Listing all stimulus spending by amount, in descending order. Return to National Institutes of Health page
Amount refers to both the amount of stimulus funding going toward the project and the face value of the loan.
| Recipient | Amount | Type | Description | Federal Dept./Agency | Date |
|---|---|---|---|---|---|
| YALE UNIVERSITY | $65,980 | Grant | Trans-NIH Recovery Act Research Support: In order to understand the potential selective forces that control codon usage in a model eukaryote, Drosophila, we propose to develop a direct experimental approach that has the potential or elucidating at what stage the phenotypic differences among DNA | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| YALE UNIVERSITY | $288,402 | Grant | Trans-NIH Recovery Act Research Support: Exocytosis is a fundamental cell biological process in all eukaryotic cells, through which intracellular molecules are secreted and the levels of membrane proteins and lipids are regulated. The work proposed here focuses on the exocyst, a multimeric, ~800 | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| YALE UNIVERSITY | $166,733 | Grant | Trans-NIH Recovery Act Research Support: Endothelial cells (EC) in the heart play a variety of important roles both during development and in the adult animal. Cardiac EC are uniquely poised to act as sensors of systemic stress (by virtue of exposure to circulating factors) as well as sensors an | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF ARKANSAS SYSTEM | $6,496 | Grant | Trans-NIH Recovery Act Research Support: Hypertension or high blood pressure is a disease that affects more than 73 million Americans, and increases the risk and severity of adverse cardiovascular events. One of the hallmark features of hypertension is increased calcium-dependent arterial myogen | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF LOUISVILLE | $266,390 | Grant | Trans-NIH Recovery Act Research Support: The study is designed to define mechanisms of fibrinogen (Fg) interaction with vascular endothelial cells (EC) that results in increased permeability of the EC monolayer. Based on our preliminary study, we expect that at a higher dose (4 mg/ml) Fg will ac | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF MEMPHIS | $42,303 | Grant | Trans-NIH Recovery Act Research Support: The parent award, HL 084007 Computational Approach to Ligand Discovery for LPA GPCR and PPAR, includes three specific aims that collectively address a single fundamental question. Namely, what structural characteristics confer selective agonist and/or ant | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| CORNELL UNIVERSITY, INC | $200,001 | Grant | Trans-NIH Recovery Act Research Support: Pharmacological treatment of cardiac arrhythmia is a long sought and as yet elusive goal. Poor efficacy and outcomes in treating arrhythmia with drugs is due, in part, to failure to accurately predict how drugs with implicitly complex pharmacodynamics aff | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $247,460 | Grant | Trans-NIH Recovery Act Research Support: This main goal of this proposal is to investigate whether ERa or ER+? or simultaneous activation of both receptor subtypes are required to rescue heart failure by estrogen treatment. Using estrogen receptor alpha (ERa) and beta (ER+?) knockout and transge | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $53,900 | Grant | Trans-NIH Recovery Act Research Support: Development of brain tumor therapies directed against brain tumor stem cells. Malignant brain tumors, especially glioblastoma multiforme (GBM) contain stem cell-like cells with the capacity to divide and produce new tumors. It is our goal to develop novel | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF MASSACHUSETTS | $263,168 | Grant | Trans-NIH Recovery Act Research Support: ARRA-DNA Mismatch and Double-Strand Break Repair Homologous recombination is a mechanism that is essential to allow cells to tolerate DNA damage produced by various DNA damaging agents. The long term goals of the parent proposal are to define the mechanis | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF ARKANSAS SYSTEM | $24,650 | Grant | Trans-NIH Recovery Act Research Support: Therapeutic Computer Activity Intervention in Alzheimer's Disease--The supplement supports Recovery Act goals and provides summer job opportunity to undergraduate nursing students with intensive research experiences which may encourage them to pursue rese | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $148,469 | Grant | Trans-NIH Recovery Act Research Support: METHYLATION AND RELATED ANOGENITAL HPV CANCERS. This grant funding will allow us to bridge valued colleagues in a way that can significantly accelerate our research activities and promote early dissemination of scientific findings from completed laborator | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| THE CHILDRENS HOSPITAL LOS ANGELES | $113,832 | Grant | Trans-NIH Recovery Act Research Support: More than 50% of all American high school (HS) students will be the children of todayG??s American minorities by 2025G??of those, 75% will be Hispanic. HS and college graduation rates for minority students have failed to improve and only 50% of Hispanic H | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF MASSACHUSETTS | $391,146 | Grant | Trans-NIH Recovery Act Research Support: This program continues to study the tissue specific and developmental regulation of a bone essential transcription factor Runx2 and bone-specific matrix protein, the osteocalcin (OC). In the current program period, we discovered a regulatory network of h | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $216,325 | Grant | Trans-NIH Recovery Act Research Support: The Aims of the supplemental grant were to initiate genome-wide DNA binding studies of nucleoid/chromatin-associated proteins and to determine their global effects on gene expression. Work focused on the yeast S. cerevisiae HMGB protein Nhp6A and the bac | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| UNIVERSITY OF NEBRASKA | $369,275 | Grant | Trans-NIH Recovery Act Research Support: Gene expression signatures that define the common categories of non-Hodgkin's lymphoma (NHL) have been identified, including some unique subtypes not recognized previously. Molecular prognosticators for these NHLs have also been described. We have recentl | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| UNIVERSITY OF TENNESSEE | $137,197 | Grant | Trans-NIH Recovery Act Research Support: The Administrative Supplement to Look AHEAD will increase the scientific impact of Look AHEAD and retain and/or create new staff positions. Look AHEAD is a randomized, controlled, multi-center clinical trial comparing the long-term health effects of an i | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| CHILDREN'S HOSPITAL & RESEARCH CENTER | $5,100,000 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this project is to extend the scientific value of the resources generated by the Knockout Mouse Project (KOMP). The overall aim of KOMP is to dramatically increase the number of unique knockout alleles crucial to many fields of translationa | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $510,059 | Grant | Trans-NIH Recovery Act Research Support: This award was issued as a supplement to the existing NIMH grant 'Epidemiology - National Comorbidity Survey Replication', a nationally representative study of the prevalence and correlates of DSM-IV (Diagnostic and Statistical Manual of Mental Disorders) | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| JAEB CENTER FOR HEALTH RESEARCH FOUNDATION, INC. | $85,070 | Grant | Trans-NIH Recovery Act Research Support: This award provides additional funding for the provision of Electronic Visual Acuity systems for 2 U10 EY011751-13 Pediatric Eye Disease Investigator Group Coordinating Center. | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $299,992 | Grant | Trans-NIH Recovery Act Research Support: Biological Radioprotectors aimed at developing products for national emergencies involving radiation exposure. Using high throughput screening we have identified 2 classes of antibiotics that have protect and mitigate against radiation damage to murine a | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $53,807 | Grant | Trans-NIH Recovery Act Research Support: Osteoporosis and depression are increasingly important health problems in the United States. Reports demonstrating lower bone mineral density and increase fracture risk in patients with depression as compared with those without depression suggest that BMD | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| HEALTH RESEARCH, INC. | $100,000 | Grant | Trans-NIH Recovery Act Research Support: Lung cancer is the most frequent cause of cancer death in both men and women in the United States. Lymph node staging provides the most important prognostic information in patients with loco-regional nonsmall cell lung cancer. The parent grant is involves | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF ILLINOIS | $52,189 | Grant | Trans-NIH Recovery Act Research Support: This award provides funding to support research activities outlined in the K-23 Childhood Cancer Survivors Program to Empower Action in Care. The funds supported work that was completed by contract with the Health Communication Research Lab at Washington | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $54,000 | Grant | Trans-NIH Recovery Act Research Support: In the past decade, as the incidence of end-stage renal disease has grown and the number of cadaveric kidneys has remained stagnant, there has been a dramatic increase in the use of living kidney donors. Several studies and our preliminary data have demon | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $38,907 | Grant | Trans-NIH Recovery Act Research Support: Alexander disease is a rare and typically fatal neurodegenerative disease that results from heterozygous mutations in the gene encoding the type III intermediate filament protein GFAP. The pathological signature of the disorder is the Rosenthal fiber, a c | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $109,212 | Grant | Trans-NIH Recovery Act Research Support: The Rural Health Care Center, funded by the National Institute of Nursing Research, provides an infrastructure necessary to conduct and disseminate research responsive to the health care needs of impoverished individuals, racial and ethnic minorities, and | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| UNIVERSITY OF ARKANSAS SYSTEM | $854,803 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this grant is to support a translational project concerning viral protein interactions under the auspices of COBRE Center for Protein Structure and Function, grant 1 20 RR15569. Genetic diversity of the influenza virus along with its abili | Health and Human Services, Department of / National Institutes of Health | 8/18/2009 |
| UNIVERSITY OF PITTSBURGH THE | $257,357 | Grant | Trans-NIH Recovery Act Research Support: These funds will focus on expanding the Pilot and Feasibility program and purchasing equipment to support ongoing and pending obesity-related research at the University of Pittsburgh. | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| WASHINGTON UNIVERSITY, THE | $52,322 | Grant | Trans-NIH Recovery Act Research Support: Our philosophy is that the most effective way to develop new opportunities in digestive diseases research is to invest in motivated individuals, especially at early stages in their career. This supplement allows us to provide undergraduates with funded r | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| UNIVERSITY OF PITTSBURGH THE | $400,722 | Grant | Trans-NIH Recovery Act Research Support: This project is one of three that compose the University of Pittsburgh Autism Center of Excellence (ACE). The Pittsburgh ACE is learning more about brain differences in autism and how individuals with autism process information. This administrative supp | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| NEW YORK BLOOD CENTER, INC., THE | $99,998 | Grant | Trans-NIH Recovery Act Research Support: The purpose of the grant is to purchase two instruments that will help to pursue the Specific Aims outlined in the original grant (1R01AI081604-01A1). The award is expected to expedite the goal of the original project. | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| NEW YORK MEDICAL COLLEGE | $217,929 | Grant | Trans-NIH Recovery Act Research Support: Lyme disease is the most commonly reported arthropod-borne disease in the United States and the number of reported cases has doubled to over 20,000 per year during the past decade. Lyme disease is caused by the bite of a tick infected with the spirochete, | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF ROCHESTER | $213,616 | Grant | Trans-NIH Recovery Act Research Support: The administrative supplement funding will be used to develop a novel near infrared imaging method to quantify lymphatic draining function in the joint tissues of murine models of arthritis and to examine if improved lymphatic flow could reduce the joint | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| THE VANDERBILT UNIVERSITY | $84,502 | Grant | Trans-NIH Recovery Act Research Support: This supplemental project proposes two new global surveys of genes with metastatic potential in parallel. A meta?analysis strategy will be used to identify candidate genes based on our newly developed human cancer signature database. The whole transcripto | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| THE VANDERBILT UNIVERSITY | $29,155 | Grant | Trans-NIH Recovery Act Research Support: Inflammatory bowel diseases are associated with increased risk of early-onset colorectal cancer, incurring great cost both economically and in patient morbidity and mortality. Intensive research has been focused on identifying signaling pathways which may | Health and Human Services, Department of / National Institutes of Health | 7/28/2009 |
| UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE | $40,324 | Grant | Trans-NIH Recovery Act Research Support: Supplement 3K01DK081444-02S1 for the purchase of an Olympus BX51 microscope and a Grass S88X nerve stimulator will enhance productivity on the parent award by: 1. Increasing the pace of experiments designed to investigate pelvic neuron function in diabe | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| BOSTON MEDICAL CENTER CORPORATION | $91,736 | Grant | Trans-NIH Recovery Act Research Support: This project aims to: (1) examine time trends in time to MPM, all cause mortality, and cancer specifict mortality in relation to sociodemographic factors; (2) identify sociodemographic, first primary breast cancer and treatment characteristics associated | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| THE MEMORIAL HOSPITAL | $106,947 | Grant | Trans-NIH Recovery Act Research Support: Rates of colorectal cancer screening are low despite evidence that screening methods are effective in reducing colorectal cancer-related mortality. Although several effective screening methods are available, only half of eligible Americans have been scre | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $53,425 | Grant | Trans-NIH Recovery Act Research Support: The present proposal will enhance the activities of a K07-funded clinical trial and accelerate the pace of the science by increasing the study sample size, increasing the rate at which we can complete recruitment, randomization, intervention activities, d | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $107,249 | Grant | Trans-NIH Recovery Act Research Support: This application is for a career development award. The overall goal of this award is to provide training and skills needed to conduct large-scale mass communication studies examining the impact of visual media on adolescent dietary behavior. A multidisci | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF ROCHESTER | $100,064 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this administrative supplement is to fund two enhancements to a current K07-funded intervention to promote physical activity in underserved patients. First, we propose a more comprehensive and coordinated physical activity program. Second, | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $48,523 | Grant | Trans-NIH Recovery Act Research Support: Haemophilus ducreyi causes the genital ulcer disease, chancroid. Like other GUDs, chancroid facilitates the acquisition and transmission of HIV. Understanding bacterial factors that contribute to H. ducreyi pathogenesis is a prerequisite for the developme | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $50,000 | Grant | Trans-NIH Recovery Act Research Support: This proposal describes a 5-year training program for the development of an academic career in Clinical Pathology. The candidate is completing residency training in clinical laboratory medicine at Harvard Medical School, Boston, and now proposes to expand | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $33,924 | Grant | Trans-NIH Recovery Act Research Support: The Disease Initiation and the role of DCs in the TRUC Model of ulcerative colitis | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $88,366 | Grant | Trans-NIH Recovery Act Research Support: This K08 Award focuses on the role of Extracellular matrix metalloprotease inducer (EMMPRIN or CD147) as a tumor cell surface molecule that promotes tumor-stromal interactions in head and neck squamous cell carcinoma (HNSCC). As outlined in the first two | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $69,619 | Grant | Trans-NIH Recovery Act Research Support: As a physician trained in medical oncology, I aim to develop the skills necessary to allow me to become an independent translational physician-scientist. The goal of this proposal is to identity the genetic basis for carcinomas of the stomach and esophagu | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF MIAMI | $108,009 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement supported the hiring of a new research technician who assists with the scientific tasks of this grant. This grant is accelerating the rate of research discovery which is aimed at understanding the cellular and molecular mech | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UMDNJ-ROBERT WOOD JOHNSON MEDICAL SCHOOL | $42,000 | Grant | Trans-NIH Recovery Act Research Support: Purpose of this award is to provide funding for the salary and fringe benefits of a laboratory technical personnel who will provide support and assistance in the exection of project-related experiments. By maximizing the hours worked, it is expected that | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $85,500 | Grant | Trans-NIH Recovery Act Research Support: This supplement prevented job loss, thereby stimulated the American economy, and accelerated our anesthetic mechanisms research, a fundamental biological problem for 25,000,000 Americans undergoing anesthesia annually | Health and Human Services, Department of / National Institutes of Health | 9/08/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $108,000 | Grant | Trans-NIH Recovery Act Research Support: This proposal describes a 5-year training program for the development of an independent investigator in volatile anesthetic mechanisms. The principal investigator is a faculty member in the Department of Anesthesia, Harvard Medical School, with a backgrou | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $67,849 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this supplement is to accelerate the pace of the parent grant entitled Hippocampal Neurogenesis: Mechanisms of antidepressant action. This will be accomplished through the creation of an additional 50% time technician position who was hired | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| WAYNE STATE UNIVERSITY (INC) | $40,000 | Grant | Trans-NIH Recovery Act Research Support: Specific aim one is to chategorize dopamine in BDNF mice using microdialysis and voltammetry. The second specific aim foscused on characterizing BDNF levels using an ELISA assay. The first goal is to use standard tissue and imaging techniques to view th | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF PUERTO RICO-MEDICAL SCIENCES CAMPUS | $145,650 | Grant | Trans-NIH Recovery Act Research Support: During the next two years this project will test the hypothesis that abnormal imprinting of the IGF2 gene is a biomarker for colorectal cancer (CRC) predisposition, which exerts its increase risk via the IGF axis, resulting in specific pathological and mo | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF WASHINGTON | $73,152 | Grant | Trans-NIH Recovery Act Research Support: The general objectives of my proposed research plan are to elucidate the mechanism of genomic instability induced by replication fork instability and to use a single-stranded DNA (ssDNA) mapping technique to identify origins of replication and chromosome | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $32,862 | Grant | Trans-NIH Recovery Act Research Support: Na dependent neurotransmitter transporters or neurotransmitter sodium symporters (NSS) are integral membrane proteins that play a critical role in terminating synaptic transmission and, thus, in shaping the duration and magnitude of synaptic signaling. Th | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| WASHINGTON UNIVERSITY, THE | $143,620 | Grant | Trans-NIH Recovery Act Research Support: This is a request for an administrative supplement to enable the successful conduct of Project 1, 'Preclinical Alzheimer's disease predicts poststroke dementia' (JC Morris, Project Leader), of the program project grant, 'Healthy Aging and Senile Dementia' | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $99,949 | Grant | Trans-NIH Recovery Act Research Support: The aging of the brain is a cause of cognitive decline in the elderly and the major risk factor for neurodegenerative diseases. An exciting recent development is the elucidation of a pattern of DNA damage in the aging human brain that is associated with r | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $165,779 | Grant | Trans-NIH Recovery Act Research Support: Effective prevention strategies for HIV are critically needed, and an effective HIV vaccine is the best long-range hope to dramatically reduce the rate of new HIV infections. To this goal, our current understanding of the biology and epidemiology of HIV t | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $64,414 | Grant | Trans-NIH Recovery Act Research Support: This PPG was initiated in 1998 in response to a RFA for Human Immunology Centers of Excellence and has a well-defined, central focus on the mechanisms of antigen presentation and T cell recognition in human autoimmune diseases, in particular multiple scle | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $716,480 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of the program is to identify genes that predispose to childhood cancer, the molecular pathways to tumor development, and the clinical implications. We have focused on two model familial syndromes of childhood and adolescent cancers, sarc | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| PURDUE UNIVERSITY | $477,847 | Grant | Trans-NIH Recovery Act Research Support: SUMMARY: Natural Inhibitors of Carcinogenesis (P01 CA48122) is uniquely designed discovery new cancer chemopreventive agents from deep ocean sediment-derived microorganisms, and promote these discoveries to the level of structurally- and mechanistically- | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| UNIVERSITY OF TEXAS M.D. ANDERSON CANCER CENTER, THE | $151,419 | Grant | Trans-NIH Recovery Act Research Support: Signaling transduction pathways and networks have recently proven to be attractive targets for cancer therapy. Gleevac, herceptin (TM), C225, Irressa, and CCI779 have all induced remarkable, non-toxic responses in a subset of patients where abnormalities | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $104,906 | Grant | Trans-NIH Recovery Act Research Support: Funds are requested for the purchase of three pieces of equipment: a Quantitative Real-time Polymerase Chain Reaction (QPCR) instrument from Agilent Technologies, a Fluorescent Microscope from Carl Zeiss Microimaging, Inc., and a Victor 3V Fluorescence, | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF CHICAGO, THE | $42,744 | Grant | Trans-NIH Recovery Act Research Support: Two undergraduate students will receive broad research training, including research design and methods focused on determining the molecular, cellular, biochemical and behavioral consequences of exposure to nicotine. This training will span the theoretica | Health and Human Services, Department of / National Institutes of Health | 6/19/2009 |
