Philadelphia County, Pa., funds by Health and Human Services, Department of

Listing $463,269,429.43 in stimulus funds from Health and Human Services, Department of for Philadelphia

Note: For some programs where states do not report where money will be distributed across the state, we do not have the allocation for individual counties. Those programs include: Medicaid, unemployment benefits and food stamps. Those amounts are included in the totals for where the state agency receiving that money is located.

Amount refers to both the amount of stimulus funding going toward the project and the face value of the loan.

Recipient	Amount	Description	Federal Dept./Agency	Date
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$12,998,888	National Center for Research Resources, Recovery Act Construction Support The University of Pennsylvania proposes to catalyze the formation of the PENN Center for Chronobiology through construction of 46,204 gross square feet (gsf) of contiguous space in the Translational Research Building, thereby u uniting basic scientists stud... Show more See details	National Institutes of Health	3/18/2010
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$11,851,780	National Center for Research Resources, Recovery Act Construction Support This grant will support the construction of a contiguous research facility on the 8th and 9th floors of the new Temple University School of Medicine building which is currently unoccupied 'shelled' space. The facility will housuse the new Temple Institute f... Show more See details	National Institutes of Health	3/04/2010
CHILDRENS HOSPITAL OF PHILADELPHIA	$10,176,187	Trans-NIH Recovery Act Research Support Mental illnesses are common disorders that emerge during childhood and adolescence and many persisting into adulthood, with debilitating consequences. To prevent or intervene in this pathway it is essential to identify premorbid risk factors and early man See details	National Institutes of Health	9/30/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$10,071,173	Trans-NIH Recovery Act Research Support Advances in genomics are revolutionizing medicine with novel discoveries that help understand mechanisms and design novel treatments. For mental illnesses to join genomics we need robust phenotypic developmental data linked to brain function. The goal of See details	National Institutes of Health	9/30/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$8,925,401	Trans-NIH Recovery Act Research Support This project proposes to test a novel strategy financial incentives to improve uptake of comparative effectiveness findings among physicians and patients to reduce cardiovascular risk. This project will focus on improving cholesterol control among This spending item is part of a $12,488,763 allocation. See details	National Institutes of Health	9/16/2010
City of Philadelphia	$8,330,086	ARRA - Community Services Block Grant Funds are awarded to the existing network of Community Action Agencies, who must receive 99% of the funds appropriated. Funds are to be used for activities serving the population at or below 200% of the federal poverty level, as established by the Office This spending item is part of a $42,332,166 allocation. See details	Administration for Children and Families	4/10/2009
FOX CHASE CANCER CENTER	$8,000,000	National Center for Research Resources, Recovery Act Construction Support Animal research at the Fox Chase Cancer Center is an important and rapidly expanding part of the overall research program. Significant scientific accomplishments using animals at Fox Chase include the discovery and developmentnt of the Severe Combined Immu... Show more See details	National Institutes of Health	8/21/2009
AMERICAN COLLEGE OF RADIOLOGY, THE	$7,429,016	Recovery Act Comparative Effectiveness Research - AHRQ Coronary CT angiography (CCTA) represents a potentially disruptive technology in terms of its impact on the clinical evaluation and management of coronary artery disease (CAD). This was highlighted by its inclusion in the Consensus Report on Inititial Natio... Show more This spending item is part of a $9,666,726 allocation. See details	Agency for Healthcare Research and Quality	9/28/2010
Federation Day-Care Services	$7,174,233	ARRA Child Care and Development Block Grant The American Recovery and Reinvestment Act (ARRA) Child Care and Development Fund (CCDF) funds have two mandatory earmarks, Infant/Toddler and Quality. The Infant/Toddler funds are utilized for new center-based Keystone Babies programs. Specifically, th This spending item is part of a $60,146,767 allocation. See details	Administration for Children and Families	4/09/2009
THOMAS JEFFERSON UNIVERSITY	$6,651,849	National Center for Research Resources, Recovery Act Construction Support Thomas Jefferson University has determined that Jefferson Alumni Hall (JAH), which was constructed in 1968, has at least 40 more years of useful life from the perspective of its structural integrity. However, the laboratories r require renovation to meet mo... Show more See details	National Institutes of Health	1/25/2010
ESPERANZA HEALTH CENTER, INC.	$6,552,799	ARRA Health Center Integrated Services Development Initiative[g1] Esperanza Health Center (EHC) will construct a new health care facility within our current service area, at 4417 N. 6th St. EHC?s main goals are to increase access to primary care for the un/underinsured, improve the efficiency and effffectiveness of servic... Show more See details	Health Resources and Services Administration	10/19/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$6,338,720	Trans-NIH Recovery Act Research Support The NHLBI portfolio of genetic association studies does not currently include a large, well characterized study of South Asians, even though the burden of coronary heart disease (CHD) among South Asians is high and rapidly increasing. We propose that the This spending item is part of a $7,967,526 allocation. See details	National Institutes of Health	9/29/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$5,404,364	Trans-NIH Recovery Act Research Support The proposed IT infrastructure will provide a state of the art platform on which to build, test, and deploy large scale behavioral intervention studies and advance the science at the intersection of behavioral economics and health. We will provide linkage See details	National Institutes of Health	9/24/2009
Federation Day-Care Services	$4,550,456	ARRA Child Care and Development Block Grant The American Recovery and Reinvestment Act (ARRA) Child Care and Development Fund (CCDF) funds have two mandatory earmarks, Infant/Toddler and Quality. The Infant/Toddler funds are utilized for new center-based Keystone Babies programs. Specifically, th This spending item is part of a $60,146,767 allocation. See details	Administration for Children and Families	4/09/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$4,340,692	Trans-NIH Recovery Act Research Support Alzheimer's disease affects over 5 million people in the US costing the Federal Government over $100 billion dollars/year. Because our population is aging, in 2050, if the disease remains untreatable, there will be 16 million people in the US with AD cos This spending item is part of a $5,401,791 allocation. See details	National Institutes of Health	9/29/2009
PHILADELPHIA DEPT OF PUBLIC HEALTH	$4,329,571	ARRA - Prevention and Wellness--Communities Putting Prevention to Work This past quarter, PhiladelphiaG??s CPPW was able to make great strides in in completing its main tobacco control objectives. An executive order made 183 recreation centers, playgrounds, and outdoor pools smoke-free, affecting ovever 3.7 million visits. New... Show more This spending item is part of a $10,356,927 allocation. See details	Centers for Disease Control and Prevention	3/19/2010
PHILADELPHIA DEPT OF PUBLIC HEALTH	$4,235,354	ARRA - Prevention and Wellness--Communities Putting Prevention to Work PhiladelphiaG??s nutrition and physical activity challenges are daunting: nearly half of children are overweight or obese, low-income communities have little access to healthy foods, and opportunities for physical activity in schohools, neighborhoods, and w... Show more This spending item is part of a $15,018,277 allocation. See details	Centers for Disease Control and Prevention	3/19/2010
CHILDRENS HOSPITAL OF PHILADELPHIA	$4,215,211	Trans-NIH Recovery Act Research Support Mesenchymal stromal cells (MSCs), designated mesenchymal stem cells by some investigators, hold promise for the future therapy of diseases in nearly all tissues in the body. This application addresses Thematic Area 2, 'Translating Basic Science Discoverie See details	National Institutes of Health	9/23/2010
MATERNITY CARE COALITION	$4,052,396	ARRA - Early Head Start Provide Early Head Start services through the expansion of two existing locations, Norristown and South Philadelphia, with an additional new site in Pottstown, PA. Services will be provided to 168 additional families which includes 61 pregnant, 57 home See details	Administration for Children and Families	11/18/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$3,990,198	Trans-NIH Recovery Act Research Support The overarching goal of this project is to develop a coordinated, multidisciplinary center for the generation and synthesis of evidence to support the translation of genomic tests into improvements in cancer prevention, screening, diagnosis, treatment and See details	National Institutes of Health	9/29/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$3,990,198	Trans-NIH Recovery Act Research Support The Center for Comparative Effectiveness in Genomic Medicine (CEGeM) is housed within the Abramson Cancer Center at the University of Pennsylvania and closely linked to the participating departments and centers at Penn. CEGeM brings together investigators See details	National Institutes of Health	9/29/2009
GREATER PHILADELPHIA HEALTH ACTION, INCORPORATED	$3,937,796	ARRA Health Center Integrated Services Development Initiative[g1] GPHA is proposing to better address the needs of the medically needy and economically disadvantaged community of SW Philadelphia. Project 1 proposes the expansion of the 3rd floor at the 50th/Woodland Ave location to expand access to o medical care. Proj... Show more See details	Health Resources and Services Administration	10/19/2009
GREATER PHILADELPHIA HEALTH ACTION, INCORPORATED	$3,937,796	ARRA Health Center Integrated Services Development Initiative[g1] ARRA - Facility Investment Program GPHA is proposing to better address the needs of the medically needy and economically disadvantaged community of SW Philadelphia. Project 1 proposes the expansion of the 3rd floor at the 50th/Woodlanand Ave location to ex... Show more See details	Health Resources and Services Administration	10/19/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$3,276,074	Trans-NIH Recovery Act Research Support Coronary heart disease is the leading cause of mortality in both men and women worldwide and incidence is highly correlated with levels of cholesterol and triglycerides (fat) in the blood. Plasma concentrations of LDL and HDL cholesterol, as well as trig This spending item is part of a $4,700,000 allocation. See details	National Institutes of Health	9/28/2009
The Food Trust	$2,932,809	ARRA - Prevention and Wellness--Communities Putting Prevention to Work PhiladelphiaG??s nutrition and physical activity challenges are daunting: nearly half of children are overweight or obese, low-income communities have little access to healthy foods, and opportunities for physical activity in schohools, neighborhoods, and w... Show more This spending item is part of a $15,018,277 allocation. See details	Centers for Disease Control and Prevention	3/19/2010
CARING PEOPLE ALLIANCE	$2,843,786	ARRA Child Care and Development Block Grant The American Recovery and Reinvestment Act (ARRA) Child Care and Development Fund (CCDF) funds have two mandatory earmarks, Infant/Toddler and Quality. The Infant/Toddler funds are utilized for new center-based Keystone Babies programs. Specifically, th This spending item is part of a $60,146,767 allocation. See details	Administration for Children and Families	4/09/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$2,674,939	Trans-NIH Recovery Act Research Support The joint recruitment of a Physician Scientist into the Departments of Medicine and Cancer Biology will complement and synergize with the current faculty and research strengths to broaden the ACC expertise in tumor metabolism or tumor immunology. See details	National Institutes of Health	9/30/2009
PHILADELPHIA, SCHOOL DISTRICT OF	$2,672,835	ARRA - Head Start This award provides for ARRA Cost of Living Adjustment (COLA) and Quality Improvement Funding consistent with the provisions of Section 640(a)(5) of the Head Start Act for the Head Start program. Head Start promotes the school readiness of low-income chil This spending item is part of a $3,033,980 allocation. See details	Administration for Children and Families	6/17/2009
AMERICAN COLLEGE OF RADIOLOGY, THE	$2,554,108	Trans-NIH Recovery Act Research Support American College of Radiology Imaging Network (ACRIN) - Early Phase Imaging in Therapeutic Clinical Trials. This supplement enables ACRIN to extend its activities with respect to the development of 2 important molecular imaging agents including 18F fluoro This spending item is part of a $3,088,082 allocation. See details	National Institutes of Health	8/12/2009
GREATER PHILADELPHIA HEALTH ACTION, INCORPORATED	$2,500,000	ARRA Health Center Integrated Services Development Initiative[g1] The CIP will provide GPHA with the ability to upgrade and renovate patient waiting and examination areas. Also implementation of an electronic health record (EHR) will accommodate improved evaluation of patient outcomes, in real time,e, and will accommodat... Show more See details	Health Resources and Services Administration	6/25/2009
GREATER PHILADELPHIA HEALTH ACTION, INCORPORATED	$2,500,000	ARRA Health Center Integrated Services Development Initiative[g1] The Capital Improvement Program grant will provide GPHA with the ability to upgrade and renovate patient waiting and examination areas. The upgrades will allow us to make improvements at 6 sites as well as to purchase new medical equipipment such as exam ta... Show more See details	Health Resources and Services Administration	6/25/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$2,466,755	Trans-NIH Recovery Act Research Support Our ability to deliver high quality health care depends on the successful conduct of research on both the comparative effectiveness of different health care interventions (including drugs, devices, diagnostics, and organizational policies) and strategies See details	National Institutes of Health	9/30/2010
ALBERT EINSTEIN HEALTHCARE NETWORK	$2,385,757	NCI's Community Cancer Centers Program (NCCCP) - The network of community hospitals is a complex pilot program whose mission is, through research, to determine ways to bring state of the art cancer care and clinical trials to patients in their local comm This spending item is part of a $75,135,000 allocation. See details	National Institutes of Health	9/04/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$2,082,985	Trans-NIH Recovery Act Research Support Specific Aims: Acute Lung Injury (ALI) is a common complication of sepsis and trauma and is associated with mortality of over 20%. Candidate gene studies suggest a role for common genetic variation in determining host susceptibility to ALI in critically This spending item is part of a $4,676,664 allocation. See details	National Institutes of Health	9/25/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$1,993,826	Trans-NIH Recovery Act Research Support Proper immune responses are necessary to control pathogenic infections. It is equally important to limit immunological responses properly so that they do not cause chronic inflammation or autoimmune diseases. Thus, understanding molecular and cellular p This spending item is part of a $2,708,532 allocation. See details	National Institutes of Health	7/22/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$1,967,936	Trans-NIH Recovery Act Research Support This application details the expansion and upgrade of a Clinical Vector Core facility at The Children's Hospital of Philadelphia (CHOP). We are proposing the construction of a new manufacturing suite and the simultaneous renovation of an existing cGMP man See details	National Institutes of Health	3/31/2010
REGENX BIOSCIENCES, LLC	$1,907,246	Trans-NIH Recovery Act Research Support The goal of this project is to develop a gene therapeutic for retinitis pigmentosa (RP). RP is the most common inherited form of blindness, and is characterized by photoreceptor loss, leading to a progressive loss of peripheral as well as night vision. This spending item is part of a $2,822,695 allocation. See details	National Institutes of Health	7/26/2010
URBAN LEAGUE OF PHILADELPHIA	$1,866,192	ARRA Child Care and Development Block Grant The American Recovery and Reinvestment Act (ARRA) Child Care and Development Fund (CCDF) funds have two mandatory earmarks, Infant/Toddler and Quality. The Infant/Toddler funds are utilized for new center-based Keystone Babies programs. Specifically, th This spending item is part of a $60,146,767 allocation. See details	Administration for Children and Families	4/09/2009
WISTAR INSTITUTE OF ANATOMY & BIOLOGY	$1,683,608	Trans-NIH Recovery Act Research Support It is the primary objective of this program to elucidate correlates of immune-mediated protection against HIV-1 infection using pre-clinical animal models. To this end, Project 1 will determine humoral and cell-mediated immune responses to an attenuated S This spending item is part of a $5,581,859 allocation. See details	National Institutes of Health	9/01/2009
DELAWARE VALLEY COMMUNITY HEALTH, INC.	$1,626,760	ARRA Health Center Integrated Services Development Initiative[g1] Delaware Valley Community Health (DVCH) is applying for alterations and renovations for the Norristown Regional Health Center (NRHC); expansion of their current electronic health record (EHR) system to an organizational wide system; anand purchase of practi... Show more See details	Health Resources and Services Administration	6/25/2009
THOMAS JEFFERSON UNIVERSITY	$1,611,960	Trans-NIH Recovery Act Research Support We have developed a safe and effective transplant approach for both matched sibling and haploidentical related transplants which addresses the problem of donor availability in patients with leukemia, lymphoma, and related disorders. This approach has been This spending item is part of a $1,953,226 allocation. See details	National Institutes of Health	9/28/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$1,589,249	Trans-NIH Recovery Act Research Support This is supplemental funding request for a multidisciplinary combined modality program project grant with two major clinical protocols, both dealing with the use of photodynamic therapy (PDT), one for intraperitoneal carcinomatosis and the other for carci See details	National Institutes of Health	8/31/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$1,559,733	Trans-NIH Recovery Act Research Support This award provides for the recruitment of a scientist dedicated to the basic and translational research of angiogenesis andtumor microenvironment proposed in this application supports three of the scientific priorities of theentities: 1) to understand cr See details	National Institutes of Health	9/28/2009
PUBLIC HEALTH MANAGEMENT CORPORATION	$1,499,024	Recovery Act Comparative Effectiveness Research - AHRQ Adapting hypertension and diabetes guides for hard-to-reach African American men See details	Agency for Healthcare Research and Quality	9/28/2010
THOMAS JEFFERSON UNIVERSITY	$1,488,761	Trans-NIH Recovery Act Research Support This proposal brings together a unique multidisciplinary team of leading experts in alcohol studies and real time dynamic fluorescence imaging of cells and subcellular structures in intact tissues, high resolution electron tomography, sophisticated molecu This spending item is part of a $1,980,291 allocation. See details	National Institutes of Health	9/28/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$1,478,027	Trans-NIH Recovery Act Research Support The overall purpose of the study is to extend instrumental variables methods for binary outcomes to account for departures from the usual assumptions, to modeling the effects multiple treatments, to disseminate software, and to apply the methods developed See details	National Institutes of Health	9/27/2010
PHILADELPHIA, SCHOOL DISTRICT OF	$1,468,718	ARRA - Prevention and Wellness--Communities Putting Prevention to Work PhiladelphiaG??s nutrition and physical activity challenges are daunting: nearly half of children are overweight or obese, low-income communities have little access to healthy foods, and opportunities for physical activity in schohools, neighborhoods, and w... Show more This spending item is part of a $15,018,277 allocation. See details	Centers for Disease Control and Prevention	3/19/2010
CHILDRENS HOSPITAL OF PHILADELPHIA	$1,422,147	Trans-NIH Recovery Act Research Support This project addresses the NHLBI RC2 GO application entitled 'Characterizing Differentiated Heart, Lung, and Blood Cells Derived by Reprogramming Human Embryonic and Induced Pluripotent Stem Cells.' Emerging technologies to generate induced pluripotent st This spending item is part of a $1,962,019 allocation. See details	National Institutes of Health	9/28/2009
CARING PEOPLE ALLIANCE	$1,412,438	ARRA Child Care and Development Block Grant The American Recovery and Reinvestment Act (ARRA) Child Care and Development Fund (CCDF) funds have two mandatory earmarks, Infant/Toddler and Quality. The Infant/Toddler funds are utilized for new center-based Keystone Babies programs. Specifically, th This spending item is part of a $60,146,767 allocation. See details	Administration for Children and Families	4/09/2009
FOX CHASE CANCER CENTER	$1,389,172	Trans-NIH Recovery Act Research Support For the 100 years of its history, Fox Chase Cancer Center (FCCC) has been guided by a singular mission to reduce the burden of human cancer. Its 1904 hospital charter called for 'the study of the cause, treatment and prevention of cancer and for the disse See details	National Institutes of Health	9/21/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$1,369,130	Recovery Act Comparative Effectiveness Research - AHRQ Dissemination is an important, but neglected component of the research process. Currently, efforts focus on disseminating interventions that have been developed and evaluated through randomized trials; however, mechanisms are also needed to disseseminate th... Show more This spending item is part of a $1,414,898 allocation. See details	Agency for Healthcare Research and Quality	8/26/2010
THOMAS JEFFERSON UNIVERSITY	$1,345,621	Trans-NIH Recovery Act Research Support The experiments in this project are designed to generate improved vaccines against HIV-1 based on recombinant vesicular stomatitis viruses. The vaccine vectors developed in this project will be compared with recombinant RV and NDV vectors generated in pro This spending item is part of a $2,676,279 allocation. See details	National Institutes of Health	9/01/2009
COVENANT HOUSE INC	$1,300,000	ARRA Health Center Integrated Services Development Initiative[g1] Development of new access point to reach newly uninsured due to job loss, more accessable for seniors to provide primary care services, prevenative screening and education. See details	Health Resources and Services Administration	2/26/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$1,281,866	Trans-NIH Recovery Act Research Support Although the first successful human gene therapy was performed in XSCID patients, the occurrence of T cell leukemia in five of twenty successfully treated patients three to six years following treatment has shown that gene therapy is not without potential See details	National Institutes of Health	6/04/2009
THOMAS JEFFERSON UNIVERSITY	$1,276,630	Trans-NIH Recovery Act Research Support Preliminary data on proteins secreted by adipose tissue in the obese with high BP (OHBP) and obese with normal BP (ONBP) indicate a pro-inflammatory profile in OHBP (lower adiponectin, higher interleukin 6, higher plasminogen activator inhibitor-1) compar This spending item is part of a $1,418,884 allocation. See details	National Institutes of Health	8/14/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$1,273,266	Trans-NIH Recovery Act Research Support This project is designed to identify genetic variants that confer susceptibility to common forms of epilepsy including i) forms of idiopathic generalized epilepsy (IGE) such as juvenile myoclonic epilepsy (JME), childhood absence epilepsy (CAE) and idiopa This spending item is part of a $1,820,924 allocation. See details	National Institutes of Health	9/20/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$1,272,874	Trans-NIH Recovery Act Research Support Patients with probable Alzheimer s disease (AD) have semantic memory difficulty. In the previous funding period, we demonstrated that this is due to several factors, including degraded knowledge of the features that contribute to concepts; and an impairme This spending item is part of a $1,482,648 allocation. See details	National Institutes of Health	8/14/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$1,217,560	Trans-NIH Recovery Act Research Support Our current treatment algorithms provide for treating all patients with advanced colorectal cancer (and in the future, possibly those with stages II and III) with combined chemotherapy and bevacizumab. While the therapeutic benefit has been marked, it has This spending item is part of a $1,313,831 allocation. See details	National Institutes of Health	8/03/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$1,216,058	Trans-NIH Recovery Act Research Support This project involves the identification of genes in mice that determine their susceptibility to experimentally induced seizures. Whereas the short term goal of the project involves the identification of seizure susceptibility genes, the longer term goal See details	National Institutes of Health	9/20/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$1,213,643	Trans-NIH Recovery Act Research Support As reported in each ARRA update:The Revised ARRA Aims include Aim 1 of the original application (to compare extinction of limbic activation by seen vs. unseen cocaine cues), and the Exploratory Aim (to examine DA modulating genetics).Aim 2 of the origina See details	National Institutes of Health	8/01/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$1,208,739	Trans-NIH Recovery Act Research Support We propose a partnership between expert large scale sequencing centers and a collaborative network of research labs focused on the genetics of autism to utilize novel high throughput genome sequencing to discover specific genes underlying the significant See details	National Institutes of Health	9/28/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$1,193,272	Trans-NIH Recovery Act Research Support The large ongoing NIH COPDGene® trial is a genome wide association study designed to elucidate the genetic basis of chronic obstructive pulmonary disease (COPD). This study also provides a unique opportunity to rapidly develop plasma biomarkers for C This spending item is part of a $1,576,840 allocation. See details	National Institutes of Health	9/25/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$1,189,504	Trans-NIH Recovery Act Research Support While technologic advances in imaging techniques such as US, CT, and MRI have contributed tremendously to patient care, expenditures related to their use have increased rapidly and significant practice pattern variation exists in imaging utilization. Subs This spending item is part of a $1,500,000 allocation. See details	National Institutes of Health	9/25/2010
TREATMENT RESEARCH INSTITUTE	$1,187,275	Trans-NIH Recovery Act Research Support This two-year NIDA R01 competing-continuation grant extended the work of Dr. Festinger and TRIG??s section on Law & Ethics on improving the ethics of informed consent to participate in research studies. The initial 3-year grant examined the effects of a See details	National Institutes of Health	7/16/2009
Federation Day-Care Services	$1,184,142	ARRA Child Care and Development Block Grant The American Recovery and Reinvestment Act (ARRA) Child Care and Development Fund (CCDF) funds have two mandatory earmarks, Infant/Toddler and Quality. The Infant/Toddler funds are utilized for new center-based Keystone Babies programs. Specifically, th This spending item is part of a $60,146,767 allocation. See details	Administration for Children and Families	4/09/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$1,184,101	Trans-NIH Recovery Act Research Support This project will improve scientists ability to use medical imaging to quantitatively assess the effects of healthydevelopment, aging and disease on the connectivity between different regions of the human brain. Scientificinterest in brain connectivity h See details	National Institutes of Health	9/15/2009
HEALTH FEDERATION OF PHILADELPHIA, THE	$1,174,935	ARRA - Early Head Start Health Federation of Philadelphia Early Head Start (HFP-EHS). This project serves 55 infants and toddlers and 5 pregnant women. Our program is a home based option serving North Philadelphia within the following zip codes: 19121, 19122 (the portion that i See details	Administration for Children and Families	11/18/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$1,164,381	Trans-NIH Recovery Act Research Support It is the over 3,800 chemical components of tobacco smoke, which makes it the leading cause of death in America. Associated with cardiovascular disease, chronic obstructive pulmonary disease, and pancreatic disease, tobacco smoke is responsible for more d See details	National Institutes of Health	5/21/2009
THOMAS JEFFERSON UNIVERSITY	$1,153,635	ARRA Grants for Training in Primary Care Medicine and Dentistry Training and Enhancement This project is the creation, implementation, and evaluation of the Jefferson Interprofessional Primary Care Dual Degree program (IPCDDP). The IPCDDP addresses the critical need to redesign the nation's primary y care system to meet the mandates of the Ins... Show more This spending item is part of a $1,225,039 allocation. See details	Health Resources and Services Administration	8/31/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$1,123,677	Trans-NIH Recovery Act Research Support This project has obtained follow up photography of the fundus of CRIC patients. Analyisis of the photographs has been completed. We will be performing the statistical analysis of the results. This will allow us to investigate the relationship between pro This spending item is part of a $1,464,614 allocation. See details	National Institutes of Health	9/30/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$1,108,818	Trans-NIH Recovery Act Research Support For applications in biodefense, it is desirable for small molecule inhibitors to target multiple category A C agents because it is difficult and expensive to develop even one small molecule inhibitor. We propose to develop inhibitors of Holliday junction This spending item is part of a $1,954,823 allocation. See details	National Institutes of Health	9/01/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$1,100,000	Recovery Act Comparative Effectiveness Research - AHRQ EHRs have the potential to anchor a learning healthcare system where each clinical encounter is an opportunity to learn and to improve clinical outcomes. We propose to link EHRs to disease-specific registries in a distributed network of pediatricic healthca... Show more This spending item is part of a $11,743,165 allocation. See details	Agency for Healthcare Research and Quality	9/28/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$1,059,107	Trans-NIH Recovery Act Research Support Treatment for substance use disorders generally consists of relatively brief episodes of care that do not properly address the chronic, relapsing nature of these disorders. In the parent grant and other prior work, we have developed a telephone based con See details	National Institutes of Health	9/28/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$1,028,088	Trans-NIH Recovery Act Research Support Current clinical periodontal treatment is often not sufficient on its own to control destructive inflammation. This necessitates improved therapeutic approaches, especially in the elderly who are more susceptible to periodontitis. We propose that old age See details	National Institutes of Health	1/10/2012
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$1,018,919	Trans-NIH Recovery Act Research Support Despite a reduction in the incidence of HIV-associated dementia (HAD) in the era of Highly Active Anti-Retroviral Therapy (HAART), the prevalence of HAD is increasing, as is the frequency of minor cognitive diagnoses in HIV-positive patients. Although HA See details	National Institutes of Health	5/05/2009
DREXEL UNIVERSITY	$1,018,829	Trans-NIH Recovery Act Research Support The objective of our research is to develop therapeutic approaches for hypoxic brain damage in the newborn by elucidating cellular and molecular mechanisms of cerebral injury induced by hypoxia and by assessing the efficacy of selective inhibitors for pre See details	National Institutes of Health	8/27/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$1,016,847	Trans-NIH Recovery Act Research Support Secretion is one of the most ubiquitous of cellular processes. Indeed, it is central to such diverse biological functions as information processing, reproduction, motility, temperature regulation, metabolism, the immune response, and signal transduction. See details	National Institutes of Health	7/17/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$1,012,143	Trans-NIH Recovery Act Research Support The sizable weight losses seen with bariatric surgery are often associated with improvements or resolution of several obesity related comorbidities, including type 2 diabetes. The proposed project is designed to investigate the mechanism by which Roux en See details	National Institutes of Health	9/18/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$1,009,381	Trans-NIH Recovery Act Research Support Supplemental funds are requested to study systematically potential differences in the response to COX-2 selective vs non-selective NSAIDs in an approach that integrates (i) quantitative signatures of drug response in cellular and in vivo model systems ? e See details	National Institutes of Health	9/14/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$1,005,496	Trans-NIH Recovery Act Research Support The long-term objective of our research is to characterize the molecular and genetic role of GCM2 in controlling parathyroid gland development during embryogenesis and parathyroid cell maintenance after birth. Studies in mice have shown that parathyroid f See details	National Institutes of Health	7/17/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$1,002,381	Trans-NIH Recovery Act Research Support T cells develop in the thymus from blood cell progenitors. The identity of molecules that allow some blood cell progenitors to migrate to the thymus is unknown. We propose to identify molecules that support trafficking of progenitors to the thymus, to ide See details	National Institutes of Health	9/29/2009
PHILADELPHIA PARENT CHILD CENTER	$1,002,136	ARRA Child Care and Development Block Grant The American Recovery and Reinvestment Act (ARRA) Child Care and Development Fund (CCDF) funds have two mandatory earmarks, Infant/Toddler and Quality. The Infant/Toddler funds are utilized for new center-based Keystone Babies programs. Specifically, th This spending item is part of a $60,146,767 allocation. See details	Administration for Children and Families	4/09/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$1,001,887	Trans-NIH Recovery Act Research Support The goal of this project is to develop software that simplifies the analysis of brain imagedata. We will make all of these software components available from a web accessibleimage database. We expect that, as we implement more components of this softwares See details	National Institutes of Health	8/14/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$1,000,000	Trans-NIH Recovery Act Research Support The investigators will leverage their significant experience with CMS claims and their active participation in three nationwide research networks to compile a very large permanent (yet continually updatable) national data resource for the purposes of comp See details	National Institutes of Health	9/29/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$1,000,000	Trans-NIH Recovery Act Research Support This is a Challenge application submitted in response to an RFP in the ARRA. We proposed to do transformative genome-wide studies of relating circadian transcription factor binding to biological rhythms and metabolic pathways. See details	National Institutes of Health	9/18/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$1,000,000	Trans-NIH Recovery Act Research Support Sleep loss is a major American health problem. The proposed studies will determine a biomarker for sleep loss. We hypothesize there are molecular signatures that reflect the state of sleepiness. See details	National Institutes of Health	9/18/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$1,000,000	Trans-NIH Recovery Act Research Support The advent of new stem cell approaches to cure disease and repair tissue damage is one of the most exciting developments in recent science. Some of the most exciting stem cell technology rests with the ability to reprogram nuclei. The oocyte is uniquely See details	National Institutes of Health	9/29/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$1,000,000	Trans-NIH Recovery Act Research Support Effective and safe delivery of an agent with anti inflammatory, antioxidant and anti fibrotic properties would have clear value in radiation pneumonopathy. Our preliminary data shows robust protection by whole grain flaxseed from radiation induced lung fi See details	National Institutes of Health	6/14/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$999,986	Trans-NIH Recovery Act Research Support The goals of this project are to perform assay related to diabetes, lipid metabolism and coronary disease in the Pakistan Risk of Myocardial Infarction Study (PROMIS). This project will generate novel data regarding the links between T2DM and CHD in Paki See details	National Institutes of Health	9/21/2009
GREATER PHILADELPHIA HEALTH ACTION, INCORPORATED	$999,180	ARRA Health Center Integrated Services Development Initiative[g1] ARRA - Increased Demand for Services (IDS) will allow GPHA to increase service capacity and expand access in the following areas: 1)Comprehensive primary care pediatrics, 2)Preventive and restorative dental services for pediatric patieients from age 1 throu... Show more See details	Health Resources and Services Administration	3/27/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$999,158	Trans-NIH Recovery Act Research Support The calcification of the Aortic Valve represents a multifactor process underling varied associated pathologies. Due to the high prevalence and mortality associated with aortic valve calcification novel biomarkers are constantly needed for an early diagnos See details	National Institutes of Health	9/21/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$998,516	Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area (08) Genomics and specific Challenge Topic, 08-AR-101: Genotyping of Existing Cohorts in Rheumatic, Skin, and Musculoskeletal Diseases. These studies will utilize existing clinical cohorts to create a broadl See details	National Institutes of Health	9/25/2009
THOMAS JEFFERSON UNIVERSITY	$997,134	Trans-NIH Recovery Act Research Support This application addresses Broad Challenge Area (09): Health Disparities and Prevention and Specific Challenge Topic, 09-CA-101: The Basis for Differences in Cancer Incidence. There is an established disparity in stage-specific outcomes in African America See details	National Institutes of Health	9/28/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$996,977	Trans-NIH Recovery Act Research Support This application is intended for the (06) 'Enabling Technologies' challenge area & (06- HG-102*) 'Technologies for obtaining genomic, proteomic, & metabolomic data from individual viable cells in complex tissue' challenge topic. The specialized microenvir See details	National Institutes of Health	9/30/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$995,355	Trans-NIH Recovery Act Research Support Treatment for drug use disorders generally consists of relatively brief episodes of care that do not properly address the chronic, relapsing nature of these disorders. In prior work, we have developed a telephone based adaptive continuing care model that See details	National Institutes of Health	9/21/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$994,267	Trans-NIH Recovery Act Research Support The present proposal seeks to determine the individual and interactive effects of estrogen and serotonin on cognitive processing and brain activation through the addition of functional magnetic resonance imaging (fMRI) to the paradigm of tryptophan deplet See details	National Institutes of Health	9/24/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$991,039	Trans-NIH Recovery Act Research Support This proposal describes the development of a gene regulation system in the context of AAV gene therapy for age related macular degeneration (AMD). AMD is a growing disease and a major cause of visual disability in the aging population with a significant s See details	National Institutes of Health	9/30/2009
WISTAR INSTITUTE OF ANATOMY & BIOLOGY	$990,161	Trans-NIH Recovery Act Research Support This application addresses broad Challenge Areas (15): Translational Science and Specific Challenge Topic 15-HL-102: Develop therapeutic strategies for heart, lung, and blood diseases based on microRNA technology. One type of RNA editing involves the conv See details	National Institutes of Health	9/21/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$988,260	Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area (10) Information Technology for Processing Healthcare Data, 10-LM-102: Advanced decision support for complex clinical decisions. The lack of prescribing information & meaningful dosing guidance places an inc See details	National Institutes of Health	9/24/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$982,256	Trans-NIH Recovery Act Research Support Abstract The effectiveness of anticancer treatment can be compromised by structural or physiological barriers. This is particularly true for the treatment of intracranial malignancies. The grim prognosis associated with these tumors is due in part to t See details	National Institutes of Health	9/29/2009
FOX CHASE CANCER CENTER	$981,011	Trans-NIH Recovery Act Research Support This application addresses Challenge Area (06): Enabling Technologies, and specific Challenge Topic, 06-OD (OBSSR)-101*, Using new technologies to improve or measure adherence, and is entitled G?Preventing postpartum smoking relapse: A C-SHIP based Text M See details	National Institutes of Health	9/29/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$979,923	Trans-NIH Recovery Act Research Support This project will mine text from Internet discussion boards, chat rooms, and blogs to identify possible side effects and adverse4 events associated with the use of herbal supplements in breast and prostate cancer. We will identify sites that support thes See details	National Institutes of Health	9/24/2009
URBAN LEAGUE OF PHILADELPHIA	$978,529	ARRA Child Care and Development Block Grant The American Recovery and Reinvestment Act (ARRA) Child Care and Development Fund (CCDF) funds have two mandatory earmarks, Infant/Toddler and Quality. The Infant/Toddler funds are utilized for new center-based Keystone Babies programs. Specifically, th This spending item is part of a $60,146,767 allocation. See details	Administration for Children and Families	4/09/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$971,768	Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area (05) Comparative Effectiveness Research and Specific Challenge Topic 05 MD105, Health Literacy. After examining feasibility, this intervention compares the use of a patient advocate to promote effective heal This spending item is part of a $1,013,230 allocation. See details	National Institutes of Health	9/18/2009
THE INSTITUTE FOR CANCER RESEARCH	$971,037	Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area (06) Enabling Technologies, and specific Challenge Topic, 06-CA-117: Cancer Development, Pathology, and Pathological Progression. B cell chronic lymphocytic leukemia (CLL) is the most common leukemia affecti See details	National Institutes of Health	9/17/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$965,438	Trans-NIH Recovery Act Research Support The goal of this proposal is to identify auto antigens in new autoimmune encephalopathies in human patients, and to determine the effects of patient auto antibodies on neurons and synapses. The proposal thus has clinical and basic neuroscience components See details	National Institutes of Health	9/29/2009
CARING PEOPLE ALLIANCE	$965,027	ARRA Child Care and Development Block Grant The American Recovery and Reinvestment Act (ARRA) Child Care and Development Fund (CCDF) funds have two mandatory earmarks, Infant/Toddler and Quality. The Infant/Toddler funds are utilized for new center-based Keystone Babies programs. Specifically, th This spending item is part of a $60,146,767 allocation. See details	Administration for Children and Families	4/09/2009
THOMAS JEFFERSON UNIVERSITY	$956,943	Trans-NIH Recovery Act Research Support This New Faculty Supplement provides funding for a new physician-scientist recruit who will expand on her program related to stem cells underlying hepato-billiary tumorigenesis. In this context, the recruit will represent a key new faculty member in our See details	National Institutes of Health	9/24/2009
Trustees of The Unversity of Pennsylvania	$956,936	ARRA - Prevention and Wellness--Communities Putting Prevention to Work This past quarter, PhiladelphiaG??s CPPW was able to make great strides in in completing its main tobacco control objectives. An executive order made 183 recreation centers, playgrounds, and outdoor pools smoke-free, affecting ovever 3.7 million visits. New... Show more This spending item is part of a $10,356,927 allocation. See details	Centers for Disease Control and Prevention	3/19/2010
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$955,749	Trans-NIH Recovery Act Research Support The purpose of this research is to design and synthesize novel Beta-lactam containing compounds to use as chemical probes to better understand the biology of glutamate transporter subtype 1(GLT-1) upon activation by the Beta -lactam antibiotic ceftriaxone See details	National Institutes of Health	9/28/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$951,600	Trans-NIH Recovery Act Research Support PURPOSE: Enhancement of the capabilities of the NURSA to generate and disseminate nuclear receptor and coregulator datasets and methodologies of a more translational character. ABSTRACT: Define the temporal and spatial physiology of Nuclear Receptors This spending item is part of a $3,184,099 allocation. See details	National Institutes of Health	9/21/2009
Trustees of The Unversity of Pennsylvania	$949,844	ARRA - Prevention and Wellness--Communities Putting Prevention to Work PhiladelphiaG??s nutrition and physical activity challenges are daunting: nearly half of children are overweight or obese, low-income communities have little access to healthy foods, and opportunities for physical activity in schohools, neighborhoods, and w... Show more This spending item is part of a $15,018,277 allocation. See details	Centers for Disease Control and Prevention	3/19/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$932,526	Trans-NIH Recovery Act Research Support The overall goal of this study is to develop and validate a novel cell basedhigh throughput, high content, vascular health profile analysis that provides a signature for individualsat high risk for cardiovascular events. A unique biocomputational approach See details	National Institutes of Health	9/21/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$930,571	Trans-NIH Recovery Act Research Support Air pollution, particularly O3, induces exacerbations of asthma that substantially worsen morbidity and mortality. In healthy individuals inhalation of O3 elicits mechanisms such as homeostatic increase in SP D synthesis that protect the lung from develop This spending item is part of a $1,000,000 allocation. See details	National Institutes of Health	9/28/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$926,526	ARRA - Prevention and Wellness--Communities Putting Prevention to Work This past quarter, Philadelphia's CPPW enhanced evaluation team completed follow-up data collection on: 1) corner store environmental assessments in 200 stores, 2) food purchases of 4,000 corner store customers, 3) school environmnmental assessments in 100 ... Show more This spending item is part of a $1,747,143 allocation. See details	Centers for Disease Control and Prevention	9/30/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$926,066	Trans-NIH Recovery Act Research Support This application addresses Broad Challenge Area (09): Health Disparities and the Specific Challenge Topic, 09 MD 103: Initiating Innovative Interventions to Prevent Family Violence. We are engaged in the large scale demonstration project evaluating the This spending item is part of a $999,990 allocation. See details	National Institutes of Health	9/24/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$915,449	Trans-NIH Recovery Act Research Support The goal of this project is to develop a gene therapeutic for retinitis pigmentosa (RP). RP is the most common inherited form of blindness, and is characterized by photoreceptor loss, leading to a progressive loss of peripheral as well as night vision. This spending item is part of a $2,822,695 allocation. See details	National Institutes of Health	7/26/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$907,262	Trans-NIH Recovery Act Research Support Vascular gas embolism contributes to cerebral dysfunction in over 300,000 cardiopulmonary bypass patients in the US annually. Transient and permanent brain abnormalities occur. These include reduced cognitive function, speech and speech processing impairm See details	National Institutes of Health	6/01/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$902,153	Trans-NIH Recovery Act Research Support Despite the major public health impact, the etiologies of refractive errors generally and myopia in particular are poorly understood. We are conducting an innovative approach to evaluate altered gene expression in eyes of chicks developing refractive erro See details	National Institutes of Health	7/17/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$901,214	Trans-NIH Recovery Act Research Support This application will investigate how the transcriptional coactivator, Myocardin, regulates the differentiated state of the heart and the capacity of the heart to respond to hemodynamic stress. We have generated genetically altered mice with cardiac restr See details	National Institutes of Health	6/01/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$889,633	Trans-NIH Recovery Act Research Support Anionic polymers such as F actin and DNA found in the airway fluid of cystic fibrosis (CF) patients and other infected sites are strong inhibitors of endogenous cationic antimicrobial peptides such as those produced at the airway epithelium. This revised See details	National Institutes of Health	5/30/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$867,742	Trans-NIH Recovery Act Research Support Our goal is to determine the clinical, cognitive, imaging, genetic, and biochemical biomarker characteristics of the early (pre-dementia) stages of Alzheimer's disease (AD). The project builds on the NIA-funded AD Neuroimaging Initiative (ADNI1) and serve This spending item is part of a $23,822,294 allocation. See details	National Institutes of Health	9/24/2009
THOMAS JEFFERSON UNIVERSITY	$867,620	Trans-NIH Recovery Act Research Support Since recent studies suggest that environmental toxicants can affect the integrity of the genome through effects on epigenetic mechanisms, the extent to which this occurs with different levels and types of Pb exposure need to be studied. Thus, the researc See details	National Institutes of Health	9/23/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$867,477	Trans-NIH Recovery Act Research Support Specific Aims: Acute Lung Injury (ALI) is a common complication of sepsis and trauma and is associated with mortality of over 20%. Candidate gene studies suggest a role for common genetic variation in determining host susceptibility to ALI in critically This spending item is part of a $4,676,664 allocation. See details	National Institutes of Health	9/25/2009
THE INSTITUTE FOR CANCER RESEARCH	$866,366	Trans-NIH Recovery Act Research Support Title: Molecular Triggers of T Helper Lineage Choice Abstract: Differentiation of thymocytes into alternate T killer and helper lineages is of great interest, due to its importance in shaping the T cell compartment and as a paradigm of binary lineage deci See details	National Institutes of Health	5/21/2009
THE INSTITUTE FOR CANCER RESEARCH	$866,336	Trans-NIH Recovery Act Research Support Abstract: Differentiation of thymocytes into alternate T killer and helper lineages is of great interest, due to its importance in shaping the T cell compartment and as a paradigm of binary lineage decisions. Recently, the transcription factor Zbtb7b has See details	National Institutes of Health	5/21/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$862,016	Trans-NIH Recovery Act Research Support There is currently no sensitive noninvasive method for diagnosing preclinical peripheral arterial disease (PAD), which affects 8 million Americans. In this project we propose to implement and evaluate a new noninvasive MRI based method in healthy subjects This spending item is part of a $907,193 allocation. See details	National Institutes of Health	9/21/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$857,577	Trans-NIH Recovery Act Research Support We propose to test the hypothesis that mitochondrial dysfunction is an important factor in the etiology of autism spectrum disorders (ASD). The mitochondria play four central roles in cell and tissue function: they provide most of the energy, generate muc See details	National Institutes of Health	9/10/2010
THOMAS JEFFERSON UNIVERSITY	$849,750	Trans-NIH Recovery Act Research Support In the previous funding cycle, we have found that EAAT2 is selectively cleaved by caspase-3 in the spinal cord of mutant SOD1 (SOD1-G93A) transgenic mice model of ALS and that the C-terminal EAAT2 fragment derived from this cleavage (termed CTE fragment) See details	National Institutes of Health	8/04/2009
TREATMENT RESEARCH INSTITUTE	$847,194	Trans-NIH Recovery Act Research Support There are well documented problems in adapting evidence-based treatments (EBT's) to fit the real world of addiction treatment programs - most EBT's are too complex and require too much training and ongoing clinical supervision to be practical for communit See details	National Institutes of Health	6/05/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$845,947	Trans-NIH Recovery Act Research Support We propose to undertake an empirical investigation of the predictive validity of CBC in the clinical context of racial ethnic disparities in analgesic preference and adherence to prescription analgesia for cancer pain. Data derived from this study will la See details	National Institutes of Health	9/24/2009
QUALITY COMMUNITY HEALTH CARE, INC.	$841,465	ARRA Health Center Integrated Services Development Initiative[g1] The Capital Improvement Program has provided funds which enable this organization to address its needs and reach its goals to better serve our patients via:alterations/repairs/renovations in our existing facility; improve our ability t to address the needs ... Show more See details	Health Resources and Services Administration	6/25/2009
THOMAS JEFFERSON UNIVERSITY	$834,662	Trans-NIH Recovery Act Research Support This application addresses the broad Challenge Area (05) Comparative Effectiveness Research and specific Challenge Topic, 05-MH-102*: Cost Effectiveness of Mental Health Interventions. We propose a two year initiative to add a cost and outcome component This spending item is part of a $997,110 allocation. See details	National Institutes of Health	9/29/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$831,540	Trans-NIH Recovery Act Research Support We propose to tackle the challenge (06-HL-103) of providing enabling technologies directed towards developing novel quantitative imaging approaches for the measurement of coagulation enzyme function in the intact mouse to improve basic understanding of ce See details	National Institutes of Health	9/28/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$831,438	Trans-NIH Recovery Act Research Support Transcription factor GATA-1 is critical for the development of multiple blood lineages, including erythroid cells, megakaryocytes, mast cells and eosinophils. Mutations in the Gata1 gene underlie a variety of congenital and acquired hematological disorder See details	National Institutes of Health	8/17/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$822,567	Trans-NIH Recovery Act Research Support Premature infants are a vulnerable population with multiple inter-related health problems that put them at risk for poor outcomes. Electronic health records capture large amounts of information that may help guide decisions, but existing alert and remind See details	National Institutes of Health	8/01/2010
CHILDRENS HOSPITAL OF PHILADELPHIA	$822,500	Trans-NIH Recovery Act Research Support The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a multifunctional protein that transports chloride across the apical plasma membrane of epithelial cells. CFTR also regulates ion transport by other proteins, such as the Epithelial Sodium See details	National Institutes of Health	6/02/2009
THE CHILDREN'S HOSPITAL OF PHILADELPHIA	$820,936	Trans-NIH Recovery Act Research Support This is a competitive supplement in response to NOT-OD-09-058 (NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications). Diabetes is a metabolic disorder that currently affects over 180 million people worldwide. Common t See details	National Institutes of Health	9/30/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$809,502	Trans-NIH Recovery Act Research Support The long-term goals are to comprehensively characterize extraocular muscles (EOMs) at the molecular level. Precise functioning of EOMs is an absolute requirement for optimal vision in humans. EOMs are highly specialized and undergo a wide range of reflexe See details	National Institutes of Health	7/20/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$807,242	Trans-NIH Recovery Act Research Support Melanoma, the most virulent form of skin cancer, is not responsive to chemotherapy. This project proposes to develop a method to sensitize melanomas to chemotherapy by selectively acidifying the cancer cells whileminimally affecting normal cells. The meth This spending item is part of a $937,439 allocation. See details	National Institutes of Health	5/21/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$804,917	Trans-NIH Recovery Act Research Support Completing the Aims of this P30 Neurodegenerative Disease Core Center will build further the multidisciplinary community of neurodegenerative disease researchers at PENN by recruiting two new faculty members whose expertise complements existing PENN progr See details	National Institutes of Health	9/17/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$800,181	Trans-NIH Recovery Act Research Support Tooth loss remains a major health problem in the USA, with up to 40% of residents affected in some regions as a result of dental caries, periodontal disease, trauma, bone loss, or aging. Dental implants are the current state of the art treatment for missi See details	National Institutes of Health	9/22/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$793,500	Trans-NIH Recovery Act Research Support Our long term goal is to understand the role of the basonuclin gene in skin and hair follicle biology. Basonuclin (BNC1) is a zinc finger protein found in abundance in the keratinocytes of the epidermis and hair follicle. We believe that it coordinates ac See details	National Institutes of Health	8/10/2009
CARING PEOPLE ALLIANCE	$790,865	ARRA Child Care and Development Block Grant The American Recovery and Reinvestment Act (ARRA) Child Care and Development Fund (CCDF) funds have two mandatory earmarks, Infant/Toddler and Quality. The Infant/Toddler funds are utilized for new center-based Keystone Babies programs. Specifically, th This spending item is part of a $60,146,767 allocation. See details	Administration for Children and Families	4/09/2009
AMERICAN COLLEGE OF RADIOLOGY, THE	$789,614	Trans-NIH Recovery Act Research Support This award is intended to facilitate accrual to RTOG 0539, 'A Phase II Trial of Observation for Low-risk Meningiomas and of Radiotherapy for Intermediate- and High-risk Meningiomas.' The awarded funds will be used to speed protocol development and activa See details	National Institutes of Health	7/31/2009
THE INSTITUTE FOR CANCER RESEARCH	$787,981	Trans-NIH Recovery Act Research Support Abstract: The objective of this proposal is to understand the mechanism for the 5G?? strand-specific end processing of DNA double-strand breaks (DSBs) in eukaryotes. DSBs are among the most deleterious types of DNA damages. If not properly repaired, DSBs See details	National Institutes of Health	7/17/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$787,500	Trans-NIH Recovery Act Research Support The proposed studies will not only help elucidate the pathogenic mechanisms of autoimmune encephalomyelitis but also aid in developing specific strategies targeting c Rel for the treatment of multiple sclerosis. See details	National Institutes of Health	5/06/2009
THOMAS JEFFERSON UNIVERSITY	$772,500	Trans-NIH Recovery Act Research Support Accumulating evidence has indicated that human immunodeficiency virus type 1 (HIV-1) replication is regulated by cell- or virus-derived miRNAs. Recently, we have found that several cellular miRNAs are involved in establishing and maintaining HIV-1 latency See details	National Institutes of Health	5/21/2009
THOMAS JEFFERSON UNIVERSITY	$772,500	Trans-NIH Recovery Act Research Support ?1-adrenergic receptors (?1ARs) generally do not couple to the adenylyl cyclase inhibitory heterotrimeric G protein, Gi, however, data in cultured cells indicate that phosphorylation of ?1ARs by GRK5 can allow for Gi-coupling due to GRK5 actions causing a See details	National Institutes of Health	6/01/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$762,608	Trans-NIH Recovery Act Research Support To carry out their immunological function, lymphocytes must travel to specific locations within the body. The homing of lymphocyte sublines is controlled through a complex molecular zipcoding, in which surface receptors on lymphocytes bind ligands on bloo See details	National Institutes of Health	7/17/2009
THOMAS JEFFERSON UNIVERSITY	$760,510	Trans-NIH Recovery Act Research Support The long-term goal of this project is to shed light on the molecular mechanisms that govern the function and regulation of the neuronal somatodendritic A-type potassium current (Isa). Typically, Isa operates in the subthreshold range of membrance potentia See details	National Institutes of Health	6/15/2009
WISTAR INSTITUTE OF ANATOMY & BIOLOGY	$756,593	Trans-NIH Recovery Act Research Support The overall goal of this application is to discover and validate multiple novel plasma protein biomarkers of human ovarian cancer. We will initially discover a substantial number of candidate biomarkers through parallel analysis of two complementary model This spending item is part of a $993,896 allocation. See details	National Institutes of Health	6/29/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$756,579	ITKv4 Project Title: Fundamental Refactoring of Deformable Image Registration in ITK with Distributed Computing and GPU Acceleration See details	National Institutes of Health	6/21/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$755,649	Trans-NIH Recovery Act Research Support The spread or metastasis of tumor cells to the lymph nodes of patients with oral cancer is the leading cause of treatment failure and death in this disease. An accurate and reliable clinical test to detect lymph metastasis in oral cancer patients will be This spending item is part of a $777,139 allocation. See details	National Institutes of Health	7/20/2009
AMERICAN COLLEGE OF RADIOLOGY, THE	$750,000	Trans-NIH Recovery Act Research Support American College of Radiology Imaging Network (ACRIN) 6684: Multicenter phase II assessment of tumor hypoxia in glioblastoma using 18F-flouromisonidazole (FMISO) with PET and MRI. This trial will use PET and MRI techniques hand in hand to monitor the sta See details	National Institutes of Health	7/30/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$749,774	Trans-NIH Recovery Act Research Support Routine use of mediated and interpersonal sources provides a substantial amount of information relevant to cancer prevention (e.g. exercise, fruit and vegetable consumption) and screening (e.g. mammography, colon cancer screening, PSA). The issue is whet See details	National Institutes of Health	8/31/2009
THOMAS JEFFERSON UNIVERSITY	$742,525	Trans-NIH Recovery Act Research Support In the dopaminergic neurons, free dopamine in the cytosol is a unique source of endogenous toxins leading to neuron death; however, dopamine of physiological concentration is not sufficient to cause cell death. Dopamine may become toxic when other risk fa See details	National Institutes of Health	7/27/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$740,250	Trans-NIH Recovery Act Research Support Cell migration is fundamental to normal central nervous system (CNS) development and perturbations in this process have been implicated in the pathogenesis of many neurologic disorders including epilepsy, mental retardation and autism. Understanding the p See details	National Institutes of Health	8/20/2009
Bicycle Coalition of Delaware Valley Inc	$735,991	ARRA - Prevention and Wellness--Communities Putting Prevention to Work PhiladelphiaG??s nutrition and physical activity challenges are daunting: nearly half of children are overweight or obese, low-income communities have little access to healthy foods, and opportunities for physical activity in schohools, neighborhoods, and w... Show more This spending item is part of a $15,018,277 allocation. See details	Centers for Disease Control and Prevention	3/19/2010
RESOURCES FOR HUMAN DEVELOPMENT, INC.	$735,590	ARRA Health Center Integrated Services Development Initiative[g1] ARRA - Capital Improvement See details	Health Resources and Services Administration	6/25/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$735,043	Recovery Act Comparative Effectiveness Research - AHRQ For Stage I Part 1, we extracted limited access data sets from APPLES including 106 data terms for which a data dictionary could be provided. These data were then used to enable, evaluate, and refine tools previously developed during the NCRR-supupported Ph... Show more This spending item is part of a $8,309,936 allocation. See details	Agency for Healthcare Research and Quality	9/28/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$730,269	Trans-NIH Recovery Act Research Support Comparative effectiveness research (CER) primarily involves estimation of causal effects of alternativetreatments on outcomes. To this end, observational databases are a promising source of information onpatient-level treatments and outcomes. However, obs This spending item is part of a $1,453,104 allocation. See details	National Institutes of Health	8/01/2011
PHILADELPHIA PARENT CHILD CENTER	$722,326	ARRA Child Care and Development Block Grant The American Recovery and Reinvestment Act (ARRA) Child Care and Development Fund (CCDF) funds have two mandatory earmarks, Infant/Toddler and Quality. The Infant/Toddler funds are utilized for new center-based Keystone Babies programs. Specifically, th This spending item is part of a $60,146,767 allocation. See details	Administration for Children and Families	4/09/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$718,977	Trans-NIH Recovery Act Research Support This application addresses the broad Challenge area (06) Enabling Technologies, and the specific Challenge Topic, 06 EB 109: Model Driven Biomedical Technology Development. The objective of this proposal is to develop an image based disc model that incor This spending item is part of a $999,996 allocation. See details	National Institutes of Health	9/21/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$710,982	Trans-NIH Recovery Act Research Support Endochondral bone formation is a complex process in which mesenchymal cells initially differentiate into chondrocytes, giving rise to cartilage elements that form templates for most of the skeleton. This process is regulated by several important hormones See details	National Institutes of Health	7/17/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$709,283	Trans-NIH Recovery Act Research Support The Children's Hospital of Philadelphia (CHOP) contributes substantially to the local economy. In 2008, CHOP's operations created and supported over 16,882 jobs in the region, and CHOP's total economic impact was over $5.9 billion. Moreover, through a com This spending item is part of a $958,961 allocation. See details	National Institutes of Health	9/30/2009
PUBLIC HEALTH MANAGEMENT CORPORATION	$700,000	ARRA - Immunization The Philadelphia Department of Public Health (PDPH) Immunization Program has operated an Immunization Information System (IIS) known as KIDS since 1993. KIDS informs over 1,000 health care providers in the city about required and missing immunizations fo This spending item is part of a $912,733 allocation. See details	Centers for Disease Control and Prevention	9/01/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$696,150	Trans-NIH Recovery Act Research Support This supplement will expand co investigator, project management, analytical and laboratory activities to accelerate key goals of the CRIC study. It will hasten scientific contributions owing to the immediate availability of a vast array of high quality re See details	National Institutes of Health	9/21/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$685,774	Trans-NIH Recovery Act Research Support The project will develop a standardized Impairment Activity Staging System which specifies the medical impairment perceived by an individual or close proxy to be limiting his or her ability to perform daily activities, and then stages patients by severity See details	National Institutes of Health	8/14/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$682,241	Trans-NIH Recovery Act Research Support This application responds to broad challenge grant area (04): Clinical Research & specific Challenge Topic, 04-MD-101: Enhancing Recruitment & Retention of Ethnic Minorities in Clinical Trials. Sickle cell disease (SCD) is a genetic disorder affecting pri This spending item is part of a $812,955 allocation. See details	National Institutes of Health	9/24/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$676,326	Trans-NIH Recovery Act Research Support This project seeks to understand the basis of keloid formation, a form of disordered wound healing. In keloids, low oxygen tension and collagen deposition are both present, and we will investigate how low oxygen tension directly influences the biosynthes See details	National Institutes of Health	9/28/2009
COALITION OF CANCER COOPERATIVE GROUPS	$674,869	Trans-NIH Recovery Act Research Support The CALGB is comprised of 26 academic medical centers and over 200 affiliated community hospitals joined in the pursuit of improved cancer treatment and better understanding of tumor biology and cancer treatment outcomes via the conduct of controlled clin See details	National Institutes of Health	7/26/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$669,831	Trans-NIH Recovery Act Research Support Each year, novel strains of influenza A virus arise through mutation and manage to infect one-fifth of the human population. We remain woefully ignorant of what specific features determine the success or failure of these antigenic drift variants. As a res See details	National Institutes of Health	9/21/2009
WISTAR INSTITUTE OF ANATOMY & BIOLOGY	$661,982	Trans-NIH Recovery Act Research Support This project addresses 3D or virtual models to reduce the use of animals in research: Creation of miniature multi-cellular organs for high-throughput screening for chemical toxicity testing. Our long-term objective is to decrease the use of animals for to This spending item is part of a $959,491 allocation. See details	National Institutes of Health	9/21/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$660,802	ARRA - Prevention and Wellness--Communities Putting Prevention to Work This past quarter, Philadelphia's CPPW enhanced evaluation team completed follow-up data collection on: 1) corner store environmental assessments in 200 stores, 2) food purchases of 4,000 corner store customers, 3) school environmnmental assessments in 100 ... Show more This spending item is part of a $1,747,143 allocation. See details	Centers for Disease Control and Prevention	9/30/2010
MONELL CHEMICAL SENSES CENTER	$659,349	Trans-NIH Recovery Act Research Support Funds were requested to accelerate research in the Projects of the Monell-Jefferson Chemosensory Clinical Research Center (CCRC) through the retention and hiring of highly skilled individuals and the continuation and expansion of patient recruitment effor See details	National Institutes of Health	7/15/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$657,128	Trans-NIH Recovery Act Research Support Molecules essential for tumor growth and development represent promising targets for novel immunotherapy of cancer, yet host immunosuppressive factors impose major challenges for translating this hypothesis into clinical success. This proposal addresses t See details	National Institutes of Health	7/16/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$650,000	Trans-NIH Recovery Act Research Support In response to partial outlet obstruction, the urinary bladder is capable of undergoing hypertrophy via a complex remodeling process that allows it to adapt to its new workload. This remodeling is driven by a number of signaling cascades and their corresp See details	National Institutes of Health	9/30/2009
SPECTRUM HEALTH SERVICES, INC.	$641,440	ARRA Health Center Integrated Services Development Initiative[g1] Spectrum Health Services proposed three major projects in response to the Capital Improvement Program initiative. The first project is an Alteration/Repair/Renovation project in which Spectrum proposes to use the CIP funds to make rerenovations/ alteratio... Show more See details	Health Resources and Services Administration	6/25/2009
THOMAS JEFFERSON UNIVERSITY	$641,176	Trans-NIH Recovery Act Research Support Aim 1. Determine the mechanisms governing DACH1/Eya inhibition of breast tumor cellular proliferation. We will determine the DACH1 binding proteins governing breast tumor growth we will characterize these components in human breast cancer and investigate See details	National Institutes of Health	7/20/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$640,558	Trans-NIH Recovery Act Research Support The parent grant continues to have three aims. The first is to elucidate how the molecular chaperones BiP and GRP94 react to misfolded Ig in the cell and how this interaction can be employed to reduce the aggregation that leads to amyloid formation. Aim See details	National Institutes of Health	9/29/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$639,666	Trans-NIH Recovery Act Research Support In this proposal we will characterize a novel signaling pathway activated by the growth factor heregulin (HRG) that involves the small G protein Rac1 and its activator P Rex1. Rac1 and P Rex1 mediate mitogenic and motile signals induced by HRG. The goal i See details	National Institutes of Health	6/04/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$637,233	Trans-NIH Recovery Act Research Support Epstein Barr virus nuclear antigen EBNA3C is a latent viral nuclear antigen essential for B cell transformation in vitro. This EBV antigen has been linked to the specific regulation of a number of cellular events which include regulation of transcription, See details	National Institutes of Health	7/16/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$635,965	Trans-NIH Recovery Act Research Support On behalf of the Reproductive Medicine Network (RMN), we, as the Data Coordination Center, submit this request in response to NIH announcement NOT-OD-09-056 for a Recovery Act administrative supplement. We will use the supplement to field a comparative ef This spending item is part of a $7,565,277 allocation. See details	National Institutes of Health	9/30/2009
PUBLIC HEALTH MANAGEMENT CORPORATION	$635,735	ARRA Health Center Integrated Services Development Initiative[g1] PHMC received a Capital Improvement Project award for its 4 health centers, consisting of 3 projects. The first project is the renovation of our Mary Howard Health Center. We will increase the health center from 3,000 square feet to o 6,000 square feet, a... Show more See details	Health Resources and Services Administration	6/25/2009
THOMAS JEFFERSON UNIVERSITY	$633,450	Trans-NIH Recovery Act Research Support Sensitization of IP3R/RyR-mediated Ca2+ release may cause a shift from the physiological to the pathophysiological range of mitochondrial calcium signaling and that a variety of mutations associated with human skeletal (malignant hyperthermia) and cardiac See details	National Institutes of Health	8/14/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$632,809	Trans-NIH Recovery Act Research Support The Ras stimulated Raf MEK ERK kinase cascade is used over and over again to control many aspects of animal development, including tube formation. How this common signaling cascade elicits specific responses is still poorly understood. ERK is thought to p See details	National Institutes of Health	9/25/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$630,000	Trans-NIH Recovery Act Research Support BK-type calcium-activated potassium channels serve as cytoplasmic Ca2+ detectors that can rapidly respond to and modulate transmembrane voltage. These channels are critical in controlling action potential firing in neurons as well as smooth muscle contrac See details	National Institutes of Health	9/16/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$630,000	Trans-NIH Recovery Act Research Support Hepatitis C virus (HCV) is an important human pathogen with a high rate of persistence that can lead to liver cirrhosis and cancer. Given the relevance of T cells in HCV pathogenesis and emerging literature on immune function and exhaustion, we hypothesiz See details	National Institutes of Health	5/21/2009
OPPORTUNITIES INDUSTRIALIZATION CENTERS OF AMERICA, INC.	$629,000	ARRA Strengthening Communities Fund This award is made to organizations with experience in capacity building and requires that they act as a lead organization for the project in a geographic service area which is at or below poverty level. Under this award, lead grantees select nonprofit o This spending item is part of a $1,000,000 allocation. See details	Administration for Children and Families	9/21/2009
THOMAS JEFFERSON UNIVERSITY	$622,356	Trans-NIH Recovery Act Research Support The BCR/ABL oncoproteins, the leukemia-specific gene products of the Philadelphia chromosome (Ph1) translocation, induce and maintain the leukemic phenotype through their deregulated tyrosine kinase activity; such activity is essential for recruitment and See details	National Institutes of Health	7/17/2009
DREXEL UNIVERSITY	$616,530	Trans-NIH Recovery Act Research Support Localization of mRNAs with subsequent translation into new proteins provides a means to geographically regulate neuronal protein composition in distinct subcellular regions. In axons, this localized protein synthesis is needed for growth cone guidance an This spending item is part of a $653,804 allocation. See details	National Institutes of Health	7/15/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$607,827	Trans-NIH Recovery Act Research Support This administrative supplement application proposes the development of an innovative clinical trialscurriculum (CTC) designed to enhance the research training, education, and career development componentof the University of Pennsylvania s (Penn) Clinical See details	National Institutes of Health	9/17/2009
THOMAS JEFFERSON UNIVERSITY	$598,796	Trans-NIH Recovery Act Research Support Infection associated with allograft transplantation and prosthesis use can occur in any patient, and is particularly prevalent and challenging in immunocompromised individuals. When developed, infection can lead to prolonged disability with immense psycho This spending item is part of a $875,280 allocation. See details	National Institutes of Health	9/17/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$595,759	Trans-NIH Recovery Act Research Support Previous studies revealed that certain integrins expressed on endothelial cells play a significant role in the progression of angiogenesis and are an attractive target for the development of angiostatic drugs that may have an application in the therapy of See details	National Institutes of Health	7/17/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$592,297	Trans-NIH Recovery Act Research Support In this proposal we will characterize a member of the family of phorbol ester receptors, protein kinase C epsilon (PKC), and its involvement in prostate carcinogenesis. In the previous funding period we have established that phorbol esters, natural compou This spending item is part of a $631,497 allocation. See details	National Institutes of Health	7/16/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$588,582	Trans-NIH Recovery Act Research Support 1)It will allow us to enhance our ability to detect associations of genetic variants with susceptibility to having mutations in RB1 gene and cause RB disease. 2)Will allow us to hire additional personnel and train them in the current state of the art tech See details	National Institutes of Health	9/15/2009
HEALTH PROMOTION COUNCIL OF SOUTHEASTERN PENNSYLVANIA, INC.	$579,112	ARRA - Prevention and Wellness--Communities Putting Prevention to Work This past quarter, PhiladelphiaG??s CPPW was able to make great strides in in completing its main tobacco control objectives. An executive order made 183 recreation centers, playgrounds, and outdoor pools smoke-free, affecting ovever 3.7 million visits. New... Show more This spending item is part of a $10,356,927 allocation. See details	Centers for Disease Control and Prevention	3/19/2010
THOMAS JEFFERSON UNIVERSITY	$569,949	Trans-NIH Recovery Act Research Support Common complications of portal hypertension include gastroesophageal varices, ascites, and portasystemic encephalopathy. Patients with cirrhosis have a 5-10% yearly incidence of variceal formation, and a 4-15% yearly incidence of bleeding. Each bleeding e This spending item is part of a $894,942 allocation. See details	National Institutes of Health	9/29/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$569,212	Trans-NIH Recovery Act Research Support The proposed research will study a novel approach for treating heart valve disease via the use of heart valve replacements with trileaflet polyurethane prostheses that are endothelial seeded using blood outgrowth endothelial cells (BOEC). We will investig This spending item is part of a $958,249 allocation. See details	National Institutes of Health	7/16/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$567,970	Trans-NIH Recovery Act Research Support This is a translational research study of the role of glucagon-like peptide-1 (GLP-1) in congenital hyperinsulinism (CHI), the most frequent cause of persistent hypoglycemia in children. CHI is a genetic disorder of pancreatic ?-?-cell function characteri See details	National Institutes of Health	8/10/2009
WISTAR INSTITUTE OF ANATOMY & BIOLOGY	$563,518	Trans-NIH Recovery Act Research Support The effect of innate cellular activation on HIV transmission efficiency, absent inflammation of the genital mucosa associated with active co-infections, remains unknown. Although some early attempts at answering this question have been tried, recent resul This spending item is part of a $1,558,403 allocation. See details	National Institutes of Health	9/11/2009
DELAWARE VALLEY COMMUNITY HEALTH, INC.	$556,770	ARRA Health Center Integrated Services Development Initiative[g1] Through this IDS project, Delaware Valley Community Heath (DVCH) will first recruit a mid-level provider and pediatrician for Maria de los Santos Health Center (MDLS). This relocated center was opened in 2008 and has physical capacityty for more providers ... Show more See details	Health Resources and Services Administration	3/27/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$544,149	Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area (15) Translational Science, Gene x environment x development (GxExD) studies of brain function & mental disorders. Gene x environment epidemiology & psychiatry research studies have only recently been used & This spending item is part of a $949,431 allocation. See details	National Institutes of Health	9/24/2009
MONELL CHEMICAL SENSES CENTER	$543,211	Trans-NIH Recovery Act Research Support During the past few years my laboratory has explored the involvement of taste signaling elements in gastrointestinal (GI) chemosensation. In particular, how macronutrients in the gut lumen are sensed and in turn regulate hormone release from specific ente See details	National Institutes of Health	7/31/2009
DREXEL UNIVERSITY	$536,958	Trans-NIH Recovery Act Research Support The echinocandins (ECs) are a new antifungal group that includes caspofungin, micafungin, and anidulafungin. ECs represent a profoundly important development in antifungal chemotherapy because they are generally fungicidal, non-toxic, and remain active v See details	National Institutes of Health	6/01/2009
CARING PEOPLE ALLIANCE	$533,633	ARRA Child Care and Development Block Grant The American Recovery and Reinvestment Act (ARRA) Child Care and Development Fund (CCDF) funds have two mandatory earmarks, Infant/Toddler and Quality. The Infant/Toddler funds are utilized for new center-based Keystone Babies programs. Specifically, th This spending item is part of a $60,146,767 allocation. See details	Administration for Children and Families	4/09/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$532,326	Trans-NIH Recovery Act Research Support This is a competitive supplement in response to NOT-OD-09-058 (NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications). Diabetes is a metabolic disorder that currently affects over 180 million people worldwide. Common t This spending item is part of a $820,936 allocation. See details	National Institutes of Health	9/30/2009
COVENANT HOUSE INC	$530,000	ARRA Health Center Integrated Services Development Initiative[g1] The CIP funds has allowed CHI to purchase and install a new health information system and a dental clinic at 138 W. Chelten Avenue. Covenant House Inc. has also remodeled the patient waiting area at 251 Bringhurst, established a Behavavorial Health area an... Show more See details	Health Resources and Services Administration	6/25/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$528,865	Trans-NIH Recovery Act Research Support This proposal will provide information essential to informing treatment decisions for patients with psoriasis and future, longitudinal comparative effectiveness studies. Ultimately, this line of research will lead to more rationale treatment decisions and This spending item is part of a $1,000,000 allocation. See details	National Institutes of Health	9/24/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$526,815	Trans-NIH Recovery Act Research Support With this award our goal is to use biomarkers of platelet factor 4 (PF4), platelet activation and immune response, along with clinical factors to identify patients at risk of heparin/PF4 antibody formation. Patients who undergo surgery requiring cardiopu This spending item is part of a $996,583 allocation. See details	National Institutes of Health	11/25/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$523,445	Trans-NIH Recovery Act Research Support The long-range goal of this Program Project is to develop therapeutic strategies that ameliorate muscle atrophy and augment muscle rehabilitation following pathological conditions such as spinal cord injury. Muscle atrophy or loss of muscle mass is a per This spending item is part of a $2,298,355 allocation. See details	National Institutes of Health	9/30/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$521,952	Trans-NIH Recovery Act Research Support Schizophrenia is a common, profoundly disabling disorder that carries a heavy burden for patients and families that is the subject of intensive genetic studies, but the study of epigenetic variation, such as DNA methylation, is an essential complement to See details	National Institutes of Health	9/30/2009
COALITION OF CANCER COOPERATIVE GROUPS	$520,363	Trans-NIH Recovery Act Research Support The CALGB is comprised of 26 academic medical centers and over 200 affiliated community hospitals joined in the pursuit of improved cancer treatment and better understanding of tumor biology and cancer treatment outcomes via the conduct of controlled clin This spending item is part of a $598,637 allocation. See details	National Institutes of Health	7/26/2010
WISTAR INSTITUTE OF ANATOMY & BIOLOGY	$515,049	Trans-NIH Recovery Act Research Support The long-term goal of the proposal this administrative supplement supports is to study the effects of early antiretroviral therapy (ART) in HIV-infected infants and the functional reconstitution/maturation of antiviral effector mechanisms of the innate/ad See details	National Institutes of Health	5/17/2010
PUBLIC HEALTH MANAGEMENT CORPORATION	$512,217	ARRA - Immunization Two main Immunization areas will be the focus of the Philadelphia Department of Public HealthG??s (PDPH) project - the Vaccines for Adults At Risk Program (VFAAR) and the KIDS Registry. Utilizing funds awarded through the ARRA Supplemental Funding for Rea This spending item is part of a $564,358 allocation. See details	Centers for Disease Control and Prevention	9/15/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$508,178	Trans-NIH Recovery Act Research Support These investigations will further define potential roles for new visual function tests and ocular imaging measures as potential outcomes for MS clinical trials, and will apply paradigms from MS vision research to acute ON as a more specific model for asse This spending item is part of a $1,296,171 allocation. See details	National Institutes of Health	6/03/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$505,935	Trans-NIH Recovery Act Research Support Our overarching goals are to design better therapies for the treatment of brain tumors. Medulloblastoma, a pediatric malignancy of the cerebellum with the highest incidence of all pediatric brain tumors, and glioma, themost malignant and invasive adult br This spending item is part of a $853,079 allocation. See details	National Institutes of Health	7/16/2009
TREATMENT RESEARCH INSTITUTE	$505,327	Trans-NIH Recovery Act Research Support According to national epidemiologic surveillance systems (i.e., Monitoring the Future, the National Survey on Drug Use and Health), adolescent nonmedical use of highly addictive prescription opioid analgesic drugs (e.g., Vicodin-?, Oxycontin-?) and tranqu This spending item is part of a $953,273 allocation. See details	National Institutes of Health	8/31/2009
ALBERT EINSTEIN HEALTHCARE NETWORK	$504,571	The Cancer Human Biobank (caHUB) - This is a national, standardized , biospecimen resource for the collection of human tissues which are a critical resource for cancer research. Contracts will be established with medical research adn healthcare entities This spending item is part of a $60,000,000 allocation. See details	National Institutes of Health	9/04/2009
DREXEL UNIVERSITY	$500,000	Trans-NIH Recovery Act Research Support The objective of this project is to enhance current and future research productivity and to remain in compliance with Federal regulations for the care and use of research animals at the Center City campus of Drexel University College of Medicine. The New See details	National Institutes of Health	7/16/2009
INTEGRAL MOLECULAR, INC	$500,000	Trans-NIH Recovery Act Research Support Influenza virus is a Category C biodefense pathogen of global public health concern because it causes 3-5 million cases of severe illness every year, and because of the potential for the emergence of new, highly pathogenic strains that could cause pandemi See details	National Institutes of Health	8/28/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$500,000	Trans-NIH Recovery Act Research Support The proposed upgrade of the 7 Tesla imaging resource will substantially impact the fundamental understanding, early diagnosis, and development of novel therapies for host of human disease. See details	National Institutes of Health	2/01/2010
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$500,000	Trans-NIH Recovery Act Research Support Multiphoton microscopy is a powerful new tool that facilitates the study of discrete cellular processes within the three-dimensional, natural environment of intact organs in living animals. During the past few years, multi-photon microscopy has revolution See details	National Institutes of Health	5/06/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$500,000	Trans-NIH Recovery Act Research Support This project supports the purchase of an instrument that is dedicated to isolate cells from a variety of animal cells that are being used to develop new therapies at the University of Pennsylvania. In addition, this proposal will create or retain two jobs See details	National Institutes of Health	7/22/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$500,000	Trans-NIH Recovery Act Research Support Patient T cells may be genetically modified to target tumor through the introduction of genes encoding chimeric antigen recepters (CARS) specific to tumor associated antigens. Subsequently, CAR modified T cells may be adoptively transferred back into tumo This spending item is part of a $1,951,470 allocation. See details	National Institutes of Health	9/23/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$499,867	Trans-NIH Recovery Act Research Support Confocal microscopy and live cell imaging capabilities have facilitated the adoption of optical sectioning methods as a primary tool for use in biomedical research. Expansion of the School of Dental Medicines (SDM) Imaging and Analytical core (IAC) thro See details	National Institutes of Health	5/27/2010
FOX CHASE CANCER CENTER	$499,252	Trans-NIH Recovery Act Research Support Title: Symptom Cluster Assessment and Intervention Trial Description: This research addresses multiple cancer symptoms (fatigue, insomnia, pain, and depression) during chemotherapy using a specific symptom management protocol. The aims of the study are See details	National Institutes of Health	4/29/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$499,000	Trans-NIH Recovery Act Research Support This award is for the purchase of a Becton Dickinson Influx Flow Cytometer. This instrument will be configured with a biological safety cabinet that will permit the sorting and/or analysis of primary human cell populations, as well as primary cells and ce See details	National Institutes of Health	2/20/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$498,500	Trans-NIH Recovery Act Research Support This award enabled us to acquire a state-of-the-art 3-D conformal irradiator for small animals. This means that we will are now able to irradiate tumors and normal tissue in animals with vconditions very similar to those used for human radiation therapy. See details	National Institutes of Health	6/10/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$498,200	Trans-NIH Recovery Act Research Support Funds are requested to purchase a state of the art console and gradient amplifiers for a small animal magnetic resonance imaging (MRI) and spectroscopy scanner. The new instrumentation will be interfaced to an existing vertical bore 9.4 T, 8.9 cm magnet See details	National Institutes of Health	4/28/2009
AMERICAN COLLEGE OF RADIOLOGY, THE	$496,686	Trans-NIH Recovery Act Research Support This project is designed to shorten the timeline for activating National Cancer Institute(NCI) sponsored Cooperative Group phase 1-3 clinical trials thereby allowing patient accrual to the trials to start sooner and results analyzed and reported faster. T See details	National Institutes of Health	5/19/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$495,402	Trans-NIH Recovery Act Research Support The purpose of this supplement is to 1) accelerate the tempo of the core research and its clinical translation proposed under the parent grant by recruiting additional research personnel and 2) to translate the technologies developed under core research a See details	National Institutes of Health	9/08/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$493,625	Trans-NIH Recovery Act Research Support The project uses secondary data analyses and simulation studies to investigate the performance of methods for selection of optimal adaptive treatment strategies in alcoholism. We consider Bayesian and causal approaches, and consider up to four treatment s See details	National Institutes of Health	9/22/2009
URBAN LEAGUE OF PHILADELPHIA	$491,501	ARRA Child Care and Development Block Grant The American Recovery and Reinvestment Act (ARRA) Child Care and Development Fund (CCDF) funds have two mandatory earmarks, Infant/Toddler and Quality. The Infant/Toddler funds are utilized for new center-based Keystone Babies programs. Specifically, th This spending item is part of a $60,146,767 allocation. See details	Administration for Children and Families	4/09/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$485,394	Trans-NIH Recovery Act Research Support The long-range goal of this Program Project is to develop therapeutic strategies that ameliorate muscle atrophy and augment muscle rehabilitation following pathological conditions such as spinal cord injury. Muscle atrophy or loss of muscle mass is a per This spending item is part of a $2,298,355 allocation. See details	National Institutes of Health	9/30/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$484,872	Trans-NIH Recovery Act Research Support Genome wide association studies (GWAS) are typically carried out to uncoverpotential correlations between SNP genotypes and disease phenotypes. Often,cancer or neoplastic conditions have been the subject of these studies, and theyhave provided useful insi See details	National Institutes of Health	9/29/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$484,114	Trans-NIH Recovery Act Research Support This supplement requests support for the CEET to build capacity in its core mission which is to elucidate the mechanistic link between environmental exposures and human disease and translate these findings to improvements in patient and public health. See details	National Institutes of Health	9/02/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$484,008	Trans-NIH Recovery Act Research Support Many human diseases arise from errors in the molecular machinery for communication/signaling between and within cells, and a detailed understanding of the molecular events responsible will allow the design and development of therapeutic agents that can co See details	National Institutes of Health	8/14/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$478,021	Trans-NIH Recovery Act Research Support We propose additional quantitative, state-of-the-art image measurements of the developing brain and to speed-up the cross-sectional component of data collection. Both targets will contribute to economy by recruiting additional support staff. We propose See details	National Institutes of Health	9/28/2009
HEAD START LEARNING TREE	$476,850	ARRA - Head Start This award will bring Head Start services to a section of the city that has a number of pre-school age children but no pre-school services within a reasonable distance of their homes. The first $155,550 funding provided funds for the project start-up,tra See details	Administration for Children and Families	9/24/2009
THOMAS JEFFERSON UNIVERSITY	$475,508	Trans-NIH Recovery Act Research Support We proposed to speed the parent aims with high-precision Qpcr for hundreds of neural-genes for very large numbers of samples taken by laser capture microdissection (LCM) for single SCN neurons and for identified poplulations of light responsive neurons, k See details	National Institutes of Health	8/14/2009
THOMAS JEFFERSON UNIVERSITY	$470,424	Trans-NIH Recovery Act Research Support HS chains regulate key physiologic processes and do so by various mechanisms and most notably by restricting the topographical distribution of signaling factors within tissues, but it is not known whether defects in such signal-restriction mechanisms sub See details	National Institutes of Health	9/21/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$459,344	Trans-NIH Recovery Act Research Support The central theme of our research under is to develop lentiviral engineered T cells for treatment of HIV. After successful completion of the aims as set forth in our original IPCP application, we find ourselves in a unique position to directly compare len See details	National Institutes of Health	8/01/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$456,046	Trans-NIH Recovery Act Research Support Developing a Community-Based ASD Research Registry This application addresses Broad Challenge Area 05 (Comparative Effectiveness Research) & Specific Challenge Topic 05-MH-104 (Building ASD Registries for Use in Comparative Effectiveness Research). Enroll This spending item is part of a $500,000 allocation. See details	National Institutes of Health	9/28/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$452,375	Trans-NIH Recovery Act Research Support Foxp3, a 47-kDa transcription factor, is necessary and sufficient for development and function of natural Tregs. The role of Foxp3+ Tregs in controlling self-reactive T cells and preventing autoimmunity is well established. During comparison of Foxp3 expr See details	National Institutes of Health	6/04/2009
ESPERANZA HEALTH CENTER, INC.	$450,270	ARRA Health Center Integrated Services Development Initiative[g1] The CIP will provide needed renovation for Esperanza Health Center. Esperanza has doubled in size since 2006 and demand continues to outstrip supply for primary health services in the underserved Latino community of North Philadelphiaia. The project will r... Show more See details	Health Resources and Services Administration	6/25/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$450,000	Trans-NIH Recovery Act Research Support The proposed system will be used for obtaining high resolution structural images of small animals which will be used for better understanding of a variety of disorders and drug developments. The scanner will be used by several groups both within the Unive See details	National Institutes of Health	5/13/2010
THOMAS JEFFERSON UNIVERSITY	$449,986	Trans-NIH Recovery Act Research Support Our preliminary results show that exposure of epithelial cells to tungsten carbide cobalt (WC-Co) nanoparticles produced high levels of reactive oxygen species (ROS). WC-Co nanoparticles induced AKT and ERK1/2 activation, and increased the transcriptional This spending item is part of a $574,971 allocation. See details	National Institutes of Health	8/30/2010
THE INSTITUTE FOR CANCER RESEARCH	$448,495	Trans-NIH Recovery Act Research Support Title: Characterization of Type-2 Cytokine-Producing NK Cells Abstract: Allergic immune responses are biased toward the production of type-2 cytokines. We have identified new surface markers of a small subset of human natural killer (NK) cells that prod This spending item is part of a $503,770 allocation. See details	National Institutes of Health	6/04/2009
THE INSTITUTE FOR CANCER RESEARCH	$448,495	Trans-NIH Recovery Act Research Support Title: Characterization of Type-2 Cytokine-Producing NK Cells Abstract: Allergic immune responses are biased toward the production of type-2 cytokines. We have identified new surface markers of a small subset of human natural killer (NK) cells that prod This spending item is part of a $503,770 allocation. See details	National Institutes of Health	6/04/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$442,470	Trans-NIH Recovery Act Research Support The Neuroimage Analysis Center (NAC), a national resource center, is developing algorithms and image analysis software tools for improving our understanding of brain diseases and enabling innovative treatments. The focus of this competitive renewal is the This spending item is part of a $1,805,902 allocation. See details	National Institutes of Health	9/17/2009
FOX CHASE CANCER CENTER	$442,077	Trans-NIH Recovery Act Research Support Abstract: The Philadelphia Breast Cancer Family Registry is a clinic-based site, one of six collaborating Breast Cancer Family Registry (B-CFR) sites sponsored by the NCI. The overall goal is to maintain, enhance and exploit the research potential of the See details	National Institutes of Health	9/01/2009
WISTAR INSTITUTE OF ANATOMY & BIOLOGY	$437,410	Trans-NIH Recovery Act Research Support Epstein-Barr virus (EBV) infects over 95% of the adult population worldwide, and has been estimated to be a contributing agent in ~1% of all human cancer. Its carcinogenic potential is significantly elevated by immunosuppression, as is found in the conte This spending item is part of a $991,151 allocation. See details	National Institutes of Health	9/28/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$437,063	Trans-NIH Recovery Act Research Support An arteriovenous malformation (AVM) is a vascular malformation in the brain with direct connections between arteries and veins such that blood bypasses brain tissue. A patient with an AVM may not be aware of it until the AVM causes hemorrhage into the bra See details	National Institutes of Health	6/15/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$435,959	Trans-NIH Recovery Act Research Support Several devastating diseases that are caused by nerve degeneration, including amyotrophic lateral sclerosis (ALS), have been unified by a common underlying theme: the clumping of a protein, TDP 43, in nerve cells. Our proposed studies aim to provide new m See details	National Institutes of Health	9/20/2009
DREXEL UNIVERSITY	$433,736	Trans-NIH Recovery Act Research Support The overall goal in this program project is to understand the potential of ligands of the human immunodeficiency virus (HIV-1) gp120 envelope glycoprotein to inhibit virus entry. This Administrative supplement is submitted in response to NOT-OD-09-056: N This spending item is part of a $519,761 allocation. See details	National Institutes of Health	9/30/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$433,125	Trans-NIH Recovery Act Research Support Clearance of many viral infections is critically dependent on the function of CD8 T cells in the immune system. Recent results have shown that CD8 T cells become functionally defective when CD4 T cell help is absent. This loss of functionality in CD8 T c See details	National Institutes of Health	5/07/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$433,125	Trans-NIH Recovery Act Research Support The health relatedness of this project is that by completion of our aim we will ensure clearer understanding of the molecular and functional patho physiology of limb girdle muscular dystrophy Type 2B (LGMD2B) as well as facilitate preclinical development See details	National Institutes of Health	7/15/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$433,125	Trans-NIH Recovery Act Research Support Hepatitis is a pathological syndrome of liver injury that has several causes and is characterized by varying degrees of liver injury. Chronic hepatitis C and hepatitis B virus infections in humans result in liver damage, inflammation, and secondary develo See details	National Institutes of Health	5/29/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$433,125	Trans-NIH Recovery Act Research Support Novel approaches to treating nicotine dependence remain a priority. The transdermal nicotine patch is the most widely used form of tobacco dependence treatment, but only ~1 in 5 smokers who use this treatment achieve cessation. One factor that may contrib See details	National Institutes of Health	6/01/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$431,462	Recovery Act Comparative Effectiveness Research - AHRQ Bipolar is a severe and lifelong illness affecting 4.5% of the population ? about 14 million people in the U.S. It is one of the top 10 most disabling medical conditions worldwide according to the World Health Organization. Traditionally, the mooood stabili... Show more This spending item is part of a $9,784,863 allocation. See details	Agency for Healthcare Research and Quality	9/28/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$430,749	Trans-NIH Recovery Act Research Support Schistosomiasis is a major tropical disease caused by parasitic flatworms called schistosomes. Although there is an effective drug against schistosomiasis, the mechanism by which it works is unclear. By understanding that mechanism, it may be possible to See details	National Institutes of Health	5/14/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$429,712	The Systolic Blood Pressure Intervention Trial (SPRINT)-Senior ARRA expansion is designed to test the SPRINT intervention in participants who are ? 75 years of age. Approximately 3,250 of the 9,250 SPRINT participants are expected to be age 75 or older. I This spending item is part of a $2,392,562 allocation. See details	National Institutes of Health	9/24/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$427,626	Trans-NIH Recovery Act Research Support This activity extends the scope of CA079992, moving to studies of the intracellular domain specifically the ErbB3 kinase domain. The proposal is to test the physiological importance of kinase activity by this domain. Central to the proposal is recruit See details	National Institutes of Health	9/22/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$426,515	Trans-NIH Recovery Act Research Support Gene therapy is developing into a viable alternative for the treatment of many diseasesincluding immune system disorders, certain cancers, and even HIV infection. In genetherapy, a gene of interest is delivered to a target cell, which in some cases is aqu See details	National Institutes of Health	6/04/2009
THOMAS JEFFERSON UNIVERSITY	$424,875	Trans-NIH Recovery Act Research Support Many neurodegenerative diseases, including spinal and bulbar muscular atrophy (SBMA) and ALS, result from protein misfolding and accumulation due to a variety of both genetic and environmental causes. SBMA is an adult-onset neuromuscular disease that is c See details	National Institutes of Health	6/05/2009
THOMAS JEFFERSON UNIVERSITY	$424,875	Trans-NIH Recovery Act Research Support The proposed research addresses the development of a vaccine that would be effective for the control and prevention of Nipah virus (NiV) infection, which poses a serious public health as well as veterinary health hazard in the U.S. NiV is a newly describe See details	National Institutes of Health	5/21/2009
THOMAS JEFFERSON UNIVERSITY	$424,875	Trans-NIH Recovery Act Research Support The molecular mechanism involved in the tumor suppressing function of Fhit and Nit1 is not clear. Previous studies have shown that ectopic expression of Fhit or Nit1 can induce apoptosis in tumor cells, which requires caspase activation but is independen See details	National Institutes of Health	6/04/2009
DREXEL UNIVERSITY	$422,000	Trans-NIH Recovery Act Research Support This study aims to compare the effectiveness of traditional behavioral therapy (based on Brownell's LEARN program for weight management, 2000) with acceptance-based therapy (based on the behavioral and nutritional components of LEARN) for weight loss. Bro See details	National Institutes of Health	5/29/2009
DREXEL UNIVERSITY	$421,769	Trans-NIH Recovery Act Research Support Amyotrophic lateral sclerosis (ALS) is characterized by the progressive and selective loss of motor neurons (MNs) in the motor cortex, brainstem, and spinal cord, resulting in death of patients 2-5 years after diagnosis. Glutamate-mediated excitotoxicity See details	National Institutes of Health	6/15/2009
THOMAS JEFFERSON UNIVERSITY	$421,333	Trans-NIH Recovery Act Research Support G8pos skeletal muscle stem/progenitor cells may provide the source of ?-smooth muscle actin positive myofibroblasts detected in lens fibrotic diseases. We hypothesize that disruption of the G8pos epiblast-skeletal muscle stem cell niche, such that could See details	National Institutes of Health	7/22/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$420,366	Trans-NIH Recovery Act Research Support This award was made to support a project whereby the investigators plan to use synthetic genome technology to create a virulent version of a temperate bacterial virus that infects strains of Enterococcus faecalis. It is expected that such a deriviative o See details	National Institutes of Health	3/19/2010
CHILDRENS HOSPITAL OF PHILADELPHIA	$420,000	Trans-NIH Recovery Act Research Support Most strategies to increase marrow production of platelets have focused on use of positive cytokines such as thrombopoietin (TPO). We have recently described an important inhibitory loop that also regulates platelet counts. We found that at least one chem See details	National Institutes of Health	8/01/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$418,662	Trans-NIH Recovery Act Research Support The PLAAY intervention seeks to train parents to provide racial coping knowledge and emotionally supportive coaching to Black youth who often retaliate when stressed, feeling incompetent in classrooms or appearing weak in interpersonal conflicts on the pl See details	National Institutes of Health	5/27/2009
CARING PEOPLE ALLIANCE	$418,480	ARRA Child Care and Development Block Grant The American Recovery and Reinvestment Act (ARRA) Child Care and Development Fund (CCDF) funds have two mandatory earmarks, Infant/Toddler and Quality. The Infant/Toddler funds are utilized for new center-based Keystone Babies programs. Specifically, th This spending item is part of a $60,146,767 allocation. See details	Administration for Children and Families	4/09/2009
WISTAR INSTITUTE OF ANATOMY & BIOLOGY (INC)	$418,250	Trans-NIH Recovery Act Research Support Human cytomegalovirus (HCMV) infection has serious consequences for immunocompromised individuals, such as AIDS and organ transplant patients and congenitally infected newborns. Of symptomatic newborns, 12% die and many of the survivors suffer mental reta See details	National Institutes of Health	6/04/2009
DREXEL UNIVERSITY	$418,074	Trans-NIH Recovery Act Research Support The liver is the largest organ in the body. It is involved in a myriad of metabolic processes required for body homeostasis and can also detoxify harmful chemicals. The liver receives blood from the hepatic portal vein and the hepatic artery. The hepatic See details	National Institutes of Health	8/20/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$415,416	Trans-NIH Recovery Act Research Support A hallmark of solid tumors is the requirement to adapt to, and eventually overcome the stressful environment of low oxygen, growth factors, glucose and pH in the growing tumor mass. The requirement for neoangiogenesis to support tumor growth is now well e This spending item is part of a $695,927 allocation. See details	National Institutes of Health	7/16/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$412,500	Trans-NIH Recovery Act Research Support In this R21 application, we propose to test our hypothesis with the following specific aims using a murine model of allergic asthma: In Aim 1, we determine whether mice deficient in Muc1 expression fail to develop the type-2 immune response associated wit See details	National Institutes of Health	6/04/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$412,500	Trans-NIH Recovery Act Research Support A major contribution of this research is that the project will generate rich and in-depth data/evidence from a culturally diverse sample of urban-dwelling individuals with mental illness based on their lived experiences and perspectives to better conceptu See details	National Institutes of Health	4/30/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$408,200	Technical support and administrative/management services: Task Order 6, Antiviral and Immune Plasma Infrastructure Development This spending item is part of a $12,962,657 allocation. See details	National Institutes of Health	9/28/2009
GYNECOLOGIC ONCOLOGY GROUP , THE	$402,908	Trans-NIH Recovery Act Research Support The Gynecologic Oncology Group (GOG) is the foremost multidisciplinary cooperative clinical trial research group devoted to the study of gynecologic malignancies. Since its inception in 1970, the GOG has been a recognized leader in the development of new This spending item is part of a $678,418 allocation. See details	National Institutes of Health	8/20/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$399,514	Trans-NIH Recovery Act Research Support This challenge grant will help to stimulate the economy as it proposes to hire two new full-time research assistants. These individuals will work on a project aimed at assesing the social, behavioral, and ethical implications of direct availability of per This spending item is part of a $647,074 allocation. See details	National Institutes of Health	9/21/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$397,346	Trans-NIH Recovery Act Research Support As new HIV infections continue to occur at alarming rates, development of a strong and effective mucosal vaccine would have a huge public health impact. Thus there is a continuing need for new approaches for HIV-1 vaccination. This project focuses on the This spending item is part of a $799,977 allocation. See details	National Institutes of Health	9/17/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$396,028	Trans-NIH Recovery Act Research Support In this proposal high resolution diffusion tensor imaging of the mouse brain will be developed as surrogate markers to assess the social behavioral abnormalities in mouse models relevant to autism. Successful implementation of the proposed DTI techniques This spending item is part of a $453,459 allocation. See details	National Institutes of Health	9/16/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$393,400	Trans-NIH Recovery Act Research Support Funding was provided for salary and supplies to continue work to define the function of the Elys gene in intestinal progenitor cells.This project seeks to define cellular and molecular mechanisms that prevent theoccurrence of oncogenic mutations caused by See details	National Institutes of Health	8/13/2010
AMERICAN COLLEGE OF RADIOLOGY, THE	$392,236	Trans-NIH Recovery Act Research Support The American College of Radiology Imaging Network (ACRIN) was established as a consortium to generate, execute and report on multicenter clinical trials in imaging as it relates to cancer. ACRIN, like other NCI funded cooperative research groups, has note See details	National Institutes of Health	5/27/2010
CHILDRENS HOSPITAL OF PHILADELPHIA	$391,559	Trans-NIH Recovery Act Research Support This supplemental award provides support to Therapeutically Applicable Research to Generate Effective Treatments (TARGET) Supplements including: 1) High Risk Acute Lymphoblastic Leukemia (HR-ALL) - Our results establish that we can use comprehensive genom This spending item is part of a $4,023,579 allocation. See details	National Institutes of Health	9/15/2009
THOMAS JEFFERSON UNIVERSITY	$386,250	Trans-NIH Recovery Act Research Support The goal of these studies is to determine the mechanisms utilized by mouse and human neutrophils to control helminth infections. Previous studies have demonstrated that neutrophils are required for killing larval Strongyloides stercoralis in na+?ve and im See details	National Institutes of Health	8/01/2009
THOMAS JEFFERSON UNIVERSITY	$386,250	Trans-NIH Recovery Act Research Support G protein-mediated signaling pathways regulate numerous physiological responses, including cardiovascular function, neurotransmitter responses, cell differentiation, cell migration, immune cell function, and smell, taste, and vision; and dysregulation of See details	National Institutes of Health	9/29/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$385,878	Trans-NIH Recovery Act Research Support Although urokinase (uPA) and its receptor strongly contribute to the dissemination of prostate cancer, the efficacy of existing approaches to disable this system is incomplete, possibly because uPA acts through additional uncharacterized pathways. We rece See details	National Institutes of Health	7/17/2009
THE INSTITUTE FOR CANCER RESEARCH	$383,568	Trans-NIH Recovery Act Research Support The large ongoing NIH COPDGene® trial is a genome wide association study designed to elucidate the genetic basis of chronic obstructive pulmonary disease (COPD). This study also provides a unique opportunity to rapidly develop plasma biomarkers for C This spending item is part of a $1,576,840 allocation. See details	National Institutes of Health	9/25/2009
HEAD START LEARNING TREE	$381,543	ARRA - Head Start Head Start 2009 ARRA COLA Quality Improvement Funding See details	Administration for Children and Families	5/28/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$381,150	Trans-NIH Recovery Act Research Support Head and neck cancers (HNC) are the sixth most common form of cancer worldwide, with over 500,000 new cases diagnosed annually. Although advances in surgery, and combined of radio and chemotherapies, have decreased morbidity, the survival rate at 5 years See details	National Institutes of Health	5/21/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$381,140	Trans-NIH Recovery Act Research Support Many types of cancer exist in the body in environments that are highly acidic (low pH) compared with normal healthy tissue. This increase is acidity is believed to contribute to cancer progression and its resistance to therapy. For these reasons, we hyp See details	National Institutes of Health	6/05/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$376,800	Trans-NIH Recovery Act Research Support as defined in the award description. PI has left the University. Final report will be submitted next qtr See details	National Institutes of Health	7/16/2009
THOMAS JEFFERSON UNIVERSITY	$373,890	Trans-NIH Recovery Act Research Support We have recently imported into our laboratory the Sleeping Beauty transposon system. The sleeping beauty transposon is a transposable mobile element that requires two unlinked genetic loci and has been shown to induce tumorigenesis in the mouse. Making us See details	National Institutes of Health	5/13/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$373,275	Trans-NIH Recovery Act Research Support We have developed a plan for a NINDS research organization/consortium to develop, characterize and study iPS cell lines for Parkinson's disease (PD). The overall goal of this consortium of multiple- Pis (see leadership plan) is to organize the rapidly exp This spending item is part of a $3,700,091 allocation. See details	National Institutes of Health	9/28/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$368,000	Trans-NIH Recovery Act Research Support The purpose of this ARRA administrative supplement is to perform microarray analyses using existing samples collected by the GPN PBR to identify circulating miRNAs as biomarkers of spontaneous preterm delivery in maternal serum, and tissue levels of miRNA See details	National Institutes of Health	8/18/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$366,648	Trans-NIH Recovery Act Research Support Prostate cancer is the second leading cause of cancer death in man. It is initially responsive to androgen ablative therapy but thereafter patients relapse and develop castration resistant prostate cancer (CRPC). Emerging data suggests that CRPC has under This spending item is part of a $505,848 allocation. See details	National Institutes of Health	9/24/2009
DREXEL UNIVERSITY	$366,032	Trans-NIH Recovery Act Research Support The purpose of this supplement is to accelerate enrollment of the EARLI cohort as well as expand enrollment diversity and enhance retention. Each of the four study sites will hire one additional dedicated outreach/recruitment specialist to help increase This spending item is part of a $1,111,301 allocation. See details	National Institutes of Health	9/20/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$363,723	ARRA - Maternal and Child Health (MCH) Pediatric Research Network Program PROS has been funded by the Department of Health and Human Services (DHHS) and the Health Resources and Services Administration Maternal and Child Health Bureau (HRSA MCHB) for a three-year, $3.5 million project, in which a samample of willing PROS practice... Show more This spending item is part of a $3,499,979 allocation. See details	Health Resources and Services Administration	8/27/2010
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$363,000	Trans-NIH Recovery Act Research Support BCR/ABL fusion tyrosine kinase results from t(9;22) reciprocal chromosomal translocation and is leukemogenic only when expressed in a hematopoietic stem cells (HSCs) with self-renewal capacity thereby inducing leukemia stem cell (LSC). LSCs are capable to See details	National Institutes of Health	7/16/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$359,939	Trans-NIH Recovery Act Research Support This application addresses the Challenge Area (15) 'Translational Science' and the Challenge Topic 15- OD(ORDR)-101 'Pilot Projects for Prevention, Early Detection and Treatment of Rare Diseases'. Hereditary Multiple Exostosis Syndrome (HME) is a rare au See details	National Institutes of Health	3/26/2011
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$359,936	Trans-NIH Recovery Act Research Support Thyroid hormone receptors (TRs) are ligand dependent, transcriptional regulators of metabolism. TRs repress gene expression in the absence of hormone, which is paradigmatic for other nuclear receptors (NRs) that function as repressors in the unliganded st See details	National Institutes of Health	9/28/2009
PHILADELPHIA PARENT CHILD CENTER	$357,711	ARRA Child Care and Development Block Grant The American Recovery and Reinvestment Act (ARRA) Child Care and Development Fund (CCDF) funds have two mandatory earmarks, Infant/Toddler and Quality. The Infant/Toddler funds are utilized for new center-based Keystone Babies programs. Specifically, th This spending item is part of a $60,146,767 allocation. See details	Administration for Children and Families	4/09/2009
COMMUNITY DEVELOPMENT INSTITUTE HEAD START	$357,698	ARRA - Head Start This award provides ARRA funds for Head Start and Early Head Start and Cost of Living Adjustments (COLA) in accordance with FY 2009 Funding guidance ACF-PI-HS-09-06. Head Start promotes the school readiness of low-income children through the provision of See details	Administration for Children and Families	9/02/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$355,159	Trans-NIH Recovery Act Research Support Insomnia and sleep apnea (abnormal breathing patterns during sleep) are common in older adults and may each lead to increased risk of disease or death. Insomnia and sleep apnea may exist together in older adults in about 30% of cases and this combined sta See details	National Institutes of Health	5/14/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$353,315	Trans-NIH Recovery Act Research Support An unfortunate consequence of the treatments currently used to treat pediatric cancers is infertility. An important issue to consider is whether a child's fertility status later in life is likely to be impacted by his treatment. Ideally, this should occu This spending item is part of a $465,023 allocation. See details	National Institutes of Health	9/22/2009
WISTAR INSTITUTE OF ANATOMY & BIOLOGY	$353,098	Trans-NIH Recovery Act Research Support The identification of a small subset of HIV-1 infected subjects that exhibit spontaneous control of viral replication (VL<75 copies RNA/mL) in the absence of anti-retroviral therapy (elite controllers) has heightened interest in the mechanism(s) of immune This spending item is part of a $467,428 allocation. See details	National Institutes of Health	5/21/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$352,513	ARRA - Scholarships for Disadvantaged Students The title of the grant is: Scholarships for Disadvantaged Students (SDS)for Medical, Dental, Pharmacy and Baccalaureate Nursing students. This grant provides financial aid scholarships to qualified disadvantaged graduate students in Temple University's p pr... Show more See details	Health Resources and Services Administration	6/14/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$350,032	Trans-NIH Recovery Act Research Support The primary intent for the confocal core is to substantively advance the science of a selected groups of NIH funded projects here in the Translational Research Building at the University of Pennsylvania. The secondary goals with this new equipment includ See details	National Institutes of Health	5/07/2009
THE INSTITUTE FOR CANCER RESEARCH	$349,348	Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area #8, Genomics, and specific Challenge Topic 08-HL-101, which seeks to identify causal genetic variants associated with heart, lung, and blood diseases by application of targeted DNA capture and massively para This spending item is part of a $999,815 allocation. See details	National Institutes of Health	9/21/2009
FOX CHASE CANCER CENTER	$349,000	Trans-NIH Recovery Act Research Support 5-aminosalicylic acid (5-ASA) represents a promising agent for the chemoprevention of colorectal cancer in patients with ulcerative colitis. However, the precise molecular mechanism by which 5-ASA inhibits tumor formation remains unclear and is most like See details	National Institutes of Health	9/28/2009
WISTAR INSTITUTE OF ANATOMY & BIOLOGY	$347,144	Trans-NIH Recovery Act Research Support Our overarching goals are to design better therapies for the treatment of brain tumors. Medulloblastoma, a pediatric malignancy of the cerebellum with the highest incidence of all pediatric brain tumors, and glioma, themost malignant and invasive adult br This spending item is part of a $853,079 allocation. See details	National Institutes of Health	7/16/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$346,379	Trans-NIH Recovery Act Research Support All living things need sulfur, and cysteine desulfurases are necessary to provide sulfur in the proper form. These enzymes are found primarily in mitochondria in all human cells. Here we aim to characterize for the first time the active mitochondrial cyst This spending item is part of a $662,783 allocation. See details	National Institutes of Health	9/25/2009
DREXEL UNIVERSITY	$345,938	Trans-NIH Recovery Act Research Support This is an application to develop an orally available imino sugar for the treatment of flaviviruses infections of bioterror concern, with a focus upon West Nile Encephalitis virus (WNEV) and Dengue Viruses (DV). Our lead compound, the imino sugar, N, -non See details	National Institutes of Health	3/22/2010
FOX CHASE CANCER CENTER	$345,299	Trans-NIH Recovery Act Research Support Abstract Although individuals with ulcerative colitis face an increased risk of developing colorectal cancer, little attention has been given to the establishment of a chemopreventive regimen for this population. The ability of 5-aminosalicyclic acid (5- This spending item is part of a $664,093 allocation. See details	National Institutes of Health	9/18/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$344,689	Trans-NIH Recovery Act Research Support Heart failure affects more than 5 million Americans, and strikes over 500,000 new patients each year. Due in the majority of instances to dilated or ischemic cardiomyopathies, heart failure is a classic 'complex disease', i.e. it is multi-factorial and ha This spending item is part of a $1,905,001 allocation. See details	National Institutes of Health	9/28/2009
THOMAS JEFFERSON UNIVERSITY HOSPITALS, INC.	$341,266	Trans-NIH Recovery Act Research Support We have developed a safe and effective transplant approach for both matched sibling and haploidentical related transplants which addresses the problem of donor availability in patients with leukemia, lymphoma, and related disorders. This approach has been This spending item is part of a $1,953,226 allocation. See details	National Institutes of Health	9/28/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$338,035	Trans-NIH Recovery Act Research Support Schizophrenia is currently thought to be a complex genetic disorder, with early developmental abnormalities in brain structure and function, being important in determining vulnerability to illness. This study will examine changes in smell abilities in sch See details	National Institutes of Health	9/28/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$332,800	Trans-NIH Recovery Act Research Support Exposure to prenatal inflammation, as occurs in many preterm births, is associated with a significant increased risk of adverse neurological outcomes. Ex preterm children are at dramatically increased risk of lower IQs, poor functioning in school as well See details	National Institutes of Health	8/11/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$332,423	Trans-NIH Recovery Act Research Support This administrative supplement has supported the development of the MADCaP consortium, an international multicenter group of prostate cancer studies. This project is highly efficient and will be able to respond quickly to the important question of geneti See details	National Institutes of Health	9/29/2009
MATERNITY CARE COALITION	$331,519	ARRA - Prevention and Wellness--Communities Putting Prevention to Work PhiladelphiaG??s nutrition and physical activity challenges are daunting: nearly half of children are overweight or obese, low-income communities have little access to healthy foods, and opportunities for physical activity in schohools, neighborhoods, and w... Show more This spending item is part of a $15,018,277 allocation. See details	Centers for Disease Control and Prevention	3/19/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$331,001	ARRA - Preventive Medicine Residency Program This is an application for funding of an existing Occupational and Environmental Medicine Residency at the University of Pennsylvania. We plan to continue a highly successful Practicum Year residency training program, directed primarily at experienced phyy... Show more See details	Health Resources and Services Administration	7/02/2010
CHILDRENS HOSPITAL OF PHILADELPHIA	$329,532	Trans-NIH Recovery Act Research Support The goal of this project is to employ embryonic stem (ES) cell and induced pluripotent stem (iPS) cell systems to define the genetic and epigenetic programs of the earliest stages of human development, and to decipher whether identifiable components of th This spending item is part of a $2,716,079 allocation. See details	National Institutes of Health	9/25/2009
HEALTH FEDERATION OF PHILADELPHIA, THE	$327,169	ARRA Health Center Integrated Services Development Initiative[g1] The Health Federation of Philadelphia (HFP) is proposing an HIT Innovations project, which will expand the capacity and content of a clinical data warehouse that was created under an earlier phase of this ongoing strategic project. Thehe purpose of the data... Show more See details	Health Resources and Services Administration	6/01/2010
FOX CHASE CANCER CENTER	$325,205	Trans-NIH Recovery Act Research Support Lincoln University ? Fox Chase Partnership in Cancer Research and Training A P20 partnership was established between Fox Chase Cancer Center (FCCC) and Lincoln University (LU) Pennsylvania to train Lincoln students and faculty in cancer research, health See details	National Institutes of Health	6/05/2009
AMERICAN COLLEGE OF RADIOLOGY, THE	$324,683	Trans-NIH Recovery Act Research Support The main objective of this grant to provide support for the integration, standardization, and coordination of standardized information-technology (IT) tools and operational procedures for the Radiation Therapy Oncology Group (RTOG). Specifically we inten See details	National Institutes of Health	9/22/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$319,949	Trans-NIH Recovery Act Research Support The overall goal of the parent grant related to this supplement is to understand the role of diacylglycerol kinases (DGKs) in T cell and mast cell biology. The experiments that we propose for this supplement extend but directly relate to this goal by dev See details	National Institutes of Health	6/28/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$319,167	Trans-NIH Recovery Act Research Support This proposal will result in the creation of one new job, a postdoctoral researcher hired specifically for this competitive revision. Moreover, the studies proposed here will provide new approaches to the diagnosis and treatment of esophageal squamous ce See details	National Institutes of Health	9/29/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$318,994	Trans-NIH Recovery Act Research Support This is a administrative supplement. It is for expansion of studies relating to the engagement of the heterotrimeric G protein G13 by Sonic hedgehog and other agonists as they relate to the activation of Gli transcription factors. See details	National Institutes of Health	7/17/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$318,794	Trans-NIH Recovery Act Research Support Abstract Although individuals with ulcerative colitis face an increased risk of developing colorectal cancer, little attention has been given to the establishment of a chemopreventive regimen for this population. The ability of 5-aminosalicyclic acid (5- This spending item is part of a $664,093 allocation. See details	National Institutes of Health	9/18/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$318,667	Trans-NIH Recovery Act Research Support The Penn Diabetes and Endocrinology Research Center (DERC) participates in the nationwide interdisciplinary program established nearly three decades ago by the NIDDK to foster research and training in the areas of diabetes and related endocrine and metabo See details	National Institutes of Health	12/04/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$318,666	Trans-NIH Recovery Act Research Support The studies described in this proposal extend our current investigation on the role of Cdt as a putative virulence factor to a consideration of its utility as a potential therapeutic agent for treating certain types of cancer with defects in the PI-3K/PIP See details	National Institutes of Health	9/25/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$318,479	Trans-NIH Recovery Act Research Support The goal of this Supplement is to provide funds for the hiring of an additional research nurse coordinator in order to facilitate the implementation of multiple research protocols. As noted, the RMN now has multiple protocols implemented, all of which are See details	National Institutes of Health	9/30/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$311,698	Trans-NIH Recovery Act Research Support This proposal describes supplemental aims designed to improve the speed and quality of the pharmacodynamic assays for autophagy inhibition, and the integrative analysis and data reporting for the pharmacokinetic and genetic endpoitns of the parent R21 gra See details	National Institutes of Health	8/31/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$311,111	ARRA - Scholarships for Disadvantaged Students ARRA funds to augment Scholarships for Disadvantaged Students. When awarding Scholarships for Disadvantaged Students, preference was given tothose students for whom the cost of attendance constitutes a severe financial hardship.Currently no students enrnro... Show more See details	Health Resources and Services Administration	6/14/2010
PHILADELPHIA CORPORATION FOR AGING	$308,317	ARRA - Communities Putting Prevention to Work: Chronic Disease Self-Manage In collaboration with the American Recovery and Reinvestment Act (ARRA)-funded Communities Putting Prevention to Work (CPPW) program, this ARRA funding will support the deployment of evidence-based chronic disease self-managemement programs (CDSMP) that emp... Show more This spending item is part of a $1,000,000 allocation. See details	Administration on Aging	3/26/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$308,284	Trans-NIH Recovery Act Research Support While the control of the tyrosine kinase activity of the EGF receptor is understood at certain levels, the contributions of the cytoplasmic juxtamembrane (JM) and carboxyterminal (CT) regions, which are adjacent to the kinase domain, are not clear. These This spending item is part of a $785,052 allocation. See details	National Institutes of Health	9/30/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$307,535	Trans-NIH Recovery Act Research Support This competitive supplement application proposes a genome wide association study to engage in discovery to identify potential novel pathways explanatory of the progression of renal disease. This spending item is part of a $2,100,000 allocation. See details	National Institutes of Health	9/29/2009
Asian Community Health Coalition	$307,120	Trans-NIH Recovery Act Research Support The administrative supplement aims to reduce Hepatitis B health disparities for medically underserved Korean Americans using CBPR approaches. Specifically, this supplement will enable us to strengthen and expand the community research infrastructure and c This spending item is part of a $596,678 allocation. See details	National Institutes of Health	9/21/2009
HEALTH PROMOTION COUNCIL OF SOUTHEASTERN PENNSYLVANIA, INC.	$306,751	ARRA - Prevention and Wellness--Communities Putting Prevention to Work PhiladelphiaG??s nutrition and physical activity challenges are daunting: nearly half of children are overweight or obese, low-income communities have little access to healthy foods, and opportunities for physical activity in schohools, neighborhoods, and w... Show more This spending item is part of a $15,018,277 allocation. See details	Centers for Disease Control and Prevention	3/19/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$306,400	Trans-NIH Recovery Act Research Support This administrative supplemental request involves 5 projects under the umbrella of the A2ALL UO1. Each of the projects addresses a specific aim of the parent grant, with the goal to complete data collection, standardize results, or accelerate sample analy See details	National Institutes of Health	2/03/2010
FOX CHASE CANCER CENTER	$306,280	Trans-NIH Recovery Act Research Support The overall purpose of GMaP is to create state-of-the-art regional networks or centers dedicated to cancer health disparities research and care. This award covers Area 5, which includes Massachusetts, Michigan, Minnesota, New York, Ohio, and Pennsylvania This spending item is part of a $343,215 allocation. See details	National Institutes of Health	9/23/2009
DREXEL UNIVERSITY	$306,072	Trans-NIH Recovery Act Research Support This research grant will attempt to identify all the serum glycoproteins that have increased levels of fucosylation in the sera of patients with hepatocellular carcinoma (HCC). It is acknowledged in the literature that changes in glycosylation occur with See details	National Institutes of Health	9/30/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$305,871	Trans-NIH Recovery Act Research Support The majority of individuals in criminal justice settings across the U.S. have a critical need for sciencebased, psychosocial treatment that targets substance use and HIV risk behavior. The investigative team has developed and demonstrated the efficacy of This spending item is part of a $3,439,782 allocation. See details	National Institutes of Health	9/28/2009
TEMPLE UNIVERSITY	$305,871	Trans-NIH Recovery Act Research Support The majority of individuals in criminal justice settings across the U.S. have a critical need for sciencebased, psychosocial treatment that targets substance use and HIV risk behavior. The investigative team has developed and demonstrated the efficacy of This spending item is part of a $3,439,782 allocation. See details	National Institutes of Health	9/28/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$305,189	Trans-NIH Recovery Act Research Support Our original application (R01 HD048730, Stability of Epigenetic Structures in ART Children) had three specific aims centered on the hypothesis that Assisted Reproductive Technology (ART) can destabilize the establishment or faithful propagation of epigene See details	National Institutes of Health	9/28/2009
DREXEL UNIVERSITY	$304,762	Trans-NIH Recovery Act Research Support The ultimate goal of this request for support for the re-entry of a scientist is for the re-entering candidate to establish an effective and successful independent research program, in less than 2 years, while accelerating the pace of accomplishment of th See details	National Institutes of Health	9/22/2009
COLLEGE OF PHYSICIANS OF PHILADELPHIA	$303,482	ARRA - Prevention and Wellness--Communities Putting Prevention to Work PhiladelphiaG??s nutrition and physical activity challenges are daunting: nearly half of children are overweight or obese, low-income communities have little access to healthy foods, and opportunities for physical activity in schohools, neighborhoods, and w... Show more This spending item is part of a $15,018,277 allocation. See details	Centers for Disease Control and Prevention	3/19/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$303,357	Trans-NIH Recovery Act Research Support This administrative supplement will support the timely review of Serious Adverse Events in patients participating in the Lucentis Avastin clinical trial for neovascular age related macular degeneration. In addition, the reserach coordinator hired will pr See details	National Institutes of Health	8/19/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$302,579	Trans-NIH Recovery Act Research Support Continued follow up of a cohort of approximately 4000 individuals with chronic kidney disease across the nation, examining the rate and correlates of progression of their kidney disease as well as cardiovascular outcomes. See details	National Institutes of Health	9/30/2010
MONELL CHEMICAL SENSES CENTER	$302,315	Trans-NIH Recovery Act Research Support The sense of taste is the primary sensory system that determines whether a food or beverage will be ingested or rejected. Taste also influences food processing by the digestive system. Consequently, understanding the mechanisms underlying this sense is ce See details	National Institutes of Health	7/15/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$301,660	Trans-NIH Recovery Act Research Support The O Brien Urology Research Program addresses the cellular molecular mechanisms that cause stress and obstruction induced lower urinary tract symptoms (LUTS). . The three new P and F projects that are included in the Administrative Supplement. Th This spending item is part of a $421,456 allocation. See details	National Institutes of Health	9/29/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$301,637	Trans-NIH Recovery Act Research Support This supplement addresses the development and implementation of a new support service within the Biomedical imaging core of our comprehensive cancer center. It will allow us to implement support of novel imaging and physiologic modeling within translatio See details	National Institutes of Health	9/29/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$300,696	Trans-NIH Recovery Act Research Support The requested supplement meets the Recovery Act goals. It created a full time job with benefits for the mentee. The research and career development experiences will accelerate the pace and achievement of scientific research by equipping her with the skil See details	National Institutes of Health	9/28/2009
MONELL CHEMICAL SENSES CENTER	$300,047	Trans-NIH Recovery Act Research Support Odor information is encoded by selective activation of olfactory receptors and mapped topographically to glomeruli in the olfactory bulb. Our broad, long term objective is to understand dendritic and synaptic signaling mechanisms in the bulb that transfor See details	National Institutes of Health	9/07/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$298,560	ARRA ? Equipment to Enhance Training for Health Professionals This grant is titled ARRA - Equipment to Enhance Training for Health Professionals. The purpose of this grant is to replace and upgrade equipment at the Temple Community Clinic at Temple University's Maurice H. Kornberg School of Dentisistry(TUKSoD). The... Show more See details	Health Resources and Services Administration	9/01/2010
CHILDRENS HOSPITAL OF PHILADELPHIA	$297,905	Trans-NIH Recovery Act Research Support Children with Autism Spectrum Disorders (ASD) are impaired in their ability to produce and perceive dynamic facial expressions (Adolphs, Sears, and Piven, 2001). Advanced computer vision technologies can now be leveraged in the investigation of issues suc This spending item is part of a $991,790 allocation. See details	National Institutes of Health	9/25/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$294,939	Trans-NIH Recovery Act Research Support This adminstrative supplement is for resequencing and additional genotyping. The supplement will enable the retention of laboratory personnel and enable accelerated progress of the grant, as well as provide preliminary data for other grant funding. See details	National Institutes of Health	9/21/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$293,692	Trans-NIH Recovery Act Research Support The proposed studies will provide important and novel data on environmental, situational, and individual factors in male and female adolescents who experience injuries. We will characterize the types of injuries and the exposure to alcohol in the communit See details	National Institutes of Health	8/15/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$292,762	Trans-NIH Recovery Act Research Support The proposed studies will increase our basic knowledge and understanding of human development. These studies will improve treatment of human infertility by providing new knowledge that will facilitate the rational development of treatments that foster im See details	National Institutes of Health	9/28/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$291,870	Trans-NIH Recovery Act Research Support Proposal to focus on the production of G protein coupled receptors and their structural characterization by a novel NMR based approach. The requested funds will allow us to purchase equipment and hire additional technical help for the production of protei See details	National Institutes of Health	9/30/2009
COLLEGE OF PHYSICIANS OF PHILADELPHIA	$290,935	ARRA - Prevention and Wellness--Communities Putting Prevention to Work This past quarter, PhiladelphiaG??s CPPW was able to make great strides in in completing its main tobacco control objectives. An executive order made 183 recreation centers, playgrounds, and outdoor pools smoke-free, affecting ovever 3.7 million visits. New... Show more This spending item is part of a $10,356,927 allocation. See details	Centers for Disease Control and Prevention	3/19/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$290,927	Trans-NIH Recovery Act Research Support The principal goals of this research program entail the discovery of new catalytic asymmetric transformations for organic synthesis. Synthetic reactions under investigation include Claisenrearrangements and a iminoester additions. To achieve these goals, See details	National Institutes of Health	8/14/2009
THOMAS JEFFERSON UNIVERSITY	$289,925	Trans-NIH Recovery Act Research Support A growing body of experimental evidence suggests that hemoglobin release from lysing erythrocytes may contribute to oxidative injury to tissue surrounding a hematoma. Prior studies have demonstrated that hemoglobin toxicity is mediated by transfer of its See details	National Institutes of Health	9/15/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$289,558	Trans-NIH Recovery Act Research Support The administrative supplement aims to reduce Hepatitis B health disparities for medically underserved Korean Americans using CBPR approaches. Specifically, this supplement will enable us to strengthen and expand the community research infrastructure and c This spending item is part of a $596,678 allocation. See details	National Institutes of Health	9/21/2009
THOMAS JEFFERSON UNIVERSITY	$289,520	Trans-NIH Recovery Act Research Support This application is for support to purchase a Leica AM TIRF (total internal reflection fluorescence) microscope system. The instrument will be housed within the - Facility of the Kimmel Cancer Center of Thomas Jefferson University. This Facility provides See details	National Institutes of Health	5/21/2009
SAYRE HEALTH CENTER	$287,415	ARRA Health Center Integrated Services Development Initiative[g1] Capital Improvement Program Award See details	Health Resources and Services Administration	6/25/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$285,033	Trans-NIH Recovery Act Research Support It is the primary objective of this program to elucidate correlates of immune-mediated protection against HIV-1 infection using pre-clinical animal models. To this end, Project 1 will determine humoral and cell-mediated immune responses to an attenuated S This spending item is part of a $5,581,859 allocation. See details	National Institutes of Health	9/01/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$282,993	Trans-NIH Recovery Act Research Support The Specific Aim of this supplement is to provide optimized, state of the art spinning disk confocal and live cell imaging within the Morphology Core for members of the Center for Molecular Studies in Digestive and Liver Disease at the University of Penns See details	National Institutes of Health	7/16/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$281,357	Trans-NIH Recovery Act Research Support This supplement is used to cover the salary of a senior postdoc candidate who was adversely affected by the economic crisis and lack of job opportunities. Additional funds were requested for equipment needed to perform the research. The work should allow See details	National Institutes of Health	9/18/2009
DREXEL UNIVERSITY	$280,059	Trans-NIH Recovery Act Research Support Genomic instability is a major cause of various genetic diseases. To understand how cells preserve genomic integrity, our investigation focuses on the role of replication fork proteins in genome maintenance mechanisms. Genomic instability is often associa See details	National Institutes of Health	7/15/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$278,515	Trans-NIH Recovery Act Research Support Ambiguity in language is everywhere, and communication fails when the listener does not resolve ambiguity in the way the speaker intends. Our research program aims to characterize the importance of cognitive control for ambiguity resolution in multiple do See details	National Institutes of Health	7/17/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$277,008	Trans-NIH Recovery Act Research Support With this award our goal is to use biomarkers of platelet factor 4 (PF4), platelet activation and immune response, along with clinical factors to identify patients at risk of heparin/PF4 antibody formation. Patients who undergo surgery requiring cardiopu This spending item is part of a $996,583 allocation. See details	National Institutes of Health	11/25/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$272,244	Trans-NIH Recovery Act Research Support The request for an administrative supplement to HL 086699, entitled Coordination of Pathophysiologic Endothelial Cell Signaling by ROS. The purpose of the requested supplement is to allow us to hire Wan Ting Saw, who graduated with a BS in Biology in May See details	National Institutes of Health	7/16/2009
THE CHILDREN'S HOSPITAL OF PHILADELPHIA	$271,423	Trans-NIH Recovery Act Research Support Numerous human disorders arise from microdeletions and microduplications of relatively large genomic regions. These rearrangements can result in copy number alterations (CNAs) of one or more genes. Conditions arising from microdeletions and microduplicati See details	National Institutes of Health	7/31/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$270,051	Trans-NIH Recovery Act Research Support Determination of a high resolution structure of the InsP3R C tail in complex with Bcl xL will provide a basis for understanding how binding of Bcl xL affects channel Ca2+ signaling functions, with relevance for cell death mechanisms in cancer and neurodeg See details	National Institutes of Health	9/30/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$266,931	Trans-NIH Recovery Act Research Support The main goal of the proposed supplement is to examine the effect of Ate1 knockout on adhesion, migration, and contractility of major cell types relevant to cardiovascular development. These studies will build on the results obtained in aim 3 of the pare See details	National Institutes of Health	7/16/2009
THOMAS JEFFERSON UNIVERSITY	$266,801	Trans-NIH Recovery Act Research Support In the Americas, bats represent a major reservoir for rabies virus (RV) and most of the human rabies cases that were reported during the last twenty years in the US were caused by RV variants that circulate in bat species. Unlike the classical human rabie This spending item is part of a $396,801 allocation. See details	National Institutes of Health	5/21/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$265,705	Trans-NIH Recovery Act Research Support Appropriate expression and regulation of imprinted genes is critical for normal development, with mistakes in imprinted gene expression involved in a number of syndromes and cancer. This application will study the regulation of the H19 and Igf2 locus. Err See details	National Institutes of Health	8/10/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$265,691	Trans-NIH Recovery Act Research Support The overall purpose of this supplement award is to accelerate the tempo of research, to retain jobs, and to help create jobs. All the goals have been achieved. With this award, we were able to speed up our research on the role of a very important gene, ca See details	National Institutes of Health	7/16/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$263,409	Trans-NIH Recovery Act Research Support The specific aims of the project included the following. This project proposes new ways to analyze B-W mortality disparities in the U.S. between 1980 and 2005 by investigating the contribution of causes of death considered amenable by (1) high-quality This spending item is part of a $433,891 allocation. See details	National Institutes of Health	9/22/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$262,872	Trans-NIH Recovery Act Research Support This project is designed to identify genetic variants that confer susceptibility to common forms of epilepsy including i) forms of idiopathic generalized epilepsy (IGE) such as juvenile myoclonic epilepsy (JME), childhood absence epilepsy (CAE) and idiopa This spending item is part of a $1,820,924 allocation. See details	National Institutes of Health	9/20/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$262,494	Trans-NIH Recovery Act Research Support The recent advances in our understanding of the molecular basis for a broad range of pediatric diseases, coupled with the legislative changes culminating in the Best Pharmaceuticals for Children Act, has dramatically increased the potential for defining n See details	National Institutes of Health	7/16/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$257,336	Trans-NIH Recovery Act Research Support These experiments will conclusively demonstrate or refute the importance of corin activity to the autocrine paracrine anti hypertrophic actions of the endogenous NPS, and provide biological confirmation for our previous genetic association studies that ha See details	National Institutes of Health	8/10/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$254,993	Trans-NIH Recovery Act Research Support This proposal is in direct response to the American Recovery and Reinvestment Act and puts forward a research plan to be carried out by a new postdoctoral fellow that has been hired at funding receipt. The primary goal of the Administrative Supplement re See details	National Institutes of Health	7/16/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$254,258	Trans-NIH Recovery Act Research Support The supplement has enable the group to retain a highly productive and experienced Research Specialist who otherwise would have her position. Additionally, the extended research proposed here is likely to add substantially to our understanding of subcellul See details	National Institutes of Health	9/24/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$252,038	Trans-NIH Recovery Act Research Support The additional funds allowed us to accelerate progress towards achieving our original goals by providing for thegeneration of doxycycline inducible transgenic lines targeting the bulge. These lines will bevaluable to the scientific community. There have b See details	National Institutes of Health	9/18/2009
QUALITY COMMUNITY HEALTH CARE, INC.	$250,445	ARRA Health Center Integrated Services Development Initiative[g1] The Increased Demand for Services program grant allows funding for projects that address the increased needs for and access to health services among the recent unemployed and uninsured in the community. This award will enable the organanization to meet the ... Show more See details	Health Resources and Services Administration	3/27/2009
NATIONAL NURSING CENTERS CONSORTIUM	$249,695	ARRA - Early Head Start Through Early Head Start ARRA Expansion the department provides funding to sub-recipients for 128 more slots through Center-based and Home-based service delivery options to pregnant women, infants and toddlers from low-income families by targeting high qu This spending item is part of a $2,540,725 allocation. See details	Administration for Children and Families	11/18/2009
FUND FOR PHILADELPHIA INC	$249,333	ARRA Strengthening Communities Fund ARRA Strengthening Communities Fund State, Local, and Tribal Government Capacity Building Program This award is made to State, city, county, and Indian/Native American Tribal governments (or organizations designated by such governments) in order to build See details	Administration for Children and Families	9/23/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$249,117	Trans-NIH Recovery Act Research Support Mycobacterial tuberculosis (Mtb) is an obligatory aerobe that causes tuberculosis. Understanding of the growth and survival mechanisms of Mtb is critical to developing new antibiotics against TB. In order to obtain energy required for various cellular a See details	National Institutes of Health	9/13/2010
CHILDRENS HOSPITAL OF PHILADELPHIA	$248,939	Trans-NIH Recovery Act Research Support With over 57,000 infants born every year in the United States with a birth weight under 1500 grams, their care is a rapidly growing public health concern. Ensuring that this high-risk group of patients receives appropriate care after discharge has become See details	National Institutes of Health	9/28/2009
RESOURCES FOR HUMAN DEVELOPMENT, INC.	$247,343	ARRA Health Center Integrated Services Development Initiative[g1] ARRA-Health Center Integrated Services Development. These grant funds are to hire or retain clinincal staff in order to expand the services of 3 health centers. The goals include serving 3,032 new patients (one third of whom are uninsnsured) in 10,422 medi... Show more See details	Health Resources and Services Administration	3/27/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$246,513	Trans-NIH Recovery Act Research Support The awarded project intends to create a new technician position for my existing RO1 award (HL088243) supported by NIH/NHLBI to accelerate the tempo of the research. The parent grant aims to elucidate the role of excessive Ca influx through the L-type calc See details	National Institutes of Health	7/16/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$246,095	Trans-NIH Recovery Act Research Support This is an administrative supplement for grant entailing studies aimed at understanding the cellular and molecular basis for diabetes and related metabolic diseases. Funds are requested to supplement 2 projects and 2 cores and will lead to 1) the creation See details	National Institutes of Health	12/28/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$246,010	Trans-NIH Recovery Act Research Support The goal of this proposal is to examine how inflammation, tissue microenvironment and regulatory T cells influence the development of long term immunity to different kinds of viruses including influenza A virus. We have examined how exposure to prolonged This spending item is part of a $488,105 allocation. See details	National Institutes of Health	7/06/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$245,642	ARRA - Scholarships for Disadvantaged Students This award provides scholarships for disadvantaged students SOM, Dental Medicine, Nursing and Social Work See details	Health Resources and Services Administration	9/03/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$245,571	Trans-NIH Recovery Act Research Support The proposed administrative supplement is to provide support for two part-time bilingual patient navigators (Vietnamese and Chinese) and pilot test our Hepatitis B patient navigation intervention program. The pilot patient navigation intervention primaril See details	National Institutes of Health	9/18/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$244,377	Trans-NIH Recovery Act Research Support The focus of this study is the genetics of variation in human gene expression. Our overall goals are to characterize the extent of variation in gene expression and to identify the genetic determinants of this variation. The specific aims for this renewal See details	National Institutes of Health	9/18/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$243,842	Trans-NIH Recovery Act Research Support Each site in the network will submit an administrative supplement to fund an additional research coordinator and sonographer to conduct secondary studies approved by the principal investigators. The studies will augment the network's original scientific p See details	National Institutes of Health	7/13/2010
PUBLIC HEALTH MANAGEMENT CORPORATION	$243,715	ARRA Health Center Integrated Services Development Initiative[g1] PHMC received an Increased Demand for Services grant for its 3 Federally Qualified Health Centers. PHMC's goals are to add evening and weekend hours in order to serve more patients; hire a nurse to see homeless patients at low demand d shelters; and hire a... Show more See details	Health Resources and Services Administration	3/27/2009
Youth Enrichment Programs Inc	$242,823	ARRA - Early Head Start Through Early Head Start ARRA Expansion the department provides funding to sub-recipients for 128 more slots through Center-based and Home-based service delivery options to pregnant women, infants and toddlers from low-income families by targeting high qu This spending item is part of a $2,540,725 allocation. See details	Administration for Children and Families	11/18/2009
COVENANT HOUSE INC	$241,720	ARRA Health Center Integrated Services Development Initiative[g1] On-site behavioral health and dental care will facilitate/enhance continuity in care and services, imporving quality assurance activities. In pediatrics this IDS will foster prevention and help diminish tooth decay which is not identifified early and severe... Show more See details	Health Resources and Services Administration	3/27/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$241,680	Trans-NIH Recovery Act Research Support Approximately 7.9 million Americans suffer from heart failure every year. Among these, nearly 2.5 million develop Ischemic Mitral Regurgitation (IMR), a 33% increase since 1995. Even with such high prevalence, little is known of the cause and progression This spending item is part of a $775,872 allocation. See details	National Institutes of Health	8/12/2009
THOMAS JEFFERSON UNIVERSITY	$240,643	Trans-NIH Recovery Act Research Support Our parent grant aims to understand the biological role and therapeutic potential of S100A1, which is released from injured cardiomycocytes, in the course of cardiac inflammation and mycardial regeneration after ischemic damage. The aim of the proposed s See details	National Institutes of Health	7/16/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$240,000	Trans-NIH Recovery Act Research Support The objective of this supplement is to provide direct evidence of the intracellular location of the G protein-coupled estrogen receptor GPR30/GPER in neurons. Despite the recent acceptance of GPR30/GPER as an estrogen receptor by the scientific community, See details	National Institutes of Health	7/16/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$239,125	Trans-NIH Recovery Act Research Support An adequate number of beta cells are required for production of a sufficient amount of insulin to maintain normoglycemia. Enhancing beta cell proliferation or regeneration can be an effective means to treat type 2 diabetes (T2D). Mutations in the multiple See details	National Institutes of Health	1/13/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$238,979	Trans-NIH Recovery Act Research Support The aim is to determine the contribution of mechanical factors (myofibroblast contractility and regional increases in liver stiffness) to the development of bridging fibrosis. The research plan includes 1) a detailed morphological analysis of fibrotic rat See details	National Institutes of Health	9/25/2009
THOMAS JEFFERSON UNIVERSITY	$238,964	Trans-NIH Recovery Act Research Support We hypothesize that mice lacking arrestin-2 will have defects in thrombus formation in vivo, particularly in models that are selectively thrombin-dependent. Supplementary Aim I is to characterize thrombus formation in arrestin2-/- mice in thrombin-depend See details	National Institutes of Health	8/01/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$236,748	ARRA - Prevention and Wellness--Communities Putting Prevention to Work This past quarter, PhiladelphiaG??s CPPW was able to make great strides in in completing its main tobacco control objectives. An executive order made 183 recreation centers, playgrounds, and outdoor pools smoke-free, affecting ovever 3.7 million visits. New... Show more This spending item is part of a $10,356,927 allocation. See details	Centers for Disease Control and Prevention	3/19/2010
CHILDRENS HOSPITAL OF PHILADELPHIA	$234,823	Trans-NIH Recovery Act Research Support Project Summary: The immunological synapse (IS) is the dynamic interface between an immune cell and the cell that it is recognizing. A major function of the IS is directed secretion, which allows specific targeting of immune effector function. Our long-te See details	National Institutes of Health	7/17/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$232,392	Trans-NIH Recovery Act Research Support Nanotechnology for Multiplexed and Intraoperative Cancer Detection; This grant application aims to develop new and innovative technologies for applications in cancer surgery. The main goals are to help the surgeon to delineate tumor margins, to identify This spending item is part of a $1,998,560 allocation. See details	National Institutes of Health	9/30/2009
THOMAS JEFFERSON UNIVERSITY	$232,000	Trans-NIH Recovery Act Research Support Arsenic is widely spread in the environment such as soil, minerals, smoke, contaminated air and water. Epidemiologic studies showed that inorganic arsenic exposure induced lung, skin, liver, and bladder cancers. However, the etiology and molecular mechan See details	National Institutes of Health	8/25/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$231,877	Trans-NIH Recovery Act Research Support This project will help improve a method to genetically alter human embryonic stem cells in order to faithfully and easily measure the activity of several heart specific genes. This method, called gene targeting, will greatly facilitate development of pr This spending item is part of a $492,990 allocation. See details	National Institutes of Health	8/14/2009
THE INSTITUTE FOR CANCER RESEARCH	$229,307	Trans-NIH Recovery Act Research Support The parent award, R01 GM083025 G?Specificity of Effector Activation by Rho Family GTPasesG?, seeks to elucidate mechanisms regulating the activation of immediate downstream effectors of the Rho family GTPases Rac and Cdc42. Central to the proposed aims is See details	National Institutes of Health	9/30/2009
PHILADELPHIA COLLEGE OF OSTEOPATHIC MEDICINE	$228,124	Trans-NIH Recovery Act Research Support Infection associated with allograft transplantation and prosthesis use can occur in any patient, and is particularly prevalent and challenging in immunocompromised individuals. When developed, infection can lead to prolonged disability with immense psycho This spending item is part of a $875,280 allocation. See details	National Institutes of Health	9/17/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$227,500	Trans-NIH Recovery Act Research Support Clinical and translational science is a major focus for the University of Pennsylvania (Penn) and Children's' Hospital of Philadelphia (CHOP). Indeed, the Penn/CHOP CTSA has catalyzed major institutional investments in translational research through the I See details	National Institutes of Health	4/22/2010
AMERICAN COLLEGE OF RADIOLOGY, THE	$226,830	Trans-NIH Recovery Act Research Support The Radiation Therapy Oncology Group (RTOG), which is one of the largest and most established cooperative groups in oncology, has developed a recursive partitioning analysis (RPA) model for malignant glioma patients, using primarily clinical and demograph This spending item is part of a $2,056,531 allocation. See details	National Institutes of Health	9/29/2009
SPECTRUM HEALTH SERVICES, INC.	$226,643	ARRA Health Center Integrated Services Development Initiative[g1] In response to the Increased Demand Initiative, Spectrum Health Services, Inc.(Spectrum) will focus on three major efforts: increasing the number of patients from growing ethnic at-risks in North and West Philadelphia, hiring a obstetrtrician-gynecologist, ... Show more See details	Health Resources and Services Administration	3/23/2009
UNIVERSITY OF THE SCIENCES IN PHILADELPHIA	$223,780	Trans-NIH Recovery Act Research Support The long-term goal of this investigation is to research and develop a novel macromolecular delivery system for anticancer drugs to produce greater anti tumor efficacy and less toxicities compared to non-biodegradable polymer delivery systems as well as to See details	National Institutes of Health	5/12/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$223,568	Trans-NIH Recovery Act Research Support Chronic inflammation is a debilitating and potentially life threatening condition that occurs in a number of diseases. Cells of the blood vessel walls control chronic inflammation by allowing the recruitment the immune cells from the blood into tissues. T See details	National Institutes of Health	7/16/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$223,549	Trans-NIH Recovery Act Research Support The project allows the team to focus in depth on the analysis and computer automation aspects of the research project. Briefly, the R01 project includes complex MRI experiments designed to obtain images and physiological data in lean, middleweight and obe See details	National Institutes of Health	7/17/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$223,416	Trans-NIH Recovery Act Research Support This competitive revision proposes to expand the scopeof work in the project R01GM083272 entitled Mechanical control of cell growth and differentiation that isdirected at understanding cellular mechanosensing. Aim 1 of this revision builds on preliminary See details	National Institutes of Health	9/30/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$222,232	Trans-NIH Recovery Act Research Support Patients with an acute coronary syndrome (ACS) and comorbid depression have a 2-fold higher risk for recurrent ACS and mortality, worse quality of life, and higher costs of care than nondepressed ACS patients. The strength of these findings prompted the A This spending item is part of a $4,136,888 allocation. See details	National Institutes of Health	9/28/2009
PHILADELPHIA CORPORATION FOR AGING	$218,369	Aging Congregate Nutrition Services for States The American Recovery and Reinvestment Act (ARRA) provided funding for congregate nutrition services. Established in 1972 under the Older Americans Act, the program provides meals to older Americans in congregate facilities such as senior centers, adultlt ... Show more This spending item is part of a $3,005,971 allocation. See details	Administration on Aging	3/18/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$217,883	Trans-NIH Recovery Act Research Support Patients with defective enamel often have prolonged clinical treatments, pain and social anxiety because of the appearance of their teeth. This proposal represents a collaborative effort between clinical and basic science researchers, with the goal of pla See details	National Institutes of Health	9/01/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$214,295	Trans-NIH Recovery Act Research Support This proposal seeks an administrative supplement to support the hiring of an additional study coordinator to enhance patient recruitment, collection of DNA, Plasma, and genotyping of patients in the Penn Heart Failure Study. This will allow us to achieve See details	National Institutes of Health	7/13/2009
PHILADELPHIA, CITY OF	$212,733	ARRA - Immunization The Philadelphia Department of Public Health (PDPH) Immunization Program has operated an Immunization Information System (IIS) known as KIDS since 1993. KIDS informs over 1,000 health care providers in the city about required and missing immunizations fo This spending item is part of a $912,733 allocation. See details	Centers for Disease Control and Prevention	9/01/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$212,625	Trans-NIH Recovery Act Research Support The goal of this proposal is to delineate the viral genes that lead to severe acute respiratory syndrome (SARS) utilizing a novel rodent model of SARS. SARS infected over 8,000 persons globally with over 700 deaths. We propose to use a MHV-1 infected mous This spending item is part of a $421,918 allocation. See details	National Institutes of Health	5/21/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$211,690	Trans-NIH Recovery Act Research Support The goal of this administrative supplement is to address the contribution of phosphatase activity to regulation of kinetochore microtubule interactions in mitosis. The proposed experiments are a direct outgrowth of experiments that were conducted as part See details	National Institutes of Health	8/31/2009
UNIVERSITY OF THE SCIENCES IN PHILADELPHIA	$211,159	Trans-NIH Recovery Act Research Support The 2,4-thiazolidinedione (TZD) ring is found in currently marketed and investigational therapeutic agents. This is a potential human health concern since hepatotoxicity was reported in some patients taking TZD ring containing drugs. An example of this is See details	National Institutes of Health	5/13/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$208,387	Trans-NIH Recovery Act Research Support Although the brain is an immune privileged site, adaptive immunity can provide resistance to various infectious diseases that affect the CMS. This is illustrated by the important role that T cells play in resistance to Toxoplasmic encephalitis (TE) which See details	National Institutes of Health	9/21/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$207,542	Trans-NIH Recovery Act Research Support This proposal seeks to determine the feasibility of targeted therapy against the autoantibodies that cause the blistering in this disease. We will screen pharmacological compounds and other small molecules, that could potentially be developed into drugs, See details	National Institutes of Health	9/18/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$207,535	Trans-NIH Recovery Act Research Support This supplemental application requests scientific computing and personnel resources for two (2) NIDDK sponsored research projects. This two year supplemental request is intended to support the Data Coordinating Centers for two (2) NIDDK sponsored U01s: th This spending item is part of a $400,047 allocation. See details	National Institutes of Health	9/27/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$205,151	Trans-NIH Recovery Act Research Support Long projection axons regenerate poorly through the damaged central nervous system. One key reason is the environment through which they must re grow contains many biochemical signals that trigger signaling pathways which inhibit axon outgrowth. Some of t See details	National Institutes of Health	9/21/2009
Adult Congenital Heart Association	$204,850	Trans-NIH Recovery Act Research Support Objectives: To create the IT, data-sharing, education, and oversight tools necessary for a patient-driven, national adult congenital heart disease research network. Aims: (1) To demonstrate the feasibility of a patient-centered research model for patients This spending item is part of a $996,091 allocation. See details	National Institutes of Health	7/20/2010
UNIVERSITY OF THE SCIENCES IN PHILADELPHIA	$203,790	ARRA - Scholarships for Disadvantaged Students This award is the Scholarships for Disadvantaged Students funded with ARRA monies. The purpose of this award is to provide grant funding to assist students from disadvantaged backgrounds to pay tuition and fees. These students may either come from an n e... Show more See details	Health Resources and Services Administration	6/14/2010
PUBLIC HEALTH MANAGEMENT CORPORATION	$201,853	ARRA - Prevention and Wellness--Communities Putting Prevention to Work This past quarter, PhiladelphiaG??s CPPW was able to make great strides in in completing its main tobacco control objectives. An executive order made 183 recreation centers, playgrounds, and outdoor pools smoke-free, affecting ovever 3.7 million visits. New... Show more This spending item is part of a $10,356,927 allocation. See details	Centers for Disease Control and Prevention	3/19/2010
TEMPLE UNIVERSITY	$201,023	ARRA - Scholarships for Disadvantaged Students Scholarships for Disadvantaged Students (SDS) for Medical, Dental, Pharmacy and Baccalaureate Nursing students. See details	Health Resources and Services Administration	9/03/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$200,744	Trans-NIH Recovery Act Research Support Our currently funded studies from NINDS were designed to test the overall hypothesis that rapid rotations of the immature brain (as associated often with abuse, motor vehicle accidents and falls) produce brain injury via both mechanical and biochemical si See details	National Institutes of Health	8/17/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$200,559	Trans-NIH Recovery Act Research Support Despite decades of research, a limiting obstacle to personalizing oncology is identifying correlates of response against a diverse genetic background. For individuals with rare subtypes of human cancers where minimal data exists, this problem is compounde This spending item is part of a $4,269,212 allocation. See details	National Institutes of Health	9/29/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$200,000	Trans-NIH Recovery Act Research Support The goals of this administrative supplement that will be accomplished within two years are to obtain a complete in vivo temporal gene expression map during Vibrio cholerae infection of an animal model. The proposed experiments are a direct outgrowth of ex See details	National Institutes of Health	9/17/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$199,997	Trans-NIH Recovery Act Research Support This is an ARRA competitive revision of P30-NR005043 Center for Nursing Outcomes Research. We seek to extend the scope of the parent grant to create a new interdisciplinary collaboration with the Cartographic Modeling Laboratory (CML) and investigators i See details	National Institutes of Health	9/18/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$199,316	Trans-NIH Recovery Act Research Support The goal of this ARRA application is to accelerate the pace of the current scope of the PENN Udall Center while adding retaining jobs. Briefly, the goals of this Udall Center are to elucidate mechanisms of brain degeneration in patients with Parkinson s d See details	National Institutes of Health	9/25/2009
P'UNK AVENUE LLC	$197,425	Trans-NIH Recovery Act Research Support This project proposes to test a novel strategy financial incentives to improve uptake of comparative effectiveness findings among physicians and patients to reduce cardiovascular risk. This project will focus on improving cholesterol control among This spending item is part of a $12,488,763 allocation. See details	National Institutes of Health	9/16/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$197,182	Trans-NIH Recovery Act Research Support The studies described have great relevance to public health. Spermatogonial stem cells are at the foundation of the continual production throughout life of sperm in all males, including humans. Therefore, the function and normal activity of these stem c See details	National Institutes of Health	9/28/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$196,269	Trans-NIH Recovery Act Research Support This is an administrative supplement to the parent R01. We propose to study a refined approach for quantification of contractile function of the heart. The supplement is expected to increase the tempo of scientific research and create one job position. See details	National Institutes of Health	7/16/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$195,769	Trans-NIH Recovery Act Research Support Diagnostic gene expression profiles were first identified ten years ago to identify subsets of childhood leukemia. Since then, untold thousands of studies (2909 listed in PubMed using G??cancer diagnosis microarraysG??) have been published purporting to b This spending item is part of a $2,862,111 allocation. See details	National Institutes of Health	9/29/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$194,671	Trans-NIH Recovery Act Research Support This project will have the dual impact of job creation and scientific advancement in the critically important yet underserved area of TBI. Such information is critical to provide important insight into the mechanisms underlying the persistent cognitive de See details	National Institutes of Health	8/17/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$193,792	ARRA - Prevention and Wellness--Communities Putting Prevention to Work PhiladelphiaG??s nutrition and physical activity challenges are daunting: nearly half of children are overweight or obese, low-income communities have little access to healthy foods, and opportunities for physical activity in schohools, neighborhoods, and w... Show more This spending item is part of a $15,018,277 allocation. See details	Centers for Disease Control and Prevention	3/19/2010
PHILADELPHIA CORPORATION FOR AGING	$193,181	ARRA - Communities Putting Prevention to Work: Chronic Disease Self-Manage In collaboration with the American Recovery and Reinvestment Act (ARRA)-funded Communities Putting Prevention to Work (CPPW) program, this ARRA funding will support the deployment of evidence-based chronic disease self-managemement programs (CDSMP) that emp... Show more This spending item is part of a $1,000,000 allocation. See details	Administration on Aging	3/26/2010
THOMAS JEFFERSON UNIVERSITY	$193,125	Trans-NIH Recovery Act Research Support Our Preliminary Data show that hypertrophic chondrocytes do in fact express CHOP, an important UPR target protein that has a prominent role in ER stress-induced apoptosis. We found also that pre-hypertrophic chondrocytes express Bip, a chaperon protein th See details	National Institutes of Health	9/24/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$192,440	Trans-NIH Recovery Act Research Support The overall goal of this application is to discover and validate multiple novel plasma protein biomarkers of human ovarian cancer. We will initially discover a substantial number of candidate biomarkers through parallel analysis of two complementary model This spending item is part of a $993,896 allocation. See details	National Institutes of Health	6/29/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$190,316	Trans-NIH Recovery Act Research Support We propose to perform DNA resequencing collected cohorts with extreme lipid phenoptypes (elevated LDL-C, triglycerides and HDL-C). We will resequence areas of the genome that have been identified as potential loci affecting lipid traits in genome wide ass This spending item is part of a $1,000,000 allocation. See details	National Institutes of Health	9/21/2009
WHYY, INC.	$190,073	ARRA - Prevention and Wellness--Communities Putting Prevention to Work PhiladelphiaG??s nutrition and physical activity challenges are daunting: nearly half of children are overweight or obese, low-income communities have little access to healthy foods, and opportunities for physical activity in schohools, neighborhoods, and w... Show more This spending item is part of a $15,018,277 allocation. See details	Centers for Disease Control and Prevention	3/19/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$188,774	Trans-NIH Recovery Act Research Support The proposed project is an extension of the ongoing parent project, and will investigate the effect of reduced cigarette nicotine content in menthol cigarette smokers. The project will provide important data on behavior and use patterns and toxin biomark See details	National Institutes of Health	8/19/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$188,406	Trans-NIH Recovery Act Research Support The goal of this project is to develop a software tool kit (based on the XIP application from Siemens corporation) that will allow scientists to study prostate cancer by combining data from multiple imaging modalities (radiology and pathology) with molec This spending item is part of a $1,354,140 allocation. See details	National Institutes of Health	7/16/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$187,582	Trans-NIH Recovery Act Research Support This two year administrative supplement will focus on aspects of EnvZ OmpR signaling and other two component signaling systems that are a direct outgrowth of the work of the parent grant. The first aim will determine the variability in properties of the E See details	National Institutes of Health	8/14/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$185,716	Trans-NIH Recovery Act Research Support Funding is being requested for additional tasks within the scope of the parent grant. Under the Proposed Task 1, we will extend specific aim 1 to incorporate epigenomic marks as a potential mediator of expression divergence among paralogs. Under the Propo See details	National Institutes of Health	9/09/2009
THE INSTITUTE FOR CANCER RESEARCH	$184,500	Trans-NIH Recovery Act Research Support Title: R01 NS060701 Intra- and Inter-Neuronal viral Trafficking. Abstract and Specific Aims: Supplemental funds provide support for one new full-time postdoctoral fellow. The parent grant for this request has two main research objectives, both of whic See details	National Institutes of Health	8/20/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$183,297	Trans-NIH Recovery Act Research Support This research focuses on two common problems that many women experience as they go through menopause, hot flashes and poor sleep. We are interested in how hot flashes affect a woman s sleep quality and whether women who have more hot flashes have poorer s See details	National Institutes of Health	7/16/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$182,814	Trans-NIH Recovery Act Research Support The Cardiovascular Effects of Obstructive Sleep Apnea (COSA) study is a randomized trial funded by NHLBI through grant 5R01HL80076 , in which 195 adults with obesity (BMI30 kg m2), moderate to severe obstructive sleep apnea (apnea hypopnea index 15), and See details	National Institutes of Health	7/16/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$178,400	Trans-NIH Recovery Act Research Support Chronic kidney disease (CKD) and its metabolic derangements substantially affect the well-being of children. In order to define the nature, magnitude, and temporal evolution of the adverse effects of progressive CKD, we propose to extend the follow-up of This spending item is part of a $329,400 allocation. See details	National Institutes of Health	6/11/2010
THOMAS JEFFERSON UNIVERSITY	$178,063	Trans-NIH Recovery Act Research Support Liver injury due to prescription and non-prescription medication use is an important public health problem. Drug-induced liver injury (DILI) is the most common reason for adverse actions taken on drugs by the Food and Drug Administration. Detection of DIL See details	National Institutes of Health	9/29/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$176,539	Trans-NIH Recovery Act Research Support The specific aims of the parental grant are to create novel switches while exploring the molecular basis of protein DNA recognition and allosteric signaling as it relates to gene regulation. We proposed to approach this problem by using a directed evoluti See details	National Institutes of Health	9/24/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$176,213	Trans-NIH Recovery Act Research Support Specific Aims: Acute Lung Injury (ALI) is a common complication of sepsis and trauma and is associated with mortality of over 20%. Candidate gene studies suggest a role for common genetic variation in determining host susceptibility to ALI in critically This spending item is part of a $4,676,664 allocation. See details	National Institutes of Health	9/25/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$175,927	Trans-NIH Recovery Act Research Support The purpose of this administrative supplement is to stimulate basic and translational research into the neurobiological substrates of social behavior, thus providing greater insight into the mechanisms of psychiatric disorders with known deficits in socia See details	National Institutes of Health	9/28/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$175,685	Trans-NIH Recovery Act Research Support Patient recruitment and retention Patient recruitment and retention of study subjects has been excellent in this study. The COMET Network was able to screen 108 potential subjects. From these there were 12 screen fails, 3 subjects withdrew consent, two This spending item is part of a $7,915,507 allocation. See details	National Institutes of Health	9/28/2009
THOMAS JEFFERSON UNIVERSITY	$174,955	Trans-NIH Recovery Act Research Support The importance of imaging small animals in basic and translational biomedical research, with such modalities as PET, SPECT, CT, optical, ultrasound, and MRI, cannot be over- emphasized. The ability to image small animals without sacrificing them, allows i See details	National Institutes of Health	3/04/2010
FOX CHASE CANCER CENTER	$174,459	Trans-NIH Recovery Act Research Support The incidence of esophageal adenocarcinoma (EAC) in the United States is increasing markedly. Five-year survival remains a disappointing 15%. Better methods are urgently needed to detect patients at high risk of EAC and to interrupt disease progression. I See details	National Institutes of Health	5/29/2009
Concilio	$173,904	ARRA - Prevention and Wellness--Communities Putting Prevention to Work This past quarter, PhiladelphiaG??s CPPW was able to make great strides in in completing its main tobacco control objectives. An executive order made 183 recreation centers, playgrounds, and outdoor pools smoke-free, affecting ovever 3.7 million visits. New... Show more This spending item is part of a $10,356,927 allocation. See details	Centers for Disease Control and Prevention	3/19/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$171,947	Trans-NIH Recovery Act Research Support This supplement will be used to conduct additional analyses relevant to the aims of the parent grant. we propose to address the following questions: 1) How do healthcare and education services complement or substitute for each other in different jurisdict See details	National Institutes of Health	7/22/2009
INTEGRAL MOLECULAR, INC	$171,804	Trans-NIH Recovery Act Research Support Understanding the precise molecular interactions between drugs and their targets, their structure-activity relationship (SAR), is a highly desirable goal during drug development. GPCRs are the single largest family of drug targets in the pharmaceutical in See details	National Institutes of Health	9/24/2009
DREXEL UNIVERSITY	$171,044	ARRA Accelerating Adoption of Comparative Effectiveness Research (CER) The Agency for Healthcare Research and Quality and the Institute of Medicine have called for the adoption of improved handoff tools and processes to address the high incidence of harmful communication failures in hospitals. Compararative effectiveness resea... Show more This spending item is part of a $2,993,464 allocation. See details	National Institutes of Health	9/21/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$170,848	Trans-NIH Recovery Act Research Support The goal of this ARRA project is to develop a multivariate quantitative template of the developing brain. The template will be openly available to all and will be used to enumerate the interaction between working memory performance and cortical and connec This spending item is part of a $456,523 allocation. See details	National Institutes of Health	5/12/2011
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$170,374	Trans-NIH Recovery Act Research Support The goal of the supplement is to increase and extend our progress on the specific aims described in HL 078726. Specifically, additional labor is needed to speed the animal work examining the in vivo atherosclerotic properties of Platelet Factor 4 (PF4) d See details	National Institutes of Health	8/01/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$169,634	Trans-NIH Recovery Act Research Support An estimated two billion people worldwide are infected with soil transmitted helminth parasites. Although there is strong evidence that T helper type 2 (Th2) cytokines are critical for immunity to infection, the early events that promote protective Th2 c See details	National Institutes of Health	4/19/2010
DREXEL UNIVERSITY	$167,925	Trans-NIH Recovery Act Research Support This is a request to supplement our parent award, which is to discover and develop biomarkers for the early detection of liver cancer and hepatitis, with funds from American Recovery and Reinvestment Act as in NOT-OD-09-056. In the parent grant progress, See details	National Institutes of Health	8/01/2009
THOMAS JEFFERSON UNIVERSITY	$167,202	The Cancer Knowledge Cloud will connect and share information generated through NCI genomic atlas projects, the caHUB tissue acquisition network, the NCI functional Biology Consortium, NCI patient Characterization Center, the NCI pre-clinical Development This spending item is part of a $103,000,000 allocation. See details	National Institutes of Health	11/23/2009
THE CHILDREN'S HOSPITAL OF PHILADELPHIA	$164,500	Trans-NIH Recovery Act Research Support The overall aim of this proposal is to elucidate the mechanism(s) regulating hepatic urea synthesis in case of nonalcoholic fatty liver disease (NAFLD) or metabolic syndrome. The long-term goal is to develop a clinically applicable protocol to improve ure See details	National Institutes of Health	6/08/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$164,500	Trans-NIH Recovery Act Research Support Every person differs in his or her response to pathogens and in the likelihood that they will suffer from complex diseases such as cancer, heart disease or diabetes. Individual susceptibility to disease is determined in part by genetics, and we can map wi This spending item is part of a $1,500,000 allocation. See details	National Institutes of Health	9/25/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$163,385	Trans-NIH Recovery Act Research Support The aims of this supplement are to to determine if genetic variation in thromboxane synthase, ET-1, or Rho-kinase determine six minute walk distance and response to therapy in PAH. Samples are undergoing genetic and statistical analysis currently.The See details	National Institutes of Health	7/16/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$162,803	Trans-NIH Recovery Act Research Support Center for Experimental Neurorehabilitation Training (CENT)- This grant is designed to enhance the parent project's mission to promote research in the field of neurorehabilitation by providing technology that could improve research at a very basic level. See details	National Institutes of Health	7/21/2010
CENTER IN THE PARK INC	$162,448	Trans-NIH Recovery Act Research Support This application addresses the broad Challenge Area (05) Comparative Effectiveness Research and specific Challenge Topic, 05-MH-102*: Cost Effectiveness of Mental Health Interventions. We propose a two year initiative to add a cost and outcome component This spending item is part of a $997,110 allocation. See details	National Institutes of Health	9/29/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$162,418	Trans-NIH Recovery Act Research Support This project was a supplement that evaluated the role of microbial translocation and potential co pathogens in early immune recovery and clinical outcomes after HAART initiation in adults with HIV and active tuberculosis in Botswana. See details	National Institutes of Health	3/22/2010
PUBLIC HEALTH MANAGEMENT CORPORATION	$162,212	ARRA ?Health Information Technology and Public Health The Division of Disease Control (DDC) is the recipient of Epidemiology and Laboratory Capacity (ELC) Cooperative Agreement award for the Philadelphia Department of Public Health (PDPH), and therefore, will be the executive sponsor of this project.t. The Div... Show more This spending item is part of a $252,752 allocation. See details	Centers for Disease Control and Prevention	8/02/2010
CHILDRENS HOSPITAL OF PHILADELPHIA	$162,202	Trans-NIH Recovery Act Research Support The overall objective of this application is to develop an integrated biomedical-computing infrastructure incorporating audiologic, otologic and genetic patient data that will meet the needs of investigators pursuing patient-oriented pediatric hearing res See details	National Institutes of Health	7/17/2009
KEN-CREST SERVICES	$161,188	ARRA - Head Start This award provides for ARRA Cost of Living Adjustment (COLA) and Quality Improvement Funding consistent with the provisions of Section 640(a)(5) of the Head Start Act for the Head Start program. Head Start promotes the school readiness of low-income chil This spending item is part of a $3,033,980 allocation. See details	Administration for Children and Families	6/17/2009
MONELL CHEMICAL SENSES CENTER	$161,089	Trans-NIH Recovery Act Research Support Odor information is encoded by selective activation of olfactory receptors and mapped topographically to glomeruli in the olfactory bulb. Our broad, long term objective is to understand dendritic and synaptic signaling mechanisms in the bulb that transfor See details	National Institutes of Health	7/15/2009
WISTAR INSTITUTE OF ANATOMY & BIOLOGY	$160,609	Trans-NIH Recovery Act Research Support The PI's previous work unveiled a novel mechanism of vascularization in human and mouse ovarian carcinoma: beta-defensins were shown to massively recruit CD45+CD11c+CCR6+ myeloid cells to the tumor microenvironment, where they were transformed by VEGF in See details	National Institutes of Health	5/25/2011
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$160,234	Trans-NIH Recovery Act Research Support Specific Aims: Acute Lung Injury (ALI) is a common complication of sepsis and trauma and is associated with mortality of over 20%. Candidate gene studies suggest a role for common genetic variation in determining host susceptibility to ALI in critically This spending item is part of a $4,676,664 allocation. See details	National Institutes of Health	9/25/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$159,584	Trans-NIH Recovery Act Research Support This project will address the role of adenovirus infection in the pathogenesis of asthma and cystic fibrosis See details	National Institutes of Health	9/01/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$159,584	Trans-NIH Recovery Act Research Support The proposed study examines outcomes for injured children in the United States. The investigators will use nationally representative datasets to compare severity adjusted outcomes for children treated at pediatric trauma centers, adult trauma centers, an See details	National Institutes of Health	8/27/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$158,342	Trans-NIH Recovery Act Research Support The overall goal of this application is to define the factors that shape antiviral T and B cell immunity and delineate the mechanisms by which these factors operate. We have focused on three factors that could shape effector and memory lymphocyte differen This spending item is part of a $161,177 allocation. See details	National Institutes of Health	9/21/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$158,258	Trans-NIH Recovery Act Research Support The epithelial to mesenchymal transition (EMT) is a fundamental developmental process that can be reactivated in epithelial cancers to promote tumor invasion and metastasis. The ESRPs are master regulators of an epithelial splicing program and a comprehen See details	National Institutes of Health	7/02/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$158,049	Trans-NIH Recovery Act Research Support Mucopolysaccharidosis I (MPS I) and MPS VII are lysosomal storage diseases in which glycosaminoglycans (GAG) accumulate due to deficient activity in alpha-L-iduronidase and beta-glucuronidase, respectively. This results in multisystemic disease involving This spending item is part of a $780,579 allocation. See details	National Institutes of Health	8/27/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$156,976	Trans-NIH Recovery Act Research Support This proposal seeks to elucidate the molecular pathways responsible for diaphragm fiber atrophy and decreased diaphragm force generation in patients exposed to the combination of diaphragm inactivity and mechanical ventilation. See details	National Institutes of Health	7/16/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$155,813	Trans-NIH Recovery Act Research Support This ARRA supplement under the parent U01 grant was funded to expand the original parent U01 scope of work. Based on our earlier meetings with NIMH and the US Army, the focus of this study was expanded in five ways: (i) the range of outcomes assessed; (i This spending item is part of a $10,000,000 allocation. See details	National Institutes of Health	9/30/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$155,780	Trans-NIH Recovery Act Research Support Regulatory T cells are crucial for the control of immune-mediated pathology during organ transplant rejection and autoimmune disease, therefore understanding the underlying mechanisms by which these cells function will be critical for promoting immune tol See details	National Institutes of Health	7/17/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$154,941	Trans-NIH Recovery Act Research Support Our proposed studies over tthe funding period of this ARRA Supplement Award will provide a more detailed understanding of how Daam1 regulates gastrulation and neural tube closure which is the major aim of our parental RO1 grant and an area of study that r See details	National Institutes of Health	3/12/2010
MONELL CHEMICAL SENSES CENTER	$154,634	Trans-NIH Recovery Act Research Support This is an Administrative Supplement to grant: NIH RO1GrantHD37119, Model for Sensitive Periods in Early Flavor Learning. The overall goal of the grant is to discover the timing of the sensitive period in human flavor learning and its impact on later foo See details	National Institutes of Health	7/27/2010
THOMAS JEFFERSON UNIVERSITY	$154,500	Trans-NIH Recovery Act Research Support This administrative supplement supports a new pilot funding program in Translational Cancer Medicine that will effectively leverage scientific activities within the research programs of the Kimmel Cancer Center. As with many Cancer Centers, a key rate-li See details	National Institutes of Health	9/22/2009
ESPERANZA HEALTH CENTER, INC.	$154,142	ARRA Health Center Integrated Services Development Initiative[g1] The purpose of this award is to expand access to needed primary health care services specifically by expanding services at existing health center sites in and underserved area. See details	Health Resources and Services Administration	3/27/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$153,946	Trans-NIH Recovery Act Research Support The goal of the administrative supplement project is to determine how the catalytic activity of bacterial ribonuclease III is regulated by YmdB protein. RNase III is a double-stranded(ds) specific phosphodiesterase that is highly conserved in bacteria, a See details	National Institutes of Health	7/09/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$153,563	Trans-NIH Recovery Act Research Support The new personnel continue to be involved in Project 2 by performing TBI in swine, performing MRI and biomarker data collection and performing extensive histopathological analyses. They will interface with the other projects and cores of the Program for a See details	National Institutes of Health	9/24/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$150,840	Trans-NIH Recovery Act Research Support Depression is one of the most prevalent and debilitating of the psychiatric disorders. By yielding estimates of the benefit of adding psychotherapy to medication therapy in the treatment of depression, and identifying subgroups of patients who most benefi See details	National Institutes of Health	9/23/2010
CHILDRENS HOSPITAL OF PHILADELPHIA	$150,415	Trans-NIH Recovery Act Research Support This proposal requests funds for the acquisition of a Meso Scale Discovery SECTOR 6000 Imager for the detection of biomarkers by direct sandwich immunoassay in single and multiplex formats. The Meso Scale Discovery biomarker detection technology is based See details	National Institutes of Health	7/15/2010
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$150,000	Trans-NIH Recovery Act Research Support The specific Aim of this 2 year project is to characterize the UPR induced by CS in several lung cells involved in the pathogenesis of COPD, i.e., airway epithelial cells and alveolar pneumocytes. We will test the hypotheses that: 1) the UPR response to See details	National Institutes of Health	5/08/2009
WISTAR INSTITUTE OF ANATOMY & BIOLOGY	$150,000	Trans-NIH Recovery Act Research Support This project's goal is to use a well-characterized model system to define processes governing the formation and activity of CD4+CD25+Foxp3+ regulatory T (Treg) cells. The proposal will make use of existing lineages of transgenic mice expressing the influe See details	National Institutes of Health	9/21/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$150,000	Trans-NIH Recovery Act Research Support Colorectal cancer is a preventable yet highly prevalent disease worldwide. Poor patient compliance with screening procedures increases the mortality due to colorectal cancer. There is an urgent need for chemopreventive measures for this tumor type. One of See details	National Institutes of Health	5/21/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$150,000	Trans-NIH Recovery Act Research Support Nanotechnology for Multiplexed and Intraoperative Cancer Detection; This grant application aims to develop new and innovative technologies for applications in cancer surgery. The main goals are to help the surgeon to delineate tumor margins, to identify This spending item is part of a $1,998,560 allocation. See details	National Institutes of Health	9/30/2009
PUBLIC HEALTH MANAGEMENT CORPORATION	$150,000	ARRA - Immunization The Philadelphia Department of Public Health (PDPH) in collaboration with the Centers for Disease Control and Prevention (CDC) will conduct a matched, case-control study to examine the incremental effectiveness of the 2-dose varicella vaccination regimen See details	Centers for Disease Control and Prevention	9/15/2009
WISTAR INSTITUTE OF ANATOMY & BIOLOGY	$149,767	Trans-NIH Recovery Act Research Support The goal of this proposal is to examine how inflammation, tissue microenvironment and regulatory T cells influence the development of long term immunity to different kinds of viruses including influenza A virus. We have examined how exposure to prolonged This spending item is part of a $488,105 allocation. See details	National Institutes of Health	7/06/2010
CHILDRENS HOSPITAL OF PHILADELPHIA	$149,593	Trans-NIH Recovery Act Research Support The overall goal of this application is to ensure the continued success of the Biliary Atresia Research Consortium (BARC) and the Cholestatic Liver Consortium (CLiC). Through a coordinated effort, investigations of eight cholestatic pediatric disorders wi See details	National Institutes of Health	1/31/2010
CHILDRENS HOSPITAL OF PHILADELPHIA	$149,432	Trans-NIH Recovery Act Research Support The clinical profiles of several developmental disorders, including autism spectrum disorders (ASD), involve varying degrees of comorbid language impairment (LI). Clinical diagnosis of LI, however, does not itself identify the associated underlying neuron See details	National Institutes of Health	7/17/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$149,341	Trans-NIH Recovery Act Research Support Supplemental funds are requested to develop improved apparatus and to hire a post doctoral fellow. These improved apparatus will enhance the quality of the data we collect to achieve the specific aims of the fundedparent grant, and hiring an additional po See details	National Institutes of Health	9/30/2009
THOMAS JEFFERSON UNIVERSITY	$148,739	Trans-NIH Recovery Act Research Support This Administrative Supplement has the direct goal of employing two research technicians, preferentially recent graduates with Masters degrees or equivalent, to facilitate important progress on Aim 3 of the parental grant. Their focus will specifically b See details	National Institutes of Health	9/15/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$148,734	ARRA - Prevention and Wellness--Communities Putting Prevention to Work This past quarter, PhiladelphiaG??s CPPW was able to make great strides in in completing its main tobacco control objectives. An executive order made 183 recreation centers, playgrounds, and outdoor pools smoke-free, affecting ovever 3.7 million visits. New... Show more This spending item is part of a $10,356,927 allocation. See details	Centers for Disease Control and Prevention	3/19/2010
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$148,527	Trans-NIH Recovery Act Research Support The Gastroparesis Clinical Research Consortium (GpCRC) is sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to focus on the etiology, natural history, and therapy of gastroparesis. The goal of this consortium is to See details	National Institutes of Health	9/18/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$147,772	Trans-NIH Recovery Act Research Support This research project help us to understand how anesthesia cause neurodegeneration and cognitive dysfunction by disruption of intracellular calcium homeostasis, especially abnormal calcium release from the ER and then calcium influx from extracellular spa See details	National Institutes of Health	9/25/2009
THE INSTITUTE FOR CANCER RESEARCH	$147,525	Trans-NIH Recovery Act Research Support Title G?? The porphobilinogen synthase family. Abstract G?? Porphobilinogen synthase (PBGS) catalyzes the first common step in the biosynthesis of the tetrapyrrole pigments such as heme and is a primary target for the environmental toxin lead (Pb2+). Aim See details	National Institutes of Health	9/07/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$145,110	Trans-NIH Recovery Act Research Support Type 1 diabetes (T1D) is an inflammatory disease of the pancreatic islets that afflicts millions of people worldwide. Although the etiological factors that trigger the disease vary, the common pathological outcome of T1D is the destruction of insulin prod See details	National Institutes of Health	4/06/2010
THOMAS JEFFERSON UNIVERSITY	$145,075	Trans-NIH Recovery Act Research Support Acccording with the AIMs of the Recovery Act Administrative Supplement, we will expand employment opportunities for postdoc fellows and predoc students which sorely missing, especially in the area of research focused on tumor microenviroment. Moreover, w See details	National Institutes of Health	9/01/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$144,616	Trans-NIH Recovery Act Research Support This is a competitive supplement in response to NOT-OD-09-058 (NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications). Diabetes is a metabolic disorder that currently affects over 180 million people worldwide. Common t See details	National Institutes of Health	12/28/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$144,478	Trans-NIH Recovery Act Research Support The goal of this administrative supplement, is to assess the biological validity of a novel hypothesis that, in the absence of genetic exchange, a population should adapt itself to extinction as the result of a strong evolutionary asymmetry in the mutatio This spending item is part of a $212,968 allocation. See details	National Institutes of Health	1/25/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$144,226	Trans-NIH Recovery Act Research Support This is a administrative supplement application for my R01ES009111 grant. It proposes to further develop methods for SNP SNP interactions and pathways based analysis of SNP data. It will support one postdoc for one year and a PhD student at partial suppor See details	National Institutes of Health	9/03/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$144,107	Trans-NIH Recovery Act Research Support This instrumentation proposal is for the Eclipse 90i Motorized Advanced Research Microscope (Nikon Instruments, Melville, NY, USA) with OSTEO 2009 Bone Biology Research System Software (BIOQUANT Image Analysis Corporation, Nashville, TN, USA). The propos See details	National Institutes of Health	5/13/2010
GYNECOLOGIC ONCOLOGY GROUP , THE	$143,341	Trans-NIH Recovery Act Research Support The Gynecologic Oncology Group (GOG) is the foremost multidisciplinary cooperative clinical trial research group devoted to the study of gynecologic malignancies. Since its inception in 1970, the GOG has been a recognized leader in the development of new See details	National Institutes of Health	9/22/2009
ALBERT EINSTEIN HEALTHCARE NETWORK	$143,272	Trans-NIH Recovery Act Research Support Administrative supplement for purposes of accelerating the tempo of research in several key areas as well as enhancing job creation and retention for investigators and support staff. This spending item is part of a $230,798 allocation. See details	National Institutes of Health	9/30/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$143,136	Trans-NIH Recovery Act Research Support The CRIC study participants are a diverse group of people with kidney disease, half of whom have diabetes. The CRIC study goals are to identify clinical factors such as blood or urine tests, or evidence of disease in other organs (heart, brain) that cont See details	National Institutes of Health	9/02/2009
DREXEL UNIVERSITY	$142,103	Trans-NIH Recovery Act Research Support The mechanical environment is critical to the structural integrity and normal function of many cell types. Altered cell mechanics can be either a cause or effect of a pathologic state. Cell mechanics are intricately coupled to cell biochemistry, yet the m See details	National Institutes of Health	5/14/2009
PEOPLE FOR PEOPLE, INC	$138,056	ARRA Child Care and Development Block Grant The American Recovery and Reinvestment Act (ARRA) Child Care and Development Fund (CCDF) funds have two mandatory earmarks, Infant/Toddler and Quality. The Infant/Toddler funds are utilized for new center-based Keystone Babies programs. Specifically, th This spending item is part of a $60,146,767 allocation. See details	Administration for Children and Families	4/09/2009
TEMPLE UNIVERSITY	$138,043	Trans-NIH Recovery Act Research Support The Klein group proposes supplemental study to accelerate the tempo of scientific research on biological membranes. This research will extend our understanding of the role of proteins (fusion peptides) in facilitating membrane fusion, a key process in tri See details	National Institutes of Health	9/25/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$137,846	Trans-NIH Recovery Act Research Support Radiological exposure from a terror event has been identified by the CDC and the Office of Homeland Security as a potential threat worthy of significant national preparedness. Little research has been done, however, to develop risk communication strategie This spending item is part of a $163,578 allocation. See details	National Institutes of Health	7/15/2009
THOMAS JEFFERSON UNIVERSITY	$137,684	Trans-NIH Recovery Act Research Support This project is designed to identify genetic variants that confer susceptibility to common forms of epilepsy including i) forms of idiopathic generalized epilepsy (IGE) such as juvenile myoclonic epilepsy (JME), childhood absence epilepsy (CAE) and idiopa This spending item is part of a $1,820,924 allocation. See details	National Institutes of Health	9/20/2009
THOMAS JEFFERSON UNIVERSITY	$137,072	Trans-NIH Recovery Act Research Support Cardiovascular disease is the number one killer of Americans, claiming over 500,000 lives annually. These deaths occur when the fibrous cap of an atherosclerotic plaque ruptures in the later stages of the disease. Current screening tests for the diagnosis This spending item is part of a $803,526 allocation. See details	National Institutes of Health	7/16/2009
DAEDALUS INNOVATIONS, LLC	$136,948	Trans-NIH Recovery Act Research Support Biomedical research continues to expand the use of detailed atomic-scale structure in developing a detailed understanding of the molecular basis for life and for disease. Tools for the identification of means for intervention at the molecular level are of See details	National Institutes of Health	9/30/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$136,775	Trans-NIH Recovery Act Research Support The overall goal of this project is to evaluate the effects of binge-type alcohol exposure on oocyte quality. There are no studies known to us that have examined the effects of binge alcohol consumption on fertility in women or any animal model, yet binge This spending item is part of a $1,265,834 allocation. See details	National Institutes of Health	9/22/2009
TEMPLE UNIVERSITY	$134,550	Trans-NIH Recovery Act Research Support This award supports acquisition of an animal neuroimaging package which will allow us to adapt a brand new state-of-the-art human 3 Tesla MRI scanner for small animal neuroimaging. We will obtain customized rat and mouse coils fully compatible with our See details	National Institutes of Health	4/28/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$134,485	Trans-NIH Recovery Act Research Support The Specific Aim of this project is: to examine effects of hyperglycemia, hyperinsulinemia and combined hyperglycemia and hyperinsulinemia on various parameters of blood coagulation in C-peptide negative patients with type 1 diabetes mellitus (T1DM). So See details	National Institutes of Health	9/18/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$134,303	Trans-NIH Recovery Act Research Support This machine could greatly facilitate DNA methylation analysis by a broad range of investigators, and would especially benefit those who are interested in human disease but are not DNA methylation experts. See details	National Institutes of Health	4/01/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$133,958	Trans-NIH Recovery Act Research Support It is the primary objective of this program to elucidate correlates of immune-mediated protection against HIV-1 infection using pre-clinical animal models. To this end, Project 1 will determine humoral and cell-mediated immune responses to an attenuated S This spending item is part of a $5,581,859 allocation. See details	National Institutes of Health	9/01/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$132,662	Trans-NIH Recovery Act Research Support An award was made though the American Recovery and Reinvestment Act of 2009 to directly address two of the Acts objectives: 1) to accelerate our achieving the IRACDA programs goal to train a next generation of researchers who will increase diversity in b See details	National Institutes of Health	8/10/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$132,355	Trans-NIH Recovery Act Research Support This instrumentation proposal is for the ElectroPuls E3000 Electrodynamic Test System (Instron Corp, Norwood, MA, USA). The proposed system will provide critical new capabilities to the Structure-Function Biomechanics Core in the Penn Center for Musculos See details	National Institutes of Health	5/13/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$130,836	Trans-NIH Recovery Act Research Support To accelerate research described in Specific Aim 2 of the parent grant, I am requesting an administrative supplement to hire and support a new Postdoctoral Fellow (Ryan Ragland, Ph.D.) for two years. Our unexpected finding that p53 absence does not rescue See details	National Institutes of Health	9/04/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$130,787	Trans-NIH Recovery Act Research Support This Administrative Supplement Request is for work within the scope of the Parent Grant, which aims to establish the cellular and synaptic mechanisms by which a defined central pattern generator (CPG) circuit is configured by integrated descending, hormon See details	National Institutes of Health	9/25/2009
PHILADELPHIA HEALTH & EDUCATION CORPORATION	$130,714	Trans-NIH Recovery Act Research Support This application responds to broad challenge grant area (04): Clinical Research & specific Challenge Topic, 04-MD-101: Enhancing Recruitment & Retention of Ethnic Minorities in Clinical Trials. Sickle cell disease (SCD) is a genetic disorder affecting pri This spending item is part of a $812,955 allocation. See details	National Institutes of Health	9/24/2009
THOMAS JEFFERSON UNIVERSITY	$130,197	Trans-NIH Recovery Act Research Support Melanoma, the most virulent form of skin cancer, is not responsive to chemotherapy. This project proposes to develop a method to sensitize melanomas to chemotherapy by selectively acidifying the cancer cells whileminimally affecting normal cells. The meth This spending item is part of a $937,439 allocation. See details	National Institutes of Health	5/21/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$129,686	Trans-NIH Recovery Act Research Support Development of a comprehensive, easily accessible public resource database of images, videos, and animations of cells from a variety of organisms, including both cell architecture and intracellular functionalities, as well as stimulate the economy through This spending item is part of a $2,490,729 allocation. See details	National Institutes of Health	9/30/2009
THOMAS JEFFERSON UNIVERSITY	$128,189	Trans-NIH Recovery Act Research Support Signaling through the RAF-MEK-ERK1/2 MAP kinase pathway is critical for a wide variety of biological processes in both normal and disease states. Our long term goal is to determine mechanisms underlying regulation of this pathway and identify the downstre See details	National Institutes of Health	9/25/2009
THE INSTITUTE FOR CANCER RESEARCH	$125,322	Trans-NIH Recovery Act Research Support Research into the mechanisms that specify chromosome segregation has revealed a plethora of new anti-cancer drug targets. In spite of these new discoveries, the mechanism by which inhibitors of mitosis kill tumor cells remains poorly understood. From a cl See details	National Institutes of Health	1/28/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$125,118	Trans-NIH Recovery Act Research Support A central issue in the study of mortality and health at the older ages is the long term effect of early childhood health. This is especially important given that there have been very rapid declines in mortality at the oldest ages which can not be adequate See details	National Institutes of Health	6/08/2009
WISTAR INSTITUTE OF ANATOMY & BIOLOGY (INC)	$125,022	Trans-NIH Recovery Act Research Support Wound and tissue injuries are common medical problems that often lead to excessive scar formation and subsequent loss of organ function without normal tissue replacement. Understanding the molecules that control scarless regenerative healing can provide a See details	National Institutes of Health	9/14/2009
Porter's Day Care & Education Center	$124,848	ARRA - Early Head Start Through Early Head Start ARRA Expansion the department provides funding to sub-recipients for 128 more slots through Center-based and Home-based service delivery options to pregnant women, infants and toddlers from low-income families by targeting high qu This spending item is part of a $2,540,725 allocation. See details	Administration for Children and Families	11/18/2009
PUBLIC HEALTH MANAGEMENT CORPORATION	$124,288	ARRA - Immunization The prevention and control of vaccine preventable diseases is a major priority for the Philadelphia Department of Public Health (PDPH). Invasive meningococcal disease, pertussis, and invasive Haemophilus influenzae serotype b infections (Hib) are three c This spending item is part of a $125,288 allocation. See details	Centers for Disease Control and Prevention	9/03/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$123,666	Trans-NIH Recovery Act Research Support The proposed studies examine mechanisms by which aging impairs wakefulness. First, we propose using a recently described novel technique that utilizes a tagged unfolded protein sensor to quantitatively measure misfolded proteins (Wen and Glenn, Molecular See details	National Institutes of Health	9/04/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$122,938	Trans-NIH Recovery Act Research Support The CRIC study participants are a diverse group of people with kidney disease, half of whom have diabetes. This ancillary study of pulse wave velocity was undertaken to determine to what degree this non traditionalrisk factor influences the risks of targe See details	National Institutes of Health	9/30/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$122,525	Trans-NIH Recovery Act Research Support It is the primary objective of this program to elucidate correlates of immune-mediated protection against HIV-1 infection using pre-clinical animal models. To this end, Project 1 will determine humoral and cell-mediated immune responses to an attenuated S This spending item is part of a $5,581,859 allocation. See details	National Institutes of Health	9/01/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$121,598	Trans-NIH Recovery Act Research Support The Epilepsy Phenome/Genome Project is investigating how genes influence the phenotypes of common and rare epilepsies and has proposed to accelerate collection of phenotypic information by hiring a research assistant at each clinical center. This spending item is part of a $1,558,189 allocation. See details	National Institutes of Health	9/25/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$121,352	Trans-NIH Recovery Act Research Support Our studies supported by the parent R01 grant have identified a novel ion channel complex that controls neuronal excitability and may be involved in pathophysiological conditions such as apnea, paralysis, seizure and epilepsy. The requested funding will See details	National Institutes of Health	8/20/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$121,236	Trans-NIH Recovery Act Research Support This project examines the neural basis of spatial navigation, distinguishing between visual and nonvisual (amodal) spatial codes. This knowledge is critical for development of rehabilitation strategies in the blind. In particular, further characterizat See details	National Institutes of Health	7/22/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$120,840	Trans-NIH Recovery Act Research Support Patient recruitment and retention Patient recruitment and retention of study subjects has been excellent in this study. The COMET Network was able to screen 108 potential subjects. From these there were 12 screen fails, 3 subjects withdrew consent, two This spending item is part of a $7,915,507 allocation. See details	National Institutes of Health	9/28/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$120,078	Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area (15) Translational Science and specific Challenge Topic (15-MH-105) Strategies to Support Uptake of Interventions within Clinical Community and Settings. Implementation of evidence-based treatments into ment This spending item is part of a $918,498 allocation. See details	National Institutes of Health	9/24/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$119,796	Trans-NIH Recovery Act Research Support The O Brien Urology Research Program addresses the cellular molecular mechanisms that cause stress and obstruction induced lower urinary tract symptoms (LUTS). . The three new P and F projects that are included in the Administrative Supplement. Th This spending item is part of a $421,456 allocation. See details	National Institutes of Health	9/29/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$119,179	Trans-NIH Recovery Act Research Support This Administrative Supplement to Look AHEAD will increase the scientific impact of Look AHEAD and retain and/or create new staff positions at each of 15 local sites and the Coordinating Center. These requests parallel the submission of requests from the See details	National Institutes of Health	9/28/2009
THOMAS JEFFERSON UNIVERSITY	$118,959	Trans-NIH Recovery Act Research Support This supplement will be used exclusively to pusue the generation and characterization of new lines of mice expressing a mutant form of the inhibitory Fc receptor FcgammaRIIB from a transgene. Maintenance of this research will allow the continued employme See details	National Institutes of Health	9/29/2010
CHILDRENS HOSPITAL OF PHILADELPHIA	$118,000	Trans-NIH Recovery Act Research Support Eosinophilic esophagitis (EE) is an emerging worldwide disease that mimics gastroesophageal reflux disease (GERD) and can lead to esophageal narrowing and stricture (1-4). EE is differentiated from GERD by the magnitude of mucosal eosinophilia and epithe This spending item is part of a $930,342 allocation. See details	National Institutes of Health	9/18/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$117,654	Trans-NIH Recovery Act Research Support In this supplement application, we propose two studies that expand two specific aims in the parent grant in directions that will form a foundation for a new R01 grant focusing on learning and treatment processes in aphasia. In each study, we will use See details	National Institutes of Health	7/17/2009
DREXEL UNIVERSITY	$117,506	ARRA - Prevention and Wellness--Communities Putting Prevention to Work This past quarter, PhiladelphiaG??s CPPW was able to make great strides in in completing its main tobacco control objectives. An executive order made 183 recreation centers, playgrounds, and outdoor pools smoke-free, affecting ovever 3.7 million visits. New... Show more This spending item is part of a $10,356,927 allocation. See details	Centers for Disease Control and Prevention	3/19/2010
SAYRE HEALTH CENTER	$115,584	ARRA Health Center Integrated Services Development Initiative[g1] Increased Demand for Services. Hire a full time clinical physician, clinical assistant, and administrative assistant. Our goal is to increase the community's accessibility to healthcare by being available to them when they need us momost.... Show more See details	Health Resources and Services Administration	3/27/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$115,250	Trans-NIH Recovery Act Research Support A residue level visualization of protein structures changing with time through associated water in transmembrane (TM) helices, proton channels, fast folding proteins, reverse transcriptase inhibitors and fibrils will be obtained by two dimensional infrare See details	National Institutes of Health	9/30/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$115,200	Trans-NIH Recovery Act Research Support This is a request for supplemental ARRA funding for an existing U19 grant for 1 year. We are currently requesting a no cost extension. With the requested funds will support the salary for new personnel to establish several new approaches in our U19 gran This spending item is part of a $175,200 allocation. See details	National Institutes of Health	7/19/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$114,516	Trans-NIH Recovery Act Research Support Stem cells, and how they are controled is a key question in biomedical research. The protein, Zfh1, controls adult stem cells in the Drosophila testis. This supplement has accelerated our ability to identify the suite of Zfh1 target genes that control sel See details	National Institutes of Health	1/01/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$112,730	Trans-NIH Recovery Act Research Support This proposal is a for a ARRA administrative supplement, that entails the non viral mediated gene delivery to the retina for retinal degenerative diseases. It focuses on two types of retinal degenerations, RPE65 Leber s Congenital amauriosis, a retinal pi See details	National Institutes of Health	9/16/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$112,711	Trans-NIH Recovery Act Research Support In the first project, we revealed that superoxide is produced not only from semiflavin site but also more from the semiquinone site, which is completely new. In addition, quinone binding site inhibitors kill semiquinone signal, but electrons dynamically m See details	National Institutes of Health	4/23/2010
TRUSTEES OF THE UNVERSITY OF PENNSYLVANIA	$111,983	Trans-NIH Recovery Act Research Support This is a proposal for an administrative supplement to my parent grant NS17910, to extend our studies of electrical excitability in vivo to an investigation of the role of an ion channel regulatory protein complex in synaptic transmission. It supports th See details	National Institutes of Health	9/25/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$111,708	Trans-NIH Recovery Act Research Support An unfortunate consequence of the treatments currently used to treat pediatric cancers is infertility. An important issue to consider is whether a child's fertility status later in life is likely to be impacted by his treatment. Ideally, this should occu This spending item is part of a $465,023 allocation. See details	National Institutes of Health	9/22/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$111,280	Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant): Experiments are proposed to investigate the interaction between two risk factors for drug abuse: prenatal stress and being female. It is hypothesized that prenatal stress alters the neural systems that respond to novel This spending item is part of a $644,216 allocation. See details	National Institutes of Health	7/16/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$110,232	Trans-NIH Recovery Act Research Support Patients with chronic kidney disease (CKD) have an increased mortality rate and cardiovascular disease (CVD) accounts for approximately 50% of deaths in these patients. It is an atypical form of atherosclerosis with increased deposition of calcium in the See details	National Institutes of Health	7/16/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$108,957	Trans-NIH Recovery Act Research Support Young children differ in how quickly and effectively they master their native language, with these differences being connected to a variety of social and environmental factors. A well known observation is that vocabulary growth is related to the socio eco See details	National Institutes of Health	8/10/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$108,950	Trans-NIH Recovery Act Research Support Our investigations of POH, a hereditary form of heterotopic (extra skeletal) ossification, are an opportunity to understand key factors regulating stem cell fate decisions, specifically those in the musculoskeletal system. Increased understanding of heter See details	National Institutes of Health	9/18/2009
FOX CHASE CANCER CENTER	$108,000	Trans-NIH Recovery Act Research Support Dr. Yu-Ning Wong, a Medical Oncologist at Fox Chase Cancer Center is dedicated to a career in cancer health services research. Her goal is to develop a multidisciplinary research program to understand the impact of insurance design on cancer drug utilizat See details	National Institutes of Health	9/15/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$108,000	Trans-NIH Recovery Act Research Support This proposal will investigate how cells of the respiratory tract sense and attack disease causing bacteria that attempt to steal iron for their growth. The goals of the supplement are to identify targets of Lcn2 dependent gene activation by 1) cultured See details	National Institutes of Health	9/08/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$107,920	Trans-NIH Recovery Act Research Support This is an administrative supplement request to a parent K25 grant AG027785. I propose to perform imaging and image processing on a large number of postmortem brain samples in order to expand the computational atlas of the human hippocampus that I created See details	National Institutes of Health	9/04/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$107,615	Trans-NIH Recovery Act Research Support The cone photoreceptors in the retina are responsible for day- and color vision. These cones are lost in many diseases of the retina which lead to severe vision deficit and even blindness. This research proposal supplement evaluates the recovery of functi See details	National Institutes of Health	1/29/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$107,444	Trans-NIH Recovery Act Research Support The goal of this ARRA application is to accelerate the pace of the current scope of the PENN Udall Center while adding retaining jobs. Briefly, the goals of this Udall Center are to elucidate mechanisms of brain degeneration in patients with Parkinson s d See details	National Institutes of Health	9/24/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$106,849	Recovery Act Comparative Effectiveness Research - AHRQ The Scalable PArtnering Network for CER: Across Lifespan, Conditions, and Settings, or SPAN, will develop a distributed research network that is interoperable across a range of health care systems and sites, incorporating large and diverse patienent populat... Show more This spending item is part of a $8,272,272 allocation. See details	Agency for Healthcare Research and Quality	9/28/2010
THOMAS JEFFERSON UNIVERSITY	$106,755	Trans-NIH Recovery Act Research Support The specific aims of the proposal are to investigate: 1] The role of the C- terminal domain in channel gating. Deletion of 60aa from the C-terminal tail or 10aa from the cytosol- exposed loop between TM domains 4 & 5 cause loss of channel function. Point See details	National Institutes of Health	3/30/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$106,619	Trans-NIH Recovery Act Research Support The goal of this supplement is to rapidly break new ground in chromosomal mechanisms and cellular function. This supplement has enabled us to purchase equipment to accelerate the rate of our research activities and has enabled us to perform the experim See details	National Institutes of Health	9/09/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$106,428	Trans-NIH Recovery Act Research Support The plan for this administrative supplement is to recruit undergraduate students from Temple University and faculty members in computer science from a local community college that are interested in enhancing their graphical programming skills. They will b See details	National Institutes of Health	8/04/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$105,606	ARRA - Head Start Head Start 2009 ARRA COLA Quality Improvement Funding The ARRA award provided a curriculum training for (20) EHS Staff (including home visiting staff, health educators, family service liaisons, center base liaison). To increase knowledge and skill set See details	Administration for Children and Families	5/28/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$104,316	Recovery Act Comparative Effectiveness Research - AHRQ EHRs have the potential to anchor a learning healthcare system where each clinical encounter is an opportunity to learn and to improve clinical outcomes. We propose to link EHRs to disease-specific registries in a distributed network of pediatricic healthca... Show more This spending item is part of a $11,743,165 allocation. See details	Agency for Healthcare Research and Quality	9/28/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$104,159	Trans-NIH Recovery Act Research Support This administrative supplement to parent grant, DK 48215, intends to accelerate the pace of the animal studies, murine outlet obstruction experiments, which are major components of Aims 2 and 3 of the parent grant. Funds are sought for the purpose of hiri See details	National Institutes of Health	9/30/2009
MATERNITY CARE COALITION	$103,916	ARRA - Head Start Award Title: Head Start 2009 ARRA COLA Quality Improvement Funding; Description: funds to be used for a Cost of Living Adjustment for EHS staff salaries , training and staff development, human resource and community needs assessments and child care heal See details	Administration for Children and Families	5/28/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$103,316	Trans-NIH Recovery Act Research Support The title of this award is Primary Immune Deficiency Treatment Consortium (PIDTC). Primary immune deficiencies (PIDs) are rare, life-threatening inherited defects in the immune system. Specific goals are to characterize the long term outcomes and late ef This spending item is part of a $2,483,108 allocation. See details	National Institutes of Health	9/11/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$103,259	Trans-NIH Recovery Act Research Support The goal of this project is to increase understanding of retinal iron homeostasis through the study of transgenic and knockout mice. These mice are expected to develop retinal degeneration with features of age related macular degeneration, serving both as See details	National Institutes of Health	9/01/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$102,770	Trans-NIH Recovery Act Research Support This supplement request outlines our plan to purchase new imaging equipment to accelerate the pace of discovery, and to broaden the approach described in the original grant proposal, which will lead to new discoveries and result in high quality publicatio See details	National Institutes of Health	9/30/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$102,619	NCI's Community Cancer Centers Program (NCCCP) - The network of community hospitals is a complex pilot program whose mission is, through research, to determine ways to bring state of the art cancer care and clinical trials to patients in their local comm This spending item is part of a $75,135,000 allocation. See details	National Institutes of Health	9/04/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$102,395	Trans-NIH Recovery Act Research Support Silent Cerebral Infarct (SCI) is the most common cause of severe neurological disease in children with sickle cell anemia, occurring in 22% of this population prior to their 18th birthday. The overall goal of this trial is to determine whether blood trans This spending item is part of a $1,571,661 allocation. See details	National Institutes of Health	9/07/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$102,208	Trans-NIH Recovery Act Research Support The emergence and reemergence of epidemic arthropod borne diseases has led to significant world wide morbidity and mortality. These vector borne viruses have not only developed highly effective strategies to hijack cellular machinery and to subvert host i See details	National Institutes of Health	7/22/2009
DREXEL UNIVERSITY	$101,700	Trans-NIH Recovery Act Research Support Cocaine addicts exhibit decreased metabolic basal activity in the orbitofrontal cortex (OFC), as well as decreased metabolic responses to natural reward associated stimuli, relative to healthy controls. However, in addicts, the OFC also shows increased me See details	National Institutes of Health	6/23/2011
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$101,470	Trans-NIH Recovery Act Research Support This proposal describes experiments that have been performed by Ms. Heidi Bretscher and are being pursued by others in my laboratory to understand the relationship between chromatin structure and BRCA1 function in DNA repair. Ms. Bretscher was hired as a See details	National Institutes of Health	9/15/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$101,270	Trans-NIH Recovery Act Research Support This proposal will further our understanding of GI development and cancer, and allow for the development of novel diagnostic and possibly therapeutic tools in the future. The current proposal has created one additional job in the biomedical research fiel See details	National Institutes of Health	1/18/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$101,270	Trans-NIH Recovery Act Research Support In this award application we outline a strategy to identify genes that regulate cancer cell invasion, an early step in cancer metastasis, using the zebrafish. We have shown that zebrafish meltdown (mlt) mutants develop a cancer-like phenotype as a result See details	National Institutes of Health	2/16/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$101,067	Trans-NIH Recovery Act Research Support This supplement request outlines plans to hire personnel to accelerate the pace of discovery and to broaden the approach outlined in the original grant proposal to accommodate new discoveries from our lab and published work. See details	National Institutes of Health	12/04/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$100,952	Trans-NIH Recovery Act Research Support Lactoccocus lactis expression of Mrs3 and Mrs4 yeast mitochondrial carrier proteins and assessment of their iron transport activities in whole cells or liposomes. In the original proposal all studies of iron transport and the roles of mitochondrial carrie See details	National Institutes of Health	9/18/2009
AMERICAN COLLEGE OF RADIOLOGY, THE	$100,001	Trans-NIH Recovery Act Research Support In support of ACRIN's initiative to enhance remote data capture (RDC) systems used to conduct clinical trials; the ADOPT funds will be utilized to develop an Implementation and Integration Plan, User Requirements Specifications, and Platform Requiremen See details	National Institutes of Health	9/17/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$100,000	Trans-NIH Recovery Act Research Support Skeletal growth is characterized by gender-, maturation-, and race- specific increases in cortical dimensions and trabecular volumetric bone mineral density (vBMD). Children with Crohn disease (CD) have numerous risk factors for impaired bone accrual, inc See details	National Institutes of Health	8/17/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$100,000	Trans-NIH Recovery Act Research Support The proposed multisite research project seeks to advance our understanding of the neural mechanisms underlying human spatial memory. Epileptic patients undergoing surgical invasive monitoring as part of the clinical treatment of drug resistant epilepsy wi See details	National Institutes of Health	7/17/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$100,000	Trans-NIH Recovery Act Research Support The purchase of a new microscope will accelerate data collection and scientific output for our studies for this research project, all aims proposed rely on high resolution light microscopy, and fluorescence microscopy for the detection of various islet a See details	National Institutes of Health	12/28/2009
THE CHILDREN'S HOSPITAL OF PHILADELPHIA	$100,000	Trans-NIH Recovery Act Research Support The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a multifunctional protein that both transports Cl- across the apical plasma membrane of epithelial cells and regulates ion transport by other proteins, such as the Epithelial Sodium Channe See details	National Institutes of Health	5/28/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$100,000	Trans-NIH Recovery Act Research Support The goal of this project is to increase recruitment and retention of underrepresented and underserved populations into AIDS Clinical Trials Group (ACTG) clinical trials. The ACTG is committed to enrollment of domestic clinical trial participants in propor This spending item is part of a $1,130,883 allocation. See details	National Institutes of Health	9/21/2009
Seamaac Inc	$100,000	ARRA - Prevention and Wellness--Communities Putting Prevention to Work This past quarter, PhiladelphiaG??s CPPW was able to make great strides in in completing its main tobacco control objectives. An executive order made 183 recreation centers, playgrounds, and outdoor pools smoke-free, affecting ovever 3.7 million visits. New... Show more This spending item is part of a $10,356,927 allocation. See details	Centers for Disease Control and Prevention	3/19/2010
THE CHILDREN'S HOSPITAL OF PHILADELPHIA	$99,999	Trans-NIH Recovery Act Research Support The proposed Mental Retardation and Developmental Disabilities Research Center (MRDDRC) was established in 1990 and renewed in 1995 and 1999. It represents the collaboration of the Children's Hospital of Philadelphia and the University of Pennsylvania (Pe See details	National Institutes of Health	9/16/2009
PHILADELPHIA DEPT OF PUBLIC HEALTH	$99,999	ARRA - Prevention and Wellness--Communities Putting Prevention to Work This past quarter, Philadelphia's CPPW enhanced evaluation team completed follow-up data collection on: 1) corner store environmental assessments in 200 stores, 2) food purchases of 4,000 corner store customers, 3) school environmnmental assessments in 100 ... Show more This spending item is part of a $1,747,143 allocation. See details	Centers for Disease Control and Prevention	9/30/2010
CHILDRENS HOSPITAL OF PHILADELPHIA	$99,998	Trans-NIH Recovery Act Research Support Inherited disorders of intrahepatic bile duct development are a major cause of morbidity and mortality in the pediatric population. In recent years, advances have been made toward understanding the genetic control of liver development, but relatively litt See details	National Institutes of Health	1/31/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$99,995	Trans-NIH Recovery Act Research Support Funding is sought to purchase an inverted epifluorescent microscope equipped with environmental chamber and video capabilities to conduct in vitro tumor microenvironment studies. See details	National Institutes of Health	8/28/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$99,991	Trans-NIH Recovery Act Research Support There are currently over 250,000 survivors of childhood cancer in the U.S. Recent diagnostic therapeutic advances in pediatric oncology have led to greater survival rates in children and young adults with malignancies. However, while cancer therapies impr See details	National Institutes of Health	9/15/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$99,982	Trans-NIH Recovery Act Research Support This supplement allows for characterization at a cellular level the events leading to the early increases in matrix stiffness that precede fibrosis; specifically to determine which cells in the liver secrete collagen and elastin immediately after injury; See details	National Institutes of Health	9/01/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$99,970	Trans-NIH Recovery Act Research Support Impaired urea synthesis and consequent hyperammonemia (HA) are common occurrences in disorders of congenital defects of the urea cycle and of fatty acid oxidation (FAO), nonalcoholic fatty liver disease (NAFLD) and/or Metabolic Syndrome (MS). Still unknow See details	National Institutes of Health	6/17/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$99,928	Trans-NIH Recovery Act Research Support Obesity and associated diseases such as type II diabetes are increasing at an alarming rate throughout the world. These proposed experiments will investigate the cellular mechanisms contributing to the development of leptin resistance, a pathological sta See details	National Institutes of Health	12/14/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$99,803	Trans-NIH Recovery Act Research Support We propose to incorporate a monodisperse titania filler in dental composites, which possesses excellent biocompatibility, radiopacity, osteoconductivity, and most importantly an elastic modulus (rutile: ~ 230 GPa) approximately three times greater than th See details	National Institutes of Health	3/08/2010
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$99,801	Trans-NIH Recovery Act Research Support The goal of this supplemental application is to examine the regulation of expression and role of Pax6 isoforms during RA-dependent differentiation of wild type P19 and P19 AS-2 cells (lack expression of PBX proteins) to neuronal cells. Specifically we wi See details	National Institutes of Health	1/12/2010
MONELL CHEMICAL SENSES CENTER	$99,744	Trans-NIH Recovery Act Research Support This is an award to purchase a LabMaster Fluid Intake Recording System in order to accelerate the tempo of research in NIH R01 project DK-46791 Physiology of calcium appetite. A crucial component of this project is the measurement of calcium consumption See details	National Institutes of Health	3/22/2010
UNIVERSITY OF THE SCIENCES IN PHILADELPHIA	$99,590	ARRA - Scholarships for Disadvantaged Students ARRA-Scholarships for Disadvantaged Students See details	Health Resources and Services Administration	9/03/2009
THE CHILDREN'S HOSPITAL OF PHILADELPHIA	$99,551	Trans-NIH Recovery Act Research Support Lysosomal storage diseases (LSDs) are a large group of inherited enzyme deficiencies that produce fatal degenerative syndromes in children, with most having severe brain disease manifest as mental retardation. Neurogenetic diseases have lesions throughout See details	National Institutes of Health	5/28/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$99,500	Trans-NIH Recovery Act Research Support Thyroid hormone receptors (TRs) are ligand-dependent, transcriptional regulators of metabolism. TRs repress gene expression in the absence of hormone, which is paradigmatic for other nuclear receptors (NRs) that function as repressors in the unliganded st See details	National Institutes of Health	1/15/2010
THE CHILDREN'S HOSPITAL OF PHILADELPHIA	$99,457	Trans-NIH Recovery Act Research Support Our work focuses on the mechanisms by which transcription factors regulate the development of diverse hematopoietic lineages, and how these factors orchestrate terminal differentiation with cell cycle arrest. These functions require key nuclear factors to See details	National Institutes of Health	5/27/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$99,140	Trans-NIH Recovery Act Research Support The supplementary funding allowed us to hire two part time research assistants to work on the data that has already collected to enhance our current parent study. The central goal of this supplement is twofold: (1)maximize our targeted subject sample and See details	National Institutes of Health	8/01/2009
THE INSTITUTE FOR CANCER RESEARCH	$99,064	Trans-NIH Recovery Act Research Support Supplemental funds are requested for U19AI083008, G?Immune Mechanisms That Control Ectromelia Virus (ECTV) InfectionG? (PI, Sigal, 5/1/2009-4/30/2014). The requested supplemental funds will be used for the purchase of equipment that will facilitate and ac See details	National Institutes of Health	7/06/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$99,000	Trans-NIH Recovery Act Research Support The principal goals for the 24-27 years update since July 2005 will now include: (A) development of an enantioselective total synthesis of the potent insecticidal agent (+)-nodulisporic acid A, (B) completion of the total synthesis of the challenging macr See details	National Institutes of Health	1/22/2010
TEMPLE UNIVERSITY	$98,327	Trans-NIH Recovery Act Research Support The research proposed in this application intends to provide new biological markers and therapeutic strategies to fight the vascular complications of obesity and insulin resistance. According to the American Heart Association, cardiovascular disease (CDV) See details	National Institutes of Health	12/30/2009
TEMPLE UNIVERSITY	$98,325	Trans-NIH Recovery Act Research Support BCR/ABL fusion tyrosine kinase transforms HSC causing chronic myelogenous leukemia in chronic phase (CML-CP). BCR/ABL modulates the response to ?spontaneous? DNA damage to promote genomic instability. The latter may lead to resistance to tyrosine kinase i See details	National Institutes of Health	9/03/2009
GYNECOLOGIC ONCOLOGY GROUP , THE	$97,770	Trans-NIH Recovery Act Research Support The Gynecologic Oncology Group (GOG) is the foremost multidisciplinary cooperative clinical trial research group devoted to the study of gynecologic malignancies. Since its inception in 1970, the GOG has been a recognized leader in the development of new This spending item is part of a $489,402 allocation. See details	National Institutes of Health	7/31/2009
THOMAS JEFFERSON UNIVERSITY	$97,625	Thomas Jefferson University has been awarded a contract to provide tumor types to the NCI for The Cancer Genome Atlas (TCGA) project. Specifically this award is to fund the provision of glioma cases. These cases are all primary and untreated. The colle See details	National Institutes of Health	6/02/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$97,269	Trans-NIH Recovery Act Research Support Chronic pelvic pain is a major symptom of many functional pelvic disorders and may develop as a result of cross sensitization in the pelvis. The TRPV1 receptor is predominantly expressed in small diameter primary afferent neurons and was shown to contrib See details	National Institutes of Health	9/17/2009
THE INSTITUTE FOR CANCER RESEARCH	$96,891	ARRA - Community Services Block Grant Kinetic studies involving rapid mixing techniques are a critical component of our NIGMS-sponsored research aimed at understanding fundamental aspects of protein folding, including the structural and dynamic properties of unfolded states and early kinetic See details	National Institutes of Health	9/21/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$96,872	Trans-NIH Recovery Act Research Support Cardiovascular disease (CVD) is the leading cause of death in the western world. However, why some individuals with identical risk factor profiles will go on to develop CVD, whereas others will not, is simply not understood. One explanation is that CVD is This spending item is part of a $837,468 allocation. See details	National Institutes of Health	8/31/2009
DREXEL UNIVERSITY	$96,787	Trans-NIH Recovery Act Research Support This project will give undergraduate college students and one summer faculty member from a non-research intensive local college an experience in a professional research lab performing discovery research, as well as exposure to entrepreneurship and commerc See details	National Institutes of Health	6/05/2009
DREXEL UNIVERSITY	$96,707	Trans-NIH Recovery Act Research Support In a parent grant entitled Quantitative Analysis of Cerebral Cortex in Aging Monkeys (R01AG021133-4) we have proposed to study alterations in microcolumns throughout the entire cerebral cortex of monkeys of both sexes and ages that cover the entire adult This spending item is part of a $205,096 allocation. See details	National Institutes of Health	9/18/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$96,336	Trans-NIH Recovery Act Research Support We are addressing the physiology of aqueous humor outflow regulation, concentratingon cell volume regulatory transporters and adenosine receptors of Schlemms canal,juxtacanalicular and trabecular meshwork cells, and on the potential role of cell volumein See details	National Institutes of Health	8/04/2009
PHILADELPHIA CORPORATION FOR AGING	$95,645	Aging Home-Delivered Nutrition Services for States ARRA funding of home delivered nutrition services will augment existing resources, replace revenue lost from local resources due to the economic downturn and support the continued delivery of meals to vulnerable older Americans. Home delivered mealsls help... Show more This spending item is part of a $1,479,863 allocation. See details	Administration on Aging	3/18/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$94,794	Trans-NIH Recovery Act Research Support The increase in the number of patients with end stage liver disease has led to rapid growth of the waitlist for transplantation and increased efforts to enlarge the donor pool with and adult-to-adult living donor (LD) liver transplantation. Fundamental di See details	National Institutes of Health	3/08/2010
THE INSTITUTE FOR CANCER RESEARCH	$94,700	Trans-NIH Recovery Act Research Support Title: Structure and Dynamic Determinants of Ion Channel Assembly by Adapter Proteins (Administrative Supplement) Abstract: The devastating disease cystic fibrosis is caused by the inability of the cell to bring the cystic fibrosis transmembrane conduct See details	National Institutes of Health	7/16/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$94,194	Trans-NIH Recovery Act Research Support As a supplmenet to the Center for Nursing Outcomes Resarch we will purchase scientific equipment to enhance our capacity to conduct research using large data sets and to accelerate the tempo of that research. We propose to purchase a a Dell server with 2 See details	National Institutes of Health	5/20/2010
THOMAS JEFFERSON UNIVERSITY	$94,029	Trans-NIH Recovery Act Research Support Meiosis is the process used to generate haploids from diploids. The completion of meiosis is coupled to differentiation programs that form gametes that are capable of sexual fusion. Our previous results have defined a protein kinase network that control See details	National Institutes of Health	12/04/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$93,654	Trans-NIH Recovery Act Research Support This project includes three extensions of the Specific Aims in the parent grant. Specific Aim 1 was to obtain normative data on a diagnostic battery of language and short-term memory (STM) abilities suitable for individuals with aphasia. There are two ext See details	National Institutes of Health	7/17/2009
DREXEL UNIVERSITY	$93,337	Trans-NIH Recovery Act Research Support This award focuses on the structural and functional characterization of antimicrobial natural products. The precise molecular details of how these agents fold and how they recognize their targets will be derived from high resolution X-ray crystal structur See details	National Institutes of Health	9/30/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$92,930	Trans-NIH Recovery Act Research Support This proposal requests funds for an SFC (Supercritical Fluid Chromatography) instrument for analysis of enantioenriched samples. It will replace an outdated HPLC and greatly increase the tempo of this NIH supported research.This prediction was entirely c See details	National Institutes of Health	12/31/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$92,636	Trans-NIH Recovery Act Research Support We are requesting an administrative supplement (NOT OD 09 056) under the Recovery Act to add a full time research coordinator to our staff. The additional research position will provide an immediate economic benefit to the region by generating another fu See details	National Institutes of Health	12/15/2009
THOMAS JEFFERSON UNIVERSITY	$91,356	Trans-NIH Recovery Act Research Support This funding is specifically to support the stipend of a postdoctoral research. The key project supported by the parent grant is the role of the dSlo channel-binding protein Slob in synaptic transmission. Slob and dSlo play an especially prominent role See details	National Institutes of Health	6/18/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$91,257	Trans-NIH Recovery Act Research Support A more thorough characterization of how costimulatory receptors and cytokines regulate the metabolic brprocesses of lipid and nucleotide biosynthesis is being undertaken in these studies. It is believed these brinsights may lead to the development of nov See details	National Institutes of Health	9/02/2009
PHILADELPHIA, CITY OF	$90,540	ARRA ?Health Information Technology and Public Health The Division of Disease Control (DDC) is the recipient of Epidemiology and Laboratory Capacity (ELC) Cooperative Agreement award for the Philadelphia Department of Public Health (PDPH), and therefore, will be the executive sponsor of this project.t. The Div... Show more This spending item is part of a $252,752 allocation. See details	Centers for Disease Control and Prevention	8/02/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$89,409	ARRA - Nurse Faculty Loan Program Financial support for educational programs to prepare advanced practice nurses for roles as faculty in academic programs. See details	Health Resources and Services Administration	6/14/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$88,315	Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area (05) Comparative Effectiveness Research and specific Challenge Topics, 05-AA-101: Innovative Analysis of Existing Clinical Datasets and 05-AA-102: Adaptive Designs and Person-Centered Data Analysis for Alcoh This spending item is part of a $939,768 allocation. See details	National Institutes of Health	9/30/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$88,108	Trans-NIH Recovery Act Research Support This award is to add one slot in each of two years of the Cancer Biostatistics training grant. The objective of this program is to trainindividuals to be rigorous and independent academic investigators able to use the range of approaches in biostatistics See details	National Institutes of Health	9/17/2009
DELAWARE VALLEY CITIZENS COUNCIL FOR CLEAN AIR	$87,703	ARRA - Prevention and Wellness--Communities Putting Prevention to Work This past quarter, PhiladelphiaG??s CPPW was able to make great strides in in completing its main tobacco control objectives. An executive order made 183 recreation centers, playgrounds, and outdoor pools smoke-free, affecting ovever 3.7 million visits. New... Show more This spending item is part of a $10,356,927 allocation. See details	Centers for Disease Control and Prevention	3/19/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$87,526	Trans-NIH Recovery Act Research Support Administrative supplement for purposes of accelerating the tempo of research in several key areas as well as enhancing job creation and retention for investigators and support staff. This spending item is part of a $230,798 allocation. See details	National Institutes of Health	9/30/2009
THOMAS JEFFERSON UNIVERSITY	$86,316	Trans-NIH Recovery Act Research Support Liver injury due to prescription and non-prescription medication use is an important public health problem. Drug-induced liver injury (DILI) is the most common reason for adverse actions taken on drugs by the Food and Drug Administration. Detection of DIL This spending item is part of a $231,680 allocation. See details	National Institutes of Health	3/29/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$86,109	Trans-NIH Recovery Act Research Support Administrative supplements are requested for the purchase of necessary equipment items to expand the capability of our IR stopped flow apparatus. This new setup will extend our ability to measure time resolved IR spectra of biological reactions, including See details	National Institutes of Health	9/30/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$85,976	Trans-NIH Recovery Act Research Support Despite the development of several targeted agents, patients with advanced cancer that fail conventional therapies have an extremely poor prognosis. Identification of the mechanisms that contribute to therapeutic resistance is essential to improve clinica This spending item is part of a $654,821 allocation. See details	National Institutes of Health	7/16/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$85,500	Trans-NIH Recovery Act Research Support This supplement prevented job loss, thereby stimulated the American economy, and accelerated our anesthetic mechanisms research, a fundamental biological problem for 25,000,000 Americans undergoing anesthesia annually See details	National Institutes of Health	9/08/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$83,915	Trans-NIH Recovery Act Research Support The intent of the Wistar/Penn SPORE in Skin Cancer is to decrease the morbidity and mortality of skin cancers through improved understanding of the pathogenesis of these diseases using novel, validated molecular biomarkers of risk, progression and prognos This spending item is part of a $175,825 allocation. See details	National Institutes of Health	9/01/2009
THOMAS JEFFERSON UNIVERSITY	$83,753	Trans-NIH Recovery Act Research Support This application is to seek a Recovery Act Administrative Supplement to the parent project, 1R01GM081601-1A2 G?Functions of tRNA modificationsG?, which investigates the mechanism of tRNA(m1G37) modification by the bacterial TrmD and the eukaryotic/archaea See details	National Institutes of Health	8/13/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$82,308	Trans-NIH Recovery Act Research Support The purpose of this Administrative Supplement is to explore a new therapeutic target for globoid cell leukodystrophy (GLD) that was discovered during our NIH-funded research and accelerate the translation of these approaches into the clinic. Consistent w This spending item is part of a $106,568 allocation. See details	National Institutes of Health	7/08/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$81,636	Trans-NIH Recovery Act Research Support The goal of this project is to develop a way to observe whether or not new therapies are effective in correcting the disease process in muscles of boys with Duchenne muscular dystrophy (DMD) without the need to take muscle biopsies. We will extend our pas This spending item is part of a $839,690 allocation. See details	National Institutes of Health	9/29/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$81,141	Trans-NIH Recovery Act Research Support Positional cloning of rare multisystem genetic disorders that follow Mendelian inheritance patterns allows for the identification of genes and molecular pathways that play critical roles in human development. While the impact of disease gene identificati This spending item is part of a $240,901 allocation. See details	National Institutes of Health	9/16/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$80,951	Trans-NIH Recovery Act Research Support This application addresses the broad Challenge Area (15) Translational Sciences and specifically the challenge topic 15-DK-106 : Translating basic hematology concepts. Diamond Blackfan anemia is a rare bone marrow failure syndrome characterized by red ce See details	National Institutes of Health	2/22/2011
COMMUNITY COLLEGE OF PHILADELPHIA	$80,293	ARRA - Scholarships for Disadvantaged Students United State Department of Health and Human Services awarded Community College of Philadelphia $80,293.00 for budget period from July 1, 2010 through June 30, 2011. HRSA SDS funding provided through American Recovery and Reinvestment Act of 2009 (ARRA) a as... Show more See details	Health Resources and Services Administration	6/14/2010
THE INSTITUTE FOR CANCER RESEARCH	$80,034	Trans-NIH Recovery Act Research Support Title: KINETOCHORE STRUCTURE AND FUNCTION The long term goals of my research program at the Fox Chase Cancer Center are to understand the key mechanical and regulatory events that specify accurate chromosome segregation in human cells. We have focused ou See details	National Institutes of Health	1/04/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$79,959	Trans-NIH Recovery Act Research Support Money from the ARRA supplement helped pay for the costs of mouse experiments on the gene MYH9, which causes kidney disease in rare families, and was associated in 2008-9 with common forms of kidney disease in African-Americans. The supplement money hel See details	National Institutes of Health	5/28/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$79,750	Trans-NIH Recovery Act Research Support Cells start migration by generating protrusions, which require the dynamic assembly of a branched actin network and remodeling of the plasma membrane. How actin dynamics and membrane activities are coordinated during cell migration is a fundamental questi See details	National Institutes of Health	1/14/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$77,977	Trans-NIH Recovery Act Research Support The colonic epithelium is subjected to a variety of challenges that result in a wide range of diseases and disorders, including colitis, polyp formation and malignant transformation. We have identified the Let 7a3 and Let 7b microRNAs, which are critical See details	National Institutes of Health	9/16/2009
DREXEL UNIVERSITY	$77,708	Trans-NIH Recovery Act Research Support Developing neurons undergo complex changes in gene expression that translate into mechanistic differences in how the neuron functions. The majority of studies aimed at understanding the mechanisms of axon extension, as they relate to regenerative attempts See details	National Institutes of Health	9/20/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$77,687	Trans-NIH Recovery Act Research Support We are requesting an Administrative Supplement to our existing NEI-sponsored R01, Mechanisms of Learning a Visual Discrimination, which examines neural mechanisms of learning. The proposal meets the criteria of the ARRA, in that it will accelerate high-im See details	National Institutes of Health	1/29/2010
DREXEL UNIVERSITY	$77,040	Trans-NIH Recovery Act Research Support Concussions, sometimes referred to as mild traumatic brain injuries, are a significant public health issue in this country. Prevalence estimates vary widely, ranging from 300,000 sports related concussions annually (a CDC earlier estimate) to over 2 mill See details	National Institutes of Health	9/13/2010
DREXEL UNIVERSITY	$76,959	Trans-NIH Recovery Act Research Support Amyotrophic lateral sclerosis (ALS) is characterized by the progressive and selective loss of motor neurons (MNs) in the motor cortex, brainstem, and spinal cord, resulting in death of patients 2-5 years after diagnosis. Glutamate-mediated excitotoxicity See details	National Institutes of Health	9/06/2010
DREXEL UNIVERSITY	$76,959	Trans-NIH Recovery Act Research Support Amyotrophic lateral sclerosis (ALS) is characterized by the progressive and selective loss of motor neurons (MNs) in the motor cortex, brainstem, and spinal cord, resulting in death of patients 2-5 years after diagnosis. Glutamate-mediated excitotoxicity See details	National Institutes of Health	9/06/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$75,696	Trans-NIH Recovery Act Research Support The ultimate goal of this project is to identify genes influencing obesity related traits. This proposal requests support for genotyping SNPs in the overall sample in order to identify those newly discovered variants that segregate with obesity phenotype See details	National Institutes of Health	6/18/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$75,085	Trans-NIH Recovery Act Research Support The intent of the Wistar/Penn SPORE in Skin Cancer is to decrease the morbidity and mortality of skin cancers through improved understanding of the pathogenesis of these diseases using novel, validated molecular biomarkers of risk, progression and prognos This spending item is part of a $175,825 allocation. See details	National Institutes of Health	9/01/2009
FOOD TRUST, THE	$75,000	ARRA - Prevention and Wellness--Communities Putting Prevention to Work Suburban Cook County (Cook County Department of Public Health/Public Health Institute of Metropolitan Chicago), Illinois was awarded $15.9 Million. Communities Putting Prevention to Work , an obesity prevention project addressingng nutrition and physical a... Show more This spending item is part of a $15,898,821 allocation. See details	Centers for Disease Control and Prevention	3/18/2010
CENTER IN THE PARK INC	$74,089	ARRA - Communities Putting Prevention to Work: Chronic Disease Self-Manage In collaboration with the Recovery Act - Communities Putting Prevention to Work (CPPW) program, this funding will support the deployment of evidence-based chronic disease self-management programs that empower older people withth chronic disease to maintain ... Show more This spending item is part of a $100,000 allocation. See details	Administration on Aging	3/31/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$73,963	Trans-NIH Recovery Act Research Support The diversity supplement to R01NR05352 has two primary goals: 1) To provide an opportunity for a post master s student interested in health related research to spend two years engaged in a mentored experience in scientific inquiry and to develop research See details	National Institutes of Health	7/17/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$73,811	Trans-NIH Recovery Act Research Support This proposal is for a Rare Cancer Genetics Registry (RCGR). The proposal is being submitted for Challenge Area: 07: Enhancing Clinical Trials and specific Challenge Topic: Rare Disease Genetic Patient Registry: 07-OD(ORDR)-102. We will develop a registry This spending item is part of a $987,770 allocation. See details	National Institutes of Health	9/29/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$72,867	Trans-NIH Recovery Act Research Support In this administrative supplement to the parent grant, 1 R21 DK078368 01A2 (Magnesium and the Metabolic Syndrome Trial [MMST]), we propose to: 1. Expedite goals of the parent grant by increasing percent effort of the Principal Investigator (PI) and Co In See details	National Institutes of Health	12/21/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$71,900	Trans-NIH Recovery Act Research Support The primary objective of this research is to clarify the extent to which daytime sleepiness influences the ability of adults with heart failure (HF) to take care of themselves. We believe that poor sleep impairs self care through its effects on cognition. See details	National Institutes of Health	8/10/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$71,870	Trans-NIH Recovery Act Research Support The biochemical and structural work proposed here will provide the bases to understanding the nucleation mechanism of Lmod, a novel actin filament nucleator discovered with support from R01 GM073791. Thespecific isoform of Lmod studied here (cardiac Lmod2 See details	National Institutes of Health	9/09/2009
THOMAS JEFFERSON UNIVERSITY HOSPITALS, INC.	$71,404	ARRA Grants for Training in Primary Care Medicine and Dentistry Training and Enhancement This project is the creation, implementation, and evaluation of the Jefferson Interprofessional Primary Care Dual Degree program (IPCDDP). The IPCDDP addresses the critical need to redesign the nation's primary y care system to meet the mandates of the Ins... Show more This spending item is part of a $1,225,039 allocation. See details	Health Resources and Services Administration	8/31/2010
CHILDRENS HOSPITAL OF PHILADELPHIA	$70,600	Trans-NIH Recovery Act Research Support Chronic kidney disease (CKD) and its metabolic derangements substantially affect the well-being of children. In order to define the nature, magnitude, and temporal evolution of the adverse effects of progressive CKD, we propose to extend the follow-up of See details	National Institutes of Health	6/23/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$70,508	Trans-NIH Recovery Act Research Support The goal of this project is to identify objective, quantitative bio-molecular parameters that correlate with healing outcomes for diabetic foot ulcers (DFUs). Chronic non-healing DFUs are a widespread and serious clinical problem with high rates of morbid This spending item is part of a $902,641 allocation. See details	National Institutes of Health	9/21/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$69,429	Trans-NIH Recovery Act Research Support Air pollution, particularly O3, induces exacerbations of asthma that substantially worsen morbidity and mortality. In healthy individuals inhalation of O3 elicits mechanisms such as homeostatic increase in SP D synthesis that protect the lung from develop This spending item is part of a $1,000,000 allocation. See details	National Institutes of Health	9/28/2009
WISTAR INSTITUTE OF ANATOMY & BIOLOGY	$68,638	Trans-NIH Recovery Act Research Support For three decades, alterations of protein-coding oncogenes and tumor suppressors genes have been considered as the causes of tumorigenesis. Recent advances proved without doubts that cancer is a complex genetic disease involving structural and expression This spending item is part of a $650,865 allocation. See details	National Institutes of Health	7/17/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$67,533	Trans-NIH Recovery Act Research Support OVERALL PURPOSE: TODAY is a collaborative group funded by the National Instituate of Diabetes and Digestive and Kidney Diseases (NIDDK) to conduct +B20t a clinical trial of therapies in children with type 2 diabetes (T2D). The TODAY study has enrolled 70 This spending item is part of a $1,102,576 allocation. See details	National Institutes of Health	4/12/2010
DREXEL UNIVERSITY	$67,449	Trans-NIH Recovery Act Research Support Drug overdose is the single greatest cause of mortality among injection drug users (IDUs) in the U.S. Fatal heroin overdoses cause more than half of all deaths among IDUs, which far exceeds the proportion of deaths due to AIDS or other causes. Administrat This spending item is part of a $439,400 allocation. See details	National Institutes of Health	6/01/2009
PHILADELPHIA PARENT CHILD CENTER	$67,276	ARRA - Head Start The awarded funds will provide an increase in salaries and benefit for teachers, social workers and family counselors. In adition, improve the program particulary in Health and safety items. Several pieces of kitchen equipment were repaired in the past See details	Administration for Children and Families	6/18/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$67,087	Trans-NIH Recovery Act Research Support The intended impact of the research is to establish a platform for preclinical testing of peptides and small molecules that promote the formation of new beta cells from ducts. Such an approach could, if ultimately successful, significantly lower the barri See details	National Institutes of Health	12/09/2009
SALUS UNIVERSITY	$66,402	Trans-NIH Recovery Act Research Support To conduct preliminary comparisons of measurements of macular thickness, optic disc parameters, intraocular pressure (IOP) and central corneal thickness (CCT) between non-myopic young adults and COSMICC subjects. The study is designed to test 2 hypothese See details	National Institutes of Health	8/11/2009
CENTER IN THE PARK INC	$64,116	Trans-NIH Recovery Act Research Support We are conducting an economic evaluation of a depression intervention Beat the Blues (BTB). Beat the Blues is being tested in a randomized trial funded by NIMH (R01 MH079814). The intervention involves up to 10 sessions (combination of home and telephone This spending item is part of a $455,083 allocation. See details	National Institutes of Health	6/20/2011
CHILDRENS HOSPITAL OF PHILADELPHIA	$64,059	Trans-NIH Recovery Act Research Support Planning Grant for Genome-Wide Association by Study of Craniofacial Microsomia -- CFM involves the asymmetric underdevelopment of facial skeletal bones and soft tissue and occurs in over 1 in 3500 births. Typically affecting the jaw and ear, CFM impairs This spending item is part of a $954,646 allocation. See details	National Institutes of Health	9/22/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$64,027	Trans-NIH Recovery Act Research Support Klf4 (Kruppel like factor 4, previously known as GKLF) is an epithelial zinc finger protein which controls cellular proliferation and differentiation in the skin and gastrointestinal tract. Klf4 mRNA is found at high evels in growth arrested cells and is See details	National Institutes of Health	1/18/2010
DELAWARE VALLEY REGIONAL PLANNING COMMISSION	$64,000	ARRA - Prevention and Wellness--Communities Putting Prevention to Work PhiladelphiaG??s nutrition and physical activity challenges are daunting: nearly half of children are overweight or obese, low-income communities have little access to healthy foods, and opportunities for physical activity in schohools, neighborhoods, and w... Show more This spending item is part of a $15,018,277 allocation. See details	Centers for Disease Control and Prevention	3/19/2010
THE INSTITUTE FOR CANCER RESEARCH	$63,794	Trans-NIH Recovery Act Research Support Supplemental funds are requested for the recently awarded U19AI083008, G?Immune Mechanisms That Control Ectromelia Virus (ECTV) InfectionG? (PI, Sigal, 5/1/2009-4/30/2014). The requested supplemental funds will be used for the purchase of equipment to be This spending item is part of a $98,316 allocation. See details	National Institutes of Health	8/13/2009
COMMUNITY COLLEGE OF PHILADELPHIA	$63,378	ARRA - Scholarships for Disadvantaged Students United State Department of Health and Human Services awarded Community College of Philadelphia $63,378.00 for budget period from September 1, 2009 through June 30, 2010. The additional funding is provided through American Recovery and Reinvestment Act ofof ... Show more See details	Health Resources and Services Administration	9/01/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$62,394	Trans-NIH Recovery Act Research Support In this supplement, we will test the predictive role of two amplification events and gene fusion status in alveolar rhabdomyosarcoma by testing samples from a single clinical trial. This study will involve applying our assays for amplification and gene fu This spending item is part of a $129,973 allocation. See details	National Institutes of Health	9/01/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$62,000	Trans-NIH Recovery Act Research Support The overall goal of this research is to understand the sperm function regulation by calcium, cyclic nucleotides and ion channels at the molecular level. This proposal focuses on the roles of a sperm tail ion channel (CatSper1) we discovered. CatSper1 from See details	National Institutes of Health	7/19/2010
CHILDRENS HOSPITAL OF PHILADELPHIA	$61,611	Trans-NIH Recovery Act Research Support Between 2001-2003 there were 11.6 million annual ambulatory care visits for skin and soft tissue infections, with a 31% increase in emergency department visits compared to the previous decade, according to the National Hospital AmbulatoryMedical Care Surv See details	National Institutes of Health	7/17/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$61,523	Trans-NIH Recovery Act Research Support The overall aim of the Obesity and Surgical Outcomes (OBSOS) study is to improve the outcomes of obese patients who must undergo general, orthopedic, vascular or urological surgery. Obesity has been implicated in predisposing patients to worse surgical ou See details	National Institutes of Health	1/07/2010
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$60,350	ARRA - Prevention and Wellness--Communities Putting Prevention to Work This past quarter, PhiladelphiaG??s CPPW was able to make great strides in in completing its main tobacco control objectives. An executive order made 183 recreation centers, playgrounds, and outdoor pools smoke-free, affecting ovever 3.7 million visits. New... Show more This spending item is part of a $10,356,927 allocation. See details	Centers for Disease Control and Prevention	3/19/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$57,775	ARRA - Prevention and Wellness--Communities Putting Prevention to Work This past quarter, PhiladelphiaG??s CPPW was able to make great strides in in completing its main tobacco control objectives. An executive order made 183 recreation centers, playgrounds, and outdoor pools smoke-free, affecting ovever 3.7 million visits. New... Show more This spending item is part of a $10,356,927 allocation. See details	Centers for Disease Control and Prevention	3/19/2010
GSI HEALTH, LLC	$57,500	BAH will provide support in reaching four primary objectives associated with this Task Order. These objectives are: 1) to conduct an environmental scan to assess the feasibility and validity of the measure concepts and existing measures identified and pro This spending item is part of a $5,783,026 allocation. See details	Program Support Center	9/29/2011
HEALTH FEDERATION OF PHILADELPHIA THE	$57,325	ARRA - Head Start COLA and Quality Improvement Funding for Early Head Start Program serving 69 infants and toddlers and 7 pregnant women. Program offers home based option for childern who reside North Philadelphia inner city vicinity within these zip codes ? 19121, 19122 See details	Administration for Children and Families	5/29/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$55,828	Trans-NIH Recovery Act Research Support The clinical profiles of several developmental disorders, including autism spectrum disorders (ASD), involve varying degrees of comorbid language impairment (LI). Clinical diagnosis of LI, however, does not itself identify the associated underlying neuron See details	National Institutes of Health	5/10/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$55,275	Trans-NIH Recovery Act Research Support Title: Characterization of Type-2 Cytokine-Producing NK Cells Abstract: Allergic immune responses are biased toward the production of type-2 cytokines. We have identified new surface markers of a small subset of human natural killer (NK) cells that prod This spending item is part of a $503,770 allocation. See details	National Institutes of Health	6/04/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$54,601	ARRA - Maternal and Child Health (MCH) Pediatric Research Network Program Overall Purpose: Minor blunt head trauma in children is common. Although important traumatic brain injuries are infrequent, clinicians obtain cranial computed tomography (CT) in up to 50% of children with minor blunt head trauauma, exposing them to radiati... Show more This spending item is part of a $3,498,012 allocation. See details	Health Resources and Services Administration	7/28/2010
DREXEL UNIVERSITY	$54,019	Trans-NIH Recovery Act Research Support This Competitive Revision for 5R00DE018188-03 proposes to expand the parent project to include a non-viral method of gene delivery based upon ultrasound destruction of DNA-associated microbubbles. This ultrasound-assisted gene transfer (UAGT) works diffe This spending item is part of a $434,047 allocation. See details	National Institutes of Health	9/23/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$54,002	Trans-NIH Recovery Act Research Support The broad, long-term objectives of this work are to establish a practical and empirically-sound means to assess children's acute stress reactions after potentially traumatic events (eg, accidents, fires, disasters) and to expand our understanding of acute See details	National Institutes of Health	5/29/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$54,000	Trans-NIH Recovery Act Research Support The proposed supplement will accelerate research on how single neurons in the frontal cortex and the caudate nucleus reflect visual perceptual decision-making with different reward schedules. This research will identify neural correlates of perceptual dec See details	National Institutes of Health	9/23/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$54,000	Trans-NIH Recovery Act Research Support This Administrative Supplement will support hiring of additional personnel to allow expansion of the ongoing clinical trial to up to 5 additional sites. The clinical trial tests the hypothesis that adding or increasing the mesalamine dose can reduce fecal See details	National Institutes of Health	8/04/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$54,000	Trans-NIH Recovery Act Research Support Determining the role of motor protein Myo1c in kidney biologySpecific Aims:This award was a supplement (as described below) to my previous K award that was aimed at investigating the hypothesis that Neph1 and the associated foot process junctional protein See details	National Institutes of Health	2/18/2010
HEALTH FEDERATION OF PHILADELPHIA, THE	$53,924	Trans-NIH Recovery Act Research Support This application addresses Broad Challenge Area (09): Health Disparities and the Specific Challenge Topic, 09 MD 103: Initiating Innovative Interventions to Prevent Family Violence. We are engaged in the large scale demonstration project evaluating the This spending item is part of a $999,990 allocation. See details	National Institutes of Health	9/24/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$53,830	Trans-NIH Recovery Act Research Support The liver develops from cells of the ventral foregut endoderm which differentiate into heptoblasts and proliferate into the adjacent mesenchyme to form the liver bud. Most of these cells mature into hepatocytes, but some of those surrounding the portal v See details	National Institutes of Health	8/04/2009
Lighthouse Inc	$53,782	ARRA - Head Start This award provides for ARRA Cost of Living Adjustment (COLA) and Quality Improvement Funding consistent with the provisions of Section 640(a)(5) of the Head Start Act for the Head Start program. Head Start promotes the school readiness of low-income chil This spending item is part of a $3,033,980 allocation. See details	Administration for Children and Families	6/17/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$53,536	Trans-NIH Recovery Act Research Support The purpose of this study is to compare 5 to 12 year old siblings who are discordant in their weight status (i.e., normal weight or overweight obese) on select eating traits both under laboratory and free living conditions. We are requesting an Administr See details	National Institutes of Health	8/04/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$53,158	Trans-NIH Recovery Act Research Support The obesity epidemic has been linked to increasing incidence of diabetes, cardiovascular disease and other complications. Diet and exercise are essential to weight management; however, it is obvious that many patients would require drug treatment to achie See details	National Institutes of Health	1/14/2010
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$52,748	Trans-NIH Recovery Act Research Support Research to be conducted under the ARRA mechanism will accelerate the scientific tempo of a trial designed to understand the efficacy, mechanisms, and cost-effectiveness of alternative resuscitation strategies for septic shock. Trial recruitment will be e This spending item is part of a $2,314,994 allocation. See details	National Institutes of Health	9/30/2009
PHILADELPHIA, CITY OF	$52,141	ARRA - Immunization Two main Immunization areas will be the focus of the Philadelphia Department of Public HealthG??s (PDPH) project - the Vaccines for Adults At Risk Program (VFAAR) and the KIDS Registry. Utilizing funds awarded through the ARRA Supplemental Funding for Rea This spending item is part of a $564,358 allocation. See details	Centers for Disease Control and Prevention	9/15/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$51,955	Trans-NIH Recovery Act Research Support Gastric dysmotility is relevant in several clinical disorders including gastroparesis and functional dyspepsia. This grant reflects the PI?s long-term research objectives to advance the evaluation and treatment of gastric motility disorders through a bet See details	National Institutes of Health	8/04/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$51,916	Trans-NIH Recovery Act Research Support Autosomal dominant polycystic kidney disease (ADPKD), affecting 500,000 Americans, is the most common potentially lethal genetic disease and is characterized by cyst overgrowth that destroys the kidney. Protein synthesis and delivery are essential to the See details	National Institutes of Health	9/18/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$51,912	Trans-NIH Recovery Act Research Support Detection and Care for Depression in the Perinatal Period Major depressive disorder (MDD) among women in pregnancy and the postpartum can have profoundly negative implications for women; fetal, infant, and child development; and the larger family. This mi See details	National Institutes of Health	6/05/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$51,725	Trans-NIH Recovery Act Research Support This project will open communication channels and facilitate collaboration among IRB staff and members in Botswana and their counterparts at U.S. institutions that have large research activities ongoing in Botswana. A week long meeting and tour of sites i See details	National Institutes of Health	9/25/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$51,433	Trans-NIH Recovery Act Research Support This proposal for an Administrative Supplement for our P50 for the O Brien Urology Research Program entitled Bladder Wall remodeling in LUTS (2P50 DK052620 11). This Research Program addresses the cellular molecular mechanisms that cause stress and ob See details	National Institutes of Health	8/03/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$50,460	Trans-NIH Recovery Act Research Support This is a supplemental application to DK067558 entitled Acinus: A Novel Corepressor of RAR-Regulated Gene Expression under the program for administrative supplements utilizing recovery act funds for summer research experiences for students and science ed See details	National Institutes of Health	7/16/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$50,080	Trans-NIH Recovery Act Research Support Recruitment of posto-doctoral fellow supported by the ARRA supplement has helped increase the tempo of the research. This has also enabled us to investigate the precise mitochondrial targets of alcohol induced toxicity in human cells. If successful, the t See details	National Institutes of Health	9/03/2010
TRUSTEES OF THE UNVERSITY OF PENNSYLVANIA	$50,054	Trans-NIH Recovery Act Research Support All viruses tightly regulate cellular processes to create an environment supportive for replication. An understanding of the mechanisms viruses use to do this is vital for our knowledge of viral pathogenesis as well as the normal cellular controls of thes See details	National Institutes of Health	7/22/2009
THOMAS JEFFERSON UNIVERSITY	$50,002	Trans-NIH Recovery Act Research Support The Kimmel Cancer Center at Jefferson has been selected as an Early Adopter Center of NCIG??s Clinical Trials Reporting Program (CTRP). As such, KCC is required to use the new system beginning with trials initiated in September 2009, and report to NCI on See details	National Institutes of Health	9/23/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$50,000	Trans-NIH Recovery Act Research Support This is an administrative supplement application for a mentored clinical scientist development award (K08) to conduct genetic and functional studies of the vesicular monoamine transporter 1 (VMAT1 SLC18A1) gene on chromosome 8p21 implicated in susceptibil See details	National Institutes of Health	7/16/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$50,000	Trans-NIH Recovery Act Research Support Use of an administrative supplement to support 2 additional research nurses to enroll study subjects in ongoing work exploring neighborhood level characteristics influencing patterns of pneumococcal carriage in children. See details	National Institutes of Health	9/11/2009
HEALTH FEDERATION OF PHILADELPHIA, THE	$50,000	ARRA Health Center Integrated Services Development Initiative[g1] The Health Federation of Philadelphia (HFP) is proposing to develop and implement an Integrated Disease Management Registry and Master Patient Index based on the integration of Electronic Health Records through a Health Information Excxchange. The four par... Show more See details	Health Resources and Services Administration	9/14/2009
THOMAS JEFFERSON UNIVERSITY	$50,000	Trans-NIH Recovery Act Research Support This Administrative Supplement provides funds for the purchase of scientific equipment (Cascade II Illuminating Camera), which will allow the implementation of cutting edge microscopy and fluorescent protein technology in the study of alcohol effect on mi See details	National Institutes of Health	8/03/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$50,000	Trans-NIH Recovery Act Research Support Use of an administrative supplement to support 2 additional research nurses to enroll study subjects in ongoing work exploring neighborhood level characteristics influencing patterns of pneumococcal carriage in children See details	National Institutes of Health	9/07/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$50,000	Trans-NIH Recovery Act Research Support The proposal is an administrative supplement to the K01 grant Mathematical Techniques for Control of Epidemic Trypanosoma cruzi Transmission. It requests funding for a geographic investigator to accelerate the progress of the parent award. See details	National Institutes of Health	8/02/2010
FOX CHASE CANCER CENTER	$49,999	Trans-NIH Recovery Act Research Support For the 100 years of its history, Fox Chase Cancer Center (FCCC) has been guided by a singular mission to reduce the burden of human cancer. Its 1904 hospital charter called for 'the study of the cause, treatment and prevention of cancer and for the disse See details	National Institutes of Health	9/23/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$49,991	Trans-NIH Recovery Act Research Support The proposal requests the support of a geographic and mathematical postdoctoral researcher to support and advance the research described in the parent K01 project Mathematical Techniques for Control of Epidemic Trypanosoma cruzi Transmission (1K01AI079162 See details	National Institutes of Health	9/11/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$49,968	Trans-NIH Recovery Act Research Support This proposal is to obtain funding for hiring a new Research Technician for one year. We identified and hired a Research Technician who is helping out the PI to perform experiments outlined in the parental K08 grant and in the attached research proposal. See details	National Institutes of Health	8/16/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$49,900	Trans-NIH Recovery Act Research Support The goal of this project is to understand the mechanisms by which extracellular stimuli can regulate protein expression in a cell through the process of signal induced alternative splicing. This supplement will accelerate progress toward increasing our u See details	National Institutes of Health	1/15/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$49,833	Trans-NIH Recovery Act Research Support Efficient dendritic cell (DC) maturation is necessary for the successful development of immune responses. We have demonstrated that SeV strain Cantell (C) has an outstanding ability to trigger DC maturation through a mechanism distinct from that triggered See details	National Institutes of Health	9/15/2010
CHILDRENS HOSPITAL OF PHILADELPHIA	$49,607	Trans-NIH Recovery Act Research Support This application describes a comprehensive training program designed to transition Dr. Ryan from a mentored scientist into an independent investigator in the area of Pediatric Gl and Hepatology studying the role of the Notch signaling pathway in liver and See details	National Institutes of Health	8/28/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$49,348	Trans-NIH Recovery Act Research Support The childhood obesity epidemic raises important clinical and public health questions about the effects of both obesity and obesity treatment on bone development. Osteoporotic fractures are a major cause of morbidity and mortality in the aged. However, pea See details	National Institutes of Health	9/30/2009
THOMAS JEFFERSON UNIVERSITY	$49,272	Trans-NIH Recovery Act Research Support Under the auspices of the parent grant, we have demonstrated that both morpholino antisense and a small drug molecule can inhibit ALDH2, both in vitro and in vivo, and as a consequence acetaldehyde leevls are increased. Thus, these agents may assist us i See details	National Institutes of Health	8/20/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$48,844	Trans-NIH Recovery Act Research Support This project will focus on research efforts related to mechanisms underlying migration and invasion by iesophageal epithelial cells; related to epithelial mesenchymal transition of esophageal epithelial cells; and related to the role of microRNAs and co See details	National Institutes of Health	6/09/2009
Youth Enrichment Programs Inc	$48,816	ARRA Child Care and Development Block Grant The American Recovery and Reinvestment Act (ARRA) Child Care and Development Fund (CCDF) funds have two mandatory earmarks, Infant/Toddler and Quality. The Infant/Toddler funds are utilized for new center-based Keystone Babies programs. Specifically, th This spending item is part of a $60,146,767 allocation. See details	Administration for Children and Families	4/09/2009
FUND FOR PHILADELPHIA, INC.	$48,603	ARRA - Prevention and Wellness--Communities Putting Prevention to Work This past quarter, PhiladelphiaG??s CPPW was able to make great strides in in completing its main tobacco control objectives. An executive order made 183 recreation centers, playgrounds, and outdoor pools smoke-free, affecting ovever 3.7 million visits. New... Show more This spending item is part of a $10,356,927 allocation. See details	Centers for Disease Control and Prevention	3/19/2010
THE CHILDREN'S HOSPITAL OF PHILADELPHIA	$48,600	Trans-NIH Recovery Act Research Support This award provides additional funding to study the molecular basis of novel genetic forms of congenital hyperinsulinism (HI) in children. Previous years focused on the mechanisms of the hyperinsulinism / hyperammonemia syndrome associated with dominant, See details	National Institutes of Health	12/28/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$48,419	Trans-NIH Recovery Act Research Support The PI is investigating the role of Notch1 and Trib-2 proteins in macrophage fusion and granuloma formation. Three novel Notch-modified transgenic animals were generated by the Principal Investigator, and a Trib2 knock-out animal was recently generated in See details	National Institutes of Health	9/11/2009
RECONSTRUCTIVE ORTHOPAEDIC ASSOCIATES II, P.C.	$48,360	Trans-NIH Recovery Act Research Support Infection associated with allograft transplantation and prosthesis use can occur in any patient, and is particularly prevalent and challenging in immunocompromised individuals. When developed, infection can lead to prolonged disability with immense psycho This spending item is part of a $875,280 allocation. See details	National Institutes of Health	9/17/2009
Kinder Academy Inc	$48,289	ARRA Child Care and Development Block Grant The American Recovery and Reinvestment Act (ARRA) Child Care and Development Fund (CCDF) funds have two mandatory earmarks, Infant/Toddler and Quality. The Infant/Toddler funds are utilized for new center-based Keystone Babies programs. Specifically, th This spending item is part of a $60,146,767 allocation. See details	Administration for Children and Families	4/09/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$47,298	Trans-NIH Recovery Act Research Support For the past 22 years, our Mitochondria! Inborn Errors of Metabolism research project has been testing the hypothesis that: Genetic variants in the mitochondrial genome play an important role in the etiology of human disease. This research has resulted in See details	National Institutes of Health	9/16/2010
AMERICAN CITIES FOUNDATION	$47,250	Trans-NIH Recovery Act Research Support OAI, Inc. and its HWWT consortium will provide critical health and safety training for 1,335 newly hired and/or retrained weatherization, construction, environmental remediation and debris removal workers and contractors in Illinois, Louisiana, Maine and This spending item is part of a $482,000 allocation. See details	National Institutes of Health	9/06/2009
SPECIAL PEOPLE IN NORTHEAST, INC.	$46,790	ARRA - Head Start This award provides for ARRA Cost of Living Adjustment (COLA) and Quality Improvement Funding consistent with the provisions of Section 640(a)(5) of the Head Start Act for the Head Start program. Head Start promotes the school readiness of low-income chil This spending item is part of a $3,033,980 allocation. See details	Administration for Children and Families	6/17/2009
LASALLE UNIVERSITY	$46,209	ARRA - Nurse Faculty Loan Program Nurse Faculty Loan Program-ARRA. Funds are to be used to provide loans to students enrolled in Master of Science in Nursing Program's Nursing Education track. The goal of the project is to enhance the number of MSN students preparing to teach nursing afte See details	Health Resources and Services Administration	8/10/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$45,999	Trans-NIH Recovery Act Research Support This supplemental award supports the Accelerating Clinical Trials of Novel Oncologic Path Ways (ACTNOW) program for Protocol ANBL0931, which is a Phase III Study of Chimeric Antibody 14.18 in High-Risk Neuroblastoma. The primary objective of study ANBL09 This spending item is part of a $1,981,588 allocation. See details	National Institutes of Health	8/07/2009
WISTAR INSTITUTE OF ANATOMY & BIOLOGY (INC)	$45,669	Trans-NIH Recovery Act Research Support The goal of this predoctoral training program is to provide students with the intellectualand technical skills required to solve important and complex biological problems that can be most effectively addressed by studies at the chemistry-biology interface See details	National Institutes of Health	8/03/2009
COALITION OF CANCER COOPERATIVE GROUPS	$45,581	Trans-NIH Recovery Act Research Support This award is for the Eastern Cooperative Oncology Group's (ECOG) participation in the Re-engineering Protocol Implementation and Development of Phase 1 to 3 Protocols (RaPID) project, focused on improving processes for activating National Cancer Institut This spending item is part of a $439,325 allocation. See details	National Institutes of Health	9/17/2010
FOOD TRUST, THE	$45,000	ICF Macro was awarded a contract to develop a Training and Technical Assistance Resource Center to support CPPW grantees and provide on-going access to information on expert policy, system and environmental change, field technical assistance, training too This spending item is part of a $13,958,455 allocation. See details	Centers for Disease Control and Prevention	4/26/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$44,863	Trans-NIH Recovery Act Research Support The overall goal of this application is to discover and validate multiple novel plasma protein biomarkers of human ovarian cancer. We will initially discover a substantial number of candidate biomarkers through parallel analysis of two complementary model This spending item is part of a $993,896 allocation. See details	National Institutes of Health	6/29/2009
UNIVERSITY OF THE SCIENCES IN PHILADELPHIA	$44,846	Trans-NIH Recovery Act Research Support In biological systems, transmembrane peptides embedded in lipid membranes are essential for cellular function such as ion conductance, energy conversion, and signaling. The goal of the parent grant is to gain a better understanding of the structural and d See details	National Institutes of Health	7/10/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$44,662	Trans-NIH Recovery Act Research Support It is the primary objective of this program to elucidate correlates of immune-mediated protection against HIV-1 infection using pre-clinical animal models. To this end, Project 1 will determine humoral and cell-mediated immune responses to an attenuated S This spending item is part of a $5,581,859 allocation. See details	National Institutes of Health	9/01/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$44,000	Trans-NIH Recovery Act Research Support This is a request for an administrative supplement to the parent grant DK067558 entitled Acinus: A Novel Corepressor of RAR-Regulated Gene Expression under the program for administrative supplements utilizing recovery act funds. We are requesting funds See details	National Institutes of Health	11/20/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$43,954	Trans-NIH Recovery Act Research Support Developing a Community-Based ASD Research Registry This application addresses Broad Challenge Area 05 (Comparative Effectiveness Research) & Specific Challenge Topic 05-MH-104 (Building ASD Registries for Use in Comparative Effectiveness Research). Enroll This spending item is part of a $500,000 allocation. See details	National Institutes of Health	9/28/2009
Providence Center	$43,750	ARRA Strengthening Communities Fund This award is made to organizations with experience in capacity building and requires that they act as a lead organization for the project in a geographic service area which is at or below poverty level. Under this award, lead grantees select nonprofit o This spending item is part of a $1,000,000 allocation. See details	Administration for Children and Families	9/21/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$43,500	Trans-NIH Recovery Act Research Support Many patients who survive the first few days of critical illness do so with multiple residual organ failures. These patients become dependent on mechanical ventilation and other organ support systems initiated in the ICU. In order to help clarify prognosi This spending item is part of a $459,156 allocation. See details	National Institutes of Health	8/31/2009
COMMUNITY DEVELOPMENT INSTITUTE HEAD START	$43,453	ARRA - Head Start This award provides ARRA funds for Head Start Quality Improvement and Cost of Living Adjustments (COLA) in accordance with FY 2009 Funding guidance ACF-PI-HS-09-06. Head Start promotes the school readiness of low-income children through the provision of See details	Administration for Children and Families	7/02/2009
DREXEL UNIVERSITY	$43,342	ARRA - Scholarships for Disadvantaged Students The intent of this grant is to award disadvantaged students scholarships that would permit them to stay in school and get into Drexel University College of Medicine. This will increase the number of disadvantaged students joining the medical profession.n. ... Show more See details	Health Resources and Services Administration	6/14/2010
NORRIS SQUARE NEIGHBORHOOD PROJECT, INC.	$42,500	ARRA Strengthening Communities Fund This award is made to organizations with experience in capacity building and requires that they act as a lead organization for the project in a geographic service area which is at or below poverty level. Under this award, lead grantees select nonprofit o This spending item is part of a $1,000,000 allocation. See details	Administration for Children and Families	9/21/2009
THOMAS JEFFERSON UNIVERSITY	$42,377	ARRA - Scholarships for Disadvantaged Students This award is a grant awarded to school based on application to Health and Human Resources. Based on the school's eligibilty and the purpose of the fund, these monies will be used to help further the education of disadvantaged medical and nursing studenent... Show more See details	Health Resources and Services Administration	6/14/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$42,180	Trans-NIH Recovery Act Research Support Leishmaniasis is a serious disease associated with a wide range of clinical manifestations caused by intracellular protozoan parasites belonging to the Genus Leishmania. While the host immune response is important in the outcome of infection, different Le See details	National Institutes of Health	9/11/2009
PUBLIC HEALTH MANAGEMENT CORPORATION	$42,000	ARRA - Prevention and Wellness--Communities Putting Prevention to Work PhiladelphiaG??s nutrition and physical activity challenges are daunting: nearly half of children are overweight or obese, low-income communities have little access to healthy foods, and opportunities for physical activity in schohools, neighborhoods, and w... Show more This spending item is part of a $15,018,277 allocation. See details	Centers for Disease Control and Prevention	3/19/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$41,738	Trans-NIH Recovery Act Research Support This supplement request is to continue our ongoing work on the cyt bc1, by pursuing during the next two years the following specific aims, which are the natural extensions of the current work. We propose: 1 To assess the critical role of the Y302 positi See details	National Institutes of Health	9/25/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$41,731	Trans-NIH Recovery Act Research Support A key component of the parent grant that this supplement supports is the measurement of phospholipase and triglyceride lipase activities in plasma from a variety of mouse models and human subjects. Using a systematic approach, we will use these assays to See details	National Institutes of Health	6/01/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$41,462	Trans-NIH Recovery Act Research Support This application addresses broad Challenge Area (05) Comparative Effectiveness Research and Specific Challenge Topic 05 MD105, Health Literacy. After examining feasibility, this intervention compares the use of a patient advocate to promote effective heal This spending item is part of a $1,013,230 allocation. See details	National Institutes of Health	9/18/2009
THOMAS JEFFERSON UNIVERSITY	$40,823	Trans-NIH Recovery Act Research Support The objectives of this supplement proposal are to understand the molecular mechanisms of prostate tumorigenesis due to deregulation of the PI3K and PTEN pathway, and to elucidate the connection of PI3K and PTEN downstream signaling components to tumor for See details	National Institutes of Health	9/08/2011
Black Women In Sport Foundation	$40,250	ARRA Strengthening Communities Fund This award is made to organizations with experience in capacity building and requires that they act as a lead organization for the project in a geographic service area which is at or below poverty level. Under this award, lead grantees select nonprofit o This spending item is part of a $1,000,000 allocation. See details	Administration for Children and Families	9/21/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$39,852	Trans-NIH Recovery Act Research Support This application is being submitted in response to ARRA funding call NOD OD 09 060 Administrative supplements providing summer research experiences for students and science educators. This proposal will fund two undergraduate students and one medical stud See details	National Institutes of Health	7/14/2009
BLUE'S BABE FOUNDATION	$39,500	ARRA Strengthening Communities Fund This award is made to organizations with experience in capacity building and requires that they act as a lead organization for the project in a geographic service area which is at or below poverty level. Under this award, lead grantees select nonprofit o This spending item is part of a $1,000,000 allocation. See details	Administration for Children and Families	9/21/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$39,457	Trans-NIH Recovery Act Research Support Two undergraduate students will be recruited to perform experiments consistent with the specific aims of the parent R01 grant. One student will study the developmental time course of KCNQ and sodium channel arrival at the axon initial segment. One stude See details	National Institutes of Health	7/21/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$39,375	Trans-NIH Recovery Act Research Support Title: Characterization of Type-2 Cytokine-Producing NK Cells Abstract: Allergic immune responses are biased toward the production of type-2 cytokines. We have identified new surface markers of a small subset of human natural killer (NK) cells that prod This spending item is part of a $503,770 allocation. See details	National Institutes of Health	6/04/2009
Childspace Co-Op Developm	$39,000	ARRA Strengthening Communities Fund This award is made to organizations with experience in capacity building and requires that they act as a lead organization for the project in a geographic service area which is at or below poverty level. Under this award, lead grantees select nonprofit o This spending item is part of a $1,000,000 allocation. See details	Administration for Children and Families	9/21/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$39,000	Trans-NIH Recovery Act Research Support This application responds to broad Challenge Area (05): Comparative Effectiveness Research (CER), and specific Challenge Topic 05-AR-101: Comparative Effectiveness of Biologics in Autoimmune Rheumatic and Skin Diseases, with emphasis on five diseases: rhe This spending item is part of a $999,370 allocation. See details	National Institutes of Health	9/28/2009
BRANCH ASSOCIATES INC.	$38,992	ARRA - Prevention and Wellness--Communities Putting Prevention to Work This past quarter, PhiladelphiaG??s CPPW was able to make great strides in in completing its main tobacco control objectives. An executive order made 183 recreation centers, playgrounds, and outdoor pools smoke-free, affecting ovever 3.7 million visits. New... Show more This spending item is part of a $10,356,927 allocation. See details	Centers for Disease Control and Prevention	3/19/2010
COMMUNITY DEVELOPMENT INSTITUTE HEAD START	$38,694	ARRA - Head Start This award provides ARRA funds for Head Start Quality Improvement and Cost of Living Adjustments (COLA) in accordance with FY 2009 Funding guidance ACF-PI-HS-09-06. Head Start promotes the school readiness of low-income children through the provision of See details	Administration for Children and Families	7/07/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$38,100	Trans-NIH Recovery Act Research Support Colorectal cancer (CRC) is one of the most commonly diagnosed cancers and the third leading cause of cancer death among Chinese Americans. Older Chinese Americans have the lowest CRC screening rate in the U.S. Physician recommendation is the strongest pre This spending item is part of a $291,096 allocation. See details	National Institutes of Health	8/31/2009
Women of Faith and Hope	$38,000	ARRA Strengthening Communities Fund This award is made to organizations with experience in capacity building and requires that they act as a lead organization for the project in a geographic service area which is at or below poverty level. Under this award, lead grantees select nonprofit o This spending item is part of a $1,000,000 allocation. See details	Administration for Children and Families	9/21/2009
GSI HEALTH, LLC	$37,900	BAH will provide technical assistance to the Beacon Community Cooperative Agreement awardees and ONC as together they lead the development of a regional healthcare strategy for Health Information Technology (HIT) ?enabled cost and quality performance impr This spending item is part of a $11,933,252 allocation. See details	Program Support Center	9/30/2010
DREXEL UNIVERSITY	$37,840	ARRA - Prevention and Wellness--Communities Putting Prevention to Work This past quarter, Philadelphia's CPPW enhanced evaluation team completed follow-up data collection on: 1) corner store environmental assessments in 200 stores, 2) food purchases of 4,000 corner store customers, 3) school environmnmental assessments in 100 ... Show more This spending item is part of a $1,747,143 allocation. See details	Centers for Disease Control and Prevention	9/30/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$37,000	Trans-NIH Recovery Act Research Support We requested funds to increase the tempo of our research progress. Funds were provided to (a) update an stopped flow fluorometer that used a computer platform that was no longer supported, and (b) increase the rate at which we can produce recombinant pro See details	National Institutes of Health	1/04/2010
CHILDRENS HOSPITAL OF PHILADELPHIA	$36,242	Trans-NIH Recovery Act Research Support To date, one must conclude that the pace of progress in disease control and preservation of functional integrity and quality of life for pediatric brain tumors remains below that of most other major types of childhood cancers. Recent advances in cellular This spending item is part of a $482,421 allocation. See details	National Institutes of Health	8/18/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$36,242	Trans-NIH Recovery Act Research Support To date, one must conclude that the pace of progress in disease control and preservation of functional integrity and quality of life for pediatric brain tumors remains below that of most other major types of childhood cancers. Recent advances in cellular This spending item is part of a $381,202 allocation. See details	National Institutes of Health	8/20/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$36,242	Trans-NIH Recovery Act Research Support To date, one must conclude that the pace of progress in disease control and preservation of functional integrity and quality of life for pediatric brain tumors remains below that of most other major types of childhood cancers. Recent advances in cellular This spending item is part of a $482,434 allocation. See details	National Institutes of Health	8/19/2009
Parkside Association of Philadelphia Inc	$36,000	ARRA Strengthening Communities Fund This award is made to organizations with experience in capacity building and requires that they act as a lead organization for the project in a geographic service area which is at or below poverty level. Under this award, lead grantees select nonprofit o This spending item is part of a $1,000,000 allocation. See details	Administration for Children and Families	9/21/2009
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$35,658	Trans-NIH Recovery Act Research Support The supplemental request under NOT-OD-09-056 supports the science of the parent project AA12640 Alcoholism: epidemiologic high risk family study and the aims of the Recovery Act through its dual objectives. The first is to retain project staff to enable This spending item is part of a $202,231 allocation. See details	National Institutes of Health	8/17/2009
ASOCIACION DE PUERTORRIQUENOS EN MARCHA, INC.	$35,602	ARRA - Head Start This award provides for ARRA Cost of Living Adjustment (COLA) and Quality Improvement Funding consistent with the provisions of Section 640(a)(5) of the Head Start Act for the Head Start program. Head Start promotes the school readiness of low-income chil This spending item is part of a $3,033,980 allocation. See details	Administration for Children and Families	6/17/2009
SPECIAL PEOPLE IN NORTHEAST, INC	$35,104	ARRA - Head Start Head Start 2009 ARRA COLA Quality Improvement Funding See details	Administration for Children and Families	6/23/2009
THOMAS JEFFERSON UNIVERSITY	$34,522	Trans-NIH Recovery Act Research Support Supplemental funds are requested for the recently awarded U19AI083008, G?Immune Mechanisms That Control Ectromelia Virus (ECTV) InfectionG? (PI, Sigal, 5/1/2009-4/30/2014). The requested supplemental funds will be used for the purchase of equipment to be This spending item is part of a $98,316 allocation. See details	National Institutes of Health	8/13/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$34,020	Trans-NIH Recovery Act Research Support This Summer Undergrad Research project will have students participate in subject recruitment, data collection, database management and analysis and resporting and dissemination activities relating to the MSST trial. Students will be fully integrated into See details	National Institutes of Health	6/22/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$33,962	Trans-NIH Recovery Act Research Support The purpose of this proposal is to provide undergraduate students with an interest in public health, genetics, and bioethics, an opportunity to work on a diverse research team that is tackling a challenging problem in public health genetics. Using sound See details	National Institutes of Health	5/31/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$33,482	Trans-NIH Recovery Act Research Support To establish the normal hepatic blood flow and portal compliance in the human liver. Hypothesize that the healthy human liver has a normal distributed range of portal pressure and blood flow per gram of hepatic tissue with limited variability. See details	National Institutes of Health	9/30/2010
DELAWARE VALLEY REGIONAL PLANNING COMMISSION	$33,433	ARRA - Prevention and Wellness--Communities Putting Prevention to Work PhiladelphiaG??s nutrition and physical activity challenges are daunting: nearly half of children are overweight or obese, low-income communities have little access to healthy foods, and opportunities for physical activity in schohools, neighborhoods, and w... Show more This spending item is part of a $15,018,277 allocation. See details	Centers for Disease Control and Prevention	3/19/2010
Community Education Alliance of West Philadelphia	$32,589	ARRA - Head Start This award provides for ARRA Cost of Living Adjustment (COLA) and Quality Improvement Funding consistent with the provisions of Section 640(a)(5) of the Head Start Act for the Head Start program. Head Start promotes the school readiness of low-income chil This spending item is part of a $3,033,980 allocation. See details	Administration for Children and Families	6/17/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$32,129	Trans-NIH Recovery Act Research Support This study continues a program of research that identifies effective safe sex media messages for African American adolescents at high risk for sexually transmitted infections (including HIV). Our research indicates that such messages can be effective whi See details	National Institutes of Health	9/28/2009
North Philadelphia Human Svcs Dev Corp	$32,000	ARRA Strengthening Communities Fund This award is made to organizations with experience in capacity building and requires that they act as a lead organization for the project in a geographic service area which is at or below poverty level. Under this award, lead grantees select nonprofit o This spending item is part of a $1,000,000 allocation. See details	Administration for Children and Families	9/21/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$32,000	Trans-NIH Recovery Act Research Support Specific Aims: Acute Lung Injury (ALI) is a common complication of sepsis and trauma and is associated with mortality of over 20%. Candidate gene studies suggest a role for common genetic variation in determining host susceptibility to ALI in critically This spending item is part of a $4,676,664 allocation. See details	National Institutes of Health	9/25/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$31,872	Trans-NIH Recovery Act Research Support This is a proposal for supplementary funding to support student summer research positions. This proposal is directed towards characterizing the proliferation and cell-cell adhesion effects of Cdx2 and will test the following hypothesis: Cdx2 inhibits co See details	National Institutes of Health	7/15/2009
WHYY, INC.	$31,428	ARRA - Prevention and Wellness--Communities Putting Prevention to Work This past quarter, PhiladelphiaG??s CPPW was able to make great strides in in completing its main tobacco control objectives. An executive order made 183 recreation centers, playgrounds, and outdoor pools smoke-free, affecting ovever 3.7 million visits. New... Show more This spending item is part of a $10,356,927 allocation. See details	Centers for Disease Control and Prevention	3/19/2010
THE CHILDREN'S HOSPITAL OF PHILADELPHIA	$31,255	Trans-NIH Recovery Act Research Support Mental retardation is a prominent clinical feature of the lysosomal storage disorders (LSD's), due to the severe pathology in the central nervous system (CNS). The LSD's constitute a significant number of the human genetic diseases that affect the CNS. Th See details	National Institutes of Health	7/20/2009
Children's Village Inc	$31,194	ARRA - Head Start This award provides for ARRA Cost of Living Adjustment (COLA) and Quality Improvement Funding consistent with the provisions of Section 640(a)(5) of the Head Start Act for the Head Start program. Head Start promotes the school readiness of low-income chil This spending item is part of a $3,033,980 allocation. See details	Administration for Children and Families	6/17/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$30,509	Trans-NIH Recovery Act Research Support Our goal is to dissect the intercellular signaling mechanisms involved in the initial specification of mammary gland tissue, and those that regulate proliferation, branching morphogenesis and cell polarity at successive stages of mammary development. Brea See details	National Institutes of Health	9/25/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$30,000	Trans-NIH Recovery Act Research Support This is a request under the American Recovery and Reinvestment Act (ARRA) of 2009 for an Administrative Supplement for the R24 grant NICHD R24 HD044964 to the Population Studies Center of the University of Pennsylvania. The current award was last reviewe See details	National Institutes of Health	9/29/2009
MONELL CHEMICAL SENSES CENTER	$30,000	Trans-NIH Recovery Act Research Support In mice, many genomic regions contain variation that results in differences in adiposity (Reed 2003; 2006; 2007; 2008). The goal of this research program is to find the gene or genes on mouse chromosome 9 that account for the quantitative trait locus Adip See details	National Institutes of Health	11/16/2009
Fairmount Community Development Corporat	$30,000	ARRA Strengthening Communities Fund ARRA Strengthening Communities Fund Nonprofits Capacity Building Program The goal of this program is to build the capacity of our nonprofit partners in order to address the broad economic recovery issues present our community, including helping low-inco This spending item is part of a $1,000,000 allocation. See details	Administration for Children and Families	9/14/2009
BUSINESS CENTER FOR ENTREPRENUERSHIP AND SOCIAL ENTERPRISE	$30,000	ARRA Strengthening Communities Fund ARRA Strengthening Communities Fund Nonprofits Capacity Building Program The goal of this program is to build the capacity of our nonprofit partners in order to address the broad economic recovery issues present our community, including helping low-inco This spending item is part of a $1,000,000 allocation. See details	Administration for Children and Families	9/14/2009
URBAN AFFAIRS COALITION	$30,000	ARRA Strengthening Communities Fund ARRA Strengthening Communities Fund Nonprofits Capacity Building Program The goal of this program is to build the capacity of our nonprofit partners in order to address the broad economic recovery issues present our community, including helping low-inco This spending item is part of a $1,000,000 allocation. See details	Administration for Children and Families	9/14/2009
BUILDABRIDGE INTERNATIONAL	$30,000	ARRA Strengthening Communities Fund ARRA Strengthening Communities Fund Nonprofits Capacity Building Program The goal of this program is to build the capacity of our nonprofit partners in order to address the broad economic recovery issues present our community, including helping low-inco This spending item is part of a $1,000,000 allocation. See details	Administration for Children and Families	9/14/2009
NATIONALITIES SERVICE CENTER OF PHILADELPHIA PA	$30,000	ARRA Strengthening Communities Fund ARRA Strengthening Communities Fund Nonprofits Capacity Building Program The goal of this program is to build the capacity of our nonprofit partners in order to address the broad economic recovery issues present our community, including helping low-inco This spending item is part of a $1,000,000 allocation. See details	Administration for Children and Families	9/14/2009
NATIONAL COMPREHENSIVE CENTER FOR FATHERS	$30,000	ARRA Strengthening Communities Fund ARRA Strengthening Communities Fund Nonprofits Capacity Building Program The goal of this program is to build the capacity of our nonprofit partners in order to address the broad economic recovery issues present our community, including helping low-inco This spending item is part of a $1,000,000 allocation. See details	Administration for Children and Families	9/14/2009
NONPROFIT TECHNOLOGY RESOURCES	$30,000	ARRA Strengthening Communities Fund ARRA Strengthening Communities Fund Nonprofits Capacity Building Program The goal of this program is to build the capacity of our nonprofit partners in order to address the broad economic recovery issues present our community, including helping low-inco This spending item is part of a $1,000,000 allocation. See details	Administration for Children and Families	9/14/2009
WOMEN'S OPPORTUNITIES RESOURCE CENTER	$30,000	ARRA Strengthening Communities Fund ARRA Strengthening Communities Fund Nonprofits Capacity Building Program The goal of this program is to build the capacity of our nonprofit partners in order to address the broad economic recovery issues present our community, including helping low-inco This spending item is part of a $1,000,000 allocation. See details	Administration for Children and Families	9/14/2009
Whosoever Gospel Mission	$30,000	ARRA Strengthening Communities Fund ARRA Strengthening Communities Fund Nonprofits Capacity Building Program The goal of this program is to build the capacity of our nonprofit partners in order to address the broad economic recovery issues present our community, including helping low-inco This spending item is part of a $1,000,000 allocation. See details	Administration for Children and Families	9/14/2009
WELCOMING CENTER FOR NEW PENNSYLVANIANS, THE	$30,000	ARRA Strengthening Communities Fund ARRA Strengthening Communities Fund Nonprofits Capacity Building Program The goal of this program is to build the capacity of our nonprofit partners in order to address the broad economic recovery issues present our community, including helping low-inco This spending item is part of a $1,000,000 allocation. See details	Administration for Children and Families	9/14/2009
YORKTOWN COMMUNITY DEVELOPMENT CORPORATION	$30,000	ARRA Strengthening Communities Fund This award is made to organizations with experience in capacity building and requires that they act as a lead organization for the project in a geographic service area which is at or below poverty level. Under this award, lead grantees select nonprofit o This spending item is part of a $1,000,000 allocation. See details	Administration for Children and Families	9/21/2009
Kensington South Neighbor Advisory Council	$30,000	ARRA Strengthening Communities Fund This award is made to organizations with experience in capacity building and requires that they act as a lead organization for the project in a geographic service area which is at or below poverty level. Under this award, lead grantees select nonprofit o This spending item is part of a $1,000,000 allocation. See details	Administration for Children and Families	9/21/2009
THOMAS JEFFERSON UNIVERSITY	$28,721	ARRA - Scholarships for Disadvantaged Students This award is to fund Scholarships Disadvantaged Allopathic Medical and Nursing Students as per the 2009 Poverty guidelines See details	Health Resources and Services Administration	9/03/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$28,350	Trans-NIH Recovery Act Research Support This award provides summer research experiences for undergraduate students on project involving DNA virus as vectors for cardiovascular diseases. The program has three important components: 1) an intense, hands on research experience working closely with See details	National Institutes of Health	6/10/2009
ALBERT EINSTEIN HEALTHCARE NETWORK	$28,300	Trans-NIH Recovery Act Research Support equipment grant See details	National Institutes of Health	7/17/2009
MONELL CHEMICAL SENSES CENTER	$28,167	Trans-NIH Recovery Act Research Support This Administrative Supplement was provided under the parent grant, Mapping Adiposity Genes in Mice. The goal of the parent grant is to find the identity of Adip5, a quantitative trait locus on chromosome 9 that determines the weight of a specific adipos See details	National Institutes of Health	4/12/2010
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	$27,003	Trans-NIH Recovery Act Research Support Shape Up! Preschoolers' Geometric Sense Predicts Future Mathematics Achievement The purpose of this longitudinal research is to develop an assessment of 36- to 38-month-old children's knowledge of fundamental geometric spatial and shape concepts in order This spending item is part of a $887,766 allocation. See details	National Institutes of Health	9/28/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$27,000	Trans-NIH Recovery Act Research Support The title of this award is Primary Immune Deficiency Treatment Consortium (PIDTC). Primary immune deficiencies (PIDs) are rare, life-threatening inherited defects in the immune system. Specific goals are to characterize the long term outcomes and late ef This spending item is part of a $2,483,108 allocation. See details	National Institutes of Health	9/11/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$26,411	Trans-NIH Recovery Act Research Support The summer research program in our laboratory will be offered to an inner city elementary science teacher. They will conduct these experiments using established methodology in our laboratory. They will analyze data and present their findings at weekly lab See details	National Institutes of Health	7/21/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$25,956	Trans-NIH Recovery Act Research Support We believe that this direct experience with health services research, combined with the didactic and mentoring aspects built into the SUMR program, will encourage interested students to pursue health related research careers. It may also feed the pipeline See details	National Institutes of Health	5/29/2009
UNIVERSITY OF THE SCIENCES IN PHILADELPHIA	$25,732	Trans-NIH Recovery Act Research Support Radiological exposure from a terror event has been identified by the CDC and the Office of Homeland Security as a potential threat worthy of significant national preparedness. Little research has been done, however, to develop risk communication strategie This spending item is part of a $163,578 allocation. See details	National Institutes of Health	7/15/2009
DREXEL UNIVERSITY	$25,678	Trans-NIH Recovery Act Research Support The primary goal of this COBRE proposal was to increase the number of active, NIH-funded biomedical researchers in the State of Delaware. This was accomplished through the efforts of a multidisciplinary group of investigators at the Nemours Research Insti This spending item is part of a $958,810 allocation. See details	National Institutes of Health	9/23/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$25,371	Trans-NIH Recovery Act Research Support This supplement award supports the Accelerating Clinical Trials of Novel Oncologic Path Ways (ACTNOW) program for Protocol ADVL0813, which is a Phase I Study of IMC-A12 (Anti-Insulin-Like Growth Factor-I Receptor Monoclonal Antibody) in Combination with C This spending item is part of a $750,000 allocation. See details	National Institutes of Health	8/13/2009
THOMAS JEFFERSON UNIVERSITY	$25,000	Trans-NIH Recovery Act Research Support The dorsal root ganglion ??DRG?? is composed of a heterogeneous population of sensory neurons that occupy distinct niches within the somatosensory nervous system. This heterogeneity represents a significant challenge to investigators interested in studyin See details	National Institutes of Health	9/30/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$25,000	Trans-NIH Recovery Act Research Support Concerns about bioterrorism with variola virus and continued outbreaks of monekypox virus in Africa have resulted in the need for safer poxvirus vaccines. A detailed understanding of poxvirus complement control proteins may lead to safer live vaccinia ba See details	National Institutes of Health	8/14/2009
UNIVERSITY OF THE SCIENCES IN PHILADELPHIA	$25,000	Trans-NIH Recovery Act Research Support The National Institutes of Health hereby awards a grant in the amount of $25000 to USP in support of Dr. Li's research. The award is pursuant to the authority of 42 USC 241 42 CFR 52 and is subject to the requirements of this statute and regulation and of See details	National Institutes of Health	1/29/2010
FRANCISVILLE NEIGHBORHOOD DEVELOPMENT CORPORATION	$25,000	ARRA Strengthening Communities Fund ARRA Strengthening Communities Fund Nonprofits Capacity Building Program The goal of this program is to build the capacity of our nonprofit partners in order to address the broad economic recovery issues present our community, including helping low-inco This spending item is part of a $1,000,000 allocation. See details	Administration for Children and Families	9/14/2009
PHILADELPHIA AREA PROJECT ON OCCUPATIONAL SAFETY & HEALTH	$25,000	ARRA Strengthening Communities Fund ARRA Strengthening Communities Fund Nonprofits Capacity Building Program The goal of this program is to build the capacity of our nonprofit partners in order to address the broad economic recovery issues present our community, including helping low-inco This spending item is part of a $1,000,000 allocation. See details	Administration for Children and Families	9/14/2009
HEALTH PROMOTION COUNCIL OF SOUTHEASTERN PENNSYLVANIA, INC.	$24,239	Recovery Act Comparative Effectiveness Research - AHRQ Dissemination is an important, but neglected component of the research process. Currently, efforts focus on disseminating interventions that have been developed and evaluated through randomized trials; however, mechanisms are also needed to disseseminate th... Show more This spending item is part of a $1,414,898 allocation. See details	Agency for Healthcare Research and Quality	8/26/2010
CHILDRENS HOSPITAL OF PHILADELPHIA	$23,990	Trans-NIH Recovery Act Research Support Proper immune responses are necessary to control pathogenic infections. It is equally important to limit immunological responses properly so that they do not cause chronic inflammation or autoimmune diseases. Thus, understanding molecular and cellular p This spending item is part of a $2,708,532 allocation. See details	National Institutes of Health	7/22/2009
LIFT, INC.	$23,000	ARRA Strengthening Communities Fund ARRA Strengthening Communities Fund Nonprofits Capacity Building Program The goal of this program is to build the capacity of our nonprofit partners in order to address the broad economic recovery issues present our community, including helping low-inco This spending item is part of a $1,000,000 allocation. See details	Administration for Children and Families	9/14/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$22,834	Trans-NIH Recovery Act Research Support Skin color plays a distinct role in the detection of and perhaps the protection from skin injury in sexual assault. We have found significant differences in ano-genital injury prevalence in Black and White females after consensual sexual intercourse and s This spending item is part of a $42,634 allocation. See details	National Institutes of Health	5/13/2010
CHILDRENS HOSPITAL OF PHILADELPHIA	$22,465	Trans-NIH Recovery Act Research Support This supplement award supports Accelerating Clinical Trials of Novel Oncologic Path Ways (ACT NOW) program for Protocol ADVL0911, which is a Phase I Dose Escalation Study of Seneca Valley Virus (SVV-001), a Replication-Competent Picornavirus, in Relapsed/ This spending item is part of a $1,405,307 allocation. See details	National Institutes of Health	8/12/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$22,450	Trans-NIH Recovery Act Research Support The funds will be used to develop, open and analyze three H1N1 studies in HIV-infected populations. The first study will determine the safety and immunogenicity of an H1N1 vaccine in HIV-infected pregnant women. The second study will determine safety an This spending item is part of a $1,701,287 allocation. See details	National Institutes of Health	11/25/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$22,109	Trans-NIH Recovery Act Research Support The control of gene expression is at the core of biological development and homeostasis. In recent years, an unexpected form of gene regulation has been discovered in which small RNA molecules known as microRNAs (miRNAs) repress the expression of target g See details	National Institutes of Health	8/04/2009
HEALTH FEDERATION OF PHILADELPHIA, THE	$21,976	ARRA - Prevention and Wellness--Communities Putting Prevention to Work This past quarter, Philadelphia's CPPW enhanced evaluation team completed follow-up data collection on: 1) corner store environmental assessments in 200 stores, 2) food purchases of 4,000 corner store customers, 3) school environmnmental assessments in 100 ... Show more This spending item is part of a $1,747,143 allocation. See details	Centers for Disease Control and Prevention	9/30/2010
NATIONAL BLACK LEADERSHIP INITIATIVE ON CANCER, GREATER PHILADELPHIA CHAPTER, INC.	$21,529	Recovery Act Comparative Effectiveness Research - AHRQ Dissemination is an important, but neglected component of the research process. Currently, efforts focus on disseminating interventions that have been developed and evaluated through randomized trials; however, mechanisms are also needed to disseseminate th... Show more This spending item is part of a $1,414,898 allocation. See details	Agency for Healthcare Research and Quality	8/26/2010
THE INSTITUTE FOR CANCER RESEARCH	$21,331	Trans-NIH Recovery Act Research Support Title: The Porphobilinogen Synthase Family Abstract: Porphobilinogen synthase (PBGS; E.C. 4.2.1.24, a.k.a. 5-aminolevulinic acid dehydratase or ALAD) catalyzes the formation of the fundamental biological monopyrrole, porphobilinogen in the pathway toward See details	National Institutes of Health	5/21/2010
THE INSTITUTE FOR CANCER RESEARCH	$21,331	Trans-NIH Recovery Act Research Support Title: Orthropoxvirus Pathogenesis and Vaccines Abstract: Funds are requested to support the work of two undergraduate students during the summer. One of the students will help in experiments to determine the role of cytotoxic T cells in resistance to e See details	National Institutes of Health	5/24/2010
THE CHILDREN'S HOSPITAL OF PHILADELPHIA	$20,661	Trans-NIH Recovery Act Research Support DESCRIPTION This innovative proposal focuses on the fundamental question of T-cell receptor (TCR) signal initiation by peptide-MHC ligands (pMHCs). A unique feature of TCR triggering is that while soluble pMHC is incapable of triggering in solution even See details	National Institutes of Health	6/04/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$20,661	Trans-NIH Recovery Act Research Support Heparin-induced thrombocytopenia (HIT) is an iatrogenic cause of thrombocytopenia and thrombosis due to antibodies to complexes between Platelet Factor 4 (PF4) and heparin. Around half of heparinized patients develop such antibodies after cardiopulmonary See details	National Institutes of Health	6/08/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$20,080	Trans-NIH Recovery Act Research Support Patients with active ulcerative colitis (UC) despite of a therapy with 5-aminosalicylates and steroids represent a clinical challenge, since the alternatives in medical therapy are considerably fewer compared to those for patients with active Crohn's dise This spending item is part of a $388,089 allocation. See details	National Institutes of Health	9/24/2009
Philadelphia Chinatown Development Corp	$20,000	ARRA Strengthening Communities Fund ARRA Strengthening Communities Fund Nonprofits Capacity Building Program The goal of this program is to build the capacity of our nonprofit partners in order to address the broad economic recovery issues present our community, including helping low-inco This spending item is part of a $1,000,000 allocation. See details	Administration for Children and Families	9/14/2009
Institute For Safe Families	$20,000	Trans-NIH Recovery Act Research Support This application addresses Broad Challenge Area (09): Health Disparities and the Specific Challenge Topic, 09 MD 103: Initiating Innovative Interventions to Prevent Family Violence. We are engaged in the large scale demonstration project evaluating the This spending item is part of a $999,990 allocation. See details	National Institutes of Health	9/24/2009
THE CHILDREN'S HOSPITAL OF PHILADELPHIA	$18,387	Trans-NIH Recovery Act Research Support Dendritic cells (DCs) are potent antigen presenting cells (APCs) due to the ability to stimulate nai've T cells with antigen. DCs are also a promising new source of vaccine development. Endocytosis and migration are two key processes in the ability of DCs See details	National Institutes of Health	7/17/2009
HOLY FAMILY UNIVERSITY	$18,350	ARRA - Nurse Faculty Loan Program Nursing Faculty Loan Program See details	Health Resources and Services Administration	6/14/2010
WISTAR INSTITUTE OF ANATOMY & BIOLOGY (INC)	$16,825	Trans-NIH Recovery Act Research Support The intent of the Wistar/Penn SPORE in Skin Cancer is to decrease the morbidity and mortality of skin cancers through improved understanding of the pathogenesis of these diseases using novel, validated molecular biomarkers of risk, progression and prognos This spending item is part of a $175,825 allocation. See details	National Institutes of Health	9/01/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$15,900	Trans-NIH Recovery Act Research Support Title: Characterization of Type-2 Cytokine-Producing NK Cells Abstract: Allergic immune responses are biased toward the production of type-2 cytokines. We have identified new surface markers of a small subset of human natural killer (NK) cells that prod This spending item is part of a $503,770 allocation. See details	National Institutes of Health	6/04/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$15,690	Trans-NIH Recovery Act Research Support The funds will be used to develop, open and analyze three H1N1 studies in HIV-infected populations. The first study will determine the safety and immunogenicity of an H1N1 vaccine in HIV-infected pregnant women. The second study will determine safety an This spending item is part of a $1,701,287 allocation. See details	National Institutes of Health	11/25/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$14,926	Trans-NIH Recovery Act Research Support Cornelia de Lange syndrome (CdLS) is an autosomal dominant disorder of multiple congenital anomalies including characteristic facial features, upper extremity reduction defects, gastroesophageal dysfunction, growth retardation, and neurodevelopmental dela See details	National Institutes of Health	4/09/2010
THE INSTITUTE FOR CANCER RESEARCH	$10,665	Trans-NIH Recovery Act Research Support Abstract: A major goal of the parent award was to understand the mechanism of replication of hepatitis delta virus (HDV). In most of the ways in which we study the replication of the small circular RNA of HDV, we are actually detecting the accumulation o See details	National Institutes of Health	8/11/2009
THE INSTITUTE FOR CANCER RESEARCH	$10,665	Trans-NIH Recovery Act Research Support Title: Role of RPL22 in Thymocyte Development Abstract: We are asking for supplemental funds to accelerate the pace of discovery in our project seeking to understand the basis for the ?? T lineage-specific requirement for the ribosomal protein, Rpl22. Ri See details	National Institutes of Health	5/24/2010
THE INSTITUTE FOR CANCER RESEARCH	$10,665	Trans-NIH Recovery Act Research Support Title: Structure and Function of Integrase Abstract: The proposed summer project is related to Aim 3 of the parent grant, entitled ?Structure and Function of Integrase?. The goal of this Specific Aim is to prepare stable complexes containing integrase (I See details	National Institutes of Health	5/24/2010
THE INSTITUTE FOR CANCER RESEARCH	$10,665	Trans-NIH Recovery Act Research Support Title: Low Activity Oligomers of Porphobilinogen Synthase as Antibiotic Targets Abstract: Porphobilinogen synthase (PBGS) catalyzes the essential formation of the fundamental biological monopyrrole, porphobilinogen in the pathway toward the biosynthesis See details	National Institutes of Health	6/01/2010
THE INSTITUTE FOR CANCER RESEARCH	$10,665	Trans-NIH Recovery Act Research Support Title: MHC Class I Antigen Presentation in Viral Infections Abstract: Funds are requested to support the work of one undergraduate student during the summer. The work of the student will be to screen for and characterize monoclonal antibodies that recog See details	National Institutes of Health	5/24/2010
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$9,234	Trans-NIH Recovery Act Research Support DESCRIPTION (provided by applicant): There have been many efforts to assess the intensity, frequency and duration of PA among males and females and people of all ages, but few efforts to objectively assess population level measures of PA. Determining popu This spending item is part of a $29,907 allocation. See details	National Institutes of Health	5/29/2009
FOX CHASE CANCER CENTER	$9,180	Trans-NIH Recovery Act Research Support As the second largest employer in Northeast Philadelphia, Fox Chase Cancer Center (FCCC) provides a substantial economic impact locally that extends beyond the immediate area to provide economic benefits regionally, throughout the Pennsylvania, Delaware a See details	National Institutes of Health	6/01/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$8,111	Trans-NIH Recovery Act Research Support Our studies address a critical problem in hemoglobin (Hb) biology: how inherently unstable globin protein subunits are folded and maintained during normal and pathological erythropoiesis. We discovered alpha hemoglobin stabilizing protein (AHSP), an eryth See details	National Institutes of Health	7/13/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$7,500	Trans-NIH Recovery Act Research Support The proposed project will promote expanded and improved community engagement (CE) by academic medical centers (AMCs) through two related activities: 1) collaboratively rewriting the CDC's seminal 'Principles of Community Engagement' (PCE), and 2) implemen This spending item is part of a $598,935 allocation. See details	National Institutes of Health	8/13/2009
THE CHILDREN'S HOSPITAL OF PHILADELPHIA	$6,400	Trans-NIH Recovery Act Research Support Inadequate cell mass is common to both type 1 and type 2 diabetes. Our long-term research goal is to understand the signals that influence -cell growth, as a step towards regeneration of -cell mass in diabetes patients. Surprisingly little is known about See details	National Institutes of Health	2/01/2010
PENN DETROIT DIESEL ALLISON LLC	$5,000	ARRA - Preventing Healthcare-Associated Infections This program is intended to address the Health and Human Services Action Plan to prevent healthcare associated infections (HAI). Funding will provide for technical assistance to make critical short-term investments that will provide for a sustainablble sta... Show more This spending item is part of a $1,020,480 allocation. See details	Centers for Disease Control and Prevention	8/28/2009
Thomas Jefferson University	$5,000	ARRA - Preventing Healthcare-Associated Infections This program is intended to address the Health and Human Services Action Plan to prevent healthcare associated infections (HAI). Funding will provide for technical assistance to make critical short-term investments that will provide for a sustainablble sta... Show more This spending item is part of a $1,020,480 allocation. See details	Centers for Disease Control and Prevention	8/28/2009
PENNSYLVANIA HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA HEALTH SYSTEM	$5,000	ARRA - Preventing Healthcare-Associated Infections This program is intended to address the Health and Human Services Action Plan to prevent healthcare associated infections (HAI). Funding will provide for technical assistance to make critical short-term investments that will provide for a sustainablble sta... Show more This spending item is part of a $1,020,480 allocation. See details	Centers for Disease Control and Prevention	8/28/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$4,000	Trans-NIH Recovery Act Research Support This is a translational research proposal to elucidate the mechanisms underlying apparent differences in end-organ iron deposition between patients with sickle cell anemia (SCD), thalassemia (TM) and Diamond Blackfan Anemia (DBA). Increasing numbers of This spending item is part of a $645,010 allocation. See details	National Institutes of Health	9/10/2009
CHILDRENS HOSPITAL OF PHILADELPHIA	$2,928	Trans-NIH Recovery Act Research Support The funds will be used to develop, open and analyze three H1N1 studies in HIV-infected populations. The first study will determine the safety and immunogenicity of an H1N1 vaccine in HIV-infected pregnant women. The second study will determine safety an This spending item is part of a $1,701,287 allocation. See details	National Institutes of Health	11/25/2009
Jeanes Hospital	$2,500	ARRA - Preventing Healthcare-Associated Infections This program is intended to address the Health and Human Services Action Plan to prevent healthcare associated infections (HAI). Funding will provide for technical assistance to make critical short-term investments that will provide for a sustainablble sta... Show more This spending item is part of a $1,020,480 allocation. See details	Centers for Disease Control and Prevention	8/28/2009
Chhs Hospital Company LLC	$2,500	ARRA - Preventing Healthcare-Associated Infections This program is intended to address the Health and Human Services Action Plan to prevent healthcare associated infections (HAI). Funding will provide for technical assistance to make critical short-term investments that will provide for a sustainablble sta... Show more This spending item is part of a $1,020,480 allocation. See details	Centers for Disease Control and Prevention	8/28/2009
Nazareth Hospital	$2,346	ARRA - Preventing Healthcare-Associated Infections This program is intended to address the Health and Human Services Action Plan to prevent healthcare associated infections (HAI). Funding will provide for technical assistance to make critical short-term investments that will provide for a sustainablble sta... Show more This spending item is part of a $1,020,480 allocation. See details	Centers for Disease Control and Prevention	8/28/2009
FOX CHASE CANCER CENTER	$2,275	Trans-NIH Recovery Act Research Support It has been suggested that the small fraction of tumor cells capable of initiating local or distant recurrence exhibit properties of stem cells, and that identification and molecular characterization of putative cancer stem cells will lead to better outco This spending item is part of a $535,374 allocation. See details	National Institutes of Health	9/15/2009
PHILADELPHIA, CITY OF	$1,000	ARRA - Immunization The prevention and control of vaccine preventable diseases is a major priority for the Philadelphia Department of Public Health (PDPH). Invasive meningococcal disease, pertussis, and invasive Haemophilus influenzae serotype b infections (Hib) are three c This spending item is part of a $125,288 allocation. See details	Centers for Disease Control and Prevention	9/03/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$0	Trans-NIH Recovery Act Research Support These studies provide fundamental and basic insights into new pathways through which the immune system responds to organ and tissue transplants. The results of these studies will be useful in the design and implementation of strategies into the clinical c See details	National Institutes of Health	9/21/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$0	Trans-NIH Recovery Act Research Support The purpose of this proposal is to expand the capabilities of the Center for Experimental Neurorehabilitation Research Training (CENT) by adding a desktop scanning electron microscope (EM) capability to our micro imaging armamentarium. The laboratory of See details	National Institutes of Health	9/26/2009
PHILADELPHIA, CITY OF	$0	ARRA - Immunization The Philadelphia Department of Public Health (PDPH) in collaboration with the Centers for Disease Control and Prevention (CDC) will conduct a matched, case-control study to examine the incremental effectiveness of the 2-dose varicella vaccination regimen This spending item is part of a $150,000 allocation. See details	Centers for Disease Control and Prevention	9/15/2009
PHILADELPHIA, CITY OF	$0	ARRA Strengthening Communities Fund ARRA Strengthening Communities Fund State, Local, and Tribal Government Capacity Building Program This award is made to State, city, county, and Indian/Native American Tribal governments (or organizations designated by such governments) in order to build This spending item is part of a $249,333 allocation. See details	Administration for Children and Families	9/23/2009
GYNECOLOGIC ONCOLOGY GROUP , THE	$0	Trans-NIH Recovery Act Research Support The Gynecologic Oncology Group (GOG) is the premier clinical trial research program investigating new therapeutic approaches in the management of gynecologic malignancies. This multidisciplinary, multimodal Group comprises over 200 participating universit This spending item is part of a $543,182 allocation. See details	National Institutes of Health	8/31/2009
WISTAR INSTITUTE OF ANATOMY & BIOLOGY (INC)	$0	Trans-NIH Recovery Act Research Support The overall goal of this application is to define the factors that shape antiviral T and B cell immunity and delineate the mechanisms by which these factors operate. We have focused on three factors that could shape effector and memory lymphocyte differen This spending item is part of a $161,177 allocation. See details	National Institutes of Health	9/21/2009
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	$0	Trans-NIH Recovery Act Research Support Project Title: A Six-Month, RCT of Probuphine Safety and Efficacy in Opioid Addiction. We are conducting a six-month, randomized, placebo and active-controlled, multicenter clinical trial of Probuphine in patients with opioid dependence for the purpose This spending item is part of a $7,586,848 allocation. See details	National Institutes of Health	9/30/2009

Recovery Tracker

Philadelphia County, Pa., funds by Health and Human Services, Department of