follows: 1. Establish and compare in vivo (xenograft/allograft) | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $677,167 | Grant | Trans-NIH Recovery Act Research Support: Using high resolution comparative genomic hybridization (CGH) array analysis of 235 ovarian cancers, we have narrowed the most frequent region of copy number increase in ovarian cancers to an ~3.2 MB wide region at 3q26.2. Real time PCR of genes within th | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| FOX CHASE CANCER CENTER | $349,000 | Grant | Trans-NIH Recovery Act Research Support: 5-aminosalicylic acid (5-ASA) represents a promising agent for the chemoprevention of colorectal cancer in patients with ulcerative colitis. However, the precise molecular mechanism by which 5-ASA inhibits tumor formation remains unclear and is most like | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF HAWAII SYSTEMS | $1,802,665 | Grant | Trans-NIH Recovery Act Research Support: Common inherited DNA variants are expected to play an important role in colorectal cancer (CRC). However, the main effects for these variants are likely to be weak because as much as 75-80% of CRC cases are 'explainable' by known or suspected lifestyle ri | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $27,000 | Grant | Trans-NIH Recovery Act Research Support: Hepatic fibrosis represents an important turning point in a number of chronic liver pathologies including alcohol abuse, viral infection, and chronic cholestasis. The mechanisms governing the initiation and propagation of this response are not well unders | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $108,000 | Grant | Trans-NIH Recovery Act Research Support: I have spent all of my professional training involved in the study of neurodegenerative disease with an early background in Parkinson's disease, and a purposefully sought postdoctoral position in the laboratory of Dr. Dennis Selkoe at the Center for Neuro | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| WAKE FOREST UNIVERSITY | $66,179 | Grant | Trans-NIH Recovery Act Research Support: We propose to utilize the requested resources to support additional personnel to perform supplementary research to confirm and expand upon the scientific discoveries expected in the parent grant. The primary goal of this supplement to K01 AG030506 is to | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO ,THE | $50,000 | Grant | Trans-NIH Recovery Act Research Support: The goal of this supplement is to complete the characterization of a particularl skeletal phenotype of a transgenetic mouse that have been generated for the parent grant. | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF ARKANSAS SYSTEM | $108,000 | Grant | Trans-NIH Recovery Act Research Support: A challenge still facing the biomedical community is the development of therapeutic strategies to tackle cancer. This research will have high impact on the development of future target-based therapeutic design because these studies will showcase, as yet, | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| TEXAS A&M UNIVERSITY SYSTEM,THE | $99,665 | Grant | Trans-NIH Recovery Act Research Support: This research is directed at elucidating how the transcription factor NF-KB responds to diverse extracellular signals to control fundamental processes, such as cell proliferation, apoptosis and malignant transformation. Because NF-KB can promote cell surv | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $83,551 | Grant | Trans-NIH Recovery Act Research Support: Lung cancer is the leading cause of cancer mortality in the United States. African American men have the highest incidence and mortality for lung cancer in the US, and yet continue to obtain treatment at lower rates than White patients. The causes of raci | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| BAYLOR COLLEGE OF MEDICINE | $48,114 | Grant | Trans-NIH Recovery Act Research Support: GLP-2 is an intestinotrophic growth factor that stimulates mucosal growth by increasing crypt cell proliferation and decreasing enterocyte cell apoptosis. GLP-2 also stimulates intestinal blood flow, improves nutrient absorption, and inhibits gut motility | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| UNIVERSITY OF HOUSTON SYSTEM | $53,954 | Grant | Trans-NIH Recovery Act Research Support: We have recently shown that Toll-like receptors (TLRs) are involved in regulation of gene expression of drug metabolizing enzymes1, 2. The overall goal of this project is to determine the role of these receptors in the regulation of drug metabolism and to | Health and Human Services, Department of / National Institutes of Health | 7/31/2009 |
| NEW YORK MEDICAL COLLEGE | $95,400 | Grant | Trans-NIH Recovery Act Research Support: Long-lasting activity-dependent alterations in the strength of synaptic connections are thought to be essential substrates of memory. Long-term potentiation (LTP) of synaptic transmission has been heavily studied, long-term depression (LTD) of synapse st | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $156,225 | Grant | Trans-NIH Recovery Act Research Support: The immune reconstitution inflammatory syndrome (IRIS) is a frequent complication of antiretroviral therapy in HIV+ individuals. IRIS is described as an inflammatory reaction at the site of infection with numerous opportunistic pathogens, caused by a reco | Health and Human Services, Department of / National Institutes of Health | 8/19/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $26,437 | Grant | Trans-NIH Recovery Act Research Support: Multiple forms of activity dependent, synaptic plasticity have been described in the cerebellar cortex. Hypothesized to play a central role in motor learning, the overall goal of this proposal is to address key questions concerning cerebellar synaptic pla | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $45,072 | Grant | Trans-NIH Recovery Act Research Support: Dopamine neurons are functionally important neurons, yet the genetic mechanisms that program their correct development are poorly understood. In the parent grant to this administrative supplement, we have proposed to isolate and characterize genes involve | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $194,671 | Grant | Trans-NIH Recovery Act Research Support: This project will have the dual impact of job creation and scientific advancement in the critically important yet underserved area of TBI. Such information is critical to provide important insight into the mechanisms underlying the persistent cognitive de | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| REGENERATIVE RESEARCH FOUNDATION | $282,534 | Grant | Trans-NIH Recovery Act Research Support: The overall purpose of the award is to further our understanding on neural stem cells and their interacting components in the adult SVZ niche and gain insight of molecular mechanisms regulating neural stem cell behavior in vivo. The award helps bring the | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $144,330 | Grant | Trans-NIH Recovery Act Research Support: NMDA receptors (NRs) mediate fast excitatory transmission in the brain. Their activation is critical for the normal development, maintenance and continual remodeling of excitatory synapses. Excessive NR activity is a disease mechanism in stroke, chronic p | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $151,946 | Grant | Trans-NIH Recovery Act Research Support: Neural stem cells reside in specialized niches in the adult mammalian brain and continuously generate new neurons that functionally integrate into neural circuits. Adult neural stem cells may represent a pool of cells that can be stimulated for brain rep | Health and Human Services, Department of / National Institutes of Health | 8/19/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $79,000 | Grant | Trans-NIH Recovery Act Research Support: The Research Plan describes a series of experiments that will examine how spatial information is processed in the mammalian brain. In previous studies a population of neurons was identified within the mammillary nuclei --> anterior thalamus --> hippocampa | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| LOMA LINDA UNIVERSITY | $326,831 | Grant | Trans-NIH Recovery Act Research Support: We are using two promising MR techniques Susceptibility- Weighted Imaging (SWI) and Magnetic Resonance Spectroscopic Imaging (MRSI), acquired early after TBI to determine whether they are better at evaluating TBI severity by showing that injury is present | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| PACIFIC INSTITUTE FOR RESEARCH AND EVALUATION | $4,621 | Grant | Trans-NIH Recovery Act Research Support: This exploratory study is the first step in a larger research agenda to investigate the impact of two distinct types of state laws regarding alcohol use during pregnancy (public health-oriented or punitive) on pregnant women's decisions to seek substance | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $132,635 | Grant | Trans-NIH Recovery Act Research Support: The survival curve of genetically identical individuals is a powerful tool in the study of aging. A robust technology for the automated and inexpensive generation of high-resolution survival curves of large worm (C. elegans) populations will have broad im | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $69,795 | Grant | Trans-NIH Recovery Act Research Support: The long term goal of this research is to identify virulence factors that may be targeted for the design of effective vaccines and therapeutics for Neisseria gonorrhoeae (GC), which causes gonorrhoeae and pelvic inflammatory disease, and Neisseria meningi | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| MAYO CLINIC | $99,998 | Grant | Trans-NIH Recovery Act Research Support: The Building Partnerships to Promote Health in Low Literacy Populations project has already successfully united the medical/research community with the Hawthorne community to increase understanding of community-based participatory research (CBPR) and to r | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| FOX CHASE CANCER CENTER | $9,180 | Grant | Trans-NIH Recovery Act Research Support: As the second largest employer in Northeast Philadelphia, Fox Chase Cancer Center (FCCC) provides a substantial economic impact locally that extends beyond the immediate area to provide economic benefits regionally, throughout the Pennsylvania, Delaware a | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF ILLINOIS | $13,502 | Grant | Trans-NIH Recovery Act Research Support: The award was the support of summer research students as a supplement for a currently funded RO3. The goal of our study is to elucidate the molecular mechanisms underlying periodontal pathology in psychological stress. The aim of the proposal was to explo | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| LOYOLA UNIVERSITY NEW ORLEANS | $13,618 | Grant | Trans-NIH Recovery Act Research Support: Chagas disease is the most serious parasitic disease and a leading cause of heart disease in Latin America. It has been difficult to control in Central America and Mexico since the main species of insect that spreads the parasite, Triatoma dimidiata, is f | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $229,875 | Grant | Trans-NIH Recovery Act Research Support: During chronic human immunodeficiency virus (HIV) infection, HIV-specific T cells fail to control viral replication, in part because they lose the ability to proliferate, produce cytokines, and lyse infected target cells. Functional restoration of HIV-spe | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $222,455 | Grant | Trans-NIH Recovery Act Research Support: Engagement of IgG Fc receptors (Fc?Rs) on natural killer