| UNIVERSITY OF UTAH, THE | $687,001 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): There are >10,000 species of venomous marine snails belonging to the superfamily Conoidea; one group in the superfamily are the cone snails (Conus). The general goal of this program is to develop highly selective pepti | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $435,487 | Grant | Trans-NIH Recovery Act Research Support: One aim of our P01 grant was to define and test genes capable of reprogramming human somatic cells to a pluripotent state. From this project we have recently described a method to reprogram somatic cells to the pluripotent state. Following the success of | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $596,777 | Grant | Trans-NIH Recovery Act Research Support: ARRA supplement for 5 PO1 GM085354-0 Pluripotent cells have a characteristic cell cycle structure comprising of a relatively short G1 phase (White and Dalton 2005. Stem Cell Reviews 1,131-138). This is underpinned by an unusual mode of molecular regulatio | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| CEDARS-SINAI MEDICAL CENTER | $50,551 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The purpose of this revised application is to improve the International Skeletal Dysplasia Registry Database. The enhanced capabilities of the database will significantly accelerate the research facilitated by the Inte | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| PURDUE UNIVERSITY | $95,500 | Grant | Trans-NIH Recovery Act Research Support: The Surgeon General has stated that environmental and lifestyle changes may hold the most promise for the treatment of obesity. Gaps in knowledge about the physiological and behavioral control mechanisms on which dietary and environmental factors operate | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $169,500 | Grant | Trans-NIH Recovery Act Research Support: The long-term objective of this application for an administrative supplement is investigate the roles of viral and host gene expression in the interaction of herpes simplex virus with the mammalian nervous system, in particular, latent herpes simplex viru | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| UNIVERSITY OF NEW MEXICO | $916,671 | Grant | Trans-NIH Recovery Act Research Support: This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in oth | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement to our CoBRE entitled ?Signal Transduction in Cancer? is focused on tumor recurrence (relapse and metastasis) as the major cause of lung cancer treatment failures and deaths. To date, there is no clinically applied prognost | Health and Human Services, Department of / National Institutes of Health | 8/25/2009 |
| UNIVERSITY OF IDAHO | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: This project will enhance current NCRR-supported research, student training, and research core facilities that have been scientifically reviewed as part of the IDeA Idaho INBRE Program parent award. The goal is to accelerate the tempo of scientific disco | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF NEBRASKA | $413,452 | Grant | Trans-NIH Recovery Act Research Support: The Nebraska Research Network in Functional Genomics has two major components, the undergraduate campuses located throughout the State and the research campuses located in Omaha and Lincoln. On the undergraduate campuses, INBRE will support 24 faculty dir | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC. | $255,000 | Grant | Trans-NIH Recovery Act Research Support: The Kansas IDeA Network of Biomedical Research Excellence (K-INBRE, first known as the K-BRIN) was established in 2001 as a network of 9 Kansas institutions of higher learning. Kansas falls into the bottom half of states receiving research funding from th | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| MARSHALL UNIVERSITY RESEARCH CORPORATION | $751,506 | Grant | Trans-NIH Recovery Act Research Support: The West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE) has successfully established a summer research program for undergraduate students (interns) and faculty members (fellows) from primarily undergraduate institutions (PUIs) to have | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| MARSHALL UNIVERSITY RESEARCH CORPORATION | $651,385 | Grant | Trans-NIH Recovery Act Research Support: West Virginia is a State that has had a historically low success rate in obtaining grant awards from the National Institutes of Health and has been designated as an IDeA State. Marshall University (MU), in partnership with West Virginia University (WVU), | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF OKLAHOMA | $512,824 | Grant | Trans-NIH Recovery Act Research Support: Medicines, Explorations, and Discoveries in Biotechnology Education (MEDBEd) is the program we will initiate with this workforce development administrative supplemental award. MEDBEd will use lessons we have learned as we implemented our successful SEED | Health and Human Services, Department of / National Institutes of Health | 9/05/2009 |
| NORTH DAKOTA STATE UNIVERSITY | $238,559 | Grant | Trans-NIH Recovery Act Research Support: The goal of the parent grant is to establish a Center for Visual and Cognitive Neuroscience at North Dakota State University. One Center initiative consists in a translational and collaborative project lead by Dr. St+?phane Rainville that aims to accelera | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF OKLAHOMA | $997,203 | Grant | Trans-NIH Recovery Act Research Support: The detailed molecular events underpinning retinal injury in diabetic retinopathy (DR) are not fully understood and convenient biomarkers to predict disease progression are entirely lacking. We now introduce a new concept: that plasma lipoproteins mediat | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| WAKE FOREST UNIVERSITY | $1,434,256 | Grant | Trans-NIH Recovery Act Research Support: This supplemental award provides funding to support the hiring of a hematologist/oncologist with an acute myelogenous leukemia (AML) focus. This award will support the recruitment of a physician-scientist with outstanding laboratory and clinical skills. | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $1,368,146 | Grant | Trans-NIH Recovery Act Research Support: The goal of this Administrative Supplement to the UAB Comprehensive Cancer Center Core Support Grant (2P30 CA 13148-38) is to provide funding for the recruitment of a clinical investigator who is early in his/her career and evinces a strong commitment to | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| DUKE UNIVERSITY | $49,851 | Grant | Trans-NIH Recovery Act Research Support: The Cancer Center will provide two staff persons one experienced with the Cancer Centers IT infrastructure (emphasis in data management) and one experienced with Cancer Center's clinical trial operations. These staff will perform a consultative role for t | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $1,577,730 | Grant | Trans-NIH Recovery Act Research Support: Full-time (12-month) support is requested for two years for a newly appointed tenure-track-equivalent Assistant Professor of Medicine in the Department of Medicine (Hematology & Oncology) at Dartmouth Medical School, Norris Cotton Cancer Center (NCCC), an | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE | $49,994 | Grant | Trans-NIH Recovery Act Research Support: The purpose of the City of Hope Comprehensive Cancer Center is to reduce cancer incidence, morbidity and mortality by providing and organizational structure and administration that enhances the quality and interdisciplinary nature of competitively funded | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $1,461,788 | Grant | Trans-NIH Recovery Act Research Support: The University of Colorado Cancer Center (UCCC) is the only NCI-designated comprehensive Cancer Center in the Rocky Mountain region - an area with a population of approximately eight million people. The goals are to reduce the cancer burden by: 1) conduct | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF PITTSBURGH THE | $49,992 | Grant | Trans-NIH Recovery Act Research Support: As a part of the NCI-designated Cancer Center Supplement of the parent grant P30CA047904, UPCI agrees to participate in the planning activities associated with the project entitled ADOPTion of New Technologies for Remote Data Capture and Protocol Authorin | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $49,537 | Grant | Trans-NIH Recovery Act Research Support: This project is to allow NCI-Designated Comprehensive and Clinical Cancer Centers to participate in the new initiative entitled ADOPTion of New Technologies for Remote Data Capture and Protocol Authoring (ADOPT), which is intended to improve the efficienc | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF IOWA, THE | $49,272 | Grant | Trans-NIH Recovery Act Research Support: The University of Iowa Holden Comprehensive Cancer Center (HCCC), a matrix cancer center at the University of Iowa, is applying for renewal of its Cancer Center Support grant. This is the first competitive renewal application for the HCCC. The Cancer Cent | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $1,450,579 | Grant | Trans-NIH Recovery Act Research Support: This supplement will focus on laboratory based research in nanotherapeutics and nanoimmunotherapeutics in combination with radiation therapy for recurrent glioblastoma patients; and focus on the progression of basic findings to the applied and clinical tr | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| BAYLOR COLLEGE OF MEDICINE | $1,454,750 | Grant | Trans-NIH Recovery Act Research Support: Newly Independent Faculty Physician Recruit Supplement to study the Epigenetic Changes in Malignancy: Therapeutic Targeting of Aberrant DNA Methylation. The proposed newly independent faculty recruit will perform laboratory research to more fully chara | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC. | $49,960 | Grant | Trans-NIH Recovery Act Research Support: To support the ADOPTion of New Technologies for Remote Data and Capture and Protocol Authoring, by providing appropriate clinical and informatics expertise in scheduled meetings and conference calls. | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| ST LUKE'S-ROOSEVELT HOSPITAL CENTER | $27,114 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this supplement is to give extra research experience to Master?s students at Columbia University in an effort to interest them in a research/academic career. Three students were chosen for 2009 (Jennifer Ahn, Carl Dambkowski, and David Gol | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $299,008 | Grant | Trans-NIH Recovery Act Research Support: UAB's Clinical Nutrition Research Unit (CNRU) was inaugurated through NIH funding in 2000 and is also supported by UAB's formal system of University-wide Interdisciplinary Research Centers. Our CNRU fosters multidisciplinary, collaborative approaches to b | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $270,500 | Grant | Trans-NIH Recovery Act Research Support: The Digestive Disease Center (DDC) at Stanford University comprises a powerful blend of several clinical and basic science departments, bringing together 34 Research Base Investigators (RBIs) and 13 Associate Members from various disciplines. The DDC tar | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $300,000 | Grant | Trans-NIH Recovery Act Research Support: AWARD TITLE: The UNC Nutrition Obesity Research Center ARRA Administrative Supplement DESCRIPTION OF ARRA-FUNDED PROJECT: The UNC Nutrition Obesity Research Center (NORC) requested funding from the ARRA supplement program (1) to purchase new equipment t | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $302,473 | Grant | Trans-NIH Recovery Act Research Support: We are requesting additional, recently available equipment that will allow for new microscopic studies of great importance to the Nephrology community. In particular the recently available Spectraphysics iris HF 50 Optical Parametric Oscillator laser wil | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $276,813 | Grant | Trans-NIH Recovery Act Research Support: The proposed work represents an entirely unique area of kidney research that has not been previously interrogated in either the laboratory or the clinic. By investigating a novel SERM of which level rise progressively with age, this proposed project has | Health and Human Services, Department of / National Institutes of Health | 8/12/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $363,337 | Grant | Trans-NIH Recovery Act Research Support: This supplemental application for the UAB-UCSD O'Brien Core Center for Acute Kidney Injury (AKI)(1P30 DK079337) in response to NIDDK FY2009 Program for Administrative Supplements Utilizing Recovery Act Fund (NOT-OD-09-056) is designed to facilitate new an | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $309,000 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION, OVERALL (provided by applicant): The focus for the George M. O'Brien Kidney Centers has been basic science investigation that has very successfully defined kidney structure, function and disease mechanisms. New technologies now provide opport | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $373,974 | Grant | Trans-NIH Recovery Act Research Support: ARRA - UNC-CH Center for Environmental Health and Susceptibility Recovery Act Administrative Supplement This supplement was requested by our Center to accelerate the pace of CEHS research and allow job creation as follows: (1) creating two Graduate Resear | Health and Human Services, Department of / National Institutes of Health | 9/06/2009 |
| THE VANDERBILT UNIVERSITY | $118,458 | Grant | Trans-NIH Recovery Act Research Support: This project extends the work of our P30 GrantG??s Clinical Recruitment Core (Core E) by linking to our existing (linked) databases TennesseeG??s Newborn Hearing Screening and Cancer Registry databases. Over the past few years, Core E methodologists have | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $399,761 | Grant | Trans-NIH Recovery Act Research Support: This Competitive Revision Application is in response to Notice Number (NOT-OD-09-058) - Recovery Act Funds for Competitive Revision Applications. In this competitive revision application, we are adding a new set of resources to an existing P30 grant, Cent | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $1,456,998 | Grant | Trans-NIH Recovery Act Research Support: SPORE in Breast Cancer - ARRA The Carolina Breast Cancer Study (CBCS) was originally funded by the UNC SPORE in Breast Cancer. This landmark population-based study of breast cancer enrolled 2311 women, nearly 50% of whom were African American. CBCS has | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $120,294 | Grant | Trans-NIH Recovery Act Research Support: While the African-American population has large differences in various neoplastic disease processes especially in neoplastic disease of the breast and prostate, very few African-Americans have been recruited into graduate programs for the Doctor of Philos | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $348,432 | Grant | Trans-NIH Recovery Act Research Support: The focus of this research program is age-related hearing loss (presbyacusis), a disorder that contributes to poor communication abilities and reduced quality of life for millions of Americans. Scientific projects examine age-related changes in speech un | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $212,191 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement supports the aims of one of the four interrelated projects of the parent grant, ?The Role of Airborne PAHs and DEP in the Pathogenesis of Childhood Asthma.? Project 3, ?Prenatal PAH Exposure, Epigenetic Changes, and Asthma, | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF HOUSTON SYSTEM | $363,777 | Grant | Trans-NIH Recovery Act Research Support: The objective of this request for an administrative supplement to 2 P50 HD052117-03, Texas Center for Learning Disabilities, to take advantages of unique opportunities to accelerate the tempo of the science of this synergistic, multi-disciplinary research | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $305,041 | Grant | Trans-NIH Recovery Act Research Support: The central theme of the application for a Boston Center for Intervention Development and Applied Research (CIDAR) is Vulnerability to Progression in Schizophrenia. We see two major strengths of the proposal. First we study subjects who are at various sta | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF MARYLAND | $91,709 | Grant | Trans-NIH Recovery Act Research Support: This request for supplemental funding under the Recovery Act Limited Competition for Revision Applications (NOT-OD-09-058) for grant PSO MH082999-01 addresses the topic of Translational Science: Innovative Targets and Models for Developing Treatments for | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF CINCINNATI | $111,195 | Grant | Trans-NIH Recovery Act Research Support: The long-term overall goal of this Specialized Program of Translational Research in Acute Stroke SPOTRIAS) is to enhance and accelerate recovery of acute stroke patients by focused and innovative rapid nterventions for ischemic and hemorrhagic stroke. Thi | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| DUKE UNIVERSITY | $266,476 | Grant | Trans-NIH Recovery Act Research Support: High-resolution and high-speed diffusion-weighted magnetic resonance imaging (MRI) techniques are highly desireable for clinical imaging. The rapidly growing availability of high-field MRI scanners and the increasing number of receiving coils have created | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $42,707 | Grant | Trans-NIH Recovery Act Research Support: The funds from this supplement will be used to hire an additional technician. The tech will assist with maternal behavior and feeding behavior experiments to increase the tempo of our research within the scope of the parent grant and shorten the time requ | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $58,869 | Grant | Trans-NIH Recovery Act Research Support: The primary goal is to increase understanding of the initial molecular targets for ethanol ligand-gated ion channels (LGICs). The proposal builds on our previous work which found that increased atmospheric pressure (pressure) antagonizes ethanol at the be | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| BROWN UNIVERSITY IN PROVIDENCE IN STATE OF RI AND PROVIDENCE PLANTATIONS | $154,741 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Alcohol-positive trauma patients are more likely to be readmitted to a trauma center or die from a subsequent injury than are alcohol-negative trauma patients. Despite their increased risk, there are few empirically-su | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $331,832 | Grant | Trans-NIH Recovery Act Research Support: The central question addressed by this Competitive Revision Application is whether prenatal exposure to moderate level alcohol alters the levels of biogenic amines in brain regions and consequently alters the predisposition to consume alcohol during adult | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $133,366 | Grant | Trans-NIH Recovery Act Research Support: Herein we submit a revision of a model of biobehavioral development that focuses on the origins of individual differences in voluntary alcohol consumption in young socially housed bonnet macaque monkeys. Differences in early maternal care are suggested as | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $232,165 | Grant | Trans-NIH Recovery Act Research Support: Environmental Strategies for Violence and AOD Prevention: Administrative Supplement to Provide Summer Research Experiences for Educators, College Students & High School Students. The purpose of the supplement is to conduct an expanded environmental survey | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $115,398 | Grant | Trans-NIH Recovery Act Research Support: The proposed supplement extends current research efforts of the parent grant to address a current policy issue of critical importance. The goal of the parent grant was to develop a systems model of college drinking (i.e., SimHED) that could be used to sim | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| MAYO CLINIC | $237,227 | Grant | Trans-NIH Recovery Act Research Support: This is an administrative supplement request for parent grant Identifying Mechanisms of Dementia: Role for MRI in the Era of Molecular Imaging, R01 AG11378. The performance dates of the parent grant are 9/1/2008-7/31/2013. The overall goal of this parent | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | $31,141 | Grant | Trans-NIH Recovery Act Research Support: Osteoporosis and obesity are both important public health problems. Weight (wt) reduction is recommended to reduce obesity-related complications, but induces bone loss (even with adequate Ca intake) in post- menopausal women. Although several studies have | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| WAYNE STATE UNIVERSITY (INC) | $138,482 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of the current proposal is to examine the underlying mechanisms for the age-related rise in colorectal cancer, with particular reference to assessing the involvement of cancer stems (CSC) in carcinogenesis. | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| RAND CORPORATION. THE | $175,000 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This application is for a competing continuation of the currently funded project Internet Interviewing and the HRS. The current project is a joint collaboration between RAND and the University of Michigan. Its broad ob | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| MAYO CLINIC | $538,033 | Grant | Trans-NIH Recovery Act Research Support: This application is being submitted in response to Notice Number NOT-OD-09-058, NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications. This competitive revision application pertains to parent grant 1RO1 AG026094, The S | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $185,353 | Grant | Trans-NIH Recovery Act Research Support: Tissue regenerative capacity deteriorates with age in many degenerative disorders, leading to the loss of organ function. Our previous work demonstrated that in aged skeletal muscle, the regenerative ability of muscle stem cells, termed satellite cells, w | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO | $249,036 | Grant | Trans-NIH Recovery Act Research Support: These supplemental funds will continue work on the development of new treatments for brain injury and will providing funding for to create a new scientist position. | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO | $270,579 | Grant | Trans-NIH Recovery Act Research Support: The ability of humans to mount an effective immune response declines with age, leaving the elderly susceptible to infectious diseases and cancer. Moreover, vaccines tested in younger individuals are often ineffective in older people. Thus, as new vaccines | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) | $30,076 | Grant | Trans-NIH Recovery Act Research Support: This grant provided a summer research experience for one science educator in health-related scientific research. | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $66,435 | Grant | Trans-NIH Recovery Act Research Support: This competitive renewal will build upon our previous work on the role of chemokines and their receptors in airway inflammation. Children that had experienced severe responses to RSV infections often progress into developing long-term pulmonary problems. | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $316,385 | Grant | Trans-NIH Recovery Act Research Support: Great progress has been made over the past decade in elucidating pathophysiologic mechanisms in airways inflammatory diseases. Considerable controversy remains however, relating to the specific role of chemokines and their receptors in orchestrating the p | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $39,950 | Grant | Trans-NIH Recovery Act Research Support: The latent reservoir for HIV-1 in resting CD4+ T cells is a major barrier to virus eradication. There is great current interest in developing strategies for eliminating this reservoir. This will require a more complete understanding of the molecular mecha | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| THE GEORGE WASHINGTON UNIVERSITY | $134,687 | Grant | Trans-NIH Recovery Act Research Support: The current proposal aims to extend our previous results, which were obtained during the past four years on the effect of Tat peptide derivatives in inhibition of HIV-1. Previous specific aims were successfully met in a timely manner, and they included de | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $141,850 | Grant | Trans-NIH Recovery Act Research Support: In our grant application, as part of Aim 2, we had proposed to study the role of SHP-1 in CD4+CD25+Foxp3+regulatory T cells. These studies have resulted in some very interesting findings not only defining a role for SHP-1 in Treg cells, but also addressi | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $25,839 | Grant | Trans-NIH Recovery Act Research Support: The long term objective of this application is to understand how HIV evades the immune response and establishes a chronic infection. Insights into how this occurs may lead to new strategies to augment the ability of the immune response to eradicate the vi | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $107,122 | Grant | Trans-NIH Recovery Act Research Support: Asthma affects millions of people worldwide and is gaining prevalence in the U.S. with the greatest increase seen among inner city African Americans and Hispanics. The reasons for this increase are not well understood, but may be the result of a complex i | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $320,957 | Grant | Trans-NIH Recovery Act Research Support: TNF binding to its receptor TNFR1 triggers cell survival or cell death but the mechanisms that determine which of these two divergent responses is triggered remain to be fully elucidated. One cell death checkpoint is the activation of NF-kappaB transcript | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| GEORGETOWN UNIVERSITY (THE) | $145,825 | Grant | Trans-NIH Recovery Act Research Support: In this competive renewal period we will: 1) Continue to define function of PfCRT isoforms via heterologous expression in yeast and analysis of purified membrane, ISOV, and PL preparations. We will use recently invented techniques and chemical probes for | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| SEATTLE CHILDREN'S HOSPITAL | $278,321 | Grant | Trans-NIH Recovery Act Research Support: HHV-6 and CNS disease following stem cell transplant -- Human herpesvirus 6 (HHV-6) has been implicated as an important cause of morbidity and mortality following hematopoietic cell transplantation (HCT). There are compelling data linking human herpesv | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| CEDARS-SINAI MEDICAL CENTER | $369,445 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The overall goal of the proposed studies is to define the mechanisms by which MD-2, a co-receptor to TLR4 participates in LPS-induced signaling, to investigate the regulation of MD2 promoter and to characterize the exp | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $20,186 | Grant | Trans-NIH Recovery Act Research Support: Herpes viruses comprise a large family of complex, double-stranded DNA viruses, a number of which are serious human pathogens. Herpes DNA replication requires a group of virally encoded proteins, and is the target of several antiviral drugs. However, the | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| BOSTON MEDICAL CENTER CORPORATION | $58,178 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this proposal is to characterize how T cell receptor and costimulatory signals influence HIV-1 transcription. As part of the parent grant, we have generated a number of cell lines expressing CD8/CD28 chimeric receptors that will allow | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| MICHIGAN STATE UNIVERSITY | $146,087 | Grant | Trans-NIH Recovery Act Research Support: Human Immunodeficiency Virus Type 1 (HIV-1) infects CD4-positive T cells and monocytes/macrophages and cause Acquired Immune Deficiency Syndrome (AIDS) in humans. Research proposed in this application is focusing on the cellular factors that resist HIV-1 | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $136,719 | Grant | Trans-NIH Recovery Act Research Support: Treg Migration in GVHD (ARRA) This project involves the evaluation of regulatory T cell migration during graft-versus-host disease. The purpose of the award was to provide us with support to use intravital microscopes that were recently purchased by UNC t | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $125,159 | Grant | Trans-NIH Recovery Act Research Support: The Role of MerTK in Autoimmune Diabetes 5 R01 AI066075-04 ARRA MerTK belongs to a small family of receptor tyrosine kinases (RTK), which includes Axl and Tyro3. These 3 RTK are expressed by dendritic cells (DC), and each may have distinct functions des | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $99,994 | Grant | Trans-NIH Recovery Act Research Support: funds were awarded for purchase of a high thoughput microscope to screen a random GFP library in the protozoan pathogen Giardia. the salary for one technician was *not* awarded. | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $267,071 | Grant | Trans-NIH Recovery Act Research Support: Autoimmune liver disease involves the combined activity of multiple immune cell types in the liver, involving cells of the adaptive immune system, particularly antigen-specific Th1 cells, and cells of the innate immune system. We hypothesize that specific | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF ROCHESTER | $68,890 | Grant | Trans-NIH Recovery Act Research Support: The supplement will allow us to purchase equipment that will allow much more efficient microbiologic evaluation of respiratory and serum specimens collected from volunteers. Two freezers will be purchased to allow storage of patient samples. The equipmen | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $6,071 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this award is to provide a short-term summer employment and a unique biomedical research opportunity for college students in 2009 and 2010 who are interested in pursuing a career in science and intend to go to a graduate or medical school. | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| COLORADO STATE UNIVERSITY | $99,900 | Grant | Trans-NIH Recovery Act Research Support: Chromosomal aberrations figure prominently as the underlying cause of many untoward biological effects caused by exposure to ionizing radiation (IR). These include acute effects responsible for cell and organism death, as well as delayed effects, principa | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| SOUTHERN ILLINOIS UNIVERSITY | $19,788 | Grant | Trans-NIH Recovery Act Research Support: This award was intended to provide a summer research experience for an undergraduate student in the context of the parent grant. A student was hired from Illinois College into the lab for the summers of 2009 and 2010. | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| CORNELL UNIVERSITY, INC | $95,900 | Grant | Trans-NIH Recovery Act Research Support: Tuberculosis is an extremely successful pathogen with a penetrance of its host population, mankind, that is estimated by WHO to be close to 1/3 of the population of the planet. In areas of high endemnicity for HIV infection, such as Sub-Saharan Africa, tu | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $157,297 | Grant | Trans-NIH Recovery Act Research Support: Skeletal muscle is terminally differentiated and as such, cannot regenerate. The cells responsible for muscle regeneration are known as satellite cells, which are normally quiescent and reside between the basement membrane and the sarcolemma of the muscle | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| RENSSELAER POLYTECHNIC INSTITUTE | $85,219 | Grant | Trans-NIH Recovery Act Research Support: The kinetic and structural mechanisms by which myosin and other motor proteins convert the chemical energy of ATP hydrolysis into force and motion are far from being understood. This project will test our kinetic hypothesis that unloaded velocity and osci | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| RHODE ISLAND HOSPITAL | $1,491,790 | Grant | Trans-NIH Recovery Act Research Support: The objective of this study is to improve the functional healing of an anterior cruciate ligament reconstruction (ACLR) by using a collagen-platelet composite to enhance the biologic incorporation of the graft. The current ?standard of care? for an anteri | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF WASHINGTON | $664,000 | Grant | Trans-NIH Recovery Act Research Support: In contrast to Ag-specific alphabeta T cells, gammadelta T cells can kill malignantly transformed cells in a manner that does not require the recognition of tumor-specific antigens. Cancerous cells are now known to display a number of stress-induced Ags | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $605,699 | Grant | Trans-NIH Recovery Act Research Support: Carpal tunnel syndrome (CTS), the most common entrapment neuropathy, is exceeded only by low back pain as a cause of employee absenteeism. Maladaptive neuroplasticity in the brain of CTS patients has been noted by several neuroimaging studies, and include | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $194,985 | Grant | Trans-NIH Recovery Act Research Support: The parent project is designed to evaluate local and systemic inflammation as biomarkers of adenoma risk. We have made progress in the original aims proposed in the parent grant. During the last 3 years, we have recruited xx number of patients, however, a | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF MARYLAND BALTIMORE COUNTY | $662,733 | Grant | Trans-NIH Recovery Act Research Support: This supplement proposes to begin to place the chemical damage wrought by the major metabolite of the carcinogen NMOR in the context of biological processes that bear on the consequences of the damage. | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $340,394 | Grant | Trans-NIH Recovery Act Research Support: The goals of this project are to return to active follow-up former participants in the National Wilms Tumor Study (NWTS) Late Effects Study and to accelerate the analysis and publication of study data. The study facilitates the comparative evaluation o | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC. | $840,347 | Grant | Trans-NIH Recovery Act Research Support: Hepatitis B virus (HBV) is a major cause of serious liver diseases, including chronic hepatitis, cirrhosis and hepatocellular carcinoma (HCC) throughout the world and the US, especially among minorities including African Americans, Native Americans, and A | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $311,586 | Grant | Trans-NIH Recovery Act Research Support: Selenium is an essential trace element in the diets of mammals because of its presence in selenocysteine- containing proteins. Clinical trials and animal studies have demonstrated the potent cancer prevention activity of selenium; however, mechanisms by w | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE | $254,201 | Grant | Trans-NIH Recovery Act Research Support: The gammaretroviruses represent a group of mammalian oncogenic retroviruses typically associated with the long-latency induction of leukemia and lymphoma in the natural host. Feline leukemia virus (FeLV), a naturally occurring gammaretrovirus, is found in | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC. | $508,515 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Despite high promise the immunotherapeutic strategies that have been tested in clinical trials have not yet delivered tangible benefits to most patients. Numerous clinical trials have demonstrated successful generation | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $349,254 | Grant | Trans-NIH Recovery Act Research Support: A higher order of regulation can be achieved by compartmentalization and functional specialization of the endocytic pathway during signal transduction in response to growth factors (GFs). In contrast, impairment of intracellular (IC) trafficking of GF sig | Health and Human Services, Department of / National Institutes of Health | 9/02/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $294,823 | Grant | Trans-NIH Recovery Act Research Support: DNA damage and repair are fundamental to human health and disease. The long-term objectives of this application are to: expand our understanding of the role of DNA helical distortions in DNA damage recognition and processing; determine the factors influen | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $273,541 | Grant | Trans-NIH Recovery Act Research Support: The major goal of this Administrative Supplement to parent grant R01 CA94900 is to accelerate the tempo of scientific research by allowing us to appoint additional personnel to the project. The parent grant, which will remain active throughout the propose | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| LOVELACE BIOMEDICAL & ENVIRONMENTAL RESEARCH INSTITUTE INC | $1,212,592 | Grant | Trans-NIH Recovery Act Research Support: Lung cancer is the leading cause of cancer-related death in the U.S. and will soon reach epidemic levels worldwide. Mortality from this disease could be reduced through the identification of high-risk individuals and the implementation of effective thera | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE | $304,444 | Grant | Trans-NIH Recovery Act Research Support: Chronic myeloid leukemia (CML) results from transformation of a primitive hematopoietic cell by the BCR-ABL gene. The BCR-ABL tyrosine kinase (TK) inhibitor imatinib is highly effective in inducing remissions and improving survival in CML patients but doe | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| WASHINGTON STATE UNIVERSITY | $130,768 | Grant | Trans-NIH Recovery Act Research Support: Prostate cancer is the major cancer of men, and androgen-independent prostate cancer tends to be highly aggressive and resistant to therapy. Previous research in our laboratory indicates that the androgen-independent prostate cancer cells, DU145 and PC3, | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $162,804 | Grant | Trans-NIH Recovery Act Research Support: Testicular cancer is a disease of very young men. Until recently, it was the leading cancer among men aged 15-29, and it is now second only to the AIDS-related neoplasm, Kaposi's sarcoma. Although survival has improved, young men still die from this neopl | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| MAYO CLINIC JACKSONVILLE (A NONPROFIT CORPORATIO | $152,867 | Grant | Trans-NIH Recovery Act Research Support: Using gene array analysis of patient matched normal renal and clear cell renal cell carcinoma (ccRCC) tissues, our original observation showed loss of the type III TGFbeta receptor (TBR3) in patients diagnosed with ccRCC. Based upon this observation, we e | Health and Human Services, Department of / National Institutes of Health | 9/02/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $166,326 | Grant | Trans-NIH Recovery Act Research Support: This supplement will enhance completion of project aims for a U.S. prospective birth cohort investigating early life factors and breast cancer risk (R01CA104842-05, Early Determinants of Mammographic Density). Our study is one of the few studies in the wo | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $198,711 | Grant | Trans-NIH Recovery Act Research Support: This award was provided to supplement an ongoing research project aimed at finding out why individuals with a personal history of nonmelanoma skin cancer (NMSC) have a heightened risk of developing subsequent cancers other than NMSC. The ARRA funding wil | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| MARSHFIELD CLINIC | $44,249 | Grant | Trans-NIH Recovery Act Research Support: Title: Childhood Overweight in the Heartwatch Cohort: We propose a pilot follow-up to the 1982 Heartwatch Study, a cross-sectional study in Marshfield, WI of cardiovascular disease (CVD) risk factors in 3106 children. Marshfield is unique in that it is | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $20,434 | Grant | Trans-NIH Recovery Act Research Support: Molecular Basis of Infectivity of Brugia malayi microfilariae | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| WESTERN WASHINGTON UNIVERSITY | $39,862 | Grant | Trans-NIH Recovery Act Research Support: This award supports summer undergraduate research experiences that will encourage students to ursue research careers in the health sciences. Research experience is critical in the development of a science educated individual about to enter the health sci | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| TRANSLATIONAL GENOMICS RESEARCH INSTITITUE, THE | $118,353 | Grant | Trans-NIH Recovery Act Research Support: Prostate cancer is the most common malignancy diagnosed in African American men. Incidence and mortality rates are disproportionately higher among African American men when compared to Caucasian men in the US. The specific factors influencing this dispa | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF ARIZONA | $175,489 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this supplement is to accelerate the tempo of scientific research on the currently funded parent grant. To this end, research personnel will be added to the current investigator team, an investment that will further accelerate the pace at w | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| OREGON STATE UNIVERSITY | $294,836 | Grant | Trans-NIH Recovery Act Research Support: Prostate cancer is the most frequently diagnosed non-cutaneous cancer, and is the second leading cause of cancer death in American men. The precise etiologic factors that initiate and enhance the progression of prostate cancer remains unknown, but epigene | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | $171,293 | Grant | Trans-NIH Recovery Act Research Support: One of the molecules causally linked to cancer is the transcription factor STAT3. STAT3 is a member of the family of Signal Transducers and Activators of Transcription and is activated by specific tyrosine phosphorylation. The activity of STAT3 is normall | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $463,376 | Grant | Trans-NIH Recovery Act Research Support: This submission is in response to NOT-OD-09-058., NIH Announces Availability of Recovery Act Funds for Competitive Revision Applications. Our previous study, Healthy Directions (HD1) evaluated an intervention designed to reduce multiple risk factors for c | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $42,826 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): A mammary cancer resistance modifier at the McsSa locus has been localized to an approximate 11.0 Kb region on rat chromosome 5. McsSa was shown to be a compound locus consisting of two component sub-loci Mcs5a1 (32 K | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $261,811 | Grant | Trans-NIH Recovery Act Research Support: Implementing Systemic Interventions to Close the Discovery-Delivery Gap The Community Clinical Oncology Program (CCOP) plays an essential role in the National Cancer InstituteG??s (NCI) efforts to increase enrollment in clinical trials. The community-base | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $194,600 | Grant | Trans-NIH Recovery Act Research Support: Tumors are known as wounds that do not heal - implying that cells involved in angiogenesis and injury response, such as endothelial cells and fibroblasts, have a prominent role in the progression, growth and spread of cancers. Our knowledge regarding the | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $358,892 | Grant | Trans-NIH Recovery Act Research Support: In our parent grant, we proposed to use mass spectrometry to create proteomic profiles of plasma samples from lung cancer cases and controls in order to determine whether this information could be used to classify individuals as healthy or diseased with a | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF ILLINOIS | $192,580 | Grant | Trans-NIH Recovery Act Research Support: The primary purpose of this award was to stimulate basic biological research on cancer. The award supports the hiring of a new graduate student, Yuka Shimizu, and the purchase of laboratory equipment. It is anticipated that the award will lead to the publ | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON | $99,940 | Grant | Trans-NIH Recovery Act Research Support: The vascular endothelium functions both as a barrier and as a targeting site during development and metastasis of breast tumors. The hypothesis for studies in our application is that novel nanovectors to capture proteins associated with angiogenic blood v | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $330,713 | Grant | Trans-NIH Recovery Act Research Support: Fatty acids synthesis occurs at very high rates in tumor tissues, as first demonstrated more than half a century ago. Importantly, 14C glucose incorporation studies have shown that in tumor cells almost all fatty acids derive from de novo synthesis despit | Health and Human Services, Department of / National Institutes of Health | 9/02/2009 |
| NEW YORK UNIVERSITY (INC) | $138,318 | Grant | Trans-NIH Recovery Act Research Support: NON PROTEOLYTIC INTERACTIONS OF TIMP-2 AND MT1-MMP - The invasion-promoting, tumorigenic membrane-type 1 matrix metalloproteinase (MT1-MMP, a transmembrane proteinase with extracellular catalytic, hemopexin (PEX) and hinge domains, and a short cytoplasmic | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $68,686 | Grant | Trans-NIH Recovery Act Research Support: This application requests renewal of a NIDA-sponsored MERIT Award as a R01. The overall goal is to under- stand why individuals differ in cocaine-induced activation and, specifically, i) how the dopamine (DA) trans- porter (DAT) contributes to this differ | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $42,820 | Grant | Trans-NIH Recovery Act Research Support: The core idea of this proposal is that: (a) substances released by neurons trigger the activation of glia, & (b) this glial activation, in turn, leads to the release of glial products that induce & maintain pain facilitation. It is clear from prior studie | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| ALBERT EINSTEIN HEALTHCARE NETWORK | $28,300 | Grant | Trans-NIH Recovery Act Research Support: equipment grant | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $30,241 | Grant | Trans-NIH Recovery Act Research Support: The objectives of this proposal are to determine neural substrates in the rodent hindbrain through which gustatory stimuli guide ingestive behavior. The regulation of ingestive behavior is exceedingly complex, involving widespread regions of the central n | Health and Human Services, Department of / National Institutes of Health | 8/12/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $339,963 | Grant | Trans-NIH Recovery Act Research Support: The long term objective of the research is to understand the nature of aphasic impairments in sentence comprehension, in particular the use of syntactic structure to determine sentence meaning, and the way the processes involved in sentence comprehension | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $182,488 | Grant | Trans-NIH Recovery Act Research Support: The goal of our research program is to understand the brain mechanisms that underlie normal and disordered speech production. The DIVA neural network model of speech production and acquisition plays a central role in this pursuit. The RO1 G?Neural Modelin | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| BAYLOR COLLEGE OF MEDICINE | $162,354 | Grant | Trans-NIH Recovery Act Research Support: Funding for an administrative supplement is requested to carry out next generation sequencing of regions containing nonsyndromic hearing impairment (NSHI) loci in order to identify the phenotype causing gene. The last specific aim (3) of the parent grant | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $54,466 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The long-term goals of this work are to understand the molecular signaling pathways involved in the development and regeneration of inner ear sensory and neuronal populations. The studies done during the initial grant | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF PITTSBURGH THE | $234,240 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this ACC and accompanying equipment supplement (EQ) is to modernize an 11-year old custom-build setup for the mapping of functional connectivity in brainstem slices (glutamate uncaging system) and to request funds to employ a post-doc | Health and Human Services, Department of / National Institutes of Health | 7/10/2009 |
| NORTHWESTERN UNIVERSITY | $194,683 | Grant | Trans-NIH Recovery Act Research Support: The administrative supplement request will be used to add new professional staff, specifically a recent biology graduate working as a Research Technologist, will carry out these additional experiments, and the additional funds will be used to cover cost o | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF ROCHESTER | $274,894 | Grant | Trans-NIH Recovery Act Research Support: Cognitive skills and their underlying brain organization are not fixed but can be shaped by the experience of the individual. The extent of such experience-dependent plasticity provides valuable information about the ability of the nervous system to reorg | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF ARIZONA | $181,016 | Grant | Trans-NIH Recovery Act Research Support: Children with specific language impairment (SLI) constitute the single largest group of developmental communication disorders with a prevalence rate of between 7 and 13% (depending on how the disorder is defined). Therefore, the societal cost of treating | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $97,458 | Grant | Trans-NIH Recovery Act Research Support: The long term goal of this research program is to elucidate both the normal role of non-auditory inputs to the cochlear nucleus (CN), and how alterations of these inputs after deafness may lead to a re-organization of bimodal interactions that result in t | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| MASSACHUSETTS EYE AND EAR INFIRMARY & PHYSICIAN STAFF, INC. | $189,240 | Grant | Trans-NIH Recovery Act Research Support: Bilateral cochlear implants: physiology and psycholphysics This administrative supplement requests the hiring of a postdoctoral fellow in order to investigate the effect of binaurally-coherent jitter on neural ITD sensitivity in bilaterally implanted deaf | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $641,165 | Grant | Trans-NIH Recovery Act Research Support: This revision application proposes to use gain-of-function approaches to define the role of Eya1 in regulating hair cell differentiation program, which is not proposed in the parent grant. In the mammalian auditory system, degeneration of the sensory hai | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $546,488 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Acute otitis media results from a complex interplay of host defenses, environmental factors, and virulence characteristics of bacteria. Previous studies suggest that non-typeable Haemophilus influenza (NTHi), an import | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF KENTUCKY | $74,852 | Grant | Trans-NIH Recovery Act Research Support: The sensory neurons of the olfactory epithelium can be regenerated even if they are completely eliminated. This capacity lasts throughout the life of the animal and is of significant interest for both basic and applied neuroscience research. Its mechanism | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF CHICAGO, THE | $188,261 | Grant | Trans-NIH Recovery Act Research Support: Auditory neurons are characterized by their receptive field properties, which describe the organization of parameters such as frequency and amplitude of stimuli that the neurons respond to. Receptive fields are relatively better described for neurons at l | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| THE JACKSON LABORATORY | $197,695 | Grant | Trans-NIH Recovery Act Research Support: The ability of healthy individuals to walk upright and maintain balance is controlled by the brain and by signals that it receives from within the inner ear's vestibular (balance) system. In the proposed experiments, the Principal Investigator aims to ide | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $216,155 | Grant | Trans-NIH Recovery Act Research Support: The estimated risk for language impairment (LI)in monolingual English speaking children is about 7%. A model for identifying language impairment, referred to as the EpiSLI system (Tomblin, Records, & Zhang, 1996), yields relatively high levels of specific | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $192,316 | Grant | Trans-NIH Recovery Act Research Support: This supplement requests funds to accelerate the study of the functional recovery of olfactory sensory neurons in the adult mouse nervous system after massive neuronal loss and subsequent regeneration. The mammalian olfactory system has the remarkable cap | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $157,265 | Grant | Trans-NIH Recovery Act Research Support: Otitis media is one of the most common causes for visits to the emergency room and the second ranking for visits to a physician's office in the United States (>20 million visits per year), costing the nation 4- 5 billion dollars annually. By three years o | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $133,760 | Grant | Trans-NIH Recovery Act Research Support: The taste periphery comprises a distributed array of taste buds innervated by distinct cranial nerves. In recent years, theories of the embryonic development of this system have undergone radical revision. Previously, taste buds were thought to be induced | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| SOUTHERN ILLINOIS UNIVERSITY | $38,036 | Grant | Trans-NIH Recovery Act Research Support: Chronic tinnitus is a phantom auditory sensation experienced by up to 15% of the population. Between 2 and 10% of the tinnitus population typically experience a continuous high frequency ringing or hiss sufficiently loud to impact severely on their qualit | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, THE | $169,320 | Grant | Trans-NIH Recovery Act Research Support: Human Papillomavirus Infection and Expression of COX-2 This supplement will permit us to pursue in more depth the impact of a new result that we have found during the current study on the parent grant. We have discovered that patients with Recurrent Resp | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $183,285 | Grant | Trans-NIH Recovery Act Research Support: The long term goals of our laboratory are to understand the molecular mechanisms responsible for cell fate specification and sensory patch formation in the developing mammalian inner ear. Progress toward understanding these essential aspects of inner ear | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| ROCKEFELLER UNIVERSITY FACULTY AND STUDENTS CLUB INC, THE | $159,506 | Grant | Trans-NIH Recovery Act Research Support: The preliminary data generated by the parent grant led to the hypothesis that DEET is a competitive antagonist of certain OR/OR83b complexes, but that its efficacy depends strongly on subunit composition. A second hypothesis is that novel antagonists gene | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF KENTUCKY | $180,694 | Grant | Trans-NIH Recovery Act Research Support: The goal of this ARRA supplement is to obtain resources that would allow us to follow regeneration of tip links in a live mammalian hair cell in real time. The parent grant (R01 DC008861) proposed this study as a part of Specific Aim #3, but using scanni | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $201,769 | Grant | Trans-NIH Recovery Act Research Support: The objective of the parent grant is to identify the pheromone ligands, responding sensory neurons, and necessary neuronal circuits that mediate a defined social behavior in the mouse. Social behavior in rodents, like humans, is plastic; the age and gende | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $318,666 | Grant | Trans-NIH Recovery Act Research Support: The studies described in this proposal extend our current investigation on the role of Cdt as a putative virulence factor to a consideration of its utility as a potential therapeutic agent for treating certain types of cancer with defects in the PI-3K/PIP | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $217,883 | Grant | Trans-NIH Recovery Act Research Support: Patients with defective enamel often have prolonged clinical treatments, pain and social anxiety because of the appearance of their teeth. This proposal represents a collaborative effort between clinical and basic science researchers, with the goal of pla | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $13,692 | Grant | Trans-NIH Recovery Act Research Support: Cleft palate represents one of the major groups of congenital birth defects in the human population. Despite recent advancements in medical intervention, babies born with cleft palate often suffer multiple handicaps that significantly compromise the quali | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| NEW YORK UNIVERSITY (INC) | $99,000 | Grant | Trans-NIH Recovery Act Research Support: Fibroblast growth factor receptors (FGFRs) play essential roles in human development and metabolism. The overall aim of this application is to understand how the activity of FGFRs is regulated and to unveil the mechanisms by which naturally occurring pat | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC. | $123,939 | Grant | Trans-NIH Recovery Act Research Support: Out of 290 million dental restorations placed/year in the U.S., 200 million are replacements for failed restorations. This emphasis on replacement therapy is expected to grow as the public's concern regarding mercury and dental amalgam forces dentists to | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $454,821 | Grant | Trans-NIH Recovery Act Research Support: Obesity affects over 1 billion adults and 17.6 million children under 5 years of age. Obesity is known to result in dysregulation of the innate immune response to infection. While the molecular mechanism that underlies this immune/inflammatory-metabolic l | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF IOWA, THE | $99,348 | Grant | Trans-NIH Recovery Act Research Support: Calcitonin gene-related peptide (CGRP) has been implicated in craniofacial pain and headache by virtue of its expression in the trigeminal ganglion and roles in neurogenic inflammation and nociception. In particular, CGRP levels are elevated in migraine, | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF ILLINOIS | $19,939 | Grant | Trans-NIH Recovery Act Research Support: This award was intended to support summer research employment for high school, predental and dental ststudents. Students would get an experience in a modern research laboratory that might allow them to consider a career in research and also provide jobs f | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| CALIFORNIA INSTITUTE OF TECHNOLOGY | $29,853 | Grant | Trans-NIH Recovery Act Research Support: This grant provides summer research experience for 3 undergraduate students in health-related scientific research. | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $410,200 | Grant | Trans-NIH Recovery Act Research Support: The proposed competitive revision represents the natural extension of R01 DE017954 entitled 'Glycosylation and Function of an Oral Streptococcal Adhesin'. This parent grant studies an important streptococcal adhesin Fap1 of Streptococcus parasanguinis we | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) | $87,085 | Grant | Trans-NIH Recovery Act Research Support: Localized aggressive aerodonetics (LAP) affects approximately 70,000 U.S. children, largely from underserved groups. The goal of the parent proposal is to identify microbial and host factors indicative of LAP risk. The administrative supplement will focus | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF LOUISVILLE | $388,219 | Grant | Trans-NIH Recovery Act Research Support: This Competitive Revision application proposes an additional Specific Aim for the original R01 project of the same title. The long term goal of our project is to define the development of signaling networks that induce differentiation of cells into mature | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| THE VANDERBILT UNIVERSITY | $23,044 | Grant | Trans-NIH Recovery Act Research Support: Prostaglandin E2 (PGE2) regulates blood pressure, where it can exert either vasopressor or vasodepressor effects. These physiologically opposing effects can be explained in part by the existence of four PGE2 receptors, designated the E-Prostanoid (EP) rec | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | $100,000 | Grant | Trans-NIH Recovery Act Research Support: Lipid Transport in the Intestine Fatty acids (FA) and monoacylglycerol (MG) are the primary hydrolytic products of dietary triacylglycerol (TG). Substantial gaps remain in our understanding of the basic mechanisms of MG and FA assimilation by the intestin | Health and Human Services, Department of / National Institutes of Health | 8/26/2009 |
| CHILDREN'S RESEARCH INSTITUTE | $172,000 | Grant | Trans-NIH Recovery Act Research Support: The overall hypothesis of the currently funded grant is G?deficiency of the D5 dopamine receptor (D5R) leads to increased angiotensin (Ang) type 1 receptor (AT1R) expression, sodium sensitivity, and hypertensionG?. This hypothesis has been proved to be co | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| GEORGIA HEALTH SCIENCES UNIVERSITY RESEARCH INSTITUTE, INC. | $218,496 | Grant | Trans-NIH Recovery Act Research Support: Supplemental funding will support a new specific aim that will allow us to extend our studies on adrenal zonation into transgenic mouse models. The human adrenal cortex can be divided into distinct zones that have both morphologic and biochemical differe | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $99,875 | Grant | Trans-NIH Recovery Act Research Support: Phosphatidylcholine transfer protein (PC-TP, a.k.a. StarD2) is a highly specific intracellular lipid binding protein with accentuated expression in liver and other oxidative tissues, including brown fat, heart, and skeletal muscle. Using PC-TP-deficient ( | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| UNIVERSITY OF FLORIDA | $8,538 | Grant | Trans-NIH Recovery Act Research Support: This award is for a summer student supplement. I recruited one undergraduate student this summer, Michael H. Rosenberg, who is working on the specific aims outlined in the proposal. The purpose of this award is to provide training in molecular genetics | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| THE VANDERBILT UNIVERSITY | $21,086 | Grant | Trans-NIH Recovery Act Research Support: The mechanism that allows steroid receptors to control tissue-specific and cell-specific gene expression is fundamental to understanding how an endocrine tissue targets hormone action at distant sites. Clearly, the steroid receptor will be required but t | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| UNIVERSITY OF CHICAGO, THE | $446,024 | Grant | Trans-NIH Recovery Act Research Support: The metabolic syndrome (MetS) is a cluster of phenotypes that includes type 2 diabetes (T2D), obesity, hypertension, and dyslipidemia. These phenotypes show dramatic increases in prevalence in populations that recently switched from a traditional subsiste | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $100,000 | Grant | Trans-NIH Recovery Act Research Support: The pathophysiology of diabetic neuropathy is poorly understood. We reported previously that sera from patients with type 2 diabetes mellitus with neuropathy induced programmed cell death (PCD) in cultured human neuroblastoma cells via an autoantibody-med | Health and Human Services, Department of / National Institutes of Health | 9/10/2009 |
| CORNELL UNIVERSITY, INC | $100,000 | Grant | Trans-NIH Recovery Act Research Support: This extends ongoing research focused on understanding the role of nuclear folate metabolism in folate-mediated one-carbon metabolism and folate-associated pathologies. The proposed studies will enable us to follow up on a recent novel discovery that bot | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| THE WASHINGTON UNIVERSITY | $99,999 | Grant | Trans-NIH Recovery Act Research Support: CD36 is a multifunctional membrane protein we identified in 1993 as a facilitator of long-chain fatty acid (FA) uptake. This role of CD36 is now supported by a wealth of in vivo evidence obtained by us and by others. This grant was initially submitted to | Health and Human Services, Department of / National Institutes of Health | 8/21/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $156,083 | Grant | Trans-NIH Recovery Act Research Support: The proposed program will provide a genuine, goal-oriented research experience for high school students and teachers, introduce students to a potential career path in biomedical science, extablish relationships with local high school science teachers that | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $110,601 | Grant | Trans-NIH Recovery Act Research Support: Project Narrative Our supplement will address the intent of the American Recovery and Reinvestment Act of 2009 regarding our parent proposal to better understand the pathophysiology of acute kidney injury and identify novel therapeutic options. The upgrad | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $79,028 | Grant | Trans-NIH Recovery Act Research Support: To characterize phenotypes of TLR4 transgenic mice on weight gain, food intake, insulin and glucose tolerance test, adiposity, and the expression of pro-inflammatory marker genes in adipose tissue. | Health and Human Services, Department of / National Institutes of Health | 8/24/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $64,158 | Grant | Trans-NIH Recovery Act Research Support: The long-term objective of our laboratory is to understand changes in gene expression and regulation that occur during insulin resistance and diabetes which permit excessive SMC activation. We recently reported that overexpression of the cAMP Response Ele | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| WASHINGTON UNIVERSITY, THE | $48,391 | Grant | Trans-NIH Recovery Act Research Support: The mucosal immune system is a complex network of lymphoid compartments whose function is to protect against invading pathogens. The immune responses generated by the mucosal immune system must be tightly controlled, as inappropriate responses can damage | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| THE WASHINGTON UNIVERSITY | $276,439 | Grant | Trans-NIH Recovery Act Research Support: 30% of women suffer from frequent recurrent infections. The goal of this project is to improve understanding of the pathogenic mechanisms underlying UTIs, resulting in new diagnostics and novel approaches to prevention and treatment, more tailored therapi | Health and Human Services, Department of / National Institutes of Health | 11/20/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $45,695 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The small intestinal epithelium is organized into flask-like glands (crypts) that contain intestinal stem cells and finger-like projections (villi) covered by differentiated cells. A constant process of cell division, | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| THE VANDERBILT UNIVERSITY | $100,000 | Grant | Trans-NIH Recovery Act Research Support: Trafficking events regulating vesicle targeting to the apical membrane are regulated by a number of Rab small GTPases including Rab11a, Rab8a and Rab10. The results from our present RO1 have demonstrated that class V myosin motors can associate will all t | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $97,731 | Grant | Trans-NIH Recovery Act Research Support: We will establish the qualitative and quantitative potential of stem cells (SC) and committed progenitor cells of hematopoietic tissue (HSC) for the repair of damage to epithelial tissues. These studies are designed to examine the mechanisms responsible f | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| EMORY UNIVERSITY | $99,002 | Grant | Trans-NIH Recovery Act Research Support: Our long-term goal of the parent grant is to understand the cellular signaling mechanisms in intestinal epithelia with an emphasis on how protein-protein interaction affects the specificity and efficiency of signaling processes. Lysophosphatidic acid (LPA | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| MICHIGAN STATE UNIVERSITY | $100,000 | Grant | Trans-NIH Recovery Act Research Support: In this proposal, we describe the development of an analytical system that will enable the elucidation of the role of red blood cells (RBCs) in complications resulting from type II diabetes. Specifically, using a lab on a chip approach, we propose to exam | Health and Human Services, Department of / National Institutes of Health | 6/22/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $443,515 | Grant | Trans-NIH Recovery Act Research Support: In response to notice NOT-OD-09-058 (NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications) and requests a competitive supplement under ARRA 2009. Muscle wasting and insulin resistance in those patients infected with H | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| CHILDRENS HOSPITAL OF PHILADELPHIA | $100,000 | Grant | Trans-NIH Recovery Act Research Support: Skeletal growth is characterized by gender-, maturation-, and race- specific increases in cortical dimensions and trabecular volumetric bone mineral density (vBMD). Children with Crohn disease (CD) have numerous risk factors for impaired bone accrual, inc | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $99,992 | Grant | Trans-NIH Recovery Act Research Support: This is a supplement request to grant DK073955 (Role of oleoylethanolamide in the control of food intake), which tests the hypothesis that the lipid mediator oleoylethanolamide (OEA) contributes to the physiological induction of satiety. In the initial fu | Health and Human Services, Department of / National Institutes of Health | 7/31/2009 |
| ST LUKE'S-ROOSEVELT HOSPITAL CENTER | $730,010 | Grant | Trans-NIH Recovery Act Research Support: Obesity, continues to increase in prevalence world wide. A sizable subset of obese subjects has binge eating disorder (BED), and ingest large meals, without the purging of bulimia nervosa. BED, the most common eating disorder, causes much suffering and di | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $34,751 | Grant | Trans-NIH Recovery Act Research Support: This grant provided a summer research experience for 2 high school students and one science educator. The field work for this project is complete and analyses of the data are under way. A conference abstract reporting on the project and its results was | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $227,693 | Grant | Trans-NIH Recovery Act Research Support: Finally, we have started to evaluate the role of CtIP in ATM activation. We have shown that CtIP influences DNA resection at double-strand breaks. We now find that CtIP depletion does not abrogate the loading of the MRN complex to DSBs-containing chromati | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $1,230,625 | Grant | Trans-NIH Recovery Act Research Support: Controversy exists among scientists, policy makers, and the public/media regarding health risks and benefits of fish intake in adults. Evidence indicates that long-chain n-3 fatty acids (n-3 FA) reduce risk of cardiovascular disease (CVD). Conversely, exp | Health and Human Services, Department of / National Institutes of Health | 9/26/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $289,022 | Grant | Trans-NIH Recovery Act Research Support: Ambient air pollution correlates with cardiovascular mortality and morbidity and is a cause of systemic inflammation. Inflammation is the hallmark of atherosclerosis, which is the primary underlying pathophysiology of cardiovascular diseases (CVD). Signif | Health and Human Services, Department of / National Institutes of Health | 9/06/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $529,239 | Grant | Trans-NIH Recovery Act Research Support: This project pursues the hypothesis that lifetime cumulative exposure to ambient air pollution is associated with sonographically measured carotid intima-media thickness (CIMT) at age 18-20. CIMT is an established marker of subclinical atherosclerosis - t | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $457,994 | Grant | Trans-NIH Recovery Act Research Support: Environmental Arsenic and Diabetes Mellitus ARRA This is an Administrative Supplement to the current NIH grant No. 1R01ES015326-01A2 (!Environmental Arsenic and Diabetes Mellitus!). Inorganic arsenic (iAs) is a common drinking water contaminant. Consumpt | Health and Human Services, Department of / National Institutes of Health | 9/06/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $693,000 | Grant | Trans-NIH Recovery Act Research Support: This application is in response to NOT-OD-09-058, NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications. Different individuals exposed to the same environmental agent often respond differently due to additional factors | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| TEXAS A&M UNIVERSITY SYSTEM,THE | $281,342 | Grant | Trans-NIH Recovery Act Research Support: Congenital defects remain the greatest contributor to infant mortality; yet, the causes for the majority of these defects are either unknown or poorly understood. Amine- and amide-containing (nitrosatable) drugs and other compounds react with nitrite in t | Health and Human Services, Department of / National Institutes of Health | 9/06/2009 |
| UNIVERSITY OF PITTSBURGH THE | $320,902 | Grant | Trans-NIH Recovery Act Research Support: Title: The contribution of DNA interstrand crosslinks to Aging RO1 ES016114 This is a supplement to an existing RO1 from NIEHS. The purpose of this project is to test the hypothesis that the cellular response to crosslinking agents is determined at leas | Health and Human Services, Department of / National Institutes of Health | 9/06/2009 |
| UNIVERSITY OF MARYLAND BALTIMORE COUNTY | $204,954 | Grant | Trans-NIH Recovery Act Research Support: The supplemental effort is aimed at enhancing the original research objective #5 and accelerate the pace of science in understanding how in-situ amendment technology works by tracking the fate of PCB sorption and biodegradation processes simultaneously. | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $140,650 | Grant | Trans-NIH Recovery Act Research Support: Macular degeneration - the loss of central vision due to retinal damage - is the leading cause of visual impairment in the developed world, affecting more than 1.6 million Americans over the age of 50. Individuals with total loss of central vision must l | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| WAKE FOREST UNIVERSITY | $354,948 | Grant | Trans-NIH Recovery Act Research Support: One of the brain's remarkable capabilities is the ability to integrate information from very different sources to produce a coherent picture of the external world. This enhances its ability to detect, localize and identify environmental events. There is n | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| CALVIN COLLEGE | $8,243 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this project (R01 EY018100) is to show that the relatively high K+ concentration in the tears (20-25 mM) protects the corneal epithelium from adverse effects of ambient UV-B. Exposure of cells to UV-B activates K+ channels allowing los | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $156,179 | Grant | Trans-NIH Recovery Act Research Support: We are not aware of the small eye movements that, during visual fixation, keep the retinal image continually in motion. These movements tend to be neglected by studies of visual perception. Yet, a large body of evidence indicates that fixational eye movem | Health and Human Services, Department of / National Institutes of Health | 8/19/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $85,500 | Grant | Trans-NIH Recovery Act Research Support: The objective of this program is to develop novel electroactive polymer (EAP) actuator technology for refreshable full page Braille display and graphic display. Built upon the experiences and successful foundation laid by a R21 program, the goal of this w | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF PRINCETON UNIVERSITY, THE | $457,756 | Grant | Trans-NIH Recovery Act Research Support: Messenger RNA (mRNA) localization has emerged as an important mechanism for generating asymmetric protein distributions that promote morphological and functional cell polarization during development. Polarized cellular functions like motility in fibroblas | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $177,500 | Grant | Trans-NIH Recovery Act Research Support: The first goal of the Recovery Act Supplement is to retain a skilled Research Associage and a very talented Postdoctoral Fellow/Instructor who are essential to my research program. The second is to provide the time and resources necessary to submit a stre | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| CALIFORNIA INSTITUTE OF TECHNOLOGY | $655,307 | Grant | Trans-NIH Recovery Act Research Support: Synthetic protein families powerfully complement natural genetic diversity in efforts to understand fundamental sequence-structure-function relationships. We propose to use a unique family of chimeric cytochrome P450s made by structure-guided recombinati | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| SAINT LOUIS UNIVERSITY | $84,530 | Grant | Trans-NIH Recovery Act Research Support: Currently there is a lack of technology to integrate in vitro cell culture systems that realistically mimic in vivo environments with an analysis system that can discretely analyze a wide variety of products released from a confluent layer of cells. The g | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| MOREHEAD STATE UNIVERSITY | $37,000 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION: This proposal accomplishes the AREA program objectives of: 1) supporting meritorious research; 2) exposing undergraduates to research; and 3) strengthening the research environment in non-research intensive universities. The general goal o | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| MARY BALDWIN COLLEGE | $72,696 | Grant | Trans-NIH Recovery Act Research Support: Steroid hormones are responsible for many observed sex differences in brain and behavior in a variety of species, including humans. The female Asian musk shrew (Suncus murinus) is an insectivore that differs from most other mammals in its 1) lack of behav | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| COLLEGE OF WILLIAM & MARY, THE | $28,600 | Grant | Trans-NIH Recovery Act Research Support: The goal of this Administrative Supplement Proposal is the completion of several additional studies, that in conjunction with the original proposal, will provide a better understanding of how the neuropeptide calcitonin gene-related peptide (CGRP) contrib | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | $542,808 | Grant | Trans-NIH Recovery Act Research Support: The Hemodialysis Fistula Maturation Consortium (HFMC) will conduct a prospective multi-center observational cohort study investigating factors associated with the failure of arteriovenous fistulas (AVFs) to mature. The Data Coordinating Center (DCC) will | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $200,850 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION, OVERALL (provided by applicant): The University of Michigan is ideally poised to house a MAPP Discovery Site. The faculty of the Chronic Pain and Fatigue Research Center (CPFRC) are internationally known for translational research in fibromya | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE | $227,835 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this project is to accelerate the development of the betamethasone Uniject device, an innovative technology that simplifies the administration of intra-muscular drugs. The betamethasone Uniject device will be used as part of a multi-compone | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| MOREHOUSE SCHOOL OF MEDICINE, INC., THE | $280,000 | Grant | Trans-NIH Recovery Act Research Support: CHE Objective 1: The CHE will help to identify and implement (through training of partners) evidence-based interventions that can be implemented by community partners. The primary cancer areas for implementation of evidence-based projects include breast | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| NORTHWESTERN UNIVERSITY | $66,719 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement would be used to provide summer research experience to four undergraduates in 2009 and six in 2010. Expansion would also keep pace with increased student interest, as the level of applications for INN summer programs was hig | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $54,808 | Grant | Trans-NIH Recovery Act Research Support: The purpose of the administrative supplement was to employ a postdoctoral researcher to help accelerate the work on Cores 1, 2, and 4 of our parent grant (U54EB007959). The main goal of the U54 Point-of-Care Technologies Center is to develop new point-of- | Health and Human Services, Department of / National Institutes of Health | 7/30/2009 |
| UNIVERSITY OF WASHINGTON | $296,314 | Grant | Trans-NIH Recovery Act Research Support: Two goals of the national consortium of medical research institutions funded by the NCRR CTSA's are to improve the conduct of biomedical research across country and reduce the time it takes for laboratory discovery to become treatments for patients. Bar | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| NORTHWESTERN UNIVERSITY | $589,242 | Grant | Trans-NIH Recovery Act Research Support: The goal of this CTSA supplemental award is to create, evaluate and disseminate new, durable and readily-accessible on-line learning resources to enhance essential skills needed to perform transdisciplinary, team-based basic and clinical translational res | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $221,596 | Grant | Trans-NIH Recovery Act Research Support: In vivo analysis of cerebellar circuitry has focused almost exclusively on Purkinje cells, identified by their iconic patterns of complex and simple spikes (CSs and SSs). However, views of cerebellar function based exclusively on the physiology of Purkinj | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF WASHINGTON | $88,363 | Grant | Trans-NIH Recovery Act Research Support: Our current parent grant, which has just begun a 4-year cycle, has two broad themes: first, to understand the mechanisms governing the regulation of origins of chromosomal DNA replication, and second, to understand the interplay between origin activity an | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $141,142 | Grant | Trans-NIH Recovery Act Research Support: The cytochrome bc1 complex is an energy-transducing enzyme that participates in cell respiration in oxygen utilizing eukaryotic cells and is located in the inner mitochondrial membrane. A similar bc1 complex is located in the plasma membrane of many bacte | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $172,156 | Grant | Trans-NIH Recovery Act Research Support: This supplement to GM027870 requests funding for one fulltime research specialist +?:technician+?; dedicated to obtaining protein preparations for structural determination. In addition, equipment is requested for growth of the cultures necessary as starti | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $84,750 | Grant | Trans-NIH Recovery Act Research Support: This project will clarify the mechanisms used by alkaliphilic Bacillus for the two processes that move protons inward at high external pH: how extremely robust proton-coupled oxidative phosphorylation (OXPHOS) occurs under conditions in which the chemiosm | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK INC | $141,096 | Grant | Trans-NIH Recovery Act Research Support: Funds from this administrative supplement continue to be used to support senior postdoctoral fellow Emanuel Rosonina, as proposed in the supplement application. Dr. Rosonina is analyzing mutants of the yeast exoribonuclease Rat1 by chromatin immunoprecip | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| EMORY UNIVERSITY | $226,774 | Grant | Trans-NIH Recovery Act Research Support: Title: Ubiquitin-dependent Proteolysis: Specificity and Mechanism. Post-translational ubiquitination of proteins generates a signal that targets the modified protein to multiple cellular fates. Polyubiquitin binding proteins are necessary to couple the p | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $407,820 | Grant | Trans-NIH Recovery Act Research Support: This ARRA supplement will support screening for inhibitors of a particular gene product i order the find lead compounds new class of antibiotic. The gene, found in the genome of every bacterium in the world, is know a ybeY in E. coli and is a member of th | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF PITTSBURGH THE | $136,350 | Grant | Trans-NIH Recovery Act Research Support: The goal of this supplement activity is to identify the functional domains of PcrA that are critical for the growth and viability of Staphylococcus aureus. PcrA is an essential protein in S. aureus that is required for both cell growth and the replicatio | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $298,300 | Grant | Trans-NIH Recovery Act Research Support: Our goal is to find inhibitors of the E. coli RecBCD enzyme, one of the subjects of the parent grant. Inhibitors would allow us to study in greater detail the mechanism of this complex enzyme required for repair of DNA double-strand breaks; we could use | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $57,445 | Grant | Trans-NIH Recovery Act Research Support: The aim of this project is to understand how bacterial multicomponent monooxygenases activate dioxygen to perform the selective oxidation of hydrocarbons through the synthesis of model compounds and by direct studies of the enzymes. The flagship member of | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| BROWN UNIVERSITY IN PROVIDENCE IN STATE OF RI AND PROVIDENCE PLANTATIONS | $125,431 | Grant | Trans-NIH Recovery Act Research Support: The long term goal in this project remains the elucidation of the structure and function of nicotinic acetylcholine receptors (nAChRs). Classical approaches to discern functionally significant neuronal nAChR subtypes in the central nervous system (CNS) ha | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| WASHINGTON UNIVERSITY, THE | $190,000 | Grant | Trans-NIH Recovery Act Research Support: Microtubule-organizing centers (MTOCs) or centrosomes play important roles in all eukaryotic cells. MTOCs are involved in mitotic spindle organization and in an increasing number of other fundamental cellular processes. Defects in MTOCs contribute to sp | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF ARIZONA | $138,416 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this research is to investigate the intersection of fatty acid/lipoic acid synthesis and RNA processing in mitochondria, which links cellular metabolism to the control of gene expression. Loss of any enzyme in the type II fatty acid b | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $257,773 | Grant | Trans-NIH Recovery Act Research Support: The goal of these studies is to understand the interactions of signaling proteins associated with plasma- lemmal caveolae in vascular endothelial cells, with an ultimate aim of identifying the abnormalities in endothelial signaling that underlie many vasc | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $120,562 | Grant | Trans-NIH Recovery Act Research Support: The administrative supplement will be used to carryout a highly sensitized screen using transgene based RNAi to identify additional genes whose function is required for the development of planar polarity in the Drosophila epidermis. The basic approach of | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| BAYLOR COLLEGE OF MEDICINE | $168,823 | Grant | Trans-NIH Recovery Act Research Support: To determine the role of single-strand break repair in CAG repeat instability in human cells and mice. ABSTRACT The overall goal of our studies is to elucidate the mechanisms responsible for repeat expansions in humans. Our basic approach is to combine th | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF UTAH, THE | $141,577 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The long-term objectives of the proposed research are to understand how specificity is determined within a family of eukaryotic regulatory transcription factors. The ets gene family, which is found throughout the metaz | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF NEW MEXICO | $164,450 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Histone covalent modifications are tightly linked to the regulation of eukaryotic gene expression. Monoubiquitylation of histone H2B (H2Bub) in the budding yeast, Saccharomyces cerevisiae, is associated with transcript | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $258,888 | Grant | Trans-NIH Recovery Act Research Support: Many natural products contain cyclopropane, oxirane, or aziridine groups as key structural elements. These three-membered ring moieties are generally stable despite their considerable ring strain. However, the inherent reactivities of these small rings ca | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF CALIFORNIA, SANTA CRUZ | $69,252 | Grant | Trans-NIH Recovery Act Research Support: Cytokinesis, the final event of the cell cycle, involves actomyosin based constriction of the plasma membrane to produce two daughter cells. Recent studies demonstrate that targeted membrane addition at the cleavage furrow also plays a key role in cytokin | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $229,827 | Grant | Trans-NIH Recovery Act Research Support: Funding is for one primary project and one secondary project that will expand our understanding of growth and differentiation in a S. cerevisiae model system that involves conserved proteins homologous to drug targets. The purpose of the proposed researc | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $148,175 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this proposal is to gain a better understanding of the functions of the Ras related Ral- GTPase family. RalA and RalB have been implicated in diverse cell functions including the control of vesicle sorting, gene expression and cell pro | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $167,511 | Grant | Trans-NIH Recovery Act Research Support: Under the parent grant, we will develop the methods and tools that will profile glycans in human fluids to enable the discovery of markers for diseases. Cancer is a disease known to accompany aberrant glycosylation. Glycoproteins shed by diseased cells | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| LUDWIG INSTITUTE FOR CANCER | $53,471 | Grant | Trans-NIH Recovery Act Research Support: DNA mismatch repair (MMR) plays a number of critical roles in eukaryotic cells including: 1) suppression of mutations that result from misincorportation errors during DNA replication as well as chemical damage to DNA and DNA precursors; 2) repair of mispa | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $108,712 | Grant | Trans-NIH Recovery Act Research Support: The parent grant included within its Specific Aims efforts to compare NMR spin relaxation data and molecular dynamics (MD) simulation results for E. coli and Thermus thermophilus ribonuclease H (RNase H) enzymes. Over the course of the project, these effo | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $71,009 | Grant | Trans-NIH Recovery Act Research Support: Molecular Mechanisms of Signal Transduction by Two-Component Regulatory Systems These ARRA funds are in the form of an administrative supplement to our parent NIH grant. The topic of the parent grant is to understand in detail how a particular type of i | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| RENSSELAER POLYTECHNIC INSTITUTE | $114,000 | Grant | Trans-NIH Recovery Act Research Support: The parent grant focuses on three Kinesin motor proteins to understand their specific roles during mitosis. The supplemental funds will be used to modify the fluorescence microscope to a TIRF fluorescence microscope. | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $183,309 | Grant | Trans-NIH Recovery Act Research Support: The broad, long-term objectives of this research are to elucidate the fundamental principles and mechanisms of hydrogen transfer in enzyme catalysis and to address unresolved issues in biologically important systems. These objectives will be accomplished | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| THE INSTITUTE FOR CANCER RESEARCH | $96,891 | Grant | ARRA - Community Services Block Grant: Kinetic studies involving rapid mixing techniques are a critical component of our NIGMS-sponsored research aimed at understanding fundamental aspects of protein folding, including the structural and dynamic properties of unfolded states and early kinetic | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $58,976 | Grant | Trans-NIH Recovery Act Research Support: Swarming is a widespread mode of surface colonization by flagellated bacteria. It shares features with other surface phenomenon such as biofilm formation and host invasion, and is therefore a particularly relevant model for uncovering and understanding ba | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK INC | $134,950 | Grant | Trans-NIH Recovery Act Research Support: The goal of this research is to develop technology to help clinicians articulate and communicate information needs that arise during clinical practice, and answer their questions in a timely manner consistent with clinical workflow. In our supplement prop | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UMDNJ-ROBERT WOOD JOHNSON MEDICAL SCHOOL | $153,367 | Grant | Trans-NIH Recovery Act Research Support: ARRA Activities Barbara Brodsky GM60048-S1: Collaborative project with Dr. George Makhatadze: Studies on electrostatic interactions within the collagen triple-helix ? A Gly to Ala substitution in type I collagen which leads to a moderate case of Osteoge | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| WASHINGTON UNIVERSITY, THE | $285,238 | Grant | Trans-NIH Recovery Act Research Support: This Competitive Revision Supplement, funded under NOT-OD-09-058, ARRA NIH announcement will expand the scope of our currently funded project R01 GM060494 entitled 'Myosin VI function and mechanism.' Actin structures play many important roles in cells of | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $249,556 | Grant | Trans-NIH Recovery Act Research Support: In all organisms, RNA molecules are needed to translate genes into protein, and to turn specific genes on and off. The malfunction of controlling RNAs has been linked to diseases such as muscular dystrophy, Fragile X mental retardation, and certain tumors | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| HEALTH RESEARCH, INC. | $52,000 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this ARRA award is to enhance the data processing capabilities in the PI?s lab. The lab studies structure and function of cellular protein synthesis machinery, the ribosome. Research work in the lab involves extensive image processing and m | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| BRANDEIS UNIVERSITY | $119,625 | Grant | Trans-NIH Recovery Act Research Support: During the last several years our research program has made signiificant progress in the development and application of cinchona alkaloids as broadly useful chiral base/nucleophilic catalysts for asymmetric synthesis and in the elucidation of catalyst-sub | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $275,846 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of the parental grant (GM61905) is to understand the molecular basis of transport and selective inhibition of the lipid ABC flippase MsbA. We request supplemental funds for two post-doc associates (US citizens) and a Beckman (USA) JA-?26X | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $181,032 | Grant | Trans-NIH Recovery Act Research Support: The gene regulatory mechanisms that program cell differentiation from proliferating precursor cells are fundamentally important for development, tissue homeostasis and cancer. Using the dramatic cellular differentiation program of spermatogenesis as a mo | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF WASHINGTON | $246,635 | Grant | Trans-NIH Recovery Act Research Support: While we know a great deal about genetic and cellular mechanisms of early vertebrate development, we know far less about later processes of organogenesis, and the mechanisms that underlie adult form and its maintenance. Elucidating the mechanisms responsi | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $74,990 | Grant | Trans-NIH Recovery Act Research Support: Functions and regulation of Dbl-family guanine nucleotide exchange factors ARRA Purpose: The award is for the purchase of a state-of-the-art spectrofluorometer for steady-state measurements GTPase activation and deactivation Expected outcome: Requests ha | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF CONNECTICUT | $105,189 | Grant | Trans-NIH Recovery Act Research Support: Alternative splicing is a common mechanism by which eukaryotes regulate gene expression and is the primary means of enhancing the diversity of proteins encoded by the genome. In addition, defects in alternative splicing can result in many human diseases i | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF UTAH, THE | $234,899 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Oxidation reactions are essential for both functional group manipulation and heteroatom introduction in the synthesis of biologically relevant compounds. Newly discovered and significantly improved oxidative processes | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| THE VANDERBILT UNIVERSITY | $314,161 | Grant | Trans-NIH Recovery Act Research Support: This program describes a chemical synthesis route to biologically active natural products. Mitomycin C is a clinically-used small molecule for chemotherapy that functions as a DNA cross-linking agent. No other known chemotherapeutic duplicates this mechan | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| MICHIGAN STATE UNIVERSITY | $105,045 | Grant | Trans-NIH Recovery Act Research Support: Enzymes containing mononuclear non-heme iron sites catalyze a diverse array of reactions that are significant to medicine and to the environment. The studies described in this proposal focus on the largest group of non-heme iron enzymes, the Fe(ll)- and a | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF WASHINGTON | $306,967 | Grant | Trans-NIH Recovery Act Research Support: We are in the second year of a 4-year grant to study the regulation of intestinal CYP3A4 by a vitamin D signaling pathway and the potential role of PXR activation and enhanced vitamin D catabolism in drug induced osteomalacia. The experimental plan descr | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| OKLAHOMA STATE UNIVERSITY | $124,278 | Grant | Trans-NIH Recovery Act Research Support: Lipids, stored as triacylglycerol (TG), play an essential role as reserve of metabolic energy in insects. Utilization of fat body TG stores requires TG hydrolysis (lipolysis). Because fatty acids provide energy to other tissues as well as to the fat body | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $487,500 | Grant | Trans-NIH Recovery Act Research Support: This award is the competitive revision of the grant G?Computational Mapping of Proteins for the Binding of LigandsG?. Mapping methods place molecular probes G?? small molecules or functional groups G?? on the surface of proteins in order to identify the m | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $258,887 | Grant | Trans-NIH Recovery Act Research Support: We will be conducting studies on the visualization and quantification of the assembly, disassembly, and polarity of RecA and Rad51 nucleoprotein complexes; determining how the dynamic behavior of RecA protein is modified by the mediator protein complex, | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| KANSAS STATE UNIVERSITY | $199,725 | Grant | Trans-NIH Recovery Act Research Support: The purpose of the supplement is to enhance the biochemical and biophysical studies on the role of yeast ribosome in start codon selection. Major equipment to be purchased for this purpose includes Beckman Optima Max XP ultraecentrifuge and GE AKTApurifie | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| ROCKEFELLER UNIVERSITY FACULTY AND STUDENTS CLUB INC, THE | $424,241 | Grant | Trans-NIH Recovery Act Research Support: The stable propagation of our genomes requires the accurate segregation of replicated chromosomes and the proper cleavage of a cell into two daughters. These processes depend on the formation a bipolar spindle before anaphase and a central spindle (or mid | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF IOWA, THE | $182,190 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this proposal is to understand the molecular mechanisms that regulate exocytosis in order to comprehend and develop therapies for devastating human diseases in which exocytosis is defective, such as diabetes and polycystic kidney dis | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF NOTRE DAME DU LAC | $336,407 | Grant | Trans-NIH Recovery Act Research Support: Recognition of a peptide/MHC (pMHC) ligand by the ?? T cell receptor (TCR) is required for the development and maintenance of the T cell repertoire and the initiation and propagation of a cellular immune response. Although antigen specificity is a hallmar | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $33,544 | Grant | Trans-NIH Recovery Act Research Support: Nitrogenase is a complex metalloenzyme that catalyzes one of the most remarkable chemical transformations in biological systems: the nucleotide-dependent reduction of atmospheric dinitrogen to bioavailable ammonia. There is an outstanding interest in deco | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $230,776 | Grant | Trans-NIH Recovery Act Research Support: Organs are shaped by the morphogenic activities of cells. Prominent amongst these activities is planar-cell-polarized (PCP) morphogenesis, which is seen within epithelial sheets and epitheliod cell groups. The overall goal of the parent grant is to under | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $44,095 | Grant | Trans-NIH Recovery Act Research Support: Regulation of gene expression by noncoding RNAs (ncRNAs) is an emerging paradigm in biology. ncRNAs regulate a variety of processes, including transcription, translation, RNA modification, mRNA stability, RNA splicing, chromatin structure, and protein sta | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| MAYO CLINIC | $69,332 | Grant | Trans-NIH Recovery Act Research Support: The central importance of the ERBB/RAS signal transduction cascade has been well established in human cancer. Activated ERBB/K-RAS signaling is often associated with the most lethal forms of cancer. The patient genome sequencing projects have recently rev | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| WAKE FOREST UNIVERSITY | $356,655 | Grant | Trans-NIH Recovery Act Research Support: The 3'??5' deoxyribonucleases are essential enzymes in DNA metabolism that catalyze excision of nucleotides from the 3' ends of DNA to prepare these 3' termini for subsequent steps during DNA processing. The long term goal of this project is to understand | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| UNIVERSITY OF FLORIDA | $75,000 | Grant | Trans-NIH Recovery Act Research Support: We have updated the Queuosine (Q) subsystem in the SEED database and analyzed 727 genomes for the presence of tgt, the signature gene of the Q pathway encoding tRNA guanine transglycosylase (TGT), and the precursor biosynthesis genes (queCDEF) [3]. As sho | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF CHICAGO, THE | $115,943 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement grant will provide a timely support for the structural characterization of a human DNA/RNA modification protein ABH3 bound to DNA. ABH3 is a human homologue of E. Coli AlkB. This protein has been identified as a prostate c | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $117,236 | Grant | Trans-NIH Recovery Act Research Support: Although frequently predicted to play critical roles in regulatory control, the nature and identity of functional noncoding sequences require comprehensive investigation. The inability to readily impute the functions of noncoding sequences, or the impact | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| COLORADO STATE UNIVERSITY | $110,250 | Grant | Trans-NIH Recovery Act Research Support: Our overall goal is to elucidate the pathways and mechanisms involved in regulated mRNA stability and post-transcriptional control in general. These processes play a very important role in controlling gene expression related to cell growth and differentia | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $323,160 | Grant | Trans-NIH Recovery Act Research Support: Although the constancy of genetic information is central, genomes are surprisingly unstable. Transposable elements, i.e.discrete DNA segments that can move between many non-homologous positions, are widespread, having been found in virtually all organisms | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE, INC. | $135,110 | Grant | Trans-NIH Recovery Act Research Support: This a Recovery Act Supplement, which will be used to supplement research being carried out under the parent R01 award GM077176 entitled G?Structural Biology of Oxylipin BiosynthesisG?. The major goal of the parent grant is to utilize structure-function s | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| CORNELL UNIVERSITY, INC | $71,277 | Grant | Trans-NIH Recovery Act Research Support: Viruses invade all forms of life, causing diseases in humans including HIV-AIDS. Although the variety of viruses is daunting, all enveloped viruses, including HIV-1 and Rous Sarcoma Virus (RSV), must associate with the inner leaflet of plasma membranes. O | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $184,564 | Grant | Trans-NIH Recovery Act Research Support: In recent years, there has been a growing appreciation for the complex roles that small regulatory RNA (sRNA) can play in coordinating gene activities in both prokaryotes and eukaryotes. There exists by now a basic understanding of the molecular componen | Health and Human Services, Department of / National Institutes of Health | 9/08/2009 |
| UNIVERSITY OF WASHINGTON | $228,414 | Grant | Trans-NIH Recovery Act Research Support: RNA editing in kinetoplastids, several of which are global pathogens, is a unique, and essential, process in the mitochondria of these ancient eukaryotes. This process uses hundreds of so-called 'guide RNAs' to edit an incomplete 'pre-messenger RNA' by U- | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| DREXEL UNIVERSITY | $280,059 | Grant | Trans-NIH Recovery Act Research Support: Genomic instability is a major cause of various genetic diseases. To understand how cells preserve genomic integrity, our investigation focuses on the role of replication fork proteins in genome maintenance mechanisms. Genomic instability is often associa | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| BRIGHAM YOUNG UNIVERSITY | $196,875 | Grant | Trans-NIH Recovery Act Research Support: Bacteria possess a remarkable system for translational quality control. In a process known as trans-translation, tmRNA enters stalled ribosomes and acts as a template, encoding a short peptide tag that marks the nascent polypeptide for destruction. The tm | Health and Human Services, Department of / National Institutes of Health | 7/30/2009 |
| UNIVERSITY OF PITTSBURGH THE | $227,250 | Grant | Trans-NIH Recovery Act Research Support: The parent grant, GM077872, focused on three major issues dealing with various aspects of the study of helicases and translocation activities of PcrA helicase using single molecule approaches. Helicases are ubiquitous enzymes present in all living cells t | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER | $160,731 | Grant | Trans-NIH Recovery Act Research Support: Cells lacking WHI5, the yeast equivalent of the pRB tumor suppressor gene, or SSF1, a ribosome biogenesis gene, deletions are small, hyper-proliferative, and long-lived. The objective of this supplement is to investigate the molecular mechanisms whereby | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE | $197,531 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of the project is to track the movement of the molecular motor myosin V within living cells as they walk on actin tracks. The properties of the motor or the properties of the track are perturbed, and the effect on motion is observed. Dr. | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $136,435 | Grant | Trans-NIH Recovery Act Research Support: Relevance: Anesthetics are dangerous and may cause learning disabilities in children. This research defines the sites/processes by which anesthetics act, necessary for developing safer anesthetics. This administrative supplement is consistent with the ARR | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| UNIVERSITY OF CHICAGO, THE | $299,747 | Grant | Trans-NIH Recovery Act Research Support: Drosophila embryogenesis is characterized by a highly orchestrated set of events directed by a regulatory gene cascade that creates a coordinate system along the anterior-posterior and dorsal-ventral axes of the embryo. This process must be highly canaliz | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $144,375 | Grant | Trans-NIH Recovery Act Research Support: We propose to take advantage of our novel finding, that CM from competing cell populations contains factors that activate either a winner or a loser genetic program in na+?ve cells, to uncover the signaling sensors and mediators of the cell competition pr | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| NEW YORK UNIVERSITY (INC) | $309,778 | Grant | Trans-NIH Recovery Act Research Support: Our long-term goal is to understand how apoptosis and cell proliferation are coordinated during animal development. Proliferating cells readily undergo injury-provoked apoptosis, while postmitotic cells acquire resistance to many apoptotic stimuli. Resist | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF PITTSBURGH THE | $138,683 | Grant | Trans-NIH Recovery Act Research Support: One of the central presumptions in molecular biology is that RNA functions mainly as an informational intermediate between the DNA sequence of a gene and the protein encoded by it. Although the principle is generally true in basal organisms, human cells c | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $233,612 | Grant | Trans-NIH Recovery Act Research Support: There are resident populations of T cells in human epidermis and dermis, but the role of these T cells in wound healing has not been examined. We will determine the mechanisms of skin T cell function in wound healing and if these functions are unique to s | Health and Human Services, Department of / National Institutes of Health | 7/31/2009 |
| THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK INC | $223,028 | Grant | Trans-NIH Recovery Act Research Support: This is an application for administrative supplement to my currently active RO1 grant ?Epigenetic regulation by PWWP domain proteins?. Our research is focused on understanding the role of epigenetic mechanisms, especially posttranslational modification of | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $285,097 | Grant | Trans-NIH Recovery Act Research Support: This supplement application is intended to enhance and extend the parent grant that is directed toward an assessment of the biological effects of manufactured carbonaceous nanoparticle exposure on barrier cell epithelia, materials that would be found in a | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $278,653 | Grant | Trans-NIH Recovery Act Research Support: ?Molecular genetics of thermotaxis and insect response to insect repellents? The focus of the parent grant is to dissect the mechanisms underlying thermotaxis and the aversion to insect repellents in the fruit fly. The specific goals are to identify and c | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| NORTHWESTERN UNIVERSITY | $236,779 | Grant | Trans-NIH Recovery Act Research Support: For the past several decades, NIH and NIGMS have led efforts to increase diversity among biomedical scientists. Despite committing great financial and human resources to this goal, relatively little progress has been made, especially among science faculty | Health and Human Services, Department of / National Institutes of Health | 8/07/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $99,233 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This proposal aims to improve and exploit fluorescent proteins (FPs); quantum dots (QDs), methods for delivery of nanoparticles such as QDs to cytoplasmic targets, and techniques for correlative optical/electron micros | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF MASSACHUSETTS | $802,320 | Grant | Trans-NIH Recovery Act Research Support: Abstract: Paradigm shifting studies in the monarch butterfly (Danaus plexippus) have enhanced our view of the evolution and function of circadian clocks in animals. The Specific Aims of Parent Grant expand our knowledge of the unique properties of the CR | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $169,500 | Grant | Trans-NIH Recovery Act Research Support: The overall goals of our research are to develop new therapies for acid sphingomyelinase (ASM)-deficient Niemann-Pick disease (Types A & B NPD), & to better understand the pathogenesis of this disorder. To date, this research has led to the isolation & ch | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| DUKE UNIVERSITY | $10,383 | Grant | Trans-NIH Recovery Act Research Support: In this supplement, we propose to further characterize the programs in the ovary which antagonize the male pathway and ask the question, what role do XX germ cells play in blocking testis cord formation. Several lines of evidence suggest that XX germ ce | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $76,755 | Grant | Trans-NIH Recovery Act Research Support: This proposal is for a Recovery Act administrative supplement. It is proposed to appoint a new postdoctoral fellow and thereby stimulate the economy by enabling the hiring of additional staff. The supplement also will accelerate the progress and expand th | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $74,832 | Grant | Trans-NIH Recovery Act Research Support: Vulvodynia is a chronic pain disorder, consisting of vulvar pain (burning, stabbing, irritation) for three months or longer, and lack of an infectious or dermatologic diagnosis consistent with the pain. The clinical characteristics of vulvodynia, and resp | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $163,301 | Grant | Trans-NIH Recovery Act Research Support: Overall Purpose and expected outcome. Funds provided by the Recovery Act will allow us to complete work begun during the past five years in order to advance clinical research on the effects and effectiveness of pharmaceuticals in child health. The funds | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $13,068 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Leiomyomata (fibroids) are a non-malignant neoplasia of uterine smooth muscle cells (UtSMC) that afflict approximately 20% of all women and 80% of black women in the U.S. The most common tumor in women, fibroids cause | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK INC | $35,305 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement provides support to accelerate the tempo of our research on how work-family policies affect mothers? and fathers? decisions about work in the labor market and care arrangements for their children, and how those decisions in | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| THE VANDERBILT UNIVERSITY | $59,404 | Grant | Trans-NIH Recovery Act Research Support: Gdf6 is a member of the BMP (Bone Morphogenetic Protein) gene family of secreted signaling ligands. Gdf6 is required for patterning and development of various skeletal and nonskeletal structures, including limb, ear and spine joints, and digits, skull sut | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| GEORGETOWN UNIVERSITY (THE) | $215,027 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement (3R01 HD049347-09S1 - RX4222416) will be used to purchase and set up an MR (Magnetic Resonance)-compatible electroencephalography (EEG) system for performing concurrent Event-Related Potential (ERP) / functional Magnetic Res | Health and Human Services, Department of / National Institutes of Health | 6/24/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $54,410 | Grant | Trans-NIH Recovery Act Research Support: We propose the rapid decline of CBP and associated histone acetyltransferase (HAT) activity during maturation serves the function of ending a series of critical periods of organization, especially in the brain, but by reducing transcriptional flexibility | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | $184,737 | Grant | Trans-NIH Recovery Act Research Support: The NHGRI recently approved the sequencing of eight additional species of Drosophila to assist in comparative annotation of the D. melanogaster genome as part of the modENCODE project (1). As a careful annotation of these genomes is essential to their eff | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| POLYTECHNIC INSTITUTE OF NEW YORK UNIVERSITY | $99,632 | Grant | Trans-NIH Recovery Act Research Support: This American Recovery and Reinvestment Act (ARRA) supplement seeks to establish an instrumentation facility to accelerate development of morpholino (MO) microarray technology pursued under the parent award. The proposed instrument will document history o | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF FLORIDA | $16,994 | Grant | Trans-NIH Recovery Act Research Support: This grant provided summer research experiences for 2 college students in health-related scientific research | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $67,043 | Grant | Trans-NIH Recovery Act Research Support: Title of project is ?Chloride channels in Lung Development?. Cystic Fibrosis is an orphan disease affecting 30,000 people in USA. The gene that causes CF is the CFTR, a cAMP-regulated chloride channel. The disease is fatal with no cure. This grant is deve | Health and Human Services, Department of / National Institutes of Health | 6/11/2009 |
| UNIVERSITY OF ILLINOIS | $19,468 | Grant | Trans-NIH Recovery Act Research Support: This award is a supplement to the parent grant, HL68819. This supplement has enabled the hiring of an undergraduate student to assist in accelerating the research aims of this parent grant, while promoting the education and research skills of students int | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| BAYLOR COLLEGE OF MEDICINE | $48,046 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this study is to understand retinoid-dependent cardiovascular development and analyze ventricular proliferation in Raldh2 mutants. | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $187,911 | Grant | Trans-NIH Recovery Act Research Support: Anemia, characterized by a deficiency of red blood cells, is a common condition that is treated with either blood transfusions or the hormone erythropoietin (Epo). We have found that a treatment for cancer, the inhibition of the hormone Vascular Endothel | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $214,694 | Grant | Trans-NIH Recovery Act Research Support: Inflammation is implicated in the pathogenesis of many diseases. In the lung, some of the examples include asthma, bronchitis, sarcoidosis, and a variety of disorders that ultimately lead to the loss of lung function. Monocytes are important components du | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF ROCHESTER | $199,861 | Grant | Trans-NIH Recovery Act Research Support: This grant supplement will support studies of a new therapeutic for pulmonary fibrosis (scarring). Studies will examine the role of small molecule ligands for the peroxisome proliferator activated receptor gamma (PPARg) in preventing and inhibititing prog | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF IOWA, THE | $182,679 | Grant | Trans-NIH Recovery Act Research Support: Approximately 6 million people in the United States suffer from chronic angina, a painful sensation resulting from myocardial ischemia in the setting of coronary artery disease. Ischemia is sensed by sensory (afferent) neurons, and activation of these car | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $223,549 | Grant | Trans-NIH Recovery Act Research Support: The project allows the team to focus in depth on the analysis and computer automation aspects of the research project. Briefly, the R01 project includes complex MRI experiments designed to obtain images and physiological data in lean, middleweight and obe | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $171,006 | Grant | Trans-NIH Recovery Act Research Support: CFTR Delivery to Ciliated Airway Cells by PIV Vectors-ARRA Our goal is to develop a gene therapy for cystic fibrosis (CF) lung disease. Patients with CF lack a correct copy of a single gene called CFTR. CFTR is normally expressed the ciliated epithelial | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE | $191,246 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this work was to elucidate the cellular mechanisms contributing to Ca2+ entry and constriction of cerebral arteries in health and disease.-? Subarachnoid hemorrhage (SAH) following cerebral aneurysm rupture is associated with substanti | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $147,263 | Grant | Trans-NIH Recovery Act Research Support: In mammalian heart, a comprehensive array of voltage-gated potassium (Kv) channels serve to drive myocyte repolarization by opening in response to depolarization to allow K+ ions to leave the myocyte and restore a negative resting potential. Disturbances | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $261,650 | Grant | Trans-NIH Recovery Act Research Support: 1 strategy for identifying novel atherosclerosis-related genes and pathways is through a combination of studies using mouse models and human populations. Using this approach, we recently identified 5-lipoxygenase (5-LO), the rate-limiting enzyme in leukot | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $292,160 | Grant | Trans-NIH Recovery Act Research Support: Cancers that are resistant to standard chemotherapy and radiation may be treatable using components of the immune system. We propose to use immune cells, T cells, that recognize targets on tumor cells as a means of treating patients with advanced (metasta | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| BAYLOR COLLEGE OF MEDICINE | $256,481 | Grant | Trans-NIH Recovery Act Research Support: The additional aim will test if litter gender composition affects DNA methylation patterns in promoter regions of targeted genes in brain regions associated with stress responses (hippocampus) and drug reward (NAc; PFC) across the life span. Our hypothes | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $18,360 | Grant | Trans-NIH Recovery Act Research Support: To investigate the mechanism of odorant receptor (OR) selection and maintenance, in the parent application we proposed to define OR sequence fragments that are responsible for OR transcription suppression. This research proposal aims to accelerate and exp | Health and Human Services, Department of / National Institutes of Health | 7/10/2009 |
| UNIVERSITY OF ILLINOIS | $13,502 | Grant | Trans-NIH Recovery Act Research Support: Administrative Supplements Providing Summer Research Experiences This application funded two undergraduate research students for the summer to work on my NIH funded R21 grant. It also provided additional funds for research supplies. | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| UNIVERSITY OF MEDICINE AND DENTISTRY OF NJ (INC) | $16,598 | Grant | Trans-NIH Recovery Act Research Support: The parent grant application focuses on the induction of the expression and activity of an antimicrobial peptide gene, hCAP-18 or LL-37, in gingival epithelial cell (GEC) cultures in response to Vitamin D. A more complete characterization of this inducti | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $99,987 | Grant | Trans-NIH Recovery Act Research Support: Major aims of our original award involve defining how chromatin structure varies during erythroid differentiation. We have compared profiles from H1 hES cells, CD34 cells and their differentiated progeny and compared them to T-lymphocytes. In addition, to | Health and Human Services, Department of / National Institutes of Health | 11/25/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $100,000 | Grant | Trans-NIH Recovery Act Research Support: Obesity has reached epidemic levels in the U.S., with 66% of adults overweight and 32% of adults obese. The research uses the new technique of three-dimensional (3 D) photonic scanning to create and validate an instrument that rapidly assesses obesity in | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| WAKE FOREST UNIVERSITY | $100,640 | Grant | Trans-NIH Recovery Act Research Support: This application targets the millions of patients suffering from bladder disease/dysfunction related to congenital anomalies, cancer, infection, inflammation or lesions of the central or peripheral nervous system. Regardless of etiology, in all cases thes | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $131,445 | Grant | Trans-NIH Recovery Act Research Support: The parent grant will examine the impact of traffic-related air pollution exposure on perinatal outcomes (e.g. preterm birth, low birth weight, intrauterine growth restriction). The supplement award will further improve exposure assessment of pregnant wo | Health and Human Services, Department of / National Institutes of Health | 9/02/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $75,000 | Grant | Trans-NIH Recovery Act Research Support: As defined in the Award Description Field We continue to work on all aspects of the project. We have made several observations with two of the new genes we identified that provide important insight into their function. First, we have interesting evidenc | Health and Human Services, Department of / National Institutes of Health | 9/02/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $333,278 | Grant | Trans-NIH Recovery Act Research Support: Kv1 family voltage-dependent potassium channels are highly expressed in heart and important for repolarization of a cardiac action potential. In humans, loss-of-function mutations of Kv1 channels are directly linked to atrial fibrillation. Kv1 channels ar | Health and Human Services, Department of / National Institutes of Health | 7/31/2009 |
| THE INSTITUTE FOR CANCER RESEARCH | $94,700 | Grant | Trans-NIH Recovery Act Research Support: Title: Structure and Dynamic Determinants of Ion Channel Assembly by Adapter Proteins (Administrative Supplement) Abstract: The devastating disease cystic fibrosis is caused by the inability of the cell to bring the cystic fibrosis transmembrane conduct | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $289,170 | Grant | Trans-NIH Recovery Act Research Support: Asthma affects over 17 million people in the United States. Nearly one-half of patients do not respond to treatment with the most effective classes of currently available asthma therapeutics. In order to develop novel therapies, a comprehensive catalog of | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $333,282 | Grant | Trans-NIH Recovery Act Research Support: Pathological vascular remodeling is a key component and frequently life-threatening consequence, of vascular diseases in both the systemic and pulmonary circulation. In a neonatal model of hypoxic pulmonary hypertension, we have demonstrated that hypoxia- | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| LA JOLLA BIOENGINEERING INSTITUTE | $340,200 | Grant | Trans-NIH Recovery Act Research Support: During the parent grant-related activities, we showed that administration of the calcium channel blocker nimodipine in combination with the antimalarial drug artemether to mice with cerebral malaria (CM) doubles the survival rates. This revision will addr | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| NEVADA CANCER INSTITUTE | $100,800 | Grant | Trans-NIH Recovery Act Research Support: The proposed studies are based on our innovative and productive nature of the ongoing work (see our recent publications) and the value to this work that the new employee, a postdoc is being brought in. Our hypothesis, which is supported by our unique mode | Health and Human Services, Department of / National Institutes of Health | 12/07/2009 |
| UNIVERISTY OF MISSISSIPPI MEDICAL CENTER | $264,624 | Grant | Trans-NIH Recovery Act Research Support: The supplement supports the parent grant titled Regulation of IL-6 Type Cytokine Cardioprotective Signaling in the Ischemic Heart and is being used to employ postdoctoral fellow, Dr. Thomas Sebastian, a trained molecular biologist, who has relocated to Ja | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| UNIVERSITY OF KENTUCKY | $258,056 | Grant | Trans-NIH Recovery Act Research Support: iPLA2 (calcium independent phospholipase A2) is a member of the phospholipase A2 superfamily that is expressed in vascular smooth muscle and exhibits diverse cellular functions. Our preliminary data show that iPLA2 is activated/up-regulated in the vascula | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| CEDARS-SINAI MEDICAL CENTER | $406,250 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Sudden cardiac death (SCD) remains a major cause of mortality in the US. While the prophylactic implantable defibrillator has significantly reduced the incidence of SCD under the current eligibility criterion of severe | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF UTAH, THE | $134,893 | Grant | Trans-NIH Recovery Act Research Support: Principal Investigator/Program Director (Last, first, middle): Zaitsev, Alexey, V. RESEARCH & RELATED Other Project Information 1. * Are Human Subjects Involved? m Yes l No 1.a. If YES to Human Subjects Is the IRB review Pending? m Yes m No IRB Approval D | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $274,944 | Grant | Trans-NIH Recovery Act Research Support: The goal of these studies is to determine the pathway(s) by which hepatocytes ingest platelets to acceler- ate their clearance from the circulation. Until recently, the only well-established mechanisms affecting platelet survival were antibody-mediated pl | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| WASHINGTON UNIVERSITY, THE | $221,922 | Grant | Trans-NIH Recovery Act Research Support: Breathing is generated by neurons in the brainstem. One limitation of our current understanding of the neural circuits underlying breathing is the lack of genetic markers for the unambiguous identification of specific neural populations. We hypothesize | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF PITTSBURGH THE | $197,530 | Grant | Trans-NIH Recovery Act Research Support: Award Description (one-time requirement unless there is a shift in goals from initial intent): Coronary heart disease is the leading cause of premature disability and death in the United States and other industrialized nations. The progression of heart d | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | $37,178 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is a complex arrhythmia that afflicts more than 2.3 million Americans. Most prevalent in the elderly, AF is associated with a 2-fold higher risk for mortality. AF is the most potent risk factor | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| NATIONAL JEWISH HEALTH | $283,204 | Grant | Trans-NIH Recovery Act Research Support: The Acute Respiratory Distress Syndrome (ARDS) is a severe response to a broad range of infectious insults. We believe that the occurrence and severity of ARDS can be mediated by an impairment of the capacity of neutrophils to effectively respond to bacte | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $42,413 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement is concerned with the optimization and reduction to practice of an assay for a biomarker, PGP, that appears diagnostic and perhaps prognostic for COPD. Although it is currently possible to measure elevated PGP levels in COP | Health and Human Services, Department of / National Institutes of Health | 5/30/2009 |
| CLEMSON UNIVERSITY | $34,413 | Grant | Trans-NIH Recovery Act Research Support: Project Narrative Abdominal aortic aneurysms (AAAs) are potentially fatal conditions afflicting major blood vessels, which are characterized by a loss of blood vessel wall flexibility, and their ultimate structural weakening and rupture. This occurs due t | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| RAND CORPORATION. THE | $29,907 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): There have been many efforts to assess the intensity, frequency and duration of PA among males and females and people of all ages, but few efforts to objectively assess population level measures of PA. Determining popu | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| NATIONAL JEWISH HEALTH | $203,666 | Grant | Trans-NIH Recovery Act Research Support: During lung development FGF10 (Fibroblast growth factor 10) is secreted by the parabronchial smooth muscle cell (PSMC) progenitors in the distal mesenchyme and activates the canonical WNT signaling pathway in the distally located epithelial progenitors to | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF SOUTH ALABAMA | $144,981 | Grant | Trans-NIH Recovery Act Research Support: THE PURPOSE OF THIS SUPPLEMENT REQUEST IS TO HIRE NEW KEY PERSONNEL AND PURCHASE NEW EQUIPMENT. SPECIFICALLY, TO HIRE A POST-DOCTORAL FELLOW TO CONDUCT IN VIVO MEASUREMENTS OF OXIDATIVE STRESS. THIS WILL: 1) REDUCE ANIMAL NUMBERS NEEDED, AND 2) INCREASE T | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $313,912 | Grant | Trans-NIH Recovery Act Research Support: Cardiac hypertrophic remodeling underlies a large component of the morbidity and mortality of heart disease. It affects nearly 10% of the world?s population given the high prevalence of hypertension and hypertrophy that evolves with it. Cyclic guanosine-3 | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| NORTHWESTERN UNIVERSITY | $239,796 | Grant | Trans-NIH Recovery Act Research Support: The Administrative supplement request is for the hiring of a new full time employee (along with supplies and equipment) to increase the tempo and output of the parent project. | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $203,038 | Grant | Trans-NIH Recovery Act Research Support: About 1% of newborn babies in the US have congenital heart disease (CHD), the leading cause of death among infants. Hemodynamic forces, which are wall shear stresses and pressures generated by the flow of blood, are key factors that regulate heart develop | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| THE JACKSON LABORATORY | $258,122 | Grant | Trans-NIH Recovery Act Research Support: Elevated levels of plasma high-density lipoprotein cholesterol (HDL) protect against cardiovascular disease, which is the leading cause of death in the United States. Identifying the genes involved in the regulation of HDL may reveal some novel genes and | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $252,535 | Grant | Trans-NIH Recovery Act Research Support: Myeloproliferative disorders (MPDs) are clonal hematologic malignancies characterized by overproduction of one or more myeloid lineage cells. Chromosomal translocations or mutations in protein tyrosine kinases are frequently observed in MPDs. For example, | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $293,934 | Grant | Trans-NIH Recovery Act Research Support: The overall purpose of these studies is to identify patient-specific factors related to the balance between the recipient cells and donor cells in patients who received a hematopoietic stem cell transplant. We will look at two types of patient-specific f | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| UNIVERSITY OF LOUISVILLE | $102,370 | Grant | Trans-NIH Recovery Act Research Support: This project pursues the hypothesis that interactive computer graphics will be a revolutionary technology for instruction in biological and medical science. The core method has been to develop canonical systems for computer-based learning in neuroanatomy | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| METHODIST HOSPITAL RESEARCH INSTITUTE, THE | $144,638 | Grant | Trans-NIH Recovery Act Research Support: We propose to develop an integrated computational system to track and analyze neuronal dendrites and spines observed in 3D time-lapse optical microscopy and manage all the data. The proposed work will overcome one barrier in neuroscience research, i.e.,la | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| UNIVERSITY OF PITTSBURGH THE | $130,902 | Grant | Trans-NIH Recovery Act Research Support: Current syndromic surveillance from clinical data is limited to monitoring chief complaints, which are only moderately sensitive to detecting syndromic cases. In our parent proposal, we are applying both foundational and applied research to improve our ab | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| UNIVERSITY OF WASHINGTON | $219,547 | Grant | Trans-NIH Recovery Act Research Support: This supplement will conduct secondary analyses of an existing data set that addresses three specific aims delineated in the parent grant Multisite Prevention of Adolescent Conduct Problems. The parent grant focused on a) the evaluation of a developmental | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $100,000 | Grant | Trans-NIH Recovery Act Research Support: The proposed multisite research project seeks to advance our understanding of the neural mechanisms underlying human spatial memory. Epileptic patients undergoing surgical invasive monitoring as part of the clinical treatment of drug resistant epilepsy wi | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $478,858 | Grant | Trans-NIH Recovery Act Research Support: The parent grant of this supplement application is focused on testing the mechanistic hypothesis that oligodendrocyte and myelin related (OMR) gene and protein expression deficits in schizophrenia (SZ) are due, at least in part, to abnormalities in the ex | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF CINCINNATI | $104,270 | Grant | Trans-NIH Recovery Act Research Support: Dysfunction of the hypothalamo-pituitary-adrenocortical (HPA) axis is a common feature of major affective illnesses. Neuroendocrine disturbances are typically manifest as cortisol hypersecretion and glucocorticoid negative feedback resistance, both of whi | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF PITTSBURGH THE | $331,753 | Grant | Trans-NIH Recovery Act Research Support: Older adults with a history of depression seem to be at increased risk of developing progressive dementia. The reasons for this increased risk are not well understood. This supplemental study to an ongoing research grant (R01 MH072947) will gather informa | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF ILLINOIS | $454,047 | Grant | Trans-NIH Recovery Act Research Support: The following two aims are designed to supplement our ongoing investigation into the role of tomosyn, which we have shown negatively regulates synaptic transmission at C. elegans synapses. Aim 1) Generate and characterize Drosophila tomosyn mutants. To | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $312,976 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Neurexins play an important role at the synapse, promoting adhesion and communication between neurons. More than 2000 neurexin isoforms are generated through a process called alternative splicing. WORKING MODEL: Neurex | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $175,927 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this administrative supplement is to stimulate basic and translational research into the neurobiological substrates of social behavior, thus providing greater insight into the mechanisms of psychiatric disorders with known deficits in socia | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| SEATTLE CHILDREN'S HOSPITAL | $534,444 | Grant | Trans-NIH Recovery Act Research Support: Intermediate Progenitor Cells in Adult Hippocampal Neurogenesis -- This project revision extends our analysis of hippocampal neurogenesis from adulthood, the focus of the parent grant, into postnatal ages in mice. The overall goal of the parent project | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| HARTFORD HOSPITAL | $326,789 | Grant | Trans-NIH Recovery Act Research Support: Adolescence is a distinct developmental period during which ?executive? control over behavior and cognition improves towards mature, adult levels of performance on neuropsychological tests. It has been proposed that these cognitive gains are the product o | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| DANA-FARBER CANCER INSTITUTE, INC. | $34,761 | Grant | Trans-NIH Recovery Act Research Support: The ultimate goal of this program of research is to maximize positive health outcomes for those with cancer by creating opportunities in a supportive environment for individuals to fully express themselves regarding cancer symptoms and quality of life con | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON | $67,060 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this multi-site, randomized, controlled trial is to determine the optimal frequency of repositioning nursing facility residents with mobility limitations who are at moderate and high risk for pressureulcer development who are cared for on h | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| UNIVERSITY OF WASHINGTON | $172,561 | Grant | Trans-NIH Recovery Act Research Support: This administrative supplement concerns physiological modulation of ion channels through G-protein-coupled receptors and seeks mechanistic and quantitative understanding of the signaling steps at the molecular level. The signals studied are generated by M | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| FLORIDA STATE UNIVERSITY, THE | $111,891 | Grant | Trans-NIH Recovery Act Research Support: OVERALL GOAL: The overall goal is to advance understanding of neural mechanisms of endometriosis, a common and distressing disorder defined by extrauteral growths of endometrial tissue. Symptoms include severe chronic pains, such as dyspareunia (vaginal h | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| NEW YORK MEDICAL COLLEGE | $68,850 | Grant | Trans-NIH Recovery Act Research Support: Evidence from our ongoing behavioral studies in narcoleptic, orexin receptor deficient mice indicate that increases in cholinergic outflow following the loss of orexin signaling contributes to the disregulation of muscle atonia (cataplexy) which occurs in | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $51,381 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this project is to understand how the properties of neurons are modulated by changes in oxygen concentration and cyclic GMP (cGMP). The intracellular messenger, cyclic GMP (cGMP), is a mediator of many physiological processes includi | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| ALLEGHENY-SINGER RESEARCH INSTITUTE | $15,392 | Grant | Trans-NIH Recovery Act Research Support: Multimodal CT and MRI are available to study and diagnose stroke pathological progression, can rule out hemorrhagic stroke, and possibly can be used to extend the time limit for thrombolysis, but there is no way to determine the time limit after which rep | Health and Human Services, Department of / National Institutes of Health | 7/24/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $14,644 | Grant | Trans-NIH Recovery Act Research Support: This grant is exploring the role of intracellular Ca2+ in the migration/invasion of normal and malignant glial cells. Specifically we are examining the role of Ca2+-activated K+ channels (KCa), a super-family of ion channels that have the unique ability t | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $111,670 | Grant | Trans-NIH Recovery Act Research Support: Neonatal seizures associated with hypoxic encephalopathy are refractory to conventional AED therapy, and are associated with long term neurodevelopmental delay, cognitive impairment and epilepsy. The newborn brain is fundamentally different from the adult | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| NEW YORK UNIVERSITY (INC) | $121,012 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this award is to accelerate specific aims 1 and 3 in the parent R01. These aims pertain to the elucidation of an apparent electrogenic acid-base transporter in hippocampal neurons that is responsible for the increase in cytosolic pH upon de | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $125,001 | Grant | Trans-NIH Recovery Act Research Support: A prevalent neuromodulatory mechanism involves G protein-coupled receptors that link via Gqjll a subunits (GaqPCRs) to inhibit background K+ channels, evoking depolarization and increased neuronal excitability. Our work has focused on GaqPCR modulation of | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| NORTHWESTERN UNIVERSITY | $38,940 | Grant | Trans-NIH Recovery Act Research Support: This supplement will be used for equipment and Animal purchase and cost to speed up the tempo of the research. | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $271,872 | Grant | Trans-NIH Recovery Act Research Support: Our supplement Aim is to determine the role of neural synchrony in learning and implementing rules by recording neural activity with a denser electrode array. One of the vexing questions of systems neuroscience is how multiple types of information (e.g., | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $282,858 | Grant | Trans-NIH Recovery Act Research Support: We will hire and/or retain analysts and a data manager who will focus on the PD GWAS Consortium dataset and allow us to more rapidly combine the data from the 6 studies. By increasing the rate of analysis at this stage, we can proceed to the replication | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF CHICAGO, THE | $117,000 | Grant | Trans-NIH Recovery Act Research Support: DA and other members of the TO subgroup of Theiler's murine encephalomyelitis virus (TMEV) group induce a persistent infection, with a restricted virus gene expression, associated with chronic inflammatory demyelination of the spinal cord. Evidence sugges | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| WASHINGTON UNIVERSITY, THE | $32,258 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of this proposal is to define molecular mechanisms that control synaptic strength. Synapses are dynamic-once formed, neural circuits evolve by the addition and elimination of synaptic connections and the modification of their strength. | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| NEW YORK UNIVERSITY (INC) | $508,847 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This is a Competitive Revision Application to grant 2 R01 NS045217-06 titled Molecular components of A-type K+ channels in response to Notice Number (NOT-OD-09-058) titled :NIH Announces the Availability of Recovery A | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF VERMONT & STATE AGRICULTURAL COLLEGE | $220,499 | Grant | Trans-NIH Recovery Act Research Support: This supplement was to fund an additional postdoctoral research fellow in order to expedite the progress on the parent award. The expected outcome was the appropriation of data and results for publication related to the aims of the parent award. | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $53,550 | Grant | Trans-NIH Recovery Act Research Support: A major goal of neuroscience is to understand the dynamics of neural circuits. In most circuits, ignorance of intrinsic neural properties and synaptic organization limits our ability to understand the circuit?s function or to cure disorders of the nervou | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF FLORIDA | $21,383 | Grant | Trans-NIH Recovery Act Research Support: See comment.This project uses recombinant adeno-associated viral vectors to deliver genes encoding constructs to knock-down huntingtin in striatal neurons. Long-term knock-down of striatal huntingtin will test the hypothesis that reduced huntingtin expres | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $39,457 | Grant | Trans-NIH Recovery Act Research Support: Two undergraduate students will be recruited to perform experiments consistent with the specific aims of the parent R01 grant. One student will study the developmental time course of KCNQ and sodium channel arrival at the axon initial segment. One stude | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $107,302 | Grant | Trans-NIH Recovery Act Research Support: In Aim 1 of this supplement, we will test the requirement for N-WASP activation of Arp2/3 during EphrinB-induced spine maturation. In Aim 2 of this supplement will characterize the in vivo requirement for AFAP in neuronal differentiation. | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $596,418 | Grant | Trans-NIH Recovery Act Research Support: Eleven total Yucatan Minipigs have been ordered and received. All animals underwent a course of oral antibiotics for bone-labeling. Following antibiotics, a bone biopsy procedure was performed taking core bone samples from the fourth cervical vertebral b | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $17,584 | Grant | Trans-NIH Recovery Act Research Support: Our laboratory provides an excellent environment for undergraduates and high school educators/students to gain research experiences and to subsequently pursue an academic career in biomedical research. The administrative supplement will not only provide | Health and Human Services, Department of / National Institutes of Health | 7/29/2009 |
| UNIVERSITY OF MIAMI | $100,980 | Grant | Trans-NIH Recovery Act Research Support: Pain from injury to the peripheral or central nervous system is often persistent and debilitating, and presents a significant clinical challenge as it does not respond well to traditional therapies. The underlying hypothesis and motivation for these stud | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $203,976 | Grant | Trans-NIH Recovery Act Research Support: Pathological cell death occurs in the course of Huntington'sdisease (HD), Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis (ALS) and also after acute brain trauma and cerebral ischemia. Drugs that inhibit caspases (enzymes that | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF NEW MEXICO | $139,204 | Grant | Trans-NIH Recovery Act Research Support: Vascular cognitive impairment (VCI) is a heterogeneous disorder that is a major cause of dementia. Selection of patients with small vessel disease, subcortical ischemic vascular dementia (SIVD), provides a more homogenous population that would facilitate | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| EMORY UNIVERSITY | $297,600 | Grant | Trans-NIH Recovery Act Research Support: Title: CART Regulation of Wakefulness DESCRIPTION (provided by applicant): CART (Cocaine and Amphetamine-Regulated Transcript) peptides appear to mediate behaviors associated with psychostimulant drugs including: hypothalamically mediated suppression of f | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| BROWN UNIVERSITY IN PROVIDENCE IN STATE OF RI AND PROVIDENCE PLANTATIONS | $120,393 | Grant | Trans-NIH Recovery Act Research Support: In this proposal we study the physiological significance of cell-specific alternative splicing of the voltage-gated N-type calcium channel CaVa1 subunit in nociceptive neurons of the dorsal root ganglia. N- type calcium channels regulate release of gluta | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $237,300 | Grant | Trans-NIH Recovery Act Research Support: We have investigated potential links between astrocyte reactivity and lesion repair using microarray analysis of cytokine-treated human astrocytes, and this approach has identified interleukin-11 (IL-11) as an astrocyte- derived factor that regulates olig | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| NORTHWESTERN UNIVERSITY | $174,688 | Grant | Trans-NIH Recovery Act Research Support: This supplement will be used to fund the continuation of our current senior post-doctoral fellow. Also it will bed used to purchase important equipment for the proposed experiments. | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $22,096 | Grant | Trans-NIH Recovery Act Research Support: This award is intended to provide a summer research experience for an undergraduate student with an interest in pursuing a career in neuroscience and to accelerated tempo of work on parent grant. The central hypothesis of the parent grant is that GABA(A) | Health and Human Services, Department of / National Institutes of Health | 7/19/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $140,131 | Grant | Trans-NIH Recovery Act Research Support: In higher vertebrates, nerve conduction is greatly facilitated by myelin, a lipid-rich membrane that wraps around the axon. Myelin is formed by oligodendrocytes in the central nervous system (CNS) and by Schwann cells in the peripheral nervous system (PN | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $425,537 | Grant | Trans-NIH Recovery Act Research Support: ARRA Supplement funds are requested to amplify and accelerate the design, building and testing of the Large Size (3Kx4K pixels) Direct Detection Device (DDD) currently supported by the R01 RR018841 grant by the NCRR titled ?A Completely New Camera System | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO | $567,100 | Grant | Trans-NIH Recovery Act Research Support: UltraScan is a comprehensive software package for the analysis of hydrodynamic data from analytical ultracentrifugation and light scattering experiments. Data from such experiments provide insight into the dynamic interactions among macromolecules involve | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $135,714 | Grant | Trans-NIH Recovery Act Research Support: CD-HIT is a computer program for clustering and comparing large sets of protein or nucleotide sequences. It helps to significantly reduce the computational and manual efforts in various sequence analysis tasks and aids in understanding the data structure | Health and Human Services, Department of / National Institutes of Health | 8/25/2009 |
| UNIVERSITY OF OKLAHOMA | $60,000 | Grant | Trans-NIH Recovery Act Research Support: This NIH supplement is in conjunction with the parent grant efforts to better understand the role of wild birds in the spread of Highly Pathogenic Avian Influenza in Asia. Since late 2003 several East and Southeast Asia countries have experienced large ou | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| YALE UNIVERSITY | $69,909 | Grant | Trans-NIH Recovery Act Research Support: The general objective of this project is the functional and molecular characterization of the multiple members of the myosin (Myo) family of actin based molecular motors that are expressed in the intestinal epithelial cell (IEC). The supplement funds awar | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF KENTUCKY | $33,413 | Grant | Trans-NIH Recovery Act Research Support: As individuals age, muscle weakness and neuromuscular disorders have the potential to diminish the quality of life, increase health care costs, and lead to institutionalization. The larynx is part of a complex motor system that serves dually as the vibrat | Health and Human Services, Department of / National Institutes of Health | 5/20/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $52,833 | Grant | Trans-NIH Recovery Act Research Support: Streptococcus mutans is the primary cariogen that produces several virulence factors. The long-term goal of the proposed studies is to characterize specific interactions of S. mutans with oral bacteria in the dental plaque biofilm. We hypothesize that it | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| CAL POLY CORPORATION | $33,824 | Grant | Trans-NIH Recovery Act Research Support: Articular cartilage has a poor intrinsic healing capacity that is likely related to the relatively low cellularity, metabolic activity, and avascularity of AC. Current clinical repair strategies for treating cartilage defects include tissue grafting and t | Health and Human Services, Department of / National Institutes of Health | 6/16/2009 |
| MISSISSIPPI STATE UNIVERSITY | $67,200 | Grant | Trans-NIH Recovery Act Research Support: The rate-limiting step in reverse cholesterol transport from macrophages is the hydrolysis of cholesteryl esters to free cholesterol, which is subsequently transported out of the cell to cholesterol acceptors. In human macrophages, the enzyme responsible | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF THE SCIENCES IN PHILADELPHIA | $44,846 | Grant | Trans-NIH Recovery Act Research Support: In biological systems, transmembrane peptides embedded in lipid membranes are essential for cellular function such as ion conductance, energy conversion, and signaling. The goal of the parent grant is to gain a better understanding of the structural and d | Health and Human Services, Department of / National Institutes of Health | 7/10/2009 |
| REED INSTITUTE, THE | $98,503 | Grant | Trans-NIH Recovery Act Research Support: The project involves basic research designed to enhance our understanding of the genetics of RNA virus-host interactions. A number of pathogenic RNA viruses infect humans. Knowing more about virus-host interactions, particularly the rold of host gene prod | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| KENYON COLLEGE | $68,118 | Grant | Trans-NIH Recovery Act Research Support: pH Regulation in Bacillus subtilis | Health and Human Services, Department of / National Institutes of Health | 8/03/2009 |
| NEW MEXICO STATE UNIVERSITY | $189,247 | Grant | Trans-NIH Recovery Act Research Support: The relevance of this supplement to the parent grant is directly aligned to specific aim 3, which is to dtermine whether symbiotic genes are found in clusters based on whole genome comparisons. Efforts will be intensified by the addition of a postdoctora | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| RFCUNY - BROOKLYN COLLEGE | $194,178 | Grant | Trans-NIH Recovery Act Research Support: Individual investigator-initiated research projects aimed at developing researchers at minority-serving institutions (MSIs) to a stage where they can transition successfully to other s extramural support (R01 or equivalent). | Health and Human Services, Department of / National Institutes of Health | 7/31/2009 |
| RFCUNY - CITY COLLEGE | $157,889 | Grant | Trans-NIH Recovery Act Research Support: Research Enhancement Award: Individual investigator-initiated research projects aimed at developing researchers at minority-serving institutions (MSIs) to a stage where they can transition successfully to other extramural support (R01 or equivalent). | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY CORPORATION, THE | $80,250 | Grant | Trans-NIH Recovery Act Research Support: Apoptosis is a well-orchestrated pathway of physiological cell death, activated through alterations in the expression of growth regulatory/death-inducing genes. The long-term goal of this PI is to understand the molecular pathway for apoptosis, with empha | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| ALBANY STATE UNIVERSITY | $136,467 | Grant | Trans-NIH Recovery Act Research Support: The major aims of this supplement are to create a job for recent college graduates in chemistry or biology field through hiring an additional research staff, and to purchase a few Dell HPCC computer nodes and a KVM switch to enhance computational capacity | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| RFCUNY - HUNTER COLLEGE | $99,636 | Grant | Trans-NIH Recovery Act Research Support: Research Continuance Award: Individual investigator-initiated research projects for faculty at MSIs to conduct research of limited scope in environments with limited research infrastructure/facilities. | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $87,226 | Grant | Trans-NIH Recovery Act Research Support: The Stanford Biomedical Informatics (BMI) training program continues to offer MS and PhD degrees to students with an intensive training that prepares them for careers in research. The formal curriculum trains them in a five core areas: (1) core biomedica | Health and Human Services, Department of / National Institutes of Health | 7/23/2009 |
| WILLIAM MARSH RICE UNIVERSITY | $1,033,304 | Grant | Trans-NIH Recovery Act Research Support: For almost two decades, the W. M. Keck Center, which spans six biomedical institutions in the Greater Houston, Texas area, has trained pre- and postdoctoral fellows in biomedical informatics. Here we seek the renewal of one of our training programs (the N | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| SEATTLE BIOMEDICAL RESEARCH INSTITUTE | $25,600 | Grant | Trans-NIH Recovery Act Research Support: Funds from this administrative supplement will be used to obtain mass spectometry services and to purchase a flourescent dissection microscope. This is to support the parental NIH grant for work on proteomic analysis of the liver stage of the Plasmodium p | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| EPIVAX, INC. | $215,016 | Grant | Trans-NIH Recovery Act Research Support: The goal of this new R21 proposal is to develop a pro-inflammatory and non-tolerogenic HIV vaccine delivery system based on the dendritic cell targeting anti-DEC-205 antibody. The success of anti-DEC-205 as a stimulator of strong inflammatory immune respo | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |