Listing all stimulus spending by amount, in descending order. Return to National Institutes of Health page
Amount refers to both the amount of stimulus funding going toward the project and the face value of the loan.
| Recipient | Amount | Type | Description | Federal Dept./Agency | Date |
|---|---|---|---|---|---|
| WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY | $903,900 | Grant | Trans-NIH Recovery Act Research Support: Parkinson's disease (PD) is a devastating neurodegenerative disorder characterized by a loss of substantia nigra pars compacta neurons, which currently affects 1.5 million people in the United States. Although rare mutations associated with familial forms | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| KAISER FOUNDATION HOSPITALS | $402,527 | Grant | Trans-NIH Recovery Act Research Support: The proposed study will extend an innovative investigation of biologic markers for autism using archived prenatal and newborn specimens from mother-baby pairs. Funded by the NIMH (R01 MH72565) for an initial three-year period, this project, known as the E | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF HOUSTON SYSTEM | $495,802 | Grant | Trans-NIH Recovery Act Research Support: The perception of form is one of the most basic functions of the visual system. Because motion and dynamic occlusions are ubiquitous in our environment, understanding how the human visual system computes the form of moving objects in the presence of occl | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $573,255 | Grant | Trans-NIH Recovery Act Research Support: Vision provides us with information about the objects in the world around us; it also allows us to see the materials that they are made of. Material perception is important: for example, it lets people see whether a sidewalk is icy and it permits a physic | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| IOWA STATE UNIVERSITY OF SCIENCE AND TECHNOLOGY | $696,824 | Grant | Trans-NIH Recovery Act Research Support: In this proposal we will investigate the ability of neurotrophic growth factors delivered via genetically modified stem cell transplants into the eye to reduce the progression of damage and visual loss in an inducible rodent model of glaucoma (chronic ocu | Health and Human Services, Department of / National Institutes of Health | 6/03/2009 |
| NORTHWESTERN UNIVERSITY | $685,911 | Grant | Trans-NIH Recovery Act Research Support: Muller cells, the predominant glial cells in the vertebrate retina, play an essential role in maintaining neuronal health and activity. Recent work on retinal glia has also shown that virtually every retinal disease is associated with `activation' of Mull | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $222,000 | Grant | Trans-NIH Recovery Act Research Support: Role of the Tail Domain in Vinculin Function - ARRA SPECIFIC AIMS Vinculin is a cytoskeletal protein localized to cell-extracellular matrix as well as cell-cell contacts. In both locations, vinculin participates in the linkage of transmembrane receptors, | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $529,284 | Grant | Trans-NIH Recovery Act Research Support: A long-term goal of our lab is to understand the molecular basis of cell polarity and tissue morphogenesis in vertebrate embryos. Our focus here is on the Planar Cell Polarity (PCP) signaling cascade, a molecular mechanism that governs both the formation | Health and Human Services, Department of / National Institutes of Health | 6/19/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $496,622 | Grant | Trans-NIH Recovery Act Research Support: Imagine trying to engineer a biological sensor that senses a small drug molecule and responds by turning on the expression of a therapeutic protein, say insulin. Now imagine having a software tool that can assist in engineering the sensor quickly. The p | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $528,557 | Grant | Trans-NIH Recovery Act Research Support: Mechanisms of Mitotic Recombination ARRA Mitotic crossing over is detrimental because it can lead to loss of heterozygosity or chromosome rearrangement, both of which are associated with cancer. The dangers of mitotic crossing over are evident in persons | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| WASHINGTON UNIVERSITY, THE | $718,483 | Grant | Trans-NIH Recovery Act Research Support: Many individuals with Parkinson disease (PD) experience a reduction in mobility with gait difficulties thatinclude impaired turning that can trigger freezing. These turning difficulties are particularly critical since fallsduring turning carry an eightfol | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $2,185,009 | Grant | Trans-NIH Recovery Act Research Support: We are assessing the association between in utero exposure to specific antiretroviral therapy (ART) regimes and the risk of major congenital malformations and other clinical outcomes including fetal or neonatal death, preterm delivery, and fetal growth re | Health and Human Services, Department of / National Institutes of Health | 7/28/2009 |
| RHODE ISLAND HOSPITAL | $1,215,908 | Grant | Trans-NIH Recovery Act Research Support: This research evaluates the co-occurrence of asthma status (lung function and symptoms) and academic performance over the course of the school year in a group of urban, elementary (aged 7-9) school children from African-American, Hispanic, and Non-Hispani | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $1,118,590 | Grant | Trans-NIH Recovery Act Research Support: This project aims to construct a set of standard anatomical templates for pediatric neuroimage analysis. It is designed to leverage the NIH funded MRI Study of Normal Brain Development, specifically the DTI (Diffusion Tensor Imaging) ancillary study. The | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| WAKE FOREST UNIVERSITY | $666,000 | Grant | Trans-NIH Recovery Act Research Support: About 10 percent of American families are affected by infertility. Among which, one third of these cases are due to female factors, one third to male factors, and the remainder are a mixture or have unknown causes. Mitochondrial dysfunction is responsible | Health and Human Services, Department of / National Institutes of Health | 7/28/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $785,000 | Grant | Trans-NIH Recovery Act Research Support: The aim of this application is to investigate the role of these caspases in villous cytotrophoblast differentiation. The ultimate goal of this investigation is to identify the critical components controlling the mechanism of villous cytotrophoblast diffe | Health and Human Services, Department of / National Institutes of Health | 7/28/2009 |
| THE VANDERBILT UNIVERSITY | $1,515,506 | Grant | Trans-NIH Recovery Act Research Support: The overall purpose of the proposed research is to examine the influence of adverse interpersonal experiences on the construction of mood-activated negative self-schemas. Our theory is that such events constitute learning trials for the paired association | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $1,099,386 | Grant | Trans-NIH Recovery Act Research Support: Contraceptive failure is the primary cause of unintended pregnancy in the United States. With obesity rates at epidemic proportions, any association between obesity and strategies that prevent undesired pregnancies constitutes a significant public health | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| CREIGHTON UNIVERSITY | $874,490 | Grant | Trans-NIH Recovery Act Research Support: Shedding of the airway epithelium with selective loss of columnar epithelial cells from their attachment to basal cells is a hallmark of all types of asthma. Indeed, chronic asthma is associated with widespread damage to the bronchial epithelium and with | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $896,912 | Grant | Trans-NIH Recovery Act Research Support: The renin-angiotensin system (RAS) is a hormonal cascade of major critical importance to the regulation of blood pressure, fluid and electrolyte balance and kidney function. Angiotensin II (Ang II), the main effector peptide of the RAS, acts at two major | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE/CWRU | $706,500 | Grant | Trans-NIH Recovery Act Research Support: Pre-mRNA alternative splicing is a common means by which cells generate multiple, functionally distinct isoforms from a single gene. Developmentally regulated splicing has been described individually for many genes, yet little is known about how programs | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $775,500 | Grant | Trans-NIH Recovery Act Research Support: In the US, congestive heart failure (HF) is a common and lethal disease with 500,000 patients being diagnosed, and with ~300,000 deaths each year. Sympathoexcitation plays a prominent role in disease progression. It is known that sympathoexcitation is inv | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| LOMA LINDA UNIVERSITY | $699,440 | Grant | Trans-NIH Recovery Act Research Support: Overuse of salt is common by pregnant women due to physiological and pathophysiological changes during pregnancy. A strong relationship between high salt diet and increased blood pressure (BP) has been demonstrated. Although a number of studies have demon | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| RECINTO UNIVERSITARIO MAYAGUEZ | $416,209 | Grant | Trans-NIH Recovery Act Research Support: Weight control does not seem to be an effective answer to the increasing incidence of obesity as studies have shown that within five years most people have regained whatever weight they lost. Finding a solution to childhood overweight/obesity is especial | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF SOUTH ALABAMA | $711,300 | Grant | Trans-NIH Recovery Act Research Support: VENTILATOR INDUCED LUNG INJURY CAN CONTRIBUTE TO THE MORTALITY OF PATIENTS WITH ACUTE LUNG INJURY. THESE STUDIES WILL DETERMINE THE MECHANISMS BY WHICH ALVEOLAR MACROPHAGES AMPLIFY THE MECHANICAL STRITCH INDUCED PERMEABILITY RESPONSE IN THE ALVEOLAR CAPIL | Health and Human Services, Department of / National Institutes of Health | 5/30/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $1,537,979 | Grant | Trans-NIH Recovery Act Research Support: Cellular adhesion molecules (CAMs) may play a key role in atherosclerotic development. Soluble intracellular adhesion molecule (ICAM)-1 relates to clinical coronary heart disease in older people, mostly in case-control designs. Plausible pathways have bee | Health and Human Services, Department of / National Institutes of Health | 6/21/2009 |
| DUKE UNIVERSITY | $779,601 | Grant | Trans-NIH Recovery Act Research Support: Contraction of cardiac and skeletal muscle depends in large part on the amount of calcium released from the intracellular calcium store called the sarcoplasmic reticulum (SR).The regulation of this SR calcium is therefore fundamental to heart and muscle p | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| THE VANDERBILT UNIVERSITY | $775,000 | Grant | Trans-NIH Recovery Act Research Support: Tightly regulated cellular trafficking is a critical factor governing immune responses such as pathogen clearance and autoimmunity. Na+?ve T cell migration is limited to a series of peripheral secondary lymphoid organs interconnected via blood and lymphat | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $922,118 | Grant | Trans-NIH Recovery Act Research Support: Idiopathic pulmonary fibrosis (IPF) is a progressive and usually fatal disease of unknown etiology. The median survival after diagnosis is approximately 3 years, with outcomes being largely unaffected by current therapies. Improved understanding of the bi | Health and Human Services, Department of / National Institutes of Health | 5/30/2009 |
| WAYNE STATE UNIVERSITY (INC) | $911,617 | Grant | Trans-NIH Recovery Act Research Support: This proposal is focused on increasing our understanding of the role of sensory nerves that respond to changes in melabolite concentration in the active muscles and thos that sense changes in blood pressure in mediating the abnormal responses to exercise | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $1,325,206 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this project is to understand the roles of vascular and innate immune cell PAR signaling in inflammation using mouse genetic models. Proposed experiments on the role of PAR1 signaling in innate immune cells address how thrombin signali | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $2,801,921 | Grant | Trans-NIH Recovery Act Research Support: Millions of Americans develop chest pain suggestive of coronary heart disease each year and often require non-invasive diagnostic testing. However, currently available tests are imprecise, robust evidence regarding optimal test choice is limited, and test | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $1,018,919 | Grant | Trans-NIH Recovery Act Research Support: Despite a reduction in the incidence of HIV-associated dementia (HAD) in the era of Highly Active Anti-Retroviral Therapy (HAART), the prevalence of HAD is increasing, as is the frequency of minor cognitive diagnoses in HIV-positive patients. Although HA | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| AR CHILDRENS HOSPITAL RESEARCH INSTITUTE | $441,724 | Grant | Trans-NIH Recovery Act Research Support: Autism is a behavioral condition defined by deficient social interaction, language and communication, and play. Children with autism can exhibit a number of behaviors including severe tantrums, noncompliance, destructiveness, and self-injury. They may req | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| MICHIGAN STATE UNIVERSITY | $1,932,530 | Grant | Trans-NIH Recovery Act Research Support: This proposal is a revised version of an R01 application for a comprehensive five-year case-control study of CP (New Paradigms of CP Etiology 1R01NS055101). We now propose to perform a two year case-control study that focuses centrally on one rich source | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $743,905 | Grant | Trans-NIH Recovery Act Research Support: 1. We synthesized a novel set of non-toxic compounds that kill proliferating and nonproliferating glioma cells residing in perinecrotic tumor microenvironments. 2. We are completing evaluation of the efficacies of these agents in an in vivo murine (NGS) | Health and Human Services, Department of / National Institutes of Health | 8/21/2009 |
| WASHINGTON UNIVERSITY, THE | $822,896 | Grant | Trans-NIH Recovery Act Research Support: We believe that our most recent work studying the electrical properties of neurons of the brain represents abreakthrough in understanding how potassium channels control the excitability of neuronal electrical activity,and may have a significant impact on | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| UNIVERSITY OF UTAH, THE | $2,831,343 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The goal of the proposed BRP is to make wireless neural interface technology a turnkey technology that can be disseminated to the neuroscience and clinical research communities, that will generate validation data for u | Health and Human Services, Department of / National Institutes of Health | 7/27/2009 |
| BROWN UNIVERSITY IN PROVIDENCE IN STATE OF RI AND PROVIDENCE PLANTATIONS | $879,098 | Grant | Trans-NIH Recovery Act Research Support: TRPV1 channels are ligand- and heat-gated ion channels that have a calcium permeability comparable to NMDAR channels. First identified and cloned in primary sensory afferent neurons in the peripheral nervous system, mounting evidence supports the expressi | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $762,463 | Grant | Trans-NIH Recovery Act Research Support: Despite the high prevalence of migraine in the general population, our understanding of the underlying mechanisms remains incomplete. A variety of theories focused on peripheral neural or neurovascular mechanisms have been put forward, but none of these h | Health and Human Services, Department of / National Institutes of Health | 7/19/2009 |
| ST. JUDE CHILDREN'S RESEARCH HOSPITAL | $462,049 | Grant | Trans-NIH Recovery Act Research Support: The goal of the proposed research is to achieve in-depth understanding of the molecular mechanisms underlying the CNS pathogenesis in GM1-gangliosidosis, a catastrophic neurodegenerative lysosomal storage disease (LSD) caused by deficiency of 2-galactosid | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| HENRY FORD HEALTH SYSTEM | $732,500 | Grant | Trans-NIH Recovery Act Research Support: Gliomas, the most frequent primary brain tumors, exhibit very poor prognosis which is largely due to their highly infiltrative nature. Genetic and biochemical studies have demonstrated that gliomagenesis involves stepwise accumulation of genetic alteratio | Health and Human Services, Department of / National Institutes of Health | 9/20/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $597,884 | Grant | Trans-NIH Recovery Act Research Support: To determine if a subset of autism spectrum (ASD) disease is caused by mitochondrial dysfunction, we propose to survey patient lymphoblastoid cell lines for those harboring nuclear DNA (nDNA) copy number variants (CNVs) or mitochondrial DNA (mtDNA) mutati | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $1,049,999 | Grant | Trans-NIH Recovery Act Research Support: Autism Spectrum Disorders (ASD) represents a group of severe, highly heritable, neurobehavioral syndromes with heterogeneous phenotype. The clinical features of autistic children are notable for an unawareness of their surrounding environment, impaired la | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON | $125,460 | Grant | Trans-NIH Recovery Act Research Support: The goal of the proposed research is to examine the prevalence of obesity and the relationship between obesity, muscle strength, and disability among older Mexican Americans in the United States (U.S.) and elders from Latin America and the Caribbean. Very | Health and Human Services, Department of / National Institutes of Health | 5/18/2009 |
| UNIVERSITY OF CHICAGO, THE | $127,920 | Grant | Trans-NIH Recovery Act Research Support: Normal aging can reduce memory resolution, or the degree of clarity and sensory detail in subjectively experienced recollections. However, we do not know the degree that these reductions are due to a primary loss of resolution abilities, diminished strate | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $147,600 | Grant | Trans-NIH Recovery Act Research Support: This project, entitled ?Longitudinal study of membrane lipids: Pre-clinical Alzheimer?s disease biomarkers?, will: (1) Characterize the between-individual variability of serum lipids (e.g. ceramides, sphingomyelins, 24S-hydroxycholesterol (24S-OHC), or F2 | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC. | $125,020 | Grant | Trans-NIH Recovery Act Research Support: With the widespread use of antiretroviral therapy, non-AIDS-related conditions such as cardiovascular disease and chronic kidney disease have emerged as important risk factors for mortality in the aging HIV-infected population. In the United States, cardi | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $151,000 | Grant | Trans-NIH Recovery Act Research Support: Herpes simplex virus (HSV), and likely all herpesviruses, use two methods to enter cells: (1) direct fusion: the virus fuses its lipid bilayer with the plasma membrane at the cell surface and (2) receptor-mediated endocytosis (RME): the virus fuses with a | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| WAKE FOREST UNIVERSITY | $148,000 | Grant | Trans-NIH Recovery Act Research Support: Beta-agonists are the most common medication used for treatment of acute asthma attacks. Inter-individual responses to beta-agonist are variable, and there is strong evidence that genetics play an important role in determining these inter-individual respo | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| CARY INSTITUTE OF ECOSYSTEM STUDIES, INC. | $162,507 | Grant | Trans-NIH Recovery Act Research Support: Anthropogenic climate change over the past century has led to global temperatures consistently above those historically recorded. One of the most discussed, but perhaps least understood consequences of global climate change, is its effect on infectious di | Health and Human Services, Department of / National Institutes of Health | 5/19/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $177,749 | Grant | Trans-NIH Recovery Act Research Support: T helper cells differentiate into different subsets, which are responsible for controlling the outcome of an immune response. For example, Th1 cells direct the immune response against viruses and intracellular bacteria, while Th17 cells are required to er | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| CORNELL UNIVERSITY, INC | $154,000 | Grant | Trans-NIH Recovery Act Research Support: Efficient discrimination between innocuous and pathogenic antigens forms the basis of effective immune function. Appropriate restraint of immune responsiveness is particularly important within the unique environment of the liver since intrahepatic cells a | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER | $148,500 | Grant | Trans-NIH Recovery Act Research Support: The overall purpose of this project is to understand the mechanism by which aspirin exerts anti-cancer effects in breast and colon cancer cell types and determine its ability to enhance the efficacy of DNA damaging anti-cancer drugs. | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $152,000 | Grant | Trans-NIH Recovery Act Research Support: Smoking research and intervention efforts have substantially neglected middleaged and older adults, with older women who smoke particularly underserved. Yet, cigarette smoking is a significant cause of morbidity and mortality among women in midlife and ag | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| RAND CORPORATION, THE | $294,369 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Dr. Rajeev Ramchand is an early career investigator pursuing the A-START grant mechanism to facilitate his entry into the area of drug abuse research on HIV/AIDS. His proposed research is a feasibility study that aims | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| BROWN UNIVERSITY IN PROVIDENCE IN STATE OF RI AND PROVIDENCE PLANTATIONS | $403,959 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): A fundamental understanding of how the sigma-1 receptor is regulated at the protein level, and how this impacts its function, is still missing. This is important because the sigma receptors represent a novel class of p | Health and Human Services, Department of / National Institutes of Health | 5/18/2009 |
| VIRGINIA COMMONWEALTH UNIVERSITY | $149,500 | Grant | Trans-NIH Recovery Act Research Support: Cannabinoid CB1 receptors in the CNS mediate psychoactive effects of marijuana and are a critical component of the endogenous cannabinoid system, which is involved in motivation and reward, motor control, appetite, learning and memory, and pain and thermo | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $463,500 | Grant | Trans-NIH Recovery Act Research Support: Cognitive and motor impairments seen in methamphetamine (meth) dependence are often unrelated to drug use parameters such as length of abstinence, lifetime consumption, chronicity, mode of delivery, etc. This suggests the possibility of individual differe | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| HOUSE EAR INSTITUTE INC | $356,200 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of this research is to develop stimulation strategies that increase the number of effective channels for cochlear implant (CI) users. Most CI users have great difficulty in challenging listening conditions (e.g., background noise, competi | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $147,999 | Grant | Trans-NIH Recovery Act Research Support: Stem cell therapy offers a promising approach to providing an advanced and reliable therapeutic strategy to repair craniofacial defects. However, fundamental processes determining stem cell differentiation are not well understood. The overall goal of the | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF FLORIDA | $217,844 | Grant | Trans-NIH Recovery Act Research Support: The bacterium Streptococcus mutans is the primary causative agent of dental caries, which remains the most common chronic disease among children and is untreated in up to 30% of adults over 35 yrs-old. When transiently introduced into the bloodstream foll | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF KENTUCKY | $220,722 | Grant | Trans-NIH Recovery Act Research Support: Chronic soft tissue oral wounds (e.g., Mucositis, aphthous stomatitis and periodontal disease) can be very painful and often are to develop a simple to apply polymeric barrier for the enhanced healing of these oral wounds. It is hypothesized that by rinsi | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF MARYLAND | $150,000 | Grant | Trans-NIH Recovery Act Research Support: Abnormal physiological states in the erythrocytes or in the ambient plasma affect the ability of red blood cells (RBCs) to deform and thus to pass through the networks of microvessels. This lowers the amount of oxygen delivered to the body's tissues with | Health and Human Services, Department of / National Institutes of Health | 4/30/2009 |
| UNIVERSITY OF ROCHESTER | $145,783 | Grant | Trans-NIH Recovery Act Research Support: This small project will complete testing and development of an agent-based computational model of multi-cell migration in the classic scratch wound assay. The model attempts to mimic experiments on a simple immortal cell type (3T3-L1 fibroblasts) without | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| DREXEL UNIVERSITY | $142,103 | Grant | Trans-NIH Recovery Act Research Support: The mechanical environment is critical to the structural integrity and normal function of many cell types. Altered cell mechanics can be either a cause or effect of a pathologic state. Cell mechanics are intricately coupled to cell biochemistry, yet the m | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| THE VANDERBILT UNIVERSITY | $155,000 | Grant | Trans-NIH Recovery Act Research Support: In the past decade, we have witnessed tremendous advances in the development and implementation of noninvasive molecular imaging in order to phenotypically characterize cancers through early detection and staging using molecular imaging. Among these techn | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| DEPARTMENT OF EDUCATION, SOUTH CAROLINA | $63,000 | Grant | Trans-NIH Recovery Act Research Support: Determination of mode of action of PFOS on decreased antibody production to better assess human health risk from environmental exposure to this compound. | Health and Human Services, Department of / National Institutes of Health | 5/19/2009 |
| UNIVERSITY OF NORTH CAROLINA AT GREENSBORO | $139,500 | Grant | Trans-NIH Recovery Act Research Support: !Mothers' Part-Time Employment! is an analysis of NICHD ECCRN data (focal child birth through 5th grade) to identify the conditions under which mother's part-time employment facilitates family functioning and the conditions under which mother's part-time | Health and Human Services, Department of / National Institutes of Health | 5/06/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $153,120 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This is a proposal to study the influence of marital processes on childbearing practices in a society just beginning a dramatic fertility transition. This study will focus on the most significant aspects of fertility d | Health and Human Services, Department of / National Institutes of Health | 8/24/2009 |
| NORTHWESTERN UNIVERSITY | $167,375 | Grant | Trans-NIH Recovery Act Research Support: It is well recognized that African American women have a higher rate, larger size and worse morbidity of uterine leiomyomata (ULM) than white women. Identification of the genetic variants and differences in gene expression in ULM of different races will g | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| BOSTON COLLEGE, TRUSTEES OF | $156,500 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this project is to determine significant attitudes and beliefs that are associated with reporting of dating violence in college women. Achieving this goal will guide research developing and testing effective prevention and intervention str | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $160,592 | Grant | Trans-NIH Recovery Act Research Support: Advances in perinatal care have led to decreased mortality of premature infants; however, these infants remain at high risk for cerebral palsy (CP), developmental delay, and sensory-motor deficits in infancy and learning disabilities, dyslexia, and hypera | Health and Human Services, Department of / National Institutes of Health | 4/30/2009 |
| RAND CORPORATION. THE | $186,516 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The long-term objective of this study is to understand intergenerational transmission of tobacco-related health risks. It focuses on the role of maternal-child exposure to maternal smoking during pregnancy (SDP). There | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| UMDNJ-ROBERT WOOD JOHNSON MEDICAL SCHOOL | $151,850 | Grant | Trans-NIH Recovery Act Research Support: Growth cone guidance is critical for the establishment of appropriate connectivity between neurons and failures in this process can result in psychiatric and neurological disease. Several extracellular guidance cues and their receptors have been implicat | Health and Human Services, Department of / National Institutes of Health | 4/30/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $159,584 | Grant | Trans-NIH Recovery Act Research Support: The proposed study examines outcomes for injured children in the United States. The investigators will use nationally representative datasets to compare severity adjusted outcomes for children treated at pediatric trauma centers, adult trauma centers, an | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| CHARLES DREW UNIVERSITY OF MEDICINE AND SCIENCE | $140,998 | Grant | Trans-NIH Recovery Act Research Support: This project will utilize geographic analysis techniques to create measures that detect the influence of key aspects of the local social and built environmental on cardiovascular disease management at the individual level. The specific community character | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| CORNELL UNIVERSITY, INC | $140,957 | Grant | Trans-NIH Recovery Act Research Support: The goal of this research is to explore whether gene expression in lung tissue is modulated by antioxidant status. Chronic Obstructive Pulmonary Disease (COPD) is characterized by the development of irreversible airflow limitation and is the fourth leadin | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| RUSH UNIVERSITY MEDICAL CENTER | $150,000 | Grant | Trans-NIH Recovery Act Research Support: Long-term objectives of the proposed work are to find out what new pathogenic mechanisms are involved in initiation and progression of idiopathic lung fibrosis (IPF) with the intention to discover new molecular targets that can be used as therapeutic tool | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $177,583 | Grant | Trans-NIH Recovery Act Research Support: The molecular and cellular pathways involved in tobacco smoke induced chronic obstructive pulmonary disease (COPD) pathogenesis are poorly understood. Autophagy is an intrinsic cellular program for the vesicular proteolytic turnover of proteins and dysfun | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| MCLEAN HOSPITAL CORPORATION, THE | $158,000 | Grant | Trans-NIH Recovery Act Research Support: Relative neuronal vulnerability is a universal yet poorly understood feature of neurodegenerative diseases. In Parkinson's disease (PD), dopaminergic (DA) neurons in the substantia nigra (SN; A9) are particularly vulnerable, whereas adjacent DA neurons wi | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $160,592 | Grant | Trans-NIH Recovery Act Research Support: Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic neurons in the ventral midbrain (VM), resulting in striatal dopamine (DA) depletion. The neuronal loss is severe for DA neurons in the substantia nigra (SN), while t | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| RENSSELAER POLYTECHNIC INSTITUTE | $143,326 | Grant | Trans-NIH Recovery Act Research Support: The transmission of infectious prions from cattle to humans continues to threaten our society. Prions form multiple infectious strain conformations that have unique capacities to overcome species barriers through an unknown mechanism. This proposed resear | Health and Human Services, Department of / National Institutes of Health | 5/12/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $74,000 | Grant | Trans-NIH Recovery Act Research Support: There is overwhelming clinical evidence of the interactions between sleep and epilepsy, but the literature on seizure prediction has largely disregarded the effects of state of vigilance (SOV) on seizure generation. Existing seizure prediction algorithms | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| SOUTHERN ILLINOIS UNIVERSITY | $218,250 | Grant | Trans-NIH Recovery Act Research Support: Prostate cancer is the second most common form of cancer in American males. Genotoxic agents, such as ionizing radiation, ultraviolet light, and oxidizing compounds that are generated in normal cellular processes, can damage DNA and are a major cause of c | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF MASSACHUSETTS | $201,318 | Grant | Trans-NIH Recovery Act Research Support: Neural tube and orofacial defects are common congenital malformations in humans. Craniofacial birth defects strike an average of 1 in 750 newborns and they are for the most part multifactorial in their pathogenesis, having both genetic and environmental c | Health and Human Services, Department of / National Institutes of Health | 4/29/2009 |
| NORTHERN KENTUCKY UNIVERSITY | $203,100 | Grant | Trans-NIH Recovery Act Research Support: The overall purpose of the research grant is the computer-assisted discovery of novel inhibitors of the enzyme sacro/endoplasmic reticulum Ca 2+ -ATPase (SERCA). Those inhibiotrs are valuabale research tools for the sudy of the enzyme's role in physiolog | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| KENT STATE UNIVERSITY | $217,570 | Grant | Trans-NIH Recovery Act Research Support: Despite significant advances in the study of oogenesis, there are major gaps in our understanding of how mammalian meiosis is regulated through protein interactions and signaling systems. Recently it has become clear that members of the 14-3-3 protein fam | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| FLORIDA INTERNATIONAL UNIVERSITY | $1,286,571 | Grant | Trans-NIH Recovery Act Research Support: ?Brief Intervention for Marijuana Use among Latino Youth is a two-year research project designed to develop and test a school-based, brief intervention for marijuana using, Hispanic/Latino 10th & 11th graders. Clinical trials support the effectiveness of | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| UNIVERSITY OF MISSOURI SYSTEM | $371,334 | Grant | Trans-NIH Recovery Act Research Support: Every day over 6800 new infections takes place and 5700 persons die from Human immunodeficiency virus infections (HIV/AIDS) worldwide, mostly because of inadequate access to HIV prevention and treatment services. Women who acquired HIV-1 through vaginal i | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| CLAREMONT GRADUATE UNIVERSITY | $406,758 | Grant | Trans-NIH Recovery Act Research Support: associative effects have been shown to consistently predict level of use but have not yet been empirically linked to likely neural substrates. The application of associative memory concepts from basic science research suggests that one?s behavior at any m | Health and Human Services, Department of / National Institutes of Health | 7/30/2009 |
| UTAH STATE UNIVERSITY | $319,069 | Grant | Trans-NIH Recovery Act Research Support: Trajectories of psychosocial and functional change during late life reflect a combination of age-related, disability-related, and mortality-related processes. The proposed research examines heterogeneity of change across multiple domains of function (ph | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $365,476 | Grant | Trans-NIH Recovery Act Research Support: Aging is a prominent and independent risk factor for a wide spectrum of diseases including organ failure, cancer, dementia, hypertension, diabetes and arthritis. During the past 50 years, the number of Americans age 65 years or older has nearly tripled fr | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| UNIVERSITY OF ROCHESTER | $346,143 | Grant | Trans-NIH Recovery Act Research Support: During aging there is a progressive decline in the function of most organs and tissues. Our data show that the ECM protein, fibronectin (FN), regulates the deposition and turnover of other ECM molecules including collagen I, collagen III, thrombospondin | Health and Human Services, Department of / National Institutes of Health | 5/20/2009 |
| UNIVERSITY OF PITTSBURGH THE | $336,250 | Grant | Trans-NIH Recovery Act Research Support: MDSCs will be isolated from Ercc1-/Delta mice and wt littermates (Ercc1+/ Delta) (at 1, 3, 5 and 7mths of age. We will also isolate MDSCs from the Ercc1-/- mice between 14 and 28 days of age. The hind limb muscles (gastrocnemius, soleus and tibialis anter | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK | $347,270 | Grant | Trans-NIH Recovery Act Research Support: ARRA - TRANS-NIH RECOVERY ACT RESEARCH SUPPORT - AlzheimerG??s disease is characterized by neurodegeneration, which leads to cognitive decline. Mutations in the amyloid precursor protein (APP) gene have been correlated with early-onset familial Alzheim | Health and Human Services, Department of / National Institutes of Health | 5/13/2009 |
| THOMAS JEFFERSON UNIVERSITY | $424,875 | Grant | Trans-NIH Recovery Act Research Support: The proposed research addresses the development of a vaccine that would be effective for the control and prevention of Nipah virus (NiV) infection, which poses a serious public health as well as veterinary health hazard in the U.S. NiV is a newly describe | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF OKLAHOMA | $374,793 | Grant | Trans-NIH Recovery Act Research Support: The bacterial stringent response system that controls transitions between growth and non-growth states in E. coli has not been evaluated with respect to its role in animal colonization. The stringent response to nutrient limitation involves the rapid accu | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON | $412,500 | Grant | Trans-NIH Recovery Act Research Support: We propose to test the hypothesis that catabolic antibodies play an important innate defense role in protecting against Staphylococcus aureus infections. S. aureus is an opportunistic pathogen that colonizes the skin (primarily the anterior nasal vestibul | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $466,979 | Grant | Trans-NIH Recovery Act Research Support: Neutrophils are the most effective barrier in preventing the invasion and spreading of microorganisms within the human body. Failure of neutrophils to promptly arrive at sites of infection or inflammation can result in uncontrollable infections, while ove | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $488,500 | Grant | Trans-NIH Recovery Act Research Support: In an effort to provide additional therapeutic options to patients with drug resistant virus or untoward toxicities on existing therapy, new drugs with potent antiretroviral activity are being developed that target and block HIV-1 entry into cells. Vicriv | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | $417,054 | Grant | Trans-NIH Recovery Act Research Support: Ricin is a plant toxin produced by the castor bean (Ricinus communis) that is extremely toxic to mammalian cells and is classified as a select agent by the US Department of Health and Human Services (HHS) and a category B priority pathogen by the Center f | Health and Human Services, Department of / National Institutes of Health | 5/04/2009 |
| PURDUE UNIVERSITY | $419,375 | Grant | Trans-NIH Recovery Act Research Support: Salmonella enterica serovar Typhimurium causes mild gastroenteritis and more severe systematic infections in both humans and domestic animals. It encodes two specialized type III protein secretion systems that are required for bacterial invasion into epit | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| UNIVERSITY OF PITTSBURGH THE | $413,535 | Grant | Trans-NIH Recovery Act Research Support: This study is aimed to elucidate the significant effect and the mechanisms of RNA editing enzyme ADAR1 (Adenosine Deaminase Acting on RNA -1). ADAR1 is an essential protein required for cell survival and embryonic development. Knockout of the gene en | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF CONNECTICUT | $420,000 | Grant | Trans-NIH Recovery Act Research Support: The relevance of this project to public health is based on the need for a CMV vaccine to protect infants, children and immune compromised individuals. Susceptible individuals share significant challenges for vaccination, as they are less competent to gene | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $444,600 | Grant | Trans-NIH Recovery Act Research Support: Gender factors influencing susceptibility to influenza: The overarching aim of this proposal is to develop an animal model that enables us to test the hypothesis that gender differences in susceptibility to influenza virus infection reflect differential r | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $411,464 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This project will define the essential mechanics of macropinosome closure. Macropinocytosis and morphologically analogous movements of membrane and the actin cytoskeleton are important in epithelial physiology and host | Health and Human Services, Department of / National Institutes of Health | 7/21/2009 |
| MONTANA STATE UNIVERSITY, INC | $388,638 | Grant | Trans-NIH Recovery Act Research Support: The purpose of the studies in this project is to identify components of the immune response that are targeted for inhibition by a rotavirus protein NPS1. We have nearly completed analysis of our dataset obtained from the SILAC experimental protocol. We ar | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| UNIVERSITY OF KENTUCKY | $402,875 | Grant | Trans-NIH Recovery Act Research Support: The causative agent of Lyme disease, Borrelia burgdorferi, can persistently infect humans and other mammalian hosts for great lengths of time. Understanding the mechanisms by which Lyme disease spirochetes establish and maintain chronic infections will be | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| UNIVERSITY OF CONNECTICUT | $420,375 | Grant | Trans-NIH Recovery Act Research Support: Allergic mice are able to turn off their asthma. They appear to make a specific type of B lymphocyte that is capable of creating regulatory T lymphocytes, which inhibit airway inflammation. Better understanding of this process in mice may help us to learn | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $446,961 | Grant | Trans-NIH Recovery Act Research Support: This pilot project will define the innate immune pathways critical for host response to a Category A biodefense pathogen, Rift Valley Fever Virus (RVFV), by elaborating molecular components of early cellular responses to RVFV in vitro, using established h | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| BAYLOR COLLEGE OF MEDICINE | $422,125 | Grant | Trans-NIH Recovery Act Research Support: This project studies the role of CXCL16 in the development of atherosclerosis. Despite considerable progress in understanding the role of inflammation in atherosclerosis, it remains unclear what mechanisms drive the inflammation and how it is regu | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $416,480 | Grant | Trans-NIH Recovery Act Research Support: Infectious diseases are one of the leading causes of death worldwide. Emergence of antibiotic resistant bacteria causes serious concerns even for infections that once were treatable with antibiotics or other antimicrobial agents. A notable example is a re | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| CLEMSON UNIVERSITY | $398,108 | Grant | Trans-NIH Recovery Act Research Support: Entamoeba histolytica is the causative agent of amoebic dysentery and liver abscess. Since this pathogen is categorized as a Class B bioterrorism agent, there is elevated priority to understand the molecular and cellular mechanisms that regulate its virul | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $387,799 | Grant | Trans-NIH Recovery Act Research Support: This project is being supported with funds from the American Recovery and Reinvestment Act, which may involve a reduction in the research aims and scope. If necessary, a revised abstract will be posted soon and this notice removed. DESCRIPTION (provided | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| WAYNE STATE UNIVERSITY (INC) | $369,156 | Grant | Trans-NIH Recovery Act Research Support: A. Specific Aims have not changed from the original proposal: 1. Optimizing the amplicon for HRM analysis. 2. To resolve similar dMelt profiles of closely related species. 3. To validate the optimized HRM analysis by testing the reproducibility of dMelt c | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| BOSTON COLLEGE, TRUSTEES OF | $430,375 | Grant | Trans-NIH Recovery Act Research Support: Forward genetics has been instrumental to understand gene function in well-studied model organisms such as yeast, fruitfly, the worm, and zebrafish. However, molecular genetic mapping methods used in these model systems are time-consuming and laborious. M | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| CHILDREN'S HOSPITAL CORPORATION, THE | $479,202 | Grant | Trans-NIH Recovery Act Research Support: Current approaches to the diagnosis of tuberculosis (TB) are not optimal. The tuberculin skin test has low sensitivity and specificity. Newer interferon-gamma release assays are more specific but lack sensitivity in some settings, are expensive, and requi | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| UNIVERSITY OF PITTSBURGH THE | $416,625 | Grant | Trans-NIH Recovery Act Research Support: Bacillus anthracis is an important human pathogen that is the etiological agent of anthrax in humans and a potential biological weapon. Two large plasmids, pXO1 and pXO2, play a major role in the virulence of this organism. Gene transfer can frequently o | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| EASTERN VIRGINIA MEDICAL SCHOOL | $394,625 | Grant | Trans-NIH Recovery Act Research Support: Staphylococcus aureus is a major health threat in the United States causing skin abscesses, bone infections, joint infections, pneumonias, heart infections, post-operative infections, and infections of implanted devices. Of international concern is the ra | Health and Human Services, Department of / National Institutes of Health | 5/04/2009 |
| WASHINGTON UNIVERSITY, THE | $418,000 | Grant | Trans-NIH Recovery Act Research Support: Project is currently on a No Cost Extension through 7/31/12. Many aspects of gene function are coordinated by changes in the epigenome, which include dynamic revisions of chromatin modifications, genome packaging, subnuclear localization, and chromosome c | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $412,013 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Mucosal surfaces are constantly exposed to antigens, infectious agents and the indigenous microbiota. Sequential infections are being increasingly recognized to be a determining factor in the outcome of an immune respo | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF WASHINGTON | $429,000 | Grant | Trans-NIH Recovery Act Research Support: In preliminary studies, we have demonstrated that A/J mice do not adequately control mucosal Salmonella infection and suffer persistent mucosal infection and inflammation, which is associated with increased IL-17 production. Using this model we will inv | Health and Human Services, Department of / National Institutes of Health | 7/23/2009 |
| THE CHILDRENS HOSPITAL LOS ANGELES | $400,000 | Grant | Trans-NIH Recovery Act Research Support: The intestinal epithelium is continuously exposed to high concentrations of bacteria. Intestinal epithelial cells (enterocytes) express pathogen pattern recognition Toll-like receptors (TLR), and produce inflammatory factors in response to stimulation wit | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $486,625 | Grant | Trans-NIH Recovery Act Research Support: Shigella sp. cause diarrhea and dysentery by invasion and spread through the colonic mucosa. Shigella sp. are CDC/NIAID priority pathogens. In the cell cytoplasm, Shigella move to the cell periphery and into adjacent cells by assembling propulsive actin t | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF PITTSBURGH THE | $416,625 | Grant | Trans-NIH Recovery Act Research Support: Chlamydia trachomatis infections are the leading cause of involuntary infertility and ectopic pregnancy in women. Although antibiotic treatment cures infection, it does not ameliorate the inflammatory process that leads to the development of disease. We | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF ILLINOIS | $431,750 | Grant | Trans-NIH Recovery Act Research Support: This R21 exploratory proposal uses an integrated target-oriented approach in the rational development of drugs that may effectively shorten the duration of therapy in tuberculosis (TB) and/or improve the treatment of multi-drug resistant TB. According to | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC. | $412,500 | Grant | Trans-NIH Recovery Act Research Support: Hantavirus cardio pulmonary syndrome (HPS) cased by rodent born category A virus has a mortality of fifty percent. The studies on G?cap snatchingG? will help in understanding the mechanism of hantavirus pathogenesis, identification of targets for the anti | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF ARIZONA | $415,823 | Grant | Trans-NIH Recovery Act Research Support: Mosquito-borne diseases impact millions of people around the globe. Malaria alone affects 40% of the world's population and kills over one million people annually, primarily young children. Unfortunately the primary control measures, particularly drugs an | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| VIRGINIA COMMONWEALTH UNIVERSITY | $315,860 | Grant | Trans-NIH Recovery Act Research Support: Herpes simplex virus is a common cause of infections and can cause serious complications such as neonatal infections and fatal encephalitis. The purpose of this research is to determine how the herpes simplex virus initiates infection in humans by studyin | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |
| UNIVERSITY OF KENTUCKY | $408,375 | Grant | Trans-NIH Recovery Act Research Support: Yersinia pestis is the causative agent of plague in humans. We have discovered a chromosomally located bicistronic operon that encodes a novel pair of interacting surface proteins called YadB and YadC (collectively referred to as YadB-C) that belong to th | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $400,855 | Grant | Trans-NIH Recovery Act Research Support: Mycoplasma pneumoniae is major cause of respiratory infections including community acquired pneumonia, and the organism is an established cause of extrapulmonary complications such as encephalitis. At present three classes of drugs are used to treat M. p | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| THOMAS JEFFERSON UNIVERSITY | $424,875 | Grant | Trans-NIH Recovery Act Research Support: The molecular mechanism involved in the tumor suppressing function of Fhit and Nit1 is not clear. Previous studies have shown that ectopic expression of Fhit or Nit1 can induce apoptosis in tumor cells, which requires caspase activation but is independen | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| DUKE UNIVERSITY | $353,375 | Grant | Trans-NIH Recovery Act Research Support: Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that primarily affects young women and powerfully exemplifies the importance of sex as a determinant of immune-mediated disease. Indeed, among autoimmune and inflammatory diseases, SLE | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| CEDARS-SINAI MEDICAL CENTER | $446,875 | Grant | Trans-NIH Recovery Act Research Support: Homeostasis in the intestinal mucosa is maintained by a delicate balance between physiological and pathophysiological inflammation that assures efficient response against pathogenic organisms and avoidance of hyperresponsiveness to the commensal flora. Di | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $522,225 | Grant | Trans-NIH Recovery Act Research Support: We aim to develop new chemical tools optimized for structural studies of the HIV co-receptor CXCR4, attempting crystallization and structural determination of the receptors and its complexes. Chemical tools will be designed and optimized for stabilizing, | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF NEW MEXICO | $414,063 | Grant | Trans-NIH Recovery Act Research Support: Recent studies have identified a promoter polymorphism in C-reactive protein (CRP) as a susceptibility locus for systemic lupus erythematosus (SLE). Protective haplotypes associated with higher CRP levels confer a 2- 3-fold reduced risk of SLE. This propo | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $373,725 | Grant | Trans-NIH Recovery Act Research Support: The interaction of keratinocytes and epidermal nerve fibers has emerged as an important interface in sensory transduction and pain and may be a factor in the mechanisms underlying painful peripheral neuropathies. Keratinocytes express receptors and channe | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| SOUTH CAROLINA RESEARCH FOUNDATION | $12,028 | Grant | Trans-NIH Recovery Act Research Support: CHONDROPROTECTIVE ACTIVITY OF POMEGRANATE EXTRACT Osteoarthritis (OA) is the most common musculoskeletal disease among the aging population in the United States and throughout the world. OA is characterized by degeneration of articular cartilage of the jo | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| UNIVERSITY OF MIAMI | $420,750 | Grant | Trans-NIH Recovery Act Research Support: The repair of human peripheral nerve injuries using traditional surgical techniques has limited success, particularly when a damaged nerve segment needs to be replaced. Nerve regeneration is critically dependent on the presence of Schwann cells, and the | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $440,877 | Grant | Trans-NIH Recovery Act Research Support: This award funded by the National Institute of Neurological Disorders and Stroke is entitled, ?Common-Path OCT for Real Time Imaging in Minimally Invasive Neurosurgery.? The main objective of the award is to develop and test ?laser-guided? smart neurosurg | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $416,786 | Grant | Trans-NIH Recovery Act Research Support: Adaptive brain plasticity after stroke is critically dependent upon behavioral experience. Manipulations of experience, including rehabilitative training, are emerging as a core strategy for driving functionally appropriate brain reorganization after brai | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| NEW YORK UNIVERSITY (INC) | $317,405 | Grant | Trans-NIH Recovery Act Research Support: The greatest barrier to development of efficacious vaccines against tuberculosis is the ability of Mycobacterium tuberculosis to persist and to cause progressive infection despite development of an adaptive immune response. While partially-efficacious va | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| TEXAS BIOMEDICAL RESEARCH INSTITUTE | $847,754 | Grant | Trans-NIH Recovery Act Research Support: Over the last 25 years, the Acquired Immunodeficiency Syndrome (AIDS), caused by the Human Immunodeficiency Virus (HIV), has resulted in millions of death worldwide. Because HIV transmission occurs predominantly across mucosal surfaces, the ideal vaccine | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER | $144,800 | Grant | Trans-NIH Recovery Act Research Support: Obesity has emerged as a preeminent public health problem. In the United States, 66% of adults are overweight (BMI 25 to <30 kg/m2) and 33% are obese (BMI?30 kg/m2), representing a modern health crisis. Perhaps of even greater concern is the dramatic in | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| SRI INTERNATIONAL | $998,910 | Grant | Trans-NIH Recovery Act Research Support: This award addresses broad Challenge Area (06) Enabling Technologies and specific Challenge Topic 6- LM-101* Intelligent Search Tool for Answering Clinical Questions. Technology is developed to answer questions in English, where the answer must be inferr | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| DUKE UNIVERSITY | $953,758 | Grant | Trans-NIH Recovery Act Research Support: Chronic diseases of the brain such as Alzheimer's disease (AD) impact an estimated 5 million individuals in the US. While progress has been made in identifying specific mutated genes that initiate a neurodegenerative disease process, we have limited infor | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION | $999,999 | Grant | Trans-NIH Recovery Act Research Support: This application directly addresses the Broad Challenge Area (13): Smart Biomaterials-Theranostics, and the Specific Challenge Topic: Methods to Evaluate the Health and Safety of Nanomaterials. We are a uniquely qualified laboratory to address this challe | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| WASHINGTON UNIVERSITY, THE | $1,705,719 | Grant | Trans-NIH Recovery Act Research Support: This proposal is from Dr. Linda Sandell, a cartilage biologist in the Department of Orthopaedic Surgery and Dr. Jim Cheverud, a population geneticist in the Department of Anatomy and Neurobiology. We propose to identify genetically defined mouse models of | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $4,152,659 | Grant | Trans-NIH Recovery Act Research Support: The past years have seen tremendous advances in technology that have allowed us to gain powerful insight into the molecular and genetic determinants that drive cancer. However, by comparison, the rate at which this advanced knowledge has been translated i | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $271,044 | Grant | Trans-NIH Recovery Act Research Support: Pancreatic cancer is a lethal disease as manifested by rapid progression and early formation of regional and distant metastasis, and resistance to conventional therapies. The underlying molecular basis of pancreatic cancer progression and metastasis is un | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| HEALTH RESEARCH, INC. | $179,666 | Grant | Trans-NIH Recovery Act Research Support: While the positive association between socioeconomic status (SES) and health outcomes has been a consistent finding in health related research, the pathways that produce this association remain imperfectly understood. One pathway that has been hypothesiz | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| MONTEFIORE MEDICAL CENTER | $400,377 | Grant | Trans-NIH Recovery Act Research Support: The project will create and pilot an intensive, eight session, group cessation intervention designed to address the needs and concerns of smokers living with HIV/AIDS. It will be guided by the social cognitive theory model, the groups will be led by paire | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| ANGELO STATE UNIVERSITY | $312,151 | Grant | Trans-NIH Recovery Act Research Support: The long term goal of this project is to develop therapeutics that will result in the elimination of human immunodeficiency virus. The objective of this particular application, which represents a first step toward the attainment of our long term goal, is | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| REGENTS OF THE UNIVERSITY OF MINNESOTA | $415,250 | Grant | Trans-NIH Recovery Act Research Support: Opioids are an effective treatment for chronic pain, but repeated use can result in tolerance and physical dependence. These changes are thought to require activation of NMDA receptors and nitric oxide synthase (NOS), because blockade of either can preven | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $431,356 | Grant | Trans-NIH Recovery Act Research Support: The primary objective of the proposed research is to develop a rodent model of self administration (SA) in which drug consumption has delayed negative consequences. Self administration procedures in which the animals make responses that are reinforced by | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $325,000 | Grant | Trans-NIH Recovery Act Research Support: Drug addiction remains among the most costly neuropsychiatric disorders in terms of personal tragedy and overall societal economic burden. Drug self-administration paradigms in preclinical animal models for the evaluation of stimulant and opiate drugs hav | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| CREIGHTON UNIVERSITY | $388,475 | Grant | Trans-NIH Recovery Act Research Support: The senses of hearing and balance depend upon hair cells, the sensory receptors of the inner ear. Hair cells transduce mechanical stimuli into electrical activity. Loss of hair cells or damage to the transduction apparatus, the stereocilium bundle on the | Health and Human Services, Department of / National Institutes of Health | 6/02/2009 |
| UNIVERSITY OF TEXAS AT SAN ANTONIO | $390,255 | Grant | Trans-NIH Recovery Act Research Support: Insect-borne disease is a major world health problem, accounting for nearly 20% of the total world- wide infectious disease burden. Many of these diseases are capable of spreading to the United States. Because insects depend on chemical senses for host lo | Health and Human Services, Department of / National Institutes of Health | 5/01/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $405,625 | Grant | Trans-NIH Recovery Act Research Support: The primary purpose of this funding is to support the development and testing of a novel dysphagia treatment. Dysphagia is a commonly occurring and often chronic upper aerodigestive disorder that results from head and neck cancer treatments and neurologic | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| FLORIDA STATE UNIVERSITY, THE | $465,105 | Grant | Trans-NIH Recovery Act Research Support: There is a pressing need to improve early detection of ASD so that families can access intensive, appropriate intervention services as early as possible. However, studies indicate that important racial and ethnic disparities exist in the identification an | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $321,300 | Grant | Trans-NIH Recovery Act Research Support: There are many research questions about effects of naturally-occuring behaviors (e.g. dieting) on overweight and obesity for which a randomized controlled trial would be untenable. For these we must rely on observational studies, and causal inference with | Health and Human Services, Department of / National Institutes of Health | 7/19/2009 |
| UNIVERSITY OF MISSOURI SYSTEM | $400,758 | Grant | Trans-NIH Recovery Act Research Support: Maintaining homeostatic control of glucose levels prevents individuals from developing type 2diabetes (T2D). We recently observed a progressive increase in the daily insulin response among healthy individuals consuming a frequent meal pattern (6-meals in | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF WASHINGTON | $464,427 | Grant | Trans-NIH Recovery Act Research Support: Cross-relaxation imaging (CRI) is a new quantitative method of magnetic resonance imaging (MRI), which allows the measurement and in vivo mapping of two key parameters determining nuclear magnetic interactions between water and macromolecules in tissues - | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF LOUISVILLE | $406,131 | Grant | Trans-NIH Recovery Act Research Support: Inorganic arsenic is a natural drinking water contaminant and a known hepatotoxin. However, the exposure levels of arsenic required to cause overt liver damage may be higher than found in the US water supply. In preliminary studies, it was shown that chro | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| WAYNE STATE UNIVERSITY (INC) | $418,000 | Grant | Trans-NIH Recovery Act Research Support: The development of breast cancer is a consequence of genetic risks and environmental exposures. Polychlorinated biphenyls (PCBs) are environmental contaminants that, despite their banned use, represent ongoing threats to human due to their persistence in | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $433,072 | Grant | Trans-NIH Recovery Act Research Support: Normal thyroid function in pregnant women is essential to brain development in their children. Recent data suggests that even in asymptomatic women with subclinical hypothyroidism, intelligence of their offspring is affected. The Maternal-Fetal Medicine U | Health and Human Services, Department of / National Institutes of Health | 8/09/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $433,732 | Grant | Trans-NIH Recovery Act Research Support: Silica is the most abundant mineral in the earth's crust account for prevalent exposure to respirable silicates in many occupations in both affluent and developing nations. Besides smoking, this is the major preventable cause of chronic obstructive pulmon | Health and Human Services, Department of / National Institutes of Health | 5/19/2009 |
| PARKINSON'S INSTITUTE | $248,630 | Grant | Trans-NIH Recovery Act Research Support: Aim 1: Test the hypothesis that human LRRK2 mutant and overexpressing mice are more vulnerable to nigrostriatal toxicity induced by environmental exposure and/or aging. In this aim, we will test the interactive effects of gene alteration, toxicant expos | Health and Human Services, Department of / National Institutes of Health | 5/19/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $434,930 | Grant | Trans-NIH Recovery Act Research Support: Oxidative stress has long been known to be an important trigger for neoplastic development. The importance of oxidative stress in carcinogenesis is seen in the ability of chemical and environmental tumor promoters to induce the production of reactive oxyg | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| ST. JUDE CHILDREN'S RESEARCH HOSPITAL | $462,000 | Grant | Trans-NIH Recovery Act Research Support: The long-term objectives of this proposal are to determine the magnitude of PGRMC1's effect on CYP3A4 activity and if this effect is substrate specific. PGRMC1 is a hemoprotein with a cytochrome b5-like domain. PGRMC1 enhances CYP activity in yeast and in | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $446,875 | Grant | Trans-NIH Recovery Act Research Support: The source of abnormal outflow resistance in primary open angle glaucoma (POAG), a leading cause of blindness, has yet to be identified. We have found that acute elevation of intraocular pressure (IOP) in normal bovine and human eyes causes a decrease in | Health and Human Services, Department of / National Institutes of Health | 7/22/2009 |
| THE VANDERBILT UNIVERSITY | $426,463 | Grant | Trans-NIH Recovery Act Research Support: The pioneering of laser surgery and ocular coherence tomography by eye researchers has had a tremendous global health impact upon the current ability to diagnose, understand, treat, and monitor multiple eye diseases. The potential of combining these two p | Health and Human Services, Department of / National Institutes of Health | 9/14/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $418,662 | Grant | Trans-NIH Recovery Act Research Support: The PLAAY intervention seeks to train parents to provide racial coping knowledge and emotionally supportive coaching to Black youth who often retaliate when stressed, feeling incompetent in classrooms or appearing weak in interpersonal conflicts on the pl | Health and Human Services, Department of / National Institutes of Health | 5/27/2009 |
| REHABILITATION INSTITUTE OF CHICAGO | $417,242 | Grant | Trans-NIH Recovery Act Research Support: The goal of this proposed research is to improve the efficacy of body weight supported treadmill training (BWSTT) in people post-stroke using a novel robotic therapy that applies forces to the paralyzed leg during the swing phase of gait. Impaired mobilit | Health and Human Services, Department of / National Institutes of Health | 5/11/2009 |
| SOUTH CAROLINA RESEARCH FOUNDATION | $402,394 | Grant | Trans-NIH Recovery Act Research Support: MODELING SPATIAL AND FAMILY FACTORS IN THE TRANSMISSION OF WEALTH Specific Aims Our goal is to specify conditions under which men were able to accumulate wealth between 1850 and 1870 in a native born US population of related individuals. To do this, we wi | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $443,232 | Grant | Trans-NIH Recovery Act Research Support: Infertility is a major health problem in the U.S. It affects approximately 4 million reproductive age women, almost 60,000 of whom undergo assisted reproductive technology (ART) procedures each year. ART currently results in over 35,000 U.S. live births a | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $222,750 | Grant | Trans-NIH Recovery Act Research Support: Spinal muscular atrophy (SMA) is the leading genetic cause of infantile death and occurs in 1:6,000 to 1:10,000 live births. SMA is caused by a homozygous loss of the survival motor neuron-1 (SMN) gene leading to the progressive loss of alpha-motor neuron | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE INC | $228,218 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of proposed research is to understand the physiological role of zinc finger protein ZPR1 complexes in cell growth and development. ZPR1 interacts with survival motor neuron (SMN) and eukaryotic translation elongation factor 1A (eEF1A) p | Health and Human Services, Department of / National Institutes of Health | 5/04/2009 |
| CHILDRENS HOSPITAL OF PHILADELPHIA | $465,023 | Grant | Trans-NIH Recovery Act Research Support: An unfortunate consequence of the treatments currently used to treat pediatric cancers is infertility. An important issue to consider is whether a child's fertility status later in life is likely to be impacted by his treatment. Ideally, this should occu | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $423,036 | Grant | Trans-NIH Recovery Act Research Support: Exposure of men to gonadotoxic cancer therapeutic agents can severely impair spermatogenesis. Many of the radiotherapeutic and chemotherapeutic regimens may result in complete killing of the stem spermatogonia without a chance for endogenous restoration o | Health and Human Services, Department of / National Institutes of Health | 9/02/2009 |
| UNIVERSITY OF ALABAMA AT BIRMINGHAM | $401,855 | Grant | Trans-NIH Recovery Act Research Support: This program will use several recent findings from clinical research to determine whether progressive multiple sclerosis (MS) significantly responds to a specific form of controlled physical therapy by increasing (1) real-world functional abilities for ex | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $617,445 | Grant | Trans-NIH Recovery Act Research Support: It has become clear that a proportion of the genetic risk for autism spectrum disorders (ASD) is attributable to such genomic events, and the culmination of numerous ongoing studies of common polymorphisms and rare anomalies will likely provide important | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF RHODE ISLAND | $434,188 | Grant | Trans-NIH Recovery Act Research Support: The proposed project is designed to develop and test the feasibility of an innovative, individualized intervention to increase blood donation rates among African Americans. Red blood cell transfusions are used to treat and to prevent some of the complicat | Health and Human Services, Department of / National Institutes of Health | 5/18/2009 |
| GEORGIA HEALTH SCIENCES UNIVERSITY RESEARCH INSTITUTE, INC. | $404,250 | Grant | Trans-NIH Recovery Act Research Support: The prevalence of hypertension and cardiovascular disease has increased in recent decades in parallel with increasing obesity. This project explores the hypothesis that a person's physical activity levels influence expression of receptors for leptin, a ho | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| UNIVERSITY OF UTAH, THE | $366,150 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Ion channels of excitable membranes are responsible for synchronizing the firing and recovery of excitable cells such as cardiac myocytes. It is well established that heterogeneities and loss of ion channel function is | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $459,156 | Grant | Trans-NIH Recovery Act Research Support: Many patients who survive the first few days of critical illness do so with multiple residual organ failures. These patients become dependent on mechanical ventilation and other organ support systems initiated in the ICU. In order to help clarify prognosi | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF ILLINOIS | $409,432 | Grant | Trans-NIH Recovery Act Research Support: Hypertrophic growth of adult cardiac myocytes is a clinical manifestation of many cardiovascular disorders and is often a direct cause of heart failure. Occurring as a compensatory response to cardiac stress, it involves thickening of the heart muscle an | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $771,875 | Grant | Trans-NIH Recovery Act Research Support: Essential hypertension is a major public health concern due to its high prevalence and its role as a leading risk factor for leading causes of death and morbidity in the developed world - coronary artery disease, stroke, chronic renal disease and peripher | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| MISSOURI SYSTEM, UNIVERSITY OF | $219,972 | Grant | Trans-NIH Recovery Act Research Support: A decade ago when microarray was first invented, it was hailed as 'an array of hope' in Nature Genetics and has received a considerable amount of attention in biomedicine. Subsequently it has been called 'an array of problems' in Nature Review. An inheren | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $451,000 | Grant | Trans-NIH Recovery Act Research Support: Mechanisms of schizophrenia-like phenotypes in BACE 1 knockout mice. Schizophrenia is known to have a genetic basis but genome-wide association studies have revealed highly inconsistent findings. One gene that has been repeatedly linked to schizophrenia i | Health and Human Services, Department of / National Institutes of Health | 5/05/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $424,875 | Grant | Trans-NIH Recovery Act Research Support: Individuals with anorexia nervosa (AN) have aberrant feeding behavior, disturbances of emotionality and impulse control, and have high rates of relapse after weight restoration. There is no proven treatment that reverses symptoms. Although imaging studies | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| UNIVERSITY OF IOWA, THE | $297,121 | Grant | Trans-NIH Recovery Act Research Support: Animal studies show that prenatal maternal stress (PNMS) results in maternal glucocorticoids passing the placental barrier and disrupting fetal brain development, particularly the hypothalamic-pituitary-adrenal axis. This in turn influences pregnancy outc | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| UNIVERSITY OF UTAH, THE | $413,875 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The objective of this application is to improve measurement of the intensity and functional aspects of pain by developing a novel assessment method and demonstrating its feasibility in both acute and chronic pain patie | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $406,250 | Grant | Trans-NIH Recovery Act Research Support: In the last three years, the biomedical community has seen an explosion in the use of invasive and non- invasive brain neuromodulation methods to increase recovery of function after localized brain damage. Such techniques operate on the principle that neu | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $400,615 | Grant | Trans-NIH Recovery Act Research Support: This project is being supported with funds from the American Recovery and Reinvestment Act, which may involve a reduction in the research aims and scope. If necessary, a revised abstract will be posted soon and this notice removed. DESCRIPTION (provided | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| UNIVERSITY OF WASHINGTON | $306,755 | Grant | Trans-NIH Recovery Act Research Support: Neurologic and psychiatric disorders are important and growing causes of morbidity and mortality affecting up to 1 billion people and causing almost 7 million deaths world-wide. The WHO recently estimated that neurological disorders represent the highest | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| THE VANDERBILT UNIVERSITY | $307,910 | Grant | Trans-NIH Recovery Act Research Support: This two year NICHD-focused R21 Brain Disorders proposal seeks two years of funding to support development of a long-term, sustainable collaborative research relationship and program with the Vietnamese Academy of Social Sciences in Hanoi, Vietnam. The re | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| PACIFIC INSTITUTE FOR RESEARCH AND EVALUATION | $1,068,942 | Grant | Trans-NIH Recovery Act Research Support: This is a two-year pilot intervention project to plan and implement a community-based participatory research (CBPR) program aimed at reducing substance abuse and related issues among Cambodian American women in the East San Francisco Bay Area city of Oakl | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| THE VANDERBILT UNIVERSITY | $681,605 | Grant | Trans-NIH Recovery Act Research Support: As noted in the request for applications, a key aspect of heterogeneity in autism spectrum disorders (ASD) is a relatively high number of clinical interventions that are commonly provided but have limited or even no objective evidence to support implement | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF PUERTO RICO | $667,999 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION : We propose a randomized controlled trial to adapt, implement and evaluate an intervention to prevent HIV/STI in young heterosexual Latino couples. The intervention consists of five three-hour sessions held once a week. We will use a group fo | Health and Human Services, Department of / National Institutes of Health | 5/08/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $680,908 | Grant | Trans-NIH Recovery Act Research Support: This R34 pilot proposal, entitled !Intensive Brain Training in Early Onset Schizophrenia & Schizoaffective Disorder! is submitted in response to RFA-MH-09-020 Novel Interventions for Neurodevelopmental Disorders. The overarching goal of this pilot study i | Health and Human Services, Department of / National Institutes of Health | 6/17/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $77,540 | Grant | Trans-NIH Recovery Act Research Support: The role of the media analysis researcher is to study and describe the content and quality of news coverage. Unfortunately media analysis researchers typically use methods that are time consuming, subjective and produce data that is hard to replicate. The | Health and Human Services, Department of / National Institutes of Health | 9/19/2009 |
| WASHINGTON UNIVERSITY, THE | $50,362 | Grant | Trans-NIH Recovery Act Research Support: Although considerable progress has been made in increasing breast cancer screening rates, there remains a significant proportion of women ages 40 and older who have rarely or never had a mammogram. To date, behavioral interventions to increase mammography | Health and Human Services, Department of / National Institutes of Health | 9/19/2009 |
| TRIBOLOGICS | $284,758 | Grant | Trans-NIH Recovery Act Research Support: Injury is a well established risk factor in the pathogenesis of osteoarthritis (OA) as supported by several large longitudinal population studies. Patients with meniscal and ACL injuries in particular are at risk for early OA. Chondroprotection of the joi | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| ARCHIE MD INC. | $213,771 | Grant | Trans-NIH Recovery Act Research Support: Women face a variety of medical decisions during pregnancy and childbirth. While there are extensive educational resources for pregnant women, modern medicine presents decisions that many women are poorly equipped to make. Issues such as prenatal screenin | Health and Human Services, Department of / National Institutes of Health | 8/07/2009 |
| BETASTEM THERAPEUTICS INC | $326,697 | Grant | ARRA - Community Services Block Grant: The long term goal is to develop an efficient, safe clinical treatment for diabetic retinopathy using stem cells from the patient's bone marrow or blood that have been activated to repair damaged vessels in the eye. Diabetic retinopathy remains theleading | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $433,750 | Grant | Trans-NIH Recovery Act Research Support: Title: Host Factor Genetics and Susceptibility to Retroviral Infection. The award supports research into the underlying role of host genes in determining susceptibility to infection with AIDS viruses (HIV-1, HIV-2 and the related lentiviruses), in a tr | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY | $385,117 | Grant | Trans-NIH Recovery Act Research Support: Anopheline mosquitoes are the primary vectors of malaria, which is one of the deadliest and most costly infectious diseases in human history. The long term objective of this study is to develop an efficient and safe gene drive mechanism that will enable g | Health and Human Services, Department of / National Institutes of Health | 5/19/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $367,558 | Grant | Trans-NIH Recovery Act Research Support: ROLE OF YAPS IN Y. PESTIS PATHOGENESIS Background and Aims Yersinia pestis (Yp) is a Gram-negative bacterial human pathogen that is the causative agent of bubonic, pneumonic and septicemic plague. No vaccine is currently available for either form of plagu | Health and Human Services, Department of / National Institutes of Health | 5/15/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $166,924 | Grant | Trans-NIH Recovery Act Research Support: Enveloped viruses must fuse viral and cellular membranes to transfer the viral nucleic acid into the host cell and initiate the infectious cycle. These viruses have evolved dedicated fusion proteins that catalyze this energetically unfavorable process. Th | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $211,224 | Grant | Trans-NIH Recovery Act Research Support: The highly dynamic structure of chromatin governs access of many proteins to the underlying DNA, affecting the regulation of numerous fundamental biological processes. The generation of a competent immune system requires the assembly of antibody and T cel | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| UNIVERSITY OF CONNECTICUT | $956,194 | Grant | Trans-NIH Recovery Act Research Support: This application addresses the broad challenge area of (06) Enabling Technology and the specific challenge topic 06-OD(OBSSR)-101 Using new technologies to improve treatment adherence. Strict adherence to antiretroviral medications is necessary for people | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| WASHINGTON UNIVERSITY, THE | $819,999 | Grant | Trans-NIH Recovery Act Research Support: Evidence suggests that the pathology of Alzheimer's disease (AD) begins to accrue as many as 10-15 years prior to the earliest signs and symptoms of cognitive decline characteristic of AD. This period, during which pathology is developing but individuals | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| WASHINGTON UNIVERSITY, THE | $780,796 | Grant | Trans-NIH Recovery Act Research Support: Prospective memory (remembering to carry out an intention at an opportune time in the future) is especially important for older adults. Age-related PM failures can threaten independent living and, for health-related concerns, even be life threatening. The | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $920,335 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (09): Health Disparities and specific Challenge Topic, 09-AG-101: Geographic Disparities in Medicare Usage. The proposed project will describe geographic disparities in quality of care of back surgery and ex | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $994,460 | Grant | Trans-NIH Recovery Act Research Support: This challenge grant addresses the broad challenge area (03) 'Biomarker Discovery and Validation'. The challenge topic is 03-AI-101, entitled 'Identification, characterization and evaluation of novel pathogen or host targets that may lead to the developme | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| KAISER FOUNDATION HOSPITALS | $999,370 | Grant | Trans-NIH Recovery Act Research Support: This application responds to broad Challenge Area (05): Comparative Effectiveness Research (CER), and specific Challenge Topic 05-AR-101: Comparative Effectiveness of Biologics in Autoimmune Rheumatic and Skin Diseases, with emphasis on five diseases: rhe | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF MASSACHUSETTS | $968,410 | Grant | Trans-NIH Recovery Act Research Support: Translational Research: From Mechanisms of Influenza Trnasmission to Prevention | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| PORTLAND STATE UNIVERSITY | $987,502 | Grant | Trans-NIH Recovery Act Research Support: With regard to the annual toll of people killed, malaria remains one of the deadliest diseases in the world today, as it has been so for thousands of years. For each of the 1 million people killed each year there are hundreds that are severely sickened by | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| NEW YORK UNIVERSITY (INC) | $959,125 | Grant | Trans-NIH Recovery Act Research Support: Challenge Area: Translational Science Specific Challenge Topic 15-AI-101: Explore the earliest events in HIV infection and use this information to develop new interventions for preventing and treating HIV infection. Despite significant progress in HIV res | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $988,616 | Grant | Trans-NIH Recovery Act Research Support: We have discovered drugs capable of inducing skin melanin production without producing DNA damage, like UV radiation. This approach protects against UV induced skin cancers in mice. Here, we will evaluate and identify drugs capable of darkening human skin | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $999,956 | Grant | Trans-NIH Recovery Act Research Support: We propose to build upon our experience in meta-analysis, large-scale epidemiology, and cost-effectiveness research in rheumatoid arthritis (RA) using three large RA registries, a systematic literature review, and computerized simulation modeling to study | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $987,770 | Grant | Trans-NIH Recovery Act Research Support: This proposal is for a Rare Cancer Genetics Registry (RCGR). The proposal is being submitted for Challenge Area: 07: Enhancing Clinical Trials and specific Challenge Topic: Rare Disease Genetic Patient Registry: 07-OD(ORDR)-102. We will develop a registry | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| CANCER PREVENTION INSTITUTE OF CALIFORNIA | $999,575 | Grant | Trans-NIH Recovery Act Research Support: This community mapping project is designed to address a major gap in health prevention for minority communities by bringing together researchers and members of an underserved racial/ethnic community to produce a collaboratively developed profile of neighb | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF ROCHESTER | $999,997 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (04) Clinical Research, and specific Challenge Topic, 04-ES-102: Investigating gene x environment interaction using controlled human exposures. Increases in ambient particulate matter (PM) are associated wit | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $996,394 | Grant | Trans-NIH Recovery Act Research Support: Overall Purpose/Goal: Extreme heat events (EHE) remain the leading cause of weather-related morbidity and mortality in the United States. Goal: To develop for the State of California an analytic framework to: (1) advance knowledge of the relations between | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| EMORY UNIVERSITY | $852,500 | Grant | Trans-NIH Recovery Act Research Support: Characterization of the Transcriptome in an Emerging Model for Social Behavior This application addresses broad Challenge Area (01): Behavior, Behavioral Change, and Prevention and specific Challenge Topic, 01-GM-102: Model organisms for social behavior s | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $747,166 | Grant | Trans-NIH Recovery Act Research Support: This proposal addresses Broad Challenge Area (06) Enabling Technologies and Specific Challenge Topic 06-GM-109 Green chemistry and engineering for drug discovery, development, and production. Development of chemical methodologies and tools to promote gree | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $999,892 | Grant | Trans-NIH Recovery Act Research Support: With advances in our understanding of the underlying molecular mechanism of diseases such as cancer, new genetically encoded technologies that support the targeted reprogramming of cellular fate and function in humans are critical to the development of ne | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $999,445 | Grant | Trans-NIH Recovery Act Research Support: Award Title: Real-Time Imaging of Dynamic Biological Processes at Nanometer Spatial Resolution Award Description: The focus of this project is the development and optimization of a novel approach for high-resolution direct imaging of biological processes | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| PURDUE UNIVERSITY | $973,748 | Grant | Trans-NIH Recovery Act Research Support: An interdisciplinary team of experimental biologists (Drs. Tyrrell Conway, Barry L. Wanner, and Daoguo Zhou), computational biologists (Drs. Michael R. Gribskov, Daisuke Kihara, and David W. Ussery), and mathematical modelers (Drs. Julio Collado-Vides and | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: The advent of new stem cell approaches to cure disease and repair tissue damage is one of the most exciting developments in recent science. Some of the most exciting stem cell technology rests with the ability to reprogram nuclei. The oocyte is uniquely | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $998,119 | Grant | Trans-NIH Recovery Act Research Support: This application addresses Broad Challenge Area (12) Science, Technology, Engineering and Mathematics Education and specific challenge area 12-OD-101, Efficacy of educational approaches toward promoting STEM competencies. The title of the proposal is Impr | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| GREENWOOD GENETIC CENTER INC. | $861,006 | Grant | Trans-NIH Recovery Act Research Support: PROMOTING GENETIC LITERACY IN STUDENTS AND TEACHERS: THE EFFECTIVENESS OF NON-CLASSROOM INSTRUCTIONAL STRATEGIES AND SETTINGS | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $998,462 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (03) Biomarker Discovery and Validation and specific Challenge Topic, 03-HL-101: Identify and Validate Clinically Relevant, Quantifiable Biomarkers of Diagnostic and Therapeutic Responses to Blood, Vascular, | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $924,643 | Grant | Trans-NIH Recovery Act Research Support: Idiopathic (primary) pulmonary artery hypertension in children or adults (IPAH) is a progressive and fatal disease characterized by sustained elevations of pulmonary artery pressure of unknown etiology. Vasodilators are the mainstay of therapy, however 20 | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| DUKE UNIVERSITY | $847,352 | Grant | Trans-NIH Recovery Act Research Support: This application addresses Challenge Area (04) Clinical Research and specific Challenge Topic 04-HL-114: Using existing datasets to plan effectiveness trials in pediatric cardiology. Most of the treatments used in children undergoing congenital heart surg | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $993,625 | Grant | Trans-NIH Recovery Act Research Support: This work is related to lung disease and in particular molecular markers that will assist in our understanding of the mechanisms that promote airway inflammation, fibrosis, and COPD. We are generating monoclonal antibodies to large numbers of lung protein | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| NORTHEAST OHIO MEDICAL UNIVERSITY | $998,178 | Grant | Trans-NIH Recovery Act Research Support: This grant proposes to expand on practical aspects of stem cell therapies by determining which type of stem cell best promotes coronary collateral growth in the heart, the conditions in the heart that are conducive to promote collateral growth, and finall | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $999,759 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (05) Comparative Effectiveness Research and specific Challenge Topic, 05-MD-105: Health Literacy. Limited health literacy affects over 90 million Americans, and is strongly associated with poor health. While | Health and Human Services, Department of / National Institutes of Health | 9/20/2009 |
| EMORY UNIVERSITY | $998,982 | Grant | Trans-NIH Recovery Act Research Support: Men who have sex with men (MSM) are the most heavily impacted risk group in the US HIV epidemic, both in absolute numbers and in infection rates. Within the US MSM HIV epidemic, black and Hispanic MSM are disproportionately affected compared to other raci | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| MEDICAL UNIVERSITY OF SOUTH CAROLINA | $998,153 | Grant | Trans-NIH Recovery Act Research Support: This project addresses broad Challenge Area (09) Health Disparities and specific Challenge Topic, 09-MD-101: Creating Transformational Approaches to Address Rural Health Disparities. A quasi-experimental clinical trial will test the effectiveness of the | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $939,585 | Grant | Trans-NIH Recovery Act Research Support: We propose to conduct a comparative effectiveness analysis and cost effectiveness analysis to investigate the benefit of health insurance reform on addressing cancer health disparities. The social determinants of cancer health disparities have been descri | Health and Human Services, Department of / National Institutes of Health | 9/20/2009 |
| CAMBRIDGE PUBLIC HEALTH COMMISSION | $999,892 | Grant | Trans-NIH Recovery Act Research Support: The proposed research is designed to improve the effectiveness of identification, referral and screening for mental health disorders potentially associated with ethnic/racial disparities in adolescent receipt of mental health care. Using data from the Nat | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF MIAMI | $999,221 | Grant | Trans-NIH Recovery Act Research Support: There is emerging evidence to suggest that culturally informed and tailored/flexible intervention can lead to enhanced treatment effects with minority youth (Griner & Smith, 2006). CIFFTA was designed to address unique stressors faced by minority youth i | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $996,371 | Grant | Trans-NIH Recovery Act Research Support: This proposal represents a move from genomics to biology designed to identify the patterns of gene expression induced by disease-associated mutations and help frame our understanding and elucidate the structure of the still elusive genetic interactions un | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $994,788 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (03) Biomarker Discovery and Validation and specific Challenge Topic 03-MH-101 Biomarkers in mental disorders. Post-traumatic stress disorder (PTSD) is one of the more co | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $951,326 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (03): Biomarker Discovery and Validation and specific Challenge Topic, 03-MH-101: Biomarkers in mental disorders. While Major Depressive Disorder (MDD) is prevalent and disabling, compelling recent data from | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO | $723,678 | Grant | Trans-NIH Recovery Act Research Support: Analyses of Registration Bipolar Prophylaxis Trials to Develop New Study Designs This application addresses Challenge Area (05) Comparative Effectiveness Research (CER) and specific Challenge Topic 05-MH-102 Cost Effectiveness of Mental Health Interventio | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $999,953 | Grant | Trans-NIH Recovery Act Research Support: Neonatal Brain Segmentation - ARRA The goal of this project is to develop fully automatic, accurate neonatal brain segmentation methods, to facilitate understanding of normal brain development and also future study of neurodevelopmental disorders in the | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| WASHINGTON UNIVERSITY, THE | $999,962 | Grant | Trans-NIH Recovery Act Research Support: This application addresses Broad Challenge Area (15): Translational Science and Specific Challenge Topic, 15-MH-109: Prefrontal cortex regulation of higher brain function and complex behaviors. The goal of this project is to understand the neural mechanis | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $966,538 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (15): Translational Science and Specific Challenge Topic 15-NR-101: NIH Partners in Research Program: Pathways for Translational Research. Autism Spectrum Disorders (ASD) represent a group of neurodevelopmen | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $1,311,987 | Grant | Trans-NIH Recovery Act Research Support: The overall objective of the project is to complete preclinical development of a formulated caspase inhibitor for the intraarticular treatment of patients with posttraumatic arthritis and the prevention of chronic osteoarthritis. The first milestone of t | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF MISSOURI SYSTEM | $1,077,285 | Grant | Trans-NIH Recovery Act Research Support: Musculoskeletal conditions, such as sarcopenia and osteoporosis are serious health threats among the elderly and are the major causes for debilitating injuries, loss of independence, and reduced quality of life, accounting for premature death in the elder | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $830,902 | Grant | Trans-NIH Recovery Act Research Support: The genetic components of age-related disorders are of intense interest, and genome wide association studies (GWAS) are an important tool in identifying chromosomal loci that are associated with disease. Two of the major and interlinked challenges for suc | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| KAISER FOUNDATION HOSPITALS | $4,971,981 | Grant | Trans-NIH Recovery Act Research Support: Atrial fibrillation is the most common clinically significant arrhythmia in adults and one of the most potent risk factors for ischemic stroke and other systemic thromboembolism. It currently affects millions of Americans and its prevalence is expected to | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| SOUTH CAROLINA RESEARCH FOUNDATION | $4,828,009 | Grant | Trans-NIH Recovery Act Research Support: AN OPEN SOURCE RESEARCH PERMISSIONS FRAMEWORK FOR SOUTH CAROLINA PROJECT NARRATIVE The current Grand Opportunity grant will allow the SC Center of Economic Excellence in Healthcare Quality (CHQ) to accelerate its planned clinical and translational researc | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF MIAMI | $1,652,959 | Grant | Trans-NIH Recovery Act Research Support: Increasing minority representation in clinical trials is a priority for the National Institutes of Health. Without adequate representation of all racial/ethnic groups, the results from randomized clinical trials, which are the gold standard for evaluation | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF PITTSBURGH THE | $1,299,870 | Grant | Trans-NIH Recovery Act Research Support: Dengue virus (DENV) infection of humans has steadily increased in importance as an emerging infectious disease, and the development of protective vaccines to DENV disease has been impeded by a lack of understanding of virus-specific immune responses and t | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF ILLINOIS | $929,298 | Grant | Trans-NIH Recovery Act Research Support: This application will study an innovative approach to implementing mental health services in child welfare settings to reduce foster childrenG??s behavior problems and improve school outcomes. This work will address two critical needs in child mental hea | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $999,868 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (03): Biomarker Discovery and Validation, 03-MH- 101 Biomarkers in mental disorders. The research proposed continues investigation of a new treatment-response biomarker (antipsychotic-biomarker) identified i | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| TOTAL CHILD HEALTH, INC. | $998,780 | Grant | Trans-NIH Recovery Act Research Support: The study's purpose is a cost-effectiveness study taking advantage of data from a large cohort derived from universal school screening for symptoms of ADHD collected by a web-based decision support system. Said system, called CHADIS, collects data from pa | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $749,340 | Grant | Trans-NIH Recovery Act Research Support: Neuropathic pain remains intractable despite treatment with currently available therapeutic agents. Therefore, it is necessary to identify novel pharmacotherapeutics that can effectively attenuate neuropathic pain. Activation of microglia and astrocytes ( | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF PITTSBURGH THE | $876,706 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of the project is to validate specific protein biomarkers for amyotrophic lateral sclerosis (ALS). ALS is a fatal motor neuron disease that can strike adults of any age, yet we know little about its causes and cannot rapidly diagnose | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $949,060 | Grant | Trans-NIH Recovery Act Research Support: This application addresses broad Challenge Area (15): Translational Science, and Specific Challenge Topic 15-NS-104: Early Stage Therapy Development. We propose to develop and evaluate small-molecule orexin receptor agonists as preclinical leads for the t | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF UTAH, THE | $923,041 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (15): Translational Science and specific Challenge Topic, 15- NS-104: Early-Stage Therapy Development. The major goal of the proposed work is to develop novel technical a | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| EMORY UNIVERSITY | $1,000,000 | Grant | Trans-NIH Recovery Act Research Support: Award Title: Comprehensive mutation detection for Neuromuscular disorders: Bringing new technologies to clinic Purpose:We propose to design a set of microarray-based tools that will enable the high- throughput comprehensive identification of genetic varia | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| OAKLAND UNIVERSITY | $265,055 | Grant | Trans-NIH Recovery Act Research Support: Science, Technology, Engineering and Mathematics Education (STEM). Specific Challenge Topic 12-OD-104, innovative approaches to STEM education. Our goal is to develop an undergraduate biology laboratory module that is superior to materials that are curren | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| RUSH UNIVERSITY MEDICAL CENTER | $998,322 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of the proposed project is to explore the role of the brain histone epigenome in modulating the effect of life experiences on cognitive decline and dementia. In prior work, we found that while cognitive decline in old age often results fr | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $472,841 | Grant | Trans-NIH Recovery Act Research Support: The overall objective of this application is to find out which non-protein-coding RNAs are differentially expressed in Alzheimer's disease patients. We will create an inventory of nonprotein-coding RNAs by performing extensive sequencing of RNA samples fr | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF PITTSBURGH THE | $1,730,845 | Grant | Trans-NIH Recovery Act Research Support: The goal of this proposal is to perform the integrated multi-disciplinary large animal studies needed to advance clinical treatment and assessment of articular cartilage injury and degeneration in the United States. Microfracture, a simple and minimally i | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| THE VANDERBILT UNIVERSITY | $2,661,005 | Grant | Trans-NIH Recovery Act Research Support: Drugs of abuse are metabolized by the cells of the body including macrophages and leukocytes. Macrophages are primarily responsible for the detection, phagocytosis and digestion of toxins in the bloodstream and peripheral tissues. Normal cellular metabol | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CHICAGO, THE | $770,000 | Grant | Trans-NIH Recovery Act Research Support: This application addresses Recovery Act Limited Competition: Research and Research Infrastructure 'Grand Opportunities' (GO) (RC2): NIDCR guidelines, RFA-OD-09-004: Area of Scientific Priority 4) Detection of Oral Premalignant and Malignant Lesions. This | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $6,148,731 | Grant | Trans-NIH Recovery Act Research Support: The burden of disease attributable to obesity is enormous. Obesity is highly prevalent and associated with more than 60 metabolic, inflammatory, degenerative, cognitive, and neoplastic disorders. Broadly effective preventive and therapeutic strategies hav | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| WAKE FOREST UNIVERSITY | $2,033,637 | Grant | Trans-NIH Recovery Act Research Support: Medical imaging is a critical and expensive component of health care with a cost of $100 billion or $350 per person per year. Health information technology (HIT) is proposed as a means to reduce costs and improve health through more efficient and coordina | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| MICHIGAN STATE UNIVERSITY | $984,612 | Grant | Trans-NIH Recovery Act Research Support: Engineered nanomaterials (ENM) have unique properties that can cause adverse health effects. Due to their small size and potential for airborne dispersion, inhalation exposure to ENM might contribute to the increased incidence and/or exacerbation of aller | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF MISSOURI SYSTEM | $900,000 | Grant | Trans-NIH Recovery Act Research Support: Obstruction voiding disorder (OVD) and high-grade prostatic intraepithelial neoplasia (HGPIN) are common diseases of aging men. HGPIN is a precancerous lesion that usually leads to aggressive therapy upon detection. There has long been speculation that th | Health and Human Services, Department of / National Institutes of Health | 9/27/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $1,921,419 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Breast cancer incidence has increased substantially during the last three decades, coinciding with the introduction of hormone mimics into the environment. It has been postulated that developmental exposure to xenoestr | Health and Human Services, Department of / National Institutes of Health | 9/27/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $2,000,000 | Grant | Trans-NIH Recovery Act Research Support: Transcription factors (TF) have a crucial role in controlling gene expression, and exploring their molecular targets, binding partners and mode of regulation is essential to understand any plant biological process. Arabidopsis offers some unique advantage | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| AMERICAN SOCIETY FOR CELL BIOLOGY, THE | $2,490,729 | Grant | Trans-NIH Recovery Act Research Support: Development of a comprehensive, easily accessible public resource database of images, videos, and animations of cells from a variety of organisms, including both cell architecture and intracellular functionalities, as well as stimulate the economy through | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| LELAND STANFORD JUNIOR UNIVERSITY, THE | $2,774,729 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The overall goal of this proposal is to develop a strategy towards clinical resequencing of the human genome which we define as the application of human genome resequencing to large clinical populations for disease gen | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $1,500,000 | Grant | Trans-NIH Recovery Act Research Support: Every person differs in his or her response to pathogens and in the likelihood that they will suffer from complex diseases such as cancer, heart disease or diabetes. Individual susceptibility to disease is determined in part by genetics, and we can map wi | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $1,600,000 | Grant | Trans-NIH Recovery Act Research Support: Generating and Managing Large Scale Proteogenomic Data for ENCODE Cell Lines -The first human genome sequence was published in 2001, yet as of now, eight years later, major questions remain, such as how many genes are encoded by the genome, and of those g | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF MARYLAND | $1,364,612 | Grant | Trans-NIH Recovery Act Research Support: Increasing amounts of sequence data are being generated in multiple biomedical research disciplines, particularly through the application of next-generation sequencing technologies to the genomic analysis of humans and their associated microbiome. However | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $2,789,724 | Grant | Trans-NIH Recovery Act Research Support: The aims of the ENCODE (Encyclopedia of DNA Elements) and modENCODE (model organism ENCODE) projects are to apply high-throughput, cost-efficient approaches to generate a catalog of functional elements in the human, worm, and fly genomes, which will serve | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF WASHINGTON | $1,350,000 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to produce comprehensive, high-definition maps of mouse regulatory DNA marked by DNaseI hypersensitive sites to parallel the human catalogue currently under production by the ENCODE Project. Digital DNaseI technology enables e | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $1,288,171 | Grant | Trans-NIH Recovery Act Research Support: The mammalian eye serves both visual and non-image-forming functions. Until recently, clinical and research attention has focused on visual function. However, new work has begun to characterize the anatomy and physiology of the non-image-forming responses | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $2,716,079 | Grant | Trans-NIH Recovery Act Research Support: The goal of this project is to employ embryonic stem (ES) cell and induced pluripotent stem (iPS) cell systems to define the genetic and epigenetic programs of the earliest stages of human development, and to decipher whether identifiable components of th | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | $8,346,809 | Grant | Trans-NIH Recovery Act Research Support: Asthma affects over 17 million people in the United States, and is a significant cause of morbidity. Development of novel therapies to reduce asthma burden is a major priority of the scientific community, yet such studies are often hampered by the limited | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| BOSTON MEDICAL CENTER CORPORATION | $3,559,944 | Grant | Trans-NIH Recovery Act Research Support: To develop an extensive, de-identified, easily accessible database including information about child and adult residents using clinical data from: (1) New England's largest safety net hospital, Boston Medical Center, and its affiliated community health ce | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| KAISER FOUNDATION HOSPITALS | $7,217,106 | Grant | Trans-NIH Recovery Act Research Support: This project will establish a surveillance system for cardiovascular disease in approximately 11 million health maintenance organization (HMO) members. The surveillance system will be initially established for coronary heart disease (CHD), heart failure ( | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | $1,576,840 | Grant | Trans-NIH Recovery Act Research Support: The large ongoing NIH COPDGene® trial is a genome wide association study designed to elucidate the genetic basis of chronic obstructive pulmonary disease (COPD). This study also provides a unique opportunity to rapidly develop plasma biomarkers for C | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF WASHINGTON | $4,676,664 | Grant | Trans-NIH Recovery Act Research Support: Specific Aims: Acute Lung Injury (ALI) is a common complication of sepsis and trauma and is associated with mortality of over 20%. Candidate gene studies suggest a role for common genetic variation in determining host susceptibility to ALI in critically | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF PITTSBURGH THE | $501,237 | Grant | Trans-NIH Recovery Act Research Support: Schizophrenia is a common, devastating illness that can not be treated adequately. Hence it is important to understand its causation. Schizophrenia is heritable, providing an important clue about its origins. Ongoing studies show that variation in DNA | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $66,172 | Grant | Trans-NIH Recovery Act Research Support: Schizophrenia is a common profoundly disabling disorder that carries a heavy burden for patients and families and is the subject of intensive genetic studies. The study of epigenetic variation is an essential complement to conventional genetic disease stu | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | $1,838,410 | Grant | Trans-NIH Recovery Act Research Support: Bipolar disorder (BPD) is a neuropsychiatric condition defined by a lifetime of relapsing & remitting manic & depressive episodes. This mood disorder has been shown to have strong genetic linkage with familial predisposition. A major impediment to proper | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $8,920,456 | Grant | Trans-NIH Recovery Act Research Support: We will create a transcriptional atlas of the developing human brain, including novel transcripts and regional expression patterns that can be followed up subsequently with histochemical mapping for cellular specificity. These data will be made available | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $85,925 | Grant | Trans-NIH Recovery Act Research Support: The proposed project is to obtain equipment that utilizes the most modern technological advances in order to update our laser capture microdissection (LCM) equipment. LCM is a technology for isolating pure populations of cells from tissue sections. Cells | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| TRUSTEES OF TUFTS COLLEGE INC | $342,645 | Grant | Trans-NIH Recovery Act Research Support: This grant provided funds for a VisualSonics Vevo770 Imaging System to support research being carried out at Tufts University School of Medicine (TUSM) and the Tufts Medical Center (TMC) in Boston. The instrument is being used by 12 well funded NIH inves | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $2,000,000 | Grant | Trans-NIH Recovery Act Research Support: Funds are requested for purchase of a state-of-the-art 300 keV liquid helium Transmission Electron Cryo-Microscope with a Field Emission Gun. To leverage the funds provided by this NIH program, approximately 40% of the funds for this microscope will be de | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $2,000,000 | Grant | Trans-NIH Recovery Act Research Support: Cardiovascular molecular imaging is a rapidly emerging area offering considerable promise for the evaluation of patients with heart and vascular disease. While proof of concept studies using novel imaging agents and micro PET have been conducted in mouse | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $191,610 | Grant | Trans-NIH Recovery Act Research Support: This research project was originally submitted as an Instrumentation Grant in response to PAR-08-036. The National Center for Research Resources awarded this project under the American Recovery and Reinvestment Act of 2009 (ARRA). The instrument, a COPAS | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $341,052 | Grant | Trans-NIH Recovery Act Research Support: Optical imaging is rapidly becoming one of the most versatile imaging modalities in biomedical research. The advantages of optical imaging compared to other imaging modalities include its non-ionizing low-energy radiation, high sensitivity for detecting o | Health and Human Services, Department of / National Institutes of Health | 4/28/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $458,778 | Grant | Trans-NIH Recovery Act Research Support: This application requests funds to purchase an Applied Biosystems MDS SCIEX 4000 QTRAP triple quadrupole mass spectrometer and an Agilent 1200 LC system needed for operation of the LC/MS/MS instrument. The instrument will be used in a new lipid analysis c | Health and Human Services, Department of / National Institutes of Health | 6/08/2009 |
| UNIVERSITY OF TEXAS AT SAN ANTONIO | $143,961 | Grant | Trans-NIH Recovery Act Research Support: Prospective memory is defined as remembering to perform an action in the future, such as remembering to give a friend a message or to make a doctor's appointment. The ability to perform prospective memory is essential for living independently as we age. | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| SMITHS DETECTION, INC. | $2,244,114 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The project will develop a decaplex assay to detect varieties of the Category C Priority Pathogen, influenza, listed in Table 1, within 30 minutes of taking a raw patient sample. The subtypes that are detected are all | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| SRI INTERNATIONAL | $1,837,524 | Grant | Trans-NIH Recovery Act Research Support: This grant has been designed around five major milestones that track with the three specific aims of the proposal. The overall goal of this program is to establish a validated series of compounds for lead optimization possessing activity against the gyras | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| IQUUM, INC. | $1,872,460 | Grant | Trans-NIH Recovery Act Research Support: Rapid Point of Care Diagnostics Assay for Pandemic Influenza. We propose to develop a Liat(tm) Pandemic Influenza Assay to enable the specific detection and differentiation of potential pandemic influenza in less than 25 minutes. We will also develop a | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| TRUSTEES OF BOSTON UNIVERSITY | $946,260 | Grant | Trans-NIH Recovery Act Research Support: The Centers for Disease Control and Prevention (CDC) and the National Institute of Allergy and Infectious Diseases (NIAID) have classified the filoviruses (Ebola, Marburg) and arenaviruses (e.g., Lassa, Junin, Machupo) that cause hemorrhagic fever (HF) as | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON | $1,212,096 | Grant | Trans-NIH Recovery Act Research Support: Flaviviruses populate the NIAID's Category A, B, and C lists of viruses. Vaccines are urgently needed for multiple flavivirus diseases, notably dengue and West Nile encephalitis. To develop more effective vaccines a comprehensive understanding of how flav | Health and Human Services, Department of / National Institutes of Health | 7/30/2009 |
| FRIENDS RESEARCH INSTITUTE, INC | $977,169 | Grant | Trans-NIH Recovery Act Research Support: With greater availability of evidence-based practices in the drug abuse field, specifically, for offender clients, it is crucial that we develop strategies that allow for the adoption, implementation and sustaining of aids to effective clinical practice. | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $770,000 | Grant | Trans-NIH Recovery Act Research Support: The Ability to Survive Arf-Mediated, Oncogenic Stress Defines PH+ B-ALL Acute Lymphoblastic Leukemia Initiating Cells. Philadelphia-chromosome (Ph+) B-acute lymphoblastic leukemia (B-ALL) patients have a poor prognosis, and more information about disease | Health and Human Services, Department of / National Institutes of Health | 7/29/2009 |
| WAYNE STATE UNIVERSITY (INC) | $1,002,772 | Grant | Trans-NIH Recovery Act Research Support: We propose a phase II trial that combines pimary oncologist's choice of chemotherapy (ChemoT) Consisting of 4 cycles or 4 months of followed by lymphodepletion with low dose fludarabine (Flu) and Cyclophosphamide (Cy) before giving multiple influsions of | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| THOMAS JEFFERSON UNIVERSITY | $622,356 | Grant | Trans-NIH Recovery Act Research Support: The BCR/ABL oncoproteins, the leukemia-specific gene products of the Philadelphia chromosome (Ph1) translocation, induce and maintain the leukemic phenotype through their deregulated tyrosine kinase activity; such activity is essential for recruitment and | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $698,046 | Grant | Trans-NIH Recovery Act Research Support: Structure and Function of Human Telomerase Telomerase is a large ribonucleoprotein complex responsible for replicating the G-rich strand of telomeres, the physical ends of chromosomes. It is critical for maintaining telomere length and preventing chromoso | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| YALE UNIVERSITY | $909,360 | Grant | Trans-NIH Recovery Act Research Support: The proposed experiments investigate signaling pathways linked to Slack potassium channels. Understanding these proteins will aid development of therapies for stroke, epilepsy and mental retardation. | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| YALE UNIVERSITY | $821,933 | Grant | Trans-NIH Recovery Act Research Support: As the genetic knowledge of epilepsy grows, primary prevention will soon be a realistic goal. Detailed study of a genetic animal model in which epilepsy can be prevented will provide proof-of-principle information to guide human treatment trials. In addit | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| MICROBIOTIX INC | $1,786,142 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The increasing prevalence of antibiotic-resistant strains of bacterial pathogens represents a major unmet medical need. Naturally occuring or intentionally engineered drug-resistance in biothreat agents is also a serio | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $675,244 | Grant | Trans-NIH Recovery Act Research Support: Human brucellosis, caused by Brucella spp., is one of the most widespread zoonotic diseases globally, with an estimated 500,000 new cases each year. An important pathogenic mechanism of this organism is it's ability to survive within the body's phagocytic | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $369,896 | Grant | Trans-NIH Recovery Act Research Support: Targeting CD8+ T Cells to Prevent B Cell Destruction The overarching goal of this proposal is to develop a method for blocking the autoreactive immune response directed at islet cell self components. Our approach is to delete antigen specific T cells us | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| BAYLOR COLLEGE OF MEDICINE | $767,500 | Grant | Trans-NIH Recovery Act Research Support: Fight quinolone-resistant and multidrug-resistant bacterial infections. Fluoroquinolones are the most frequently prescribed antimicrobial agents in the United States. Fluoroquinolone- and multidrug-resistant bacteria are emerging infectious disease agent | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF WASHINGTON | $780,000 | Grant | Trans-NIH Recovery Act Research Support: Productive differentiation of thymic epithelium is critical for thymopoiesis and the establishment of self-tolerance. However, the differentiation program that forms the thymic environment is not well understood. Studies proposed here are intended provid | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| ROCKEFELLER UNIVERSITY FACULTY AND STUDENTS CLUB INC, THE | $845,000 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of our research is to understand the interplay between virus and host, and to use this knowledge to gain better control over persistent viral infections. In this proposal we examine the interaction between the hepatitis C virus, HCV, an | Health and Human Services, Department of / National Institutes of Health | 7/23/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $766,119 | Grant | Trans-NIH Recovery Act Research Support: CD154 overexpression is a hallmark of Rheumatoid Arthritis(RA) and Systemic Lupus Erythematosus (SLE). The etiology of the overexpression of this critical immune molecule is not understood. Second,the targeting of CD154 by antibody based approaches is lim | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $553,202 | Grant | Trans-NIH Recovery Act Research Support: Lung cancer is an immense public health problem, and accounts for more years of life lost than the next three most common cause of cancer death combined. The goal of my laboratory is to understand mechanisms by which lung cancer tumors interact with their | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $352,172 | Grant | Trans-NIH Recovery Act Research Support: LIN-12/Notch proteins are receptors that mediate cell-cell interactions that specify cell fate during animal development. Notch activity plays a prominent role in many cell fate decisions in mammalian development. During adulthood, Notch activity continue | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| SCHEPENS EYE RESEARCH INSTITUTE, INC., THE | $1,224,824 | Grant | Trans-NIH Recovery Act Research Support: During this the first year of the stimulus grant we studied the therapeutic effect of in vivo injection of ACAID induced Tolerogenic APC on the clinical course of Experimental Autoimmune Uveitis ( EAU) in the C57/B6 mouse. We observed that the antigen | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| SALK INSTITUTE FOR BIOLOGICAL STUDIES,THE | $1,202,160 | Grant | Trans-NIH Recovery Act Research Support: One of the fundamental unanswered questions of sensory biology is how information provided by individual neurons within the brain is linked into a coherent whole. Individual visually responsive neurons only respond to stimulation over a limited portion of | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $2,270,042 | Grant | Trans-NIH Recovery Act Research Support: We propose to develop and improve a novel minimally-invasive retinal prosthesis design. The goal is to restore a limited but useful level of vision to patients blind with retinitis pigmentosa or macular degeneration. The implant will be driven wirelessly, | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| NORTHWESTERN UNIVERSITY | $794,834 | Grant | Trans-NIH Recovery Act Research Support: We propose to study the role of intermediate filaments (IF) in cell shape and motility. Our overarching hypothesis is that alterations in the assembly states and mechanical properties of cytoskeletal IF, specifically the type III IF composed of vimentin, | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $661,320 | Grant | Trans-NIH Recovery Act Research Support: N-linked glycoproteins and the pathways that produce them are integral in human health and disease since these glycoconjugates play fundamental roles in virtually all aspects of cellular function. Therefore, a detailed, molecular understanding of the pro | Health and Human Services, Department of / National Institutes of Health | 9/08/2009 |
| GEORGETOWN UNIVERSITY (THE) | $687,684 | Grant | Trans-NIH Recovery Act Research Support: This project examines the cellular mechanisms that promote initiation of DNA synthesis li DNA recombination. Such processes playa vital role in genetic exchange, double-strand break repair, and restart of replication forks. Bacteriophage Mu replicates its | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | $394,966 | Grant | Trans-NIH Recovery Act Research Support: This award is issued in response to Notice OD-09-060, Recovery Act Administrative Supplements Providing Summer Research Experiences for Students and Science Educators. DESCRIPTION (provided by applicant): FOA: NOT-OD-09-058 NIH Announces the Availability | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF MASSACHUSETTS | $328,543 | Grant | Trans-NIH Recovery Act Research Support: This award is a competitive revision request for grant RO1 DE 007444, 'Bone matrix and bone resorption,' under which we are investigating the osteoclast cell biology of a protein we discovered called plekhm1. Evidence indicates that plekhm1 is required fo | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| YALE UNIVERSITY | $34,781 | Grant | Trans-NIH Recovery Act Research Support: The pathologic proteolytic activation of digestive zymogens (primarily proteases such as chymotrypsinogen) within pancreatic acinar cells is a key step in initiating acute pancreatitis. Our laboratory examines extracellular factors and intracellular mecha | Health and Human Services, Department of / National Institutes of Health | 6/22/2009 |
| YALE UNIVERSITY | $97,030 | Grant | Trans-NIH Recovery Act Research Support: The pathologic proteolytic activation of digestive zymogens (primarily proteases such as chymotrypsinogen) within pancreatic acinar cells is a key step in initiating acute pancreatitis. Our laboratory examines extracellular factors and intracellular mecha | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $27,203 | Grant | Trans-NIH Recovery Act Research Support: Title: Stress-Induced Activation of Colonic Motor Function. Corticotropin-releasing factor (CRF) and urocortin (Ucn) 1 interact with two Gs coupled CRF1 and CRF2 receptors. Recently, new CRF-related peptides, Ucn 2 and Ucn 3, were discovered as selective | Health and Human Services, Department of / National Institutes of Health | 8/18/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $616,000 | Grant | Trans-NIH Recovery Act Research Support: During liver damage due to ischemia and reperfusion, the host pro-inflammatory effector memory, rather than na+?ve, CD4 T cells, promote local innate immune activation without de novo Ag-specific stimulation via the CD154-CD40 T cell costimulation pathway | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| JOSLIN DIABETES CENTER, INC. | $40,114 | Grant | Trans-NIH Recovery Act Research Support: Toll Receptor Activation of NF-kB in Insulin Resistance and T2D Studies in our laboratory are helping to unravel the complex processes that link obesity to its deleterious health consequences. We have found that the NF-kB transcription factor pathway is | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| YALE UNIVERSITY | $177,242 | Grant | Trans-NIH Recovery Act Research Support: Connective tissues, which include skin, fascia, ligament, tendon, blood vessel, etc, all rely upon extracellular matrix to provide the bulk of their mechanical properties. Collagenous extracellular matrix provides the tensile load bearing properties in al | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $160,301 | Grant | Trans-NIH Recovery Act Research Support: We are currently implementing the study as proposed in the supplement. We hired a full-time project coordinator for the study who officially started in October 2009. We have also participated in meetings with key stakeholders and religious organizations | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| KAISER FOUNDATION HOSPITALS | $92,772 | Grant | Trans-NIH Recovery Act Research Support: The administrative supplement to the SWIFT study will be used to hire part-time new staff, and augment existing part-time staff for the purpose of accelerating participant screening, recruitment, and data collection in three distinct geographic areas of t | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $197,182 | Grant | Trans-NIH Recovery Act Research Support: The studies described have great relevance to public health. Spermatogonial stem cells are at the foundation of the continual production throughout life of sperm in all males, including humans. Therefore, the function and normal activity of these stem c | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $30,509 | Grant | Trans-NIH Recovery Act Research Support: Our goal is to dissect the intercellular signaling mechanisms involved in the initial specification of mammary gland tissue, and those that regulate proliferation, branching morphogenesis and cell polarity at successive stages of mammary development. Brea | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF UTAH, THE | $168,856 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): In humans, deficiency of galactose-1-phosphate uridyltransferase (GALT) caused by mutations in the GALT gene leads to a potentially lethal disease, classic galactosemia. If galactose is not withdrawn from the diet of a | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| AGNES SCOTT COLLEGE, INC. | $23,931 | Grant | Trans-NIH Recovery Act Research Support: The long-term objectives of the proposed studies are to understand the role that early environment plays in the development of asymmetries in manual gestures and facial expressions and their relationship to different structures of the brain. In the propos | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF WASHINGTON | $155,876 | Grant | Trans-NIH Recovery Act Research Support: Research on the influence of gender on sexual behavior has tended to focus on women, leading to a relative lack of knowledge of the male side of gender, and the development and content of men's perspectives on their sexual behavior, prompting NICHD to iss | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| THE VANDERBILT UNIVERSITY | $12,257 | Grant | Trans-NIH Recovery Act Research Support: We propose to train, employ and mentor undergraduate students as Research Assistants in our NICHD-funded study, Addressing Health Literacy and Numeracy to Prevent Childhood Obesity (R01 - HD059794-01) -- a multi-site, controlled trial of a low-literacy, | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| THE VANDERBILT UNIVERSITY | $253,771 | Grant | Trans-NIH Recovery Act Research Support: We propose to train, employ and mentor undergraduate students as Research Assistants in our NICHD-funded study, 'Addressing Health Literacy and Numeracy to Prevent Childhood Obesity' (R01 - HD059794-01) -- a multi-site, controlled trial of a low-literacy | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| THE VANDERBILT UNIVERSITY | $503,328 | Grant | Trans-NIH Recovery Act Research Support: A two?year administrative supplement is requested, in order to pursue emerging opportunities that will accelerate science within the original scope of this project. The proposed investigations expand and advance work ongoing on the structural basis for mu | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF TEXAS M D ANDERSON | $1,331,493 | Grant | Trans-NIH Recovery Act Research Support: The proposed study continues a previously NCI-funded smoking cessation project that used motivational interviewing technique and health-status feedback (respiratory symptoms, lung function, and carbon monoxide in expired air) to induce and accelerate juni | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| HEALTH RESEARCH, INC. | $760,219 | Grant | Trans-NIH Recovery Act Research Support: Mutation of the retinoblastoma tumor suppressor gene (Rb1) causes the pediatric cancer retinoblastoma and contributes to most types of human cancer. Despite its central role in tumorigenesis, therapies designed to target this pathway have been slow to dev | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF IOWA, THE | $41,872 | Grant | Trans-NIH Recovery Act Research Support: This project continues the University of Iowa's multi-level International Training and Research Program in Occupational and Environmental Health (ITREOH) in an expanded number of developing democracies in Central and Eastern Europe. This program will buil | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $41,449 | Grant | Trans-NIH Recovery Act Research Support: AIDS International Training and Research Program-ARRA The purpose of the project is to conduct an analysis and develop a plan of action to upgrade the information technology at the UNC Project research and training site in Lilongwe, Malawi. Once the upg | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| AMERICAN DENTAL ASSOCIATION FOUNDATION | $75,000 | Grant | Trans-NIH Recovery Act Research Support: The intent of this proposal is to develop a dental informatics resource to support evidence-based dental care. Evidence-based dentistry is an approach of integrating the scientific basis for clinical care, using the best available scientific evidence, wit | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| FLORIDA A & M UNIVERSITY | $603,500 | Grant | Trans-NIH Recovery Act Research Support: This is a supplement to the Pharmaceutical Research Center at Florida A&M University (FAMU) in response The overall objective of this application is to increase the number of research scientists at FAMU and improve the research abilities of junior faculty | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| MEHARRY MEDICAL COLLEGE | $276,299 | Grant | Trans-NIH Recovery Act Research Support: Provide a summer undergraduate research experience for six minority undergraduate students in an area of health disparities. In addition, provide summer research opportunities for four high school science teachers from the Metropolitan Nashville Public Sc | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| RFCUNY - HUNTER COLLEGE | $299,440 | Grant | Trans-NIH Recovery Act Research Support: Research Centers in Minority Institutions Award: To assist predominantly minority institutions that offer the doctorate in the health professions and/or health-related sciences in strengthening and augmenting their human and physical resources for the con | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF MONTANA SYSTEM | $210,964 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this project are to better understand how the counseling process functioned within the parent study and to characterize college smokers' quit process. The proposed study takes advantage of a novel opportunity to explore counseling issues a | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| TRUSTEES OF DARTMOUTH COLLEGE | $227,780 | Grant | Trans-NIH Recovery Act Research Support: The long-term objective of this proposal is to test the hypothesis that factors, which promote the expression or activity of DN-p63 contribute to the preservation of self-renewal in basal epithelia, and factors that oppose the expression or activity of DN | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| UNIVERSITY OF SOUTH FLORIDA | $97,790 | Grant | Trans-NIH Recovery Act Research Support: Gamma or lymphotropic herpesviruses are characterized by their ability to cause a life-long latent infection in lymphoid cells. Epstein-Barr virus (EBV) and the Kaposi's Sarcoma Associated Herpesvirus (KSHV/HHV-8) are implicated as causative agents of mal | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| CORNELL UNIVERSITY, INC | $117,470 | Grant | Trans-NIH Recovery Act Research Support: Coordination of DMA replication and gene expression is central to the regulation of cell proliferation. A strategy for the coordination of these two processes is to engage the same regulators in both processes. Classical examples of such dual functional r | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $117,657 | Grant | Trans-NIH Recovery Act Research Support: Inhibition or lack of axon guidance affects neuronal cell motility and positional maintenance, resulting in the failure to regenerate neurona! connections after injury. Defective guidance is also associated with diseases ranging from Alzheimers to cancer. | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $68,339 | Grant | Trans-NIH Recovery Act Research Support: Carbonyl reductase activity accounts for a significant fraction of the metabolism of pharmacological agents extensively used in clinical practice such as the antipsychotic haloperidol and the anticancer anthracyclines doxorubicin and daunorubicin. In huma | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $237,599 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): Lung transplantation (LTX) reduces morbidity and mortality from respiratory failure, but acute and long-term outcomes remain poor. Primary lung graft failure occurs in up to 20% of recipients, and by 5 years, over half | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF IOWA, THE | $317,087 | Grant | Trans-NIH Recovery Act Research Support: The recent emergence of specialty cardiac hospitals has generated widespread controversy. Proponents suggest that such hospitals deliver higher quality and lower cost care, while critics contend that specialty lospitals cherry pick lower severity and more | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| UNIVERSITY OF HAWAII SYSTEMS | $232,529 | Grant | Trans-NIH Recovery Act Research Support: Mothers of an infant are much less likely to exercise regularly compared with women who have older children or no children. This low level of physical activity (PA) contributes to postpartum weight retention which can predict levels of obesity up to 15 ye | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $38,112 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): A Mediterranean Diet for Colon Cancer Prevention: Epidemiological and animal studies indicate that the major components of the traditional Cretan-Mediterranean diet have great promise for the prevention of colorectal c | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| BAYLOR COLLEGE OF MEDICINE | $145,768 | Grant | Trans-NIH Recovery Act Research Support: [Role of c-Cbl in IL-12 production in genetically enhanced DCs.] Dendritic cells (DCs) have been used in countless clinical trials for cancer. Nevertheless, clinical responses remain modest, possible | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $311,600 | Grant | Trans-NIH Recovery Act Research Support: A brief description of these initial and subsequent observations resulting from the parent grant?s support is included in the project summary and has not substantially changed. Using RNA differential display following cytokine withdrawal from a human myel | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| GROUP HEALTH COOPERATIVE | $466,076 | Grant | Trans-NIH Recovery Act Research Support: Despite the known efficacy of colorectal cancer screening (CRCS), 40 - 50% of eligible adults are not screened at recommended intervals, and many have never had any type of screening. Screening failures occur not only because of lack of testing, but also | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| GEORGIA HEALTH SCIENCES UNIVERSITY RESEARCH INSTITUTE, INC. | $282,897 | Grant | Trans-NIH Recovery Act Research Support: The stress response is an evolutionary conserved cellular response mechanism characterized by the enhanced synthesis and accumulation of heat shock proteins (Hsps). These proteins act as molecular chaperones and prevent aggregation of misfolded proteins; | Health and Human Services, Department of / National Institutes of Health | 8/27/2009 |
| DUKE UNIVERSITY | $103,522 | Grant | Trans-NIH Recovery Act Research Support: Urinary tract infections (UTIs) represent one of the most common bacterial infections of humans. Recurrence and persistence of UTIs, in spite of appropriate antibiotic therapry, has been attributed, at least in part, to the pathogen seeking intracellular | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $326,934 | Grant | Trans-NIH Recovery Act Research Support: No abstract available. | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $747,144 | Grant | Trans-NIH Recovery Act Research Support: Cationic Antimicrobial Peptides (CAMPs) constitute a conserved branch of the innate immune system and is thus one of the first lines of defense against bacterial infections. Several clinical antibiotics, such as colistin and other polymyxins, also belong | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $221,613 | Grant | Trans-NIH Recovery Act Research Support: The pluripotency of ES cells has engendered great excitement concerning their potential for cell replacement therapies for a variety of human diseases. There is particular excitement over the use of ES cells differentiated along the hematopoietic lineage. | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $4,245,533 | Grant | Trans-NIH Recovery Act Research Support: The project will procure, process and analyze knees from 100 humans age 20-90 at autopsy each year. The knees are analyzed macroscopically and by various imaging techniques. Tissues, cells, RNA, DNA and protein are isolated from the knees and distributed | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF CONNECTICUT | $3,666,207 | Grant | Trans-NIH Recovery Act Research Support: This program project is composed of four projects and three cores focused on the immune response to Category B and C Biodefense Pathogens and their products. The program theme is to define the parameters for development of protective immunity against vira | Health and Human Services, Department of / National Institutes of Health | 8/11/2009 |
| MOUNT SINAI SCHOOL OF MEDICINE | $7,935,507 | Grant | Trans-NIH Recovery Act Research Support: The applicant has been in the forefront of studies of the function of PB1-F2. Studies in cells have shown that PB1-F2 targets the mitochondrial membrane where it interacts with AMT3 and VDAC1 of the permeability transition pore complex causing the release | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| NEW YORK UNIVERSITY (INC) | $2,400,000 | Grant | Trans-NIH Recovery Act Research Support: Most Superfund sites are contaminated with mixtures of metals and organic chemicals and a major concern for human exposure to Superfund sites is the possibility of disease, and in particular, cancer induction. This SBRP competing application has two majo | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| OREGON HEALTH & SCIENCE UNIVERSITY | $608,525 | Grant | Trans-NIH Recovery Act Research Support: The perioculomotor area (pIII) is the main source of neuropeptide Urocortin 1 (Ucn1) in the brain. Ucn1 is an endogenous peptide related to the corticotropin-releasing factor (CRF) that has higher affinity to CRF receptors than CRF itself. In addition to | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| UNIVERSITY OF CALIFORNIA, DAVIS | $717,770 | Grant | Trans-NIH Recovery Act Research Support: Recruitment of leukocytes to acute sites of inflammation is a finely orchestrated process initiated by membrane expression and functional activation of leukocyte and endothelial cell adhesion molecules (CAMs) including selectins, integrins, and Ig-super f | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | $578,000 | Grant | Trans-NIH Recovery Act Research Support: Viruses alter cellular pathways to create an environment conducive for their replication cycles as well as to inactivate or escape cellular antiviral responses. Viruses also utilize cell proteins to facilitate or enhance virus-specific molecular processes | Health and Human Services, Department of / National Institutes of Health | 5/14/2009 |
| FRED HUTCHINSON CANCER RESEARCH CENTER | $1,943,911 | Grant | Trans-NIH Recovery Act Research Support: PROJECT NARRATIVE The results of this study will improve our understanding of the molecular processes of OSCC and lay the foundation for future longitudinal studies investigating whether the molecular signatures we identify may permit physicians to 1) scr | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $479,860 | Grant | Trans-NIH Recovery Act Research Support: Our primary objective is to utilize the molecular clock hypothesis to develop mathematical models that will allow us to study how cancers grow and spread. Human cancer growth cannot be directly observed and the overall goal is to develop an approach that | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| SCRIPPS RESEARCH INSTITUTE, THE | $620,126 | Grant | Trans-NIH Recovery Act Research Support: Our study seeks to develop efficacious new therapeutic agents for the treatment of cancer. We hypothesize that through the combination of chemistry and an immune effector we can prepare a versatile and effective new class of immunotherapeutics, chemically | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $556,784 | Grant | Trans-NIH Recovery Act Research Support: Lung cancer is the number one cancer killer in the United States, exceeding breast, colorectal, prostate, and melanoma malignancies combined. Of all newly diagnosed lung cancers, greater than eighty percent of these malignancies are non-small cell lung ca | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| CORNELL UNIVERSITY, INC | $554,976 | Grant | Trans-NIH Recovery Act Research Support: Cells continuously experience genome damage that, if not properly attended to, can cause developmental defects, premature aging, and increased cancer predisposition. DNA damage checkpoints defend against these consequences of genomic instability by regula | Health and Human Services, Department of / National Institutes of Health | 6/19/2009 |
| UNIVERSITY OF WASHINGTON | $1,233,952 | Grant | Trans-NIH Recovery Act Research Support: AbstractThis is a second revision of a renewal application (2 RO1 DA014050-06; Marijuana Dependence Treatment PRN) last reviewed in March of 2007 and submitted in response to NIDA's Behavioral and Integrative Treatment Development Program (PA-07-111). The | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| THE GEORGE WASHINGTON UNIVERSITY | $1,312,777 | Grant | Trans-NIH Recovery Act Research Support: Overall purpose: The project contains two Specific Aims. Aim 1 involves electrophysiological experiments using whole-cell, voltage-clamp recordings on chicken vestibular nuclei neurons, the principal cells of the chick tangential vestibular nucleus, in br | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| FLORIDA STATE UNIVERSITY, THE | $573,586 | Grant | Trans-NIH Recovery Act Research Support: Like humans, juvenile songbirds learn to imitate the vocal patterns of an adult during a sensitive period of development. Also like humans, songbird vocal patterns are controlled by a forebrain network that includes pre-motor, striatal, and auditory path | Health and Human Services, Department of / National Institutes of Health | 5/12/2009 |
| ST. JUDE CHILDREN'S RESEARCH HOSPITAL | $840,000 | Grant | Trans-NIH Recovery Act Research Support: The goal of the proposed research is to achieve in-depth understanding of the molecular mechanisms underlying the CNS pathogenesis in neurodegenerative GM1-gangliosidosis (GM1). This lysosomal storage disease (LSD) is caused by deficiency of lysosomal 2-g | Health and Human Services, Department of / National Institutes of Health | 5/29/2009 |
| THE VANDERBILT UNIVERSITY | $775,000 | Grant | Trans-NIH Recovery Act Research Support: Aim I: Synthesize Improved Nanocrystal Probes: Can we create highly stable and bright ultra-small, core/shell alloy nanocrystals for size-independent fluorescence labeling? Can we mate new buffer solubility strategies to our methodology for reducing non- | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $1,182,171 | Grant | Trans-NIH Recovery Act Research Support: Pathogenesis of glaucomatous optic nerve damage is the funded project title. The project studies how the disease glaucoma causes blindness in human eyes and uses animal models in rats and mice to study both how the disease damages the eye's tissues a | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| KANSAS STATE UNIVERSITY | $507,126 | Grant | Trans-NIH Recovery Act Research Support: The nature of protein-protein interactions of crystallins forms the basis for understanding the transparent and opaque properties of the normal and cataractous lens. Previous physical studies have suggested that weak, noncovalent interactions of these len | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $709,999 | Grant | Trans-NIH Recovery Act Research Support: Inflammation is a component of the corneal wound healing process. This proposal under the two-year support provided by the National Institutes of Health under the American Recovery and Reinvestment Act of 2009 will continue to test novel hypotheses about | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $734,908 | Grant | Trans-NIH Recovery Act Research Support: We seek to understand the circuitry of visual cortex, the rules underlying its activity-dependent development, and the computational functions these subserve. These understandings are critical to our understanding both of normal vision and of its central | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| THE CHILDRENS HOSPITAL LOS ANGELES | $805,312 | Grant | Trans-NIH Recovery Act Research Support: The long term goal of the research is to elucidate the cellular and molecular basis of excess scar formation during wound repair. Keloids are tumor-like skin scars that affect 10 to 20% of people of African descent, Asians, and Hispanics without appropria | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF MARYLAND BALTIMORE COUNTY | $506,203 | Grant | Trans-NIH Recovery Act Research Support: The first aim of this renewal is to test a conceptual model linking pre-college student charcteristics to student experience in the MSP and success in college, and in turn, the pathways from these college variables to PhD pursuit and receipt. This project | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $820,269 | Grant | Trans-NIH Recovery Act Research Support: The overarching goal of the Colorado Adoption Project (CAP) is to assess the genetic and environmental etiologies of individual differences in behavioral development. Toward this end, adoptive and nonadoptive probands and siblings have been tested almost | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| MAINE MEDICAL CENTER | $877,620 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of our research program is the elucidation of the molecular mechanisms underlying the angiogenic effects of Fibroblast Growth Factor 1 (FGF1), and the application of this knowledge for the regulation of angiogenesis in vivo. Unlike mos | Health and Human Services, Department of / National Institutes of Health | 6/21/2009 |
| UNIVERSITY OF ILLINOIS | $785,000 | Grant | Trans-NIH Recovery Act Research Support: With the support from the ARRA 2009, we will devote the next two years to test the deleterious effects of dematin deficiency on erythrocyte membrane stability with direct implications in improving our understanding of the molecular etiology of hemolytic a | Health and Human Services, Department of / National Institutes of Health | 8/01/2009 |
| GEORGIA HEALTH SCIENCES UNIVERSITY RESEARCH INSTITUTE, INC. | $977,179 | Grant | Trans-NIH Recovery Act Research Support: The overall goal of these continuing studies is to understand how endothelial nitric oxide synthase (eNOS) signaling is regulated in the pulmonary system with emphasis on its role in the perinatal period. We have recently demonstrated in vivo, that endoth | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $681,339 | Grant | Trans-NIH Recovery Act Research Support: This research proposes to use a newly developed 3D ultrasound method to measure volume blood flow. A wide variety of clinical applications would benefit from this development including estimation of cardiac output, monitoring of cerebrovascular diseases, | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| EMORY UNIVERSITY | $1,544,566 | Grant | Trans-NIH Recovery Act Research Support: Many studies have suggested a relationship between depression and cardiovascular disease (CVD), but its causal role in the etiology of CVD is still debated and the mechanisms are unclear. Rather than being causally related, depression and CVD could share | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION | $259,594 | Grant | Trans-NIH Recovery Act Research Support: The long-term goal of our research program is to use the meta-analytic approach to determine the effects of exercise and diet on health-related disease. The objective of this project is to quantitatively synthesize (meta-analyze) randomized controlled int | Health and Human Services, Department of / National Institutes of Health | 8/17/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $1,576,318 | Grant | Trans-NIH Recovery Act Research Support: Exhaled nitric oxide (NO) is a promising non-invasive tool to assess lung function, particularly in inflammatory diseases such as asthma. Traditional techniques, such as spirometry, are aimed at examining physical features of the lungs, such as airway ca | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| UNIVERSITY OF CHICAGO, THE | $921,031 | Grant | Trans-NIH Recovery Act Research Support: The ductus arteriosus (DA) is a fetal artery that allows blood ejected from the right ventricle to bypass the pulmonary circulation in utero. At birth, functional closure of the DA is initiated within minutes by O2-induced vasoconstriction. Functional clo | Health and Human Services, Department of / National Institutes of Health | 6/01/2009 |
| UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS | $1,087,420 | Grant | Trans-NIH Recovery Act Research Support: Elevations in the circulating level of C-reactive protein (CRP) are a strong predictor of the development of hypertension and insulin resistance. The proposed research program will determine how CRP and its cell surface receptors cause hypertension and in | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $845,412 | Grant | Trans-NIH Recovery Act Research Support: In adults, bone marrow (BM) is the major site for the continuous production of mature blood cells. Mature blood cells arise from hematopoieic stem cells (HSCs) within the bone marrow cavity. Although, the regulation of HSCs is an extremely popular area of | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $750,000 | Grant | Trans-NIH Recovery Act Research Support: Every year in the United States nearly 1 million deaths occur among the 7 million people affected with cardiovascular diseases. The dominant underlying factor for this disease includes elevated plasma low density lipoprotein (LDL)-cholesterol levels in as | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| GEORGIA TECH RESEARCH CORPORATION | $965,463 | Grant | Trans-NIH Recovery Act Research Support: Intravascular ultrasound (IVUS) imaging is a technology that enables realtime tomographic assessment of the arterial wall and it is increasingly employed to assist in selecting and evaluating therapeutic interventions. While new catheter designs have been | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $826,822 | Grant | Trans-NIH Recovery Act Research Support: The GABAA receptor is a ligand-gated chloride channel that, upon binding the neurotransmitter GABA, mediates neuronal inhibition throughout the brain. In addition to binding GABA, the receptor is allosterically modulated by a variety of therapeutic agents | Health and Human Services, Department of / National Institutes of Health | 5/07/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $937,960 | Grant | Trans-NIH Recovery Act Research Support: Mucolipidosis Type IV (MLlV) is a developmental disorder that is characterized by severe neurologic and ophthalmologic abnormalities. Classified as a lysosomal storage disorder, it is progressive and usually presents during the first year of life with men | Health and Human Services, Department of / National Institutes of Health | 6/15/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $984,000 | Grant | Trans-NIH Recovery Act Research Support: Alzheimer?s Disease (AD), the most common cause of dementia in the elderly, is characterized by the deposition of amyloid plaque and neurofibrillary tangles in the brain. Despite significant advances made toward our understanding of the pathogenesis of AD | Health and Human Services, Department of / National Institutes of Health | 8/04/2009 |
| WASHINGTON UNIVERSITY, THE | $1,396,978 | Grant | Trans-NIH Recovery Act Research Support: Deep brain stimulation (DBS) of the subthalamic nuclei (STN) substantially reduces motor symptoms in people with Parkinson disease (PD). However, STN DBS in PD also can alter cognitive control skills. How STN DBS improves motor function yet impairs cognit | Health and Human Services, Department of / National Institutes of Health | 9/01/2009 |
| TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | $891,169 | Grant | Trans-NIH Recovery Act Research Support: Our overall aim is to determine the molecular mechanisms of _-amyloid (A_)-induced synaptic loss and neuronal death. Deposition of insoluble A_, together with tangle formation, loss of synapses and neurons, are hallmarks of Alzheimer's disease. More recen | Health and Human Services, Department of / National Institutes of Health | 7/20/2009 |
| UNIVERSITY OF SOUTHERN CALIFORNIA | $893,979 | Grant | Trans-NIH Recovery Act Research Support: Dopamine-glutamate plasticity in nigrostriatal injury: Exercise-enhanced recovery Principal Investigators: Michael Jakowec, PhD, and John Walsh, PhD. University of Southern California. The primary goal of this research proposal is to elucidate the molecul | Health and Human Services, Department of / National Institutes of Health | 6/15/2009 |
| CHILDRENS HOSPITAL OF PHILADELPHIA | $740,250 | Grant | Trans-NIH Recovery Act Research Support: Cell migration is fundamental to normal central nervous system (CNS) development and perturbations in this process have been implicated in the pathogenesis of many neurologic disorders including epilepsy, mental retardation and autism. Understanding the p | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| CALIFORNIA INSTITUTE OF TECHNOLOGY | $876,725 | Grant | Trans-NIH Recovery Act Research Support: Mobilizing endogenous progenitor cells in the adult brain for treatment of neurodegenerative and demyelinating disease offers several advantages over transplantation of stem cells (SCs). The present project is investigating the ability of the cytokine leu | Health and Human Services, Department of / National Institutes of Health | 7/19/2009 |
| FIRSTSTRING RESEARCH, INC | $1,261,212 | Grant | Trans-NIH Recovery Act Research Support: The wound repair process in skin is initiated immediately after an injury and induces a cascade of events including inflammation, proliferation, and scar differentiation. The adverse changes in skin structure and function resulting from scar tissue affect | Health and Human Services, Department of / National Institutes of Health | 8/07/2009 |
| NEW YORK UNIVERSITY (INC) | $473,618 | Grant | Trans-NIH Recovery Act Research Support: Lymphocytes are highly motile cells that move through secondary lymphoid tissues at high speed in response to chemokines, temporarily arrest migration through formation of an immunological synapse when they encounter antigen, and then renew rapid migratio | Health and Human Services, Department of / National Institutes of Health | 5/21/2009 |
| CASE WESTERN RESERVE UNIVERSITY | $181,321 | Grant | Trans-NIH Recovery Act Research Support: The long term goal of this proposal is to understand, in detail, the process of cessation of mRNA translation. We have uncovered compelling evidence that shutting down mRNA translation is not simply a passive and default event in the lifetime of an mRNA, | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| MIAMI UNIVERSITY | $239,817 | Grant | Trans-NIH Recovery Act Research Support: Membrane proteins are responsible for many important properties and functions of biological systems: they transport ions and molecules across the membrane, they act as receptors, and they have roles in the assembly, fusion, and structure of cells and viru | Health and Human Services, Department of / National Institutes of Health | 8/12/2009 |
| UNIVERSITY OF ILLINOIS | $63,425 | Grant | Trans-NIH Recovery Act Research Support: The goal of this proposal is to investigate the role of myosin I in the nucleus. Nuclear myosin I is a member of the myosin superfamily of actin activated ATPases that is found in the nucleus. We have previously demonstrated that it is involved in transc | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, THE | $360,120 | Grant | Trans-NIH Recovery Act Research Support: Malaria currently threatens nearly half the world's population and is responsible for an estimated 500 million clinical cases and one to three million deaths a year. Although malaria can be controlled by public health interventions, throughout the tropics | Health and Human Services, Department of / National Institutes of Health | 8/10/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $321,124 | Grant | Trans-NIH Recovery Act Research Support: Association studies provide a powerful approach for locating alleles that contribute to disease susceptibility and phenotypic variation. Since population-genetic processes play a central role in generating patterns of statistical association between disea | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERISTY OF MISSISSIPPI MEDICAL CENTER | $129,352 | Grant | Trans-NIH Recovery Act Research Support: We have recently observed that coilin phosphorylation differentially affects its interaction with SMN and SmB. To address several questions stemming from this interesting observation, a supplement is requested. These funds will support a post-doc and gr | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| SOUTH CAROLINA RESEARCH FOUNDATION | $30,000 | Grant | Trans-NIH Recovery Act Research Support: Characterization of the Suf Fe-S Cluster Biosynthesis Pathway Under Stress Iron is critical for growth of bacterial pathogens due to the need for iron in heme and iron-sulfur (Fe-S) clusters. To combat infection, the human host uses two general strategies | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY | $289,931 | Grant | Trans-NIH Recovery Act Research Support: Protein-protein interactions (PPIs) play a central role in all biological processes. Akin to the complete sequencing of genomes, complete descriptions of interactomes is a fundamental step towards a deeper understanding of biological processes, and has a | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $271,604 | Grant | Trans-NIH Recovery Act Research Support: Replication licensing and cell cycle checkpoints ARRA DNA replication origins are licensed by the chromatin loading of the MCM helicase complex through the action of ORC, Cdc6, and Cdt1. We have previously shown that normal cells contain an active cell | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| KENNESAW STATE UNIVERSITY | $75,869 | Grant | Trans-NIH Recovery Act Research Support: The original proposal described the production of a series of mutant and chimeric enzymes and their study using kinetics models and stopped flow and steady state kinetics experiments. Ongoing work has revealed that the human signaling ancestors evolved f | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF TOLEDO, THE | $83,630 | Grant | Trans-NIH Recovery Act Research Support: We have identified a phosphorylated form of Borealin in mitotic cells and we and propose to analyze the role of this modification in the function of the chromosomal passenger complex (CPC). One additional student was recruited to carry out this project, | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| WAKE FOREST UNIVERSITY | $6,216 | Grant | Trans-NIH Recovery Act Research Support: While trials such as the Diabetes Prevention Program have demonstrated a significant potential for the prevention of type 2 diabetes mellitus (DM) through lifestyle interventions, a critical knowledge gap is whether such approaches can be implemented in t | Health and Human Services, Department of / National Institutes of Health | 6/22/2009 |
| LOUISIANA STATE UNIVERSITY SYSTEM | $25,986 | Grant | Trans-NIH Recovery Act Research Support: The parental R21 grant, which is under no cost extension, was proposed to investigate alcohol effects on gene and cytokine expression in human airway epithelial cells. The primary airway cells are cultured at an air-liquid interface to closely mimic in v | Health and Human Services, Department of / National Institutes of Health | 6/22/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $123,666 | Grant | Trans-NIH Recovery Act Research Support: The proposed studies examine mechanisms by which aging impairs wakefulness. First, we propose using a recently described novel technique that utilizes a tagged unfolded protein sensor to quantitatively measure misfolded proteins (Wen and Glenn, Molecular | Health and Human Services, Department of / National Institutes of Health | 9/04/2009 |
| RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | $7,725 | Grant | Trans-NIH Recovery Act Research Support: Dietary restriction extends lifespan, improves mid-life vigor, and retards age-related disease in many species. Mechanisms underlying these benefits are not well understood. Defining the cellular pathways by which dietary restriction is initiated and main | Health and Human Services, Department of / National Institutes of Health | 6/25/2009 |
| UNIVERSITY OF ROCHESTER | $31,556 | Grant | Trans-NIH Recovery Act Research Support: The goal of this summer supplement is to provide a summer research experience for a science educator. Effective influenza A vaccines represent a major public health need, both to combat annual virus outbreaks in at-risk populations, and also to protect a | Health and Human Services, Department of / National Institutes of Health | 6/04/2009 |
| WAYNE STATE UNIVERSITY (INC) | $64,765 | Grant | Trans-NIH Recovery Act Research Support: The overall purpose of the grant is the purchase of a dedicated GC/MS instrument for use in the elucidation of chemical reactions and combinatorial libraries. The expected outcomes ae the purchase of the instrument and an enhancement of the research outp | Health and Human Services, Department of / National Institutes of Health | 9/02/2009 |
| CHARLES DREW UNIVERSITY OF MEDICINE AND SCIENCE | $194,461 | Grant | Trans-NIH Recovery Act Research Support: This NCRR Science Education Partnership Award titled Would you like to be a scientist? Discover Biomedical Sciences! has two interrelated goals. On the one hand, it seeks to expose children from inner city elementary schools to the biomedical sciences, an | Health and Human Services, Department of / National Institutes of Health | 8/25/2009 |
| SEATTLE BIOMEDICAL RESEARCH INSTITUTE | $86,184 | Grant | Trans-NIH Recovery Act Research Support: Funds from this administrative supplement are being used to extend the impact of a three-year, summer science immersion program of a parental NIH grant from a two-week experience to a full year's worth of mentorship and hands-on learning for our BioQuest | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| UNIVERSITY OF NEBRASKA | $200,000 | Grant | Trans-NIH Recovery Act Research Support: The University of Nebraska State Museum, Soundprint Media Center, Inc. (SMCI), the NIH/NCRR-funded Nebraska Center for Virology, and the American Institute for Biological Sciences working with Carl Zimmer, a nationally recognized science writer, propose a | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| UNIVERSITY OF MAINE SYSTEM | $199,287 | Grant | Trans-NIH Recovery Act Research Support: This G?Nano-space ObservatoryG? supplement to the University of Southern Maine (USM) SEPA project (R25RR024280), G?Micro- and Nano-space Explorations of Health and DiseaseG? seeks to add within the current scope of the project the extensive use of user-fr | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| JOHNS HOPKINS UNIVERSITY, THE | $43,200 | Grant | Trans-NIH Recovery Act Research Support: Johns Hopkins-Fogarty African Bioethics Training Program (FABTP) Collaborative Website. This ARRA award is a supplement to an existing R25 Fogarty International Center (FIC) training grant provided to the Johns Hopkins-Fogarty African Bioethics Training P | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $108,000 | Grant | Trans-NIH Recovery Act Research Support: This project builds upon our Fogarty Framework Partnership between the University of California San Diego (UCSD) and San Diego State University (SDSU) (R25TW0075) to develop a Center of Expertise in Migration and Health (COEMH) in collaboration with other | Health and Human Services, Department of / National Institutes of Health | 9/03/2009 |
| WAKE FOREST UNIVERSITY | $181,702 | Grant | Trans-NIH Recovery Act Research Support: It is widely appreciated that reactive oxygen species (ROS) play a major role in the initiation of cancer, and they are also implicated in many cancer therapies, such as ionizing radiation, cisplatin and taxanes. More recently, it has been discovered that | Health and Human Services, Department of / National Institutes of Health | 8/28/2009 |
| CHILDRENS HOSPITAL OF PHILADELPHIA | $162,202 | Grant | Trans-NIH Recovery Act Research Support: The overall objective of this application is to develop an integrated biomedical-computing infrastructure incorporating audiologic, otologic and genetic patient data that will meet the needs of investigators pursuing patient-oriented pediatric hearing res | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| OAKLAND UNIVERSITY | $18,248 | Grant | Trans-NIH Recovery Act Research Support: Piezoimmunosensors (PZs) are biosensors in which antibodies are placed on a quartz crystal microbalance (QCM) to detect minute changes in mass as the antibodies bind with antigens. However, use of PZ technology in biosensors is problematic due to the comp | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE | $166,000 | Grant | Trans-NIH Recovery Act Research Support: Our data from the parent K99/R00 indicated that the TGF-β-induced TACE (TNF-α converting enzyme) activation/translocation plays a key role in the growth and invasiveness of HER2-overespressing breast cancer cells and mediates cell resistance to | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| PENNSYLVANIA STATE UNIVERSITY, THE | $50,000 | Grant | Trans-NIH Recovery Act Research Support: Cancer health disparities among African Americans are increasing. Vitamin D is suspected to play a role in several cancers and other chronic conditions with a higher incidence among African Americans. The actions of vitamin D are mediated through the vita | Health and Human Services, Department of / National Institutes of Health | 9/15/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $99,999 | Grant | Trans-NIH Recovery Act Research Support: Breast cancer is the second leading cause of death due to cancer among women in the United States. In 2007, approximately 213,000 women will be diagnosed with breast cancer, and about 41,000 of those will die from the disease this year. Obesity increases | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF MARYLAND | $100,000 | Grant | Trans-NIH Recovery Act Research Support: There are greater than 1,000,000 new cancer cases per year in the United States and cancer deaths exceed 500,000 annually. The acquisition of drug resistance in tumors is an ongoing problem in cancer therapy. Therefore, our broad aim is to understand the | Health and Human Services, Department of / National Institutes of Health | 9/23/2009 |
| UNIVERSITY OF ILLINOIS | $90,249 | Grant | Trans-NIH Recovery Act Research Support: This ARRA administrative supplement to the parent independent phase K22 award addresses 2 areas of scientific priority of the ARRA Supplement (NOT-OD-09-056): area (3); enhancing data collection, biological assays, instrumentation or measurement in existi | Health and Human Services, Department of / National Institutes of Health | 9/22/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $46,472 | Grant | Trans-NIH Recovery Act Research Support: This is an administrative supplement to NIAAA grant 7K23AA016936-02 (Principal Investigator: James MacKillop, PhD; Sponsor: Paul Roman, PhD), which is a career development award for Dr. James MacKillop to develop expertise using behavioral economics to i | Health and Human Services, Department of / National Institutes of Health | 7/13/2009 |
| RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL | $49,000 | Grant | Trans-NIH Recovery Act Research Support: ARRA funds allow for the further automation and reproducibility of our already established microscopy methods, through the purchase of an Olympus IX81 microscope and digital camera. This improved instrumentation will allow us to proceed in our project mor | Health and Human Services, Department of / National Institutes of Health | 8/15/2009 |
| MASSACHUSETTS GENERAL HOSPITAL, THE | $52,486 | Grant | Trans-NIH Recovery Act Research Support: Bipolar I disorder (BP-I) is a chronic disorder with recurrent depressed and/or manic mood episodes. Recurrent episodes of depression constitute the most functionally debilitating aspect for individuals with bipolar I disorder (BP-I). Mood stabilizers are | Health and Human Services, Department of / National Institutes of Health | 7/31/2009 |
| NEW YORK UNIVERSITY (INC) | $108,000 | Grant | Trans-NIH Recovery Act Research Support: Title: G?The Neurobiology of Adolescent DepressionG? Overall Purpose: Adolescent depression is a major public health concern due to its morbidity and mortality rates. Using special techniques of brain chemical imaging, this study compares brain concentra | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | $54,001 | Grant | Trans-NIH Recovery Act Research Support: Angiogenesis, necessary for tumor growth involves cell proliferation and directed migration. Thus, there is clearly a crucial role of cytoskeletal microtubule (MT) dynamics in angiogenesis; linking perturbations of MT dynamics to inhibition of tumor angio | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF ILLINOIS | $399,753 | Grant | Trans-NIH Recovery Act Research Support: The overall purpose of the Center for End-of-Life Transition Research is to advance the science of care for people facing the end-of-life transition across the life span (e.g., infants, children, adults, and older adults). We will emphasize patient-cente | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| OHIO STATE UNIVERSITY RESEARCH FOUNDATION | $205,875 | Grant | Trans-NIH Recovery Act Research Support: The Ohio State University (OSU) Neuroscience Center provides support for studies aimed at analysis and treatment of neurological disorders with an emphasis on animal models.. The Center is a collaborative effort of 43 neuroscientists (25 NINDS funded) fro | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| UNIVERSITY OF MIAMI | $729,110 | Grant | Trans-NIH Recovery Act Research Support: This award will accelerate and enhance the ongoing research within the Resource to research effects of aging on the nervous system and AlzheimerG??s disease. The specific aims of this supplement are: 1. Molecular characterization of the DG??Aspartate (D-A | Health and Human Services, Department of / National Institutes of Health | 8/20/2009 |
| REGENTS OF THE UNIVERSITY OF MICHIGAN | $38,698 | Grant | Trans-NIH Recovery Act Research Support: The Mission of the Center for neural Communication Technology (CNCT or Center) is to develop and provide microscale neural probe technologies for chronic, high fidelity neural interfaces to the central nervous system. To fulfill its mission, the Center ad | Health and Human Services, Department of / National Institutes of Health | 6/05/2009 |
| MARINE BIOLOGICAL LABORATORY, THE | $895,215 | Grant | Trans-NIH Recovery Act Research Support: This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in oth | Health and Human Services, Department of / National Institutes of Health | 9/17/2009 |
| UNIVERSITY OF CALIFORNIA, SAN DIEGO | $817,406 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION: The National Center for Microscopy and Imaging Research (NCMIR) was established to develop computer aided advanced microscopy for acquisition of structural and functional data in the dimensional range of 1 nm3 to 100 um3. With novel specimen | Health and Human Services, Department of / National Institutes of Health | 8/13/2009 |
| UNIVERSITY OF ARIZONA | $220,345 | Grant | Trans-NIH Recovery Act Research Support: Under this ARRA supplment a new collaboration will be developed between researchers at the University of North Carolina and the University of Arizona. Both groups have specific aims under their current Superfund Basic Research Program related to the diss | Health and Human Services, Department of / National Institutes of Health | 9/06/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $222,000 | Grant | Trans-NIH Recovery Act Research Support: ARRA -SBRP: Environmental Exposure and Effect of Hazardous Chemicals(Administrative Supplement) UNC Project 1 collaboration with Duke University Project 6 This collaborative research program between Duke and UNC will take full advantage of the strengths | Health and Human Services, Department of / National Institutes of Health | 9/10/2009 |
| UNIVERSITY OF CHICAGO, THE | $380,517 | Grant | Trans-NIH Recovery Act Research Support: Recombination rate variation and evolution in primates Abstract: Errors in the meiotic recombination process underlie a variety of chromosomal abnormalities, which are associated with spontaneous miscarriages and a wide range of human diseases. In spite o | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $204,024 | Grant | Trans-NIH Recovery Act Research Support: This is a competitive revision of the grant GM083849 'Microfluidics-based selections for the optimization of red fluorescent proteins.' The broad goal of this project is to develop fluorescent proteins with an 80-fold improvement in signal output (e.g. nu | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $211,690 | Grant | Trans-NIH Recovery Act Research Support: The goal of this administrative supplement is to address the contribution of phosphatase activity to regulation of kinetochore microtubule interactions in mitosis. The proposed experiments are a direct outgrowth of experiments that were conducted as part | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $276,190 | Grant | Trans-NIH Recovery Act Research Support: The goal of this work is a structure-based understanding of how DNA replication is initiated. Replication initiates at multiple sites on the genome called origins of DNA replication. Specialized protein complexes bind at these sites and prepare the duplex | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| UNIVERSITY OF WASHINGTON | $299,439 | Grant | Trans-NIH Recovery Act Research Support: In this supplement, we propose to use chronic myeloid leukemia (CML) as a test bed to accelerate the tempo of research in Aim 2 of the parent grant, namely, the development of supervised methods for the identification of biologically meaningful predictors | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| UNIVERSITY OF TEXAS AT AUSTIN | $271,398 | Grant | Trans-NIH Recovery Act Research Support: Mutations in voltage-dependent sodium channel genes cause neurological, muscular, and cardiac diseases. Although much is known about sodium channel function, there is still much to learn. The sodium channel is a large molecule and understanding which of i | Health and Human Services, Department of / National Institutes of Health | 7/17/2009 |
| TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | $147,772 | Grant | Trans-NIH Recovery Act Research Support: This research project help us to understand how anesthesia cause neurodegeneration and cognitive dysfunction by disruption of intracellular calcium homeostasis, especially abnormal calcium release from the ER and then calcium influx from extracellular spa | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| INTERNATIONAL BROTHERHOOD OF TEAMSTERS | $628,000 | Grant | Trans-NIH Recovery Act Research Support: The IBT provided worker safety and health training for workers who will be employed on stimulus funded environmental remediation projects, large scale construction projects, green projects, or are involved in the transportation of hazardous materials. Th | Health and Human Services, Department of / National Institutes of Health | 9/06/2009 |
| YALE UNIVERSITY | $50,000 | Grant | Trans-NIH Recovery Act Research Support: The ability to develop immunological memory to infectious diseases is critical for health and survival. These proposed studies will help elucidate how memory functions in order to better understand natural immunity and improve vaccine design. | Health and Human Services, Department of / National Institutes of Health | 9/11/2009 |
| UNIVERSITY OF MASSACHUSETTS | $75,000 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this request is for an administrative supplement to complete an ongoing process that is aimed at developing a Portable Instrument Evaluation Service (PIES) that will be made available to all IDDRC investigators at the University of Massachu | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $99,999 | Grant | Trans-NIH Recovery Act Research Support: Purchase of a state of the art Light Microscope with High Quality Imaging Performance for UCLA IDDRC Imaging Core Facility which serves 15 Principal Investigators and nearly 35 researchers and students. | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| UNIVERSITY OF CALIFORNIA, LOS ANGELES | $397,641 | Grant | Trans-NIH Recovery Act Research Support: This competitive renewal application to continue a Resource for Computational Anatomy and Multidimensional Modeling will go beyond current atlases and maps of brain that assume a static morphology and prohibit the examination of time varying changes. Buil | Health and Human Services, Department of / National Institutes of Health | 9/07/2009 |
| SAN DIEGO STATE UNIVERSTIY FOUNDATION | $116,176 | Grant | Trans-NIH Recovery Act Research Support: The administrative supplemental studies are in support of the active NIH research grant, 5 R01 AG026727 ('Dendritic cells of the aged'). The goal of the studies is to elucidate the role of alveolar macrophages in the increased inflammatory milieu in the | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| YALE UNIVERSITY | $478,004 | Grant | Trans-NIH Recovery Act Research Support: High resolution structural, functional and spectroscopic magnetic resonance (MR) imagings of the brain are powerful technologies for the study of epilepsy. Image-guided surgical resection has proven to be an effective treatment for many cases of medically | Health and Human Services, Department of / National Institutes of Health | 9/25/2009 |
| YALE UNIVERSITY | $188,870 | Grant | Trans-NIH Recovery Act Research Support: The primary goal of this supplementary application is to develop a potent beta-peptide agonist of the GLP-1 receptor, a validated target for the treatment of type 2 diabetes. The experimental plan builds solidly on a foundation of results obtained in our | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | $463,653 | Grant | Trans-NIH Recovery Act Research Support: UNC Developmental Disabilities Research Center. IDDRC portion of supplement: The Developmental Neuroimaging Laboratory is a core facility for the UNC IDDRC. We requested a supplement to our core to enable the acquisition and analysis of electrophysiol | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| TRUSTEES OF INDIANA UNIVERSITY | $48,299 | Grant | Trans-NIH Recovery Act Research Support: This is a request for an administrative supplement to NIAAA grant R01 AA016789. The requested amount is for purchase of the core components of a new model Laser Microdissection System for my lab. A Laser Microdissection System is needed for Aim 3 of thi | Health and Human Services, Department of / National Institutes of Health | 9/21/2009 |
| UNIVERSITY OF KENTUCKY | $95,857 | Grant | Trans-NIH Recovery Act Research Support: Alcoholism, alcohol abuse, and the medical complications of excessive drinking are major world-wide health problems. Alcohol is a tumor promoter. Epidemiological studies indicate that heavy alcohol consumption increases risk of breast cancer and is associ | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| REGENTS OF THE UNIVERSITY OF COLORADO, THE | $22,422 | Grant | Trans-NIH Recovery Act Research Support: This proposal seeks renewal of R01 AG006537 for years 20-24 to provide continuing support for our work in the integrative physiology of human aging. The proposed research will determine if caloric restriction- induced weight loss improves vascular endothe | Health and Human Services, Department of / National Institutes of Health | 7/14/2009 |
| UNIVERSITY OF PITTSBURGH THE | $234,160 | Grant | Trans-NIH Recovery Act Research Support: It has been recently discovered that in addition to resident tenocytes, tendons host another population of cells, termed tendon stem cells (TSCs). TSCs are characterized by their multidifferentiation potential, including non-tenocyte lineages, such as ad | Health and Human Services, Department of / National Institutes of Health | 9/18/2009 |
| CHILDREN'S RESEARCH INSTITUTE | $387,724 | Grant | Trans-NIH Recovery Act Research Support: Facioscapulohumeral muscular dystrophy (FSHD) is linked to a shortened 3.3 kb D4Z4 repeat array from 11-100 to 1-10 copies on the subtelomeric region of chromosome 4q35. The shortening of the D4Z4 array is believed to have a de-repression effect on genes | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| UNIVERSITY OF WISCONSIN SYSTEM | $416,434 | Grant | Trans-NIH Recovery Act Research Support: The parent grant (Procollagen C-proteinase Enhancers: In vivo Roles, R01 AR53815) for this Revision Application involves study of PCOLCE1-null, PCOLCE2-null, and PCOLCE1/PCOLCE2 doubly null mice to determine in vivo roles of PCOLCE 1 and 2 which enhance b | Health and Human Services, Department of / National Institutes of Health | 9/24/2009 |
| UNIVERSITY OF WASHINGTON | $302,751 | Grant | Trans-NIH Recovery Act Research Support: The PI, Dr. E. P. Greenberg has worked on quorum sensing for over 25 years. His long-term goals are to investigate the molecular mechanisms of social activity in bacteria, and to learn about why, when, where and how cooperative behavior exists. The reques | Health and Human Services, Department of / National Institutes of Health | 9/09/2009 |
| UNIVERSITY OF FLORIDA | $394,789 | Grant | Trans-NIH Recovery Act Research Support: Insight into post-transcriptional regulatory mechanisms will be sought through the study of a novel paradigm in global regulation, the carbon storage regulatory (Csr) system of Escherichia coli. Csr includes CsrA, an RNA binding protein that regulates tra | Health and Human Services, Department of / National Institutes of Health | 7/15/2009 |
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | $166,813 | Grant | Trans-NIH Recovery Act Research Support: Cancer arises from the uncontrolled proliferation of cells. Cell cycle regulatory proteins control the extent of cell proliferation. CUL2-based protein complexes degrade cell cycle regulators. Inactivation of particular CUL2 complex components is assoc | Health and Human Services, Department of / National Institutes of Health | 8/31/2009 |
| UNIVERSITY OF CALIFORNIA, IRVINE | $193,192 | Grant | Trans-NIH Recovery Act Research Support: One of the major goals in current proteomics research is to elucidate protein functions by globally mapping protein-protein interactions. A key step toward gaining a full understanding of the function of a macromolecular protein complex is to characterize | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA | $160,791 | Grant | Trans-NIH Recovery Act Research Support: Preliminary studies have led to the discovery that the redox modulatory site is part of a high affinity metal binding site site on the extracellular face of the Cav3.2 T-type channel. Endogeneous levels of trace metals are high enough to fill this site an | Health and Human Services, Department of / National Institutes of Health | 9/30/2009 |
| SRI INTERNATIONAL | $478,584 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION: The completion of the genome sequence for an organism such as a disease-causing bacterium marks the start of a new era of accelerated research on that organism. The huge quantity of data and knowledge defined by the genome sequence, and by th | Health and Human Services, Department of / National Institutes of Health | 8/14/2009 |
| RAND CORPORATION. THE | $110,226 | Grant | Trans-NIH Recovery Act Research Support: DESCRIPTION (provided by applicant): The RAND Population Research Center (PRC) was established to address critical scientific and policy questions generated by major demographic changes, to apply the most rigorous, advanced research methods in studying th | Health and Human Services, Department of / National Institutes of Health | 9/28/2009 |
| BETH ISRAEL DEACONESS MEDICAL CENTER INC | $376,171 | Grant | Trans-NIH Recovery Act Research Support: Nonhuman primates (NHPs) provide powerful animal models for exploring the pathogenesis of infectious and noninfectious diseases, and for testing of new therapies and vaccines that cannot be evaluated in rodents. Over the past decade, the number of NIH gra | Health and Human Services, Department of / National Institutes of Health | 9/16/2009 |
| HARVARD COLLEGE, PRESIDENT & FELLOWS OF | $100,000 | Grant | Trans-NIH Recovery Act Research Support: The purpose of this supplement is to obtain funding to purchase a high mass accuracy mass spectrometer to support work being done under the parent grant. The parent grant seeks to establish the targets of a large family of human deubiquitinating enzymes u | Health and Human Services, Department of / National Institutes of Health | 7/16/2009 |
| THOMAS JEFFERSON UNIVERSITY | $386,250 | Grant | Trans-NIH Recovery Act Research Support: G protein-mediated signaling pathways regulate numerous physiological responses, including cardiovascular function, neurotransmitter responses, cell differentiation, cell migration, immune cell function, and smell, taste, and vision; and dysregulation of | Health and Human Services, Department of / National Institutes of Health | 9/29/2009 |
| UNIVERSITY OF MASSACHUSETTS | $137,786 | Grant | Trans-NIH Recovery Act Research Support: The award was made to fund a novel technical approach to one of the Aims of the parent grant. The goal is to develop a sister-chromatid exchange assay to allow us to measure replication-coupled recombination in vivo. Such a capability would allow us to i | Health and Human Services, Department of / National Institutes of Health | 6/18/2009 |