cells, monocytes, macrophages, or dendritic cells may play a critical role in preventing lentivirus infection. For example, a broadly neutralizing monoclonal antibody (IgG1 b12) provides far more co | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| NATIONAL CHILDHOOD CANCER FOUNDATION | $684,650 | Grant | Trans-NIH Recovery Act Research Support: This award provides support for Adoption of New Technologies for Remote Data Capture and Protocol Authoring (ADOPT) for the Phase III Clinical Trials. The components of the project are: (1) integration and training with electronic Protocol Authoring (ePA | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF UTAH, THE | $84,657 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): As electronic health records (EHRs) continue their expansion into clinical settings, there has been a corresponding increase in interest in mining the data they contain, both for research as well as for clinical decisi | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| UNIVERSITY OF MARYLAND | $25,299 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this project is to develop a rat model for the neuropathological and behavioral deficits of schizophrenia that can be used to analyze the neurobiological basis of schizophrenia-like behavioral deficits and to identify novel targets f | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $243,548 | Grant | Trans-NIH Recovery Act Research Support: A fundamental challenge of contemporary neuroscience is to define causal relationships between the activity of a given brain circuit and a particular animal behavior, including the developmental and molecular events that tie this relationship together. In | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF SOUTHERN MISSISSIPPI | $569,209 | Grant | Trans-NIH Recovery Act Research Support: This project trains and employs community members in a health disparity community to engage in intervention and community-building activities to increase physical activity and improve healthy food choices as part of a community-wide effort to promote heal | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| LOUISIANA STATE UNIVERSITY (INC) | $369,468 | Grant | Trans-NIH Recovery Act Research Support: This supplement project will accelerate and enhance research in the parent grant by creating microdevices for rapid activation and assessment of sperm motility, so that optimal cryopreservation methods can be standardized for high-throughput operations. T | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| THE VANDERBILT UNIVERSITY | $3,000,000 | Grant | Trans-NIH Recovery Act Research Support: The Fogarty International Clinical Research Scholars & Fellows Support Center @ Vanderbilt University G?? Association of American Medical Colleges (FICRS?F) requests an administrative increase for the Fogarty International Clinical Research Scholars Suppo | Health and Human Services, Department of / National Institutes of Health | 6/20/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $84,914 | Grant | Trans-NIH Recovery Act Research Support: Short Research Experiences in Cancer at Louisiana State University Health Sciences Center (LSUHSC) was launched in 1988 as a way to give talented high school, undergraduate, and medical students, an in-depth exposure to cancer research. In twenty years, 3 | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE | $89,470 | Grant | Trans-NIH Recovery Act Research Support: The primary aim of this training proposal is to improve quality of care and quality of life for cancer survivors. As of January 2007, there are an estimated 9.8 million cancer survivors representing 3.5% of the population. As cancer survival has increased | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| HEALTH RESEARCH, INC. | $248,377 | Grant | Trans-NIH Recovery Act Research Support: This proposal is being submitted in response to NOT-OD-09-058, titled 'NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications.' We propose to expand our NCI R25T funded postdoctoral training program in prevention with t | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| VIRGINIA COMMONWEALTH UNIVERSITY | $134,929 | Grant | Trans-NIH Recovery Act Research Support: The ultimate goal of the VCU STEP-Up program is to increase numbers of underrepresented individuals in the biomedical research workforce in areas within the mission of the National Institute for Diabetes, Digestive, and Kidney Diseases (NIDDK). To accompl | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $1,399,999 | Grant | Trans-NIH Recovery Act Research Support: In this center grant we propose to study interactions of Category A, B and C viruses with human primary cells resulting in induction of innate and adaptive immune responses. Our investigations will be focused on viral mechanisms of induction and subversio | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| MEDICAL COLLEGE OF WISCONSIN, INC., THE | $284,103 | Grant | Trans-NIH Recovery Act Research Support: This supplement will further our understanding of the mechanisms underlying the multiple organ system failure that occurs following total body irradiation (TBI), and help us to develop medical countermeasures to mitigate and treat such injury. Our prelim | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| WESLEYAN UNIVERSITY | $829,500 | Grant | Trans-NIH Recovery Act Research Support: Project Summary Bacterial resistance to l3-lactam antibiotics continues to become more prevalent and more clinically important. A large part of the resistance can be understood and investigated experimentally in terms of the chemistry of the interactions | Health and Human Services, Department of / National Institutes of Health | 7/30/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $867,655 | Grant | Trans-NIH Recovery Act Research Support: During the last funding interval as a merit award, this grant focused on the T cell receptor (TCR) complex composed of an +?+? heterodimer and non-covalently associated CD3 signaling components. We continued crystallographic analysis with TCRs, providing | Health and Human Services, Department of / National Institutes of Health | 9/08/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $734,255 | Grant | Trans-NIH Recovery Act Research Support: This grant provides RO1 level funding for studies on the mechanism and function of alternative mRNA editing in African trypanosomes. RNA editing in trypanosomes is a remarkable post-transcriptional process that results in the formation of mitochondrial m | Health and Human Services, Department of / National Institutes of Health | 7/23/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $847,006 | Grant | Trans-NIH Recovery Act Research Support: The long term goals of this project are to understand the immunobiology of asthma and allergic diseases. In the current application, we propose to examine the characteristics and function of Natural Killer T (NKT) cells, which we and others have shown to | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| ROCKEFELLER UNIVERSITY FACULTY AND STUDENTS CLUB INC, THE | $845,000 | Grant | Trans-NIH Recovery Act Research Support: Carbohydrate binding proteins of the C-type lectin family are involved in the mechanisms by which cell traffic during an inflammatory response, in the processes of immune cell activation and in the recognition of pathogens through the binding of microbial | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $516,600 | Grant | Trans-NIH Recovery Act Research Support: A broad range of molecules and cell types have been implicated in the development of burn complications. However, it is still not clearly understood how the complex network of post-burn pathologic events is coordinated. Endogenous retroviruses (ERVs) are | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $452,919 | Grant | Trans-NIH Recovery Act Research Support: Meiosis is a critical cell division, specific to the germ line of all animals. During meiosis, complex mechanisms regulate accurate chromosome segregation in order to produce mature gametes. The inheritance of an abnormal chromosome number through defecti | Health and Human Services, Department of / National Institutes of Health | 7/24/2009 |
| UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC. | $710,308 | Grant | Trans-NIH Recovery Act Research Support: The Na,K-ATPase transporters comprise a group of relatively ubiquitous plasma membrane isozymes that use the energy from the hydrolysis of ATP to exchange cytoplasmic Na+ for extracellular K+. Isozyme diversity for the Na,K-ATPase results from the associ | Health and Human Services, Department of / National Institutes of Health | 8/24/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $936,240 | Grant | Trans-NIH Recovery Act Research Support: Demographic studies have shown that the mean age of patients requiring coronary artery bypass surgery (CABG) is 68 years with approximately 44% of these patients being female. Women have been shown to have a significantly greater operative risk and to hav | Health and Human Services, Department of / National Institutes of Health | 8/12/2009 |
| WASHINGTON UNIVERSITY, THE | $617,042 | Grant | Trans-NIH Recovery Act Research Support: In the heart, a major sensor of the metabolic state, and hence a potentially major player in ischemia, is the ATP-sensitive potassium (KATP) channel, which links metabolic state to electrical excitability. This project seeks to understand the molecular ba | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $999,943 | Grant | Trans-NIH Recovery Act Research Support: A basic science NIH research grant entitled 'Plasticity in Airway Smooth Muscle'. Prior experiments showed that airway smooth muscles, which is responsible for asthma, can adapt to a very wide range of length. The purpose of the present studies are 2-fold | Health and Human Services, Department of / National Institutes of Health | 5/30/2009 |
| UNIVERSITY OF CINCINNATI | $1,111,765 | Grant | Trans-NIH Recovery Act Research Support: Our objective is to understand the mechanisms by which the NHE1 Na/H exchanger and the AE1, AE2, AE3, and PAT1 (Slc4a1-3 and Slc26a6) Cl/HCO3 exchangers affect cardiac Ca handling, contractility, and metabolism. These acid-base transporters comprise a rob | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $889,633 | Grant | Trans-NIH Recovery Act Research Support: Anionic polymers such as F actin and DNA found in the airway fluid of cystic fibrosis (CF) patients and other infected sites are strong inhibitors of endogenous cationic antimicrobial peptides such as those produced at the airway epithelium. This revised | Health and Human Services, Department of / National Institutes of Health | 5/30/2009 |
| MAYO CLINIC | $667,981 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this proposal is to address the clinical problem of detecting impairment of myocardial microcirculatory function, such as occurs in atherosclerosis, prior to symptoms due to narrowing of epicardial coronary arteries or due to myocardia | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF MONTANA SYSTEM | $132,625 | Grant | Trans-NIH Recovery Act Research Support: The funds of this project will be used to support two senior associates Dr. Thomas to perform molecular biological, enzymological and NMR studies of Ric-8A as proposed in Aim2 and Dr. Tung-Chung Mou to manage our X-ray diffraction facility and to conduct | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| RETINA FOUNDATION OF THE SOUTHWEST | $852,646 | Grant | Trans-NIH Recovery Act Research Support: Congenital and early onset binocular imbalance, including esotropia, anisometropia, and cataracts, affect 2-4% of infants in the U.S. Early binocular imbalance can cause amblyopia and abnormal binocular vision. Over 90% of patients with congenital and ear | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| GEORGE MASON UNIVERSITY | $1,007,844 | Grant | Trans-NIH Recovery Act Research Support: Using Rewards in Justice Treatment Programs: Technology & Contingency Management: This study is designed to develop knowledge about how technology can be used in criminal justice settings to assess performance, either at the individual client level or at | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF ROCHESTER | $2,275,663 | Grant | Trans-NIH Recovery Act Research Support: This application responds to RFA OD-08-001 Rare Diseases Clinical Research Consortia (RDCRC) for the Rare Diseases Clinical Research Network and proposes the renewal of U54 # NS059065 Nervous System Channelopathies: Pathogenesis and Treatment, focusing on | Health and Human Services, Department of / National Institutes of Health | 9/20/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $50,000 | Grant | Trans-NIH Recovery Act Research Support: Candidate: Dr. Neely is an Assistant Professor of Clinical Pediatrics with subspecialty training in infectious diseases and clinical pharmacology. For the last 4 years he has been using population pharmacokinetic (PK) modeling to measure adherence to anti | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $108,000 | Grant | Trans-NIH Recovery Act Research Support: The career objective of the K23 candidate is to become a rheumatic disease epidemiologist. In the context of mentored research, Dr. Curtis will examine the incidence, risk factors, and outcomes related to osteoporosis, with an emphasis on African American | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| SOUTHERN ILLINOIS UNIVERSITY | $16,694 | Grant | Trans-NIH Recovery Act Research Support: Our parent NIH grant has two specific aims: (1) developing new synthetic routes for constructing dendron-coated iron oxide nanoparticles (?SPIONs?) that have various surface electrostatics and other properties; and (2) examining the NMR relaxation-inducin | Health and Human Services, Department of / National Institutes of Health | 5/28/2009 |
| MIAMI UNIVERSITY | $69,580 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This project is concerned with the dispersal of fungal spores in the indoor environment. At a time of widespread concern about microbial contamination of buildings, this project is motivated by the following questions: | Health and Human Services, Department of / National Institutes of Health | 7/10/2009 |
| UNIVERSITY OF KENTUCKY | $124,889 | Grant | Trans-NIH Recovery Act Research Support: Innate and acquired immune responses in the intestine must promote homeostasis in the presence of large numbers of commensal microorganisms, while maintaining the capacity to defend the body against invasive pathogens. The adult human intestinal tract is | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| MISSOURI SYSTEM, UNIVERSITY OF | $16,206 | Grant | Trans-NIH Recovery Act Research Support: In our original proposal, we set out to adapt genetic tools available for work with the select agent pathogen Yersinia pestis such that the use of antibiotic resistance markers could be reduced or eliminated. This research is necessary to enable progress | Health and Human Services, Department of / National Institutes of Health | 6/17/2009 |
| COMPACT MEMBRANE SYSTEMS, INC. | $265,534 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Compact Membrane Systems, Inc. is proposing a revision to grant 1 R43 GM084478-01A1 entitled Contaminate Removal for Laboratory Pharmaceutical Synthesis in response to notice NOT-OD-09-058, NIH Announces the Availabili | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| CARINGFAMILY, LLC | $459,424 | Grant | Trans-NIH Recovery Act Research Support: This award provides additional funding for 5R44AG024014-03: Connecting Elders, Empowering Caregivers. Residents of assisted living have extraordinary potential to benefit from interventions that enhance their social networks and rates of contact because | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF FLORIDA | $85,500 | Grant | Trans-NIH Recovery Act Research Support: The supplemental ARRA funds requested herein will immediately be employed towards achieving the stated goals of Project 3 within this PO1, as well as accelerate the pace of scientific discovery while stimulating the economy. Specifically, we are requestin | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UMDNJ-ROBERT WOOD JOHNSON MEDICAL SCHOOL | $655,862 | Grant | Trans-NIH Recovery Act Research Support: This program project is focused to coordinate the efforts of five investigators who have been studying post-transcriptional regulation, in particular, the mechanisms involved in mRNA turnover. In collaborative efforts, the investigators have developed a b | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF NEBRASKA | $640,079 | Grant | Trans-NIH Recovery Act Research Support: The Nebraska Research Network in Functional Genomics has two major components, the undergraduate campuses located throughout the State and the research campuses located in Omaha and Lincoln. On the undergraduate campuses, INBRE will support 24 faculty dir | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $294,889 | Grant | Trans-NIH Recovery Act Research Support: To investigate the therapeutic implications of the current paradigm that autoimmune disease can result from defects in the clearance of dying/apoptotic cells, we have conducted preliminary studies that have shown that infusions of a natural antibody deriv | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| UNIVERSITY OF PITTSBURGH THE | $33,809 | Grant | Trans-NIH Recovery Act Research Support: The goal of this supplement is to recruit for additional needed skills. A person has been identified for this position. She will add new skills and techniques that are currently not part of this grant application. She will perform molecular biology dev | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY | $207,044 | Grant | Trans-NIH Recovery Act Research Support: How IL-10R blockade can resolve persistent viral infections: The ARRA funded diversity supplement to R01 AI068818-01A2 has been awarded to directly support the work of Dr. Baca Jones in the von Herrath laboratory. The diversity supplement was designed to | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $56,402 | Grant | Trans-NIH Recovery Act Research Support: HIV-1 Integrase Structural Biology | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| CORNELL UNIVERSITY, INC | $104,036 | Grant | Trans-NIH Recovery Act Research Support: Rapid and accurate recognition of invading pathogens is critical for survival from infectious diseases. Toll-like receptors (TLRs) are a family of innate receptors poised to rapidly recognize components of infectious organisms. Originally it was thought t | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $780,538 | Grant | Trans-NIH Recovery Act Research Support: The overarching goal of this Competitive Revision [Notice Number (NOT-OD-09-058) and Notice Title (?NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications?)] is to expand the scope of our current grant, ?In-Home Prevent | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE | $385,000 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The current proposal compares adolescent and adult rats, both before and after cocaine self-administration, to appraise whether inherent or drug-induced changes in dopamine cell activity could underlie adolescent addic | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| OREGON SOCIAL LEARNING CENTER | $35,792 | Grant | Trans-NIH Recovery Act Research Support: The KITS: School Readiness in Foster Care Efficacy Trial is a 5-year randomized trial of a preventive intervention to enhance psychosocial and academic school readiness in foster children as they enter school. The purpose of this award was to provide unde | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| MAYO CLINIC | $732,603 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this competitive revision is a rigorous evaluation of the potential of engineered cocaine hydrolases alone and in combination with antibodies to ameliorate cocaine toxicity and cocaine abuse by preventing cocaine access to targets. Our | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| SOUTH CAROLINA RESEARCH FOUNDATION | $56,550 | Grant | Trans-NIH Recovery Act Research Support: HALOACETAMIDINE BASED INACTIVATORS OF PROTEIN ARGININE DEIMINASE 4 The overall goal of this supplemental proposal is to develop and use a highthroughput screen (HTS) to discover inhibitors for Protein Arginine Deiminase 4 (PAD4), a calcium regulated enzy | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $169,500 | Grant | Trans-NIH Recovery Act Research Support: This Administrative Supplement Award (parent grant : National Institutes of Health GM079388) is for introducing a new Nuclear Magnetic Resonance technology to our lab that is crucial for the successful completion of Aims 1 and 2 of the parent grant. It is | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC. | $269,440 | Grant | Trans-NIH Recovery Act Research Support: To fully interpret differences between patient genomes, we must improve our understanding of the protein sequence/function relationship. Since experimental characterization of all protein polymorphisms is impossible, myriad bioinformatics algorithms are b | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| DUKE UNIVERSITY | $238,151 | Grant | Trans-NIH Recovery Act Research Support: Ankyrin (ANK) repeats, identified in thousands of proteins, are composed of pairs of antiparallel alpha- helices that stack on top of each other and form super-helical spiral domains with suggestive spring-like properties, whose primary function is to med | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $187,582 | Grant | Trans-NIH Recovery Act Research Support: This two year administrative supplement will focus on aspects of EnvZ OmpR signaling and other two component signaling systems that are a direct outgrowth of the work of the parent grant. The first aim will determine the variability in properties of the E | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF ILLINOIS | $989,100 | Grant | Trans-NIH Recovery Act Research Support: This award was issued as a 2 year extension of previous NIH grant 1R01 HD044713-01A2. Project Title: Cell differentiation during decidualization. / Differences in cytoskeletal organization and properties of stromal cells in endometriosis. Decidualizatio | Health and Human Services, Department of / National Institutes of Health | 7/28/2009 |
| WASHINGTON UNIVERSITY, THE | $1,187,823 | Grant | Trans-NIH Recovery Act Research Support: Project is on No Cost Extension through 6/30/12. A number of hormones and membrane proteins bear carbohydrate chains that contain unique sugars with unusual modifying groups such as sulfate. The attachment of these unique sugars is critical for regulatin | Health and Human Services, Department of / National Institutes of Health | 7/28/2009 |
| UNIVERSITY OF ARIZONA | $674,264 | Grant | Trans-NIH Recovery Act Research Support: The long term goals of this research are to develop a multi disciplinary research that provides a systematic, rational, three dimensional approach to the design and synthesis of potent receptor/acceptor selective peptide and peptide mimetic ligands for pe | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $913,419 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this proposal is to understand the mechanism of canalicular bile formation and cholestasis. Our present understanding of the pathogenesis of cholestasis is based on studies to define the physiological regulation of transporters invol | Health and Human Services, Department of / National Institutes of Health | 8/25/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $762,505 | Grant | Trans-NIH Recovery Act Research Support: To characterize and define the role of MEG3, a pituitary derived gene, to increase the understating of its role in human pituitary tumors which represent up to 40% of all diagnosed pituitary neoplasms. These tumors commonly lead to visual loss and many ot | Health and Human Services, Department of / National Institutes of Health | 5/26/2009 |
| CHILDRENS HOSPITAL OF PHILADELPHIA | $831,438 | Grant | Trans-NIH Recovery Act Research Support: Transcription factor GATA-1 is critical for the development of multiple blood lineages, including erythroid cells, megakaryocytes, mast cells and eosinophils. Mutations in the Gata1 gene underlie a variety of congenital and acquired hematological disorder | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| CHILDREN'S HOSPITAL & RESEARCH CENTER | $645,010 | Grant | Trans-NIH Recovery Act Research Support: This is a translational research proposal to elucidate the mechanisms underlying apparent differences in end-organ iron deposition between patients with sickle cell anemia (SCD), thalassemia (TM) and Diamond Blackfan Anemia (DBA). Increasing numbers of | Health and Human Services, Department of / National Institutes of Health | 9/10/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $253,398 | Grant | Trans-NIH Recovery Act Research Support: This application is for the renewal of R01 AI45463 ?Modified envelope glycoproteins for HIV-1 vaccine?, a grant first awarded in 1999, re-awarded in 2004, and now being re-competed. Our goals remain the same: To design vaccines intended to induce neutra | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| COLORADO STATE UNIVERSITY | $582,716 | Grant | Trans-NIH Recovery Act Research Support: Mosquito-borne viral diseases remain significant causes of morbidity and mortality throughout much of the world and impose tremendous burdens on human and animal care infrastructures. It is critical that we have a better understanding of the molecular bas | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| DUKE UNIVERSITY | $780,000 | Grant | Trans-NIH Recovery Act Research Support: 'The overall goal of the proposed research is to further elucidate mechanisms of allogeneic stem cell education in patients with severe combined immunodeficiency (SCID) given transplants of rigorously T cell- depleted HLA-identical or haploidentical relat | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF WASHINGTON | $767,904 | Grant | Trans-NIH Recovery Act Research Support: Salmonella is a highly adapted pathogen that senses and responds to diverse host microenvironments. The regulatory protein SlyA plays a central role in host adaptation by activating key virulence factors that render Salmonella resistant to antimicrobial p | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| CORNELL UNIVERSITY, INC | $817,558 | Grant | Trans-NIH Recovery Act Research Support: Tuberculosis is an extremely successful pathogen with a penetrance of its host population, mankind, that is estimated by WHO to be close to 1/3 of the population of the planet. In areas of high endemnicity for HIV infection, such as Sub-Saharan Africa, t | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| NEW YORK UNIVERSITY (INC) | $845,000 | Grant | Trans-NIH Recovery Act Research Support: Title: Biogenesis of Melanosomes. Melanin protects the skin against ultraviolet radiation-induced damage, thus reducing the risk of cutaneous cancers. Our primary objective is to elucidate the mechanisms that regulate melanin synthesis and characterize t | Health and Human Services, Department of / National Institutes of Health | 8/07/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $850,000 | Grant | Trans-NIH Recovery Act Research Support: SPECIFIC AIM 1: To understand the regulation of PU.1 by transcription factors Aim 1A: We recently demonstrated that there is an 18-fold decrease of functional long term hematopoietic stem cells (LT-HSCs) in mice in which the RUNX1 site in the | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $526,400 | Grant | Trans-NIH Recovery Act Research Support: A strong body of work has implicated the cell surface urokinase receptor (u-PAR) in modulating tumor growth and progression. Elevated u-PAR levels yield increased growth while low u-PAR promotes tumor dormancy the latter protective against microenvironmen | Health and Human Services, Department of / National Institutes of Health | 6/10/2009 |
| COMMONWEALTH MEDICAL COLLEGE, THE | $493,815 | Grant | Trans-NIH Recovery Act Research Support: As breast and ovarian carcinoma progress the tumor cells develop invasive structures, which provide the cells with a mechanism to cross tissue barriers and metastasize. Activation of the tyrosine kinase cSrc is known to occur in breast and ovarian cancers | Health and Human Services, Department of / National Institutes of Health | 8/12/2009 |
| CHILDREN'S RESEARCH INSTITUTE | $768,104 | Grant | Trans-NIH Recovery Act Research Support: Tumor progression, and particularly that of some neuroectodermal tumors (e.g., neuroblastoma and melanoma) causes most cancer-related morbidity and mortality. Thus, understanding and preventing progression is critical to developing effective cancer therap | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $590,240 | Grant | Trans-NIH Recovery Act Research Support: Inference in Regression Models with Missing Covariates: ARRA-funded project. There are two specific aims in this ARRA grant: 1. Frequentist Diagnostic Measures for Regression Models with Missing Data In this aim, We develop frequentist diagnostic measure | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF IOWA, THE | $548,213 | Grant | Trans-NIH Recovery Act Research Support: Tumor suppressor genes (TSGs) elicit carcinogenic phenotypes by gene loss. In thousands of publications, however, TSGs have been assayed for activities by reintroduction into tumor cells with TSG deletions. Whereas the FHIT gene has been defined as a gene | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| CEDARS-SINAI MEDICAL CENTER | $571,328 | Grant | Trans-NIH Recovery Act Research Support: Pituitary tumors account for 15% of intracranial neoplasms and are benign monoclonal neoplasms which may be clinically silent or secrete hormones including prolactin, growth hormone, ACTH, or rarely TSH or gonadotropins. These adenomas account for clinica | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| MAYO CLINIC JACKSONVILLE (A NONPROFIT CORPORATIO | $868,847 | Grant | Trans-NIH Recovery Act Research Support: The long-term goals of this competing renewal are to elucidate protein kinase C (PKC) signaling mechanisms that contribute to cancer and translate these mechanistic insights into better prognostic and treatment strategies. During the current funding perio | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, THE | $641,546 | Grant | Trans-NIH Recovery Act Research Support: B-cell chronic lymphocytic leukemia (CLL), the most common leukemia in the US, is an incurable disease of unknown etiology affecting middle-aged and older individuals. Patients with CLL have variable clinical courses: some live for decades without therap | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $631,497 | Grant | Trans-NIH Recovery Act Research Support: In this proposal we will characterize a member of the family of phorbol ester receptors, protein kinase C epsilon (PKC), and its involvement in prostate carcinogenesis. In the previous funding period we have established that phorbol esters, natural compou | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF ARIZONA | $536,743 | Grant | Trans-NIH Recovery Act Research Support: Natural products have made enormous contributions to human health. The search for new lead compounds from natural sources continues to be a crucial element in modern anticancer drug discovery. Our long-term goal is to discover anticancer drugs that act by | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $620,048 | Grant | Trans-NIH Recovery Act Research Support: Acute; Animals; Autism; Autism, Early Infantile; Autism, Infantile; Autistic Disorder; BDGF; BDNF; BDNF Receptor; BDNF/NT-3 Growth Factors Receptor; Binding; Binding (Molecular Function); Brain; Brain Neoplasia; Brain Neoplasms; Brain Tumors; Brain-Derive | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| MAYO CLINIC | $683,118 | Grant | Trans-NIH Recovery Act Research Support: This study is designed to follow through on unique observations made during our last period of funding which established the importance of p16 in treatment response to photodynamic therapy (PDT). We also showed that PDT was able to eliminate most biomarke | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| BAYLOR COLLEGE OF MEDICINE | $549,624 | Grant | Trans-NIH Recovery Act Research Support: We propose to study the in-depth mechanism of this repression, and how this relates to SAFB1G??s role in breast tumorigenesis. We originally cloned SAFB1 as a transcriptional repressor, and it has since been implicated in a number of processes including | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $621,030 | Grant | Trans-NIH Recovery Act Research Support: Tumor development is a multi-step process that depends upon the successive activation of oncogenes and inactivation of tumor suppressor genes. p53 is mutated in about 50% of human tumors and the p53 protein is known as a guardian of the genome because of | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| BAYLOR COLLEGE OF MEDICINE | $613,439 | Grant | Trans-NIH Recovery Act Research Support: Purpose: To focus on the molecular mechanisms underlying the termination of TGF-? signaling. Abstract: The TGF-? signaling pathway represents a major growth inhibitory pathway in normal epithelial cells, and paradoxically, it promotes proli | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| GEORGIA HEALTH SCIENCES UNIVERSITY RESEARCH INSTITUTE, INC. | $510,370 | Grant | Trans-NIH Recovery Act Research Support: DNA methylation is an essential regulator of transcription, chromatin structure, development, and genomic stability in mammalian cells that is mediated by a family of DNA methyltransferases (DNMTs): DNMT1, DNMT3A, and DNMT3B. While normal patterns are cri | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| WAYNE STATE UNIVERSITY (INC) | $490,704 | Grant | Trans-NIH Recovery Act Research Support: The long-term objective of our research is to augment the efficacy of the cancer treatment photodynamic thearpy (PDT). Three specific aims will test the hypothesis: 1) to demonstrate that cell killing after PDT requires a definitive, enzyme-controlled, S | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $690,000 | Grant | Trans-NIH Recovery Act Research Support: Rats avoid intake of a saccharin conditioned stimulus (CS) when paired with a drug of abuse (LeMagnen, 1969; for reviews, see Gamzu, Vincent, & Boff, 1985; Goudie, 1987; Hunt & Amit, 1987). For decades, the suppressive effects of drugs of abuse on CS inta | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $715,263 | Grant | Trans-NIH Recovery Act Research Support: Award Title: Stress Responses, Psychosocial Stress and Pain Perception in African Americans. The overall purpose of this study is examine the role of psychosocial stress exposure and stress reactivity (cardiovascular and neuroendocrine) in influencing | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | $463,500 | Grant | Trans-NIH Recovery Act Research Support: These experiments focus on the neurobiological mediators of motivation to seek offspring versus cocaine during the postpartum period, a unique period in the life of the female, critical for the survival of her offspring. A foremost goal of my preclinical | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| THE VANDERBILT UNIVERSITY | $774,457 | Grant | Trans-NIH Recovery Act Research Support: The long-term objective of this project is to understand how changes in insulin signaling regulate the actions of amphetamine (AMPH). Dopamine (DA) transporters (DATs), which largely control DA clearance, are targets for psychostimulants such as AMPH and | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE | $616,000 | Grant | Trans-NIH Recovery Act Research Support: When amphetamine is repeatedly associated with the same environmental context, the environment becomes a powerful stimulus to elicit memories of the drug experience. These memories bring out a strong, physiological response, even in the absence of drug. S | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $1,369,510 | Grant | Trans-NIH Recovery Act Research Support: Hearing plays an important role in the normal development of brain structure and function. Previous work supported by this grant has shown that hereditary congenital deafness in cats results in abnormal synaptic structure in auditory nerve terminals, and | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| WASHINGTON UNIVERSITY, THE | $760,000 | Grant | Trans-NIH Recovery Act Research Support: The loss of sensory hair cells from the human ear is a leading cause of hearing and balance disorders. Although the potential for regeneration in the human ear is very limited, the ears of nonmammalian vertebrates can quickly regenerate after injury. A de | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $410,002 | Grant | Trans-NIH Recovery Act Research Support: This award will be used to study the intestinal pathology caused by shiga toxin producing strains of E. coli bacteria with overall goal to develop new approaches to treat shiga toxin-induced intestinal and systemic diseases. Intestinal pathology caused by | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF OKLAHOMA | $355,263 | Grant | Trans-NIH Recovery Act Research Support: The broad goal of this application is to understand the mechanisms by which RNA binding protein CUGBP2 regulates gene expression at the posttranscriptional level of mRNA stability and translation in intestinal epithelial cells. Overexpression of the prote | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF PITTSBURGH THE | $738,154 | Grant | Trans-NIH Recovery Act Research Support: This was originally a 5-year grant proposal (competing renewal) to determine whether a renal extracellular 2',3'-cAMP-adenosine pathway exists, whether it is mediated by ecto-enzymes that are different from those mediating the 3',5'-cAMP-adenosine pathway | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE | $751,878 | Grant | Trans-NIH Recovery Act Research Support: The aims of the supplement 2 R01DK080480-19A2 for the parent grant titled 'Neural Control of the Gallbladder' involve an integrated approach using state-of-the-art techniques to investigate gallbladder pathophysiology from single molecules to the intact | Health and Human Services, Department of / National Institutes of Health | 8/25/2009 |
| THE VANDERBILT UNIVERSITY | $729,352 | Grant | Trans-NIH Recovery Act Research Support: The overarching aim of this project is to quantitatively characterize sub-voxel models of tissue water by nuclear magnetic resonance (NMR) for the broader purpose of improving diagnostic specificity of magnetic resonance imaging (MRI) protocols. A fundame | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| UNIVERSITY OF ARIZONA | $766,617 | Grant | Trans-NIH Recovery Act Research Support: Females are born with a finite pool of primordial follicle which, once depleted, cannot be replaced. Exposure to environmental chemicals can cause depletion of this pool, leading to premature ovarian failure, or early menopause. A variety of health disord | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $648,475 | Grant | Trans-NIH Recovery Act Research Support: Metabolism and Toxicity of Arsenic in the Human Liver-ARRA Inorganic arsenic (iAs) is a potent environmental toxin and carcinogen. The susceptibility to toxic and carcinogenic effects of chronic exposures to iAs varies significantly among individuals. | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $759,697 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this ongoing research program is to understand the molecular basis of cell-cell interactions that regulate retinal neurogenesis during development and regeneration. The zebrafish (Danio rerio) provides a powerful genetic model in which | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| DOHENY EYE INSTITUTE | $815,000 | Grant | Trans-NIH Recovery Act Research Support: Title: Mechanism of Retrocorneal Fibrous Membrane Description: During abnormal wound healing, corneal endothelium (the inner layer of the cornea) is transformed into fibroblasts which produce scar tissue (fibrosis) in the otherwise transparent cornea. | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) | $692,480 | Grant | Trans-NIH Recovery Act Research Support: It is well recognized that the photoreceptor synaptic terminal responds to injury and disease by making structural changes. In retinal detachment the rod axon retracts toward the cell body, thereby uncoupling the first synapse in the visual pathway, wher | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| BAYLOR COLLEGE OF MEDICINE | $1,156,554 | Grant | Trans-NIH Recovery Act Research Support: PURPOSE: The goal of this project is to determine the developmental fate and gene expression of the head surface ectoderm in the absence of the retina. Identification of these genes and developmental processes will lead to the better understanding of eye | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $981,254 | Grant | Trans-NIH Recovery Act Research Support: Clinical, pathologic, and experimental studies support an important role for the macrophage in a broad spectrum of acute (e.g. pathogen infection, sepsis) and chronic inflammatory conditions (e.g. insulin resistance, atherosclerosis and tumorigenesis). Re | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $910,983 | Grant | Trans-NIH Recovery Act Research Support: Following myocardial infarction, the mechanical properties of the healing scar are a critical determinant of left ventricular function, infarct expansion, aneurysm formation and rupture, and ventricular remodeling. Until recently, the only therapeutic opt | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $767,551 | Grant | Trans-NIH Recovery Act Research Support: The goal of this revised application is to study the relationships between intracellular Ca (Cai) dynamics and the mechanisms of ventricular fibrillation (VF) and defibrillation. In the present funding period, we discovered that Cai dynamics and spontaneo | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $1,279,003 | Grant | Trans-NIH Recovery Act Research Support: c-FLIP is a key anti-apoptotic factor that is over-expressed in many tumors and blocks the apoptotic machinery by interfering with FADD, caspase-8 and DR5. Significant evidence demonstrates that c-FLIP over-expression in tumors is a major cause of resista | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF WASHINGTON | $1,144,277 | Grant | Trans-NIH Recovery Act Research Support: Examination of atherosclerotic lesions from humans and animal models has established a central role for macrophages in disease progression and plaque disruption. Despite these observations, it is still unclear what changes within the lesions result in pla | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | $688,492 | Grant | Trans-NIH Recovery Act Research Support: Our work and that others has established the existence of a robust correlation between loss of neuronal cell cycle control and cell death. Experimental evidence suggests that that blockade of the cycle is effective at blocking neuronal cell death, and we | Health and Human Services, Department of / National Institutes of Health | 7/24/2009 |
| THOMAS JEFFERSON UNIVERSITY | $760,510 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this project is to shed light on the molecular mechanisms that govern the function and regulation of the neuronal somatodendritic A-type potassium current (Isa). Typically, Isa operates in the subthreshold range of membrance potentia | Health and Human Services, Department of / National Institutes of Health | 6/15/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $750,000 | Grant | Trans-NIH Recovery Act Research Support: Experimental autoimmune encephalomyelitis (EAE) is a T cell mediated, autoimmune disorder characterized by central nervous system (CNS) inflammation and demyelination, features reminiscent of the human disease, multiple sclerosis (MS). Prior work in the E | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $573,629 | Grant | Trans-NIH Recovery Act Research Support: The potential role of extracellular proteases, namely the plasminogen activator/ plasminogen (PA/plgn) system in synaptic remodeling in the injured spinal cord of rodents will be the focus of these studies. The PA/plgn system has been suggested to play a | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $854,550 | Grant | Trans-NIH Recovery Act Research Support: Transcriptional dysregulation has emerged as a central pathogenic mechanism in Huntington's disease (HO), which is associated with neuropathological changes predominantly in the striatum. Accordingly, mRNAs of genes showing enriched expression in the stri | Health and Human Services, Department of / National Institutes of Health | 7/27/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $770,000 | Grant | Trans-NIH Recovery Act Research Support: Temporal lobe epilepsy (TLE) is a common form of medically refractory epilepsy characterized by recurrent unprovoked seizures involving the limbic structures, which often requires surgery. Multiple pathophysiological mechanisms have been proposed to expla | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| GEORGIA TECH RESEARCH CORPORATION | $764,733 | Grant | Trans-NIH Recovery Act Research Support: Severe traumatic injuries and invasive surgical procedures such as tumor resection often create peripheral nerve gaps, accounting for 200,000 injuries in the US annually. The clinical gold standard for bridging peripheral nerve gaps is autografts (typical | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| VIRGINIA COMMONWEALTH UNIVERSITY | $801,648 | Grant | Trans-NIH Recovery Act Research Support: This competitive renewal seeks to continue its exploration of that neuronal somatic damage and death triggered by a diffuse traumatic brain injury (TBI) uncomplicated by contusion or mass lesion formation. Although previous studies considering apoptotic | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $795,465 | Grant | Trans-NIH Recovery Act Research Support: This award funds basic research in neurobiology to understand how the brain develops. Results have implications for understanding and preventing neurodevelopmental disorders. The work focuses on an important process in late stages of development of cere | Health and Human Services, Department of / National Institutes of Health | 8/19/2009 |
| HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY M | $274,742 | Grant | Trans-NIH Recovery Act Research Support: Gonorrhea is the second most frequently reported infection to the CDC and a major cause of pelvic inflammatory disease and the complications of ectopic pregnancy, infertility and chronic pelvic pain. There is no gonorrhea vaccine and antibiotic resistance | Health and Human Services, Department of / National Institutes of Health | 9/26/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $186,714 | Grant | Trans-NIH Recovery Act Research Support: This grant is focused on identifying and understanding the regulation of sub-telomeric virulence genes in C. glabrata. There are three sub-aims: 1) Sub-telomeres consist of regions repeated between different telomeres. In the current public database the s | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $414,786 | Grant | Trans-NIH Recovery Act Research Support: This project is in the area of reproductive immunology, i.e. the immunological interaction between maternal and fetal tissues. Its goal is to understand maternal-fetal tolerance, i.e. the lack of maternal rejection of the fetus that carries foreign patern | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| NEW YORK UNIVERSITY (INC) | $211,250 | Grant | Trans-NIH Recovery Act Research Support: Nuclear hormone receptors (NRs) modulate transcription through interaction with co-activators and corepressors which leads to chromatin modifications involving histone acetylation and methylation. In addition to the DRIP/TRAP G?MediatorG? and the p160/SRC | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $1,204,139 | Grant | Trans-NIH Recovery Act Research Support: Consistent with their roles in mediating neuronal inhibition, deficits in GABA(B) receptor function play significant roles in both neurological and psychiatric disorders that include ischemia, epilepsy, schizophrenia, addiction, and nociception. Given th | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| UNIVERSITY OF CHICAGO, THE | $402,605 | Grant | Trans-NIH Recovery Act Research Support: Developmental defects of the cerebellum in humans have received less attention than other brainmalformations such as neural tube defects and cortical malformations. Yet, cerebellar malformations arecommon, affecting approximately 1/5000 births. Dandy-Walk | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $718,169 | Grant | Trans-NIH Recovery Act Research Support: Clinical trials of a new treatment may proceed through three phases. Phase I trials are small studies that evaluate toxicity with a specific task to determine the maximum tolerated dose. Once a safe dose of the treatment is chosen, its therapeutic efficac | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF ALABAMA IN HUNTSVILLE | $220,900 | Grant | Trans-NIH Recovery Act Research Support: We are interested in understanding protein-ligand interactions and the microevolutionary processes that permit and promote changes at the protein-ligand interface. To explore these issues, we are studying the Phd repressor/antitoxin and selected homologs. | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| MIAMI UNIVERSITY | $213,000 | Grant | Trans-NIH Recovery Act Research Support: The underlying hypothesis of the present study is that neurotrophins regulate the survival of peripheral neurons. Unraveling the complex mechanisms regulating neurotrophin expression is critical to the understanding of neuronal survival, aging, and neurod | Health and Human Services, Department of / National Institutes of Health | 5/01/2009 |
| NOVADIGM THERAPEUTICS, INC. | $1,989,750 | Grant | Trans-NIH Recovery Act Research Support: Our Specific Aims are: 1. To establish Good Manufacturing Practice for the rAls3p-N vaccine candidate. GMP will be established by a contracting organization. Financing for GMP will occur over two calendar years. The GMP process will include technologic | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| PIXEL VELOCITY INCORPORATED | $664,541 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of the proposed research program is to design and develop a noninvasive device for accurately measuring arterial compliance. Arterial compliance has been shown to be a strong indicator of many types of vascular disease, including cardiova | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| RADIATION MONITORING DEVICES, INC. | $1,318,815 | Grant | Trans-NIH Recovery Act Research Support: SBIR Award | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| UNIVERSITY OF SOUTH FLORIDA | $76,637 | Grant | Trans-NIH Recovery Act Research Support: A variety of different mechanisms to combat pathogen challenges have emered during metazoan evolution. The diverse nature of form, funciton and phylogenetic integration of these processes is significant for understanding basic mechanisms governing immune | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| BAYLOR COLLEGE OF MEDICINE | $383,750 | Grant | Trans-NIH Recovery Act Research Support: Purpose. To elucidate molecular mechanisms involved in HIV Tat function. Abstract: The HIV-1 Tat protein is essential for viral replication and it acts to activate RNA polymerase II (RNAP II) elongation of the integrated provirus. To a considerable ext | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| CALIFORNIA STATE UNIVERSITY AUXILIARY SERVICES, INC | $150,549 | Grant | Trans-NIH Recovery Act Research Support: Body weight supported treadmill (BWST) training has been used successfully to improve locomotor function in people following spinal cord injury and stroke. Sophisticated robotic gait training systems have been developed to facilitate BWST training, howeve | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $241,049 | Grant | Trans-NIH Recovery Act Research Support: Award title: Analysis of the Cell Biological Mechanisms of Learning and Memory in a Simple Model Invertebrate System. Perhaps the most basic form of associative learning, classical conditioning has been the subject of scientific investigation for a centur | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC. | $589,613 | Grant | Trans-NIH Recovery Act Research Support: The primary goal of this Program Project is to use a synergistic combination of genomics, molecular genetics and natural products chemistry to identify and purify potentially useful secondary metabolites of the filamentous fungus Aspergillus nidulans. The | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| YALE UNIVERSITY | $296,930 | Grant | Trans-NIH Recovery Act Research Support: This application is in response to NIH Notice NOT-OD-09-056 for supplemental support for the Yale Liver Center P30-34989, an NIDDK Digestive Disease Center grant. This Supplement will advance the objectives of the ARRA by 1) Accelerating the pace of scien | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $43,327 | Grant | Trans-NIH Recovery Act Research Support: Funds to purchase equipment for electrophysiology experiments on neurons in brain slices and in culture with the goal of understanding plastic changes in the brain involving GABA-A receptors following acute and chronic administration of alcohol to rats, p | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $214,386 | Grant | Trans-NIH Recovery Act Research Support: Award title: Regulation of sarcopenia and muscle dysfunction by nitric oxide. Sarcopenia, the loss of muscle mass during aging, is an inevitable consequence of aging that takes a tremendous toll on the quality of life of the elderly, and predisposes the | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF MASSACHUSETTS | $262,800 | Grant | Trans-NIH Recovery Act Research Support: Recent work in our lab identified NKG2D-NKG2D ligand (Rae-1)- mediated interactions between activated NK cells and T cells and PyV-induced tumor cells, and our data suggest that these interactions may play an important role in the resistance to PyV-induce | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| THE CHILDRENS HOSPITAL LOS ANGELES | $492,085 | Grant | Trans-NIH Recovery Act Research Support: This research is proposed under Notice Number NOT-OD-09-058 G?NIH announces the availability of recovery act funds for Competitive Revision applicationsG?. Despite substantial advances in the treatment of acute lymphoblastic leukemia (ALL), the rate of lo | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| THOMAS JEFFERSON UNIVERSITY | $148,739 | Grant | Trans-NIH Recovery Act Research Support: This Administrative Supplement has the direct goal of employing two research technicians, preferentially recent graduates with Masters degrees or equivalent, to facilitate important progress on Aim 3 of the parental grant. Their focus will specifically b | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY, THE | $101,430 | Grant | Trans-NIH Recovery Act Research Support: Randomized Clinical Trial of a Less-Invasive Resuscitation Protocol for Sepsis The research program in this award seeks to test the hypothesis that a less- invasive goal-directed resuscitation protocol is equivalent to a fully invasive goal-directed resu | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $7,126 | Grant | Trans-NIH Recovery Act Research Support: Title: Learning How to Keep TABS (Talking About BMI Screening) ARRA Description of the ARRA-funded project: The background of the parent grant is that neither parents nor pediatricians appropriately recognize children's weight status, impeding early inter | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC. | $108,000 | Grant | Trans-NIH Recovery Act Research Support: The specific aim of this supplement is to examine the relationship of aerobic fitness with longitudinal changes in neuroimaging biomarkers utilizing existing data collected as part of the K23 efforts. Specifically, we will assess the relationship between | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| BOSTON MEDICAL CENTER CORPORATION | $71,654 | Grant | Trans-NIH Recovery Act Research Support: To hire a research assistant to recruit and enroll subjects 107+ age group. People age 107+ years are both extremely rare and phenotypically similar such that demographic selection has likely made such a group of subjects a powerful sample for the discov | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | $51,955 | Grant | Trans-NIH Recovery Act Research Support: Gastric dysmotility is relevant in several clinical disorders including gastroparesis and functional dyspepsia. This grant reflects the PI?s long-term research objectives to advance the evaluation and treatment of gastric motility disorders through a bet | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $54,000 | Grant | Trans-NIH Recovery Act Research Support: I am a German MD/Ph.D. clinician-scientist with extensive training in Internal Medicine and Nephrology at Johns Hopkins and Harvard. My research focuses on the epidermal growth factor receptor (EGFR) signaling pathway. In my earlier work I discovered that | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $200,521 | Grant | Trans-NIH Recovery Act Research Support: Award issued effective 09/30/2009. The goals of this supplement are to: 1) Develop and execute a flow cytometry based assay to confirm hits identified by a high throughput screen from our collaborators at the NIH Chemical Genomics Center. These hits are | Health and Human Services, Department of / National Institutes of Health | 9/20/2009 |
| ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE | $93,125 | Grant | Trans-NIH Recovery Act Research Support: Krabbe's disease is a life threatening, inherited glycogen storage disease resulting from mutations in the enzyme galactocerebrosidase (GALC). The only available therapy is heterologous bone marrow transplantation during the earliest months of life to pro | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $17,604 | Grant | Trans-NIH Recovery Act Research Support: This grant provided a summer research experience for one college student in health related scientific research. | Health and Human Services, Department of / National Institutes of Health | 7/27/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $895,945 | Grant | Trans-NIH Recovery Act Research Support: ImmGen is a collaborative group of 12 Immunology and Computational Biology laboratories, whose goal is to decipher genome-wide patterns of gene expression and regulatory networks across the entire murine immune system. This effort, supported by Resource g | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF HAWAII SYSTEMS | $600,000 | Grant | Trans-NIH Recovery Act Research Support: Obesity and overweight are well recognized public health concerns in the US and the magnitude of excess weight is greater among racial/ethnic minority populations. For Native Hawaiians (NHs) and Pacific Peoples (PPs) 70 to 80% of adults are estimated to b | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $364,660 | Grant | Trans-NIH Recovery Act Research Support: This R01 supplement will focus and elaborate on the scientific objective of the parent grant, `Suppression of pathogenic autoantibodies in lupus by inhibition of Activation Induced Cytidine Deaminase, to understand how IL-17 promotes development of autore | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| NORTHWESTERN UNIVERSITY | $281,225 | Grant | Trans-NIH Recovery Act Research Support: This supplement will create a new senior post-doctoral position for a first year fellow. This is appropriate for ARRA in creating jobs and increasing the tempo of CRS research. | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| MISSOURI SYSTEM, UNIVERSITY OF | $57,122 | Grant | Trans-NIH Recovery Act Research Support: We request an administrative supplement to hire new personnel critical to accelerating the pace of our NIH-funded project to study RNA aptamer inhibitors of HIV-1 Reverse Transcriptase (RT). The supplement will support formation of a team of three undergr | Health and Human Services, Department of / National Institutes of Health | 7/10/2009 |
| OREGON STATE UNIVERSITY | $78,621 | Grant | Trans-NIH Recovery Act Research Support: Circadian clocks are evolutionary conserved coordinators of behavioral and physiological processes. Malfunctions of circadian clocks in humans lead to serious pathologies such as sleep disorders and cancer. Circadian timekeeping is accomplished by molecul | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | $214,033 | Grant | Trans-NIH Recovery Act Research Support: SecA is a highly conserved and essential helicase-like motor protein of the bacterial Sec translocase machinery. SecA recognizes secretory proteins and couples their transport through the transmembrane SecYEG channel with the expenditure of metabolic ener | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) | $108,497 | Grant | Trans-NIH Recovery Act Research Support: Eukaryotic cells respond to DNA damage by activating checkpoint pathways conserved from yeast to human. Failure in proper activation of the checkpoint response has been implicated as a major cause of chromosomal instability, which leads to cancer in highe | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| KANSAS STATE UNIVERSITY | $80,136 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Epithelia acts as barriers to the movement of small molecules, including ions and drugs, between body compartments. Ions cross the epithelial apical and basolateral membranes via tightly regulated ion-specific transpor | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $314,000 | Grant | Trans-NIH Recovery Act Research Support: This award was made to fund two pilot projects for two years at $50,000 a year. These pilots will advance our understanding of the role of role of hypoxia in the etiology, pathogenesis, and treatment of cancer and the growth and migration of cancer stem | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $49,023 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The University of Michigan Comprehensive Cancer Center (UMCCC) requests renewal of its core grant in support of Senior Leadership, Programs, and Shared Core Facilities. A core grant to support the UMCCC was initially a | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| GEORGETOWN UNIVERSITY (THE) | $45,878 | Grant | Trans-NIH Recovery Act Research Support: Once women enter menopause, they lose their protection from hypertension, cardiovascular disease and progressive renal disease when compared to age-matched premenopausal women and age-matched men. In the first funding period, we found that experimentally | Health and Human Services, Department of / National Institutes of Health | 8/05/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $166,618 | Grant | Trans-NIH Recovery Act Research Support: A neuropathological hallmark in Alzheimer disease (AD) and related disorders is the neurofibrillary tangles, whose main component is hyperphosphorylated tau, a microtubule-binding protein. The formation of the tangles in AD has been shown to be preceded b | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| PALO ALTO INSTITUTE FOR RESEARCH AND EDUCATION, INC. | $285,638 | Grant | Trans-NIH Recovery Act Research Support: To accelerate the rate of progress on the parent grant (R01 AG028867; Molecular Mechanisms of Mammalian SIRT6 Function), we request funds to (1) create a new job to hire a new Post-doctoral Fellow; (2) retain a Research Assistant/Lab Manager who may other | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| GEORGETOWN UNIVERSITY (THE) | $224,573 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this supplement is to determine whether milder levels of hyponatremia, as typically seen in the majority of human patients (serum [Na+] = 125-134 mEq/L), causes bone loss leading to osteoporosis as we have previously reported in our animal | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| CALIFORNIA INSTITUTE OF TECHNOLOGY | $16,125 | Grant | Trans-NIH Recovery Act Research Support: This grant provides a summer research experience for 1 undergraduate student in health-related scientific research. | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| UNIVERSITY OF CHICAGO, THE | $75,000 | Grant | Trans-NIH Recovery Act Research Support: The longitudinal study of the CHASRS sample began in 2002 with a population-based sample of 229 adults 50 to 67 years old. We have been accumulating broad and richly deep data to optimally address how psychosocial factors, especially objective and perceiv | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $85,576 | Grant | Trans-NIH Recovery Act Research Support: Influenza A and B viruses cause a highly contagious respiratory disease in humans. Influenza B viruses infect only humans, whereas influenza A viruses infect many avian and mammalian species. Influenza A viruses are responsible for the periodic wide-sprea | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $32,213 | Grant | Trans-NIH Recovery Act Research Support: Attraction of students to scientific research is a central element in maintaining the quality of and quantity of science in the United States. College students have reached a level of knowledge and skill and have begun to consider their career plans so th | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $66,451 | Grant | Trans-NIH Recovery Act Research Support: In 2009, this grant provided summer research experiences for 2 college students (Ms. Huili Zhu and Ms. Komal Kothari) in health-related scientific research. Ms. Huili developed an ELISA assay to assess CD16b (an Fc gamma receptor found in neutrophils) an | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| MOREHOUSE SCHOOL OF MEDICINE, INC., THE | $573,566 | Grant | Trans-NIH Recovery Act Research Support: This project funds a career development program for junior faculty that would provide mentoring opportunities for researchers in the area of cancer prevention and control and the translation of new knowledge into the community. This would build on the str | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF ARKANSAS SYSTEM | $531,565 | Grant | Trans-NIH Recovery Act Research Support: To make a positive impact on health disparities, strong partnerships are needed to foster programs that cultivate collaborative relationships among diverse groups, including decision-makers, community members, researchers, and other stakeholders. It is al | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $50,001 | Grant | Trans-NIH Recovery Act Research Support: Administrative supplements are available to NCI-Designated Comprehensive and Clinical Cancer Centers for participation in the new initiative entitled ADOPTion of New Technologies for Remote Data Capture and Protocol Authoring (ADOPT), which is intended to | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $42,250 | Grant | Trans-NIH Recovery Act Research Support: Project is to improve the computational infrastructure of the comparative genomics resource, Roundup to speed queries and enable broader coverage of existing fully sequenced genomes. | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF NEBRASKA | $23,760 | Grant | Trans-NIH Recovery Act Research Support: The overall objective of the funding received from this supplement to my NIH-funded research grant is to bring undergraduate biology students or other students in other scientific curricula to my laboratory or colleagues laboratories for a summer research | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| TRUDEAU INSTITUTE INC | $12,460 | Grant | Trans-NIH Recovery Act Research Support: The goals of this supplemental project are straightforward and utilize established experimental methods for studying the influence of age on CD4 T cell function presented in detail in the parent R37 proposal. The Research Design and Methods section of th | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| YALE UNIVERSITY | $100,000 | Grant | Trans-NIH Recovery Act Research Support: Bile secretion is a major function of the liver which is frequently impaired in diseases of the liver resulting in the syndrome of cholestasis. The long term objectives of this grant application, funded continuously since 1973, have been to characterize t | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| RFCUNY - HUNTER COLLEGE | $298,604 | Grant | Trans-NIH Recovery Act Research Support: Research Centers in Minority Institutions Award: To assist predominantly minority institutions that offer the doctorate in the health professions and/or health-related sciences in strengthening and augmenting their human and physical resources for the con | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| RFCUNY - HUNTER COLLEGE | $299,668 | Grant | Trans-NIH Recovery Act Research Support: NCRR/RCMI/ARRA supplement Award: Three outstanding young scientists, including two minorities, worked to contribute to the scientific workforce of the future, and to serve as role models for science collaboration and dissemination of scientific informat | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF HAWAII SYSTEMS | $880,333 | Grant | Trans-NIH Recovery Act Research Support: As the principal U.S. institution of higher education engaged in biomedical and bio-behavioral research within the Pacific basin, the University of Hawaii at Manoa (UHM) seeks continued support from the Research Centers in Minority Institutions (RCMI) Pro | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $49,753 | Grant | Trans-NIH Recovery Act Research Support: ADOPTion of New Technologies for Remote Data Capture and Protocol Authoring The purpose is to have University of North Carolina's Lineberger Cancer Center participate in NCI's project ADOPT. | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $308,000 | Grant | Trans-NIH Recovery Act Research Support: The University of Texas M. D. Anderson Cancer Center (MDACC) is a free-standing comprehensive cancer center within the University of Texas system. The mission of the MDACC is to eliminate cancer in Texas, the nation and the world through outstanding integ | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $49,805 | Grant | Trans-NIH Recovery Act Research Support: CALCIUM SENSING RECEPTOR SIGNALING IN THE GASTROINTESTINAL TRACK A rise in the concentration of intracellular free calcium ([Ca2+]i) is a key signal in the initiation of a wide variety of biological processes including cell proliferation and differentiat | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF MASSACHUSETTS | $180,226 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to develop a new set of molecular reagents that specifically deliver molecular probes to the individual subunits of functioning K+ channel complexes. The development of this novel technology will enable the facile determination | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $200,973 | Grant | Trans-NIH Recovery Act Research Support: A proposal to determine if expression of the COX-2 gene in specific cells is sufficient to render mice subject to chemically induced skin cancer. In the parent application for this supplement, R01CA123055, we described specific aims to determine (i) in wh | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $400,696 | Grant | Trans-NIH Recovery Act Research Support: Nell-1, a cause of excessive bone growth in craniosynostosis patients has shown significant promise as a potent bone forming agent in preclinical studies. A better understanding of how and why Nell-1 works to form bone can accelerate the development of cl | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $87,407 | Grant | Trans-NIH Recovery Act Research Support: The goal of this Project is to understand the molecular mechanism of sugar and salt absorption across the small intestine. Specifically, to determine how Na and glucose are transported across the brush border membrane of enterocytes by the Na/glucose cotr | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $93,433 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement was provided to hire a technician responsible for performing assay, in vitro cell culture experiments, and maintaining cell lines. The technician works full time in the bone histology and biology lab and who has been instrum | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| THOMAS JEFFERSON UNIVERSITY | $178,063 | Grant | Trans-NIH Recovery Act Research Support: Liver injury due to prescription and non-prescription medication use is an important public health problem. Drug-induced liver injury (DILI) is the most common reason for adverse actions taken on drugs by the Food and Drug Administration. Detection of DIL | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $158,740 | Grant | Trans-NIH Recovery Act Research Support: Supplement experiments are using conical electron tomography, density segmentation and quantitative statistical approaches to evaluate horizontal cell endings. There are two types of endings, axonal which end in rod spherules and dendritic which end in c | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| UNIVERSITY OF LOUISVILLE | $9,472 | Grant | Trans-NIH Recovery Act Research Support: Student receives training that may influence a decision to pursue a degree in biomedical research. | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| YALE UNIVERSITY | $160,295 | Grant | Trans-NIH Recovery Act Research Support: Symbiotic microbial relations are extremely pervasive, with examples being found among all levels of the earth's biota. These associations vary with regard to their interactive nature, and are characterized by the benefit (or detriment) imparted to the pa | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| YALE UNIVERSITY | $42,430 | Grant | Trans-NIH Recovery Act Research Support: Efforts to be supported by the supplemental request will focus on measuring the effects of myosins V, VI and VII on allosteric actin filament bending dynamics. Cooperative binding to actin filaments, mediated through myosin-dependent long-range conformati | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $322,209 | Grant | Trans-NIH Recovery Act Research Support: The long term objective of the parent grant is to define the molecular mechanism of clathrin coated vesicle formation, a fundamental process in eukaryotic cells. Defects in ccv formation are associated with a number of diseases including heart disease, c | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $166,764 | Grant | Trans-NIH Recovery Act Research Support: Functional Roles of Coenzyme Q in Yeast and Human Cells Coenzyme Q (ubiquinone or Q) functions in cells as a redox-active coenzyme of mitochondrial and plasma membrane electron transport, as well as an essential lipid soluble antioxidant. Dietary suppleme | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $112,001 | Grant | Trans-NIH Recovery Act Research Support: This project aims both to elucidate the mechanisms controlling changes in alternative splicing in mammalian cells and to understand the role of this splicing regulation in neural development. The first two specific aims are 1. Characterize the mechanism | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $197,955 | Grant | Trans-NIH Recovery Act Research Support: The biosynthesis of glycosylphosphatidylinositol (GPI)-anchored proteins (such as the folate receptor, prion protein, and the neural cell adhesion molecule (NCAM)) is critical for normal cell growth, and perturbed in human cancers as well as a number of g | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $172,523 | Grant | Trans-NIH Recovery Act Research Support: A photobiological and functional genomics study to elucidate the functional interactions of different photoreceptor signaling pathways. How organisms respond to light and how photosensory receptors mediate light responses are some of the most basic questi | Health and Human Services, Department of / National Institutes of Health | 9/10/2010 |
| UNIVERSITY OF NEBRASKA | $89,605 | Grant | Trans-NIH Recovery Act Research Support: Within our cells, there are immune system receptors that capture fragments from viruses (if the cell is infected with a virus, such as influenza), or capture fragments from abnormal proteins if the cell is a cancer cell. These receptors then show these f | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| UNIVERSITY OF ARKANSAS SYSTEM | $50,000 | Grant | Trans-NIH Recovery Act Research Support: The bacterial cell wall plays a fundamental role in several critical biological processes, including protecting microorganisms against lysis by osmotic pressure and contributing to subcellular organization and overall morphology. The wall also creates pol | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF NEBRASKA | $212,273 | Grant | Trans-NIH Recovery Act Research Support: Endocytic recycling is essential for the control of receptors on the plasma membrane in mammalian cells. Consequently, recycling impacts health by regulating crucial cellular events such as signal transduction and proliferation, cholesterol homeostasis, n | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| IOWA STATE UNIVERSITY | $52,007 | Grant | Trans-NIH Recovery Act Research Support: High-Accuracy Protein Models Derived from Lower Resolution Data The main scope of the Parent Grant R01 GM0816830 G?High-Accuracy Protein Models Derived from Lower Resolution Data is to improve existing comparative (homology) modeling, fold recognition an | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF ARKANSAS SYSTEM | $244,993 | Grant | Trans-NIH Recovery Act Research Support: Supplement to Biochemistry of recombination in gametogenesis. This is an administrative supplement for an ongoing research project (R01 GM81766). The supplement is to support research within the general scope of the peer-reviewed activities and aims app | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| UNIVERSITY OF TENNESSEE | $27,790 | Grant | Trans-NIH Recovery Act Research Support: Previous studies from our laboratory and those from other investigators have shown that prostanoids generated in cerebral blood vessels contribute to cerebral vasodilation produced by hypotension. Recently, we reported that arachidonic acid (AA)-induced | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $19,829 | Grant | Trans-NIH Recovery Act Research Support: Drosophila melanogaster has been acknowledged as a premier genetic model system for understanding gene function, developmental networks and molecular basis for genetic disorders including cancers. Drosophila has blood cells or hemocytes that are important | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $288,456 | Grant | Trans-NIH Recovery Act Research Support: ADMINISTRATIVE SUPPLEMENT NOT-OD-09-056 FOR - The Role of Chemokines During Lung Allograft Dysfunction (1R01HL080206) Lung transplantation is a therapeutic option for a number of end-stage pulmonary disorders. Unfortunately, lung allograft dysfunction is | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $234,126 | Grant | Trans-NIH Recovery Act Research Support: TitleG??New therapeutic approaches for hutchinson-gilford progeria syndrome Understanding how defective processing of prelamin A, the precursor to the nuclear lamina structural protein lamin A, leads to disease. Overall purposeG??The purpose of this admin | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| YALE UNIVERSITY | $34,077 | Grant | Trans-NIH Recovery Act Research Support: Tourette's Syndrome (TS) is a childhood-onset neuropsychiatric illness characterized by motor and vocal tics. The cerebral cortex-basal ganglia circuitry regulates motor habits and goal-directed behavior. A question still unanswered is whether there are c | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $133,672 | Grant | Trans-NIH Recovery Act Research Support: The goal of the parent R01 (NS41574) is to understand the mechanisms that lead to neuronal dysfunction in HuntingtonG??s disease (HD), an inherited, progressive neurological disorder characterized by abnormal dance-like movements (chorea), cognitive distu | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| YALE UNIVERSITY | $87,028 | Grant | Trans-NIH Recovery Act Research Support: Support is requested to continue what has proven to be a highly successful program for the training of predoctoral students at the interface of chemistry and biology. Over the past four years, this CBI training program has supported 20 graduate students, | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $111,201 | Grant | Trans-NIH Recovery Act Research Support: This ARRA administrative supplement to an NIMH T32 Grant focuses on providing one additional year of postdoctoral research training support to two postdoctoral research fellows whose planned postdoctoral training period would have ended prematurely withou | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $105,045 | Grant | Trans-NIH Recovery Act Research Support: This Administrative Supplement Proposal expanded by one position our existing Institutional National Research Service Award (T32). Our T32 Program is unique at UCLA and in Southern California due to its theme: providing research training to postdoctoral l | Health and Human Services, Department of / National Institutes of Health | 7/24/2009 |
| MEDICAL COLLEGE OF WISCONSIN, INC., THE | $383,449 | Grant | Trans-NIH Recovery Act Research Support: Pandemic influenza and infectious agents of bioterrorism (CDC category A agents) continue to remain significant threats to public health and are prioritized as critically important areas of research. Our laboratory received a 5 year grant for the developm | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |